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Coordination disorders

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https://www.readbyqxmd.com/read/29786676/-the-modern-approaches-to-the-restoration-of-postural-balance-in-the-patients-suffering-from-the-consequences-of-an-acute-cerebrovascular-accident-cva
#1
S A Volovets, E Y Sergeenko, L Y Darinskaya, B A Polyaev, Y A Yashinina, M A Isaeva, I V Zhitareva, A N Lobov, T I Panova
BACKGROUND: the most frequent and severe consequences of an acute cerebrovascular accident (CVA) are locomotor and coordination disorders which significantly increase the risk of falling in a static position and when walking. The methods used for the rehabilitation of the affected patients are designed in the first place to enable the patients to acquire the skills necessary for maintaining the static balance. The modern equipment allows to carry out coordination training in the static position and also during walking...
May 21, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29784223/the-effect-of-a-community-mental-health-training-program-for-multidisciplinary-staff
#2
Bing Xiang Yang, Teresa E Stone, Scott A Davis
BACKGROUND: Primary health workers play a critical role in providing health education to people with mental disorders. In China community health workers working with people with mental health problems lack experience and training in this area. Additionally, coordination between hospital and community staff is not well established. The aim of this study was to provide an interdisciplinary community mental health training program and to evaluate the effect of the training on staff knowledge about mental health and confidence in their roles...
June 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29784164/serum-drops-for-ocular-surface-disease-national-survey-of-canadian-cornea-specialists
#3
Michael Marchand, Mona Harissi-Dagher, Marc Germain, Paul Thompson, Marie-Claude Robert
OBJECTIVE: To review the use and preparation of serum drops for the treatment of ocular surface disease in Canada and to assess the need for an improved access to this therapy. DESIGN: Cross-sectional study. PARTICIPANTS: Cornea specialist members of the Canadian Ophthalmological Society and Canadian laboratories preparing serum tears. METHODS: A confidential survey was emailed to participants in April 2016 and continued through September 2016...
June 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29783181/autistic-traits-in-epilepsy-models-why-when-and-how
#4
REVIEW
Jana Velíšková, Jill L Silverman, Melissa Benson, Pierre-Pascal Lenck-Santini
Autism spectrum disorder (ASD) is a common comorbidity of epilepsy and seizures and/or epileptiform activity are observed in a significant proportion of ASD patients. Current research also implies that autistic traits can be observed to a various degree in mice and rats with seizures. This suggests that there are shared mechanisms in both ASD and epilepsy syndromes. Here, we first review the standard, validated methods used to assess autistic traits in animal models as well as their limitations with regards to epilepsy models...
May 18, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29782926/decoding-cell-signalling-and-regulation-of-oligodendrocyte-differentiation
#5
REVIEW
A K Santos, M S Vieira, R Vasconcellos, V A M Goulart, A H Kihara, R R Resende
Oligodendrocytes are fundamental for the functioning of the nervous system; they participate in several cellular processes, including axonal myelination and metabolic maintenance for astrocytes and neurons. In the mammalian nervous system, they are produced through waves of proliferation and differentiation, which occur during embryogenesis. However, oligodendrocytes and their precursors continue to be generated during adulthood from specific niches of stem cells that were not recruited during development. Deficiencies in the formation and maturation of these cells can generate pathologies mainly related to myelination...
May 18, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29779547/policy-pathways-to-address-provider-workforce-barriers-to-buprenorphine-treatment
#6
Rebecca L Haffajee, Amy S B Bohnert, Pooja A Lagisetty
At least 2.3 million people in the U.S. have an opioid use disorder, less than 40% of whom receive evidence-based treatment. Buprenorphine used as part of medication-assisted treatment has high potential to address this gap because of its approval for use in non-specialty outpatient settings, effectiveness at promoting abstinence, and cost effectiveness. However, less than 4% of licensed physicians are approved to prescribe buprenorphine for opioid use disorder, and approximately 47% of counties lack a buprenorphine-waivered physician...
June 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29778241/dual-autonomic-inhibitory-action-of-central-apelin-on-gastric-motor-functions-in-rats
#7
Mehmet Bülbül, Osman Sinen
Centrally administered apelin has been shown to inhibit gastric emptying (GE) in rodents, however, the relevant mechanism has been investigated incompletely. Using male Wistar rats, we investigated the efferent pathways involved in gastroinhibitory action of central apelin. Stereotaxic intracerebroventricular (icv) cannulation, subdiaphragmatic vagotomy (VGX) and/or celiac ganglionectomy (CGX) were performed 7 days prior to the experiments. Apelin-13 was administered (30 nmol, icv) 90 min prior to GE measurement...
July 2018: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29776035/unifying-model-for-random-matrix-theory-in-arbitrary-space-dimensions
#8
Giovanni M Cicuta, Johannes Krausser, Rico Milkus, Alessio Zaccone
A sparse random block matrix model suggested by the Hessian matrix used in the study of elastic vibrational modes of amorphous solids is presented and analyzed. By evaluating some moments, benchmarked against numerics, differences in the eigenvalue spectrum of this model in different limits of space dimension d, and for arbitrary values of the lattice coordination number Z, are shown and discussed. As a function of these two parameters (and their ratio Z/d), the most studied models in random matrix theory (Erdos-Renyi graphs, effective medium, and replicas) can be reproduced in the various limits of block dimensionality d...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29775292/entropy-as-a-driver-of-selectivity-for-inhibitor-binding-to-histone-deacetylase-6
#9
Nicholas J Porter, Florence F Wagner, David W Christianson
Among the metal-dependent histone deacetylases, the class IIb isozyme HDAC6 is remarkable because of its role in the regulation of microtubule dynamics in the cytosol. Selective inhibition of HDAC6 results in microtubule hyperacetylation, leading to cell cycle arrest and apoptosis, which is a validated strategy for cancer chemotherapy and the treatment of other disorders. HDAC6 inhibitors generally consist of a Zn2+ -binding group such as a hydroxamate, a linker, and a capping group; the capping group is a critical determinant of isozyme selectivity...
May 18, 2018: Biochemistry
https://www.readbyqxmd.com/read/29774655/ctc1-stn1-coordinates-g-and-c-strand-synthesis-to-regulate-telomere-length
#10
Peili Gu, Shuting Jia, Taylor Takasugi, Eric Smith, Jayakrishnan Nandakumar, Eric Hendrickson, Sandy Chang
Coats plus (CP) is a rare autosomal recessive disorder caused by mutations in CTC1, a component of the CST (CTC1, STN1, and TEN1) complex important for telomere length maintenance. The molecular basis of how CP mutations impact upon telomere length remains unclear. The CP CTC1L1142H mutation has been previously shown to disrupt telomere maintenance. In this study, we used CRISPR/Cas9 to engineer this mutation into both alleles of HCT116 and RPE cells to demonstrate that CTC1:STN1 interaction is required to repress telomerase activity...
May 17, 2018: Aging Cell
https://www.readbyqxmd.com/read/29774619/different-types-of-multiple-synapse-boutons-in-the-cerebellar-cortex-between-physically-enriched-and-ataxic-mutant-mice
#11
Hyun-Wook Kim, Seunghak Oh, Seung Hwan Lee, Sanghoon Lee, Ji-Eun Na, Kea Joo Lee, Im Joo Rhyu
Experience-dependent synapse remodeling is associated with information storage in the nervous system. Neuronal synapses show alteration in various neurological and cognitive disorders in their structure and function. At the ultrastructural level, parallel fiber boutons contacting multiple spines of Purkinje cells in the cerebellar cortex are commonly observed in physiologically enriched animals as well as pathological ataxic mutants. However, the dendritic origin of those spines on parallel fiber multiple-synapse boutons (MSBs) has been poorly understood...
May 18, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29770459/identification-of-correlative-shifts-in-indices-of-brain-cholesterol-metabolism-in-the-c57bl6-mecp2-tm1-1bird-mouse-a-model-for-rett-syndrome
#12
Dieter Lütjohann, Adam M Lopez, Jen-Chieh Chuang, Anja Kerksiek, Stephen D Turley
Rett syndrome (RS) is a pervasive neurodevelopmental disorder resulting from loss-of-function mutations in the X-linked gene methyl-Cpg-binding protein 2 (MECP2). Using a well-defined model for RS, the C57BL6/Mecp2 tm1.1Bird mouse, we have previously found a moderate but persistently lower rate of cholesterol synthesis, measured in vivo, in the brains of Mecp2 -/y mice, starting from about the third week after birth. There was no genotypic difference in the total cholesterol concentration throughout the brain at any age...
May 17, 2018: Lipids
https://www.readbyqxmd.com/read/29765769/synthesis-and-crystallographic-characterization-of-2-2-bis-%C3%AE-5-penta-methyl-cyclo-penta-dien-yl-3-4-bis-tri-methyl-sil-yl-2-zircona-furan-5-one-%C3%AE%C2%BA-o-5-triisobutyl-aluminium
#13
Vladimir V Burlakov, Vyacheslav S Bogdanov, Perdita Arndt, Anke Spannenberg, Uwe Rosenthal, Torsten Beweries, Vladimir B Shur
The crystal structure of the title zwitterionic zirconocene complex containing a furan-one unit, [AlZr(C10 H15 )2 (C4 H9 )3 (C9 H18 O2 Si2 )], is reported. On reacting a zircona-furan-one with two equivalents of HAl( i -Bu)2 , disproportionation of the Lewis acid results in the formation of a triiso-butyl-aluminium fragment, Al( i -Bu)3 , which coordinates to the exocyclic carbonyl O atom of the zircona-furan-one ring. Single-crystal X-ray diffraction reveals that the zircona-furan-one ring remains intact with coordination of the aluminium to the exocyclic O atom...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29765759/crystal-structures-of-5-12-dimethyl-1-4-8-11-tetra-aza-cyclo-tetra-decane-cobalt-iii-mono-phenyl-acetyl-ide-and-bis-phenyl-acetyl-ide
#14
Benjamin M Oxley, Brandon Mash, Matthias Zeller, Susannah Banziger, Tong Ren
Reported in this contribution are the synthesis and crystal structures of new mono- and bis-phenyl-acetyl-ides based on CoIII (DMC) (DMC is 5,12-dimethyl-1,4,8,11-tetra-aza-cyclo-tetra-deca-ne). Chlorido-(5,12-dimethyl-1,4,8,11-tetra-aza-cyclo-tetra-deca-ne)(phenyl-ethyn-yl)cobalt(III) chloride-aceto-nitrile-methanol (1/1/1), [Co(C8 H5 )Cl(C12 H28 N4 )]Cl·CH3 CN·CH3 OH, 1 , and (5,12-dimethyl-1,4,8,11-tetra-aza-cyclo-tetra-deca-ne)bis-(phenyl-ethyn-yl)cobalt(III) tri-fluoro-methane-sulfonate-di-chloro-methane (2/1), [Co(C8 H5 )2 (C12 H28 N4 )]2 (CF3 SO3 )2 ·CH2 Cl2 , 2 , were prepared under weak-base conditions in satisfactory yields...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29765743/crystal-structure-of-aqua-chlorido-nitrato-%C3%AE%C2%BA-2-o-o-1-pyridin-2-yl-%C3%AE%C2%BA-n-2-pyridin-2-yl-methyl-idene-%C3%AE%C2%BA-n-hydrazine-%C3%AE%C2%BA-n-2-manganase-ii
#15
Mamour Sarr, Mayoro Diop, Elhadj Ibrahima Thiam, Aliou Hamady Barry, Mohamed Gaye, Pascal Retailleau
The search for novel manganese(II) compounds having inter-esting magnetic properties, using 1-(pyridin-2-yl)-2-(pyridin-2-yl-methyl-idene)hydrazine (H L ) as a tridendate ligand, led to the preparation of the title mononuclear material, [MnCl(NO3 )(C11 H10 N4 )(H2 O)], and the determination of its structure by XRD. The asymmetric unit comprises a discrete mol-ecule in which the cation MnII is hepta-coordinated. The environment around the cation is an almost perfect penta-gonal bipyramid. The base is defined by the two N atoms of the pyridine rings, the N atom of the imino function of the ligand and the two O atoms of the chelating bidentate nitrate ligand...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29765737/crystal-structure-and-hirshfeld-surface-analysis-of-di-aqua-bis-n-n-di-ethyl-nicotinamide-%C3%AE%C2%BA-n-1-bis-2-4-6-tri-methyl-benzoato-%C3%AE%C2%BA-o-manganese-ii
#16
Tuncer Hökelek, Safiye Özkaya, Hacali Necefoğlu
In the title centrosymmetric complex, [Mn(C10 H11 O2 )2 (C10 H14 N2 O)2 (H2 O)2 ], the MnII cation is located on an inversion centre. The four O atoms form a slightly distorted square-planar arrangement around the MnII cation, and the distorted octa-hedral coordination is completed by two pyridine N atoms at distances of 2.3289 (15) Å. The dihedral angle between the planar carboxyl-ate group and the adjacent benzene ring is 87.73 (16)°, while the benzene and pyridine rings are oriented at a dihedral angle of 43...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29765716/synthesis-and-crystal-structure-of-deca-carbon-yl-%C3%AE-3-3-7-di-thia-nonane-1-9-di-thiol-ato-bis-%C3%AE-2-propane-1-3-di-thiol-ato-nickel-ii-tetra-iron-ii-di-chloro-methane-disolvate
#17
Gan Ren, Ge Sang
The title compound,, [Fe4 Ni(C3 H6 S2 )2 (C7 H14 S4 )(CO)10 ]·2CH2 Cl2 , is reported as a biomimic model for the active site of [FeFe]-hydrogenases. Bis(2-mercaptoeth-yl)-1,3-propane-dithio ether nickel(II) was firstly introduced into [Fe2 (C3 H6 S2 )(CO)5 ] as an S-containing ligand. It coordinates with two [Fe2 (C3 H6 S2 )(CO)5 ] groups, and a five-metal core complex is formed. The Fe2 S2 core is in a butterfly conformation. The Fe-Fe distances in the [Fe2 (C3 H6 S2 )(CO)5 ] groups are 2.5126 (6) and 2...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29765708/crystal-structure-of-octa-kis-4-meth-oxy-pyridinium-bis-4-meth-oxy-pyridine-%C3%AE%C2%BA-n-tetra-kis-thio-cyanato-%C3%AE%C2%BA-n-ferrate-iii-bis-4-meth-oxypyri-dine-%C3%AE%C2%BA-n-pentakis-thio-cyanato-%C3%AE%C2%BA-n-ferrate-iii-hexa-kis-thio-cyanato-%C3%AE%C2%BA-n-ferrate-iii-with-iron-in-three-different
#18
Aleksej Jochim, Inke Jess, Christian Näther
The crystal structure of the title salt, (C6 H8 NO)8 [Fe(NCS)4 (C6 H7 NO)2 ][Fe(NCS)5 (C6 H7 NO)]2 [Fe(NCS)6 ], comprises three negatively charged octa-hedral FeIII complexes with different coordination environments in which the FeIII atoms are coordinated by a different number of thio-cyanate anions and 4-meth-oxy-pyridine ligands. Charge balance is achieved by 4-meth-oxy-pyridinium cations. The asymmetric unit consists of three FeIII cations, one of which is located on a centre of inversion, one on a twofold rotation axis and one in a general position, and ten thio-cyanate anions, two 4-meth-oxy-pyridine ligands and 4-meth-oxy-pyridinium cations (one of which is disordered over two sets of sites)...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29760681/sex-steroids-adult-neurogenesis-and-inflammation-in-cns-homeostasis-degeneration-and-repair
#19
REVIEW
Tracy A Larson
Sex steroidal hormones coordinate the development and maintenance of tissue architecture in many organs, including the central nervous systems (CNS). Within the CNS, sex steroids regulate the morphology, physiology, and behavior of a wide variety of neural cells including, but not limited to, neurons, glia, endothelial cells, and immune cells. Sex steroids spatially and temporally control distinct molecular networks, that, in turn modulate neural activity, synaptic plasticity, growth factor expression and function, nutrient exchange, cellular proliferation, and apoptosis...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29760409/histone-deacetylase-inhibitor-ms-275-restores-social-and-synaptic-function-in-a-shank3-deficient-mouse-model-of-autism
#20
Kaijie Ma, Luye Qin, Emmanuel Matas, Lara J Duffney, Aiyi Liu, Zhen Yan
Autism is a neurodevelopmental disorder characterized by social deficits and repetitive behaviors. Genetic screening has identified synaptic, transcriptional, and chromatin genes disrupted in autistic patients. Haploinsufficiency of Shank3, which encodes a scaffold protein at glutamatergic synapses, is causally linked to autism. Using a Shank3-deficient mouse model that exhibits prominent autism-like phenotypes, we have found that histone acetylation in the prefrontal cortex (PFC) is abnormally low, which can be reversed by MS-275 (also known as Entinostat, SNDX-275), a class I histone deacetylase (HDAC) inhibitor that is selectively potent in PFC...
April 19, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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