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pancreatic exocrine insufficiency

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https://www.readbyqxmd.com/read/27917087/predicting-pancreatic-exocrine-insufficiency-with-eus-elastography
#1
J Enrique Domínguez-Muñoz
No abstract text is available yet for this article.
August 2016: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27896656/pancreatitis-after-pancreatoduodenectomy-predicts-clinically-relevant-postoperative-pancreatic-fistula
#2
C M Kühlbrey, N Samiei, O Sick, F Makowiec, U T Hopt, U A Wittel
BACKGROUND: Morbidity after pancreas resection is still high with postoperative pancreatic fistulas (POPF) being the most frequent complication. However, exocrine insufficiency seems to protect from POPF. In clinical practice, patients showing increased postoperative systemic amylase concentrations appear to frequently develop POPF. We therefore retrospectively examined the occurrence of systemic amylase increase after pancreas resections and its association with the clinical course. PATIENTS AND METHODS: Perioperative data from 739 consecutive pancreas resections were assessed in a prospectively maintained SPSS database...
November 28, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27888869/latest-advances-in-chronic-pancreatitis
#3
J Enrique Domínguez-Muñoz
This article summarizes some of the recent and clinically relevant advances in chronic pancreatitis. These advances mainly concern the definition of the disease, the etiological diagnosis of idiopathic disease, the correlation between fibrosis degree and pancreatic secretion in the early stages of chronic pancreatitis, the treatment of the disease and of pain, the clinical relevance of pancreatic exocrine insufficiency, and the diagnosis of autoimmune pancreatitis. A new mechanistic definition of chronic pancreatitis has been proposed...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27878466/pancreatic-exocrine-insufficiency-comparing%C3%A2-fecal-elastase-1-with-72-h-stool-for-fecal-fat-estimation
#4
Sudipta Dhar Chowdhury, Reuben Thomas Kurien, Anup Ramachandran, Anjilivelil Joseph Joseph, Ebby George Simon, Amit Kumar Dutta, Deepu David, Bharath Kumar C, Prassana Samuel, K A Balasubramaniam
INTRODUCTION: Identification of pancreatic exocrine insufficiency (PEI) is important in the management of chronic pancreatitis. The 72-h stool for fecal fat estimation (FFE) has long been considered a gold standard indirect test for the diagnosis of PEI. However, the test is cumbersome for both patients and laboratory personnel alike. In this study, we aimed to assess fecal elastase 1 (FE1) as an alternate to FFE for the diagnosis of PEI. METHODS: In all, 87 consecutive patients diagnosed with chronic pancreatitis were included in this study...
November 23, 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27864215/atrophic-exocrine-pancreatic-insufficiency-associated-with-anti-pd1-therapy
#5
G Long, A Hoadley, N Sandanayake
No abstract text is available yet for this article.
November 17, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27861351/small-amounts-of-tissue-preserve-pancreatic-function-long-term-follow-up-study-of-middle-segment-preserving-pancreatectomy
#6
Zipeng Lu, Jie Yin, Jishu Wei, Cuncai Dai, Junli Wu, Wentao Gao, Qing Xu, Hao Dai, Qiang Li, Feng Guo, Jianmin Chen, Chunhua Xi, Pengfei Wu, Kai Zhang, Kuirong Jiang, Yi Miao
Middle-segment preserving pancreatectomy (MPP) is a novel procedure for treating multifocal lesions of the pancreas while preserving pancreatic function. However, long-term pancreatic function after this procedure remains unclear.The aims of this current study are to investigate short- and long-term outcomes, especially long-term pancreatic endocrine function, after MPP.From September 2011 to December 2015, 7 patients underwent MPP in our institution, and 5 cases with long-term outcomes were further analyzed in a retrospective manner...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27851333/1698-refeeding-syndrome-in-pancreatic-exocrine-insufficiency-replacement-therapy
#7
Riley Jones, Long Vu, Haroon Ahmed, Edwin Hargitt, Kalpan Desai, Vishal Jivan
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27846137/utility-of-direct-pancreatic-function-testing-in-children
#8
Ligia Alfaro Cruz, Andrea Parniczky, Allison Mayhew, Lindsey N Hornung, Tom K Lin, Joseph J Palermo, Kimberly Jackson, Maisam Abu-El-Haija
OBJECTIVES: Exocrine pancreatic insufficiency (EPI) can have a significant impact on a child's growth and nutrition. Our aim was to evaluate the utility of direct endoscopic pancreatic function testing (ePFT) in pediatrics. METHODS: A single-center retrospective chart review was performed of children who underwent ePFT from December 2007 through February 2015. Endoscopic pancreatic function testings were performed by 1 of 2 methods: (1) intravenous cholecystokinin, followed by the collection of a single duodenal aspirate at 10 minutes, or (2) intravenous cholecystokinin or secretin, followed by the collection of 3 duodenal aspirates at a 5, 10, and 15 minutes...
November 11, 2016: Pancreas
https://www.readbyqxmd.com/read/27846134/pancreatic-insufficiency-secondary-to-tobacco-exposure-a-controlled-cross-sectional-evaluation
#9
Kara L Raphael, Saurabh Chawla, Sungjin Kim, Christopher G Keith, David R Propp, Zhengjia N Chen, Kevin E Woods, Steven A Keilin, Qiang Cai, Field F Willingham
OBJECTIVES: Tobacco exposure is an established risk factor for pancreatic cancer and chronic pancreatitis; however, its role in pancreatic insufficiency is not clear. METHODS: This controlled, cross-sectional study examined smokers and nonsmokers with no history of pancreatic disease. Histories and validated inventories of alcohol and tobacco use were obtained, and pancreatic insufficiency was assessed using the fecal elastase-1 assay. RESULTS: Of 7854 patients approached, 226 were interviewed and 200 enrolled...
November 11, 2016: Pancreas
https://www.readbyqxmd.com/read/27832324/secretin-stimulated-mri-assessment-of-exocrine-pancreatic-function-in-patients-with-cystic-fibrosis-and-healthy-controls
#10
Adnan Madzak, Trond Engjom, Gaute K Wathle, Søren Schou Olesen, Erling Tjora, Pål R Njølstad, Birger Norderud Lærum, Asbjørn Mohr Drewes, Georg Dimcevski, Jens Brøndum Frøkjær, Ingfrid S Haldorsen
PURPOSE: Secretin-stimulated magnetic resonance imaging (s-MRI) and pancreatic diffusion weighted imaging (DWI) are novel non-invasive imaging techniques for assessment of exocrine pancreatic insufficiency (EPI). The aim was to validate s-MRI assessed pancreatic secreted volume using novel semi-automatic quantification software, and to assess the ability of s-MRI with DWI to diagnose EPI in patients with cystic fibrosis (CF). METHODS: s-MRI and DWI was performed in 19 patients with CF (median age 21 years; range 16-56; eight men) and in 10 healthy controls (HC) (median age 46 years; range 20-65; four men)...
November 10, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27824641/permanent-indwelling-transmural-stents-for-endoscopic-treatment-of-patients-with-disconnected-pancreatic-duct-syndrome-long-term-results
#11
Felix I Téllez-Ávila, Luis E Casasola-Sánchez, Miguel Á Ramírez-Luna, Ángela Saúl, Enrique Murcio-Pérez, Carlos Chan, Luis Uscanga, Gilberto Duarte-Medrano, Francisco Valdovinos-Andraca
INTRODUCTION: Disconnected pancreatic duct syndrome (DPDS) is defined as the complete disruption of the main pancreatic duct, the result are peripancreatic fluid collections or pancreatic leaks. The aim of this study was to report the results of derivative endoscopic treatment of DPDS in a long-term follow-up period. PATIENTS AND METHODS: We performed a retrospective analysis of prospectively collected data. Endoscopic treatment consisted of transmural drainage with 2 double pigtail plastic stents (7 F and 4 cm) deployed under endoscopic ultrasound guidance...
November 7, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27816407/embedding-fistulojejunostomy-an-easy-and-secure-technique-for-refractory-external-pancreatic-fistula
#12
Shao-Ciao Luo, Shao-Bin Cheng, Cheng-Chung Wu, Chu-Chun Huang, Yi-Ling Lin, Fang-Ku P'eng
BACKGROUND: Refractory external pancreatic fistula (REPF) is a rare but troublesome event. Fistulojejunostomy with direct suture of the fistula wall to jejunal wall has been demonstrated as a solution. However, it is sometimes technically difficult and some cases of failure were reported. METHODS: An embedding fistulojejunostomy (EFJ) was designed. The fistula tract was detached from the abdominal wall and impactedly inserted into a Roux-en-Y jejunal lumen without direct suture of the fistula wall to the jejunal wall...
November 2, 2016: Asian Journal of Surgery
https://www.readbyqxmd.com/read/27811505/early-and-late-complications-after-surgery-for-men1-related-nonfunctioning-pancreatic-neuroendocrine-tumors
#13
Sjoerd Nell, Inne H M Borel Rinkes, Helena M Verkooijen, Bert A Bonsing, Casper H van Eijck, Harry van Goor, Ruben H J de Kleine, Geert Kazemier, Elisabeth J Nieveen van Dijkum, Cornelis H C Dejong, Gerlof D Valk, Menno R Vriens
OBJECTIVE: To estimate short and long-term morbidity after pancreatic surgery for multiple endocrine neoplasia type 1 (MEN1)-related nonfunctioning pancreatic neuroendocrine tumors (NF-pNETs). BACKGROUND: Fifty percent of the MEN1 patients harbor multiple NF-pNETs. The decision to proceed to NF-pNET surgery is a balance between the risk of disease progression versus the risk of surgery-related morbidity. Currently, there are insufficient data on the surgical complications after MEN1 NF-pNET surgery...
November 1, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27804929/-long-term-results-of-severe-acute-pancreatitis-management
#14
A S Ermolov, D A Blagovestnov, M L Rogal', D A Omel'yanovich
AIM: To assess the long-term results and quality of life of patients after different medical and tactical approaches in treatment of severe acute pancreatitis. MATERIAL AND METHODS: Long-term outcomes were studied in 210 patients with severe acute pancreatitis for the period 2003-2013. There were 144 (68.6%) men. RESULTS: The quality of life of patients undergoing both aseptic (GIQLI - 112.9±1.3 points) and infected (GIQLI - 108.8±2.2 points) destructive complications of severe pancreatitis is lower (p=0...
2016: Khirurgiia
https://www.readbyqxmd.com/read/27769784/vitamin-d3-supplementation-among-adult-patients-with-cystic-fibrosis
#15
Adèle Coriati, Évelyne Labrèche, Marjolaine Mailhot, Hortensia Mircescu, Yves Berthiaume, Annick Lavoie, Rémi Rabasa-Lhoret
BACKGROUND & AIMS: Vitamin D (Vit D) deficiency in cystic fibrosis (CF) is partially secondary to exocrine pancreatic insufficiency. Our aim was to establish a Vit D3 supplementation protocol that will increase 25(OH)D to the recommended level (30 ng/mL). METHODS: Retrospective study of 200 patients (≥18 years) conducted from February 2007 to June 2014 at the CF clinic of the Centre Hospitalier de l'Université de Montréal. Vit D3 supplementation protocol was 1600 IU/day or 10,000 IU/week during the summer (May 1st to October 31st) and 3200 IU/day or 20,000 IU/week during the winter (November 1st to April 30th), in addition to the 1200 IU/day included in multivitamins...
October 8, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27757864/-exocrine-pancreatic-insufficiency-pancreatic-cancer-and-mesenteric-artery-stenosis-a-rare-combination-of-different-diseases-leading-to-an-increasing-frequency-of-diarrhea
#16
Norman Schöffel, Diana Rubin, David A Groneberg, Ralf-Marco Liehr
No abstract text is available yet for this article.
October 2016: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/27757477/-pancreatic-anastomosis-in-operative-treatment-of-chronic-pancreatitis
#17
E Bellon, J R Izbicki, M Bockhorn
Chronic pancreatitis (CP) is an irreversible, inflammatory process, which is characterized by progressive fibrosis of the pancreas and leads to abdominal pain, endocrine and exocrine insufficiency. Surgical therapy is indicated by the absence of pain relief and local complications. The target of the surgical approach is to relieve the pancreatic and bile ducts and resection of the fibrotic and calcified parenchyma. Drainage procedures, such as the Partington-Rochelle method, are used in patients with isolated congestion of the pancreatic duct without further organ complications, such as inflammatory processes of the pancreatic head; however, patients with CP often have an inflammatory swelling of the pancreatic head...
October 18, 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/27748459/exocrine-pancreatic-function-in-children-with-alagille-syndrome
#18
Dorota Gliwicz, Irena Jankowska, Aldona Wierzbicka, Anna Miśkiewicz-Chotnicka, Aleksandra Lisowska, Jarosław Walkowiak
Alagille syndrome (AGS) is often associated with symptoms of maldigestion, such as steatorrhea, hypotrophy and growth retardation. Exocrine pancreatic insufficiency was proposed as the underlying cause. We aimed to assess the exocrine pancreatic function with the use of different methods in AGS patients. Concentrations of fecal elastase-1 (FE1) and fecal lipase (FL) activities were measured in 33 children with AGS. The C-mixed triglyceride breath test (MTBT) in a subgroup comprising 15 patients. In all patients studied, FE1 concentrations and FL activities were normal...
October 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27743711/sarcopenia-is-closely-associated-with-pancreatic-exocrine-insufficiency-in-patients-with-pancreatic-disease
#19
Ryuta Shintakuya, Kenichiro Uemura, Yoshiaki Murakami, Naru Kondo, Naoya Nakagawa, Kazuhide Urabe, Keisuke Okano, Kazuo Awai, Toru Higaki, Taijiro Sueda
BACKGROUND/OBJECTIVES: The loss of skeletal muscle mass (sarcopenia) is associated with the poor prognosis of pancreatic cancer. It has been reported pancreatic exocrine insufficiency (PEI) is associated with serum nutritional markers in chronic pancreatitis. However, there has been no report about the relationship between sarcopenia and PEI. The aim of this study is to determine whether body composition, including skeletal muscle (SM), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), intramuscular adipose tissue content (IMAC), and serum nutritional markers are associated with pancreatic exocrine function in patients with pancreatic disease...
October 11, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27726974/pancreatic-exocrine-insufficiency-after-pancreaticoduodenectomy-is-more-prevalent-with-pancreaticogastrostomy-than-with-pancreaticojejunostomy-a-retrospective-multicentre-observational-cohort-study
#20
Geert Roeyen, Miet Jansen, Laure Ruyssinck, Thiery Chapelle, Aude Vanlander, Bart Bracke, Vera Hartman, Dirk Ysebaert, Frederik Berrevoet
OBJECTIVE: Recently, pancreaticogastrostomy (PG) has attracted renewed interest as a reconstruction technique after pancreaticoduodenectomy (PD), as it may imply a lower risk of clinical pancreatic fistula than reconstruction by pancreaticojejunostomy (PJ). We hypothesise that pancreatic exocrine insufficiency (PEI) is more common during clinical follow-up after PG than it is after PJ. RESEARCH DESIGN AND METHODS: This study compares the prevalence of PEI in patients undergoing PD for malignancy with reconstruction by PG versus reconstruction by PJ...
October 7, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
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