Juliana Silva Siqueira, Jessica Leite Garcia, Artur Junio Togneri Ferron, Fernando Moreto, Luis Eduardo Sormani, Mariane Rovero Costa, Thiago Luiz Novaga Palacio, Gisele Alborghetti Nai, Giancarlo Aldini, Fabiane Valentini Francisqueti-Ferron, Camila Renata Correa, Alfonsina D'Amato
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease associated with obesity and diabetes prevalence. The use of natural compounds has become an attractive approach to prevent NAFLD and its progression. Gamma-oryzanol (Orz) is a natural compound whose beneficial effects on chronic metabolic diseases have been reported. Therefore, we aimed to investigate the preventive effect of Orz on the hepatic proteome in a diet induced NAFLD model. Wistar rats were randomly distributed into three experimental groups (n = 6/group) according to the diet received for 30 weeks: Control group, high sugar-fat (HSF) group, and HSF + Orz group...
March 1, 2024: Journal of Nutritional Biochemistry