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ischemic reperfusion injury

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https://www.readbyqxmd.com/read/29232398/remote-ischemic-preconditioning-attenuates-cardiopulmonary-bypass-induced-lung-injury
#1
Xiaona Zhou, Runzhu Jiang, Yucai Dong, Lifeng Wang
The use of cardiopulmonary bypass (CPB) in cardiac surgeries is known to induce pathological changes in vital organs such as lungs. Remote ischemic preconditioning (RIPC) is a protective strategy that has shown to be able to reduce tissue damage related to ischemia-reperfusion injury (IRI). The current study seeks to evaluate the beneficial effects of limb RIPC on lung tissues and function in a rat CPB model. RIPC, which consisted of three cycles of 5-min ischemia and subsequently 5-min reperfusion, was induced in the hind limbs of the animals via a tourniquet...
2017: PloS One
https://www.readbyqxmd.com/read/29231479/-effects-of-electroacupuncture-preconditioning-on-expression-of-aquaporin-1-and-activity-of-protein-kinase-c-in-myocardium-of-rats-with-acute-myocardial-ischemia-reperfusion-injury
#2
Ronglin Cai, Ling Hu, Guoming Shen, Qing Yu, Jie Wang, Zijian Wu, Meng Li
OBJECTIVE: To explore the partial action mechanism and the myocardial protective effect differences between electroacupuncture (EA) preconditioning at "Neiguan"(PC 6) and "Taiyuan"(LU 9) in rats with acute myocardial ischemia-reperfusion injury. METHODS: Ninety-six Wistar rats were randomly assigned into a sham-operation group, a model group, a Neiguan group and a Taiyuan group, 24 rats in each one. The rats in the Neiguan group and Taiyuan group were treated with EA (2 Hz in frequency, 1 mA in intensity) at "Neiguan" (PC 6) and "Taiyuan" (LU 9) respectively, 20 min per treatment, once a day for consecutive 7 days...
February 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231436/-protective-effect-of-acupuncture-preconditioning-on-oxidative-stress-injury-induced-by-myocardial-ischemia-reperfusion-injury-in-rats
#3
Minglu Shao, Yang Li, Huafeng Cui, Man Jiang, Qiwen Tan
OBJECTIVE: To observe the protective effect of acupuncture preconditioning at "Jiaji" (EX-B 2) on acute myocardial ischemia-reperfusion injury (MIRI) in the rats and explore the mechanism. METHODS: Fifty Wistar rats were randomly divided into a control group, a model group, a Jiaji group, a Neiguan group and a Quchi group, 10 rats in each one. In the Jiaji group, the Neiguan group and the Quchi group, electroacupuncture was given for preconditioning at "Jiaji" T4~T5 (EX-B 2), "Neiguan" (PC 6) and "Quchi" (LI 11) for 7 days before modeling...
March 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29228414/temporal-changes-of-inflammatory-cytokine-profiles-in-epithelial-lining-fluid-in-a-canine-lung-transplant-model
#4
Atsushi Wada, Mitsutomo Kohno, Kana Oiwa, Ryo Hashimoto, Takahisa Koizumi, Yusuke Nakamura, Tomoki Nakagawa, Ryota Masuda, Kichizo Kaga, Masayuki Iwazaki
OBJECTIVES: Ischemia-reperfusion injury resulting in post-transplant lung dysfunction involves a complicated network of cytokines that has yet to be fully investigated. We analyzed temporal changes in cytokine levels in epithelial lining fluid (ELF) from the distal airways of a canine lung transplantation model. METHODS: Ischemic time was set to 18 hours to enhance lung injury in a left single-lung transplantation model. ELF was collected via bronchoscopic microsampling, a minimally-invasive technique allowing repeated sampling, hourly up to 5 hours after reperfusion started...
December 20, 2017: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/29226578/ischemia-reperfusion-injury-and-ischemic-post-conditioning-in-acute-myocardial-infarction-lost-in-translation
#5
EDITORIAL
Gennaro Giustino, George D Dangas
Ischemic post-conditioning (IPoC) has been proposed as a strategy to mitigate the risk of ischemia-reperfusion injury during primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI). In this comprehensive and updated meta-analysis of randomized controlled trials, IPoC during primary PCI for STEMI had no significant effect on all-cause mortality, re-infarction, or new-onset heart failure compared with no post-conditioning. Further strategies need to be prospectively evaluated to improve outcomes in patients with STEMI undergoing primary PCI...
December 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29224834/hdac1-localizes-to-the-mitochondria-of-cardiac-myocytes-and-contributes-to-early-cardiac-reperfusion-injury
#6
Daniel J Herr, Mauhamad Baarine, Sverre E Aune, Xiaoyang Li, Lauren E Ball, John J Lemasters, Craig C Beeson, James C Chou, Donald R Menick
RATIONALE: Recent evidence indicates that histone deacetylase enzymes (HDACs) contribute to ischemia reperfusion (I/R) injury, and pan-HDAC inhibitors have been shown to be cardioprotective when administered either before an ischemic insult or during reperfusion. We have shown previously that selective inhibition of class I HDACs provides superior cardioprotection when compared to pan-HDAC inhibition in a pretreatment model, but selective class I HDAC inhibition has not been tested during reperfusion, and specific targets of class I HDACs in I/R injury have not been identified...
December 7, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29215306/a-peptide-mimetic-of-tyrosine-phosphatase-step-as-a-potential-therapeutic-agent-for-treatment-of-cerebral-ischemic-stroke
#7
Ranjana Poddar, Sathyanarayanan Rajagopal, Lucas Winter, Andrea M Allan, Surojit Paul
Extensive research over the last two decades has advanced our understanding of the pathophysiology of ischemic stroke. However, current pharmacologic therapies are still limited to rapid reperfusion using thrombolytic agents, and neuroprotective approaches that can reduce the consequences of ischemic and reperfusion injury, are still not available. To bridge this gap, we have evaluated the long-term efficacy and therapeutic time window of a novel peptide-based neuroprotectant TAT-STEP, derived from the brain-enriched and neuron-specific tyrosine phosphatase STEP...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29213350/immediate-early-response-gene-x-1-iex-1-mediates-ischemic-preconditioning-induced-cardioprotection-in-rats
#8
Ming-Jiang Xu, Yan Cai, Aijuan Qu, John Y-J Shyy, Wenjing Li, Xian Wang
Reversible myocardial ischemia/reperfusion (I/R) or ischemic preconditioning (IPC) is associated with an immediate genomic response; IPC-induced immediate early genes are associated with reduced infarct size. Because the immediate early response gene X-1 (IEX-1) plays a central role in cell apoptosis, we examine whether IEX-1 exerts protective effects against I/R injury. We found that the IEX-1 mRNA level was increased in the IPC-imposed rat heart. However, it was downregulated in the I/R rat heart, which was prevented by in situ IPC...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29211056/krebs-cycle-metabolites-and-preferential-succinate-oxidation-following-neonatal-hypoxic-ischemic-brain-injury-in-mice
#9
Prateek V Sahni, Jimmy Zhang, Sergey Sosunov, Alexander Galkin, Zoya Niatsetskaya, Anatoly Starkov, Paul S Brookes, Vadim S Ten
BackgroundReverse electron transport (RET) driven by the oxidation of succinate has been proposed as the mechanism of accelerated production of reactive oxygen species (ROS) in post-ischemic mitochondria. However, it remains unclear whether upon reperfusion, mitochondria preferentially oxidase succinate.MethodsNeonatal mice were subjected to Rice-Vannucci model of hypoxic-ischemic brain injury (HI) followed by assessment of Krebs cycle metabolites, mitochondrial substrate preference, and H2O2 generation rate in the ischemic brain...
December 6, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29209166/mir-145-5p-nurr1-tnf-%C3%AE-signaling-induced-microglia-activation-regulates-neuron-injury-of-acute-cerebral-ischemic-reperfusion-in-rats
#10
Xuemei Xie, Li Peng, Jin Zhu, Yang Zhou, Lingyu Li, Yanlin Chen, Shanshan Yu, Yong Zhao
Nurr1 is a member of the nuclear receptor 4 family of orphan nuclear receptors that is decreased in inflammatory responses and leads to neurons death in Parkinson's disease. Abnormal expression of Nurr1 have been attributed to various signaling pathways, but little is known about microRNAs (miRNAs) regulation of Nurr1 in ischemia/reperfusion injury. To investigate the post transcriptional regulatory networks of Nurr1, we used a miRNA screening approach and identified miR-145-5p as a putative regulator of Nurr1...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29207618/neuroprotective-effect-of-a-novel-gastrodin-derivative-against-ischemic-brain-injury-involvement-of-peroxiredoxin-and-tlr4-signaling-inhibition
#11
Xiao-Na Mao, Hong-Jing Zhou, Xiao-Jia Yang, Li-Xue Zhao, Xi Kuang, Chu Chen, Dong-Ling Liu, Jun-Rong Du
The inhibition of extracellular inflammatory peroxiredoxin (Prx) signaling appears to be a potential therapeutic strategy for neuroinflammatory injury after acute ischemic stroke. Gastrodin (Gas) is a phenolic glycoside that is used for the treatment of cerebral ischemia, accompanied by regulation of the autoimmune inflammatory response. The present study investigated the neuroprotective effects of Gas and its derivative, Gas-D, with a focus on the potential mechanism associated with inflammatory Prx-Toll-like receptor 4 (TLR4) signaling...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29206849/cilostazol-attenuates-intimal-hyperplasia-in-a-mouse-model-of-chronic-kidney-disease
#12
Wiwat Chancharoenthana, Asada Leelahavanichkul, Sujittra Taratummarat, Jutamas Wongphom, Khajohn Tiranathanagul, Somchai Eiam-Ong
Intimal hyperplasia (IH) is a common cause of vasculopathy due to direct endothelial damage (such as post-coronary revascularization) or indirect injury (such as chronic kidney disease, or CKD). Although the attenuation of coronary revascularization-induced IH (direct-vascular-injury-induced IH) by cilostazol, a phosphodiesterase III inhibitor, has been demonstrated, our understanding of the effect on CKD-induced IH (indirect-vascular-injury-induced IH) is limited. Herein, we tested if cilostazol attenuated CKD-induced IH in a mouse model of ischemic-reperfusion injury with unilateral nephrectomy (Chr I/R), a normotensive non-proteinuria CKD model...
2017: PloS One
https://www.readbyqxmd.com/read/29202762/myocyte-membrane-and-microdomain-modifications-in-diabetes-determinants-of-ischemic-tolerance-and-cardioprotection
#13
REVIEW
Jake Russell, Eugene F Du Toit, Jason N Peart, Hemal H Patel, John P Headrick
Cardiovascular disease, predominantly ischemic heart disease (IHD), is the leading cause of death in diabetes mellitus (DM). In addition to eliciting cardiomyopathy, DM induces a 'wicked triumvirate': (i) increasing the risk and incidence of IHD and myocardial ischemia; (ii) decreasing myocardial tolerance to ischemia-reperfusion (I-R) injury; and (iii) inhibiting or eliminating responses to cardioprotective stimuli. Changes in ischemic tolerance and cardioprotective signaling may contribute to substantially higher mortality and morbidity following ischemic insult in DM patients...
December 4, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29201192/daidzein-ameliorates-spinal-cord-ischemia-reperfusion-injury-induced-neurological-function-deficits-in-sprague-dawley-rats-through-pi3k-akt-signaling-pathway
#14
Fan Zhang, Neng Ru, Zheng-Hui Shang, Jian-Feng Chen, Chao Yan, Yun Li, Jie Liang
Daidzein (DZ) has a broad spectrum of biological activities, including antioxidant, anti-inflammatory and anticancer as well as cardio- and hepatoprotective properties. The present study was designed to elucidate the in-depth mechanism underlying the neuroprotective efficacy of DZ against spinal cord ischemic/reperfusion injury (SCII) in a rat model by comparison with the standard neuroprotective agent methylprednisolone (MP). A total of 48 rats were divided into four groups of twelve rats in each (n=12). In sham-operated group (Control) group, rats received only saline (Fogarty catheter was inserted without balloon inflation), whereas rats in the SCII induction group (SCII) were subjected to SCII insult by insertion of a Fogarty balloon catheter, which was inflated in the descending thoracic aorta to cause an occlusion...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29200946/combined-hemorrhagic-shock-and-unilateral-common-carotid-occlusion-induces-neurological-injury-in-adult-male-rats
#15
Chung-Ching Chio, Chien-Chin Hsu, Yu-Feng Tian, Chung-Han Wang, Mao-Tsun Lin, Ching-Ping Chang, Hung-Jung Lin
Background: Clinical assessment reveals that patients after surgery of cardiopulmonary bypass or coronary bypass experience postoperative cognitive dysfunction. This study aimed to investigate whether resuscitation after a hemorrhagic shock (HS) and/or mild cerebral ischemia caused by a unilateral common carotid artery occlusion (UCCAO) can cause brain injury and concomitant neurological dysfunction, and explore the potential mechanisms. Methods: Blood withdrawal (6 mL/100 g body weight) for 60 min through the right jugular vein catheter-induced an HS...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29198964/madecassoside-protects-bv2-microglial-cells-from-oxygen-glucose-deprivation-reperfusion-induced-injury-via-inhibition-of-the-toll-like-receptor-4-signaling-pathway
#16
Yuan Luo, Cheng Wang, Wan-Hua Li, Jie Liu, Jun Yang, Xin Sui, Shuai Wang, Zili You, Yong-An Wang
In a previous study, the authors reported that madecassoside (MA) exerted a potent neuroprotective effect against cerebral ischemia-reperfusion (I/R) injury in rats, mediated by anti-oxidative, anti-inflammatory, and anti-apoptotic mechanisms. However, the cellular and molecular bases for its neuroprotective effects have not been fully elucidated. In this study, an in vitro ischemic model of oxygen-glucose deprivation followed by reperfusion (OGD/R) was used to investigate the role of the toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor-kappa B (NF-κB) pathway in the neuroprotective and anti-inflammatory effects of MA...
November 30, 2017: Brain Research
https://www.readbyqxmd.com/read/29198128/proprotein-convertase-1-mediated-proneuropeptide-proteolytic-processing-in-ischemic-neuron-injury
#17
S S Tang, Z Y Liang, L R Guo, J H Zhang, D Zhou
BACKGROUND: Pro-protein processing mechanism plays an important role in neuron injury. OBJECTIVE: To study the protein convertase 1 (PC1) mediated processing mechanism, the ischemic cellular or tissue proPC1/PC1 or proCgA/CgA (pro-chromogranin A) was analyzed. METHODS: NS20Y differentiated cells were stressed by 0-6 h of oxygen and glucose deprivation (OGD) in glucose-free DMEM and an anaerobic jar environment. Ischemic C57BL/J mouse model was established by performing 60-min of middle cerebral artery occlusion (MCAO) operation and subsequent 4 or 24-h reperfusion...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29198014/inhibition-of-complement-drives-increase-in-early-growth-response-proteins-and-neuroprotection-mediated-by-salidroside-after-cerebral-ischemia
#18
Wenfang Lai, XiuLi Xie, Xiaoqin Zhang, Yingzheng Wang, Kedan Chu, John Brown, Lidian Chen, Guizhu Hong
Salidroside is neuroprotective across a wide therapeutic time-window after cerebral ischemia-reperfusion injury (IRI). Here, we investigated the role of complement in mediating effects of salidroside after cerebral IRI in rats. Rats were administrated with vehicle or salidroside 50 mg/kg, given daily for either 24 or 48 h, after middle cerebral artery occlusion (MCAO) for 2 h and reperfusion for 1 h. Levels of proteins in ischemic brain were measured by immunofluorescence and western blotting. We observed early increases in the deposition of immunoglobulin M, mannose-binding lectin 2, and annexin IV on cerebral endothelial cells, induction of the complement components C3 and C3a, by 24 h after IRI, and a later significant increase in the complement component C1q by 48 h...
December 2, 2017: Inflammation
https://www.readbyqxmd.com/read/29197607/inflammatory-response-modulation-through-a-ppar%C3%AE-agonist-during-surgically-induced-visceral-ischemia-in-an-animal-model
#19
Bianca Pane, Valerio Gazzola, Giovanni Spinella, Paola Bagnato, Federica Grillo, Valerio Gaetano Vellone, Domenico Palombo
BACKGROUND: Ischemia / reperfusion (I/R) injury represents one of the most severe complications in vascular surgery where cross-clamping of the aorta and subsequent visceral ischemia are a recurrent issue. The literature describes a family of nuclear receptors, i.e., peroxisome-proliferator activated receptors (PPARs), in particular PPARγ isoform, which are important modulators of vascular inflammation resulting from I/R injury. The aim of our study is to evaluate how PPARγ agonist administration could reduce local and systemic inflammatory response after I/R injury during aortic supraceliac clamping in animal model...
November 29, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29196198/neurosurgical-modeling-of-retinal-ischemia-reperfusion-injury
#20
Alireza P Shabanzadeh, Philippe M D'Onofrio, Philippe P Monnier, Paulo D Koeberle
BACKGROUND: A reliable model of ischemia-reperfusion is required to evaluate the efficacy and safety of neuroprotective therapies for stroke. We present a novel reproducible pterygopalatine-ophthalmic artery ligation model of ischemia-reperfusion injury in the retina. METHODS: Rats were subjected to ophthalmic artery/meningeal sheath ligation (OAML-standard method) or clamping of the pterygopalatine-ophthalmic artery (OAC-new method) for 30 minutes. Retinal ganglion cell (RGC) survival was assessed by prelabeling with FluoroGold (FG) (Santa Cruz Biotechnology, CA, USA) and RNA-binding protein with multiple splicing (RBPMS) at 14 days after ischemia, and all results were compared with a sham group (n = 7 in each group)...
November 29, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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