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myocadial infarct

Athanasios D Anastasilakis, Dimitrios Koulaxis, Nikoleta Kefala, Stergios A Polyzos, Jagriti Upadhyay, Eirini Pagkalidou, Fotios Economou, Chrysostomos D Anastasilakis, Christos S Mantzoros
BACKGROUND: Several myokines are produced by cardiac muscle. We investigated changes in myokine levels at the time of acute myocardial infarction (MI) and following reperfusion in relation to controls. METHODS: Patients with MI (MI Group, n=31) treated with percutaneous coronary intervention (PCI) were compared to patients with stable coronary artery disease (CAD) subjected to scheduled PCI (CAD Group, n=40) and controls with symptoms mimicking CAD without stenosis in angiography (Control Group, n=43)...
August 2017: Metabolism: Clinical and Experimental
Florian von Knobelsdorff-Brenkenhoff, Marcel Prothmann, Matthias A Dieringer, Ralf Wassmuth, André Rudolph, Wolfgang Utz, Julius Traber, Andreas Greiser, Thoralf Niendorf, Jeanette Schulz-Menger
BACKGROUND: Studying T1- and T2-mapping for discrimination of acute from chronic myocardial infarction (AMI, CMI). METHODS: Eight patients with AMI underwent CMR at 3 T acutely and after >3 months. Imaging techniques included: T2-weighted imaging, late enhancement (LGE), T2-mapping, native and post-contrast T1-mapping. Myocardial T2- and T1-relaxation times were determined for every voxel. Abnormal voxels as defined by having T2- and T1-values beyond a predefined threshold (T2 > 50 ms, native T1 > 1250 ms and post-contrast T1 < 350 ms) were highlighted and compared with LGE as the reference...
April 29, 2016: BMC Medical Imaging
Jin-feng Liu, Bin Ling
Bone marrow-derived mesenchymal stem cells (BMSCs) have the ability to regenerate myocadial tissue. BMSCs transplantation can produce cardiac-like cells,promote angiogenesis, and secrete a variety of growth factors and cytokines. This article summarizes the molecular mechanisms of myocardial repair, explores the potential regenerative capacity of cardiac muscles after myocardial infarction,and reviews the previous studies on BMSC transplantation for treatment of cardiac muscle after myocardial infarction, with an attempt to provide new insights in clinical decision-making...
February 2015: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
Andrea Rognoni, Alessadro Lupi, Chiara Cavallino, Roberta Rosso, Alessia Veia, Sara Bacchini, Angelo Sante Bongo
Acute coronary syndromes and, in paticular, ST - segment elevation myocardial infarction are the principle causes or mortality and morbidity in the industrialized countries. The manadgement of acute myocadial infarction is much debated in the literature; primary percutaneous coronary intervention is the treatment of choice. In the recent years there has been an increasing interest in the concept of adjunctive pharmacological therapy to improve outcomes in primary percutaneous coronary intervention. In the literature randomized trials of intravenous or more recently intracoronary injection of glycoprotein IIb/IIIa inhibitors have provided conflicting results with no definitive evidence for efficacy...
June 2013: Cardiovascular & Hematological Agents in Medicinal Chemistry
Lei Li, Wei Gao, Fu-Chun Zhang, Jiang-Li Han, Yuan Zhang, Gui-Song Wang, Fei She, Li-Jun Guo
A 78-year-old man presented with an eight-hour history of chest distress. Electrocardiograph and serum cardiac enzymes were suggestive of acute inferior myocardial infarction with right ventricular infarction. The patient, who underwent emergency percutaneous coronary intervention, suffered from thrombocytopenia presenting with cerebral infarction and myocadial reinfarction during haparin exposure. The laboratory test for heparin-induced thrombocytopenia (HIT) specific antibodies (heparin-platelet factor, PF4) was positive...
November 2011: Chinese Medical Journal
Jing Huang, Yong-sheng Huang
OBJECTIVE: To study the effect and mechanism of Fulu Baoxin Oral Liquid (FBOL) on lipid peroxidation (LPO), plasma nitric oxide (NO) and vascular endothelial growth factor (VEGF) in myocadial tissue of rats with acute myocardial infarction (AMI). METHODS: The contents of superoxide dismutase (SOD), malondialdehyde (MDA) and VEGF in myocardial tissue and the plasm NO level were determined by immunohistochemical method. RESULTS: Compared with those in AMI model rats, contents of SOD, plasma NO and myocardial VEGF were higher and MDA was lower obviously in the FBOL high dosage and coronary favorable medicine treated rats (P < 0...
October 2006: Chinese Journal of Integrated Traditional and Western Medicine
Ning-yuan Wang, Chuan-jiang Lu, Xue-hai Chen
OBJECTIVE: To observe whether ginsenoside Rg1 could reduce the infarcted area and improve the heart function by path of promoting bone marrow stem cells differentiated to vascular endothelial cells (VECs). METHODS: Bone marrow was drawn from rabbit's ilium and labelled with red fluorochrome DiI, then it was transferred again into the rabbit's body. The rabbits was then made into myocardiac infarction model. The model rabbits were divided into the control group and the ginsenoside Rgl treated group (treated group)...
October 2005: Chinese Journal of Integrated Traditional and Western Medicine
Mauro Feola, Alberto Biggi, Flavio Ribichini, Alba Rovere, Antonello Vado, Gianfranco Camuzzini, Eugenio Uslenghi
BACKGROUND: Renal transplant recipients should be screened for coronary artery disease. The purpose of this study was to evaluate the usefulness of thallium-201 dipyridamole myocardial perfusion single-photon emission computed tomography (SPECT) to predict major cardiac events in these patients. METHODS AND RESULTS: Eighty-two consecutive patients (61 males) in hemodialysis (HD) treatment, awaiting renal transplantation, underwent dipyridamole Tl-201 SPECT for pretransplant risk stratification...
January 2002: Journal of Nephrology
Li, Kloner
It has been suggested that there may be gender differences in the outcome of myocardial infarction and therapies. However, there is a lack of knowledge regarding the basic science of gender difference in the setting of experimental myocadial infarction. Therefore, we performed a randomized study to determine whether there is a gender-related difference in infarct size as well as arrhythmias in an experimental model of myocardial infarction. Eleven male and 10 female adult rats were studied. All rats underwent 90 minutes of left main coronary occlusion and 4 hours of reperfusion...
1995: Journal of Thrombosis and Thrombolysis
A J Moss, S Goldstein
No abstract text is available yet for this article.
May 1970: Circulation
P Walter, W Lamprecht, H Hundeshagen, H G Borst
No abstract text is available yet for this article.
1971: Cardiology
F Tomita
The purpose of this study was to clarify the clinical and prognostic significance of silent myocardial ischemia (SMI) in patients with proven ischemic heart disease using ambulatory electrocardiographic monitoring (AEM). A total of two hundreds and ninety one patients, including 131 patients with stable effort angina (EA), 125 with previous myocardial infarction (MI), 21 with variant angina (VA), and 14 with unstable angina (UA) were examined. In 141 (EA 65, MI 41, VA 21, UA 14) of these 291 patients, we investigated the frequency and characteristics of SMI...
November 1990: [Hokkaido Igaku Zasshi] the Hokkaido Journal of Medical Science
D A Sideris, F S Harocopos, C B Karamitsos, S D Moulopoulos
Myocardial hardness, defined as resistance to a pitting force, was measured on several sites of the myocardium in 20 anesthetized dogs. The durometer used for hardness measurements consisted of an indentor, 4 mm in diameter, pressed perpendicularly on the myocardium by a calibrated spring (elastic modulus 325 N/m). Hardness changes during the cardiac cycle caused movement of the indentor which interrupted a light beam falling on a photoresistance. Changes in illumination of the photoresistance resulted in resistance changes, which were recorded using a Wheatstone bridge and a DC amplifier...
March 1978: European Journal of Cardiology
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