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https://www.readbyqxmd.com/read/29139072/elimination-and-detoxification-of-2-4-d-by-umbelopsis-isabellina-with-the-involvement-of-cytochrome-p450
#1
Justyna Nykiel-Szymańska, Paulina Stolarek, Przemysław Bernat
The chemical 2,4-dichlorophenoxyacetic acid (2,4-D) is used in agriculture as a herbicide. Its intensive use has an adverse effect on the environment. This study involved examining the degradation of 2,4-D compound by the filamentous fungus Umbelopsis isabellina. After 5 days of incubation, 98% of the herbicide (added at 25 mg L(-1)) was found to be removed. The elimination of 2,4-D by U. isabellina was connected with the formation of 2,4-dichlorophenol (2,4-DCP), which resulted in a 60% decrease in the sample toxicity toward Artemia franciscana larvae...
November 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29122117/plate-versus-intramedullary-fixation-of-two-part-and-multifragmentary-displaced-midshaft-clavicle-fractures-a-long-term-analysis
#2
Gareth Chan, Zelimir Korac, Matija Miletic, Dinko Vidovic, Joideep Phadnis, Bore Bakota
INTRODUCTION: Surgical fixation of displaced midshaft clavicle fractures is predominantly achieved with intramedullary (IM) or plate fixation. Both techniques have potential pitfalls: plate fixation involves greater periosteal stripping and protuberance of the implant, whereas IM fixation may be associated with implant-related complications, such as migration or skin irritation, which may lead to further surgery for implant removal. The aim of this study was to compare these two methods in simple (Robinson 2b...
November 2017: Injury
https://www.readbyqxmd.com/read/29113322/artificial-neural-network-models-for-early-diagnosis-of-hepatocellular-carcinoma-using-serum-levels-of-%C3%AE-fetoprotein-%C3%AE-fetoprotein-l3-des-%C3%AE-carboxy-prothrombin-and-golgi-protein-73
#3
Bo Li, Boan Li, Tongsheng Guo, Zhiqiang Sun, Xiaohan Li, Xiaoxi Li, Lin Chen, Jing Zhao, Yuanli Mao
More than 70% of hepatocellular carcinoma (HCC) cases develop as a consequence of liver cirrhosis (LC). Here we have evaluated the diagnostic potential of four serum biomarkers, and developed models for HCC diagnosis and differentiation from LC patients. Serum levels of α-fetoprotein (AFP), AFP-L3, des-γ-carboxy prothrombin (DCP), and Golgi protein 73 (GP73) were analyzed in 114 advanced HCC patients, 81 early stage HCC patients, and 152 LC patients. Multilayer perceptron (MLP) and radial basis function (RBF) neural networks were used to construct the diagnostic models...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29112841/extraction-and-quantification-of-chlorophenolate-molecules-in-soils-spiked-with-2-4-dichlorophenol-and-2-4-5-trichlorophenol
#4
Diana Bello, Carmen Trasar-Cepeda
The compounds 2,4-dichlorophenol (2,4-DCP) and 2,4,5-trichlorophenol (2,4,5-TCP) are classified as priority pollutants, with potentially hazardous impacts on the environment. In soil, dissociation of the phenol group occurs, resulting in the simultaneous presence of neutral phenol and anionic phenolate. Although the toxicity of 2,4-DCP and 2,4,5-TCP to soil microbiota has been suggested to be mainly due to the phenolate anion, this hypothesis cannot be tested due to the lack of appropriate methods of extracting and quantifying the anionic form of these compounds (unlike the neutral form, which can be easily quantified)...
November 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29108396/evaluation-of-pseudophakic-cystoid-macular-edema-using-optical-coherence-tomography-angiography
#5
Rita Serra, Alexandre Sellam, Florence Coscas, Elsa Bruyère, André Sieiro, Gabriel J Coscas, Eric H Souied
PURPOSE: To compare the optical coherence tomography angiography (OCT-A) findings of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in eyes with pseudophakic cystoid macular edema (PCME) with those of fluorescein angiography (FA) and spectral-domain optical coherence tomography (SD-OCT) and to compare PCME vascular density values of the SCP and DCP with those of healthy eyes. METHODS: In this retrospective observational study, 13 eyes (12 patients) with PCME underwent comprehensive ophthalmologic examinations including visual acuity, FA, SD-OCT, and OCT-A...
November 1, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29108069/dietary-sources-of-phosphorus-affect-postileal-phosphorus-digestion-in-growing-pigs
#6
J B Liu, X Y Shen, H X Zhai, L Chen, H F Zhang
The present study was conducted to investigate the postileal P digestion response of growing pigs to dietary P concentrations and sources. Twenty-four pigs (57.3 ± 1.9 kg initial BW) fitted with T-cannulas at the distal ileum were assigned to a duplicated 12 × 4 incomplete Latin square design with 12 diets and 4 periods. The 12 experimental diets consisted of 9 cornstarch-based diets using soybean meal (SBM), corn distiller's dried grains with solubles (DDGS), and canola meal (CM) as assay ingredients at 3 levels and 3 corn-SBM-based practical diets with 3 levels of dicalcium phosphate (DCP)...
October 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/29103961/high-resolution-imaging-in-male-germ-cell-associated-kinase-mak-related-retinal-degeneration
#7
Young Ju Lew, Nicholas Rinella, Jia Qin, Joanna Chiang, Anthony T Moore, Travis C Porco, Austin Roorda, Jacque L Duncan
PURPOSE: To describe the characteristics of MAK-related retinal degeneration using optical coherence tomography angiography (OCTA) and adaptive optics scanning laser ophthalmoscopy (AOSLO). DESIGN: Cross-sectional study. METHODS: Six patients with rod-cone degeneration and disease-causing mutations in MAK were evaluated with visual acuity, spectral domain OCT, confocal AOSLO and OCTA. Foveal avascular zone (FAZ) area, vessel densities and perfusion densities of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in the central macula in all 6 patients were compared with 5 normal subjects...
November 2, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29102446/-impact-of-disabling-chronic-pain-results-of-a-cross-sectional-population-study-with-face-to-face-interview
#8
Andrés Cabrera-Leon, Miguel Ángel Cantero-Braojos
OBJECTIVE: To assess the impact of disabling chronic pain (DCP) on quality of life, work, consumption of medication and usage of health services. DESIGN: Cross-sectional population study with face-to-face interview. SETTING: Andalusian Health Survey (2011 edition). PARTICIPANTS: 6,507 people over the age of 16 (p=q=0.5; confidence level=95%; sampling error=1.49, design effect=1.52). INTERVENTIONS: Not applicable...
November 1, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/29100130/heterologous-expression-and-characterization-of-three-laccases-obtained-from-pleurotus-ostreatus-haucc-162-for-removal-of-environmental-pollutants
#9
Rui Zhuo, Hongbo Yu, Peng Yuan, Jiahui Fan, Longjiao Chen, Yuan Li, Fuying Ma, Xiaoyu Zhang
Chlorophenols (CPs), nitrophenols (NPs), and sulfonamide antibiotics (SAs) are three types of environmental pollutants that are of great concern because of their prevalence and toxicity. In this study, three laccase isoenzymes obtained from Pleurotus ostreatus HAUCC 162 were heterologously expressed and characterized with respect to their ability to degrade CPs, NPs, and, SAs. The three recombinant laccases can efficiently degrade the three types of considered pollutants using a laccase-mediator system (LMS)...
October 28, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29098905/cellular-accumulation-and-antioxidant-activity-of-acetoxymethoxycarbonyl-pyrrolidine-nitroxides
#10
Sergey I Dikalov, Anna E Dikalova, Denis A Morozov, Igor A Kirilyuk
Nitroxides are widely used in biology as antioxidants, spin labels, functional spin probes for pH, oxygen and thiol levels, and tissue redox status imaging using electron paramagnetic resonance (EPR); however, biological applications of nitroxides is hindered by fast bioreduction to EPR-silent hydroxylamines and rapid clearance. In this work, we have studied pyrrolidine nitroxides with acetoxymethoxycarbonyl groups which can undergo hydrolysis by cellular esterases to hydrophilic carboxylate derivatives resistant to bioreduction...
November 3, 2017: Free Radical Research
https://www.readbyqxmd.com/read/29089353/macular-capillary-plexuses-after-epiretinal-membrane-surgery-an-optical-coherence-tomography-angiography-study
#11
Yoon Jeon Kim, Seungmo Kim, Joo Yong Lee, June-Gone Kim, Young Hee Yoon
AIMS: To investigate macular vascular integrity using optical coherence tomography angiography (OCTA) in patients undergoing vitrectomy for idiopathic epiretinal membrane (ERM) removal and to determine its association with structural and visual outcomes. METHODS: Forty-three patients with unilateral ERM who were followed for ≥6 months after surgery were included. Ophthalmological evaluations included best-corrected visual acuity (BCVA) and spectral-domain OCT (SD-OCT) before surgery and 6 months after surgery...
October 31, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29075766/quantitative-analysis-of-three-distinct-retinal-capillary-plexuses-in-healthy-eyes-using-optical-coherence-tomography-angiography
#12
Sean T Garrity, Nicholas A Iafe, Nopasak Phasukkijwatana, Xuejing Chen, David Sarraf
Purpose: To identify and quantify the three distinct retinal capillary plexuses and the foveal avascular zone (FAZ) in healthy subjects according to age using optical coherence tomography angiography (OCTA) with novel projection artifact removal (PAR) software and improved segmentation. Methods: All eyes in this cross-sectional study underwent OCTA imaging using RTVue XR Avanti with novel PAR AngioVue software. OCTA scans were analyzed and the three main parafoveal retinal capillary plexuses were segmented and vessel density and FAZ area were calculated...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29074986/self-cleaning-liner-for-halogenated-hydrocarbon-control-in-landfill-leachate
#13
Shichong He, Lizhong Zhu
Sorptive landfill liners can prevent the migration of the leachate pollutants. However, their sorption ability will decrease over time. A method should be developed to maintain the sorption ability of landfill liners. In this study, we combined cetyltrimethylammonium bromide-bentonite (CTMAB-bentonite) and zero-valent iron (ZVI) to develop a self-cleaning liner that can retain its sorption ability for a long period. Batch experiments and calculation simulations were employed to analyse the sorption ability of this liner material and the ecological risk of halogenated hydrocarbons...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29068306/direct-primary-care-is-about-to-take-off-or-maybe-not
#14
Charlotte Huff
Direct primary care (DPC) occupies only a small niche in the health care payment system. But proponents say that federal legislation that would allow people to pay the monthly fee with health savings account dollars would help DCP take off.
September 2017: Managed Care
https://www.readbyqxmd.com/read/29062819/conventional-plate-and-screws-in-medial-opening-wedge-high-tibial-osteotomy-are-they-sufficiently-stable-a-retrospective-study
#15
Rodrigo Salim, Fabricio Fogagnolo, Mauricio Martins Perina, Ugo Messas Rubio, Mauricio Kfuri Junior
OBJECTIVE: Opening-wedge osteotomy of the proximal tibia is a widely performed procedure for treating medial gonarthrosis in active patients and in the presence of varus malalignment of the lower limb. The fixation method is controversial, and the use of conventional implants has been abandoned in favor of implants with more modern locking screws. The aim of the present clinical study was to assess the maintenance of the correction achieved in cases wherein fixation was performed using conventional implants...
September 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29059262/quantifying-microvascular-abnormalities-with-increasing-severity-of-diabetic-retinopathy-using-optical-coherence-tomography-angiography
#16
Peter L Nesper, Philipp K Roberts, Alex C Onishi, Haitao Chai, Lei Liu, Lee M Jampol, Amani A Fawzi
Purpose: We quantified retinal and choriocapillaris microvascular changes in healthy control eyes and different stages of diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA). Methods: This retrospective cross-sectional study included 137 eyes of 86 patients with different stages of DR and 44 eyes of 26 healthy age-matched controls. Participants were imaged with a commercial OCTA device (RTVue-XR Avanti). We analyzed the superficial (SCP) and deep (DCP) retinal capillary plexus, the full retina, and choriocapillaris for the following OCTA parameters: foveal avascular zone, vessel density, percent area of nonperfusion (PAN), and adjusted flow index (AFI)...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29050185/-optical-coherence-tomography-angiography-of-acute-vogt-koyanagi-harada-disease
#17
S S Jia, C Zhao, D Gong, Z Chen, M F Zhang
Objective: To measure vascular density in retinal and choroidal capillary layers by optical coherence tomography angiography (OCTA) and to explore their potential clinical values in Vogt-Koyanagi-Harada disease (VKH). Methods: This is a cross-sectional case-control study. Twenty-one acute VKH cases presented to Peking Union Medical College Hospital between April 2015 and July 2015 and 49 healthy controls were enrolled in this study. OCTA was performed with a split-spectrum amplitude-decorrelation angiography-optical coherence tomography (SSADA-OCT) system borrowed from Optovue Inc...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29035607/accuracy-of-w-recovery-kinetics-in-high-performance-cyclists-modelling-intermittent-work-capacity
#18
Jason C Bartram, Dominic Thewlis, David T Martin, Kevin I Norton
PURPOSE: With knowledge of an individual's critical power (CP) and W' the SKIBA 2 model provides a framework with which to track W' balance during intermittent high intensity work bouts. There are fears the time constant controlling the recovery rate of W' (τW') may require refinement to enable effective use in an elite population. METHODS: Four elite endurance cyclists completed an array of intermittent exercise protocols to volitional exhaustion. Each protocol lasted approximately 3...
October 16, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28990799/the-effect-of-dietary-energy-protein-ratio-protein-quality-and-food-allocation-on-the-efficiency-of-utilisation-of-protein-by-broiler-chickens
#19
R M Gous, A S Faulkner, H K Swatson
Various theories have been proposed to explain the reduced performance of broilers when given feeds excessively high in protein, but a satisfactory solution to this problem had, up to now, not been found. Three experiments were conducted to test the hypothesis that the efficiency of utilisation of protein (ep) is a linear-plateau function of the ratio between the feed apparent metabolisable energy and digestible crude protein contents (AMEn: DCP), and that dietary protein quality, feed allocation and sex do not influence this relationship...
October 9, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28988557/effects-of-dietary-inclusion-of-citrus-pulp-and-rockrose-soft-stems-and-leaves-on-lamb-meat-quality-and-fatty-acid-composition
#20
A Francisco, S P Alves, P V Portugal, M T Dentinho, E Jerónimo, S Sengo, J Almeida, M C Bressan, V M R Pires, C M Alfaia, J A M Prates, R J B Bessa, J Santos-Silva
Meat from lambs finished with high-starch diets often contains low concentration of vaccenic (t11-18:1) and rumenic (c9,t11-18:2) acids and high concentration of t10-18:1. We hypothesized that replacing cereals by dehydrated citrus pulp (DCP) and the inclusion of tanniferous feed sources in oil supplemented diets might reduce the accumulation of t10-18:1 and increase the t11-18:1 and c9,t11-18:2 in lamb meat, without affecting the productive performance. In total, 32 lambs were assigned to four diets which combine two factors: basal diet (BD) (cereals v...
October 9, 2017: Animal: An International Journal of Animal Bioscience
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