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https://www.readbyqxmd.com/read/29792307/putative-vaccine-candidates-and-drug-targets-identified-by-reverse-vaccinology-and-subtractive-genomics-approaches-to-control-haemophilus-ducreyi-the-causative-agent-of-chancroid
#1
Alissa de Sarom, Arun Kumar Jaiswal, Sandeep Tiwari, Letícia de Castro Oliveira, Debmalya Barh, Vasco Azevedo, Carlo Jose Oliveira, Siomar de Castro Soares
Chancroid is a sexually transmitted infection (STI) caused by the Gram-negative bacterium Haemophilus ducreyi The control of chancroid is difficult and the only current available treatment is antibiotic therapy; however, antibiotic resistance has been reported in endemic areas. Owing to recent outbreaks of STIs worldwide, it is important to keep searching for new treatment strategies and preventive measures. Here, we applied reverse vaccinology and subtractive genomic approaches for the in silico prediction of potential vaccine and drug targets against 28 strains of H...
May 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29790254/chemsex-and-new-hiv-diagnosis-in-gay-bisexual-and-other-men-who-have-sex-with-men-attending-sexual-health-clinics
#2
M Pakianathan, W Whittaker, M J Lee, J Avery, S Green, B Nathan, A Hegazi
OBJECTIVES: The aim of the study was to analyse associations between chemsex and new HIV and sexually transmitted infection (STI) diagnoses among gay, bisexual and other men who have sex with men (GBMSM) accessing sexual health clinics. METHODS: A retrospective case note review was carried out for all GBMSM attending two London sexual health clinics between 1 June 2014 and 31 July 2015. RESULTS: Chemsex status was documented for 1734 of 1840 patients...
May 22, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29788827/video-based-education-versus-nurse-led-education-for-partner-notification-in-thai-women-with-sexually-transmitted-infections-a-randomized-controlled-trial
#3
Chenchit Chayachinda, Chanakarn Kerdklinhom, Suphaphon Tachawatcharapunya, Nattha Saisaveoy
Health education on sexually transmitted infections (STIs), condom use, and partner notification (PN) is required to increase partner evaluation/treatment (PET) rate. To examine this issue, a randomized controlled trial comparing video-based and nurse-led education in women diagnosed with their first STI at the Siriraj Female STI clinic was conducted from March 2015 to March 2017. PN was assessed at two weeks and PET was done at four weeks. Of 330 patients, 225 were included in the analysis (N = 113 and N = 112 for video-based and nurse-led groups, respectively)...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29786768/risk-prediction-score-for-hiv-infection-development-and-internal-validation-with-cross-sectional-data-from-men-who-have-sex-with-men-in-china
#4
Lu Yin, Yuejuan Zhao, Meridith Blevins Peratikos, Liang Song, Xiangjun Zhang, Ruolei Xin, Zheya Sun, Yunan Xu, Li Zhang, Yifei Hu, Chun Hao, Yuhua Ruan, Yiming Shao, Sten H Vermund, Han-Zhu Qian
Receptive anal intercourse, multiple partners, condomless sex, sexually transmitted infections (STIs), and drug/alcohol addiction are familiar factors that correlate with increased human immunodeficiency virus (HIV) risk among men who have sex with men (MSM). To improve estimation to HIV acquisition, we created a composite score using questions from routine survey of 3588 MSM in Beijing, China. The HIV prevalence was 13.4%. A risk scoring tool using penalized maximum likelihood multivariable logistic regression modeling was developed, deploying backward step-down variable selection to obtain a reduced-form model...
May 21, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29784080/how-can-university-sexual-health-promotion-events-reach-those-most-at-risk-a-cross-sectional-study
#5
Matthew E Dunn, Merryn McKinnon
Background: The rate of notifications of sexually transmissible infections (STIs) in Australians has increased dramatically, especially in those aged 16-30 years. This age bracket, typical of university students, is the most likely to report multiple sexual partners in the previous year. Individuals who have sex with multiple partners in a year have a significantly increased chance of contracting an STI, making them an important audience for sexual health promotion. This study aimed to determine how university sexual health promotion events can better reach this higher-risk subset of the population...
May 22, 2018: Sexual Health
https://www.readbyqxmd.com/read/29782302/reasons-for-not-using-condoms-among-heterosexual-men-in-belgrade-serbia
#6
Milan Bjekić, Sandra Sipetić-Grujičić, Hristina Vlajinac, Aleksandra Nikolić
Dear Editor, Proper and consistent use of male condoms can be a highly effective method of preventing the transmission of sexually transmitted infections (STIs) and HIV (1), but this method relies on men's willingness and ability to use condoms. In the United States of America, about 20% overall and less than 50% of adults with multiple partners used a condom at last intercourse (2). In Serbia in 2013 (3), 50.0% of women and 62.5% of men aged 15-49 who had more than one partner in the past year used a condom during their last intercourse...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782296/sexual-behaviors-attitudes-and-knowledge-about-sexually-transmitted-infections-a-cross-sectional-study-in-romania
#7
Alecsandra Iulia Grad, Simona Corina Senilă, Rodica Cosgarea, Alexandru Dumitru Tataru, Stefan Cristian Vesa, Mihaela Laura Vica, Horea Vladi Matei, Loredana Ungureanu
Sexually transmitted infections (STIs) are serious public health problems. Little is known about sex knowledge, attitudes, and sexual behaviors among young adults in Romania; an effective preventive campaigns should be based on an appropriate understanding of these factors. The aim of the present study was to obtain data about sexual behavior, attitudes, and knowledge about STIs among university students aged 18-25 in Romania. 3872 persons completed an internet-based questionnaire, advertised on Facebook, regarding sexual behavior, attitudes, and knowledge about STIs from January 28 to February 28, 2016...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29779513/common-sexually-transmitted-infections-in-women
#8
REVIEW
Ashley L Hodges, Aimee Chism Holland
The spread of sexually transmitted infections (STIs) remains a significant public health issue in the United States. Social, economic, and behavioral implications affecting the spread of STIs have been identified. The most important social factor in the United States is the stigma associated with discussing sex and STI screening. In this article, specific recommendations for women are included regarding screening, diagnosing, and treating common vaginal and cervical infections. Screening women for infections of the vagina and cervix is essential because untreated infections may result in complications that have current and long-term health consequences and impact quality of life...
June 2018: Nursing Clinics of North America
https://www.readbyqxmd.com/read/29778101/prevalence-of-self-reported-symptoms-of-sexually-transmitted-infections-knowledge-and-sexual-behaviour-among-youth-in-semi-rural-tanzania-in-the-period-of-adolescent-friendly-health-services-strategy-implementation
#9
Ramadhani Abdul, Annette A M Gerritsen, Mary Mwangome, Eveline Geubbels
BACKGROUND: Global evidence shows that sexually transmitted infections (STIs) prevalence and sexual risk behaviours are high among youth, and knowledge about STIs is low. In Tanzania, there is limited recent evidence regarding these issues. The aim of this study was to describe the health seeking behaviour of youth reporting STI symptoms in semi-rural Tanzania and to evaluate the association of socio-demographic characteristics, STI knowledge and sexual risk behaviour with STI symptom reporting...
May 19, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29776395/linking-young-men-who-have-sex-with-men-ymsm-to-sti-physicians-a-nationwide-cross-sectional-survey-in-china
#10
Bolin Cao, Peipei Zhao, Cedric Bien, Stephen Pan, Weiming Tang, Julia Watson, Guodong Mi, Yi Ding, Zhenzhou Luo, Joseph D Tucker
BACKGROUND: Many young men who have sex with men (YMSM) are reluctant to seek health services and trust local physicians. Online information seeking may encourage YMSM to identify and see trustworthy physicians, obtain sexual health services, and obtain testing for sexually transmitted infections (STIs). This study examined online STI information seeking behaviors among Chinese YMSM and its association with offline physician visits. METHODS: We conducted a nationwide online survey among YMSM through WeChat, the largest social media platform in China...
May 18, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29770100/lymphogranuloma-venereum-in-quebec-re-emergence-among-men-who-have-sex-with-men
#11
C A Boutin, S Venne, M Fiset, C Fortin, D Murphy, A Severini, C Martineau, J Longtin, A C Labbé
Background: Lymphogranuloma venereum (LGV) is a sexually transmitted infection (STI) caused by Chlamydia trachomatis genotypes L1 , L2 and L3 . This LGV is associated with significant morbidity and increased risk of HIV transmission. While fewer than two cases per year were reported in Quebec before 2005, LGV emerged in 2005-2006 with 69 cases, followed by a period of low incidence (2007-2012), and subsequent re-emergence since 2013. Objectives: To describe the incidence of LGV in Quebec and the characteristics of the affected population, including demographics and risk factors, clinical manifestations, laboratory tests, treatments and reinfection rates...
February 1, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29770078/evaluating-the-timeliness-of-reporting-in-a-first-nations-communicable-diseases-program
#12
A Lam, S Woods, N Ndubuka
Background: Timely reporting of communicable diseases is necessary to enable a prompt response to mitigate and control outbreaks. This is especially true among First Nations communities due to a number of factors, including unique social determinants of health, which can contribute to rapid disease transmission. Objective: To assess the timeliness of reporting for 12 notifiable communicable diseases in the Northern Inter-Tribal Health Authority, which includes 33 First Nations on-reserve communities in Northern Saskatchewan, Canada, and to assess whether there were differences in reporting times depending on degree of remoteness of community, season or year...
June 1, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29768621/sexual-violence-against-women-and-care-in-the-health-sector-in-santa-catarina-brazil
#13
Carmem Regina Delziovo, Elza Berger Salema Coelho, Eleonora d'Orsi, Sheila Rubia Lindner
This is a study on sexual violence against women in the Brazilian State of Santa Catarina notified to the Notifiable Diseases Information System (SINAN) in the period 20082013. It aimed to estimate pregnancy and sexually transmitted infections (STIs) resulting from sexual violence and to test the association between pregnancy, STIs and care provided in health services. In total, 1,230 pregnancy notifications and 1.316 STI notifications were analyzed. Variables were age, schooling, time to receive care, STI prophylaxis, emergency contraception, number of perpetrators and recurrent violence, which were analyzed using proportions and 95% confidence intervals...
May 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29767781/adolescent-condom-use-and-connectivity-in-the-social-planful-brain
#14
Justin D Caouette, Karen A Hudson, Angela D Bryan, Sarah W Feldstein Ewing
Objective: To reduce rates of sexually transmitted infections (STIs) and unwanted pregnancy among adolescents, it is critical to investigate brain connectivity that may underlie adolescents' sexual health decision-making in the context of intercourse. This study explored relationships between adolescent condom use frequency and the brain's resting-state functional connectivity, to identify differential patterns of social-affective processing among sexually active youth. Methods: In this study, N = 143 sexually active adolescents (68...
May 14, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29758049/user-evaluations-offer-promise-for-pod-intravaginal-ring-as-a-drug-delivery-platform-a-mixed-methods-study-of-acceptability-and-use-experiences
#15
Kate M Guthrie, Rochelle K Rosen, Sara E Vargas, Melissa L Getz, Lauren Dawson, Melissa Guillen, Jaime J Ramirez, Marc M Baum, Kathleen L Vincent
BACKGROUND: Effective HIV prevention requires efficient delivery of safe and efficacious drugs and optimization of user adherence. The user's experiences with the drug, delivery system, and use parameters are critical to product acceptability and adherence. Prevention product developers have the opportunity to directly control a drug delivery system and its impact on acceptability and adherence, as well as product efficacy. Involvement of potential users during preclinical design and development can facilitate this process...
2018: PloS One
https://www.readbyqxmd.com/read/29746181/examining-heterosexual-women-s-anal-sexual-health-knowledge-and-product-use
#16
Kimberly R McBride
Prevalence rates indicate that receptive anal sex is increasingly part of heterosexual women's sexual repertoire. However, there is a body of literature linking this behavior to risk for adverse sexual health outcomes. Women's anal sexual health knowledge and awareness of behaviors associated with elevated risk have received less attention in the research literature. The aim of the current study was to examine anal sexual health knowledge and product use among heterosexual women aged 18 to 30 years. A total of 33 self-identified heterosexual women recruited from the general population participated in one of six focus groups...
May 10, 2018: Journal of Sex Research
https://www.readbyqxmd.com/read/29744768/symptom-based-versus-laboratory-based-diagnosis-of-five-sexually-transmitted-infections-in-female-sex-workers-in-iran
#17
Armita Shahesmaeili, Mohammad Karamouzian, Mostafa Shokoohi, Kianoush Kamali, Noushin Fahimfar, Seyed Alireza Nadji, Hamid Sharifi, Ali Akbar Haghdoost, Ali Mirzazadeh
Among 1337 Iranian adult female sex workers in 2015, we assessed the diagnostic value of 4 self-reported sexually transmitted infection (STIs) symptoms for detecting laboratory-confirmed gonorrhea, chlamydia, trichomoniasis, human papillomavirus (HPV), and syphilis. While 37.7% reported vaginal discharge (VD), 25.9% reported pain or burning (P/B), 3.0% reported genital ulcers (GU), and 1.4% reported genital warts (GW), the prevalence of laboratory-confirmed syphilis, gonorrhea, chlamydia, trichomoniasis, and HPV was 0...
May 9, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29743004/pilot-testing-fostering-open-expression-among-youth-foxy-an-arts-based-hiv-sti-prevention-approach-for-adolescent-women-in-the-northwest-territories-canada
#18
Candice L Lys, Carmen H Logie, Moses Okumu
Fostering Open eXpression among Youth (FOXY) is an arts-based HIV prevention program developed by Northern Canadians to address sexual health, HIV, sexually transmitted infections (STIs), sexuality, and healthy relationships among Northern and Indigenous youth in Canada. We conducted a pilot study with Indigenous and Northern young women aged 13-17 years from 17 communities in the Northwest Territories to evaluate whether, in comparison to pre-intervention, FOXY participants demonstrated increased knowledge of STIs, increased safer sex self-efficacy, and increased resilience...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29741665/evaluation-of-prep-eligibility-criteria-using-sexually-transmissible-infections-as-hiv-risk-markers-at-enrolment-in-prepx-a-large-australian-hiv-pre-exposure-prophylaxis-trial
#19
Vincent J Cornelisse, Christopher K Fairley, Mark Stoove, Jason Asselin, Eric P F Chow, Brian Price, Norman J Roth, Jeff Willcox, B K Tee, Matthew Penn, Christina C Chang, Judith Armishaw, George Forgan-Smith, Edwina J Wright
Background: The PrEPX trial provided HIV pre-exposure prophylaxis (PrEP) to 2600 people in Victoria, Australia. To determine participants' HIV risk, PrEPX used six eligibility criteria derived from the Australian PrEP guidelines, based on the CDC PrEP guidelines. Participants who fulfilled no eligibility criteria could be enrolled if clinically assessed to need PrEP. This study evaluated whether PREPX eligibility criteria correlated with biological HIV risk markers, namely syphilis, anorectal chlamydia or anorectal gonorrhoea (STIs)...
May 7, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29734660/syzygium-cordatum-hochst-ex-krauss-an-overview-of-its-ethnobotany-phytochemistry-and-pharmacological-properties
#20
REVIEW
Alfred Maroyi
Syzygium cordatum is a valuable medicinal plant in the materia medica of east and southern Africa. The aim of this study was to review the botany, medicinal uses, phytochemistry and ethnopharmacological properties of S. cordatum . Relevant literature search was carried out using internet sources such as ACS, Web of Science, Wiley, SpringerLink, Scopus, Mendeley, Google Scholar, Pubmed, SciFinder, BioMed Central, Science Direct and Elsevier. Other literature sources were conference papers, book chapters, books, theses and websites...
May 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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