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Tumour diagnosis

Litao Yan, Junwei Zong, Jin Chu, Wendong Wang, Mingshu Li, Xianfeng Wang, Mingzhi Song, Shouyu Wang
The calcaneus is a rare location for the occurrence and development of primary tumour types. Clinicians are unfamiliar with calcaneal tumour types, which may result in a delay in diagnosis or a missed diagnosis, resulting in unnecessary morbidity and amputation. Heel pain and localized swelling of the ankle are the most common symptoms. X-ray is the first choice for a tentative diagnosis of a calcaneal tumour. The final diagnosis depends on a histological examination. The treatment of calcaneal tumour types varies depending on the Enneking system...
June 2018: Oncology Letters
Arnas Bakavičius, Marija Barisienė, Marius Snicorius, Dileta Valančienė, Darius Dasevičius, Algirdas Žalimas, Robertas Kvaščevičius, Henrikas Ramonas, Vitalijus Sokolovas, Feliksas Jankevičius
Introduction: Mixed epithelial and stromal tumour of the kidney (MEST) is a rare and distinctive neoplasm accounting for 0.2% of all renal cancers. Most of these tumours behave in a benign fashion but 13 cases with malignant transformation have already been reported. We present the first case of an extremely aggressive MEST with rapid recurrence after radical treatment, demonstrating objective response to chemotherapy. Case presentation: A 31-year-old female presented to the hospital complaining of gross hematuria...
2018: Acta Medica Lituanica
Monika Kapitančukė, Agnija Vaščiūnaitė, Rasa Augustinienė, Jūratė Sakalinskienė, Gražina Kleinotienė
Background: Primary tumours of the gastrointestinal tract are very uncommon in children. They can present with anaemia caused by gastrointestinal acute or chronic bleeding. One of the most common gastrointestinal tumours is Burkitt lymphoma. This lymphoma is a highly aggressive, rapidly growing B-cell neoplasm, making survival without treatment possible only for a few weeks. For this reason it requires immediate hospitalization and treatment. Case report: We report a case of a gastric Burkitt lymphoma in an adolescent girl who presented with anaemia due to gastrointestinal bleeding...
2018: Acta Medica Lituanica
Sang Mi Chung, Ju Whan Choi, Young Seok Lee, Jong Hyun Choi, Jee Youn Oh, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Jae Jeong Shim, Kyung Ho Kang
BACKGROUND: Bronchoscopy is a useful diagnostic and therapeutic tool. However, the clinical use of high-flow nasal cannula (HFNC) in adults with acute respiratory failure for diagnostic and invasive procedures has not been well evaluated. We present our experiences of well-tolerated diagnostic bronchoscopy as well as cases of improved saturation in hypoxaemic patients after a therapeutic bronchoscopic procedure. METHODS: We retrospectively reviewed data of hypoxaemic patients who had undergone bronchoscopy for diagnostic or therapeutic purposes from October 2015 to February 2017...
June 19, 2018: Tuberculosis and Respiratory Diseases
Laura V Danai, Ana Babic, Michael H Rosenthal, Emily A Dennstedt, Alexander Muir, Evan C Lien, Jared R Mayers, Karen Tai, Allison N Lau, Paul Jones-Sali, Carla M Prado, Gloria M Petersen, Naoki Takahashi, Motokazu Sugimoto, Jen Jen Yeh, Nicole Lopez, Nabeel Bardeesy, Carlos Fernandez-Del Castillo, Andrew S Liss, Albert C Koong, Justin Bui, Chen Yuan, Marisa W Welch, Lauren K Brais, Matthew H Kulke, Courtney Dennis, Clary B Clish, Brian M Wolpin, Matthew G Vander Heiden
Malignancy is accompanied by changes in the metabolism of both cells and the organism1,2 . Pancreatic ductal adenocarcinoma (PDAC) is associated with wasting of peripheral tissues, a metabolic syndrome that lowers quality of life and has been proposed to decrease survival of patients with cancer3,4 . Tissue wasting is a multifactorial disease and targeting specific circulating factors to reverse this syndrome has been mostly ineffective in the clinic5,6 . Here we show that loss of both adipose and muscle tissue occurs early in the development of pancreatic cancer...
June 20, 2018: Nature
Christina M Lovato, Patricia L Kapsner
A 22-year-old woman presented with worsening vision loss and headaches. A diagnosis of acromegaly was confirmed after detection of an invasive pituitary macroadenoma and biochemical testing. Despite two attempts of surgical debulking of the tumour and administration of long-acting octreotide and cabergoline, growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels were uncontrolled. The patient experienced persistent headaches despite surgery, gamma knife radiation and ventriculoperitoneal shunt placement; she was then enrolled in the ACCESS trial (ClinicalTrials...
June 19, 2018: BMJ Case Reports
Aanchal Kakkar, Pirabu Sakthivel, Swati Mahajan, Alok Thakar
Nasopharyngeal adenocarcinomas are rare tumours, and include neoplasms arising from the nasopharyngeal surface epithelium as well as those of minor salivary gland origin, each of which is distinct from the other. The former encompasses nasopharyngeal papillary adenocarcinoma (NPAC), also known as low grade NPAC and thyroid-like NPAC, an extremely unusual malignancy bearing histomorphological similarity to papillary thyroid carcinoma, and displaying indolent clinical behaviour. We report the case of a 41-year-old lady who developed NPAC as a second malignancy five-and-a-half years after being diagnosed and treated for a diffuse astrocytoma in the frontal lobe...
June 19, 2018: Head and Neck Pathology
Sofia C Nunes, Filipa Lopes-Coelho, Sofia Gouveia-Fernandes, Cristiano Ramos, Sofia A Pereira, Jacinta Serpa
BACKGROUND: Ovarian cancer is the second most common gynaecologic malignancy and the most common cause of death from gynaecologic cancer, especially due to diagnosis at an advanced stage, when a cure is rare. As ovarian tumour grows, cancer cells are exposed to regions of hypoxia. Hypoxia is known to be partially responsible for tumour progression, metastasis and resistance to therapies. These suggest that hypoxia entails a selective pressure in which the adapted cells not only have a fitness increase under the selective environment, but also in non-selective adverse environments...
June 19, 2018: BMC Evolutionary Biology
Jemma A Moody, Kamran Ahmed, Tet Yap, Suks Minhas, Majid Shabbir
OBJECTIVES: To determine the impact of testicular cancer and its treatments on fertility and to review the current management options for the infertile, testicular cancer patient, both before diagnosis and after treatment, with the aim to provide practical recommendations to update contemporary guidelines and standardise clinical practice. PATIENTS AND METHODS: Searches for relevant articles on Pubmed and Google Scholar between 2000-2017, with additional articles sourced from reference lists of included publications...
June 19, 2018: BJU International
A Loglio, M Iavarone, G Grossi, M Viganò, M G Rumi, F Facchetti, G Lunghi, A Sangiovanni, M Colombo, P Lampertico
BACKGROUND: Long-term oral nucleos(t)ide analogue (NUC) therapy in hepatitis B virus (HBV)-related compensated cirrhotics prevents clinical decompensation but not hepatocellular carcinoma (HCC) development. AIMS: To define the clinical features and outcomes of HCC in long-term NUC-treated HBV patients. METHODS: All HCCs developing between 2005 and 2016 in NUC-treated HBV patients under surveillance were studied, excluding those that occurred within the first 6 months of therapy...
June 19, 2018: Alimentary Pharmacology & Therapeutics
Sarah Emmett, David C Whiteman, Benedict J Panizza, Annika Antonsson
Squamous cell carcinoma of mucosal sites in the head and neck (HNSCC) is the sixth most common cause of cancer worldwide, and despite advances in conventional management, it still has significant morbidity and mortality associated with both diagnosis and treatment. Advances in our understanding of the biological mechanisms underlying this disease have demonstrated a significant difference between human papillomavirus (HPV)-associated, HPV and tobacco associated, and HPV-negative disease. It remains important to further elucidate the biologic and genetic differences between HPV-associated and tobacco-associated disease, with the aim of earlier diagnosis through screening, and advances in management including the development of novel therapeutic agents...
June 19, 2018: Oncology
Jean E Goasguen, John M Bennett, Barbara J Bain, Richard Brunning, Maria-Teresa Vallespi, Masao Tomonaga, Gina Zini, Alain Renault
An evaluation of the significance of specified dyserythropoietic features in suspected myelodysplastic syndrome (MDS) and acute myeloid leukaemia with erythroid dysplasia was made by means of evaluation of 100 electronic images of bone marrow erythroblasts from each of 20 subjects: 11 with a myeloid neoplasm, six with another condition that could cause erythroid dysplasia and three healthy controls. The evaluation was carried out independently by seven experienced haematologists/haematopathologists who were blinded to the diagnosis...
June 19, 2018: British Journal of Haematology
Adithya Varma, David Giraldi, Samantha Mills, Andrew R Brodbelt, Michael D Jenkinson
BACKGROUND: Intracranial subependymomas account for 0.2-0.7% of central nervous system tumours and are classified as World Health Organization (WHO) grade 1 tumours. They are typically located within the ventricular system and are detected incidentally or with symptoms of hydrocephalus. Due to paucity of studies exploring this tumour type, the objective was to determine the medium- to long-term outcome of intracranial subependymoma treated by surgical resection. METHODS: Retrospective case note review of adults with intracranial WHO grade 1 subependymoma diagnosed between 1990 and 2015 at the Walton Centre NHS Foundation Trust was undertaken...
June 18, 2018: Acta Neurochirurgica
Lorena Losi, Laura Botticelli, Gianluca Taccagni, Ernesto Longinotti, Cesare Lancellotti, Letizia Scurani, Gian Franco Zannoni
We report a case of a 59-year-old woman with peritoneal malignant mesothelioma and no previous exposure to asbestos with a diagnosis of bilateral ovarian serous borderline tumour with peritoneal implants one year before. We discuss the histopathological and immunohistochemical findings to explain possible and potential interactions between the two diseases. To our knowledge, the association of both serous borderline ovarian tumour and malignant peritoneal mesothelioma has never been described before in the same woman and in such a tight temporal connection...
May 2018: Gynecologic Oncology Reports
Suria Hussin, Siti Suhaila Mohd Yusoff, Faridah Mohd Zin, Ab Rahman Izaini Ghani
Frontal meningioma is often asymptomatic and patient may present with psychiatric symptoms. We report a case of 45- year-old female patient with no premorbid medical illness presented with 6 months history of depressive symptoms and changes in personality. Her worsening cognitive impairment brought her to psychiatry clinic and led to further investigation with contrast-enhanced computed tomography (CECT) Brain. The result showed well defined markedly enhancing lesion in the frontal region measuring 5.5 cm X5...
January 2018: Journal of Family Medicine and Primary Care
Christoffer Soendergaard, Jakob Benedict Seidelin, Casper Steenholdt, Ole Haagen Nielsen
Objectives: Characterise the circulating inflammatory cytokine pattern among patients failing consecutive anti-tumour necrosis factor (anti-TNF) and anti-integrin treatments to identify predictors of response. Methods: A retrospective single-centre cohort study of 28 patients with inflammatory bowel disease (IBD) receiving anti-integrin therapy (vedolizumab) subsequent to the failure of anti-TNF treatment was conducted. Blood samples were obtained immediately prior to initiation of vedolizumab therapy, and the response to treatment was evaluated after completion of the 14-week induction regimen...
2018: BMJ Open Gastroenterology
Bruce Gao, Emeka Nzekwu, Anthony Jonathan Cook, Shelley Jane Spaner
BACKGROUND: Nephroblastomatosis is an uncommon pathologic process characterized by the presence of persistent embryonic nephrogenic rests. Progression to Wilms tumour occurs in an estimated 35% of patients. Cure rates are based on histologic findings and disease stage and have improved from 10% in the 1920s to over 90% today. CASE PRESENTATION: We report a case of a 9-month-old female presenting with a 2-month history of abdominal distension. Ultrasonographic and computed tomographic assessments demonstrated features consistent with bilateral, diffuse, hyperplastic perilobar nephroblastomatosis (DHPLNB) for which she underwent chemotherapy...
June 19, 2018: BMC Research Notes
Philippe Mortelmans, Marie-Christine Herregods, Filip Rega, Philippe Timmermans
BACKGROUND: Development of carcinoid heart disease (CHD) is the major negative prognostic factor in patients with the carcinoid syndrome. The only effective treatment is valve replacement. However, the selection of candidates and determination of optimal timing remain unclear. Considerable variability in local screening and treatment strategies exist. METHODS: In this single-centre study, we retrospectively analysed the diagnostic process and outcome of all CHD patients who underwent valve surgery between 2000 and 2016...
June 18, 2018: Acta Cardiologica
Sara Kammerer, Monika Mueller-Eschner, Arne Lauer, Anna-Luisa Luger, Johanna Quick-Weller, Kea Franz, Patrick Harter, Joachim Berkefeld, Marlies Wagner
PURPOSE:  Intracranial subependymomas are rare, mostly asymptomatic tumours, which are often found incidentally and therefore did not receive much attention in previous literature. By being classified as benign grade I in the WHO classification of tumours of the central nervous system, they are given a special status compared to the other ependymal tumours. Tumor recurrences are a rarity, spinal "drop metastases" do not occur. While etiological, pathological and therapeutic characteristics have been subject of several publications over the last few decades and have meanwhile been well studied, the imaging characteristics are much less well received...
June 18, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Emre Demirci, Levent Kabasakal, Turkay Toklu, Meltem Ocak, Onur E Şahin, Nalan Alan-Selcuk, Ahmet Araman
PURPOSE: Upon diagnosis, distant metastases are encountered in 21-50% of neuroendocrine tumours (NETs). However, few systemic treatment options are available for the well-differentiated NETs in the metastatic stage. Lu-DOTATATE is one of the most effective treatments in this limited patient group. We retrospectively investigated its efficacy and effect on the survival in patients with both well-differentiated and grade III NETs who had high uptake in pretherapeutic Ga-DOTATATE PET/computed tomography scans...
June 15, 2018: Nuclear Medicine Communications
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