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https://www.readbyqxmd.com/read/28654039/electrophysiological-method-for-whole-cell-voltage-clamp-recordings-from-drosophila-photoreceptors
#1
Ben Katz, Rita Gutorov, Elisheva Rhodes-Mordov, Roger C Hardie, Baruch Minke
Whole-cell voltage clamp recordings from Drosophila melanogaster photoreceptors have revolutionized the field of invertebrate visual transduction, enabling the use of D. melanogaster molecular genetics to study inositol-lipid signaling and Transient Receptor Potential (TRP) channels at the single-molecule level. A handful of labs have mastered this powerful technique, which enables the analysis of the physiological responses to light under highly controlled conditions. This technique allows control over the intracellular and extracellular media; the membrane voltage; and the fast application of pharmacological compounds, such as a variety of ionic or pH indicators, to the intra- and extracellular media...
June 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28651515/statistical-analysis-plan-for-the-adjunctive-corticosteroid-treatment-in-critically-ill-patients-with-septic-shock-adrenal-trial
#2
Laurent Billot, Balasubramanian Venkatesh, John Myburgh, Simon Finfer, Jeremy Cohen, Steve Webb, Colin McArthur, Christopher Joyce, Rinaldo Bellomo, Andrew Rhodes, Anders Perner, Yaseen Arabi, Dorrilyn Rajbhandari, Parisa Glass, Kelly Thompson, Maryam Correa, Meg Harward
BACKGROUND: The Adjunctive Corticosteroid Treatment in Critically Ill Patients with Septic Shock (ADRENAL) trial, a 3800-patient, multicentre, randomised controlled trial, will be the largest study to date of corticosteroid therapy in patients with septic shock. OBJECTIVE: To describe a statistical analysis plan (SAP) and make it public before completion of patient recruitment and data collection. The SAP will be adhered to for the final data analysis of this trial, to avoid analysis bias arising from knowledge of study findings...
June 2017: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/28640269/addendum-the-antibody-aducanumab-reduces-a%C3%AE-plaques-in-alzheimer-s-disease
#3
Jeff Sevigny, Ping Chiao, Thierry Bussière, Paul H Weinreb, Leslie Williams, Marcel Maier, Robert Dunstan, Stephen Salloway, Tianle Chen, Yan Ling, John O'Gorman, Fang Qian, Mahin Arastu, Mingwei Li, Sowmya Chollate, Melanie S Brennan, Omar Quintero-Monzon, Robert H Scannevin, H Moore Arnold, Thomas Engber, Kenneth Rhodes, James Ferrero, Yaming Hang, Alvydas Mikulskis, Jan Grimm, Christoph Hock, Roger M Nitsch, Alfred Sandrock
This corrects the article DOI: 10.1038/nature21361.
June 21, 2017: Nature
https://www.readbyqxmd.com/read/28635948/munc13-1-and-munc18-1-together-prevent-nsf-dependent-de-priming-of-synaptic-vesicles
#4
Enqi He, Keimpe Wierda, Rhode van Westen, Jurjen H Broeke, Ruud F Toonen, L Niels Cornelisse, Matthijs Verhage
Synaptic transmission requires a stable pool of release-ready (primed) vesicles. Here we show that two molecules involved in SNARE-complex assembly, Munc13-1 and Munc18-1, together stabilize release-ready vesicles by preventing de-priming. Replacing neuronal Munc18-1 by a non-neuronal isoform Munc18-2 (Munc18-1/2SWAP) supports activity-dependent priming, but primed vesicles fall back into a non-releasable state (de-prime) within seconds. Munc13-1 deficiency produces a similar defect. Inhibitors of N-ethylmaleimide sensitive factor (NSF), N-ethylmaleimide (NEM) or interfering peptides, prevent de-priming in munc18-1/2SWAP or munc13-1 null synapses, but not in CAPS-1/2 null, another priming-deficient mutant...
June 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28631101/stationary-cycling-exergame-use-among-inactive-children-in-the-family-home-a-randomized-trial
#5
Ryan E Rhodes, Chris M Blanchard, Shannon S D Bredin, Mark R Beauchamp, Ralph Maddison, Darren E R Warburton
Exergames may be one way to increase child physical activity, but long term adherence has seen little research attention. The primary objective of this study was to evaluate the usage of an exergame bike in comparison to a stationary bike in front of a TV across 3-months within a family home environment among children aged 10-14 years old. Seventy-three inactive children were recruited through advertisements and randomized to either the exergame condition (n = 39) or the standard bike condition (n = 34)...
June 19, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28629879/prediction-of-cognition-in-parkinson-s-disease-with-a-clinical-genetic-score-a-longitudinal-analysis-of-nine-cohorts
#6
Ganqiang Liu, Joseph J Locascio, Jean-Christophe Corvol, Brendon Boot, Zhixiang Liao, Kara Page, Daly Franco, Kyle Burke, Iris E Jansen, Ana Trisini-Lipsanopoulos, Sophie Winder-Rhodes, Caroline M Tanner, Anthony E Lang, Shirley Eberly, Alexis Elbaz, Alexis Brice, Graziella Mangone, Bernard Ravina, Ira Shoulson, Florence Cormier-Dequaire, Peter Heutink, Jacobus J van Hilten, Roger A Barker, Caroline H Williams-Gray, Johan Marinus, Clemens R Scherzer
BACKGROUND: Cognitive decline is a debilitating manifestation of disease progression in Parkinson's disease. We aimed to develop a clinical-genetic score to predict global cognitive impairment in patients with the disease. METHODS: In this longitudinal analysis, we built a prediction algorithm for global cognitive impairment (defined as Mini Mental State Examination [MMSE] ≤25) using data from nine cohorts of patients with Parkinson's disease from North America and Europe assessed between 1986 and 2016...
June 16, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28629250/a-comparison-between-the-effects-of-ginger-pyridoxine-vitamin-b6-and-placebo-for-the-treatment-of-the-first-trimester-nausea-and-vomiting-of-pregnancy-nvp
#7
Fatemeh Sharifzadeh, Maryam Kashanian, Jalil Kouhpayehzadeh, Fatemeh Rezaian, Narges Sheikhansari, Nooshin Eshraghi
INTRODUCTION: Nausea and vomiting of pregnancy (NVP) are one of the most common complains of the early pregnancy period and are bothersome for pregnant women. Some prefer to use herbal medicine instead of chemical agents. OBJECTIVE: The purpose of the present study was to compare the effects of ginger, pyridoxine (vitamin B6) and placebo for the treatment of NVP. METHOD: The study was performed as a triple blind clinical trial on pregnant women suffering mild to moderate NVP between 6-16 weeks of pregnancy...
June 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28628191/abiotic-and-biotic-factors-modulate-carrion-fate-and-vertebrate-scavenging-communities
#8
Kelsey L Turner, Erin F Abernethy, L Mike Conner, Olin E Rhodes, James C Beasley
Carrion is a valuable nutrient resource used by a diversity of vertebrates across the globe. However, vertebrate scavenging ecology remains an understudied area of science, especially in regards to how biotic and abiotic factors influence scavenging community composition. Here we elucidate how fundamental biotic and abiotic factors interact to modulate the efficiency and composition of vertebrate scavengers by investigating scavenging dynamics across a large gradient in carcass sizes and habitat types representative of many temperate ecosystems, as well as between two seasons reflecting differences in invertebrate activity...
June 19, 2017: Ecology
https://www.readbyqxmd.com/read/28625375/decline-in-peak-oxygen-consumption-over-time-predicts-death-or-transplantation-in-adults-with-a-fontan-circulation
#9
Jonathan W Cunningham, Ashwin S Nathan, Jonathan Rhodes, Keri Shafer, Michael J Landzberg, Alexander R Opotowsky
Peak oxygen consumption (pVO2) measured by cardiopulmonary exercise test (CPET) predicts mortality in adults with a Fontan circulation. The purpose of this study was to assess the additive prognostic value of change in pVO2 over time. METHODS: We analyzed a cohort of adults (≥18 years old) with a Fontan circulation who underwent at least 2 maximal CPETs separated by 6-30 months at Boston Children's Hospital between 2000 and 2015. Survival analysis was performed to determine whether changes in CPET variables, including pVO2 between consecutive tests, were associated with subsequent clinical events...
July 2017: American Heart Journal
https://www.readbyqxmd.com/read/28625196/the-effectiveness-of-enhanced-cognitive-behavioural-therapy-cbt-e-a-naturalistic-study-within-an-out-patient-eating-disorder-service
#10
Rachel Signorini, Jeanie Sheffield, Natalie Rhodes, Carmel Fleming, Warren Ward
BACKGROUND: The effectiveness of enhanced cognitive behavioural Therapy (CBT-E) for adults with a range of eating disorder presentations within routine clinical settings has been examined in only two known published studies, neither of which included a follow-up assessment period. AIM: The current study aimed to evaluate the effectiveness of CBT-E within an out-patient eating disorder service in Brisbane, Queensland, Australia, and incorporated a follow-up assessment period of approximately 20 weeks post-treatment...
June 19, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28624645/cingulo-opercular-activity-affects-incidental-memory-encoding-for-speech-in-noise
#11
Kenneth I Vaden, Susan Teubner-Rhodes, Jayne B Ahlstrom, Judy R Dubno, Mark A Eckert
Correctly understood speech in difficult listening conditions is often difficult to remember. A long-standing hypothesis for this observation is that the engagement of cognitive resources to aid speech understanding can limit resources available for memory encoding. This hypothesis is consistent with evidence that speech presented in difficult conditions typically elicits greater activity throughout cingulo-opercular regions of frontal cortex that are proposed to optimize task performance through adaptive control of behavior and tonic attention...
June 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/28624389/plasma-proteome-analysis-in-patients-with-pulmonary-arterial-hypertension-an-observational-cohort-study
#12
Christopher J Rhodes, John Wharton, Pavandeep Ghataorhe, Geoffrey Watson, Barbara Girerd, Luke S Howard, J Simon R Gibbs, Robin Condliffe, Charles A Elliot, David G Kiely, Gerald Simonneau, David Montani, Olivier Sitbon, Henning Gall, Ralph T Schermuly, H Ardeschir Ghofrani, Allan Lawrie, Marc Humbert, Martin R Wilkins
BACKGROUND: Idiopathic and heritable pulmonary arterial hypertension form a rare but molecularly heterogeneous disease group. We aimed to measure and validate differences in plasma concentrations of proteins that are associated with survival in patients with idiopathic or heritable pulmonary arterial hypertension to improve risk stratification. METHODS: In this observational cohort study, we enrolled patients with idiopathic or heritable pulmonary arterial hypertension from London (UK; cohorts 1 and 2), Giessen (Germany; cohort 3), and Paris (France; cohort 4)...
June 14, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28622614/desirable-difficulties-during-the-development-of-active-inquiry-skills
#13
George Kachergis, Marjorie Rhodes, Todd Gureckis
This study explores developmental changes in the ability to ask informative questions, hypothesizing a link between the ability to update beliefs in light of evidence and the ability to ask informative questions. Five- to ten-year-old children played an iPad game asking them to identify a hidden insect. Learners could either ask about individual insects, or make a series of feature queries (e.g., "Does the hidden insect have antenna?") that could more efficiently narrow the hypothesis space. Critically, the task display either helped children integrate evidence with the hypothesis space or required them to perform this operation themselves...
June 13, 2017: Cognition
https://www.readbyqxmd.com/read/28622239/the-whole-is-greater-than-the-sum-of-its-parts
#14
Jonathan Rhodes, Louise Sinclair, Irene Puddu, Aryelly Rodriguez, Peter Andrews
No abstract text is available yet for this article.
July 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28622106/parent-support-for-children-s-physical-activity-a-qualitative-investigation-of-barriers-and-strategies
#15
Rebecca Bassett-Gunter, Ryan Rhodes, Shane Sweet, Lauren Tristani, Yasaman Soltani
PURPOSE: Parents play an important role in supporting children's physical activity (PA) behavior. Parent PA support is a behavior unto itself that has been examined within the framework of an adapted theory of planned behavior (TPB). The primary purpose of this research was to identify key barriers to parent PA support to understand perceptions of control in relation to parent PA support. The second purpose of this research was to identify potential strategies to enhance parent PA support via enhanced perceived behavioral control...
June 16, 2017: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/28622096/practical-considerations-for-managing-helicobacter-pylori-in-college-health
#16
Laura A Rhodes
OBJECTIVE: To perform a literature review assessing the management of H. pylori management in international college students. METHODS: A comprehensive literature search was conducted using the following key words: Helicobacter pylori, H pylori, student, college student, college health, treatment, guidelines, resistance, and antibiotic resistant. RESULTS: No additional literature was found that directly addresses the treatment of H. pylori infection in international college students...
June 16, 2017: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/28622019/patient-perceptions-of-illness-identity-in-cancer-clinical-trial-decision-making
#17
Angela L Palmer-Wackerly, Phokeng M Dailey, Jessica L Krok-Schoen, Nancy D Rhodes, Janice L Krieger
When patients are diagnosed with cancer, they begin to negotiate their illness identity in relation to their past and future selves, their relationships, and their group memberships. Thus, how patients view their cancer in relation to their other identities may affect how and why they make particular decisions about treatment options. Using the Communication Theory of Identity (CTI), the current study explores: (1) how and why illness identity is framed across identity layers in relation to one particular cancer treatment: participation in a cancer clinical trial (CT); and (2) how and why patients experience identity conflicts while making their treatment decisions...
June 16, 2017: Health Communication
https://www.readbyqxmd.com/read/28619995/codependence-of-bone-morphogenetic-protein-receptor-2-and-transforming-growth-factor-%C3%AE-in-elastic-fiber-assembly-and-its-perturbation-in-pulmonary-arterial-hypertension
#18
Nancy F Tojais, Aiqin Cao, Ying-Ju Lai, Lingli Wang, Pin-I Chen, Miguel A Alejandre Alcazar, Vinicio de Jesus Perez, Rachel K Hopper, Christopher J Rhodes, Matthew A Bill, Lynn Y Sakai, Marlene Rabinovitch
OBJECTIVE: We determined in patients with pulmonary arterial (PA) hypertension (PAH) whether in addition to increased production of elastase by PA smooth muscle cells previously reported, PA elastic fibers are susceptible to degradation because of their abnormal assembly. APPROACH AND RESULTS: Fibrillin-1 and elastin are the major components of elastic fibers, and fibrillin-1 binds bone morphogenetic proteins (BMPs) and the large latent complex of transforming growth factor-β1 (TGFβ1)...
June 15, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28617125/-emergency-nursing-is-the-best-job-you-ll-ever-have
#19
Layla Haidrani
What is your job? I am a clinical development specialist at Hasbro Children's Hospital, the paediatric division of Rhode Island Hospital in Providence, US. I educate and mentor new graduate nurses from the paediatric emergency department (ED) and inpatient areas.
June 15, 2017: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/28616660/arenavirus-dynamics-in-experimentally-and-naturally-infected-rodents
#20
Joachim Mariën, Benny Borremans, Sophie Gryseels, Bram Vanden Broecke, Beate Becker-Ziaja, Rhodes Makundi, Apia Massawe, Jonas Reijniers, Herwig Leirs
Infectious diseases of wildlife are typically studied using data on antibody and pathogen levels. In order to interpret these data, it is necessary to know the course of antibodies and pathogen levels after infection. Such data are typically collected using experimental infection studies in which host individuals are inoculated in the laboratory and sampled over an extended period, but because laboratory conditions are controlled and much less variable than natural conditions, the immune response and pathogen dynamics may differ...
June 14, 2017: EcoHealth
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