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https://www.readbyqxmd.com/read/28985195/effects-of-dexamethasone-on-early-cognitive-decline-after-cardiac-surgery-a-randomised-controlled-trial
#1
Sandro Glumac, Goran Kardum, Lidija Sodic, Daniela Supe-Domic, Nenad Karanovic
BACKGROUND: Postoperative cognitive decline (POCD), a very common complication after cardiac surgery, is characterised by impairment of both memory function and intellectual ability as well as being associated with increased use of healthcare resources. The investigators focused on the role of the inflammatory response to a surgical procedure as a potential factor involved in the pathogenesis of POCD. OBJECTIVE: The use of prophylactic dexamethasone to attenuate the inflammatory response was hypothesised to reduce the risk of POCD...
November 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28983818/in-search-of-an-efficient-strategy-to-monitor-disease-status-of-chronic-heart-failure-outpatients-added-value-of-blood-biomarkers-to-clinical-assessment
#2
N van Boven, K M Akkerhuis, S S Anroedh, L C Battes, K Caliskan, W Yassi, O C Manintveld, J H Cornel, A A Constantinescu, H Boersma, V A Umans, I Kardys
INTRODUCTION: Blood biomarkers have the potential to monitor the severity of chronic heart failure (CHF). Studies correlating repeated measurements of blood biomarkers with repeatedly assessed New York Heart Association (NYHA) class over a prolonged follow-up period, and concomitantly investigating their associations with clinical endpoints, have not yet been performed. METHODS: Between 2011-2013, 263 CHF patients were included. At inclusion and subsequently every 3 months, we measured N‑terminal pro-B-type natriuretic (NT-proBNP), high-sensitivity troponin T (Hs-TnT) and C‑reactive protein (CRP), and assessed NYHA class...
October 5, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28980281/evaluating-the-effects-of-cardiac-resynchronization-therapy-on-pathophysiological-pathways-of-heart-failure-using-surrogate-biomarkers
#3
Hamza Sunman, Adem Özkan, Hikmet Yorgun, Uğur Canpolat, Erdem Karabulut, Tülin Bayrak, Ergün Barış Kaya, Lale Tokgözoğlu, Necla Özer, Asuman Özkara, Kudret Aytemir, Ali Oto
BACKGROUND: Several studies have investigated the effects of cardiac resynchronization therapy (CRT) on heart failure (HF), but none have evaluated the pathophysiological pathways involved in a single group of patients. Therefore, this study aims to assess the long-term effects of CRT on six different pathophysiological pathways involved in the process of HF by the use of surrogate biomarkers. METHODS: In a group 44 patients with HF, six groups of biomarkers were measured, both at baseline and 1 year after CRT implantation: Inflammation (interleukin [IL]-4, IL-6, tumor necrosis factor [TNF]-α, high sensitive C-reactive protein [hsCRP]); oxidative stress (myeloperoxidase, oxidized low-density lipoprotein [oxLDL], uric acid); extracellular matrix (ECM) remodeling (matrix metalloproteinase [MMP]-2 and -9, galectin-3, procollagen III N-terminal propeptide [prokol-3NT]); neurohormonal pathways (endothelin-1, chromogranin-A); myocyte injury (troponin T, creatine kinase MB fraction [CK-MB]), myocyte stress (B-type natriuretic peptide [BNP])...
October 5, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28977057/importance-of-clinical-and-laboratory-findings-in-the-diagnosis-and-surgical-prognosis-of-patients-with-constrictive-pericarditis
#4
Fábio Fernandes, Dirceu Thiago Pessoa de Melo, Felix José Alvarez Ramires, Ricardo Ribeiro Dias, Marcio Tonini, Vinicius Dos Santos Fernandes, Carlos Eduardo Rochitte, Carlos Henrique Valente Moreira, Charles Mady
BACKGROUND: International studies have reported the value of the clinical profile and laboratory findings in the diagnosis of constrictive pericarditis. However, Brazilian population data are scarce. OBJECTIVE: To assess the clinical characteristics, sensitivity of imaging tests and factors related to the death of patients with constrictive pericarditis undergoing pericardiectomy. METHODS: Patients with constrictive pericarditis surgically confirmed were retrospectively assessed regarding their clinical and laboratory variables...
October 2, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28972487/effect-the-cardiometabolic-risk-factors-on-vascular-aging-in-patients-with-non-alcoholic-fatty-liver-disease-concomitant-with-subclinical-hypothyroidism
#5
E Kolesnikova, A Potapenko
The article presents the analysis of the relationship between thyroid function abnormality -subclinical hypothyroidism (SH) and non-alcoholic fatty liver disease (NAFLD), depending on age peculiarities (>50 years and <50 years), and the risk of cardiovascular complications in this category of patients. Research of early predictors of cardiovascular complications: dyslipidemia, insulin resistance, inflammatory marker- C-reactive protein, marker of vascular aging-telomerase activity and marker of endothelial dysfunction (ED) - CDECs and VEGF-A that have been analyzed are on the front burner...
September 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28960777/prognostic-importance-of-emerging-cardiac-inflammatory-and-renal-biomarkers-in-chronic-heart-failure-patients-with-reduced-ejection-fraction-and-anaemia-red-hf-study
#6
Paul Welsh, Lei Kou, Changhong Yu, Inder Anand, Dirk J van Veldhuisen, Aldo P Maggioni, Akshay S Desai, Scott D Solomon, Marc A Pfeffer, Sunfa Cheng, Lars Gullestad, Pål Aukrust, Thor Ueland, Karl Swedberg, James B Young, Michael W Kattan, Naveed Sattar, John J V McMurray
AIMS: To test the prognostic value of emerging biomarkers in the Reduction of Events by Darbepoetin Alfa in Heart Failure (RED-HF) trial. METHODS AND RESULTS: Circulating cardiac [N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high-sensitivity troponin T (hsTnT)], neurohumoral [mid-regional pro-adrenomedullin (MR-proADM) and copeptin], renal (cystatin C), and inflammatory [high-sensitivity C-reactive protein (hsCRP)] biomarkers were measured at randomization in 1853 participants with complete data...
September 27, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28950341/increased-arterial-stiffness-in-childhood-onset-diabetes-a-cardiovascular-magnetic-resonance-study
#7
Martin Heier, Knut Haakon Stensæth, Cathrine Brunborg, Ingebjørg Seljeflot, Hanna Dis Margeirsdottir, Kristian F Hanssen, Knut Dahl-Jørgensen
Aims: Arterial stiffness is a strong predictor of cardiovascular events. We aimed to assess the impact of type 1 diabetes (T1D) on arterial stiffness and cardiac function in young adults. Methods and results: Aortic pulse wave velocity (PWV), distensibility, left ventricular (LV) function and LV mass were measured by cardiovascular magnetic resonance imaging (CMR) in 47 T1D patients and 33 healthy controls. All were participants in the Atherosclerosis and Childhood Diabetes study, with baseline values registered 5 years previously...
July 25, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28937313/shed-blood-separation-and-cell-saver-an-integral-part-of-miecc-shed-blood-separation-and-its-influence-on-the-perioperative-inflammatory-response-during-coronary-revascularization-with-minimal-invasive-extracorporeal-circulation-systems-a-randomized-controlled
#8
Adrian Bauer, Harald Hausmann, Jan Schaarschmidt, Martin Scharpenberg, Dirk Troitzsch, Peter Johansen, Hans Nygaard, Thomas Eberle, J Michael Hasenkam
OBJECTIVE: The postoperative systemic inflammatory response after cardiopulmonary bypass (CPB) is still an undesirable side-effect after cardiac surgery. It is most likely caused by blood contact with foreign surfaces and by the surgical trauma itself. However, the recirculation of activated shed mediastinal blood is another main cause of blood cell activation and cytokine release. Minimal invasive extracorporeal circulation (MiECC) comprises a completely closed circuit, coated surfaces and the separation of suction blood...
September 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28927867/cardiovascular-autonomic-regulation-inflammation-and-pain-in-rheumatoid-arthritis
#9
Ahmed M Adlan, Jet J C S Veldhuijzen van Zanten, Gregory Y H Lip, Julian F R Paton, George D Kitas, James P Fisher
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory condition characterised by reduced heart rate variability (HRV) of unknown cause. We tested the hypothesis that low HRV, indicative of cardiac autonomic cardiovascular dysfunction, was associated with systemic inflammation and pain. Given the high prevalence of hypertension (HTN) in RA, a condition itself associated with low HRV, we also assessed whether the presence of hypertension further reduced HRV in RA. METHODS: In RA-normotensive (n=13), RA-HTN (n=17), normotensive controls (NC; n=17) and HTN (n=16) controls, blood pressure and heart rate were recorded...
September 13, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28927169/c-reactive-protein-level-on-admission-and-time-to-and-cause-of-death-in-patients-hospitalized-for-acute-heart-failure
#10
Yuichiro Minami, Katsuya Kajimoto, Naoki Sato, Nobuhisa Hagiwara, Teruo Takano
Aims: We analysed the association between C-reactive protein (CRP) levels measured on admission and timing and cause of death among patients hospitalized for acute heart failure (AHF). Methods and Results: The ATTEND study prospectively registered 4777 hospitalized AHF patients with data on CRP levels on admission. Mortality risks were assessed by univariable and multivariable Cox proportional and non-proportional hazards models. The overall median CRP level was 5...
April 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28923627/associations-among-cardio-ankle-vascular-index-carotid-intima-media-thickness-and-fibroblast-growth-factor-21-levels-in-kidney-transplant-patients
#11
T Trakarnvanich, S Prommool, S Kurathong, T Teepprasan, Y Wang
BACKGROUND: Cardiovascular disease is the major cause of death in patients with chronic kidney disease, even after renal transplantation. Cardio-ankle vascular index (CAVI) provides an indicator of arterial stiffness, whereas fibroblast growth factor-21 (FGF-21) levels may provide a biomarker for atherosclerotic disease. We investigated the association between CAVI and FGF-21 and their relationships to carotid intima-media thickness (IMT) and other cardiovascular risk factors. METHODS: This study included 90 renal transplant patients...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28916335/troxerutin-abrogates-mitochondrial-oxidative-stress-and-myocardial-apoptosis-in-mice-fed-calorie-rich-diet
#12
Rajagopalan Geetha, Chandrasekaran Sathiya Priya, Carani Venkatraman Anuradha
Mitochondrial oxidative stress plays a major role in the pathogenesis of myocardial apoptosis in metabolic syndrome (MS) patients. In this study, we investigated the effect of troxerutin (TX), an antioxidant on mitochondrial oxidative stress and apoptotic markers in heart of mice fed fat and fructose-rich diet. Adult male Mus musculus mice were fed either control diet or high fat, high fructose diet (HFFD) for 60 days to induce MS. Mice from each dietary group were divided into two on the 16th day and were either treated or untreated with TX (150 mg/kg bw, p...
September 12, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28899471/-a-report-of-two-children-with-fever-headache-and-purpura
#13
Hong-Bo Xu, Mei Tan, Jian Lu, Mao-Qiang Tian, Yan Chen
In this study, two school-aged children had an acute onset in spring and had the manifestations of fever, headache, vomiting, disturbance of consciousness, purpura and ecchymosis, and positive meningeal irritation sign. There were increases in peripheral white blood cells and neutrophils, but reductions in the hemoglobin level and platelet count in the two children. They had a significant increase in C-reactive protein. There were hundreds or thousands of white blood cells in the cerebrospinal fluid, mainly neutrophils...
September 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28879464/prevalence-of-subclinical-enteric-alpha-1-antitrypsin-loss-in-children-with-univentricular-circulation-following-total-cavopulmonary-connection
#14
Colm R Breatnach, Aoife Cleary, Terence Prendiville, Kathleen Crumlish, Helene Murchan, Colin J McMahon
Protein-Losing Enteropathy post Fontan palliation is associated with significant morbidity and mortality. To date, very little research has been carried out to improve early identification of enteric protein loss in these patients. We hypothesise that subclinical enteric protein loss may occur in patients post Fontan surgery. A cross-sectional study was performed on 43 patients post Fontan surgery. We collected specimens of stool and blood from patients with no symptoms of protein-losing enteropathy post Fontan...
September 6, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28860666/features-of-cardiac-remodeling-in-patients-with-acute-coronary-syndrome-complicated-with-rheumatoid-arthritis
#15
Lili Pan, Tian Wang
Cardiovascular diseases are important factors to increased morbidity and mortality in patients with rheumatoid arthritis (RA). The aim of this study is to investigate the effects of RA on cardiac remodeling in patients with acute coronary syndrome (ACS). Sixty-one patients with ACS complicated with RA (RA group) and 55 age- and sex-matched patients with ACS without RA (control group) were enrolled. We compared the parameters of laboratory and echocardiogram across the 2 groups. Levels of serum brain natriuretic peptide in patients with RA were significantly higher than control group...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28851286/influence-of-the-postoperative-inflammatory-response-on-cognitive-decline-in-elderly-patients-undergoing-on-pump-cardiac-surgery-a-controlled-prospective-observational-study
#16
Endre Nemeth, Katalin Vig, Kristof Racz, Kinga B Koritsanszky, Klara I Ronkay, Fumiko P Hamvas, Csaba Borbély, Ajandek Eory, Bela Merkely, Janos Gal
BACKGROUND: The role of non-infective inflammatory response (IR) in the aetiology of postoperative cognitive dysfunction (POCD) is still controversial. The aim of this controlled, prospective observational study was to assess the possible relationship between the grade of IR, defined by procalcitonin (PCT) changes, and development of POCD related to cardiac surgery. METHODS: Forty-two patients, who were ≥ 60 years of age and scheduled for elective cardiac surgery, were separated into the low inflammatory (LIR) and high inflammatory (HIR) response groups based on their PCT levels measured on the first postoperative day...
August 29, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28846677/small-airway-dysfunction-in-smokers-with-stable-ischemic-heart-disease
#17
Claudia Llontop, Cristina Garcia-Quero, Almudena Castro, Regina Dalmau, Raquel Casitas, Raúl Galera, Alberto Iglesias, Elisabet Martinez-Ceron, Joan B Soriano, Francisco García-Río
BACKGROUND: A higher prevalence of airflow limitation (AL) has been described in patients with ischemic heart disease (IHD). Although small airway dysfunction (SAD) is an early feature of AL, there is little information about its occurrence in IHD patients. Our objective was to describe the prevalence of SAD in IHD patients, while comparing patient-related outcomes and future health risk among IHD patients with AL, SAD and normal lung function. METHODS: In 118 consecutive smoking patients with stable IHD, comorbidities, utilization of healthcare resources, current treatment, blood biochemistry and health status were recorded...
2017: PloS One
https://www.readbyqxmd.com/read/28843718/prospective-randomized-study-evaluating-the-effects-of-perclot%C3%A2-polysaccharide-hemostatic-system-application-in-patients-with-high-bleeding-risk-undergoing-cardiac-rhythm-device-implantation
#18
Verena Tscholl, Felicitas Spann, Jane Moses, Patrick Nagel, Barbara Bellmann, Sebastian Biewener, Marie Amtenbrink, Andrea Stroux, Andreas Rillig, Ulf Landmesser, Mattias Roser
BACKGROUND: Thus far, the topic hemostatic agent PerClot® is used for surgical procedures. Data about the use of PerClot® for cardiac-rhythm-devices (CRD) implantation are missing. The aim of this study was to evaluate the safety and efficacy of PerClot® in patients with high bleeding risk. METHODS AND RESULTS: In this prospective randomized study we planned to include 150 patients admitted for CRD-Implantation receiving anticoagulation and/or dual-antiplatelet-therapy...
December 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28832572/mediterranean-diet-and-prognosis-of-first-diagnosed-acute-coronary-syndrome-patients-according-to-heart-failure-phenotype-hellenic-heart-failure-study
#19
M Kouvari, C Chrysohoou, P Aggelopoulos, E Tsiamis, K Tsioufis, C Pitsavos, D Tousoulis
BACKGROUND/OBJECTIVES: Nutrition in secondary prevention of Acute Coronary Syndrome (ACS) is inadequately investigated. We sought to evaluate the role of Mediterranean diet in prognosis of first-diagnosed ACS patients, according to heart failure type. SUBJECTS/METHODS: in 2006-2009, 1000 consecutive patients hospitalized at First Cardiology Clinic of Athens with ACS diagnosis were enrolled in the study. In 2016, 10-year follow-up was performed (75% participation rate)...
August 23, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28828748/relationship-between-matrix-metalloproteinase-3-serum-level-and-pulmonary-artery-systolic-pressure-in-patients-with-rheumatoid-arthritis
#20
Tetsuro Sugiura, Mikio Kamioka, Shigeo Yamanaka, Taisuke Hisahara, Yoko Hirakawa, Yoshihisa Matsumura
Activity of rheumatoid arthritis (RA) has been evaluated by various biomarkers including matrix metalloproteinase (MMP)-3, but the relationship between the levels of biomarkers and elevation of pulmonary artery systolic pressure (PAs) has not been evaluated in detail. We sought to determine the utility of MMP-3 with other biomarkers for the prediction of PAs in patients with RA. Blood samples for biomarkers and echocardiography were obtained in 100 consecutive patients with RA. PAs was measured by continuous-wave Doppler echocardiography and was correlated with laboratory findings...
August 21, 2017: Heart and Vessels
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