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https://www.readbyqxmd.com/read/28804877/validation-of-a-geriatric-trauma-prognosis-calculator-a-p-a-l-li-a-t-e-consortium-study
#1
Allyson C Cook, Bellal Joseph, M Jane Mohler, Kenji Inaba, Brandon R Bruns, Paul A Nakonezny, Jeff D Kerby, Karen J Brasel, Steven E Wolf, Joseph Cuschieri, M Elizabeth Paulk, Ramona L Rhodes, Scott C Brakenridge, A Peter Ekeh, Herb A Phelan
BACKGROUND/OBJECTIVES: The P.A.L.Li.A.T.E. (prognostic assessment of life and limitations after trauma in the elderly) consortium has previously created a prognosis calculator for mortality after geriatric injury based on age, injury severity, and transfusion requirement called the geriatric trauma outcome score (GTOS). Here, we sought to create and validate a prognosis calculator called the geriatric trauma outcome score ii (GTOS II) estimating probability of unfavorable discharge. DESIGN: Retrospective cohort...
August 14, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28803934/doses-durations-and-gender-predict-vancomycin-induced-kidney-injury-in-pre-clinical-studies
#2
J Nicholas O'Donnell, Nathaniel J Rhodes, Cristina M Miglis, Lejla Catovic, Jiajun Liu, Cameron Cluff, Gwen Pais, Sean Avedissian, Medha Joshi, Brooke Griffin, Walter Prozialeck, Anil Gulati, Thomas P Lodise, Marc H Scheetz
Background While vancomycin's exposure-dependent efficacy thresholds have been probed, less is known regarding acute kidney injury (AKI) thresholds for vancomycin. Sensitive urinary biomarkers such as Kidney injury molecule 1 (KIM-1) have shown high sensitivity and specificity for vancomycin-associated AKI. We sought to determine if dose-response curves existed with urinary KIM-1. Secondarily, we sought to evaluate the impact of therapy duration and gender status on observed relationships. Methods A systematic review was conducted via PubMed/MEDLINE...
August 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28803216/3d-2d-registration-with-superabundant-vessel-reconstruction-for-cardiac-resynchronization-therapy
#3
Daniel Toth, Maria Panayiotou, Alexander Brost, Jonathan M Behar, Christopher A Rinaldi, Kawal S Rhode, Peter Mountney
A key component of image guided interventions is the registration of preoperative and intraoperative images. Classical registration approaches rely on cross-modality information; however, in modalities such as MRI and X-ray there may not be sufficient cross-modality information. This paper proposes a fundamentally different registration approach which uses adjacent anatomical structures with superabundant vessel reconstruction and dynamic outlier rejection. In the targeted clinical scenario of cardiac resynchronization therapy (CRT) delivery, preoperative, non contrast-enhanced, MRI is registered to intraoperative, contrasted X-ray fluoroscopy...
August 5, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28792676/the-messenger-matters-pollinator-functional-group-influences-mating-system-dynamics
#4
Jennifer J Weber
The incredible diversity of plant mating systems has fuelled research in evolutionary biology for over a century. Currently, there is broad concern about the impact of rapidly changing pollinator communities on plant populations. Very few studies, however, examine patterns and mechanisms associated with multiple paternity from cross-pollen loads. Often, foraging pollinators collect a mixed pollen load that may result in the deposition of pollen from different sires to receptive stigmas. Coincident deposition of self- and cross-pollen leads to interesting mating system dynamics and has been investigated in numerous species...
August 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28792079/mentoring-relationship-quality-and-maltreated-children-s-coping
#5
Ashley A Chesmore, Lindsey M Weiler, Heather N Taussig
Coping strategies are believed to protect against the harmful effects of maltreatment on children's psychosocial outcomes. Caregivers are thought to be critical in helping children develop adaptive coping strategies, yet many maltreated children have poor and/or insecure relationships with their parents. A quality relationship with a caring, non-parental adult (e.g., a mentor), however, may be one strategy to promote healthy coping among maltreated children. Children (N = 154) in this study participated in a mentoring and skill-based program for maltreated preadolescents placed in foster care...
August 9, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/28791777/mutations-in-the-katnb1-gene-cause-left-right-asymmetry-and-heart-defects
#6
M B Furtado, D J Merriner, S Berger, D Rhodes, D Jamsai, M K O'Bryan
BACKGROUND: The microtubule-severing protein complex katanin is composed two subunits, the ATPase subunit, KATNA1, and the non-catalytic regulatory subunit, KATNB1. Recently, the Katnb1 gene has been linked to infertility, regulation of centriole and cilia formation in fish and mammals, as well as neocortical brain development. KATNB1 protein is expressed in germ cells in humans and mouse, mitotic/meiotic spindles and cilia, although the full expression pattern of the Katnb1 gene has not been described...
August 9, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28777685/sexual-minority-disparities-in-substance-use-willingness-among-youth
#7
Kristi E Gamarel, Ethan H Mereish, Suzanne M Colby, Nancy P Barnett, Kerri Hayes, Kristina M Jackson
BACKGROUND: Disparities in substance use have been observed in sexual minority youth, but less is known about willingness to use substances, an important precursor to actual use. OBJECTIVE: The goal of this study was to examine willingness to use cigarettes, alcohol, and marijuana among sexual minority youth compared to their non-sexual minority counterparts using both cross-sectional and longitudinal data. METHODS: The present study drew on two waves (Times 1 and 2; 6 months apart) of data collected during high school as part of a prospective study of substance use initiation and progression in Rhode Island...
August 4, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28775301/high-diversity-and-unique-composition-of-gut-microbiomes-in-pygmy-kogia-breviceps-and-dwarf-k-sima-sperm-whales
#8
Patrick M Erwin, Ryan G Rhodes, Kevin B Kiser, Tiffany F Keenan-Bateman, William A McLellan, D Ann Pabst
Mammals host diverse bacterial and archaeal symbiont communities (i.e. microbiomes) that play important roles in digestive and immune system functioning, yet cetacean microbiomes remain largely unexplored, in part due to sample collection difficulties. Here, fecal samples from stranded pygmy (Kogia breviceps) and dwarf (K. sima) sperm whales were used to characterize the gut microbiomes of two closely-related species with similar diets. 16S rRNA gene sequencing revealed diverse microbial communities in kogiid whales dominated by Firmicutes and Bacteroidetes...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28774975/genome-sequence-of-human-papillomavirus-type-20-strain-hpv-20-lancaster-2015
#9
Kate V Atkinson, Lisa A Bishop, Glenn Rhodes, Nicolas Salez, Neil R McEwan, Matthew J Hegarty, Julie Robey, Nicola Harding, Simon Wetherell, Robert M Lauder, Roger W Pickup, Mark Wilkinson, Derek Gatherer
The genome sequence of human papillomavirus type 20 (HPV-20; family Papillomaviridae, genus Betapapillomavirus, species Betapapillomavirus 1, type 20) was assembled by deep sequencing from nasopharyngeal swabs. The assembled genome is 0.37% divergent over its full length from the single complete genome of HPV-20 in GenBank (U31778). We named the strain HPV-20/Lancaster/2015.
August 3, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28774325/what-is-the-impact-of-the-fluid-challenge-technique-on-diagnosis-of-fluid-responsiveness-a-systematic-review-and-meta-analysis
#10
Laura Toscani, Hollmann D Aya, Dimitra Antonakaki, Davide Bastoni, Ximena Watson, Nish Arulkumaran, Andrew Rhodes, Maurizio Cecconi
BACKGROUND: The fluid challenge is considered the gold standard for diagnosis of fluid responsiveness. The objective of this study was to describe the fluid challenge techniques reported in fluid responsiveness studies and to assess the difference in the proportion of 'responders,' (PR) depending on the type of fluid, volume, duration of infusion and timing of assessment. METHODS: Searches of MEDLINE and Embase were performed for studies using the fluid challenge as a test of cardiac preload with a description of the technique, a reported definition of fluid responsiveness and PR...
August 4, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28770090/relational-containment-exploring-the-effect-of-family-based-treatment-for-anorexia-on-familial-relationships
#11
Andrew Wallis, Paul Rhodes, Lisa Dawson, Jane Miskovic-Wheatley, Sloane Madden, Stephen Touyz
BACKGROUND: The aim of this research was to investigate the process of familial relationship change for adolescents with anorexia nervosa and their parents, who participated in Family-Based Treatment (FBT). METHOD: A Constructionist grounded theory design was employed with purposive sampling. Sixteen young people between 12 and 18 years with a good outcome in FBT and twenty-eight of their parents participated. Young people and their parents took part in separate interviews at the end of treatment...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/28768644/age-and-sex-disparities-in-discharge-statin-prescribing-in-the-stroke-belt-evidence-from-the-reasons-for-geographic-and-racial-differences-in-stroke-study
#12
Karen C Albright, Virginia J Howard, George Howard, Paul Muntner, Vera Bittner, Monika M Safford, Amelia K Boehme, J David Rhodes, T Mark Beasley, Suzanne E Judd, Leslie A McClure, Nita Limdi, Justin Blackburn
BACKGROUND: Stroke is a costly and debilitating disease that disproportionately affects blacks. Despite the efficacy of statins, evidence suggests racial disparities may exist in statin prescribing. METHODS AND RESULTS: We analyzed discharge medications for participants hospitalized for an ischemic stroke during follow-up of the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study. Medications on admission and discharge were abstracted from medical records...
August 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28767517/accuracy-of-self-reported-weight-in-hispanic-latino-adults-of-the-hispanic-community-health-study-study-of-latinos-hchs-sol
#13
Lindsay Fernández-Rhodes, Whitney R Robinson, Daniela Sotres-Alvarez, Nora Franceschini, Sheila F Castañeda, Christina Buelna, Ashley Moncrieft, Maria Llabre, Martha L Daviglus, Qibin Qi, Anita Agarwal, Carmen R Isasi, Paul Smokowski, Penny Gordon-Larsen, Kari E North
BACKGROUND: Previous United States (U.S.) population-based studies have found that body weight may be underestimated when self-reported. However, this research may not apply to all U.S. Hispanics/Latinos, many of whom are immigrants with distinct cultural orientations to ideal body size. We assessed the data quality and accuracy of self-reported weight in a diverse, community-based, U.S. sample of primarily foreign-born Hispanic/Latino adults. METHODS: Using baseline data (2008-2011) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we described the difference between contemporaneous self-reported and measured current body weight (n=16,119) and used multivariate adjusted models to establish whether the observed trends in misreporting in potential predictors of inaccuracy persisted after adjustment for other predictors...
July 31, 2017: Epidemiology
https://www.readbyqxmd.com/read/28767094/depressive-symptoms-and-length-of-u-s-residency-are-associated-with-obesity-among-low-income-latina-mothers-a-cross-sectional-analysis
#14
Ana Cristina Lindsay, Mary L Greaney, Sherrie F Wallington, Julie A Wright, Anne T Hunt
Latinos are the largest minority population group in the United States (U.S.), and low-income Latina women are at elevated risk of depression and obesity. Thus, the prevention of these two problems is a pressing public health concern in this population. Both depressive symptoms and obesity are modifiable factors that can be addressed by culturally relevant interventions. However, the association between depressive symptoms and obesity in Latina immigrant women is not well understood. Therefore, this cross-sectional study examined the association between depressive symptoms and obesity among Latina women of childbearing age (15-44)...
August 2, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28767092/molecular-identification-of-gambierdiscus-and-fukuyoa-dinophyceae-from-environmental-samples
#15
Kirsty F Smith, Laura Biessy, Phoebe A Argyle, Tom Trnski, Tuikolongahau Halafihi, Lesley L Rhodes
Ciguatera Fish Poisoning (CFP) is increasing across the Pacific and the distribution of the causative dinoflagellates appears to be expanding. Subtle differences in thecal plate morphology are used to distinguish dinoflagellate species, which are difficult to determine using light microscopy. For these reasons we sought to develop a Quantitative PCR assay that would detect all species from both Gambierdiscus and Fukuyoa genera in order to rapidly screen environmental samples for potentially toxic species. Additionally, a specific assay for F...
August 2, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28766026/rectal-douching-among-men-who-have-sex-with-men-in-paris-implications-for-hiv-sti-risk-behaviors-and-rectal-microbicide-development
#16
H Rhodes Hambrick, Su Hyun Park, William C Goedel, Jace G Morganstein, Noah T Kreski, Ofole Mgbako, Dustin T Duncan
Rectal douching is a common but potentially risky practice among MSM; MSM who douche may be ideal candidates for rectal microbicides as HIV prevention. Herein we explored rectal douching and its association with condomless receptive anal intercourse (CRAI), group sex, rates of HIV and other STIs, and likelihood to use rectal microbicide gels. We recruited a sample of 580 MSM from a geosocial-networking smartphone application in Paris, France in 2016. Regression models estimated adjusted risk ratios (aRRs) for associations between rectal douche use and (1) engagement in CRAI, (2) group sex, (3) self-reported HIV and STI diagnoses, and (4) likelihood to use rectal microbicide gels for HIV prevention...
August 1, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28764964/motor-deficits-impaired-response-inhibition-and-blunted-response-to-methylphenidate-following-neonatal-exposure-to-decabromodiphenyl-ether
#17
Vincent P Markowski, Patrick Miller-Rhodes, Randy Cheung, Calla Goeke, Vincent Pecoraro, Gideon Cohen, Deena J Small
Decabromodiphenyl ether (decaBDE) is an applied brominated flame retardant that is widely-used in electronic equipment. After decades of use, decaBDE and other members of its polybrominated diphenyl ether class have become globally-distributed environmental contaminants that can be measured in the atmosphere, water bodies, wildlife, food staples and human breastmilk. Although it has been banned in Europe and voluntarily withdrawn from the U.S. market, it is still used in Asian countries. Evidence from epidemiological and animal studies indicate that decaBDE exposure targets brain development and produces behavioral impairments...
July 29, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28762890/the-latency-of-the-light-response-is-modulated-by-the-phosphorylation-state-of-drosophila-trp-at-a-specific-site
#18
Ben Katz, Olaf Voolstra, Hanan Tzadok, Bushra Yasin, Elisheva Rhodes-Modrov, Jonas-Peter Bartels, Lisa Strauch, Armin Huber, Baruch Minke
Drosophila photoreceptors respond to oscillating light of high frequency (∼100 Hz), while increasing the oscillating light intensity raises the maximally detected frequency. Recently, we reported that dephosphorylation of the light-activated TRP ion channel at S936 is a fast, graded, light-, and Ca(2+)-dependent process. We further found that this process affects the detection limit of high frequency oscillating light. Accordingly, transgenic Drosophila, which do not undergo phosphorylation at the S936-TRP site (trp(S936A)), revealed a short time-interval before following the high stimulus frequency (oscillation-lock response) in both dark- and light-adapted flies...
August 1, 2017: Channels
https://www.readbyqxmd.com/read/28760175/a-randomized-control-intervention-investigating-the-effects-of-acute-exercise-on-emotional-regulation
#19
Meghan K Edwards, Ryan E Rhodes, Paul D Loprinzi
OBJECTIVES: Exercise may help to cope with hectic or demanding events after a stressful situation occurs. Limited research has evaluated whether exercise, prior to a stressor, helps to facilitate subsequent emotional regulation. This pilot study addresses this novel paradigm. We employed a randomized controlled trial evaluating the effects of acute exercise on emotional regulation. METHODS: Participants were randomly assigned to stretch (control group, N = 10), walk (N = 9), or jog (N = 8) for 15-minutes, after which they were exposed to a film clip intended to elicit a negative emotional response...
September 1, 2017: American Journal of Health Behavior
https://www.readbyqxmd.com/read/28756133/effect-of-nurse-led-randomised-control-trials-on-cardiovascular-risk-factors-and-hba1c-in-diabetes-patients-a-meta-analysis
#20
REVIEW
Barbara Daly, Catherine Jia Lin Tian, Robert Keith Rhodes Scragg
A systematic review and meta-analysis identified 42 randomised control trials comparing a nurse-led intervention with 'usual care' to quantify their effect on glycated haemoglobin (HbA1c) and major cardiovascular risk factors in diabetes patients. All relevant databases were systematically searched for publications to February 2016: MEDLINE, Cochrane Central Register of Controlled Trials, EMBASE and Cumulative Index to Nursing & Allied Health Literature (CINAHL). The 42 trials recruited 9955 diabetes patients (5022 randomised to intervention and 4933 to 'usual care')...
July 14, 2017: Diabetes Research and Clinical Practice
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