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https://www.readbyqxmd.com/read/29686906/postmastectomy-radiation-therapy-are-we-ready-to-individualize-radiation
#1
REVIEW
Ashlyn S Everett, Drexell Hunter Boggs, Jennifer F De Los Santos
Contemporary recommendations for postmastectomy radiation have undergone a shift in thinking away from simple stage based recommendations (one size fits all) to a system that considers both tumor biology and host factors. While surgical staging has traditionally dictated indications for postmastectomy radiation therapy (PMRT), our current understanding of tumor biology, host, immunoprofiles, and tumor microenvironment may direct a more personalized approach to radiation. Understanding the interaction of these variables may permit individualization of adjuvant therapy aimed at appropriate escalation and deescalation, including recommendations for PMRT...
2018: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29673952/expression-of-c19mc-mirnas-in-hcc-associates-with-stem-cell-features-and-the-cancer-testis-genes-signature
#2
Claudia Augello, Federico Colombo, Andrea Terrasi, Elena Trombetta, Marco Maggioni, Laura Porretti, Giorgio Rossi, Silvana Guerneri, Rosamaria Silipigni, Silvano Bosari, Valentina Vaira
BACKGROUND: Intratumor heterogeneity of hepatocellular carcinoma (HCC) and, among HCC cell subsets, the cancer stem cell population (hCSC), is responsible for therapeutic resistance and disease relapse. AIMS: To characterize hCSC-enriched HCCs at the molecular level. METHODS: Side population (SP) was used to identify the hCSCs in multiple tumor sampling from different patients and primary HCCs cultures. FACS was used to immunoprofile cultures...
March 30, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29581149/high-resolution-definition-of-humoral-immune-response-correlates-of-effective-immunity-against-hiv
#3
Galit Alter, Karen G Dowell, Eric P Brown, Todd J Suscovich, Anastassia Mikhailova, Alison E Mahan, Bruce D Walker, Falk Nimmerjahn, Chris Bailey-Kellogg, Margaret E Ackerman
Defining correlates of immunity by comprehensively interrogating the extensive biological diversity in naturally or experimentally protected subjects may provide insights critical for guiding the development of effective vaccines and antibody-based therapies. We report advances in a humoral immunoprofiling approach and its application to elucidate hallmarks of effective HIV-1 viral control. Systematic serological analysis for a cohort of HIV-infected subjects with varying viral control was conducted using both a high-resolution, high-throughput biophysical antibody profiling approach, providing unbiased dissection of the humoral response, along with functional antibody assays, characterizing antibody-directed effector functions such as complement fixation and phagocytosis that are central to protective immunity...
March 26, 2018: Molecular Systems Biology
https://www.readbyqxmd.com/read/29567816/correction-for-wang-et-al-immunoprofiling-of-the-tryptophan-rich-antigen-family-in-plasmodium-vivax
#4
Bo Wang, Feng Lu, Yang Cheng, Jun-Hu Chen, Hye-Yoon Jeon, Kwon-Soo Ha, Jun Cao, Myat Htut Nyunt, Jin-Hee Han, Seong-Kyun Lee, Myat Phone Kyaw, Jetsumon Sattabongkot, Eizo Takashima, Takafumi Tsuboi, Eun-Taek Han
No abstract text is available yet for this article.
April 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29533281/a-case-of-a-malignant-cutaneous-mixed-tumor-chondroid-syringoma-of-the-scapula-treated-with-staged-margin-controlled-excision
#5
Karan Lal, Travis J Morrell, Michael Cunningham, Patrick OʼDonnell, Nikki A Levin, Kristine M Cornejo
Cutaneous mixed tumor (chondroid syringoma) is the cutaneous counterpart of pleomorphic adenoma of salivary glands, comprised of both epithelial and mesenchymal components. Malignant transformation is exceptionally rare, with only a few cases reported. We report a case of a malignant cutaneous mixed tumor in an 86-year-old white man who presented with a pink indurated plaque on his left scapula. He had a history of nonmelanoma skin cancers, a stage IB malignant melanoma of a lower extremity and Gleason 4 + 3 prostate cancer treated with brachytherapy, external beam irradiation, and bicalutamide...
March 6, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29532344/the-negative-impact-of-body-mass-index-on-the-tumor-microenvironment-in-colon-cancer-results-of-a-prospective-trial
#6
Devin C Flaherty, John R Jalas, Myung S Sim, Alexander Stojadinovic, Mladjan Protic, Delphine J Lee, Anton J Bilchik
BACKGROUND: The association between tumor mismatch repair status and obesity in colon cancer is not well understood. The authors of this study hypothesized that mismatch repair deficiency in colon cancer may be associated with a lower Body Mass Index (BMI) and improved patient outcome due to an enhanced tumor immune microenvironment. METHODS: For this study, 70 patients were randomly selected from a prospective trial evaluating nodal ultrastaging for colon cancer...
March 12, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29503937/malignant-solitary-fibrous-tumor-of-the-orbit-spectrum-of-histologic-features
#7
Lilangi S Ediriwickrema, Michael Burnstine, Maria S Saber, Narsing Rao
Purpose: Primary malignant solitary fibrous tumor (SFT) of the orbit is a rare spindle cell neoplasm that requires excisional biopsy for histopathological diagnosis. We present a clinical case using contemporary immunohistochemical stains, report on the latest World Health Organization classification, and provide a review of the literature. Observations: Report of a single case of a 65 year old male who presented with right-sided proptosis, limited adduction, ptosis, lateral globe displacement, and cheek festooning...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29486992/combined-asrgl1-and-p53-immunohistochemistry-as-an-independent-predictor-of-survival-in-endometrioid-endometrial-carcinoma
#8
Jutta Huvila, Teemu D Laajala, Per-Henrik Edqvist, Adil Mardinoglu, Lauri Talve, Fredrik Pontén, Seija Grénman, Olli Carpén, Tero Aittokallio, Annika Auranen
OBJECTIVE: In clinical practise, prognostication of endometrial cancer is based on clinicopathological risk factors. The use of immunohistochemistry-based markers as prognostic tools is generally not recommended and a systematic analysis of their utility as a panel is lacking. We evaluated whether an immunohistochemical marker panel could reliably assess endometrioid endometrial cancer (EEC) outcome independent of clinicopathological information. METHODS: A cohort of 306 EEC specimens was profiled using tissue microarray (TMA)...
February 24, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29469188/indeterminate-cell-histiocytosis-in-a-chinese-patient-with-florid-and-extensive-nodular-lesions-and-mixed-intermediate-cell-and-macrophage-monocyte-bilineage
#9
Qiping Chen, Joyce Siong-See Lee, Weiting Michelle Liang, Mei Fung Chan, Ramón M Pujol, Requena Luis, Suat Hoon Tan
Indeterminate cell histiocytosis (ICH) is an extremely rare cutaneous neoplastic disorder. It has the immunophenotypic features of both Langerhans and non-Langerhans cell histiocytosis. We report here a case of a healthy young Chinese woman who presented with disfiguring thick, infiltrated cutaneous nodules on the face, trunk and extremities which appeared progressively over a period of 4 years. No systemic involvement has been detected so far. Results of a skin biopsy showed diffuse dermal infiltration of histiocytoid cells with indented nuclei and positive staining for S100 and CD1a and negativity for CD207 (langerin)...
February 22, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29467336/frameshift-events-predict-anti-pd-1-l1-response-in-head-and-neck-cancer
#10
Glenn J Hanna, Patrick Lizotte, Megan Cavanaugh, Frank C Kuo, Priyanka Shivdasani, Alexander Frieden, Nicole G Chau, Jonathan D Schoenfeld, Jochen H Lorch, Ravindra Uppaluri, Laura E MacConaill, Robert I Haddad
Programmed cell death protein 1 (PD-1) inhibitors have efficacy in treating squamous cell carcinoma of the head and neck (SCCHN), but objective response rates are low. PD-1 ligand (PD-L1) expression alone is not considered a robust predictor of response and additional biomarkers are needed. This 3-year observational cohort followed 126 SCCHN patients treated with anti-PD-1/L1 therapy. Prior to treatment, 81 (64%) had targeted massively parallel tumor sequencing. Of these, 42 (52%) underwent fluorescence-activated cell sorting and PD-L1 immunohistochemistry for tumor immunoprofiling...
February 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29449194/prostaglandin-d2-receptor-dp1-antibodies-predict-vaccine-induced-and-spontaneous-narcolepsy-type-1-large-scale-study-of-antibody-profiling
#11
Helle Sadam, Arno Pihlak, Anri Kivil, Susan Pihelgas, Mariliis Jaago, Priit Adler, Jaak Vilo, Olli Vapalahti, Toomas Neuman, Dan Lindholm, Markku Partinen, Antti Vaheri, Kaia Palm
BACKGROUND: Neuropathological findings support an autoimmune etiology as an underlying factor for loss of orexin-producing neurons in spontaneous narcolepsy type 1 (narcolepsy with cataplexy; sNT1) as well as in Pandemrix influenza vaccine-induced narcolepsy type 1 (Pdmx-NT1). The precise molecular target or antigens for the immune response have, however, remained elusive. METHODS: Here we have performed a comprehensive antigenic repertoire analysis of sera using the next-generation phage display method - mimotope variation analysis (MVA)...
February 2, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29414392/spatial-distribution-of-osteopontin-cd44v6-and-podoplanin-in-the-lining-epithelium-of-odontogenic-keratocyst-and-their-biological-relevance
#12
Khamisah Awang Kechik, Chong Huat Siar
BACKGROUND AND AIMS: The odontogenic keratocyst (OKC) remains the most challenging jaw cyst to treat because of its locally-aggressive behaviour and high recurrence potential. Emerging evidence suggests that osteopontin, its receptors CD44v6 and integrin αv, and podoplanin, have a role in the local invasiveness of this cyst. However the spatial distribution characteristics of these pro-invasive markers in the lining epithelium of OKC, and their association with the clinicopathologic parameters of OKC are largely unexplored...
February 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29406432/pseudomyogenic-hemangioendothelioma-case-report-and-review-of-the-literature
#13
Emily Raftopoulos, Michael Royer, Mildred Warren, Jin Zhao, Walter Rush
Pseudomyogenic hemangioendothelioma (PHE; epithelioid sarcoma-like hemangioendothelioma) is a rare entity, with 129 reported cases. It is a rarely metastasizing, low-grade vascular tumor that can histologically mimic epithelioid sarcoma and often presents as multiple discontinuous nodules in the extremities. PHEs characteristically and consistently show immunoreactivity for cytokeratins and endothelial markers. We present a case in the thigh of a 65-year-old-man with a 3-month history of painful lesions in the dermis and review the published literature...
February 2, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29333007/utility-of-cluster-of-differentiation-5-and-cluster-of-differentiation-117-immunoprofile-in-distinguishing-thymic-carcinoma-from-pulmonary-squamous-cell-carcinoma-a-study-on-1800-nonsmall-cell-lung-cancer-cases
#14
Vidya Jha, Preeti Sharma, Ashish Kumar Mandal
Background: Mediastinum harbors a mixed bag of neoplastic lesions with varied therapeutic and prognostic implications. Distinguishing pulmonary squamous cell carcinoma from thymic carcinoma is a challenging task owing to rather nonspecific clinicoradiological features and a considerable overlap in histomorphological features. Thus, we evaluated the diagnostic utility of cluster of differentiation 5 (CD5) and CD117 immunohistochemical markers in distinguishing these tumors. Materials and Methods: The archives of department of histopathology were retrospectively reviewed from June 2012 to May 2016...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29319188/immunoprofile-of-%C3%AE-gal-and-b-antigen-specific-responses-differentiates-red-meat-allergic-patients-from-healthy-individuals
#15
D Apostolovic, R Rodrigues, P Thomas, M Starkhammar, C Hamsten, M van Hage
BACKGROUND: The galactose-α-1,3-galactose (α-Gal) epitope is involved in red meat allergy. As α-Gal is structurally similar to the blood group B-antigen, we explored the relationship between the immune responses to α-Gal- and the B-antigen in red meat-allergic patients compared to healthy A/O or B blood donors. METHODS: Sera from 51 red meat-allergic patients IgE-positive to α-Gal and 102 healthy blood donors (51 blood group A/O; 51 blood group B) were included...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29309308/novel-ewsr1-smad3-gene-fusions-in-a-group-of-acral-fibroblastic-spindle-cell-neoplasms
#16
Yu-Chien Kao, Uta Flucke, Astrid Eijkelenboom, Lei Zhang, Yun-Shao Sung, Albert J H Suurmeijer, Cristina R Antonescu
Benign/low-grade fibroblastic tumors encompass a broad spectrum of tumors with different morphologies and molecular genetic abnormalities. However, despite significant progress in recent genomic characterization, there are still tumors in this histologic spectrum that are difficult to classify, lacking known molecular characteristics. Triggered by a challenging congenital spindle cell neoplasm arising in the heel of a 1-year-old boy, we applied RNA sequencing for genetic discovery and identified a novel EWSR1-SMAD3 gene fusion...
April 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29309307/a-distinct-malignant-epithelioid-neoplasm-with-gli1-gene-rearrangements-frequent-s100-protein-expression-and-metastatic-potential-expanding-the-spectrum-of-pathologic-entities-with-actb-malat1-ptch1-gli1-fusions
#17
Cristina R Antonescu, Narasimhan P Agaram, Yun-Shao Sung, Lei Zhang, David Swanson, Brendan C Dickson
ACTB-GLI1 fusions have been reported as the pathognomonic genetic abnormality defining an unusual subset of actin-positive, perivascular myoid tumors, known as "pericytoma with the t(7;12) translocation." In addition, GLI1 oncogenic activation through a related MALAT1-GLI1 gene fusion has been recently reported in 2 unrelated gastric tumors, namely plexiform fibromyxoma and gastroblastoma. Triggered by unexpected targeted RNA-sequencing results detecting GLI1-related fusions in a group of malignant neoplasms with round to epithelioid morphology, and frequently strong S100 protein immunoreactivity, we investigated their clinicopathologic features in relation to other known pathologic entities sharing similar genetics...
April 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29300189/bcor-ccnb3-fusion-positive-sarcomas-a-clinicopathologic-and-molecular-analysis-of-36-cases-with-comparison-to-morphologic-spectrum-and-clinical-behavior-of-other-round-cell-sarcomas
#18
Yu-Chien Kao, Adepitan A Owosho, Yun-Shao Sung, Lei Zhang, Yumi Fujisawa, Jen-Chieh Lee, Leonard Wexler, Pedram Argani, David Swanson, Brendan C Dickson, Christopher D M Fletcher, Cristina R Antonescu
BCOR-CCNB3 sarcoma (BCS) is a recently defined genetic entity among undifferentiated round cell sarcomas, which was initially classified as and treated similarly to the Ewing sarcoma (ES) family of tumors. In contrast to ES, BCS shows consistent BCOR overexpression, and preliminary evidence suggests that these tumors share morphologic features with other tumors harboring BCOR genetic alterations, including BCOR internal tandem duplication (ITD) and BCOR-MAML3. To further investigate the pathologic features, clinical behavior, and their relationship to other round cell sarcomas, we collected 36 molecularly confirmed BCSs for a detailed histologic and immunohistochemical analysis...
October 25, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29250492/transcriptional-immunoprofiling-at-the-tick-virus-host-interface-during-early-stages-of-tick-borne-encephalitis-virus-transmission
#19
Saravanan Thangamani, Meghan E Hermance, Rodrigo I Santos, Mirko Slovak, Dar Heinze, Steven G Widen, Maria Kazimirova
Emerging and re-emerging diseases transmitted by blood feeding arthropods are significant global public health problems. Ticks transmit the greatest variety of pathogenic microorganisms of any blood feeding arthropod. Infectious agents transmitted by ticks are delivered to the vertebrate host together with saliva at the bite site. Tick salivary glands produce complex cocktails of bioactive molecules that facilitate blood feeding and pathogen transmission by modulating host hemostasis, pain/itch responses, wound healing, and both innate and adaptive immunity...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29217416/identification-of-target-proteins-of-clinical-immunity-to-plasmodium-falciparum-in-a-region-of-low-malaria-transmission
#20
Hirokazu Sakamoto, Satoru Takeo, Eizo Takashima, Kazutoyo Miura, Bernard N Kanoi, Takamasa Kaneko, Eun-Taek Han, Mayumi Tachibana, Kazuhiro Matsuoka, Jetsumon Sattabongkot, Rachanee Udomsangpetch, Tomoko Ishino, Takafumi Tsuboi
The target molecules of antibodies against falciparum malaria remain largely unknown. Recently we have identified multiple proteins as targets of immunity against Plasmodium falciparum using African serum samples. To investigate whether potential targets of clinical immunity differ with transmission intensity, we assessed immune responses in residents of low malaria transmission region in Thailand. Malaria asymptomatic volunteers (Asy: n=19) and symptomatic patients (Sym: n=21) were enrolled into the study...
April 2018: Parasitology International
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