keyword
MENU ▼
Read by QxMD icon Read
search

Prenylation

keyword
https://www.readbyqxmd.com/read/29782651/pharmacokinetic-and-metabolism-studies-of-bavachinin-through-ultra-high-performance-liquid-chromatography-coupled-with-electrospray-ionization-tandem-mass-spectrometry
#1
Jun Qian, Fan Xie, Yanhong Shi, Jinhang Li, Liuqiang Zhang, Yiming Li, Fujiang Guo, Rui Wang
Bavachinin (BVC), one of the main bioactive prenylated flavonoids derived from Psoralea corylifolia Linn, has a wide variety of pharmacological effects, such as antiangiogenic, antitumour, antiallergic, anti-inflammatory, and antibacterial activities, especially as a pan-peroxisome proliferator-activated receptors (PPARs) agonist. A rapid and sensitive method for quantifying BVC in rat plasma was developed and validated through ultra-high-performance liquid chromatography coupled with electrospray-ionization tandem mass spectrometry...
May 21, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29778569/mevalonate-pathway-blockage-enhances-the-efficacy-of-mtor-inhibitors-with-the-activation-of-retinoblastoma-protein-in-renal-cell-carcinoma
#2
Nobuhisa Hagiwara, Motoki Watanabe, Mahiro Iizuka-Ohashi, Isao Yokota, Seijiro Toriyama, Mamiko Sukeno, Mitsuhiro Tomosugi, Yoshihiro Sowa, Fumiya Hongo, Kazuya Mikami, Jintetsu Soh, Akira Fujito, Hiroaki Miyashita, Yukako Morioka, Tsuneharu Miki, Osamu Ukimura, Toshiyuki Sakai
Renal cell carcinoma (RCC) is the most common malignancy of kidney and remains largely intractable once it recurs after resection. mTOR inhibitors have been one of the mainstays used against recurrent RCC; however, there has been a major problem of the resistance to mTOR inhibitors, and thus new combination treatments with mTOR inhibitors are required. We here retrospectively showed that regular use of antilipidemic drug statins could provide a longer progression free survival (PFS) in RCC patients prescribed with an mTOR inhibitor everolimus than without statins (median PFS, 7...
May 17, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29777701/ropivacaine-inhibits-the-migration-of-esophageal-cancer-cells-via-sodium-channel-independent-but-prenylation-dependent-inhibition-of-rac1-jnk-paxillin-fak
#3
Yaqin Zhang, Xiaohong Peng, Qinghong Zheng
The direct anti-proliferative and pro-apoptotic effects of local anesthetics have been well documented in various cancers. However, whether local anesthetics affect cancer metastasis and their underlying molecular mechanisms are not well understood. In this work, we show that ropivacaine at the clinically relevant concentration significantly inhibits esophageal cancer cell migration. Interestingly, ropivacaine at the same concentration does not display inhibitory effects on esophageal cancer cell growth and survival...
May 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29775541/molecular-characterization-and-bioactivity-of-coumarin-derivatives-from-the-fruits-of-cucumis-bisexualis
#4
Qin-Ge Ma, Rong-Rui Wei, Ming Yang, Xiao-Ying Huang, Fang Wang, Zhi-Pei Sang, Wen-Min Liu, Qing Yu
Cucumis bisexualis (Cucurbitaceae) is known as "mapao egg" or "muskmelon egg", which has been widely used as a wild melon in Chinese folk. Nine new coumarin derivatives (1-9), named 7-hydroxy-3-(4',6'-dihydroxy-5'-isopropyl-3'',3''-dimethyl-2H-chromen)-6-prenyl-2H-chromen-2-one (1), 7-hydroxy-3-(5'-prenyl-3'',3''-dimethyl-2H-chromen)-6-prenyl-2H-chromen-2-one (2), 3-(6'-hydroxy-5'-prenyl-3'',3''-dimethyl-2H-chromen)-6-prenyl-2H-chromen-2-one (3), 3-(5'-ethyl-3'',3''-dimethyl-2H-chromen)-6-prenyl-2H-chromen-2-one (4), 3-(4',6'-dihydroxy-5'-dimethylallyl-3'',3''-dimethyl-2H-chromen)-6-prenyl-2H-chromen-2-one (5), 3-[4',6'-dihydroxy-5'-(2-propenyl)-3'',3''-dimethyl-2H-chromen]-14,15-dimethyl-pyrano-chromen-2-one (6), 3-(6'-dihydroxy-5'-isopropanol-3'',3''-dimethyl-2H-chromen)-14,15-dimethyl-pyrano-chromen-2-one (7), 3-(5'-isopentenol-3'',3''-dimethyl-2H-chromen)-14,15-dimethyl-pyrano-chromen-2-one (8), 3-(4',6'-dihydroxy-5'-prenyl-3'',3''-dimethyl-2H-chromen)-14,15-dimethyl-pyrano-chromen-2-one (9), together with twelve known compounds (10-21), were isolated and identified by spectroscopic analysis and references from the active site (EtOAc soluble fraction) of the fruits of C...
May 18, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29772410/estrogenic-properties-of-coumarins-and-meroterpene-from-the-fruits-of-cullen-corylifolium-experimental-and-computational-studies
#5
Tiehua Zhang, Shuning Zhong, Ligang Hou, Tiezhu Li, XiaoJia Xing, Tianzhu Guan, Jie Zhang, Yongjun Wang
Coumarins and meroterpene from the fruits of Cullen corylifolium were evaluated for their ability to bind and activate human estrogen receptor α (hERα) by a combination of in vitro studies and molecular dynamics simulations. The recombinant hERα ligand binding domain (hERα-LBD) was produced in BL21 (DE3)pLysS and the fluorescence polarization (FP) assay was performed to determine the binding affinities of coumarins and meroterpene with receptor protein. These compounds displayed distinct binding potency toward hERα-LBD, generally increased with their increasing molecular length and Connolly solvent-excluded volume (CSEV)...
May 14, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29770114/extracts-of-artocarpus-communis-induce-mitochondria-associated-apoptosis-via-pro-oxidative-activity-in-human-glioblastoma-cells
#6
Chiang-Wen Lee, Lee-Fen Hsu, Ming-Hsueh Lee, I-Ta Lee, Ju-Fang Liu, Yao-Chang Chiang, Ming-Horng Tsai
Glioblastoma multiforme (GBM) is an extremely aggressive and devastating malignant tumor in the central nervous system. Its incidence is increasing and the prognosis is poor. Artocarpin is a natural prenylated flavonoid with various anti-inflammatory and anti-tumor properties. Studies have shown that artocarpin is associated with cell death of primary glioblastoma cells. However, the in vivo effects and the cellular and molecular mechanisms modulating the anticancer activities of artocarpin remain unknown. In this study, we demonstrated that treating the glioblastoma cell lines U87 and U118 cells with artocarpin induced apoptosis...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29763460/lipophilic-statins-limit-cancer-cell-growth-and-survival-via-involvement-of-akt-signaling
#7
Colin H Beckwitt, Keisuke Shiraha, Alan Wells
The HMG-CoA reductase inhibitors, statins, have been used as lipid lowering drugs for decades and several epidemiological studies suggest statin usage correlates with a decreased incidence of cancer specific mortality in patients. However, the mechanism of this mortality benefit remains unclear. Here, we demonstrate that statin drug lipophilicity and affinity for its target enzyme, HMGCR, determine their growth suppressive potency against various tumor cell lines. The lipophilic atorvastatin decreases cancer cell proliferation and survival in vitro...
2018: PloS One
https://www.readbyqxmd.com/read/29760092/noncatalytic-chalcone-isomerase-fold-proteins-in-humulus-lupulus-are-auxiliary-components-in-prenylated-flavonoid-biosynthesis
#8
Zhaonan Ban, Hao Qin, Andrew J Mitchell, Baoxiu Liu, Fengxia Zhang, Jing-Ke Weng, Richard A Dixon, Guodong Wang
Xanthohumol (XN) and demethylxanthohumol (DMX) are specialized prenylated chalconoids with multiple pharmaceutical applications that accumulate to high levels in the glandular trichomes of hops ( Humulus lupulus L.). Although all structural enzymes in the XN pathway have been functionally identified, biochemical mechanisms underlying highly efficient production of XN have not been fully resolved. In this study, we characterized two noncatalytic chalcone isomerase (CHI)-like proteins (designated as HlCHIL1 and HlCHIL2) using engineered yeast harboring all genes required for DMX production...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29758494/uncovering-potential-anti-neuroinflammatory-components-of-modified-wuziyanzong-prescription-through-a-target-directed-molecular-docking-fingerprint-strategy
#9
Jinfeng Chen, Jinlong Wang, Yingyuan Lu, Shaoyang Zhao, Qian Yu, Xuemei Wang, Pengfei Tu, Kewu Zeng, Yong Jiang
Neuroinflammation is a main factor in the pathogenesis of neurodegenerative diseases, such as Alzheimer disease. Our previous studies indicated that the modified Wuziyanzong Prescription (MWP) can suppress neuroinflammatory responses via nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) signaling pathways. However, the anti-neuroinflammatory components of MWP remain unclear. Herein, a target-directed molecular docking fingerprint (TMDF) strategy, via integrating the chemical profiling and molecular docking approaches, was developed to identify the potential anti-neuroinflammatory components of MWP...
May 1, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29751080/prenylated-%C3%AE-diketones-two-new-additions-to-the-family-of-biologically-active-hypericum-perforatum-l-hypericaceae-secondary-metabolites
#10
Niko S Radulović, Marija S Genčić, Nikola M Stojanović, Pavle J Randjelović, Nicolas Baldovini, Vanya Kurteva
Two novel β-diketones, 2,6,9-trimethyl-8-decene-3,5-dione (A) and 3,7,10-trimethyl-9-undecene-4,6-dione (B), were identified from the renowned medicinal plant Hypericum perforatum L. The structures of β-diketones A and B were corroborated by syntheses (4 steps starting from methyl acetoacetate, overall yields 30% and 23%, respectively). In solution, these β-diketones predominantly exist as two rapidly interconverting β-keto-enol tautomers. The structures of A and B show some common fragments with the molecules of hyperforin and adhyperforin, respectively, the acknowledged multi-target secondary metabolites from St...
May 8, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29748388/the-kinetochore-proteins-cenp-e-and-cenp-f-directly-and-specifically-interact-with-distinct-bub-mitotic-checkpoint-ser-thr-kinases
#11
Giuseppe Ciossani, Katharina Overlack, Arsen Petrovic, Pim J Huis In 't Veld, Carolin Koerner, Sabine Wohlgemuth, Stefano Maffini, Andrea Musacchio
The segregation of chromosomes during cell division relies on the function of the kinetochores, protein complexes that physically connect chromosomes with microtubules of the spindle. The metazoan proteins, centromere protein E (CENP-E) and CENP-F, are components of a fibrous layer of mitotic kinetochores named the corona. Several of their features suggest that CENP-E and CENP-F are paralogs: they are very large (comprising approximately 2700 and 3200 residues, respectively), contain abundant predicted coiled-coil structures, are C-terminally prenylated, and are endowed with microtubule-binding sites at their termini...
May 10, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29747239/mir-4725-3p-targeting-stim1-signaling-is-involved-in-xanthohumol-inhibition-of-glioma-cell-invasion
#12
Kuo-Hao Ho, Cheng-Kuei Chang, Peng-Hsu Chen, Yu-Jia Wang, Wei-Chiao Chang, Ku-Chung Chen
Glioblastoma multiforme (GBM) is the most common brain tumor in adults. Due to its highly invasive nature, it is not easy to treat, resulting in high mortality rates. Stromal interacting molecule 1 (Stim1) plays important roles in regulating store-operated Ca2+ entry (SOCE), and controls invasion by cancer cells. However, the mechanisms and functions of Stim1 in glioma progression are still unclear. In this study, we investigated the effects of targeting Stim1 expression on glioma cell invasion. By analyzing profiles of GBM patients from RNA-sequencing data in The Cancer Genome Atlas (TCGA), higher expression levels of STIM1 were correlated with the poor survival...
May 10, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29746868/isoprenylcysteine-carboxylmethyltransferase-regulates-ovarian-cancer-cell-response-to-chemotherapy-and-ras-activation
#13
Qiong Liu, Jun Chen, Bingbing Fu, Jie Dai, Ying Zhao, Lin Lai
Inhibition of isoprenylcysteine carboxylmethyltransferase (Icmt), which catalyzes the final step of oncoproteins' prenylation, targets growth and survival of various cancers. In this work, we systematically studied the expression, functions and molecular signaling of Icmt in ovarian cancer. We show that the upregulation of Icmt expression is a common feature in patients with epithelial ovarian cancer regardless of age and disease stage. In line with the observations in ovarian cancer patients, a panel of epithelial ovarian cancer cell lines also demonstrates the significant increase on Icmt transcript and protein levels than normal ovarian epithelial cells...
May 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29738971/sophoflavanones-a-and-b-two-novel-prenylated-flavanones-from-the-roots-of-sophora-flavescens
#14
Hui Zhu, Ya-Nan Yang, Zi-Ming Feng, Jian-Shuang Jiang, Pei-Cheng Zhang
In our ongoing investigation of the bioactive compounds from the extract of the roots of Sophora flavescens, two novel prenylated flavanones, named sophoflavanones A (1) and B (2), each with an unusual pyran ring were isolated. Their structures, as well as their absolute configurations, were elucidated based on spectroscopic data including a comparison of their experimental and calculated electronic circular dichroism (ECD) spectra. Additionally, compounds 1 and 2 showed moderate antioxidant activities against Fe2+ /cysteine-induced toxicity at a concentration of 0...
April 26, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29721959/binary-function-of-arl3-gtp-revealed-by-gene-knockouts
#15
Christin Hanke-Gogokhia, Jeanne M Frederick, Houbin Zhang, Wolfgang Baehr
UNC119 and PDEδ are lipid-binding proteins and are thought to form diffusible complexes with transducin-α and prenylated OS proteins, respectively, to mediate their trafficking to photoreceptor outer segments. Here, we investigate mechanisms of trafficking which are controlled by Arf-like protein 3 (Arl3), a small GTPase. The activity of ARL3 is regulated by a GEF (ARL13b) and a GAP (RP2). In a mouse germline knockout of RP2, ARL3-GTP is abundant as its intrinsic GTPase activity is extremely low. High levels of ARL3-GTP impair binding and trafficking of cargo to the outer segment...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29718780/isoprenoids-and-protein-prenylation-implications-in-the-pathogenesis-and-therapeutic-intervention-of-alzheimer-s-disease
#16
Angela Jeong, Kiall Francis Suazo, W Gibson Wood, Mark D Distefano, Ling Li
The mevalonate-isoprenoid-cholesterol biosynthesis pathway plays a key role in human health and disease. The importance of this pathway is underscored by the discovery that two major isoprenoids, farnesyl and geranylgeranyl pyrophosphate, are required to modify an array of proteins through a process known as protein prenylation, catalyzed by prenyltransferases. The lipophilic prenyl group facilitates the anchoring of proteins in cell membranes, mediating protein-protein interactions and signal transduction...
June 2018: Critical Reviews in Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29715450/racking-up-ceramide-induced-islet-%C3%AE-cell-dysfunction
#17
REVIEW
Anjaneyulu Kowluru, Renu A Kowluru
The International Diabetes Federation predicts that by 2045 the number of individuals afflicted with diabetes will increase to 629 million. Furthermore, ∼352 million individuals with impaired glucose tolerance are at increased risk for developing diabetes. Several mechanisms have been proposed for the onset of metabolic dysfunction and demise of the islet β-cell leading to the pathogenesis of diabetes. It is widely accepted that the onset of type 2 diabetes is due to an intricate interplay between genetic expression of the disease and a multitude of factors including increased oxidative and endoplasmic reticulum stress consequential to glucolipotoxicity and inflammation...
April 28, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29710518/the-higher-osteoprotective-activity-of-psoralidin-in-vivo-than-coumestrol-is-attributed-by-its-presence-of-an-isopentenyl-group-and-through-activated-pi3k-akt-axis
#18
Yuankun Zhai, Qingfeng Wang, Yingying Li, Jiawei Cui, Kun Feng, Xijian Kong, Cory J Xian
Prenylation of bioactive natural compounds has been postulated to be able to enhance the utilization rate and affinity of the compounds with cell membranes, thus promote their bioactivities. Coumestrol, isolated from Medicago sativa, has been known as a phytoestrogen which has bone health benefits. In our previous work, psoralidin, a prenylated coumestrol, was proved to have a higher ability than coumestrol to promote bone formation and to attenuate resorption in vitro. However, it remains to be investigated whether psoralidin will have stronger bone health benefits than coumestrol...
April 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29707603/the-biological-activity-of-aav-vectors-for-choroideremia-gene-therapy-can-be-measured-by-in-vitro-prenylation-of-rab6a
#19
Maria I Patrício, Alun R Barnard, Christopher I Cox, Clare Blue, Robert E MacLaren
Choroideremia (CHM) is a rare, X-linked recessive retinal dystrophy caused by mutations in the CHM gene. CHM is ubiquitously expressed in human cells and encodes Rab escort protein 1 (REP1). REP1 plays a key role in intracellular trafficking through the prenylation of Rab GTPases, a reaction that can be reproduced in vitro . With recent advances in adeno-associated virus (AAV) gene therapy for CHM showing gene replacement to be a promising approach, an assay to assess the biological activity of the vectors is of the uttermost importance...
June 15, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29701961/post-translational-tyrosine-geranylation-in-cyanobactin-biosynthesis
#20
Maho Morita, Yue Hao, Jouni K Jokela, Debosmita Sardar, Zhenjian Lin, Kaarina Sivonen, Satish K Nair, Eric W Schmidt
Prenylation is a widespread modification that improves the biological activities of secondary metabolites. This reaction also represents a key modification step in biosyntheses of cyanobactins, a family of ribosomally synthesized and post-translationally modified peptides (RiPPs) produced by cyanobacteria. In cyanobactins, amino acids are commonly isoprenylated by ABBA prenyltransferases that use C5 donors. Notably, mass spectral analysis of piricyclamides from a fresh-water cyanobacterium suggested that they may instead have a C10 geranyl group...
May 1, 2018: Journal of the American Chemical Society
keyword
keyword
66832
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"