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c reactive protein in cardiac patients

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https://www.readbyqxmd.com/read/29439878/thickness-and-an-altered-mirna-expression-in-the-epicardial-adipose-tissue-is-associated-with-coronary-heart-disease-in-sudden-death-victims
#1
Josep Marí-Alexandre, Moises Barceló-Molina, Jorge Sanz-Sánchez, Pilar Molina, Jennifer Sancho, Yolanda Abellán, María Luisa Santaolaria-Ayora, Juan Giner, Luis Martínez-Dolz, Amparo Estelles, Aitana Braza-Boïls, Esther Zorio
INTRODUCTION AND OBJECTIVES: An increased epicardial adipose tissue (EAT) thickness has become a new risk factor for coronary heart disease (CHD). We aimed to study the role of EAT dysfunction as a CHD marker by focusing on its thickness and microRNA (miRNA) expression profile, and the potential factors possibly influencing them. METHODS: One hundred and fifty-five CHD sudden cardiac death victims and 84 non-CHD-sudden death controls were prospectively enrolled at autopsy...
February 10, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29439446/the-t2238c-human-atrial-natriuretic-peptide-molecular-variant-and-the-risk-of-cardiovascular-diseases
#2
REVIEW
Speranza Rubattu, Sebastiano Sciarretta, Simona Marchitti, Franca Bianchi, Maurizio Forte, Massimo Volpe
Atrial natriuretic peptide (ANP) is a cardiac hormone which plays important functions to maintain cardio-renal homeostasis. The peptide structure is highly conserved among species. However, a few gene variants are known to fall within the human ANP gene. The variant rs5065 (T2238C) exerts the most substantial effects. The T to C transition at the 2238 position of the gene (13-23% allele frequency in the general population) leads to the production of a 30-, instead of 28-, amino-acid-long α-carboxy-terminal peptide...
February 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29428559/elevated-il-27-in-patients-with-acute-coronary-syndrome-is-associated-with-adverse-ventricular-remodeling-and-increased-risk-of-recurrent-myocardial-infarction-and-cardiovascular-death
#3
Helena Grufman, Troels Yndigegn, Isabel Gonçalves, Jan Nilsson, Alexandru Schiopu
BACKGROUND AND AIMS: IL-27 is an immunoregulatory cytokine belonging to the IL-6/IL-12 family that was found to be elevated in acute coronary syndrome (ACS) patients. We investigated whether IL-27 is related to post-ischemic cardiac remodeling and long-term prognosis in this patient group. METHODS: We included 524 ACS patients, defined as acute myocardial infarction (AMI) or unstable angina (UA). A subgroup of 107 patients donated blood samples 6 weeks after the index event, and underwent a follow-up echocardiographical examination at 1 year...
February 7, 2018: Cytokine
https://www.readbyqxmd.com/read/29428236/liver-fibrosis-marker-7s-domain-of-collagen-type-iv-in-patients-with-pre-capillary-pulmonary-hypertension
#4
Akiomi Yoshihisa, Yusuke Kimishima, Takatoyo Kiko, Yu Sato, Shunsuke Watanabe, Yuki Kanno, Satoshi Abe, Makiko Miyata-Tatsumi, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Takafumi Ishida, Yasuchika Takeishi
BACKGROUND: Pulmonary hypertension (PH) causes right ventricular dysfunction and central venous congestion, and may lead to congestive hepatopathy. The serum 7S domain of collagen type IV (P4NP 7S) is an established marker of liver fibrosis in chronic liver disease. We aimed to determine whether P4NP 7S is related to hemodynamic parameters, and assessed the potential values of P4NP 7S to predict mortality. METHODS: Consecutive 76 pre-capillary PH patients were divided into tertiles based on their serum P4NP 7S levels...
February 7, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29411336/central-sleep-apnea-with-cheyne-stokes-breathing-in-heart-failure-from-research-to-clinical-practice-and-beyond
#5
K Terziyski, A Draganova
Characterized by periodic crescendo-decrescendo pattern of breathing alternating with central apneas, Central sleep apnea (CSA) with Cheyne-Stokes Breathing represents a highly prevalent, yet underdiagnosed comorbidity in chronic heart failure (CHF). A diverse body of evidence demonstrates increased morbidity and mortality in the presence of CSB. CSB has been described in both CHF patients with preserved and reduced ejection fraction, regardless of drug treatment. Risk factors for CSB are older age, male gender, high BMI, atrial fibrillation and hypocapnia...
February 7, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29399761/kinetics-of-common-inflammatory-biomarkers-in-postoperative-course-after-congenital-heart-defects-procedures-with-extracorporeal-circulation-in-children
#6
Ireneusz Haponiuk, Radosław Jaworski, Konrad Paczkowski, Maciej Chojnicki, Mariusz Steffens, Aneta Szofer-Sendrowska, Katarzyna Gierat-Haponiuk, Ewelina Kwaśniak, Marta Paśko-Majewska, Katarzyna Leszczyńska, Jacek Zieliński, Wiktor Szymanowicz
BACKGROUND: The extracorporeal circulation is associated with systemic inflammatory response syndrome. Therefore, the diagnosis of infection should be differenced from typical postoperative course. AIM: Evaluation of kinetics of inflammatory biomarkers in children in the first days after cardiac surgery with extracorporeal circulation. METHODS: Prospective data collection from 51 consecutive children referred for surgical treatment [the Institution], between February 2015 and August 2015...
February 5, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29398998/postoperative-myocardial-injury-and-inflammation-is-not-blunted-by-a-trial-of-atorvastatin-in-orthopedic-surgery-patients
#7
Anne R Bass, Jackie D Szymonifka, Matthew T Rondina, Margaret Bogardus, Mitchell G Scott, Scott C Woller, Scott M Stevens, Charles Eby, Kerri Merritt, Alejandro Gonzalez Della Valle, Gerard Moskowitz, Eva Flores, Brian F Gage
Background: Orthopedic patients are at risk for adverse postoperative cardiovascular outcomes. Questions/Purposes: This pilot randomized controlled trial (RCT) of atorvastatin vs. placebo in orthopedic surgery patients was performed in order to assess: (1) the prevalence of perioperative myocardial injury; (2) the effect of atorvastatin on perioperative inflammation; and (3) the feasibility of performing a large RCT of statin therapy in orthopedic patients. Methods: Hip fracture (hip Fx) and total hip and knee replacement (THR and TKR) patients were randomized 1:1 to atorvastatin 40 mg daily vs...
February 2018: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/29397446/marseille-scoring-system-for-empiric-treatment-of-infective-endocarditis
#8
Frédérique Gouriet, Hervé Tissot-Dupont, Jean-Paul Casalta, Sandrine Hubert, Pierre-Edouard Fournier, Sophie Edouard, Alexis Theron, Hubert Lepidi, Dominique Grisoli, Gilbert Habib, Didier Raoult
Despite advances in medical, surgical, and critical care, infective endocarditis (IE) remains associated with considerable morbidity and mortality. We evaluated the performance of the Marseille score, including clinical data and biological tests obtained within 2 h, to identify patients at high risk of IE in order to initiate early antimicrobial treatment. This was secondarily confirmed using modified ESC criteria combined with molecular testing and (18)fluorodeoxyglucose-positron emission tomography/computed tomography as diagnostic tools...
February 3, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29393104/downregulated-expression-of-trpv2-in-peripheral-blood-cells-following-acute-myocardial-infarction-is-inversely-correlated-with-serum-levels-of-crp-and-troponin-i
#9
Zach Rozenbaum, Lena Cohen, Einat Bigelman, Yacov Shacham, Gad Keren, Michal Entin-Meer
OBJECTIVES: We have recently shown that the transient receptor potential vanilloid 2 (TRPV2) channel is exclusively upregulated in rat/murine peri-infarct monocytes/macrophages following an acute myocardial infarction (AMI), and that this overexpression might be detrimental for cardiac recovery. We aimed to characterize the expression levels of TRPV2 in peripheral blood mononuclear cells (PBMCs) of AMI patients relative to individuals with normal coronaries, and to analyze potential associations with inflammatory and cardiac ischemic markers...
January 26, 2018: Cardiology
https://www.readbyqxmd.com/read/29382606/outcome-of-infective-endocarditis-in-the-current-era-early-predictors-of-poor-prognosis
#10
Maria Carmo Pereira Nunes, Milton Henriques Guimarães-Júnior, Pedro Henrique Oliveira Murta Pinto, Rodrigo Matos Pinto Coelho, Thais Lins Souza Barros, Nicole de Paula Aarão Faleiro Maia, Dayane Amaral Madureira, Rodrigo Citton Padilha Reis, Paulo Henrique Nogueira Costa, Renato Bráulio, Cláudio Léo Gelape, Teresa Cristina Abreu Ferrari
BACKGROUND: Early identification of patients at risk of IE complications using parameters obtained routinely is essential for clinical decision making guidance. This study aimed to identify a parameter at hospital admission that predicts outcome, adding value to other well-known factors of poor prognosis in IE. METHODS: Two hundred and three patients with IE were included. Clinical evaluation, echocardiography, blood cultures, and routine laboratory tests were performed at hospital admission...
January 27, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29375221/the-association-between-monocyte-hdl-c-ratio-and-syntax-score-and-syntax-score-ii-in-stemi-patients-treated-with-primary-pci
#11
Metin Çağdaş, Süleyman Karakoyun, Mahmut Yesin, İbrahim Rencüzoğulları, Yavuz Karabağ, Mahmut Uluganyan, Mustafa Ozan Gürsoy, İnanç Artaç, Doğan İliş, Eray Atalay, Öznur Sadioğlu Çağdaş
Background: Monocyte to high-density-lipoprotein cholesterol ratio (MHR) simply reflects proatherogenic and antiatherogenic balance and high level of this ratio is associated with severity of coronary atherosclerosis and cardiac events. We investigated the association between MHR and coronary artery disease severity using SYNTAX score and SYNTAX score II (SSII) in ST-elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (pPCI). Methods: A total of 315 consecutive patients with STEMI who underwent pPCI from January 2014 to January 2016 were enrolled...
January 2018: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29366580/urinary-biomarkers-may-provide-prognostic-information-for-subclinical-acute-kidney-injury-after-cardiac-surgery
#12
Christian Albert, Annemarie Albert, Johanna Kube, Rinaldo Bellomo, Nicholas Wettersten, Hermann Kuppe, Sabine Westphal, Michael Haase, Anja Haase-Fielitz
OBJECTIVE: This study aimed to determine the biomarker-specific outcome patterns and short-and long-term prognosis of cardiac surgery-asoociated acute kidney injury (AKI) identified by standard criteria and/or urinary kidney biomarkers. METHODS: Patients enrolled (N = 200), originated a German multicenter study (NCT00672334). Standard risk injury, failure, loss, and end-stage renal disease classification (RIFLE) criteria (including serum creatinine and urine output) and urinary kidney biomarker test result (neutrophil gelatinase-associated lipocalin, midkine, interleukin 6, and proteinuria) were used for diagnosis of postoperative AKI...
December 22, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29354906/baseline-and-postoperative-levels-of-c-reactive-protein-and-interleukins-as-inflammatory-predictors-of-atrial-fibrillation-following-cardiac-surgery-a-systematic-review-and-meta-analysis
#13
Alexander Weymann, Aron-Frederik Popov, Anton Sabashnikov, Sadeq Ali-Hasan-Al-Saegh, Mikhail Ryazanov, Gary Tse, Seyed Jalil Mirhosseini, Tong Liu, Mohammadreza Lotfaliani, Meghdad Sedaghat, William L Baker, Azam Ghanei, Senol Yavuz, Mohamed Zeriouh, Payman Izadpanah, Hamidreza Dehghan, Luca Testa, Maryam Nikfard, Michel Pompeu Barros de Oliveira Sá, Ahmed Mashhour, Luis Nombela-Franco, Mohammad Rezaeisadrabadi, Fabrizio D'Ascenzo, Konstantin Zhigalov, Umberto Benedetto, Soroosh Aminolsharieh Najafi, Marcin Szczechowicz, Leonardo Roever, Lei Meng, Mengqi Gong, Abhishek J Deshmukh, Tullio Palmerini, Cecilia Linde, Krzysztof J Filipiak, Gregg W Stone, Giuseppe Biondi-Zoccai, Hugh Calkins
BACKGROUND AND AIM: Postoperative atrial fibrillation (POAF) is a leading arrhythmia with high incidence and serious clinical implications after cardiac surgery. Cardiac surgery is associated with systemic inflammatory response including increase in cytokines and activation of endothelial and leukocyte responses. This systematic review and meta-analysis aimed to determine the strength of evidence for evaluating the association of inflammatory markers, such as C-reactive protein (CRP) and interleukins (IL) with POAF following isolated coronary artery bypass grafting (CABG), isolated valvular surgery or combination of these procedures...
January 22, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29344381/impact-of-nutritional-indices-on-mortality-in-patients-with-heart-failure
#14
Akiomi Yoshihisa, Yuki Kanno, Shunsuke Watanabe, Tetsuro Yokokawa, Satoshi Abe, Makiko Miyata, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Takafumi Ishida, Yasuchika Takeishi
Background: Malnutrition is a common condition that is associated with adverse prognosis in patients with heart failure (HF). The Prognostic Nutritional Index (PNI), Geriatric Nutritional Risk Index (GNRI) and controlling nutritional status (CONUT) have all been used as objective indices for evaluating nutritional status. We aimed to clarify the relationship between these nutritional indices and the parameters of inflammatory markers, cardiac function and exercise capacity, as well as to compare the ability of these indexes for predicting mortality...
2018: Open Heart
https://www.readbyqxmd.com/read/29344021/relevance-of-endothelial-cell-specific-molecule-1-endocan-plasma-levels-for-predicting-pulmonary-infection-after-cardiac-surgery-in-chronic-kidney-disease-patients-the-endolung-pilot-study
#15
Andréa Perrotti, Camille Chenevier-Gobeaux, Fiona Ecarnot, Benoit Barrucand, Philippe Lassalle, Enrica Dorigo, Sidney Chocron
Objectives: This pilot study aimed to evaluate the relevance of endocan plasma levels for predicting pulmonary infection after cardiac surgery in patients with chronic kidney disease (CKD). Methods: Serum collected in a previous prospective cohort study (from 166 patients with preoperative CKD who underwent cardiac surgery) was used. Five patients with postoperative pulmonary infection were compared with 15 randomly selected CKD patients with an uneventful outcome...
December 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29331339/cardiopulmonary-hemodynamics-and-c-reactive-protein-as-prognostic-indicators-in-compensated-and-decompensated-cirrhosis
#16
Laura Turco, Guadalupe Garcia-Tsao, Ilenia Magnani, Marcello Bianchini, Martina Costetti, Cristian Caporali, Stefano Colopi, Emilio Simonini, Nicola De Maria, Federico Banchelli, Rosario Rossi, Erica Villa, Filippo Schepis
BACKGROUND AND AIMS: The main stages of cirrhosis (compensated and decompensated) have been substaged based on clinical, endoscopic, and portal pressure (determined by the hepatic venous pressure gradient, HVPG) features. Vasodilatation leading to a hyperdynamic circulatory state is central in the development of a late decompensated stage with inflammation being currently considered a key driver. We aimed to assess hepatic/systemic hemodynamics and inflammation (by C reactive protein, CRP) among the different substages of cirrhosis and to investigate their interrelationship and prognostic relevance...
January 10, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29325227/soluble-st2-in-end-stage-heart-failure-before-and-after-support-with-a-left-ventricular-assist-device
#17
C C S Tseng, M M H Huibers, L H Gaykema, E Siera-de Koning, F Z Ramjankhan, A S Maisel, N de Jonge
BACKGROUND: The interleukin-33 (IL-33)/supressor of tumorigenicity 2 (ST2) pathway is suggested to play an important role in fibrosis, remodeling and the progression of heart failure (HF). Increased soluble (sST2) levels are associated with adverse outcome in the average HF population. Less is known about sST2 levels in end-stage HF. Therefore, we studied sST2 levels in end-stage HF and the effect of unloading by left ventricular assist device (LVAD) support on sST2 levels. METHOD AND RESULTS: Serial plasma measurements of sST2 were performed pre-implantation and 1, 3 and 6 months after (LVAD) implantation in 38 patients...
January 11, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29321509/novel-haemodialysis-hd-treatment-employing-molecular-hydrogen-h2-enriched-dialysis-solution-improves-prognosis-of-chronic-dialysis-patients-a-prospective-observational-study
#18
Masaaki Nakayama, Noritomo Itami, Hodaka Suzuki, Hiromi Hamada, Ryo Yamamoto, Kazumasa Tsunoda, Naoyuki Osaka, Hirofumi Nakano, Yukio Maruyama, Shigeru Kabayama, Ryoichi Nakazawa, Mariko Miyazaki, Sadayoshi Ito
Recent studies have revealed unique biological characteristics of molecular hydrogen (H2) as an anti-inflammatory agent. We developed a novel haemodialysis (E-HD) system delivering an H2 (30-80 ppb)-enriched dialysis solution by water electrolysis, and conducted a non-randomized, non-blinded, prospective observational study exploring its clinical impact. Prevalent chronic HD patients were allocated to either the E-HD (n = 161) group or the conventional HD (C-HD: n = 148) group, and received the respective HD treatments during the study...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29262409/early-markers-of-cardiovascular-risk-in-autosomal-dominant-polycystic-kidney-disease
#19
Silvia Lai, Daniela Mastroluca, Silvia Matino, Valeria Panebianco, Antonio Vitarelli, Lidia Capotosto, Irene Turinese, Paolo Marinelli, Marco Rossetti, Alessandro Galani, Pia Baiocchi, Anna R D'Angelo, Paolo Palange
BACKGROUND/AIMS: Cardiovascular disease is the most frequent cause of morbidity and mortality in autosomal dominant polycystic kidney disease (ADPKD) patients, often before the onset of renal failure, and the pathogenetic mechanism is not yet well elucidated. The aim of the study was to identify early and noninvasive markers of cardiovascular risk in young ADPKD patients, in the early stages of disease. METHODS: A total of 26 patients with ADPKD and 24 control group, matched for age and sex, were enrolled, and we have assessed inflammatory indexes, mineral metabolism, metabolic state and markers of atherosclerosis and endothelial dysfunction (carotid intima media thickness (IMT), ankle brachial index (ABI), flow mediated dilation (FMD), renal resistive index (RRI), left ventricular mass index (LVMI)) and cardiopulmonary exercise testing (CPET), maximal O2 uptake (V'O2max), and O2 uptake at lactic acid threshold (V'O2@LT)...
December 15, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29250299/oxidative-stress-related-parthanatos-of-circulating-mononuclear-leukocytes-in-heart-failure
#20
Tamás Bárány, Andrea Simon, Gergő Szabó, Rita Benkő, Zsuzsanna Mezei, Levente Molnár, Dávid Becker, Béla Merkely, Endre Zima, Eszter M Horváth
Background: The present study aims to examine the oxidative stress-related activation of poly(ADP-ribose) polymerase (PARP), a cause of parthanatos in circulating mononuclear leukocytes of patients with chronic heart failure (CHF), that was rarely investigated in the human setting yet. Methods: Patients with CHF (n = 20) and age- and body mass index-matched volunteers (n = 15) with a normal heart function were enrolled. C-reactive protein, N-terminal probrain-type natriuretic peptide (pro-BNP), plasma total peroxide level (PRX), plasma total antioxidant capacity (TAC), oxidative stress index (OSI), leukocyte lipid peroxidation (4-hydroxynonenal; HNE), protein tyrosine nitration (NT), poly(ADP-ribosyl)ation (PARylation), and apoptosis-inducing factor (AIF) translocation were measured in blood samples of fasting subjects...
2017: Oxidative Medicine and Cellular Longevity
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