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ischemic reperfusion injury

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https://www.readbyqxmd.com/read/29689742/microsurgical-repair-of-neonatal-iliac-artery-injuries-with-saphenous-vein-grafts
#1
Karri A Adamson, Matthew E Braza, John A LoGiudice, William W Dzwierzynski
Two neonates with congenital heart disease, one and thirty-one days old respectively, suffered inadvertent arterial injury from cardiac catheterization. Both insults resulted in unrecognized avulsion of the external iliac artery from its origin. The patients quickly decompensated, with their right lower extremities becoming critically ischemic. In both cases, segments of reversed greater saphenous vein were used as interposition grafts from the common iliac artery to the common femoral artery. Reperfusion of the right foot was immediate for the one-day-old...
2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29689567/ampk-contributes-to-cardioprotective-effects-of-pterostilbene-against-myocardial-ischemia-reperfusion-injury-in-diabetic-rats-by-suppressing-cardiac-oxidative-stress-and-apoptosis
#2
Ramoji Kosuru, Yin Cai, Vidya Kandula, Dan Yan, Chunyan Wang, Hong Zheng, Yalan Li, Michael G Irwin, Sanjay Singh, Zhengyuan Xia
BACKGROUND/AIMS: Pterostilbene (PT) exerts antidiabetic effects by decreasing blood glucose and modulating lipid metabolism and has been shown to attenuate myocardial ischemia-reperfusion (IR) injury in non-diabetic subjects. However, whether PT can protect against myocardial IR injury in diabetes is unknown. AMPK stimulation is indispensable in offering cardioprotection against myocardial IR injury in diabetes by limiting cardiac apoptosis. Thus, we hypothesized that PT may confer protection against myocardial IR injury in diabetes via AMPK activation...
April 18, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29689553/microrna-374-exerts-protective-effects-by-inhibiting-sp1-through-activating-the-pi3k-akt-pathway-in-rat-models-of-myocardial-ischemia-reperfusion-after-sevoflurane-preconditioning
#3
Shu-Bo Zhang, Tie-Jun Liu, Guo-Hua Pu, Bao-Yong Li, Xiao-Zeng Gao, Xiao-Liang Han
BACKGROUND/AIMS: Ischemic heart disease is a leading cause of death in cardiovascular diseases, and microRNAs (miRs) have been reported to be potential therapeutic targets in heart disease. Herein, this study aims to investigate the effects of microRNA (miR)-374 on myocardial ischemia-reperfusion (I/R) injury in rat models pretreated with sevoflurane by targeting SP1 through the PI3K/Akt pathway. METHODS: SD rats were grouped into sham, I/R and sevoflurane + I/R (sevoflurane preconditioning and I/R) groups...
April 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29688134/genistein-attenuates-brain-damage-induced-by-transient-cerebral-ischemia-through-up-regulation-of-nrf2-expression-in-ovariectomized-rats
#4
Zhong-Yan Miao, Xu Xia, Lu Che, Yan-Tao Song
OBJECTIVE: Postmenopausal women possess higher incidence of stroke and worse prognosis. Although estrogen replacement therapy has obvious neuroprotective effects against stroke, it is always accompanied with several adverse effects and undesired outcomes. Genistein, a natural phytoestrogen, has been indicated to be a potential neuroprotective alternative for postmenopausal women against stroke. However, the role and mechanism of genistein's neuroprotective effects against stroke in ovariectomized rats have rarely been explored...
April 24, 2018: Neurological Research
https://www.readbyqxmd.com/read/29687873/renal-ischemia-reperfusion-injury-attenuated-by-splenic-ischemic-preconditioning
#5
Y Shen, T Qiu, X-H Liu, L Zhang, Z-S Wang, J-Q Zhou
OBJECTIVE: To investigate the therapeutic effect of splenic ischemic preconditioning (sIPC) on renal ischemia-reperfusion (IR) injury. MATERIALS AND METHODS: A total of 18 adult male Sprague Dawley (SD) rats were treated by 45 min renal ischemia and followed by 24 h reperfusion. In the sIPC group, three cycles of splenic ischemic preconditioning including 5 min ischemia and 5 min reperfusion were carried out before renal ischemia. The blood samples and kidney tissues were collected after 24 h...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29683999/normothermic-ex-vivo-kidney-perfusion-reduces-warm-ischemic-injury-of-porcine-kidney-grafts-retrieved-after-circulatory-death-dcd
#6
Matyas Hamar, Peter Urbanellis, Moritz Johann Kaths, Dagmar Kollmann, Ivan Linares, Sujani Ganesh, Aryn Wiebe, Jun Yu Cen, Paul M Yip, Rohan John, Ana Konvalinka, Istvan Mucsi, Anand Ghanekar, Darius Bagli, David R Grant, Lisa A Robinson, Markus Selzner
BACKGROUND: Cold storage is poorly tolerated by kidney grafts retrieved after Donation after Circulatory Death (DCD). It has been determined that normothermic ex vivo kidney perfusion (NEVKP) preservation decreases injury by minimizing cold ischemic storage. The impact of NEVKP on warm ischemic injury is unknown. METHODS: We compared pig kidneys retrieved after 30minutes warm ischemia and immediate transplantation (no-preservation) with grafts that were exposed to 30min of warm ischemia plus 8hr NEVKP or plus 8hr SCS...
April 21, 2018: Transplantation
https://www.readbyqxmd.com/read/29681850/-tnfrsf12a-mediated-atherosclerosis-signaling-and-inflammatory-response-as-a-common-protection-mechanism-of-shuxuening-injection-against-both-myocardial-and-cerebral-ischemia-reperfusion-injuries
#7
Ming Lyu, Ying Cui, Tiechan Zhao, Zhaochen Ning, Jie Ren, Xingpiao Jin, Guanwei Fan, Yan Zhu
Shuxuening injection (SXNI) is a widely prescribed herbal medicine of Ginkgo biloba extract (EGB) for cerebral and cardiovascular diseases in China. However, its curative effects on ischemic stroke and heart diseases and the underlying mechanisms remain unknown. Taking an integrated approach of RNA-seq and network pharmacology analysis, we compared transcriptome profiles of brain and heart ischemia reperfusion injury in C57BL/6J mice to identify common and differential target genes by SXNI. Models for myocardial ischemia reperfusion injury (MIRI) by ligating left anterior descending coronary artery (LAD) for 30 min ischemia and 24 h reperfusion and cerebral ischemia reperfusion injury (CIRI) by middle cerebral artery occlusion (MCAO) for 90 min ischemia and 24 h reperfusion were employed to identify the common mechanisms of SXNI on both cerebral and myocardial ischemia reperfusion...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29681725/the-effects-of-bevacizumab-treatment-in-a-rat-model-of-retinal-ischemia-and-perfusion-injury
#8
Maryo Cenk Kohen, Sinan Tatlipinar, Alev Cumbul, Ünal Uslu
Purpose: To create a model of an ischemic retina with temporary ischemia and reperfusion (IR) and to examine the possible antiapoptotic and neurodegenerative effects of a vascular endothelial growth factor (VEGF) antagonist. Methods: Three groups were formed. Rats were subjected to continued ischemia for 45 min, and then reperfusion was allowed for 2 days. For the first group, ischemia was induced, but an anti-VEGF agent was not administered. For the second group, 2 days before ischemia, 0...
2018: Molecular Vision
https://www.readbyqxmd.com/read/29681568/microrna-208a-regulates-h9c2-cells-simulated-ischemia-reperfusion-myocardial-injury-via-targeting-chd9-through-notch-nf-kappa-b-signal-pathways
#9
Shouwen Zhang, Rongjun Zhang, Fangfang Wu, Xinhua Li
Ischemic reperfusion (I/R) injury is a serious problem in the treatment of ischemic heart disease. MicroRNA-208a (miR-208a) is a cardiac-specific or cardiac-enriched miRNA. This study was aimed to assess the role of miR-208a in I/R injury. H9c2 cells were used to simulate I/R injury in vitro. miR-208a expression level was measured by qPCR. H9c2 cells after simulated I/R injury were transfected with miR-208a mimic, AOS-miR-208a or negative controls. LDH release, MDA and SOD contents were measured by corresponding purchased detection kits, respectively...
April 20, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29674665/the-proximal-tubular-%C3%AE-7-nicotinic-acetylcholine-receptor-attenuates-ischemic-acute-kidney-injury-through-akt-pkc-signaling-mediated-ho-1-induction
#10
Hwajin Kim, So Ra Kim, Jihyun Je, Kyuho Jeong, Sooji Kim, Hye Jung Kim, Ki Churl Chang, Sang Won Park
Activation of the α7 nicotinic acetylcholine receptor (α7nAChR) has been shown to attenuate excessive inflammation by inhibiting proinflammatory cytokines during ischemia-reperfusion (IR) injury; however, the underlying kidney-specific molecular mechanisms remain unclear. The protective action of α7nAChR against renal IR injury was investigated using a selective α7nAChR agonist and antagonist. α7nAChR activation reduced plasma creatinine levels and tubular cell damage, whereas α7nAChR inhibition aggravated the IR-induced phenotype...
April 20, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29673933/lysophosphatidic-acid-induces-neuronal-cell-death-via-activation-of-asparagine-endopeptidase-in-cerebral-ischemia-reperfusion-injury
#11
Chao Wang, Jie Zhang, Junchun Tang, Yi-Yi Li, YanXia Gu, Ying Yu, Jing Xiong, Xueqing Zhao, Zheng Zhang, Ting-Ting Li, Jutao Chen, Qi Wan, Zhaohui Zhang
Lysophosphatidic acid (LPA), an extracellular signaling molecule, influences diverse biological events, including the pathophysiological process induced after ischemic brain injury. However, the molecular mechanisms mediating the pathological change after ischemic stroke remain elusive. Here we report that asparagine endopeptidase (AEP), a lysosomal cysteine proteinase, is regulated by LPA during stroke. AEP proteolytically cleaves tau and generates tauN368 fragments, triggering neuronal death. Inhibiting the generation of LPA reduces the expression of AEP and tauN368, and alleviates neuronal cell death...
April 16, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29672298/intermittent-hypoxia-inhibits-na-h-exchange-mediated-acid-extrusion-via-intracellular-na-accumulation-in-cardiomyocytes
#12
Huai-Ren Chang, Chih-Feng Lien, Jing-Ren Jeng, Jen-Che Hsieh, Chen-Wei Chang, Jian-Hong Lin, Kun-Ta Yang
BACKGROUND/AIMS: Intermittent hypoxia (IH) has been shown to exert preconditioning-like cardioprotective effects. It also has been reported that IH preserves intracellular pH (pHi) during ischemia and protects cardiomyocytes against ischemic reperfusion injury. However, the exact mechanism is still unclear. METHODS: In this study, we used proton indicator BCECF-AM to analyze the rate of pHi recovery from acidosis in the IH model of rat neonatal cardiomyocytes. Neonatal cardiomyocytes were first treated with repetitive hypoxia-normoxia cycles for 1-4 days...
April 16, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29671210/indian-ginseng-withania-somnifera-supplementation-ameliorates-oxidative-stress-and-mitochondrial-dysfunctions-in-experimental-model-of-stroke
#13
Abhilasha Sood, Arpit Mehrotra, Devinder K Dhawan, Rajat Sandhir
Stroke is an increasingly prevalent clinical condition and second leading cause of death globally. The present study evaluated the therapeutic potential of Indian Ginseng, also known as Withania somnifera (WS), supplementation on middle cerebral artery occlusion (MCAO) induced mitochondrial dysfunctions in experimental model of ischemic stroke. Stroke was induced in animals by occluding the middle cerebral artery, followed by reperfusion injury. Ischemia reperfusion injury resulted in increased oxidative stress indicated by increased reactive oxygen species and protein carbonyl levels; compromised antioxidant system; in terms of reduced superoxide dismutase and catalase activity, along with reduction in GSH levels and the redox ratio, impaired mitochondrial functions and enhanced expression of apoptosis markers...
April 18, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29671019/lixisenatide-a-novel-glp-1-analog-protects-against-cerebral-ischemia-reperfusion-injury-in-diabetic-rats
#14
Rania G Abdel-Latif, Gehan H Heeba, Ashraf Taye, Mohamed M A Khalifa
Type 2 diabetes mellitus (T2DM) is a major risk factor for ischemic stroke accompanied by vascular dysfunction and poor cerebrovascular outcome. Lixisenatide is a glucagon like peptide-1 (GLP-1) analog that is recently used for T2DM treatment with established neuroprotective properties. This study investigated and compared the neuroprotective effect of lixisenatide against glimepiride on diabetic rats subjected to global cerebral ischemia/reperfusion (I/R) injury. T2DM-induced adult male Wistar rats were administered lixisenatide or glimepiride prior to induction of global cerebral I/R-induced injury...
April 18, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29670333/upregulation-of-vascular-endothelial-growth-factor-receptor-1-contributes-to-sevoflurane-preconditioning-mediated-cardioprotection
#15
Bin Qian, Yang Yang, Yusheng Yao, Yanling Liao, Ying Lin
Purpose: Sevoflurane preconditioning (SPC) can provide myocardial protective effects similar to ischemic preconditioning. However, the exact mechanism of SPC remains unclear. Previous studies indicate that vascular endothelial growth factor receptor 1 (VEGFR-1) is involved in ischemic preconditioning-mediated cardioprotection. This study was designed to determine the significance of VEGFR-1 signaling in SPC-mediated cardioprotection. Materials and methods: Myocardial ischemia-reperfusion (I/R) rat model was established using the Langendorff isolated heart perfusion apparatus...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29669712/er-chaperone-grp78-protects-heart-from-ischemia-reperfusion-injury-through-akt-activation
#16
Xukun Bi, Guangyu Zhang, Xiaoding Wang, Chau Yt Nguyen, Herman I May, Xiaoting Li, Ali Al-Hashimi, Richard C Austin, Thomas G Gillette, Guo Sheng Fu, Zhao V Wang, Joseph A Hill
<u>Rationale:</u> Restoration of coronary artery blood flow is the most effective means of ameliorating myocardial damage triggered by ischemic heart disease. However, coronary reperfusion elicits an increment of additional injury to the myocardium. Accumulating evidence indicates that the unfolded protein response (UPR) in cardiomyocytes is activated by ischemia/reperfusion (I/R) injury. Xbp1s, the most highly conserved branch of the UPR, is protective in response to cardiac I/R injury. GRP78, a master regulator of the UPR and an Xbp1s target, is up-regulated after I/R...
April 18, 2018: Circulation Research
https://www.readbyqxmd.com/read/29667230/nephropreventing-effect-of-hypoxia-inducible-factor-1%C3%AE-in-a-rat-model-of-ischemic-reperfusion-acute-kidney-injury
#17
Huiling Wang, Nanmei Liu, Rui Li, Jun Tian, Weifeng Hu, Jinyuan Zhang
Acute kidney injury (AKI) often occurs in 5% hospitalized patients and in 50% sepsis patients with acute renal dysfunction. However, there is no safe and effective therapeutic strategies until now. Hypoxia condition is closely related to renal injuries and function under AKI. As HIF-1α is critical for cellular response to hypoxia, we investigated the protective effect of HIF-1α in a rat AKI model. We found that HIF-1 α injection improved the survival of rat with AKI, and the level of Cr and BUN was also increased...
April 17, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29665290/timely-visualization-of-the-collaterals-formed-during-acute-ischemic-stroke-with-fe-3-o-4-nanoparticle-based-mr-imaging-probe
#18
Ting Wang, Yi Hou, Bo Bu, Wenxin Wang, Tiancong Ma, Chunyan Liu, Lan Lin, Lin Ma, Xin Lou, Mingyuan Gao
Ischemic stroke is one of the major leading causes for long-term disability and mortality. Collateral vessels provide an alternative pathway to protect the brain against ischemic injury after arterial occlusion. Aiming at visualizing the collaterals occurring during acute ischemic stroke, an integrin αv β3 -specific Fe3 O4 -Arg-Gly-Asp (RGD) nanoprobe is prepared for magnetic resonance imaging (MRI) of the collaterals. Rat models are constructed by occluding the middle cerebral artery for imaging studies of cerebral ischemia and ischemia-reperfusion on 7...
April 17, 2018: Small
https://www.readbyqxmd.com/read/29665111/inhibition-of-transient-receptor-potential-vanilloid-4-decreases-the-expressions-of-caveolin-1-and-caveolin-2-after-focal-cerebral-ischemia-and-reperfusion-in-rats
#19
Hui Xie, Wei-Cheng Lu
This study aimed to investigate the effects of transient receptor potential vanilloid 4 (TRPV4) inhibition on blood-brain barrier (BBB) integrity and the expressions of caveolae structural proteins caveolin-1 and caveolin-2 in rats with focal cerebral ischemia and reperfusion. BBB permeability was assessed by Evans blue extravasation. The mRNA and protein expressions of caveolin-1 and caveolin-2 were determined by RT-PCR, Western blot and immunohistochemistry assays. We found that BBB permeability significantly increased and reaches its peak at 72 h of reperfusion in cerebral ischemia-reperfusion rats and is able to be ameliorated by administration of HC-067047, an antagonist of TRPV4...
April 17, 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29664057/remote-ischemic-postconditioning-for-ischemic-stroke-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
Jing-Jing Zhao, Hui Xiao, Wen-Bo Zhao, Xiao-Pei Zhang, Yu Xiang, Zeng-Jie Ye, Miao-Miao Mo, Xue-Ting Peng, Lin Wei
Background: Remote ischemic postconditioning (RIPostC) appears to protect distant organs from ischemia-reperfusion injury (IRI). However, cerebral protection results have remained inconclusive. In the present study, a meta-analysis was performed to compare stroke patients with and without RIPostC. Methods: CNKI, WanFang, VIP, CBM, PubMed, and Cochrane Library databases were searched up to July 2016. Data were analyzed using both fixed-effects and random-effects models by Review Manager...
April 20, 2018: Chinese Medical Journal
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