keyword
https://read.qxmd.com/read/37600289/aspartate-and-acetate-fuel-gastrointestinal-stromal-tumors-beyond-the-warburg-effect
#21
JOURNAL ARTICLE
Ying-Chieh Lai, Gigin Lin, Kung-Chu Ho, Kuan-Ying Lu, Cheng-Kun Tsai, Cheng-Yu Hung, Ta-Sen Yeh
UNLABELLED: Metabolic reprogramming is closely linked to the tumorigenesis and drug resistance of gastrointestinal stromal tumors (GISTs). Mapping the metabolic orbit of GISTs is a prerequisite if intervention against the metabolic vulnerability of refractory GISTs is desirable. METHODS: A total of 43 patients with treatment-naïve GISTs who had undergone surgical resections were enrolled, on whom a metabolomics profile detected from surgical specimens was constructed based on the 1 H-nuclear magnetic resonance (NMR) platform...
December 2022: Annals of surgery open: perspectives of surgical history, education, and clinical approaches
https://read.qxmd.com/read/37597228/-small-intestinal-hemorrhage-in-a-patient-with-neurofibromatosis-type-1
#22
JOURNAL ARTICLE
Katia Gesell Guevara-Peralta, Nilton Fidel Zegarra-Neira, Rosa Fabiola Bayro-Peñaloza
We present the case of a 32-year-old male patient with a history of Neurofibromatosis type 1, who presented with active small bowel bleeding, initially diagnosed by observing bleeding in ileoscopy, presenting with hemodynamic instability, abdominal angiotomography was performed, identifying a mass with contrast enhancement and active bleeding at the middle jejunum level, for which an angiography with arterial embolization of the branch that supplies said area is performed. With the patient stable, a double-balloon antegrade enteroscopy was performed, observing a subepithelial, ulcerated lesion, endoscopic tattooing was performed and finally surgery was sent for resection by laparoscopy...
2023: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://read.qxmd.com/read/37500390/radiotherapy-in-the-management-of-rare-gastrointestinal-cancers-a-systematic-review
#23
REVIEW
F Z Bellefkih, N Benchakroun, I Lalya, B Amaoui, H El Kacemi, A Acharki, M El Hfid, A El Mazghi, T Chekrine, Z Bouchbika, H Jouhadi, S Sahraoui, N Tawfiq, M Michalet
The aim of this analysis is to assess radiotherapy's role and technical aspects in an array of rare gastrointestinal (GI) cancers for adult patients. Collection data pertaining to radiotherapy and digestive rare cancers were sourced from Medline, EMBASE, and Cochrane Library. Preoperative chemoradiotherapy improved outcomes for patients with esophageal undifferentiated carcinoma compared with esophageal salivary gland types of carcinomas. For rare gastric epithelial carcinoma, perioperative chemotherapy is the common treatment...
September 2023: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://read.qxmd.com/read/37463014/kit-pdgfra-variant-allele-frequency-as-prognostic-factor-in-gastrointestinal-stromal-tumors-gists-results-from-a-multi-institutional-cohort-study
#24
JOURNAL ARTICLE
Lorena Incorvaia, Dario De Biase, Margherita Nannini, Elena Fumagalli, Bruno Vincenzi, Ida De Luca, Chiara Brando, Alessandro Perez, Maria A Pantaleo, Silvia Gasperoni, Lorenzo D'Ambrosio, Giovanni Grignani, Thais Maloberti, Erika Pedone, Tancredi Didier Bazan Russo, Alessandro Mazzocca, Laura Algeri, Alessandra Dimino, Nadia Barraco, Roberta Serino, Valerio Gristina, Antonio Galvano, Viviana Bazan, Antonio Russo, Giuseppe Badalamenti
BACKGROUND: The patient selection for optimal adjuvant therapy in gastrointestinal stromal tumors (GISTs) is provided by nomogram based on tumor size, mitotic index, tumor location, and tumor rupture. Although mutational status is not currently used to risk assessment, tumor genotype showed a prognostic influence on natural history and tumor relapse. Innovative measures, such as KIT/PDGFRA-mutant-specific variant allele frequency (VAF) levels detection from next-generation sequencing (NGS), may act as a surrogate of tumor burden and correlate with prognosis and overall survival of patients with GIST, helping the choice for adjuvant treatment...
July 18, 2023: Oncologist
https://read.qxmd.com/read/37455549/the-rare-entity-of-gastrointestinal-leiomyosarcomas-an-italian-multicenter-retrospective-study-in-high-volume-referral-centers
#25
JOURNAL ARTICLE
Paola Zagami, Alessandro Comandone, Marco Fiore, Giacomo Giulio Baldi, Giovanni Grignani, Bruno Vincenzi, Alessandro Gronchi, Gabriele Antonarelli, Antonella Boglione, Elisabetta Pennacchioli, Giuseppe Curigliano, Fabio Conforti, Tommaso Martino De Pas
BACKGROUND: After a huge efficacy of imatinib in treating patients with gastrointestinal stromal tumors (GISTs) was proven, a maximum effort was made to make a differential diagnosis between GISTs and gastrointestinal leiomyosarcomas (GI-LMS), showing the latter to be an extremely rare tumor entity. Limited data on GI-LMS biology, clinical behavior and drug-sensibility are available, and the clinical decision-making in this subgroup of patients is usually challenging. METHODS: We conducted a multicenter, retrospective observational study on patients with diagnosed GI-LMS from 2004 to 2020 within six high-volume referral centers in Italy...
July 16, 2023: Cancer Medicine
https://read.qxmd.com/read/37315115/molecular-advances-in-the-treatment-of-advanced-gastrointestinal-stromal-tumor
#26
JOURNAL ARTICLE
Vinayak Venkataraman, Suzanne George, Gregory M Cote
Most gastrointestinal stromal tumors (GIST) are driven by activating mutations in Proto-oncogene c-KIT (KIT) or PDGFRA receptor tyrosine kinases (RTK). The emergence of effective therapies targeting these mutations has revolutionized the management of advanced GIST. However, following initiation of first-line imatinib, a tyrosine kinase inhibitor (TKI), nearly all patients will develop resistance within 2 years through the emergence of secondary resistance mutations in KIT, typically in the Adenosine Triphosphate (ATP)-binding site or activation loop of the kinase domain...
June 14, 2023: Oncologist
https://read.qxmd.com/read/37302758/the-multifaceted-landscape-behind-imatinib-resistance-in-gastrointestinal-stromal-tumors-gists-a-lesson-from-ripretinib
#27
REVIEW
Aldo Di Vito, Gloria Ravegnini, Francesca Gorini, Trond Aasen, Cesar Serrano, Eva Benuzzi, Emma Coschina, Sarah Monesmith, Fabiana Morroni, Sabrina Angelini, Patrizia Hrelia
Gastrointestinal stromal tumors (GISTs) are rare mesenchymal sarcomas and the gold-standard treatment is represented by tyrosine kinase inhibitors (TKIs). Unfortunately, first-line treatment with the TKI imatinib usually promotes partial response or stable disease rather than a complete response, and resistance appears in most patients. Adaptive mechanisms are immediately relevant at the beginning of imatinib therapy, and they may represent the reason behind the low complete response rates observed in GISTs...
June 9, 2023: Pharmacology & Therapeutics
https://read.qxmd.com/read/37296838/measuring-tumour-imatinib-concentrations-in-gastrointestinal-stromal-tumours-relevant-or-redundant
#28
JOURNAL ARTICLE
Eline L Giraud, Loek A W de Jong, Erik van den Hombergh, Suzanne E J Kaal, Nielka P van Erp, Ingrid M E Desar
Imatinib plasma trough concentrations are associated with efficacy for patients treated for advanced or metastatic KIT-positive gastrointestinal stromal tumours (GISTs). This relationship has not been studied for patients treated in the neoadjuvant setting, let alone its correlation with tumour drug concentrations. In this exploratory study we aimed to determine the correlation between plasma and tumour imatinib concentrations in the neoadjuvant setting, investigate tumour imatinib distribution patterns within GISTs, and analyse its correlation with pathological response...
May 23, 2023: Cancers
https://read.qxmd.com/read/37274561/recent-advances-in-endoscopic-management-of-gastric-neoplasms
#29
REVIEW
Hira Imad Cheema, Benjamin Tharian, Sumant Inamdar, Mauricio Garcia-Saenz-de-Sicilia, Cem Cengiz
The development and clinical application of new diagnostic endoscopic technologies such as endoscopic ultrasonography with biopsy, magnification endoscopy, and narrow-band imaging, more recently supplemented by artificial intelligence, have enabled wider recognition and detection of various gastric neoplasms including early gastric cancer (EGC) and subepithelial tumors, such as gastrointestinal stromal tumors and neuroendocrine tumors. Over the last decade, the evolution of novel advanced therapeutic endoscopic techniques, such as endoscopic mucosal resection, endoscopic submucosal dissection, endoscopic full-thickness resection, and submucosal tunneling endoscopic resection, along with the advent of a broad array of endoscopic accessories, has provided a promising and yet less invasive strategy for treating gastric neoplasms with the advantage of a reduced need for gastric surgery...
May 16, 2023: World Journal of Gastrointestinal Endoscopy
https://read.qxmd.com/read/37240887/development-and-validation-of-artificial-intelligence-based-radiomics-model-using-computed-tomography-features-for-preoperative-risk-stratification-of-gastrointestinal-stromal-tumors
#30
JOURNAL ARTICLE
Marco Rengo, Alessandro Onori, Damiano Caruso, Davide Bellini, Francesco Carbonetti, Domenico De Santis, Simone Vicini, Marta Zerunian, Elsa Iannicelli, Iacopo Carbone, Andrea Laghi
BACKGROUND: preoperative risk assessment of gastrointestinal stromal tumors (GISTS) is required for optimal and personalized treatment planning. Radiomics features are promising tools to predict risk assessment. The purpose of this study is to develop and validate an artificial intelligence classification algorithm, based on CT features, to define GIST's prognosis as determined by the Miettinen classification. METHODS: patients with histological diagnosis of GIST and CT studies were retrospectively enrolled...
April 24, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37223931/anti-tumor-efficacy-of-the-novel-kit-inhibitor-idrx-42-formerly-m4205-in-patient-and-cell-line-derived-xenograft-models-of-gastrointestinal-stromal-tumor-gist
#31
JOURNAL ARTICLE
Luna De Sutter, Agnieszka Wozniak, Jasper Verreet, Ulla Vanleeuw, Lore De Cock, Nina Linde, Christine Drechsler, Christina Esdar, Raf Sciot, Patrick Schöffski
BACKGROUND: The majority of GIST are driven by constitutively activated KIT/PDGFRA kinases and are susceptible to treatment with tyrosine kinase inhibitors. During treatment, most of these tumors will develop secondary mutations in KIT or PDGFRA inducing drug resistance, so there is an unmet need for novel therapies. We tested the efficacy of IDRX-42, a novel selective KIT inhibitor with high activity towards the most relevant KIT mutations, in 4 GIST xenograft models. METHODS: NMRI nu/nu mice were transplanted with patient-derived GIST xenograft models UZLX-GIST9 (KIT:p...
May 24, 2023: Clinical Cancer Research
https://read.qxmd.com/read/37170590/learning-curve-for-endoscopic-resection-of-gastric-gastrointestinal-stromal-tumors-a-single-center-experience
#32
JOURNAL ARTICLE
Luojie Liu, Xiaodan Xu, Wendao You, Dongtao Shi, Rui Li, Chao Ma
BackgroundEndoscopic resection (ER) is widely used in the treatment of gastric gastrointestinal stromal tumors (gGISTs). However, no studies have previously described the learning curve (LC) for ER of gGISTs. We aimed to evaluate the LC based on multifarious operative outcomes. MethodsWe included 100 consecutive patients who underwent ER of gGISTs by a single endoscopist from January 2017 to December 2022. Patients were analyzed in groups of 10 to minimize demographic differences and operative time (OT), conversion rate, introperative and postoperative complication were assessed to evaluate the LC...
May 12, 2023: Revista Española de Enfermedades Digestivas
https://read.qxmd.com/read/37114421/mucosal-schwann-cell-hamartoma-a-benign-and-little-known-entity
#33
JOURNAL ARTICLE
Violeta Mauriz Barreiro, Marta Ramos Alonso, Martín Fernández López, Diana Alejandra Rivera Castillo, Cristina Durana Tonder, Carmen Pradera Cibreiro
Dear editor, 50 years-old female with personal history of mutation of the gene BRCA1 and previous prophylactic double anexectomy consulted for rectal bleeding without pain since two weeks. A blood test was performed, with hemoglobin levels of 13.1g/dl and without iron deficiency. In the anal inspection there were neither external hemorrhoids nor anal fistulas, so a colonoscopy was requested. In the colonoscopy, all the colon mucosa was normal but, in the rectal retroflexion, apart from internal engorged hemorrhoids, surrounding the 50% of the anal opening an erythematous and indurated mucosa was found (figure 1)...
April 28, 2023: Revista Española de Enfermedades Digestivas
https://read.qxmd.com/read/37108337/lix1-controls-mapk-signaling-reactivation-and-contributes-to-gist-t1-cell-resistance-to-imatinib
#34
JOURNAL ARTICLE
Salomé Ruiz-Demoulin, Eva Trenquier, Sanaa Dekkar, Sébastien Deshayes, Prisca Boisguérin, César Serrano, Pascal de Santa Barbara, Sandrine Faure
Gastrointestinal stromal tumor (GIST), the most common sarcoma, is mainly caused by an oncogenic mutation in the KIT receptor tyrosine kinase. Targeting KIT using tyrosine kinase inhibitors, such as imatinib and sunitinib, provides substantial benefit; however, in most patients, the disease will eventually progress due to KIT secondary mutations leading to treatment failure. Understanding how GIST cells initially adapt to KIT inhibition should guide the selection of appropriate therapies to overcome the emergence of resistance...
April 12, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37059834/dabrafenib-plus-trametinib-in-brafv600e-mutated-rare-cancers-the-phase-2-roar-trial
#35
JOURNAL ARTICLE
Vivek Subbiah, Robert J Kreitman, Zev A Wainberg, Anas Gazzah, Ulrik Lassen, Alexander Stein, Patrick Y Wen, Sascha Dietrich, Maja J A de Jonge, Jean-Yves Blay, Antoine Italiano, Kan Yonemori, Daniel C Cho, Filip Y F L de Vos, Philippe Moreau, Elena Elez Fernandez, Jan H M Schellens, Christoph C Zielinski, Suman Redhu, Aislyn Boran, Vanessa Q Passos, Palanichamy Ilankumaran, Yung-Jue Bang
BRAFV600E alterations are prevalent across multiple tumors. Here we present final efficacy and safety results of a phase 2 basket trial of dabrafenib (BRAF kinase inhibitor) plus trametinib (MEK inhibitor) in eight cohorts of patients with BRAFV600E-mutated advanced rare cancers: anaplastic thyroid carcinoma (n = 36), biliary tract cancer (n = 43), gastrointestinal stromal tumor (n = 1), adenocarcinoma of the small intestine (n = 3), low-grade glioma (n = 13), high-grade glioma (n = 45), hairy cell leukemia (n = 55) and multiple myeloma (n = 19)...
April 14, 2023: Nature Medicine
https://read.qxmd.com/read/37038981/the-patient-s-perspective-on-side-effects-of-tyrosine-kinase-inhibitors-in-the-treatment-of-advanced-and-metastatic-gastrointestinal-stromal-tumors
#36
JOURNAL ARTICLE
Deborah van de Wal, Shreenila Venkatesan, Charlotte Benson, Winette Ta van der Graaf, Colin D Johnson, Olga Husson, Samantha C Sodergren
Aim: To provide the gastrointestinal stromal tumor patient's perspective on side effects of tyrosine kinase inhibitors and compare this with that of healthcare professionals. Materials & methods: Semi-structured interviews were conducted with 19 patients with an advanced or metastatic gastrointestinal stromal tumor, as well as six healthcare professionals, and five patients participated in a focus group. Thematic analysis was used to interpret the data. Results : Most participants (n = 29) reported gastrointestinal symptoms followed by tiredness (n = 25), edema (n = 22), muscle cramps (n = 21), skin problems (n = 21), eye problems (n = 11) and trouble sleeping (n = 10)...
April 11, 2023: Future Oncology
https://read.qxmd.com/read/37008525/endoscopic-submucosal-dissection-for-subepithelial-tumor-treatment-in-the-upper-digestive-tract-a-western-multicenter-study
#37
JOURNAL ARTICLE
Raffaele Manta, Francesco Paolo Zito, Francesco Pugliese, Angelo Caruso, Santi Mangiafico, Alessandra D'Alessandro, Danilo Castellani, Ugo Germani, Massimiliano Mutignani, Rita Luisa Conigliaro, Luca Reggiani Bonetti, Takahisa Matsuda, Vincenzo De Francesco, Angelo Zullo, Giuseppe Galloro
BACKGROUND/AIMS: Endoscopic submucosal dissection (ESD) has been proposed for removal of gastrointestinal subepithelial tumors (GI-SETs), but data are still scanty. This study aimed to report a case series from a western country. PATIENTS AND METHODS: Data of patients with upper GI-SETs suitable for ESD removal observed in 4 centers were retrospectively reviewed. Before endoscopic procedure, the lesion was characterized by endosonographic evaluation, histology, and CT scan...
March 2023: GE Portuguese Journal of Gastroenterology
https://read.qxmd.com/read/36978244/changes-in-survival-in-de-novo-metastatic-cancer-in-an-era-of-new-medicines
#38
JOURNAL ARTICLE
Marianne Luyendijk, Otto Visser, Hedwig M Blommestein, Ignace H J T de Hingh, Frank J P Hoebers, Agnes Jager, Gabe S Sonke, Elisabeth G E de Vries, Carin A Uyl-de Groot, Sabine Siesling
BACKGROUND: Over the past decades, the therapeutic landscape has markedly changed for patients with metastatic solid cancer, yet few studies have evaluated its effect on population-based survival. The objective of this study was to evaluate the change in survival of patients with de novo metastatic solid cancers during the last 30 years. METHODS: For this retrospective study, data from almost 2 million patients diagnosed with a solid cancer between January 1, 1989, and December 31, 2018, were obtained from the Netherlands Cancer Registry, with follow-up until January 31, 2021...
June 8, 2023: Journal of the National Cancer Institute
https://read.qxmd.com/read/36925325/nephrotic-syndrome-as-a-manifestation-of-thrombotic-microangiopathy-due-to-long-term-use-of-sunitinib
#39
John Fredy Nieto-Ríos, Camilo Andrés García-Prada, Arbey Aristizabal-Alzate, Gustavo Zuluaga-Valencia, Dahyana Cadavid-Aljure, Lina Maria Serna-Higuita, Luis F Arias
Nephrotic syndrome in patients with cancer may be related to the primary malignancy or chemotherapeutic therapy. Solid organ cancers may cause membranous glomerulonephritis which is manifested by nephrotic syndrome; other less common histologic presentations include focal and segmental glomerulosclerosis and minimal change disease. In addition, chemotherapy agents may cause renal toxicity by affecting the small blood vessels, glomeruli, tubules, and interstitium. Tyrosine kinase inhibitors such as sunitinib may cause endothelial and podocyte damage leading to thrombotic microangiopathy affecting only the kidney and manifested by proteinuria and hypertension...
March 14, 2023: Nefrología
https://read.qxmd.com/read/36868311/mimicking-tumor-cell-heterogeneity-of-colorectal-cancer-in-a-patient-derived-organoid-fibroblast-model
#40
JOURNAL ARTICLE
Velina S Atanasova, Crhistian de Jesus Cardona, Václav Hejret, Andreas Tiefenbacher, Theresia Mair, Loan Tran, Janette Pfneissl, Kristina Draganić, Carina Binder, Julijan Kabiljo, Janik Clement, Katharina Woeran, Barbara Neudert, Sabrina Wohlhaupter, Astrid Haase, Sandra Domazet, Markus Hengstschläger, Markus Mitterhauser, Leonhard Müllauer, Boris Tichý, Michael Bergmann, Gabriele Schweikert, Markus Hartl, Helmut Dolznig, Gerda Egger
BACKGROUND & AIMS: Patient-derived organoid cancer models are generated from epithelial tumor cells and reflect tumor characteristics. However, they lack the complexity of the tumor microenvironment, which is a key driver of tumorigenesis and therapy response. Here, we developed a colorectal cancer organoid model that incorporates matched epithelial cells and stromal fibroblasts. METHODS: Primary fibroblasts and tumor cells were isolated from colorectal cancer specimens...
March 1, 2023: Cellular and Molecular Gastroenterology and Hepatology
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