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Evodiamine

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https://www.readbyqxmd.com/read/28875323/evodiamine-inhibits-angiotensin-ii-induced-rat-cardiomyocyte-hypertrophy
#1
Na He, Qi-Hai Gong, Feng Zhang, Jing-Yi Zhang, Shu-Xian Lin, Hua-Hua Hou, Qin Wu, An-Sheng Sun
OBJECTIVE: To investigate the effects of evodiamine (Evo), a component of Evodiaminedia rutaecarpa Juss.) Benth, on cardiomyocyte hypertrophy induced by angiotensin II (Ang II) and further explore the potential mechanisms. METHODS: Cardiomyocytes from neonatal Sprague Dawley rats were isolated and characterized, and then the cadiomyocyte cultures were randomly divided into control, model (Ang II 0.1 μmol/L), and Evo (0.03, 0.3, 3 μmol/L) groups. The cardiomyocyte surface area, protein level, intracellular free calcium ([Ca(2+)]i) concentration, activity of nitric oxide synthase (NOS) and content of nitric oxide (NO) were measured, respectively...
September 5, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28841324/silver-nitrate-catalyzed-isocyanide-insertion-lactamization-sequence-to-imidazolones-and-quinazolin-4-ones-development-and-application-in-natural-product-synthesis
#2
Antonin Clemenceau, Qian Wang, Jieping Zhu
Silver nitrate-catalyzed reaction of methyl α,α-disubstituted α-isocyanoacetates with primary amines afforded 3,5,5-trisubstituted imidazolones in good to excellent yields. A silver salt-catalyzed insertion of the isocyano group into the N-H bond of the amine followed by in situ lactamization accounted for the reaction outcome. The same transformation between methyl 2-isocyanobenzoate and amines afforded quinazolin-4-ones in excellent yields. The utility of this chemistry was illustrated by the development of concise syntheses of (±)-evodiamine and rutaecarpine...
August 25, 2017: Organic Letters
https://www.readbyqxmd.com/read/28708106/evodiamine-exerts-an-anti-hepatocellular-carcinoma-activity-through-a-wwox-dependent-pathway
#3
Che-Yuan Hu, Hung-Tsung Wu, Yu-Chu Su, Ching-Han Lin, Chih-Jen Chang, Chao-Liang Wu
Evodiamine is one of the main components isolated from Evodia rutaecarpa, and it has been reported to exert inhibitory effects on cancers by anti-proliferative and apoptosis-inducing activities. Although the anti-cancer activity of evodiamine has been identified, the precise mechanisms of this action remain obscure. While previous studies indicated that evodiamine exerts anti-tumor effects through inhibiting β-catenin activity, and WW domain-containing oxidoreductase (WWOX) regulates β-catenin accumulation in cytoplasm, the effects of evodiamine on the expression of WWOX are still unknown...
July 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28598372/evaluation-of-the-cardiotoxicity-of-evodiamine-in-vitro-and-in-vivo
#4
Weifeng Yang, Lina Ma, Sidi Li, Kaiyu Cui, Lei Lei, Zuguang Ye
Evodiamine is a bioactive alkaloid that is specified as a biomarker for the quality assessment of Evodia rutaecarpa (E. rutaecarpa) and for traditional Chinese medicines containing this plant. We previously reported that quantitative structure-activity modeling indicated that evodiamine may cause cardiotoxicity. However, previous investigations have indicated that evodiamine has beneficial effects in patients with cardiovascular diseases and there are no previous in vitro or in vivo reports of evodiamine-induced cardiotoxicity...
June 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28571904/co-delivery-of-evodiamine-and-rutaecarpine-in-a-microemulsion-based-hyaluronic-acid-hydrogel-for-enhanced-analgesic-effects-on-mouse-pain-models
#5
Yong-Tai Zhang, Zhe Li, Kai Zhang, Hong-Yu Zhang, Ze-Hui He, Qing Xia, Ji-Hui Zhao, Nian-Ping Feng
The aim of this study was to improve the analgesic effect of evodiamine and rutaecarpine, using a microemulsion-based hydrogel (ME-Gel) as the transdermal co-delivery vehicle, and to assess hyaluronic acid as a hydrogel matrix for microemulsion entrapment. A microemulsion was formulated with ethyl oleate as the oil core to improve the solubility of the alkaloids and was loaded into a hyaluronic acid-structured hydrogel. Permeation-enhancing effects of the microemulsion enabled evodiamine and rutaecarpine in ME-Gel to achieve 2...
August 7, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28514905/evodiamine-prevents-glioma-growth-induces-glioblastoma-cell-apoptosis-and-cell-cycle-arrest-through-jnk-activation
#6
Wen-Shin Wu, Chih-Chiang Chien, Kao-Hui Liu, Yen-Chou Chen, Wen-Ta Chiu
Evodiamine (EVO) is an active medicinal compound derived from the traditional herbal medicine Evodia rutaecarpa. It has been reported that evodiamine has several beneficial biological properties, including anticancer and anti-inflammatory activities. However, the in vitro and in vivo anticancer activities of EVO against the growth of glioblastoma cells remain undefined. EVO induced significant decreases in the viability of U87 and C6 glioma cells, but not of primary astrocytes, according with the occurrence of apoptotic characteristics including DNA ladders, caspase-3 and poly(ADP ribose) polymerase (PARP) protein cleavage, and hypodiploid cells...
May 18, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28473656/efficient-intracellular-delivery-makes-cancer-cells-sensitive-to-nanoemulsive-chemodrugs
#7
Shan Liu, Dilong Chen, Yuming Yuan, Xue Zhang, Yao Li, Shenglei Yan, Jingqing Zhang
Evodiamine has been documented to possess activities in numerous cancer cells. Our preliminary study showed that A549 cells were insensitive to evodiamine. In this paper, A549 cells are sensitive to nanoemulsive evodiamine (EVONE) through an efficient intracellular and systematic delivery. EVONE entered tumor cells by energy-dependent and mainly through clathrin-mediated endocytosis. EVONE exerted a higher cytotoxicity in a dose- and time-dependent manner. The enhanced induction of cell cycle arrest was ascribed to the down-regulation of cyclin B and cyclin dependent kinase 1, while the enhanced induction of apoptosis was due to the activation of caspase -3, -8 and -9 and the decreased B-cell lymphoma 2/ assaciated X protein ratio...
April 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28337636/evodiamine-inhibits-zymosan-induced-inflammation-in-vitro-and-in-vivo-inactivation-of-nf-%C3%AE%C2%BAb-by-inhibiting-i%C3%AE%C2%BAb%C3%AE-phosphorylation
#8
Xia Fan, Jun-Yu Zhu, Yu Sun, Li Luo, Jun Yan, Xue Yang, Jing Yu, Wan-Qi Tang, Wei Ma, Hua-Ping Liang
Evodiamine (EVO), an important alkaloidal component extracted from the fruit of Evodiae fructus, has been known to possess anti-tumor, anti-inflammatory, anti-oxidative, and other therapeutic capabilities. In the present study, the effects of EVO on zymosan-induced inflammation and its underlying mechanism were investigated both in vitro and in vivo. Our results showed that EVO effectively suppressed both protein and mRNA expression of interleukin-1β, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in vitro...
March 23, 2017: Inflammation
https://www.readbyqxmd.com/read/28314276/evodiamine-induces-cell-growth-arrest-apoptosis-and-suppresses-tumorigenesis-in-human-urothelial-cell-carcinoma-cells
#9
Chung-Sheng Shi, Jhy-Ming Li, Chih-Chien Chin, Yi-Hung Kuo, Ying-Ray Lee, Yun-Ching Huang
BACKGROUND/AIM: Evodiamine, an indole alkaloid derived from Evodia rutaecarpa, exhibits pharmacological activities including vasodilatation, analgesia, anti-cardiovascular disease, anti-Alzheimer's disease, anti-inflammation, and anti-tumor activity. MATERIALS AND METHODS: This study analyzes the anti-tumor effects of evodiamine on cellular growth, tumorigenesis, cell cycle and apoptosis induction of human urothelial cell carcinoma (UCC) cells. RESULTS: The present study showed that evodiamine significantly inhibited the proliferation of UCC cells in a dose- and time-dependent manner...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28303407/evodiamine-attenuates-tgf-%C3%AE-1-induced-fibroblast-activation-and-endothelial-to-mesenchymal-transition
#10
Qing-Qing Wu, Yang Xiao, Xiao-Han Jiang, Yuan Yuan, Zheng Yang, Wei Chang, Zhou-Yan Bian, Qi-Zhu Tang
The aim of this study is to investigate the effect of evodiamine on fibroblast activation in cardiac fibroblasts and endothelial to mesenchymal transition (EndMT) in human umbilical vein endothelial cells (HUVECs). Neonatal rat cardiac fibroblasts were stimulated with transforming growth factor beta 1 (TGF-β1) to induce fibroblast activation. After co-cultured with evodiamine (5, 10 μM), the proliferation and pro-fibrotic proteins expression of cardiac fibroblasts were evaluated. HUVECs were also stimulated with TGF-β1 to induce EndMT and treated with evodiamine (5, 10 μM) at the same time...
March 16, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28219365/exploration-of-anti-cancer-effects-and-mechanisms-of-zuo-jin-wan-and-its-alkaloid-components-in-vitro-and-in-orthotopic-hepg2-xenograft-immunocompetent-mice
#11
Shun-Ting Chou, Chien-Yun Hsiang, Hsin-Yi Lo, Hui-Fen Huang, Ming-Tsung Lai, Ching-Liang Hsieh, Su-Yin Chiang, Tin-Yun Ho
BACKGROUND: Zuo-Jin-Wan (ZJW), a two-herb formula consisting of Coptis chinensis (CC) and Evodia rutaecarpa (ER), is commonly used in traditional Chinese medicine for the treatment of cancers. However, the efficacies and mechanisms of ZJW and its alkaloid components on cancers are still unclear. METHODS: Here we investigated the anti-cancer effects and mechanisms of ZJW, CC, ER, berberine, and evodiamine in cells and in intrahepatic xenograft mice. RESULTS: Treatment of HepG2 cells with ZJW, CC, ER, berberine, and evodiamine significantly displayed cytotoxic effects in a dose- and time-dependent manner...
February 20, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28190539/corrigendum-to-evodiamine-a-plant-alkaloid-induces-calcium-jnk-mediated-autophagy-and-calcium-mitochondria-mediated-apoptosis-in-human-glioblastoma-cells-chem-biol-interact-205-1-2013-sep-5-20-28
#12
Ann-Jeng Liu, Sheng-Hao Wang, Ku-Chung Chen, Hsiu-Ping Kuei, Yung-Luen Shih, Sz-Ying Hou, Wen-Ta Chiu, Sheng-Huang Hsiao, Chwen-Ming Shih
No abstract text is available yet for this article.
February 9, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28154330/analgesic-effects-and-side-effects-of-ephedra-herb-extract-and-ephedrine-alkaloids-free-ephedra-herb-extract
#13
REVIEW
Yoshinori Kobayashi
 Ephedra Herb is classified "pungent, slightly bitter, and warm" in tastes and natures, and is used to provide warmth to the body, dispel coldness, remove dampness, and reduce pain. Similar herbs are "pungent and hot" chili peppers, "pungent and hot" evodia fruit," "pungent and warm" ginger, "pungent and hot" processed ginger, "pungent and hot" Zanthoxylum fruit, etc. These herbs are prescribed to provide heat to the outer or inner body. Some pungent components such as capsaicin, evodiamine, gingerol, and shogaol are known to be activators of transient receptor potential vanilloid 1 (TRPV1)...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28146096/pharmacokinetics-studies-of-12-alkaloids-in-rat-plasma-after-oral-administration-of-zuojin-and-fan-zuojin-formulas
#14
Ping Qian, You-Bo Zhang, Yan-Fang Yang, Wei Xu, Xiu-Wei Yang
Zuojin formula (ZJ) is a traditional Chinese medicine (TCM) prescription consisted of Coptidis Rhizoma (CR) and Euodiae Fructus (EF), and has been used to treat gastrointestinal (GI) disease for more than 700 years. Fan-Zuojin formula (FZJ) is a related TCM prescription also consisted of CR and EF with the opposite proportion. In recent years, ZJ was getting more attention for its antitumor potential, but the indeterminate pharmacokinetic (PK) behavior restricted its clinical applications, and the PK differences between ZJ and FZJ were also largely unknown...
January 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28098901/effect-of-evodiamine-and-berberine-on-the-interaction-between-dnmts-and-target-micrornas-during-malignant-transformation-of-the-colon-by-tgf-%C3%AE-1
#15
Chao Huang, Hong Liu, Xiu-Li Gong, Li-Yun Wu, Bin Wen
The tissue microenvironment functions as a crucial player in carcinogenesis, and transforming growth factor-β1 (TGF-β1) within the microenvironment stimulates the formation of neoplasms. Using an in vitro model of malignancy induced by TGF-β1, we assessed the effect of evodiamine and berberine on the interaction between DNA methyltransferases (DNMTs) and target microRNAs (miRNAs) in the model. Colon tissues from neonatal rats 7 days of age were cultured and malignancy was induced by TGF-β1 in vitro for 48 h, and then the tissues were respectively treated with evodiamine and berberine for 24 h...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28010025/evodiamine-prevents-isoproterenol-induced-cardiac-fibrosis-by-regulating-endothelial-to-mesenchymal-transition
#16
Xiao-Han Jiang, Qing-Qing Wu, Yang Xiao, Yuan Yuan, Zheng Yang, Zhou-Yan Bian, Wei Chang, Qi-Zhu Tang
Evodiamine, a major component of Evodia rutaecarpa, can protect the myocardium against injury induced by atherosclerosis and ischemia-reperfusion. However, the effect of evodiamine against cardiac fibrosis remains unclear. This study aims to investigate the possible effect and mechanism involved in the function of evodiamine on isoproterenol-induced cardiac fibrosis and endothelial-to-mesenchymal transition. Isoproterenol was used to induce cardiac fibrosis in mice, and evodiamine was gavaged simultaneously...
June 2017: Planta Medica
https://www.readbyqxmd.com/read/27878250/sn38-increases-il-8-expression-through-the-mapk-pathways-in-hct8-cells
#17
Lei Zhang, Wen-Hui Lou, Xue-Feng Xu, Wenchuan Wu, Ye-Fei Rong, Da-Yong Jin
The overexpression of interleukin-8 (IL-8) is closely associated with poor tumor differentiation, metastasis and tumor progression. This study aimed to examine the effects and mechanisms of action of SN38 (a metabolite of the camptothecin derivative, CPT-11) on IL-8 expression in HCT8 cells, using ELISA, CCK-8 and western blot analysis. Among jatrorrhizine, evodiamine, 5-fluorouracil and SN38, SN38 was found to inhibit the proliferation of HCT8 cells in a dose-dependent manner, but to increase IL-8 secretion from HCT8 cells...
January 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27848250/pharmacological-effects-of-active-components-of-chinese-herbal-medicine-in-the-treatment-of-alzheimer-s-disease-a-review
#18
REVIEW
Zhi-Yong Wang, Jian-Gang Liu, Hao Li, Hui-Ming Yang
Alzheimer's disease (AD), the most common neurodegenerative disorder associated with dementia, not only severely decreases the quality of life for its victims, but also brings a heavy economic burden to the family and society. Unfortunately, few chemical drugs designed for clinical applications have reached the expected preventive or therapeutic effect so far, and combined with their significant side-effects, there is therefore an urgent need for new strategies to be developed for AD treatment. Traditional Chinese Medicine has accumulated many experiences in the treatment of dementia during thousands of years of practice; modern pharmacological studies have confirmed the therapeutic effects of many active components derived from Chinese herbal medicines (CHM)...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27771931/evodiamine-and-its-role-in-chronic-diseases
#19
REVIEW
Qunyou Tan, Jingqing Zhang
Evodiamine (EVO) is a major alkaloid compound extracted from the dry unripened fruit Evodiae fructus (Evodia rutaecarpa Benth., Rutaceae). EVO has a variety of pharmacological activities, such as anti-obesity, anti-allergenic, analgesic, anti-tumor, anti-ulcerogenic, and neuroprotective activities. EVO has varying efficacies in animal models and humans. Here, the physicochemical properties of EVO are presented, and the EVO's functions and mechanisms of action in various chronic diseases are reviewed. EVO is worth exploring in more depth in the future for its potential use in various chronic diseases...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27748810/evodiamine-inhibits-pdgf%C3%A2-bb%C3%A2-induced-proliferation-of-rat-vascular-smooth-muscle-cells-through-the-suppression-of-cell-cycle-progression-and-oxidative-stress
#20
Xie Ge, Si-Yu Chen, Mei Liu, Ting-Ming Liang, Chang Liu
Vascular smooth muscle cell (VSMC) proliferation is a key event in the development of in‑stent restenosis. Evodiamine is an indole alkaloid extracted from the Chinese medicine, evodia, and has been shown to inhibit tumor cell proliferation and protect the cardiovascular system. However, whether evodiamine affects VSMC proliferation remains to be elucidated. Therefore, the present study examined the effects and the mechanisms of action of evodiamine on the proliferation of rat VSMCs. The cells were treated with evodiamine alone or in combination with platelet‑derived growth factor‑BB (PDGF‑BB) stimulation...
November 2016: Molecular Medicine Reports
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