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Transitional b cell infection

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https://www.readbyqxmd.com/read/28072956/-clinical-and-immunological-analysis-of-the-patient-with-autoimmunity-due-to-germline-stat3-gain-of-function-mutation
#1
Y Ding, Y Zhang, Y P Wang, H Y Zhao, X M Chen, X H Xue, X M Bai, Y F An, Z Y Zhang, X M Tang, X D Zhao
Objective: To investigate the clinical and immunological laboratory features and gene mutation in a female patient who carried a germline gain-of-function mutation in STAT3. Method: A patient with lymphadenopathy and pancytopenia, visited the Department of Rheumatology and Immunology of Children's Hospital of Chongqing Medical University in May 2016. The clinical and laboratory characteristics, results of immunophenotyping and exome sequencing were analyzed retrospectively and related literature was reviewed...
January 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28072954/-clinical-and-immunological-analysis-of-patients-with-activated-phosphoinositide-3-kinase-%C3%AE-syndrome-resulting-from-pik3cd-mutation
#2
W J Tang, W Wang, Y Luo, Y P Wang, L Li, Y F An, L J Gou, M S Ma, T Y He, J Yang, X D Zhao, H M Song
Objective: To explore the clinical and immunological features, gene mutations, treatment and prognosis in patients with activated phosphoinositide 3-kinase δ syndrome (APDS) caused by PIK3CD gene heterozygous germline mutation. Method: The data of clinical, immunological phenotype, treatment, and prognosis of 15 patients with APDS, who visited Children's Hospital of Chongqing Medical University, Peking Union Medical College Hospital, and Shenzhen Children's Hospital from June 2014 to November 2016, were collected and analyzed...
January 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28039305/effect-of-antiretroviral-therapy-on-the-memory-and-activation-profiles-of-b-cells-in-hiv-infected-african-women
#3
Ramla F Tanko, Andreia P Soares, Tracey L Müller, Nigel J Garrett, Natasha Samsunder, Quarraisha Abdool Karim, Salim S Abdool Karim, Catherine Riou, Wendy A Burgers
Human immunodeficiency virus infection induces a wide range of effects in B cells, including skewed memory cell differentiation, compromised B cell function, and hypergammaglobulinemia. However, data on the extent to which these B cell abnormalities can be reversed by antiretroviral therapy (ART) are limited. To investigate the effect of ART on B cells, the activation (CD86) and differentiation (IgD, CD27, and CD38) profiles of B cells were measured longitudinally in 19 HIV-infected individuals before (median, 2 mo) and after ART initiation (median, 12 mo) and compared with 19 age-matched HIV-uninfected individuals using flow cytometry...
December 30, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28036372/collapse-of-cytolytic-potential-in-siv-specific-cd8-t-cells-following-acute-siv-infection-in-rhesus-macaques
#4
Emily R Roberts, Diane G Carnathan, Hui Li, George M Shaw, Guido Silvestri, Michael R Betts
Poor maintenance of cytotoxic factor expression among HIV-specific CD8+ T cells, in part caused by dysregulated expression of the transcription factor T-bet, is associated with HIV disease progression. However, the precise evolution and context in which CD8+ T cell cytotoxic functions become dysregulated in HIV infection remain unclear. Using the rhesus macaque (RM) SIV infection model, we evaluated the kinetics of SIV-specific CD8+ T cell cytolytic factor expression in peripheral blood, lymph node, spleen, and gut mucosa from early acute infection through chronic infection...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/28031365/acmnpv-ac83-is-a-pif-protein-required-for-odv-and-bv-nucleocapsid-assembly-as-well-as-assembly-of-the-pif-complex-in-odv-envelopes
#5
Muhammad Afzal Javed, Siddhartha Biswas, Leslie G Willis, Stephanie Harris, Caitlin Pritchard, Monique M van Oers, B Cameron Donly, Martin A Erlandson, Dwayne D Hegedus, David A Theilmann
: Baculovirus occlusion derived virus (ODV) initiate infection of lepidopteran larval hosts by binding to the midgut epithelia which is mediated by per os infectivity factors (PIFs). Autographa californica multiple nucleopolyhedrovirus (AcMNPV) encodes seven PIF proteins of which PIF1-4 form a core complex in ODV envelopes to which PIF0 and PIF6 loosely associate. Deletion of any pif results in ODV unable to bind or enter midgut cells. AC83 also associates with the PIF complex and this study further analyzed its role in oral infectivity to determine if it is a PIF protein...
December 28, 2016: Journal of Virology
https://www.readbyqxmd.com/read/28003338/a-predicted-cation-transporter-protein-bpss1228-is-involved-in-intracellular-behaviour-of-burkholderia-pseudomallei-in-a-human-lung-epithelial-cell-line-a549
#6
Teerasit Techawiwattanaboon, Sorujsiri Chareonsudjai
Burkholderia pseudomallei causes melioidosis, a potentially fatal infectious disease in tropical and subtropical countries worldwide. The intracellular behaviour of this pathogen in host cells has been reported to impact the severity of melioidosis, including the development of septicaemia, a consequence of pneumonia melioidosis. We previously identified a predicted cation transporter protein, BPSS1228, that participates in the transitional stage of this intracellular pathogen. For further analysis, in this study B...
December 2016: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/27980783/plasmodium-chabaudi-infection-induces-aid-expression-in-transitional-and-marginal-zone-b-cells
#7
Joel R Wilmore, Alexander C Maue, Rosemary Rochford
INTRODUCTION: Endemic Burkitt's lymphoma (eBL) is associated with Epstein-Barr virus and repeated malaria infections. A defining feature of eBL is the translocation of the c-myc oncogene to the control of the immunoglobulin promoter. Activation-induced cytidine deaminase (AID) has been shown to be critical for this translocation. Malaria infection induces AID in germinal center B cells, but whether malaria infection more broadly affects AID activation in extrafollicular B cells is unknown...
December 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27980777/improved-b-cell-development-in-humanized-nod-scid-il2r%C3%AE-null-mice-transgenically-expressing-human-stem-cell-factor-granulocyte-macrophage-colony-stimulating-factor-and-interleukin-3
#8
Sonal Jangalwe, Leonard D Shultz, Anuja Mathew, Michael A Brehm
INTRODUCTION: Immunodeficient mice engrafted with human immune systems support studies of human hematopoiesis and the immune response to human-specific pathogens. A significant limitation of these humanized mouse models is, however, a severely restricted ability of human B cells to undergo class switching and produce antigen-specific IgG after infection or immunization. METHODS: In this study, we have characterized the development and function of human B cells in NOD-scid IL2Rγ(null) (NSG) mice transgenically expressing human stem cell factor (SCF), granulocyte macrophage colony-stimulating factor (GM-CSF), and IL-3 (NSG-SGM3) following engraftment with human hematopoietic stem cells, autologous fetal liver, and thymic tissues (bone marrow, liver, thymus or BLT model)...
December 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27965258/a-new-autoinflammatory-and-autoimmune-syndrome-associated-with-nlrp1-mutations-naiad-nlrp1-associated-autoinflammation-with-arthritis-and-dyskeratosis
#9
Sylvie Grandemange, Elodie Sanchez, Pascale Louis-Plence, Frédéric Tran Mau-Them, Didier Bessis, Christine Coubes, Eric Frouin, Marieke Seyger, Manon Girard, Jacques Puechberty, Valérie Costes, Michel Rodière, Aurélia Carbasse, Eric Jeziorski, Pierre Portales, Guillaume Sarrabay, Michel Mondain, Christian Jorgensen, Florence Apparailly, Esther Hoppenreijs, Isabelle Touitou, David Geneviève
OBJECTIVES: Inflammasomes are multiprotein complexes that sense pathogens and trigger biological mechanisms to control infection. Nucleotide-binding oligomerisation domain-like receptor (NLR) containing a PYRIN domain 1 (NLRP1), NLRP3 and NLRC4 plays a key role in this innate immune system by directly assembling in inflammasomes and regulating inflammation. Mutations in NLRP3 and NLRC4 are linked to hereditary autoinflammatory diseases, whereas polymorphisms in NLRP1 are associated with autoimmune disorders such as vitiligo and rheumatoid arthritis...
December 13, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27881650/mechanism-of-enhanced-hiv-restriction-by-virion-coencapsidated-cytidine-deaminases-apobec3f-and-apobec3g
#10
Anjuman Ara, Robin P Love, Tyson B Follack, Khawaja A Ahmed, Madison B Adolph, Linda Chelico
: The APOBEC3 (A3) enzymes, A3G and A3F, are coordinately expressed in CD4+ T cells and can become coencapsidated into HIV-1 virions, primarily in the absence of the viral infectivity factor (Vif). A3F and A3G are deoxycytidine deaminases that inhibit HIV-1 replication by inducing guanine to adenine hypermutation through deamination of cytosine to form uracil in (-)DNA. The effect of the simultaneous presence of both A3G and A3F on HIV-1 restriction ability is not clear. Here, we used a single cycle infectivity assay and biochemical analyses to determine if coencapsidated A3G and A3F differ in their restriction capacity than A3G or A3F alone...
November 23, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27834949/direct-interaction-of-human-serum-proteins-with-aav-virions-to-enhance-aav-transduction-immediate-impact-on-clinical-applications
#11
M Wang, J Sun, A Crosby, K Woodard, M L Hirsch, R J Samulski, C Li
Recent hemophilia B clinical trials using adeno-associated virus (AAV) gene delivery have demonstrated much lower coagulation factor IX (FIX) production in patients compared with the high levels observed in animal models and AAV capsid-specific cytotoxic T lymphocyte response elicited at high doses of AAV vectors. These results emphasize the necessity to explore effective approaches for enhancement of AAV transduction. Initially, we found that incubation of all AAV vectors with human serum enhanced AAV transduction...
December 1, 2016: Gene Therapy
https://www.readbyqxmd.com/read/27795397/release-of-gp120-restraints-leads-to-an-entry-competent-intermediate-state-of-the-hiv-1-envelope-glycoproteins
#12
Alon Herschhorn, Xiaochu Ma, Christopher Gu, John D Ventura, Luis Castillo-Menendez, Bruno Melillo, Daniel S Terry, Amos B Smith, Scott C Blanchard, James B Munro, Walther Mothes, Andrés Finzi, Joseph Sodroski
: Primary human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimers [(gp120/gp41)3] typically exist in a metastable closed conformation (state 1). Binding the CD4 receptor triggers Env to undergo extensive conformational changes to mediate virus entry. We identified specific gp120 residues that restrain Env in state 1. Alteration of these restraining residues destabilized state 1, allowing Env to populate a functional conformation (state 2) intermediate between state 1 and the full CD4-bound state (state 3)...
October 25, 2016: MBio
https://www.readbyqxmd.com/read/27792773/rna-seq-transcriptomic-responses-of-full-thickness-dermal-excision-wounds-to-pseudomonas-aeruginosa-acute-and-biofilm-infection
#13
S L Rajasekhar Karna, Peter D'Arpa, Tsute Chen, Li-Wu Qian, Andrea B Fourcaudot, Kazuyoshi Yamane, Ping Chen, Johnathan J Abercrombie, Tao You, Kai P Leung
Pseudomonas aeruginosa infections of wounds in clinical settings are major complications whose outcomes are influenced by host responses that are not completely understood. Herein we evaluated transcriptomic changes of wounds as they counter P. aeruginosa infection-first active infection, and then chronic biofilm infection. We used the dermal full-thickness, rabbit ear excisional wound model. We studied the wound response: towards acute infection at 2, 6, and 24 hrs after inoculating 106 bacteria into day-3 wounds; and, towards more chronic biofilm infection of wounds similarly infected for 24 hrs but then treated with topical antibiotic to coerce biofilm growth and evaluated at day 5 and 9 post-infection...
2016: PloS One
https://www.readbyqxmd.com/read/27733647/in-vivo-efficacy-of-measles-virus-fusion-protein-derived-peptides-is-modulated-by-the-properties-of-self-assembly-and-membrane-residence
#14
T N Figueira, L M Palermo, A S Veiga, D Huey, C A Alabi, N C Santos, J C Welsch, C Mathieu, B Horvat, S Niewiesk, A Moscona, M A R B Castanho, M Porotto
: Measles virus (MV) infection is undergoing resurgence and remains one of the leading causes of death among young children worldwide despite the availability of an effective measles vaccine. MV infects its target cells by coordinated action of the MV hemagglutinin (H) and fusion (F) envelope glycoproteins; upon receptor engagement by H, the prefusion F undergoes a structural transition, extending and inserting into the target cell membrane and then refolding into a postfusion structure that fuses the viral and cell membranes...
January 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/27717724/comparison-of-various-classifications-for-patients-with-common-variable-immunodeficiency-cvid-using-measurement-of-b-cell-subsets
#15
R Yazdani, R Seify, M Ganjalikhani-Hakemi, H Abolhassani, N Eskandari, F Golsaz-Shirazi, B Ansaripour, E Salehi, G Azizi, N Rezaei, A Aghamohammadi
BACKGROUND: Common variable immunodeficiency (CVID) is a heterogeneous disease, characterised by hypogammaglobulinaemia leading to recurrent infections and various complications. The aim of this study was to classify CVID patients based on four known classifications (Paris, Freiburg, EUROclass, and B-cell patterns) by measurement of B-cell subsets and to assess the relation of each classification with clinical manifestations. METHODS: We measured all B-cell subsets as both absolute count and percentage in 30 CVID patients and 30 healthy individuals using four-colour flow cytometry...
October 4, 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27688750/nutrition-and-helicobacter-pylori-host-diet-and-nutritional-immunity-influence-bacterial-virulence-and-disease-outcome
#16
REVIEW
Kathryn P Haley, Jennifer A Gaddy
Helicobacter pylori colonizes the stomachs of greater than 50% of the world's human population making it arguably one of the most successful bacterial pathogens. Chronic H. pylori colonization results in gastritis in nearly all patients; however in a subset of people, persistent infection with H. pylori is associated with an increased risk for more severe disease outcomes including B-cell lymphoma of mucosal-associated lymphoid tissue (MALT lymphoma) and invasive adenocarcinoma. Research aimed at elucidating determinants that mediate disease progression has revealed genetic differences in both humans and H...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27552680/bone-marrow-b-lymphocytes-in-multiple-myeloma-and-mgus-focus-on-distribution-of-na%C3%A3-ve-cells-and-memory-subsets
#17
Fanny Pojero, Alessandra Casuccio, Caterina Giambanco, Matteo Bulati, Silvio Buffa, Francesco Di Bassiano, Francesco Gervasi, Calogero Caruso, Giuseppina Colonna Romano
BACKGROUND/AIMS: Multiple myeloma (MM) is caused by proliferation of clonal plasma cells (cPCs) in bone marrow (BM), associated with numerical and functional defects in immune subsets. An impairment of B cell compartment is involved in onset/progression of the disease. METHODS: By flow cytometry, we studied distribution of naïve/transitional (IgD(+)CD27(-)), memory unswitched (IgD(+)CD27(+)), memory switched (IgD(-)CD27(+)) and double negative (DN) (IgD(-)CD27(-)) B lymphocytes in BM of control subjects, and responding and relapsing patients...
October 2016: Leukemia Research
https://www.readbyqxmd.com/read/27508045/effect-of-hepatitis-b-virus-infection-on-trophoblast-cell-line-htr-8-svneo-and-choriocarcinoma-cell-line-jeg3-is-linked-to-cd133-2-ac141-expression
#18
Hong Cui, Jing Chen, Quan Na
Mother-to-infant transmission of hepatitis B virus (HBV) plays an important role in the chronic carrier state in China. In our studies, the response of trophoblast cell and choriocarcinoma cell to HBV infection regarding the expression of CD133-2 (AC141) was evaluated. Western blot and RT-PCR showed that a high level of CD133-2 protein and mRNA in HTR-8/SVneo cells, but a low level in JEG-3 cells. Lower proliferation and mobility, and higher apoptosis were observed in HTR-8/SVneo cells and JEG-3-CD133-2(+) cells after HBV infection than those in HTR-8-CD133-2(-) cells and JEG-3 cells...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27507825/localization-of-the-houdinisome-ejection-proteins-inside-the-bacteriophage-p22-virion-by-bubblegram-imaging
#19
Weimin Wu, Justin C Leavitt, Naiqian Cheng, Eddie B Gilcrease, Tina Motwani, Carolyn M Teschke, Sherwood R Casjens, Alasdair C Steven
UNLABELLED: The P22 capsid is a T=7 icosahedrally symmetric protein shell with a portal protein dodecamer at one 5-fold vertex. Extending outwards from that vertex is a short tail, and putatively extending inwards is a 15-nm-long α-helical barrel formed by the C-terminal domains of portal protein subunits. In addition to the densely packed genome, the capsid contains three "ejection proteins" (E-proteins [gp7, gp16, and gp20]) destined to exit from the tightly sealed capsid during the process of DNA delivery into target cells...
2016: MBio
https://www.readbyqxmd.com/read/27463802/kshv-mediated-regulation-of-par3-and-snail-contributes-to-b-cell-proliferation
#20
Hem C Jha, Zhiguo Sun, Santosh K Upadhyay, Darine W El-Naccache, Rajnish K Singh, Sushil K Sahu, Erle S Robertson
Studies have suggested that Epithelial-Mesenchymal Transition (EMT) and transformation is an important step in progression to cancer. Par3 (partitioning-defective protein) is a crucial factor in regulating epithelial cell polarity. However, the mechanism by which the latency associated nuclear antigen (LANA) encoded by Kaposi's Sarcoma associated herpesvirus (KSHV) regulates Par3 and EMTs markers (Epithelial-Mesenchymal Transition) during viral-mediated B-cell oncogenesis has not been fully explored. Moreover, several studies have demonstrated a crucial role for EMT markers during B-cell malignancies...
July 2016: PLoS Pathogens
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