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tumor de gist

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https://www.readbyqxmd.com/read/28024574/mirna-218-loaded-carboxymethyl-chitosan-tocopherol-nanoparticle-to-suppress-the-proliferation-of-gastrointestinal-stromal-tumor-growth
#1
Lin Tu, Ming Wang, Wen-Yi Zhao, Zi-Zhen Zhang, De-Feng Tang, Ye-Qian Zhang, Hui Cao, Zhi-Gang Zhang
Gastrointestinal stromal tumors (GIST) are one of the most common forms of mesenchymal cancers of the gastrointestinal tract. Although chemotherapeutic drugs inhibited the proliferation of GIST, however, sizable proportion of people developed resistance and therefore difficult to treat. In the present study, O-carboxymethyl chitosan (OCMC)-tocopherol polymer conjugate was synthesized and formulated into stable polymeric nanoparticles. The main aim of present study was to increase the therapeutic efficacy of miR-218 in GIST...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27981619/familial-progressive-hyperpigmentation-cutaneous-mastocytosis-and-gastrointestinal-stromal-tumor-as-clinical-manifestations-of-mutations-in-the-c-kit-receptor-gene
#2
Tatiana Piqueres-Zubiaurre, Zuriñe Martínez de Lagrán, Ricardo González-Pérez, Amaia Urtaran-Ibarzabal, Guiomar Perez de Nanclares
BACKGROUND: Familial progressive hyperpigmentation (FPH) is an autosomal dominant disorder characterized by the appearance of hyperpigmented patches on the skin from early infancy that increase in size and number with age. METHODS: We report the clinical and molecular studies of an 11-year-old boy who had areas of hyperpigmentation since birth that had spread across his body as irregular hyperpigmented macules and papules, and include relevant history in family members...
December 16, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27974047/fgfr1-and-ntrk3-actionable-alterations-in-wild-type-gastrointestinal-stromal-tumors
#3
Eileen Shi, Juliann Chmielecki, Chih-Min Tang, Kai Wang, Michael C Heinrich, Guhyun Kang, Christopher L Corless, David Hong, Katherine E Fero, James D Murphy, Paul T Fanta, Siraj M Ali, Martina De Siena, Adam M Burgoyne, Sujana Movva, Lisa Madlensky, Gregory M Heestand, Jonathan C Trent, Razelle Kurzrock, Deborah Morosini, Jeffrey S Ross, Olivier Harismendy, Jason K Sicklick
BACKGROUND: About 10-15% of adult, and most pediatric, gastrointestinal stromal tumors (GIST) lack mutations in KIT, PDGFRA, SDHx, or RAS pathway components (KRAS, BRAF, NF1). The identification of additional mutated genes in this rare subset of tumors can have important clinical benefit to identify altered biological pathways and select targeted therapies. METHODS: We performed comprehensive genomic profiling (CGP) for coding regions in more than 300 cancer-related genes of 186 GISTs to assess for their somatic alterations...
December 14, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27896638/seom-clinical-guideline-for-gastrointestinal-sarcomas-gist-2016
#4
A Poveda, V Martinez, C Serrano, I Sevilla, M J Lecumberri, R D de Beveridge, A Estival, D Vicente, J Rubió, J Martin-Broto
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the digestive tract, and this disease has served as a paradigmatic model for successful rational development of targeted therapies. The introduction of tyrosine kinase inhibitors with activity against KIT/PDGFRA in both localized and advanced stages has remarkably improved the survival in a disease formerly deemed resistant to all systemic therapies. The Spanish Society of Medical Oncology (SEOM) guidelines provide a multidisciplinary and updated consensus for the diagnosis and treatment of GIST patients...
December 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27855991/-obscure-gastrointestinal-bleeding-due-to-gastrointestinal-stromal-tumors
#5
Larry Romero-Espinosa, Luis Manuel Souza-Gallardo, José Luis Martínez-Ordaz, Teodoro Romero-Hernández, Mauricio de la Fuente-Lira, Jorge Arellano-Sotelo
BACKGROUND: The gastrointestinal stromal tumours (GIST) are the most common soft tissue sarcomas of the digestive tract. They are usually found in the stomach (60-70%) and small intestine (25-30%) and, less commonly, in the oesophagus, mesentery, colon, or rectum. The symptoms present at diagnosis are, gastrointestinal bleeding, abdominal pain, abdominal mass, or intestinal obstruction. The type of symptomatology will depend on the location and size of the tumour. The definitive diagnosis is histopathological, with 95% of the tumours being positive for CD117...
November 14, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27793025/hedgehog-pathway-dysregulation-contributes-to-the-pathogenesis-of-human-gastrointestinal-stromal-tumors-via-gli-mediated-activation-of-kit-expression
#6
Chih-Min Tang, Tracy E Lee, Sabriya A Syed, Adam M Burgoyne, Stephanie Y Leonard, Fei Gao, Jonathan C Chan, Eileen Shi, Juliann Chmielecki, Deborah Morosini, Kai Wang, Jeffrey S Ross, Michael L Kendrick, Michael R Bardsley, Martina De Siena, Junhao Mao, Olivier Harismendy, Tamas Ordog, Jason K Sicklick
Gastrointestinal stromal tumors (GIST) arise within the interstitial cell of Cajal (ICC) lineage due to activating KIT/PDGFRA mutations. Both ICC and GIST possess primary cilia (PC), which coordinate PDGFRA and Hedgehog signaling, regulators of gastrointestinal mesenchymal development. Therefore, we hypothesized that Hedgehog signaling may be altered in human GIST and controls KIT expression. Quantitative RT-PCR, microarrays, and next generation sequencing were used to describe Hedgehog/PC-related genes in purified human ICC and GIST...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27713191/not-ery-small-bowel-submucosal-mass-is-a-gist-a-rare-case-of-small-bowel-schwannoma
#7
Giuseppe Portale, Mariano De Vito, Alberto Morabito, Massimiliano Zuccaro, Valentino Fiscon
INTRODUCTION: Schwannomas are slow-growing tumors, rarely occurring in the GI tract. When found, their location is mostly in the stomach. Presentation in the small bowel is extremely rare, anecdotal. CASE REPORT: We present the case of a 47-year old male who underwent laparoscopic elective left hemicolectomy for recurrent diverticulitis. RESULTS: At surgery an exophytic mass originating from the first jejunal loop was identified and resected, under the suspicion of a GIST...
July 8, 2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27493882/familiar-papillary-thyroid-carcinoma-in-a-large-brazilian-family-is-not-associated-with-succinate-dehydrogenase-defects
#8
Elen Dias Accordi, Paraskevi Xekouki, Bruna Azevedo, Rodrigo Bertollo de Alexandre, Carla Frasson, Siliane Marie Gantzel, Georgios Z Papadakis, Anna Angelousi, Constantine A Stratakis, Vanessa Santos Sotomaior, Fabio R Faucz
BACKGROUND: Thyroid cancer is the most common endocrine gland malignancy. Advances in understanding the genetic basis for thyroid cancer revealed the potential involvement of several genes in the formation of thyroid tumors. Mutations in the gene coding for succinate dehydrogenase subtype B (SDHB) have been implicated in papillary thyroid cancer (PTC). Succinate dehydrogenase (SDH) is a heterotetrameric protein composed of four subunits, SDHA, SDHB, SDHC, and SDHD, and participates in both the electron transport chain and the tricarboxylic acid cycle...
July 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27459214/how-can-endoscopic-r0-resection-be-ensured-for-relatively-small-gastric-gastrointestinal-stromal-tumors
#9
Qiang Zhang, Si-De Liu
No abstract text is available yet for this article.
August 2016: Endoscopy
https://www.readbyqxmd.com/read/27358721/phosphorylated-insulin-growth-factor-i-receptor-p-igf1r-and-metalloproteinase-3-mmp3-expression-in-advanced-gastrointestinal-stromal-tumors-gist-a-geis-19-study
#10
Joan Maurel, Antonio López-Pousa, Silvia Calabuig, Silvia Bagué, Xavier Garcia Del Muro, Xavier Sanjuan, Jordi Rubió-Casadevall, Miriam Cuatrecasas, Javier Martinez-Trufero, Carlos Horndler, Joaquin Fra, Claudia Valverde, Andrés Redondo, Andrés Poveda, Isabel Sevilla, Nuria Lainez, Michele Rubini, Xabier García-Albéniz, Javier Martín-Broto, Enrique de Alava
BACKGROUND: Most GISTs have mutations in KIT or PDGFRA. Patients with advanced GIST with KIT exon 9, PDGFRA mutation or WT for KIT and PDGFRA have a worse progression-free survival (PFS) compared to patients with KIT exon 11 mutated tumors. We evaluated the immunohistochemical (IHC) expression of p-IGF1R (Y1316) and MMP3 as predictors of PFS or overall survival (OS). METHODS: Ninety-two advanced GIST patients included in GEIS-16 study with KIT and PDGFRA mutational information were examined for p-IGF1R (Y1316) and MMP3 expression in a tissue micro-array...
2016: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/27356148/pancreas-preserving-surgery-for-duodenal-gastrointestinal-stromal-tumor-removal
#11
Daniele Crocetti, Paolo Sapienza, Claudio Cisano, Mariarita Tarallo, Andrea Polistena, Luigi Venturini, Giuseppe Pedullà, Giorgio De Toma
BACKGROUND: We reported our experience with high-risk, non-metastatic second portion duodenal gastrointestinal stromal tumor (GIST)s in patients who underwent 1-month neoadjuvant cycles with imatinib therapy followed by pancreas-preserving surgery and 12-month of adjuvant chemotherapic regimen including imatinib. This study was conducted to evaluate the short and long-term results. METHODS: The study was conducted between January 2010 and May 2015. Medical charts and operative logbooks of patients were retrospectively reviewed...
October 2016: Minerva Chirurgica
https://www.readbyqxmd.com/read/27275595/preliminary-analysis-of-hybrid-laparoscopic-procedure-for-resection-of-gastric-submucosal-tumors
#12
Pedro Henrique Lambach Caron, Mariana Ismael Dias Martins, Pedro Luiz Bertevello
OBJECTIVE: to evaluate the feasibility, safety and benefits of minimally invasive surgery for resection of gastric submucosal tumor (GSMT). METHODS: we conducted a retrospective study of medical records of patients undergoing endoscopy-assisted laparoscopic resection of gastric submucosal tumors (prospectively collected) from 2011 to 2014. We evaluated clinical data, surgical approach, clinicopathological characteristics of the GSMT (size, location, histopathological and immunohistochemical exams), outcome and patients follow-up...
March 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/27123077/primary-extragastrointestinal-stromal-tumor-of-the-pleura-a-case-report
#13
Cai-Qing Zhang, DE-Gan Lu, Qing-Fa Liu, Wei Xiao
Gastrointestinal stromal tumors (GISTs) are the most common type of mesenchymal tumor of the gastrointestinal tract. The stomach and small intestine are the most common sites of occurrence. GISTs are mesenchymal neoplasms originating from the interstitial cells of Cajal (ICCs), and are characterized by positivity for cluster of differentiation (CD) 117, also known as proto-oncogene c-Kit. While the majority of GISTs develop in the alimentary tract, in rare cases they may also be found in extragastrointestinal tissues...
May 2016: Oncology Letters
https://www.readbyqxmd.com/read/27120729/laparoscopic-resection-of-gastrointestinal-stromal-tumors-gist
#14
Marcelo de Paula Loureiro, Rômulo Augusto Andrade de Almeida, Christiano Marlo Paggi Claus, Eduardo Aimoré Bonin, Antônio Moris Cury-Filho, Daniellson Dimbarre, Marco Aurélio Raeder da Costa, Marcílio Lisboa Vital
BACKGROUND: Gastrointestinal mesenchymal or stromal tumors (GIST) are lesions originated on digestive tract walls, which are treated by surgical resection. Several laparoscopic techniques, from gastrectomies to segmental resections, have been used successfully. AIM: Describe a single center experience on laparoscopic GIST resection. METHOD: Charts of 15 operated patients were retrospectively reviewed. Thirteen had gastric lesions, of which ten were sub epithelial, ranging from 2-8 cm; and three were pure exofitic growing lesions...
March 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27087954/efficiency-and-safety-of-endoscopic-resection-in-the-management-of-subepithelial-lesions-of-the-stomach
#15
Sébastien Godat, Maxime Robert, Fabrice Caillol, Erwan Bories, Christian Pesenti, Chiara De Cassan, Jean Philippe Ratone, Flora Poizat, Marc Giovannini
BACKGROUND: Gastric subepithelial tumors represent a diagnostic and therapeutic challenge, given their histologic heterogeneity and potential malignant behavior. OBJECTIVE: The objective of this article is to evaluate the interest, efficiency and safety of endoscopic resection for subepithelial gastric lesions of size <20 mm. METHODS: We conducted a single-center retrospective study in a tertiary care center. RESULTS: A total of 33 lesions (10 malignant/23 benign lesions) were studied...
April 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/27073505/gastric-schwannoma-misdiagnosed-as-gist-a-case-report-with-immunohistochemical-and-molecular-study
#16
Fabiana Tatangelo, Monica Cantile, Francesca Collina, Andrea Belli, Silvia DE Franciscis, Franco Bianco, Gerardo Botti
Schwannomas are tumors derived from Schwann cells. Generally, they are benign and their typical site of origin is the subcutaneous tissue of the distal extremities or of the head and neck region. Gastrointestinal localization of schwannomas is extremely rare, and the stomach is the prevalent site. The present study describes the case of a gastric schwannoma in a 61-year-old male who underwent subtotal gastrectomy following a clinical diagnosis of a gastrointestinal stromal tumor (GIST). A histological, immunohistochemical and molecular study was performed to exclude the misdiagnosis of GIST...
April 2016: Oncology Letters
https://www.readbyqxmd.com/read/27038995/resection-of-liver-metastases-in-patients-with-gastrointestinal-stromal-tumors-in-the-imatinib-era-a-nationwide-retrospective-study
#17
M F J Seesing, R Tielen, R van Hillegersberg, F van Coevorden, K P de Jong, I D Nagtegaal, C Verhoef, J H W de Wilt
INTRODUCTION: Liver metastases are common in patients with gastrointestinal stromal tumors (GIST). In the absence of randomized controlled clinical trials, the effectiveness of surgery as a treatment modality is unclear. This study identifies safety and outcome in a nationwide study of all patients who underwent resection of liver metastases from GIST. METHODS: Patients were included using the national registry of histo- and cytopathology (PALGA) of the Netherlands from 1999...
September 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26982239/a-successful-approach-to-overcome-imatinib-induced-skin-toxicity-in-a-gist-patient
#18
Ingrid M E Desar, Carla M L van Herpen, Nielka P van Erp, Suzanne E J Kaal, Peter C M van de Kerkhof, Winette T A van der Graaf
Since the introduction of tyrosine kinase inhibitors in gastrointestinal stromal tumor patients, the median survival of patients has increased from less than 1 to more than 5 years. The chronic use of a tyrosine kinase inhibitor has an impact on quality of life because of its toxicity. Adequate supportive therapy is therefore important. We describe a female patient with a metastatic gastrointestinal stromal tumor. During treatment with the c-KIT inhibitor imatinib, she developed severe therapy-limiting skin toxicity...
July 2016: Anti-cancer Drugs
https://www.readbyqxmd.com/read/26895210/bronchial-paraganglioma-with-sdhb-deficiency
#19
M R Ghigna, P Dorfmuller, A Crutu, E Fadel, V Thomas de Montpréville
Though most paragangliomas arise as sporadic tumors, the recent advantages in the genetic screening revealed that about 30 % of paragangliomas are linked to hereditary mutations, such as those involving SDH genes. A 22-year-old woman carrying a left main bronchus tumor underwent surgery in our institution. Her past medical history included a GIST without KIT or PDGFRA mutation. The histological examination revealed a nested proliferation of medium-sized cells expressing neuroendocrine markers (chromogranin A and synaptophysin)...
December 2016: Endocrine Pathology
https://www.readbyqxmd.com/read/26807239/computed-tomography-imaging-characteristics-of-synchronous-gastrointestinal-stromal-tumors-in-patients-with-gastric-cancer-and-correlation-with-clinicopathological-findings
#20
Zhenshan Shi, Qian Zhuang
This study was conducted to analyze the computed tomography (CT) imaging and clinicopathological characteristics of synchronous gastrointestinal stromal tumors (GISTs) in patients with gastric cancer. We retrospectively reviewed the CT images in 18 cases of immunohistochemically confirmed synchronous GISTs in patients with primary gastric cancer. Relevant histology and clinical data were also obtained. Multi-slice CT (MSCT) identified suspected synchronous GISTs in 26 patients, of which 18 were finally confirmed...
November 2015: Molecular and Clinical Oncology
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