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Evodiamine

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https://www.readbyqxmd.com/read/28219365/exploration-of-anti-cancer-effects-and-mechanisms-of-zuo-jin-wan-and-its-alkaloid-components-in-vitro-and-in-orthotopic-hepg2-xenograft-immunocompetent-mice
#1
Shun-Ting Chou, Chien-Yun Hsiang, Hsin-Yi Lo, Hui-Fen Huang, Ming-Tsung Lai, Ching-Liang Hsieh, Su-Yin Chiang, Tin-Yun Ho
BACKGROUND: Zuo-Jin-Wan (ZJW), a two-herb formula consisting of Coptis chinensis (CC) and Evodia rutaecarpa (ER), is commonly used in traditional Chinese medicine for the treatment of cancers. However, the efficacies and mechanisms of ZJW and its alkaloid components on cancers are still unclear. METHODS: Here we investigated the anti-cancer effects and mechanisms of ZJW, CC, ER, berberine, and evodiamine in cells and in intrahepatic xenograft mice. RESULTS: Treatment of HepG2 cells with ZJW, CC, ER, berberine, and evodiamine significantly displayed cytotoxic effects in a dose- and time-dependent manner...
February 20, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28190539/corrigendum-to-evodiamine-a-plant-alkaloid-induces-calcium-jnk-mediated-autophagy-and-calcium-mitochondria-mediated-apoptosis-in-human-glioblastoma-cells-chem-biol-interact-205-1-2013-sep-5-20-28
#2
Ann-Jeng Liu, Sheng-Hao Wang, Ku-Chung Chen, Hsiu-Ping Kuei, Yung-Luen Shih, Sz-Ying Hou, Wen-Ta Chiu, Sheng-Huang Hsiao, Chwen-Ming Shih
No abstract text is available yet for this article.
February 9, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28154330/analgesic-effects-and-side-effects-of-ephedra-herb-extract-and-ephedrine-alkaloids-free-ephedra-herb-extract
#3
Yoshinori Kobayashi
 Ephedra Herb is classified "pungent, slightly bitter, and warm" in tastes and natures, and is used to provide warmth to the body, dispel coldness, remove dampness, and reduce pain. Similar herbs are "pungent and hot" chili peppers, "pungent and hot" evodia fruit," "pungent and warm" ginger, "pungent and hot" processed ginger, "pungent and hot" Zanthoxylum fruit, etc. These herbs are prescribed to provide heat to the outer or inner body. Some pungent components such as capsaicin, evodiamine, gingerol, and shogaol are known to be activators of transient receptor potential vanilloid 1 (TRPV1)...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28146096/pharmacokinetics-studies-of-12-alkaloids-in-rat-plasma-after-oral-administration-of-zuojin-and-fan-zuojin-formulas
#4
Ping Qian, You-Bo Zhang, Yan-Fang Yang, Wei Xu, Xiu-Wei Yang
Zuojin formula (ZJ) is a traditional Chinese medicine (TCM) prescription consisted of Coptidis Rhizoma (CR) and Euodiae Fructus (EF), and has been used to treat gastrointestinal (GI) disease for more than 700 years. Fan-Zuojin formula (FZJ) is a related TCM prescription also consisted of CR and EF with the opposite proportion. In recent years, ZJ was getting more attention for its antitumor potential, but the indeterminate pharmacokinetic (PK) behavior restricted its clinical applications, and the PK differences between ZJ and FZJ were also largely unknown...
January 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28098901/effect-of-evodiamine-and-berberine-on-the-interaction-between-dnmts-and-target-micrornas-during-malignant-transformation-of-the-colon-by-tgf-%C3%AE-1
#5
Chao Huang, Hong Liu, Xiu-Li Gong, Li-Yun Wu, Bin Wen
The tissue microenvironment functions as a crucial player in carcinogenesis, and transforming growth factor-β1 (TGF-β1) within the microenvironment stimulates the formation of neoplasms. Using an in vitro model of malignancy induced by TGF-β1, we assessed the effect of evodiamine and berberine on the interaction between DNA methyltransferases (DNMTs) and target microRNAs (miRNAs) in the model. Colon tissues from neonatal rats 7 days of age were cultured and malignancy was induced by TGF-β1 in vitro for 48 h, and then the tissues were respectively treated with evodiamine and berberine for 24 h...
January 17, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28010025/evodiamine-prevents-isoproterenol-induced-cardiac-fibrosis-by-regulating-endothelial-to-mesenchymal-transition
#6
Xiao-Han Jiang, Qing-Qing Wu, Yang Xiao, Yuan Yuan, Zheng Yang, Zhou-Yan Bian, Wei Chang, Qi-Zhu Tang
Evodiamine, a major component of Evodia rutaecarpa, can protect the myocardium against injury induced by atherosclerosis and ischemia-reperfusion. However, the effect of evodiamine against cardiac fibrosis remains unclear. This study aims to investigate the possible effect and mechanism involved in the function of evodiamine on isoproterenol-induced cardiac fibrosis and endothelial-to-mesenchymal transition. Isoproterenol was used to induce cardiac fibrosis in mice, and evodiamine was gavaged simultaneously...
December 23, 2016: Planta Medica
https://www.readbyqxmd.com/read/27878250/sn38-increases-il-8-expression-through-the-mapk-pathways-in-hct8-cells
#7
Lei Zhang, Wen-Hui Lou, Xue-Feng Xu, Wenchuan Wu, Ye-Fei Rong, Da-Yong Jin
The overexpression of interleukin-8 (IL-8) is closely associated with poor tumor differentiation, metastasis and tumor progression. This study aimed to examine the effects and mechanisms of action of SN38 (a metabolite of the camptothecin derivative, CPT-11) on IL-8 expression in HCT8 cells, using ELISA, CCK-8 and western blot analysis. Among jatrorrhizine, evodiamine, 5-fluorouracil and SN38, SN38 was found to inhibit the proliferation of HCT8 cells in a dose-dependent manner, but to increase IL-8 secretion from HCT8 cells...
January 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27848250/pharmacological-effects-of-active-components-of-chinese-herbal-medicine-in-the-treatment-of-alzheimer-s-disease-a-review
#8
REVIEW
Zhi-Yong Wang, Jian-Gang Liu, Hao Li, Hui-Ming Yang
Alzheimer's disease (AD), the most common neurodegenerative disorder associated with dementia, not only severely decreases the quality of life for its victims, but also brings a heavy economic burden to the family and society. Unfortunately, few chemical drugs designed for clinical applications have reached the expected preventive or therapeutic effect so far, and combined with their significant side-effects, there is therefore an urgent need for new strategies to be developed for AD treatment. Traditional Chinese Medicine has accumulated many experiences in the treatment of dementia during thousands of years of practice; modern pharmacological studies have confirmed the therapeutic effects of many active components derived from Chinese herbal medicines (CHM)...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27771931/evodiamine-and-its-role-in-chronic-diseases
#9
Qunyou Tan, Jingqing Zhang
Evodiamine (EVO) is a major alkaloid compound extracted from the dry unripened fruit Evodiae fructus (Evodia rutaecarpa Benth., Rutaceae). EVO has a variety of pharmacological activities, such as anti-obesity, anti-allergenic, analgesic, anti-tumor, anti-ulcerogenic, and neuroprotective activities. EVO has varying efficacies in animal models and humans. Here, the physicochemical properties of EVO are presented, and the EVO's functions and mechanisms of action in various chronic diseases are reviewed. EVO is worth exploring in more depth in the future for its potential use in various chronic diseases...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27748810/evodiamine-inhibits-pdgf%C3%A2-bb%C3%A2-induced-proliferation-of-rat-vascular-smooth-muscle-cells-through-the-suppression-of-cell-cycle-progression-and-oxidative-stress
#10
Xie Ge, Si-Yu Chen, Mei Liu, Ting-Ming Liang, Chang Liu
Vascular smooth muscle cell (VSMC) proliferation is a key event in the development of in‑stent restenosis. Evodiamine is an indole alkaloid extracted from the Chinese medicine, evodia, and has been shown to inhibit tumor cell proliferation and protect the cardiovascular system. However, whether evodiamine affects VSMC proliferation remains to be elucidated. Therefore, the present study examined the effects and the mechanisms of action of evodiamine on the proliferation of rat VSMCs. The cells were treated with evodiamine alone or in combination with platelet‑derived growth factor‑BB (PDGF‑BB) stimulation...
November 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27498361/anti-endotoxin-and-anti-inflammatory-effects-of-chinese-herbal-medicinal-alkaloid-ingredients-in%C3%A2-vivo
#11
Yiyi Hu, Aihua Mao, Zhengyu Yu, Kongwang He
The aim of the research was to investigate the anti-endotoxin and anti-inflammatory effects of sinomenine, fangchinoline, stachydrine, chuanxionggzine, oxymartrine, and evodiamine alkaloids commonly found in Chinese herbal medicines. In an endotoxin (LPS) control group, each mouse was challenged with 1 mg LPS/kg by intraperitoneal (IP) injection. In high-, middle- and low-dose alkaloid groups, mice were initially challenged with 1 mg LPS/kg by IP injection and, 3 h later, dosed intramuscularly (IM) with one of the six alkaloids at one of three levels (1, 5, or 10 mg/kg body weight)...
October 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27485202/effect-of-evodiamine-on-the-proliferation-and-apoptosis-of-a549-human-lung-cancer-cells
#12
Li Lin, Li Ren, Liujing Wen, Yu Wang, Jin Qi
Evodia rutaecarpa is a plant, which has antitumor activity. Evodiamine is an alkaloid with antitumor activity present in E. rutaecarpa and has potential to be developed into a therapeutic antitumor agent. The present study investigated the effect of evodiamine on the proliferation of A549 human lung cancer cells and the mechanism underlying these effects. The results indicated that evodiamine significantly inhibited proliferation, induced apoptosis and the expression of reactive oxygen species, arrested the cell cycle, regulated the expression of Survivin, Bcl-2 and Cyclin B1, regulated the activity of caspase-3/8 and glutathione in tumor cells, and decreased the activity of AKT/nuclear factor‑κB (NF‑κB) and Sonic hedgehog/GLI family zinc finger 1 (SHH/GLI1) signaling pathways in A549 cells...
September 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27468551/-evodiamine-induces-extrinsic-and-intrinsic-apoptosis-of-ovarian-cancer-cells-via-the-mitogen-activated-protein-kinase-phosphatidylinositol-3-kinase-protein-kinase-b-signaling-pathways
#13
Lijuan Wei, Xiaoying Jin, Zipei Cao, Wenlu Li
OBJECTIVE: To explore the effects of evodiamine on ovarian cancer cells and the mechanisms underlying such effects. METHODS: Human. ovarian cancer cells HO-8910PM were treated with evodiamine at 0, 1.25, 2.5, and 5 μM for 1-4 d. 3-(4,5-Dimethiylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to detect the growth inhibition rate of evodiamine-treated HO-8910PM cells. The cell cycle was observed via propidium iodide (PI) staining. Apoptosis induction was assessed via Annexin V-fluorescein isothiocyanate/propidium iodide (Annexin V-FITC/PI) double staining assay...
June 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
https://www.readbyqxmd.com/read/27462166/effect-of-evodiamine-and-berberine-on-mir-429-as-an-oncogene-in-human-colorectal-cancer
#14
Hong Liu, Chao Huang, Liyun Wu, Bin Wen
Loss of epithelial organization and deregulated microRNAs are hallmarks of malignant carcinomas, but the relationship between them has been poorly understood. This study was designed to investigate the changes in the expression of E-cadherin, Par3, and miR-429 during the development of human colorectal cancer (CRC). E-cadherin and Par3 levels were quantitatively detected by immunohistochemistry and Western blotting. An in vitro culture of colorectal tissue was established to analyze the effect of berberine (BER) and evodiamine (EVO) on the level of miR-429...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27458481/a-promising-antitumor-activity-of-evodiamine-incorporated-in-hydroxypropyl-%C3%AE-cyclodextrin-pro-apoptotic-activity-in-human-hepatoma-hepg2-cells
#15
Chao Qiu, Li-Na Gao, Kuo Yan, Yuan-Lu Cui, Ye Zhang
BACKGROUND: Evodiamine has gained wide interests recently because of its antitumor activities. However, a superior bioavailability is required to achieve better efficacy due to its poor water solubility. The aim of this study was to enhance the evodiamine's aqueous solubility by preparing evodiamine/hydroxypropyl-β-cyclodextrin (EVO/HP-β-CD) inclusion complex, which is incorporated evodiamine into HP-β-CD, and compare the antitumor activities before and after inclusion with HP-β-CD in human hepatoma HepG2 cells...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27455219/antiproliferative-activity-and-cellular-uptake-of-evodiamine-and-rutaecarpine-based-on-3d-tumor-models
#16
Hui Guo, Dongmei Liu, Bin Gao, Xiaohui Zhang, Minli You, Hui Ren, Hongbo Zhang, Hélder A Santos, Feng Xu
Evodiamine (EVO) and rutaecarpine (RUT) are promising anti-tumor drug candidates. The evaluation of the anti-proliferative activity and cellular uptake of EVO and RUT in 3D multicellular spheroids of cancer cells would better recapitulate the native situation and thus better reflect an in vivo response to the treatment. Herein, we employed the 3D culture of MCF-7 and SMMC-7721 cells based on hanging drop method and evaluated the anti-proliferative activity and cellular uptake of EVO and RUT in 3D multicellular spheroids, and compared the results with those obtained from 2D monolayers...
July 21, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27449032/evodiamine-exerts-anti-tumor-effects-against-hepatocellular-carcinoma-through-inhibiting-%C3%AE-catenin-mediated-angiogenesis
#17
Le Shi, Fan Yang, Fei Luo, Yi Liu, Feng Zhang, Meijuan Zou, Qizhan Liu
Hepatocellular carcinoma (HCC) is a highly vascular tumor with high microvessel density and high levels of circulating vascular endothelial growth factor (VEGF). Thus, the angiogenesis pathway is an attractive therapeutic target for HCC. The anti-tumor effects of evodiamine, a quinolone alkaloid isolated from Euodia rutaecarpa (Juss.) Benth. (Rutaceae), were investigated in a mouse xenograft model using BALB/c nude mice, various HCC cell lines (HepG2, SMMC-7721, H22), and human umbilical vein endothelial cells (HUVECs)...
September 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27418289/qualitative-screening-of-absorbed-indoloquinazoline-alkaloids-and-their-metabolites-in-rat-plasma-after-the-oral-administration-of-wu-zhu-yu-decoction-by-high-resolution-mass-spectrometry-with-multiple-data-mining-algorithms
#18
Huarong Xu, Yajing Geng, Ran Liu, Ziyue Yuan, Xujia Liu, Qing Li, Kaishun Bi
A rapid and sensitive liquid chromatography with high-resolution mass spectrometry method with multiple data processing algorithms was developed and applied for the metabolite profiling of evodiamine and its analogous alkaloids in rat plasma after the administration of Wu-Zhu-Yu decoction. All samples were purified using hydrophilic-lipophilic balanced solid-phase extraction cartridges and analyzed by a Sciex TripleTOF 5600(+) mass spectrometer with a 35 min liquid chromatography gradient elution. High-resolution full-scan mass spectrometry and information-dependent acquisition tandem mass spectrometry data were analyzed using multiple data processing approaches...
August 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27402273/a-novel-alkaloid-evodiamine-causes-nuclear-localization-of-cytochrome-c-and-induces-apoptosis-independent-of-p53-in-human-lung-cancer-cells
#19
Vijay Mohan, Rajesh Agarwal, Rana P Singh
Lung cancer is the most frequently diagnosed malignancy that contributes to high proportion of deaths globally among patients who die due to cancer. Chemotherapy remains the common mode of treatment for lung cancer patients though with limited success. We assessed the biological effects and associated molecular changes of evodiamine, a plant alkaloid, on human lung cancer A549 and H1299 cells along with other epithelial cancer and normal lung SAEC cells. Our data showed that 20-40 μM evodiamine treatment for 24-48 h strongly (up to 73%, P < 0...
September 2, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27363277/-evodiamine-enhances-the-radiosensitivity-of-esophageal-squamous-cell-cancer-eca-109-cells
#20
Hui Feng, Baorui Guo, Xiangmei Kong, Biao Wu
Objective To investigate the effect of evodiamine on the radiosensitivity of esophageal squamous cell cancer Eca-109 cells. Methods Eca-109 cells were treated with various concentrations of evodiamine [(10, 20, 40, 60, 80, 100, 120) μg/mL], and then cell proliferation was examined by MTT assay. After the optimal evodiamine concentration was determined, the cells were divided into radiation group (0, 2, 4, 6, 8 Gy X-ray radiation) and radiation combined with evodiamine group (80 μg/mL evodiamine and 0, 2, 4, 6, 8 Gy X-ray radiation) ...
July 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
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