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https://www.readbyqxmd.com/read/28342723/effects-of-eccentric-overload-training-on-patellar-tendon-and-vastus-lateralis-in-three-days-of-consecutive-running
#1
Fernando Sanz-López, César Berzosa, Fidel Hita-Contreras, Antonio Martínez-Amat
BACKGROUND: The analysis of structural changes in patellar tendon and muscle of healthy subjects in response to mechanical loads provides useful insight into the mechanism underlying overuse injuries. METHODS: Changes produced in tendon and muscles structures after eccentric overload training and three consecutive running days were examined. Twenty healthy subjects were recruited and divided into two groups. One group (ECC) performed eccentric overload squat training (six weeks)...
March 22, 2017: Knee
https://www.readbyqxmd.com/read/28340126/association-between-socioeconomic-status-and-access-to-care-and-quitting-smoking-with-and-without-assistance
#2
Sarah A Edwards, Russell C Callaghan, Robert E Mann, Susan J Bondy
Introduction: Socio-economic disparities in smoking rates persist, in Ontario, despite public health care and universal tobacco control policies. Mechanisms for continuing disparities are not fully understood. Unequal access or utilization of assistance for cessation may contribute. The objective of this research was to use longitudinal data on smokers to examine the associations between socioeconomic status (SES) and access to care measures and assisted and unassisted quit attempts. Methods: Data were taken from 3578 smokers with at least one follow-up interview participating in the Ontario Tobacco Survey (OTS)...
March 10, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28338382/does-foot-anthropometry-predict-metabolic-cost-during-running
#3
Herman van Werkhoven, Stephen J Piazza
Several recent investigations have linked running economy to heel length, with shorter heels being associated with less metabolic energy consumption. It has been hypothesized that shorter heels require larger plantarflexor muscle forces, thus increasing tendon energy storage and reducing metabolic cost. The goal of this study was to investigate this possible mechanism for metabolic cost reduction. Fifteen male subjects ran at 16 km·h(-1) on a treadmill and subsequently on a force-plate instrumented runway...
March 24, 2017: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/28337159/hey-teacher-don-t-leave-them-kids-alone-action-is-better-for-memory-than-reading
#4
Mathieu Hainselin, Laurence Picard, Patrick Manolli, Sophie Vankerkore-Candas, Béatrice Bourdin
There is no consensus on how the enactment effect (EE), although it is robust, enhances memory. Researchers are currently investigating the cognitive processes underlying this effect, mostly during adulthood; the link between EE and crucial function identified in adulthood such as episodic memory and binding process remains elusive. Therefore, this study aims to verify the existence of EE in 6-10 years old and assess cognitive functions potentially linked to this effect in order to shed light on the mechanisms underlying the EE during childhood...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28337151/a-reduction-in-maximal-incremental-exercise-test-duration-48-h-post-downhill-run-is-associated-with-muscle-damage-derived-exercise-induced-pain
#5
Bryna C R Chrismas, Lee Taylor, Jason C Siegler, Adrian W Midgley
Purpose: To examine whether exercise induced muscle damage (EIMD) and muscle soreness reduce treadmill maximal incremental exercise (MIE) test duration, and true maximal physiological performance as a consequence of exercise induced pain (EIP) and perceived effort. Methods: Fifty (14 female), apparently healthy participants randomly allocated into a control group (CON, n = 10), or experimental group (EXP, n = 40) visited the laboratory a total of six times: visit 1 (familiarization), visit 2 (pre 1), visit 3 (pre 2), visit 4 (intervention), visit 5 (24 h post) and visit 6 (48 h post)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28336940/genetic-analysis-of-the-incx4-plasmids-implications-for-a-unique-pattern-in-the-mcr-1-acquisition
#6
Jian Sun, Liang-Xing Fang, Zuowei Wu, Hui Deng, Run-Shi Yang, Xing-Ping Li, Shu-Min Li, Xiao-Ping Liao, Youjun Feng, Ya-Hong Liu
IncX4 plasmids are associated with the dissemination of the mcr-1 genes in Enterobacteriaceae. We screened IncX4 plasmids among 2,470 isolates of Enterobacteriaceae and determined the mcr-1 positive isolates. Forty-three isolates were observed to carry IncX4 type plasmid, among which 13 were identified to carry mcr-1 gene. Three representative mcr-1-positive IncX4 plasmids were selected for high-throughput sequencing. Comparative genomics showed that the mcr-1-carrying IncX4 plasmids exhibit remarkable similarity in the backbone, and the major distinction lies in the region containing mcr-1...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28334424/frequency-and-function-in-the-basal-ganglia-the-origins-of-beta-and-gamma-band-activity
#7
Alexander Blenkinsop, Sean Anderson, Kevin Gurney
Neural oscillations in the basal ganglia are well studied yet remain poorly understood. Behavioural correlates of spectral activity are well described, yet a quantitative hypothesis linking time domain dynamics and spectral properties to basal ganglia function has been lacking. We show, for the first time, that a unified description is possible by interpreting previously ignored structure in data describing GPi responses to cortical stimulation. These data were used to expose a pair of distinctive neuronal responses to the stimulation...
March 23, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28334340/meta-analytic-framework-for-liquid-association
#8
Lin Wang, Silvia Liu, Ying Ding, Shin-Sheng Yuan, Yen-Yi Ho, George C Tseng
Motivation: Although coexpression analysis via pair-wise expression correlation is popularly used to elucidate gene-gene interactions at the whole-genome scale, many complicated multi-gene regulations require more advanced detection methods. Liquid association is a powerful tool to detect the dynamic correlation of two gene variables depending on the expression level of a third variable (LA scouting gene). Liquid association detection from single transcriptomic study, however, is often unstable and not generalizable due to cohort bias, biological variation, and limited sample size...
March 11, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28334286/differences-in-the-photosynthetic-plasticity-of-ferns-and-ginkgo-grown-in-experimentally-controlled-low-o2-co2-atmospheres-may-explain-their-contrasting-ecological-fate-across-the-triassic-jurassic-mass-extinction-boundary
#9
C Yiotis, C Evans-Fitz Gerald, J C McElwain
Background and Aims: Fluctuations in [CO 2 ] have been widely studied as a potential driver of plant evolution; however, the role of a fluctuating [O 2 ]:[CO 2 ] ratio is often overlooked. The present study aimed to investigate the inherent physiological plasticity of early diverging, extant species following acclimation to an atmosphere similar to that across the Triassic-Jurassic mass extinction interval (TJB, approx. 200 Mya), a time of major ecological change. Methods: Mature plants from two angiosperm ( Drimys winteri and Chloranthus oldhamii ), two monilophyte ( Osmunda claytoniana and Cyathea australis ) and one gymnosperm ( Ginkgo biloba ) species were grown for 2 months in replicated walk-in Conviron BDW40 chambers running at TJB treatment conditions of 16 % [O 2 ]-1900 ppm [CO 2 ] and ambient conditions of 21 % [O 2 ]-400 ppm [CO 2 ], and their physiological plasticity was assessed using gas exchange and chlorophyll fluorescence methods...
March 11, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28332113/the-critical-power-concept-applications-to-sports-performance-with-a-focus-on-intermittent-high-intensity-exercise
#10
REVIEW
Andrew M Jones, Anni Vanhatalo
The curvilinear relationship between power output and the time for which it can be sustained is a fundamental and well-known feature of high-intensity exercise performance. This relationship 'levels off' at a 'critical power' (CP) that separates power outputs that can be sustained with stable values of, for example, muscle phosphocreatine, blood lactate, and pulmonary oxygen uptake ([Formula: see text]), from power outputs where these variables change continuously with time until their respective minimum and maximum values are reached and exercise intolerance occurs...
March 22, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28330449/a-cross-sectional-study-of-the-effects-of-load-carriage-on-running-characteristics-and-tibial-mechanical-stress-implications-for-stress-fracture-injuries-in-women
#11
Chun Xu, Amy Silder, Ju Zhang, Jaques Reifman, Ginu Unnikrishnan
BACKGROUND: Load carriage is associated with musculoskeletal injuries, such as stress fractures, during military basic combat training. By investigating the influence of load carriage during exercises on the kinematics and kinetics of the body and on the biomechanical responses of bones, such as the tibia, we can quantify the role of load carriage on bone health. METHODS: We conducted a cross-sectional study using an integrated musculoskeletal-finite-element model to analyze how the amount of load carriage in women affected the kinematics and kinetics of the body, as well as the tibial mechanical stress during running...
March 23, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28330072/molecular-dynamic-simulations-of-escherichia-coli-l-asparaginase-to-illuminate-its-role-in-deamination-of-asparagine-and-glutamine-residues
#12
Rajeswara Reddy Erva, Satish Babu Rajulapati, Chandrasai Potla Durthi, Mayuri Bhatia, Madhuri Pola
Acute lymphocytic leukemia (ALL) is an outrageous disease worldwide. L-Asparagine (L-Asn) and L-Glutamine (L-Gln) deamination play a crucial role in ALL treatment. Role of Elspar(®) (L-asparaginase from Escherichia coli) in regulation of L-Asn and L-Gln has been confirmed by the other researchers through experimental studies. Therapeutic research against ALL remained elusive with the lack of information on molecular interactions of Elspar(®) with amino acid substrates. In the present study, using different docking tools binding cavities, key residues in binding and ligand binding mechanisms were identified...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329441/a-framework-for-the-etiology-of-running-related-injuries
#13
REVIEW
M L Bertelsen, A Hulme, J Petersen, R Korsgaard Brund, H Sørensen, C F Finch, E T Parner, R O Nielsen
The etiology of running-related injury is important to consider as the effectiveness of a given running-related injury prevention intervention is dependent on whether etiologic factors are readily modifiable and consistent with a biologically plausible causal mechanism. Therefore, the purpose of the present article was to present an evidence-informed conceptual framework outlining the multifactorial nature of running-related injury etiology. In the framework, four mutually exclusive parts are presented: (A) Structure-specific capacity when entering a running session; (B) Structure-specific cumulative load per running session; (C) Reduction in the structure-specific capacity during a running session; and, (D) Exceeding the structure-specific capacity...
March 22, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28329071/association-of-mild-obstructive-sleep-apnea-with-cognitive-performance-excessive-daytime-sleepiness-and-quality-of-life-in-the-general-population-the-korean-genome-and-epidemiology-study-koges
#14
Hyun Kim, Robert J Thomas, Chang-Ho Yun, Rhoda Au, Seung Ku Lee, Sunghee Lee, Chol Shin
Study Objectives: Research points to impaired cognitive performance in sleep clinic patients with obstructive sleep apnea (OSA). However, inconsistent findings from various epidemiologic studies make this relationship less generalizable. The current study investigated the association between OSA functional outcome measures, such as cognition, daytime sleepiness, and quality of life, in a Korean general population sample. Methods: A total of 1,492 participants from the Korean Genome and Epidemiology Study (KoGES) were included in the analyses...
January 28, 2017: Sleep
https://www.readbyqxmd.com/read/28328219/energy-storage-during-compression-of-metal-organic-frameworks
#15
Yu-Run Miao, Zhi Su, Kenneth S Suslick
Practical applications of metal-organic framework (MOF) materials require an in-depth understanding of their mechanical properties. We have investigated the mechanical properties and energy absorption behavior of single crystals of four isostructural UiO-type MOFs under uniaxial compression. In situ nanocompression experiments were used to measure the mechanical behavior of individual MOF nanocrystals under compression within a transmission electron microscope. The plasticity and endothermicity during deformation of MOFs shows a surprising potential for absorption and dissipation of mechanical shock...
March 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28327935/science-in-the-cloud-sic-a-use-case-in-mri-connectomics
#16
Gregory Kiar, Krzysztof J Gorgolewski, Dean Kleissas, William Gray Roncal, Brian Litt, Brian Wandell, Russel A Poldrack, Martin Wiener, R Jacob Vogelstein, Randal Burns, Joshua T Vogelstein
Modern technologies are enabling scientists to collect extraordinary amounts of complex and sophisticated data across a huge range of scales like never before. With this onslaught of data, we can allow the focal point to shift from data collection to data analysis. Unfortunately, lack of standardized sharing mechanisms and practices often make reproducing or extending scientific results very difficult. With the creation of data organization structures and tools which drastically improve code portability, we now have the opportunity to design such a framework for communicating extensible scientific discoveries...
March 7, 2017: GigaScience
https://www.readbyqxmd.com/read/28326933/attenuation-of-hyperalgesia-responses-via-the-modulation-of-5-hydroxytryptamine-signalings-in-the-rostral-ventromedial-medulla-and-spinal-cord-in-a-6-hydroxydopamine-induced-rat-model-of-parkinson-s-disease
#17
Chen-Tao Wang, Cheng-Jie Mao, Xiao-Qi Zhang, Cai-Yi Zhang, Dong-Jun Lv, Ya-Ping Yang, Kai-Lin Xia, Jun-Yi Liu, Fen Wang, Li-Fang Hu, Guang-Yin Xu, Chun-Feng Liu
Background Although pain is one of the most distressing non-motor symptoms among patients with Parkinson's disease, the underlying mechanisms of pain in Parkinson's disease remain elusive. The aim of the present study was to investigate the role of serotonin (5-hydroxytryptamine) in the rostral ventromedial medulla (RVM) and spinal cord in pain sensory abnormalities in a 6-hydroxydopamine-treated rat model of Parkinson's disease. Methods The rotarod test was used to evaluate motor function. The radiant heat test and von Frey test were conducted to evaluate thermal and mechanical pain thresholds, respectively...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28322236/the-role-of-mesolimbic-reward-neurocircuitry-in-prevention-and-rescue-of-the-activity-based-anorexia-aba-phenotype-in-rats
#18
Claire J Foldi, Laura K Milton, Brian J Oldfield
Patients suffering anorexia nervosa (AN) become anhedonic; unable or unwilling to derive normal pleasures and avoid rewarding outcomes, most profoundly in food intake. The activity-based anorexia (ABA) model recapitulates many of the characteristics of the human condition, including anhedonia, and allows investigation of the underlying neurobiology of AN. The potential for increased neuronal activity in reward/hedonic circuits to prevent and rescue weight loss is investigated in this model. The mesolimbic pathway extending from the ventral tegmental area (VTA) to the nucleus accumbens (NAc) was activated using a dual viral strategy, involving retrograde transport of Cre (CAV2-Cre) to the VTA and coincident injection of DREADD receptors (AAV-hSyn-DIO-hM3D(Gq)-mCherry)...
March 21, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28318224/defects-mediated-corrosion-in-graphene-coating-layer
#19
Jincheng Lei, Yaowu Hu, Zishun Liu, Gary J Cheng, Kejie Zhao
Mixed results were reported on the anticorrosion of graphene-coated metal surfaces-while graphene serves as an effective short-term barrier against corrosion and oxidation due to its low permeability to gases, the galvanic cell between graphene and the metal substrate facilitates extensive corrosion in the long run. Defects in the graphene layer provide pathways for the permeation of oxidizing species. We study the role of defects in graphene in the anticorrosion using first-principles theoretical modeling...
March 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28316598/t-cell-receptor-and-cytokine-signaling-can-function-at-different-stages-to-establish-and-maintain-transcriptional-memory-and-enable-t-helper-cell-differentiation
#20
REVIEW
Sarah L Bevington, Pierre Cauchy, David R Withers, Peter J L Lane, Peter N Cockerill
Experienced T cells exhibit immunological memory via a rapid recall response, responding to restimulation much faster than naïve T cells. The formation of immunological memory starts during an initial slow response, when naïve T cells become transformed to proliferating T blast cells, and inducible immune response genes are reprogrammed as active chromatin domains. We demonstrated that these active domains are supported by thousands of priming elements which cooperate with inducible transcriptional enhancers to enable efficient responses to stimuli...
2017: Frontiers in Immunology
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