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Alain Carpentier, Christian Latrémouille, Bernard Cholley, David M Smadja, Jean-Christian Roussel, Elodie Boissier, Jean-Noël Trochu, Jean-Pierre Gueffet, Michèle Treillot, Philippe Bizouarn, Denis Méléard, Marie-Fazia Boughenou, Olivier Ponzio, Marc Grimmé, Antoine Capel, Piet Jansen, Albert Hagège, Michel Desnos, Jean-Noël Fabiani, Daniel Duveau
BACKGROUND: The development of artificial hearts in patients with end-stage heart disease have been confronted with the major issues of thromboembolism or haemorrhage. Since valvular bioprostheses are associated with a low incidence of these complications, we decided to use bioprosthetic materials in the construction of a novel artificial heart (C-TAH). We report here the device characteristics and its first clinical applications in two patients with end-stage dilated cardiomyopathy. The aim of the study was to evaluate safety and feasibility of the CARMAT TAH for patients at imminent risk of death from biventricular heart failure and not eligible for transplant...
October 17, 2015: Lancet
Christian Latrémouille, Daniel Duveau, Bernard Cholley, Luca Zilberstein, Guillaume Belbis, Marie-Fazia Boughenou, Denis Meleard, Patrick Bruneval, Clovis Adam, Arthur Neuschwander, Jean-Christophe Perles, Piet Jansen, Alain Carpentier
OBJECTIVES: The Carmat bioprosthetic total artificial heart (TAH) contains bioprosthetic blood-contacting surfaces, and is designed for orthotopic cardiac replacement. In preparation for clinical studies, we evaluated the TAH performance and its effects on end-organ function in an animal model. METHODS: Twelve female Charolais calves, 2-3 months of age and weighing 102-122 kg, were implanted with the TAH through a mid-sternotomy to ensure an adequate anatomic fit...
May 2015: European Journal of Cardio-thoracic Surgery
Paul Mohacsi, Pascal Leprince
No abstract text is available yet for this article.
December 2014: European Journal of Cardio-thoracic Surgery
Joël Ménard
No abstract text is available yet for this article.
February 2014: Médecine Sciences: M/S
Piet Jansen, Willem van Oeveren, Antoine Capel, Alain Carpentier
OBJECTIVES: The CARMAT total artificial heart (TAH) is an implantable, electro-hydraulically driven, pulsatile flow device with four bioprosthetic valves. Its blood-pumping surfaces consist of processed bioprosthetic pericardial tissue and expanded polytetrafluorethylene (ePTFE), potentially allowing for the reduction of anti-coagulation. This pre-clinical study assessed the in vitro haemocompatibility of these surfaces. METHODS: Coupons of pericardial tissue and ePTFE were placed in closed tubular circuits filled with 12...
June 2012: European Journal of Cardio-thoracic Surgery
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