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ischemic reperfusion injury

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https://www.readbyqxmd.com/read/29040168/failure-of-isoflurane-cardiac-preconditioning-in-obese-type-2-diabetic-mice-involves-aberrant-regulation-of-microrna-21-endothelial-nitric-oxide-synthase-and-mitochondrial-complex-i
#1
Zhi-Dong Ge, Yingchuan Li, Shigang Qiao, Xiaowen Bai, David C Warltier, Judy R Kersten, Zeljko J Bosnjak, Mingyu Liang
BACKGROUND: Diabetes impairs the cardioprotective effect of volatile anesthetics, yet the mechanisms are still murky. We examined the regulatory effect of isoflurane on microRNA-21, endothelial nitric-oxide synthase, and mitochondrial respiratory complex I in type II diabetic mice. METHODS: Myocardial ischemia/reperfusion injury was produced in obese type 2 diabetic (db/db) and C57BL/6 control mice ex vivo in the presence or absence of isoflurane administered before ischemia...
October 17, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29035876/hydrogen-gas-attenuates-myocardial-ischemia-reperfusion-injury-independent-of-postconditioning-in-rats-by-attenuating-endoplasmic-reticulum-stress-induced-autophagy
#2
Yunan Gao, Hongxiao Yang, Jing Chi, Qiannan Xu, Luqi Zhao, Weijia Yang, Weifan Liu, Wei Yang
BACKGROUND/AIMS: To study the effect of inhaling hydrogen gas on myocardial ischemic/reperfusion(I/R) injury in rats. METHODS: Seventy male Wistar albino rats were divided into five groups at random as the sham group (Sham). The I/R group (I/R), The ischemic postconditioning group (IPo), The I/R plus hydrogen group (IH2) and the ischemic postconditioning plus hydrogen group (IPoH2). The Sham group was without coronary occlusion. In I/R group, Ischemic/reperfusion injury was induced by coronary occlusion for 1 hour...
October 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29031902/chrysophanol-inhibits-endoplasmic-reticulum-stress-in-cerebral-ischemia-and-reperfusion-mice
#3
Yongmei Zhao, Yalan Fang, Haiping Zhao, Jincheng Li, Yunxia Duan, Wenjuan Shi, Yuyou Huang, Li Gao, Yumin Luo
Endoplasmic reticulum (ER) stress plays a critical role in mediating ischemia/reperfusion (I/R) damage in the brain. Our previous study showed that Chrysophanol (CHR) alleviated cerebral ischemic injury in mice and nuclear factor-κB (NF-κB) involved in its neuroprotective effect, but the precise mechanism remains not fully understood. The present study investigated the effect of CHR treatment on I/R-induced ER stress. Mice were subjected to middle cerebral artery occlusion (MCAO) for 45min and received either vehicle or CHR (0...
October 11, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29027966/myocardial-expression-of-macrophage-migration-inhibitory-factor-in-patients-with-heart-failure
#4
Julia Pohl, Ulrike B Hendgen-Cotta, Pia Stock, Peter Luedike, Hideo Andreas Baba, Markus Kamler, Tienush Rassaf
Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory protein and contributes to several different inflammatory and ischemic/hypoxic diseases. MIF was shown to be cardioprotective in experimental myocardial ischemia/reperfusion injury and its expression is regulated by the transcription factor hypoxia-inducible factor (HIF)-1α. We here report on MIF expression in the failing human heart and assess myocardial MIF in different types of cardiomyopathy. Myocardial tissue samples from n = 30 patients were analyzed by quantitative Real-Time PCR...
October 13, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29026009/inactivated-lactobacillus-promotes-the-protection-against-myocardial-ischemia-reperfusion-injury-through%C3%A2-nf-%C3%AE%C2%BA-b-pathway
#5
Ni Wang, Genhong Song, Yang Yang, Weiwei Yuan, Ming Qi
Objectives: Although restoration of blood flow to an ischemic organ is essential to prevent irreversible cellular injury, reperfusion may augment tissue injury in excess of that produced by ischemia alone. So this experiment was designed to study the protective effects and mechanism of inactivated lactobacillus (Lac) on myocardial ischemia reperfusion injury (MIRI). Methods: MIRI rat models were established by ligation of left anterior descending coronary artery for about 30 min and then, reperfusion for 120 min and divided into control group, model group and Lac (10(6), 10(7) and 10(8)cfu/kg) groups...
October 12, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29024000/myeloid-notch1-deficiency-activates-rhoa-rock-pathway-and-aggravates-hepatocellular-damage-in-mouse-ischemic-livers
#6
Ling Lu, Shi Yue, Longfeng Jiang, Changyong Li, Qiang Zhu, Michael Ke, Hao Lu, Xuehao Wang, Ronald W Busuttil, Qi-Long Ying, Jerzy W Kupiec-Weglinski, Bibo Ke
Notch signaling plays an emerging role in the regulation of immune cell development and function during inflammatory response. Activation of the ras homolog gene family, member A (RhoA)/Rho-associated protein kinase (ROCK) pathway promotes leukocyte accumulation in tissue injury. However, it remains unknown whether Notch signaling regulates RhoA/ROCK-mediated immune responses in liver ischemia and reperfusion injury (IRI). This study investigated intracellular signaling pathways regulated by Notch receptors in the IR-stressed liver and in vitro...
October 12, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29023177/is-remote-ischemic-conditioning-of-benefit-to-patients-undergoing-kidney-transplantation
#7
Wisit Cheungpasitporn, Nadeen J Khoury, Charat Thongprayoon, Iasmina M Craici
Renal ischemia-reperfusion injury (IRI), an inevitable event during kidney transplantation procedure, can result in delayed graft function or even primary nonfunction. In addition to strategies to limit IRI such as advancements in organ allocation systems and preservation of organs, and reduction in cold and warm ischemia time, remote ischemic conditioning (RIC) has attracted much attention in recent years. With promising findings and data suggesting a potential benefit of RIC in animal kidney transplantation models, a few clinical trials have investigated the use of RIC in human kidney transplantation...
October 12, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29022896/microrna-378-protects-against-intestinal-ischemia-reperfusion-injury-via-a-mechanism-involving-the-inhibition-of-intestinal-mucosal-cell-apoptosis
#8
Yunsheng Li, Shihong Wen, Xi Yao, Weifeng Liu, Jiantong Shen, Wentao Deng, Jing Tang, Cai Li, Kexuan Liu
Intestinal ischemia/reperfusion (I/R) injury remains a major clinical event and contributes to high morbidity and mortality rates, but the underlying mechanisms remain elusive. Recent studies have demonstrated that microRNAs (miRNAs) have important roles in organ I/R injury, but the changes and potential roles of miRNAs in intestinal I/R-induced intestinal injury are unclear. This study was designed to analyze the miRNA expression profiles in intestinal mucosa after I/R injury and to explore the role of target miRNA during this process...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29022576/xueshuantong-injection-lyophilized-combined-with-salvianolate-lyophilized-injection-protects-against-focal-cerebral-ischemia-reperfusion-injury-in-rats-through-attenuation-of-oxidative-stress
#9
Fu-Jiang Wang, Shao-Xia Wang, Li-Juan Chai, Yue Zhang, Hong Guo, Li-Min Hu
Salvianolate lyophilized injection (SLI) and Xueshuantong injection (lyophilized) (XST) are two herbal standardized preparations that have been widely used in China for the treatment of acute cerebral infarction. In this study, we investigated the neuroprotective effects of SLI combined with XST in a rat model of middle cerebral artery occlusion-reperfusion (MCAO/R). Wistar rats were subjected to 1.5 h of MCAO followed by reperfusion for 3 h, then were treated with SLI or XST alone, or with their combinations via tail vein injection daily for 3 d...
October 12, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29021225/atp-induces-pad4-in-renal-proximal-tubule-cells-via-p2x7-receptor-activation-to-exacerbate-ischemic-aki
#10
May M Rabadi, Mihwa Kim, Hongmei Li, Sang Jun Han, Yewoon Choi, Vivette Denise D'Agati, H Thomas Lee
We previously demonstrated that renal tubular peptidylarginine deiminase-4 (PAD4) is induced after ischemia reperfusion (IR) injury and this induction of PAD4 exacerbates ischemic acute kidney injury (AKI) by promoting renal tubular inflammation and neutrophil infiltration. However, the mechanisms of renal tubular PAD4 induction after IR remain unknown. Here, we tested the hypothesis that ATP, a pro-inflammatory danger associated molecular pattern (DAMP) ligand released from necrotic cells after IR injury, induces renal tubular PAD4 and exacerbates ischemic AKI via P2 purinergic receptor activation...
October 11, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29019561/atorvastatin-can-prevent-hepatic-remote-reperfusion-injury
#11
Carlos Henrique Marques Dos Santos, Doroty Mesquita Dourado, Baldomero Antonio Kato da Silva, Henrique Budib Dorsa Pontes, Euler de Azevedo-Neto, Giovanna Serra da Cruz Vendas, Ian de Oliveira Chaves, João Victor Cunha Miranda
BACKGROUND: Some studies have shown that statins have a promising effect on protection against reperfusion injury. AIM: To evaluate the ability of ischemic postconditioning, statins and both associated to prevent or minimize reperfusion injury in the liver of rats subjected to ischemia and reperfusion by abdominal aorta clamping. METHOD: Were used 41 Wistar rats, which were distributed into five groups: ischemia and reperfusion (I/R), ischemic postcondictioning (IPC), postconditioning + statin (IPC+S), statin (S) and Sham...
July 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/29018188/cardioprotection-induced-in-a-mouse-model-of-neuropathic-pain-via-anterior-nucleus-of-paraventricular-thalamus
#12
Yi-Fen Cheng, Ya-Ting Chang, Wei-Hsin Chen, Hsi-Chien Shih, Yen-Hui Chen, Bai-Chuang Shyu, Chien-Chang Chen
Myocardial infarction is the leading cause of death worldwide. Restoration of blood flow rescues myocardium but also causes ischemia-reperfusion injury. Here, we show that in a mouse model of chronic neuropathic pain, ischemia-reperfusion injury following myocardial infarction is reduced, and this cardioprotection is induced via an anterior nucleus of paraventricular thalamus (PVA)-dependent parasympathetic pathway. Pharmacological inhibition of extracellular signal-regulated kinase activation in the PVA abolishes neuropathic pain-induced cardioprotection, whereas activation of PVA neurons pharmacologically, or optogenetic stimulation, is sufficient to induce cardioprotection...
October 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/29017857/administration-of-5-methoxyindole-2-carboxylic-acid-that-potentially-targets-mitochondrial-dihydrolipoamide-dehydrogenase-confers-cerebral-preconditioning-against-ischemic-stroke-injury
#13
Jinzi Wu, Rongrong Li, Wenjun Li, Ming Ren, Nopporn Thangthaeng, Nathalie Sumien, Ran Liu, Shaohua Yang, James W Simpkins, Michael J Forster, Liang-Jun Yan
The objective of this study was to investigate a possible role of mitochondrial dihydrolipoamide dehydrogenase (DLDH) as a chemical preconditioning target for neuroprotection against ischemic injury. We used 5-methoxyindole-2-carboxylic acid (MICA), a reportedly reversible DLDH inhibitor, as the preconditioning agent and administered MICA to rats mainly via dietary intake. Upon completion of 4 week's MICA treatment, rats underwent 1h transient ischemia and 24h reperfusion followed by tissue collection. Our results show that MICA protected the brain against ischemic stroke injury as the infarction volume of the brain from the MICA-treated group was significantly smaller than that from the control group...
October 7, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29017492/electroacupuncture-ameliorating-post-stroke-cognitive-impairments-via-inhibition-of-peri-infarct-astroglial-and-microglial-macrophage-p2-purinoceptors-mediated-neuroinflammation-and-hyperplasia
#14
Jia Huang, Xiaofang You, Weilin Liu, Changming Song, Xiaomin Lin, Xiufeng Zhang, Jing Tao, Lidian Chen
BACKGROUND: During ischemic stroke (IS), adenosine 5'-triphosphate (ATP) is released from damaged nerve cells of the infract core region to the extracellular space, invoking peri-infarct glial cellular P2 purinoceptors singling, and causing pro-inflammatory cytokine secretion, which is likely to initiate or aggravate motor and cognitive impairment. It has been proved that electroacupuncture (EA) is an effective and safe strategy used in anti-inflammation. However, EA for the role of purine receptors in the central nervous system has not yet been reported...
October 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29016740/a-novel-fibroblast-growth-factor-1-ligand-with-reduced-heparin-binding-protects-the-heart-against-ischemia-reperfusion-injury-in-the-presence-of-heparin-co-administration
#15
Chahua Huang, Yang Liu, Andrew Beenken, Lin Jiang, Xiang Gao, Zhifeng Huang, Anna Hsu, Garrett J Gross, Yi-Gang Wang, Moosa Mohammadi, Jo El J Schultz
Aims: Fibroblast growth factor 1 (FGF1), a heparin/heparan sulfate-binding growth factor, is a potent cardioprotective agent against myocardial infarction (MI). The impact of heparin, the standard of care for MI patients entering the emergency room, on cardioprotective effects of FGF1 is unknown, however. Methods and results: To address this, a rat model of MI was employed to compare cardioprotective potentials (lower infarct size and improve post-ischemic function) of native FGF1 and an engineered FGF1 (FGF1ΔHBS) with reduced heparin-binding affinity when given at the onset of reperfusion in the absence or presence of heparin...
September 7, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29016703/%C3%AE-arrestin-2-mediates-cardiac-ischemia-reperfusion-injury-via-inhibiting-gpcr-independent-cell-survival-signalling
#16
Yimei Wang, Li Jin, Ying Song, Mao Zhang, Dan Shan, Yuli Liu, Meng Fang, Fengxiang Lv, Rui-Ping Xiao, Yan Zhang
Aims: Ischemic heart disease is a leading cause of morbidity and mortality worldwide. Although timely restoration of coronary blood flow (reperfusion) is the most effective therapeutics of myocardial infarction, reperfusion causes further cardiac damage, i.e. ischemia-reperfusion (I/R) injury. β-arrestins (Arrbs) have been traditionally defined as negative regulators of G protein-coupled receptor (GPCR) signalling, but recent studies have shown that they are essential for G protein-independent, GPCR-mediated biased signalling...
August 4, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28993251/hypoxia-ischemia-modifies-postsynaptic-glun2b-containing-nmda-receptor-complexes-in-the-neonatal-mouse-brain
#17
Fuxin Lu, Guo Shao, Yongqiang Wang, Shenheng Guan, Alma L Burlingame, Xuemei Liu, Xiao Liang, Renatta Knox, Donna M Ferriero, Xiangning Jiang
The N-methyl-d-aspartate-type glutamate receptor (NMDAR)-associated multiprotein complexes are indispensable for synaptic plasticity and cognitive functions. While purification and proteomic analyses of these signaling complexes have been performed in adult rodent and human brain, much less is known about the protein composition of NMDAR complexes in the developing brain and their modifications by neonatal hypoxic-ischemic (HI) brain injury. In this study, the postsynaptic density proteins were prepared from postnatal day 9 naïve, sham-operated and HI-injured mouse cortex...
October 6, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28992629/%C3%AE-lipoic-acid-promotes-neurological-recovery-after-ischemic-stroke-by-activating-the-nrf2-ho-1-pathway-to-attenuate-oxidative-damage
#18
Chengmei Lv, Surendra Maharjan, Qingqing Wang, Yongxin Sun, Xu Han, Shan Wang, Zhengchun Mao, Yanming Xin, Bing Zhang
BACKGROUND/AIMS: Alpha-lipoic acid (α-LA) has been demonstrated to be protective against cerebral ischemia injury. Herein, we investigate the neuroprotective effect and underlying mechanisms of α-LA. METHODS: In vivo study, α-LA was administered intravenously upon reperfusion of transient middle cerebral artery occlusion. Garcia score was used to evaluate neurologic recovery. Infarct volume was examined by TTC staining, and oxidative damage was evaluated by ELISA assay...
October 9, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28988529/effect-of-anesthetics-on-efficiency-of-remote-ischemic-preconditioning
#19
D N Silachev, E A Usatikova, I B Pevzner, L D Zorova, V A Babenko, M V Gulyaev, Yu A Pirogov, E Yu Plotnikov, D B Zorov
Remote ischemic preconditioning of hind limbs (RIPC) is an effective method for preventing brain injury resulting from ischemia. However, in numerous studies RIPC has been used on the background of administered anesthetics, which also could exhibit neuroprotective properties. Therefore, investigation of the signaling pathways triggered by RIPC and the effect of anesthetics is important. In this study, we explored the effect of anesthetics (chloral hydrate and Zoletil) on the ability of RIPC to protect the brain from injury caused by ischemia and reperfusion...
September 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28987955/the-effects-of-dexmedetomidine-preconditioning-on-aged-rat-heart-of-ischaemia-reperfusion-injury
#20
Jing Dong, Xin Guo, Shuhua Yang, Lin Li
To assess the effect of dexmedetomidine on myocardial ischemia reperfusion injury in vivo aged rat heart. 40 healthy male, 20month aged, 350-400g Sprague-Dawley rats. Rats were divided into four groups randomly(n=10): group of ischemic preconditioning(IP group), group of Sham(CS group), group of dexmedetomidine(DP group), Ischemia-reperfusion injury group(IR group). The date of HR and ±dp/dtmax were detected before and after the occur of ischemia reperfusion. Superoxide dismutase (SOD) and malondialdehyde (MDA) activity were recorded; myocardial infarct size was calculated at the end of reperfusion...
September 28, 2017: Research in Veterinary Science
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