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https://www.readbyqxmd.com/read/28715153/automated-analysis-of-fetal-cardiac-function-using-color-tissue-doppler-imaging
#1
L Herling, J Johnson, K Ferm-Widlund, F Bergholm, P Lindgren, S-E Sonesson, G Acharya, M Westgren
OBJECTIVES: Our main objective was to evaluate the feasibility of an automated analysis of fetal myocardial velocity recordings obtained by color tissue Doppler imaging (cTDI). METHODS: This was a prospective cross-sectional observational study of 107 singleton pregnancies in ≥41 weeks of gestation. Myocardial velocity recordings were obtained by cTDI in a long-axis four-chamber view of the fetal heart. Regions of interest (ROI) were placed in the septum, right (RV) and left ventricular (LV) walls at the level of the atrioventricular plane (AV-plane)...
July 17, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28714774/small-sided-games-in-elite-soccer-does-one-size-fits-all
#2
Mathieu Lacome, Ben M Simpson, Yannick Cholley, Philippe Lambert, Martin Buchheit
PURPOSE: To compare the peak intensity of typical Small Sided Games (SSGs) with those of official matches in terms of running demands and mechanical work over different rolling average durations and playing positions. METHOD: Data were collected in 21 players (25±5 y, 181±7 cm, 77±7 kg) belonging to an elite French football team. SSG data were collected over two seasons during typical training sessions (249 files, 12±4 per player) and official matches (n=12)...
July 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28714264/response-surface-methodology-based-on-central-composite-design-accompanied-by-multivariate-curve-resolution-to-model-gradient-hydrophilic-interaction-liquid-chromatography-prediction-of-separation-for-five-major-opium-alkaloids
#3
Mohammadreza Taheri, Mohsen Bagheri, Roudabeh Sadat Moazeni-Pourasil, Alireza Ghassempour
Hydrophilic interaction liquid chromatography on bare silica presents some benefits for analysis and purification of ionizable basic alkaloids. This method was used to separate five major opium alkaloids: morphine, codeine, thebaine, papaverine, and noscapine. Central composite design based on response surface methodology was applied for experimental design, modeling, and optimization in a single-step gradient method. The main effects and their interactions (initial percentage of modifier, changing range of modifier in run time, pH of buffer, and its concentration) were investigated in 30 experiments...
July 17, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28711758/assessing-the-binding-of-cholinesterase-inhibitors-by-docking-and-molecular-dynamics-studies
#4
M Rejwan Ali, Mostafa Sadoqi, Simon G Møller, Allal Boutajangout, Mihaly Mezei
In this report we assessed by docking and molecular dynamics the binding mechanisms of three FDA-approved Alzheimer drugs, inhibitors of the enzyme acetylcholinesterase (AChE): donepezil, galantamine and rivastigmine. Dockings by the softwares Autodock-Vina, PatchDock and Plant reproduced the docked conformations of the inhibitor-enzyme complexes within 2Å of RMSD of the X-ray structure. Free-energy scores show strong affinity of the inhibitors for the enzyme binding pocket. Three independent Molecular Dynamics simulation runs indicated general stability of donepezil, galantamine and rivastigmine in their respective enzyme binding pocket (also referred to as gorge) as well as the tendency to form hydrogen bonds with the water molecules...
June 29, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28710665/physical-exercise-reduces-pyruvate-carboxylase-pcb-and-contributes-to-hyperglycemia-reduction-in-obese-mice
#5
Vitor Rosetto Muñoz, Rafael Calais Gaspar, Barbara Moreira Crisol, Guilherme Pedron Formigari, Marcella Ramos Sant'Ana, José Diego Botezelli, Rodrigo Stellzer Gaspar, Adelino S R da Silva, Dennys Esper Cintra, Leandro Pereira de Moura, Eduardo Rochete Ropelle, José Rodrigo Pauli
The present study evaluated the effects of exercise training on pyruvate carboxylase protein (PCB) levels in hepatic tissue and glucose homeostasis control in obese mice. Swiss mice were distributed into three groups: control mice (CTL), fed a standard rodent chow; diet-induced obesity (DIO), fed an obesity-inducing diet; and a third group, which also received an obesity-inducing diet, but was subjected to an exercise training protocol (DIO + EXE). Protocol training was carried out for 1 h/d, 5 d/wk, for 8 weeks, performed at an intensity of 60% of exhaustion velocity...
July 14, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28705996/different-gene-response-to-mechanical-loading-during-early-and-late-phases-of-rat-achilles-tendon-healing
#6
Malin Hammerman, Parmis Blomgran, Arie Dansac, Pernilla Eliasson, Per Aspenberg
Mechanical loading stimulates tendon healing both when applied in the inflammatory phase and in the early remodeling phase of the process, although not necessarily via the same mechanisms. We investigated the gene response to mechanical loading in these two phases of tendon healing. The right Achilles tendon in rats was transected and the hind limbs were unloaded by tail suspension. The rats were exposed to 5 minutes of treadmill running 3 or 14 days after tendon transection. Thereafter, they were re-suspended for 15 minutes or 3 hours until euthanasia...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28700655/cyclophosphamide-leads-to-persistent-deficits-in-physical-performance-and-in-vivo-mitochondria-function-in-a-mouse-model-of-chemotherapy-late-effects
#7
Marie-Laure Crouch, Gary Knowels, Rudolph Stuppard, Nolan G Ericson, Jason H Bielas, David J Marcinek, Karen L Syrjala
Fatigue is the symptom most commonly reported by long-term cancer survivors and is increasingly recognized as related to skeletal muscle dysfunction. Traditional chemotherapeutic agents can cause acute toxicities including cardiac and skeletal myopathies. To investigate the mechanism by which chemotherapy may lead to persistent skeletal muscle dysfunction, mature adult mice were injected with a single cyclophosphamide dose and evaluated for 6 weeks. We found that exposed mice developed a persistent decrease in treadmill running time compared to baseline (25...
2017: PloS One
https://www.readbyqxmd.com/read/28700618/micro-finite-element-models-of-the-vertebral-body-validation-of-local-displacement-predictions
#8
Maria Cristiana Costa, Gianluca Tozzi, Luca Cristofolini, Valentina Danesi, Marco Viceconti, Enrico Dall'Ara
The estimation of local and structural mechanical properties of bones with micro Finite Element (microFE) models based on Micro Computed Tomography images depends on the quality bone geometry is captured, reconstructed and modelled. The aim of this study was to validate microFE models predictions of local displacements for vertebral bodies and to evaluate the effect of the elastic tissue modulus on model's predictions of axial forces. Four porcine thoracic vertebrae were axially compressed in situ, in a step-wise fashion and scanned at approximately 39μm resolution in preloaded and loaded conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28699898/marcks-promotes-invasion-and-is-associated-with-biochemical-recurrence-in-prostate-cancer
#9
Emma Dorris, Amanda O'Neill, Karen Hanrahan, Ann Treacy, R William Watson
BACKGROUND: Overtreatment of low-grade prostate cancer is a recognised problem for clinicians and patients. However, under-treatment runs the risk of missing the opportunity for cure in those who could benefit. Identification of new biomarkers of disease progression, including metastases, is required to better stratify and appropriately treat these patients. The ability to predict if prostate cancer will recur is an important clinical question that would impact treatment options for patients...
June 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28697691/the-relationship-between-mechanical-stiffness-and-athletic-performance-markers-in-sub-elite-footballers
#10
Judd T Kalkhoven, Mark L Watsford
This study investigated the relationship between several measures of lower-body stiffness and physical performance variables in 22 sub-elite male football players (mean ± SD; 21.9 ± 1.5 yr; 1.79 ± 0.06 m; 72.2 ± 7.2 kg). The participants were assessed for individual muscle stiffness of the Rectus Femoris (RF), Biceps Femoris (BF) and Medial Gastrocnemius (MG) muscles and vertical stiffness (Kvert) was also assessed assessed running acceleration, maximal sprint speed, agility, vertical jumping and muscular strength...
July 12, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28690636/forks-on-the-run-can-the-stalling-of-dna-replication-promote-epigenetic-changes
#11
REVIEW
Hollie Rowlands, Piriththiv Dhavarasa, Ashley Cheng, Krassimir Yankulov
Built of DNA polymerases and multiple associated factors, the replication fork steadily progresses along the DNA template and faithfully replicates DNA. This model can be found in practically every textbook of genetics, with the more complex situation of chromatinized DNA in eukaryotes often viewed as a variation. However, the replication-coupled disassembly/reassembly of chromatin adds significant complexity to the whole replication process. During the course of eukaryotic DNA replication the forks encounter various conditions and numerous impediments...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28690549/running-economy-from-a-muscle-energetics-perspective
#12
REVIEW
Jared R Fletcher, Brian R MacIntosh
The economy of running has traditionally been quantified from the mass-specific oxygen uptake; however, because fuel substrate usage varies with exercise intensity, it is more accurate to express running economy in units of metabolic energy. Fundamentally, the understanding of the major factors that influence the energy cost of running (Erun) can be obtained with this approach. Erun is determined by the energy needed for skeletal muscle contraction. Here, we approach the study of Erun from that perspective...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28688765/ctrp9-regulates-hypoxia-mediated-human-pulmonary-artery-smooth-muscle-cell-proliferation-apoptosis-and-migration-via-tgf-%C3%AE-1-erk1-2-signaling-pathway
#13
Yong Xin Li, Lin Run, Tao Shi, Yong Jian Zhang
Hypoxia is an important risk factor for pulmonary arterial remodeling in pulmonary arterial hypertension (PAH). Vascular remodeling in hypoxia-induced PAH is driven by excessive proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs). The purpose of the present study was to explore the expression of CTRP9 in rats model of hypoxia-induced PAH and investigate the effects of CTRP9 on HPASMCs function in vitro and determine the underlying mechanisms. We established a rat model of hypoxic PAH, which showed an downregulation of CTRP9 expression...
July 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28685262/urinary-leakage-during-exercise-problematic-activities-adaptive-behaviors-and-interest-in-treatment-for-physically-active-canadian-women
#14
Erin Brennand, Eider Ruiz-Mirazo, Selphee Tang, Shunaha Kim-Fine
INTRODUCTION AND HYPOTHESIS: Urine loss during recreational exercise is problematic. We aimed to characterize which activities are most frequently reported as causing leakage for women, adaptive management mechanisms, and awareness and interest in treatment in a cohort of physically active women. METHODS: We administered an anonymous questionnaire to 59 physically active women in Canada. Surveys were completed electronically or on paper. Demographic information was obtained...
July 6, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28685109/zno-nanoparticles-sensitized-by-cuinzn-x-s2-x-quantum-dots-as-highly-efficient-solar-light-driven-photocatalysts
#15
Florian Donat, Serge Corbel, Halima Alem, Steve Pontvianne, Lavinia Balan, Ghouti Medjahdi, Raphaël Schneider
Alloyed CuInZn x S2+x (ZCIS) quantum dots (QDs) were successfully associated to ZnO nanoparticles by a thermal treatment at 400 °C for 15 min. The ZnO/ZCIS composite was characterized by TEM, SEM, XRD, XPS and UV-vis absorption spectroscopy. ZCIS QDs, with an average diameter of ≈4.5 nm, were found to be homogeneously distributed at the surface of ZnO nanoparticles. ZCIS-sensitized ZnO nanoparticles exhibit a high photocatalytic activity under simulated solar light irradiation for the degradation of Orange II dye (>95% degradation after 180 min of irradiation at an intensity of 5 mW/cm(2))...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28683303/cellular-changes-of-stem-cells-in-3-dimensional-culture
#16
Matthew P Green, Bo Hou
PURPOSE: During various operations and procedures, such as distraction osteogenesis and orthodontics, skeletal tissues use mechanotransduction. Mechanotransduction is important for maintaining bone health and converting mechanical forces into biochemical signals. We hypothesized that cells put under mechanical stress would adapt and change morphologically and respond with a decrease in cellular proliferation to accommodate the stress differences. These differences will be measured at the molecular and genetic level...
June 12, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28683292/mice-under-caloric-restriction-self-impose-a-temporal-restriction-of-food-intake-as-revealed-by-an-automated-feeder-system
#17
Victoria A Acosta-Rodríguez, Marleen H M de Groot, Filipa Rijo-Ferreira, Carla B Green, Joseph S Takahashi
Caloric restriction (CR) extends lifespan in mammals, yet the mechanisms underlying its beneficial effects remain unknown. The manner in which CR has been implemented in longevity experiments is variable, with both timing and frequency of meals constrained by work schedules. It is commonplace to find that nocturnal rodents are fed during the daytime and meals are spaced out, introducing prolonged fasting intervals. Since implementation of feeding paradigms over the lifetime is logistically difficult, automation is critical, but existing systems are expensive and not amenable to scale...
July 5, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28680450/an-erchen-and-yinchen-decoction-ameliorates-high-fat-induced-nonalcoholic-steatohepatitis-in-rats-by-regulating-jnk1-signaling-pathway
#18
Tian-Hong Xie, Jun-Xiang Li, Tang-You Mao, Yi Guo, Chen Chen, Ya-Fei Han, Xiang Tan, Run-Hua Chen
ErChen and YinChen decoction (ECYCD) is an effective traditional Chinese medicine and has been widely used in traditional Chinese medicine to treat nonalcoholic steatohepatitis (NASH), with good curative effects. However, the specific mechanisms underlying these effects are unclear. In this study, we determined the efficacy of ECYCD in a high-fat diet-induced NASH rat model, established by 8-week administration of a high-fat diet. ECYCD was administered daily for 4 weeks, after which the rats were euthanized...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28679078/structural-modelling-and-molecular-dynamics-of-a-multi-stress-responsive-wrky-tf-dna-complex-towards-elucidating-its-role-in-stress-signalling-mechanisms-in-chickpea
#19
Aravind Kumar Konda, Rohit Farmer, Khela Ram Soren, P S Shanmugavadivel, Aravind Setti
Chickpea is a premier food legume crop with high nutritional quality and attains prime importance in the current era of 795 million people being undernourished worldwide. Chickpea production encounters setbacks due to various stresses and understanding the role of key transcription factors involved in multiple stresses becomes inevitable. We have recently identified a multi-stress responsive WRKY transcription factor (TF) in chickpea. The present study was conducted to predict the structure of WRKY TF to identify the DNA interacting residues and decipher DNA-protein interactions...
July 5, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28678180/mph-m-aodv-m-and-dsr-m-performance-evaluation-under-jamming-attacks
#20
Carolina Del-Valle-Soto, Carlos Mex-Perera, Raul Monroy, Juan A Nolazco-Flores
In this work, we present the design of a mitigation scheme for jamming attacks integrated to the routing protocols MPH, AODV, and DSR. The resulting protocols are named MPH-M (Multi-Parent Hierarchical - Modified), AODV-M (Ad hoc On Demand Distance Vector - Modified), and DSR-M (Dynamic Source Routing - Modified). For the mitigation algorithm, if the detection algorithm running locally in each node produces a positive result then the node is isolated; second, the routing protocol adapts their paths avoiding the isolated nodes...
July 5, 2017: Sensors
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