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Yuan-Chao Cai, Chen Li, Qin-Hua Song
Nerve agents are highly toxic organophosphorus compounds, and their possible use in terrorist attacks has led to increasing interest in the development of reliable and accurate methods to detect these lethal chemicals. In this paper, we have prepared six 6-aminoquinolines with various N-substituents as chemosensors for a nerve-agent mimic diethylchlorophosphate (DCP). The chemosensors with the nucleophilic pyridine-N atom as the active site detect DCP via a catalytic hydrolysis approach to form the protonated sensor...
June 23, 2017: ACS Sensors
Masakazu Katsumata, Yuko Ikushima, Keith Bennett, Yukiko Sato, Ayano Takeuchi, Norihisa Tatarazako, Tomoyuki Hakamata
Algal growth inhibition tests are generally used to determine the toxic effects of chemical substances on algae growth. In this report, we describe a rapid and simple test procedure using delayed fluorescence (DF) to determine chemical toxicities more rapidly than the conventional 72h or 96h growth inhibition tests. We assess the suitability of DF to serve as an alternative endpoint for biomass production and determine the variability by an interlaboratory ring study using a typical reference toxicant 3,5-dichlorophenol (DCP)...
July 3, 2017: Science of the Total Environment
Sumreen Asim, Yunqing Zhu, Aisha Batool, Reshalaiti Hailili, Jianmin Luo, Yuanhao Wang, Chuanyi Wang
2, 4-dichlorophenol (2, 4-DCP) is considered to be a highly toxic, mutagenic, and possibly carcinogenic pollutant. This study is focused on the electrochemical oxidation of 2, 4-DCP on nanostructured 3D-porous Ti/Sb-SnO2-Gr anodes, with the aim of presenting a comprehensive elucidation of mineralization process through the investigation of influential kinetics, the reactivity of hydroxyl radical's and analysis of intermediates. High efficiency was achieved at pH of 3 using Na2SO4 electrolytes at a current density of 30 mA cm(-2)...
June 30, 2017: Chemosphere
Hana L Takusagawa, Liang Liu, Kelly N Ma, Yali Jia, Simon S Gao, Miao Zhang, Beth Edmunds, Mansi Parikh, Shandiz Tehrani, John C Morrison, David Huang
PURPOSE: To detect macular perfusion defects in glaucoma using projection-resolved optical coherence tomography (OCT) angiography. DESIGN: Prospective observation study. PARTICIPANTS: A total of 30 perimetric glaucoma and 30 age-matched normal participants were included. METHODS: One eye of each participant was imaged using 6 × 6-mm macular OCT angiography (OCTA) scan pattern by 70-kHz 840-nm spectral-domain OCT. Flow signal was calculated by the split-spectrum amplitude-decorrelation angiography algorithm...
July 1, 2017: Ophthalmology
Syed Samim Ali, Ankita Gangopadhyay, Kalipada Maiti, Sanchita Mondal, Ajoy Kumar Pramanik, Uday Narayan Guria, Md Raihan Uddin, Sukhendu Mandal, Debasish Mandal, Ajit Kumar Mahapatra
A new cyanine dye (CYD) based on hybrid hydroxynaphthalene-hemicyanine has been synthesized and characterized. The chromogenic and ratiometric fluorogenic probe (CYD) enables a fast and highly sensitive response to an OP nerve agent mimic diethyl chlorophosphate (DCP) through tandem phosphorylation and intramolecular cyclization reaction within 1 min and with the detection limit as low as 18.86 nM. To our knowledge this is the first report of a hydroxyl assisted bathochromic shift in a selective chemodosimeter for DCP exhibiting a ratiometric response...
July 19, 2017: Organic & Biomolecular Chemistry
Muhammad Oboirien, Stephen Patrick Agbo, Lukman Olalekan Ajiboye
BACKGROUND: The use of conventional dynamic compression plates (DCPs) in osteoporotic bones is associated with higher chances of implant failure. The advent and use of locking combi-plates have ensured a stable construct during osteosynthesis of fractures in osteoporotic bones. OBJECTIVES: The study aims to assess the outcome of use of locking combi-plates in the management of fractures in osteoporotic bones in our environment. MATERIALS AND METHODS: Cases of patients with nonunion and localized osteoporosis from January 2014 to December 2014 that were managed with locked combi-plates were reviewed...
July 2017: Annals of African Medicine
Sumana Bhar, Rajakumar Ananthakrishnan
The work focuses on room-temperature photocatalytic degradation of phenolic compounds by Ru(ii)-complex immobilized mesoporous silica SBA-15 under visible light in an aqueous medium. The immobilization of [Ru(bpy)3]Cl2 complex on an SBA-15 surface is carried out, and the as-synthesized hybrid is characterized by X-ray Diffraction (XRD), Fourier Transformation IR Spectroscopy (FTIR), Diffuse Reflectance Spectroscopy (DRS), Brunauer-Emmett-Teller analysis (BET), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray analysis (EDX) and X-ray Photoelectron Spectroscopy (XPS)...
June 29, 2017: Photochemical & Photobiological Sciences
Issei Saeki, Takahiro Yamasaki, Masaki Maeda, Takuro Hisanaga, Takuya Iwamoto, Toshihiko Matsumoto, Isao Hidaka, Tsuyoshi Ishikawa, Taro Takami, Isao Sakaida
AIM: Sorafenib is the recommended standard of care for advanced hepatocellular carcinoma (HCC) patients. However, hepatic arterial infusion chemotherapy (HAIC) is a treatment option in Asia. We recently developed the 'assessment for continuous treatment with HAIC' (ACTH) score to guide decision-making for continuous HAIC treatment. The purpose of this study was to validate the utility of the ACTH score in a dedicated cohort. METHODS: One-hundred and thirty-one advanced HCC patients were enrolled in this study (90 in the training group and 41 in the validation group)...
June 28, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Paul S Whiting, Phillip M Mitchell, Aaron M Perdue, Arnold J Silverberg, Sarah E Greenberg, Rachel V Thakore, Vasanth Sathiyakumar, Hassan R Mir, William T Obremskey, Manish K Sethi
The purpose of this study was to evaluate damage control plating (DCP) as an alternative to external fixation (EF) in the provisional stabilization of open tibial shaft fractures. Through retrospective analysis, the study found 445 patients who underwent operative fixation for tibial shaft fractures from 2008 to 2012. Twenty patients received DCP or EF before intramedullary nailing with a minimum follow-up of 3 months. Charts and radiographs were reviewed for postoperative complications. Hospital charges were reviewed for implant costs...
2017: Journal of Surgical Orthopaedic Advances
Charlotte J Mable, Matthew J Derry, Kate L Thompson, Lee A Fielding, Oleksandr O Mykhaylyk, Steven P Armes
Silica-loaded poly(glycerol monomethacrylate)-poly(2-hydroxypropyl methacrylate) diblock copolymer vesicles are prepared in the form of concentrated aqueous dispersions via polymerization-induced self-assembly (PISA). As the concentration of silica nanoparticles present during the PISA synthesis is increased up to 35% w/w, higher degrees of encapsulation of this component within the vesicles can be achieved. After centrifugal purification to remove excess non-encapsulated silica nanoparticles, SAXS, DCP, and TGA analysis indicates encapsulation of up to hundreds of silica nanoparticles per vesicle...
June 13, 2017: Macromolecules
Thanapong Somkijrungroj, Sritatath Vongkulsiri, Wijak Kongwattananon, Peranut Chotcomwongse, Sasivarin Luangpitakchumpol, Korrawan Jaisuekul
OBJECTIVE: To evaluate retinal vascular structural change in ocular Behcet's using optical coherence tomography angiography (OCTA) and fluorescein angiography (FA). METHODS: An analytic cross-sectional study of 37 eyes of 21 Behcet's uveitic patients was performed. Foveal retinal thickness (FRT), perifoveal hypoperfusion areas in superficial capillary plexus (SCP), and deep capillary plexus (DCP) were measured with swept-source optical coherence tomography and OCTA...
2017: Journal of Ophthalmology
Gustavo Facchini, Samara Eberlin, Stefano Piatto Clerici, Ana Lucia Tabarini Alves Pinheiro, Adilson Costa
BACKGROUND: Unwanted side effects such as dryness, hypersensitivity, and cutaneous photosensitivity are challenge for adherence and therapeutical success for patients using treatments for inflammatory and allergic skin response. AIMS: In this study, we compared the effects of two dermatological formulations, which are used in inflammatory and/or allergic skin conditions: dexchlorpheniramine maleate (DCP; 10 mg/g) and promethazine (PTZ; 20 mg/g). METHODS: We evaluated both formulations for phototoxicity potential, skin irritation, anti-inflammatory and antihistaminic abilities, and skin barrier repair in vitro and ex vivo using the standard OECD test guideline n° 432, the ECVAM protocol n° 78, and cultured skin explants from a healthy patient...
June 7, 2017: Journal of Cosmetic Dermatology
Dengbin Yu, Yang-Chun Yong, Changyu Liu, Youxing Fang, Lu Bai, Shaojun Dong
A novel mediator-free method based on genetically modified bacteria was developed for detecting water toxicity, where genetically modified Pseudomonas aeruginosa (GM P. aeruginosa) was selected as the biosensor strain and pyocyanin (PYO) produced by this strain was used as the indicator. The toxicity response of GM P. aeruginosa to 3, 5-dichlorophenol (3, 5-DCP) was measured electrochemically and spectroscopically, and the half maximal inhibitory concentration (IC50) of 3, 5-DCP was determined to be 15.1 mg/L...
May 29, 2017: Chemosphere
Peter Smittenaar, Jennifer C Erhart-Hledik, Rose Kinsella, Simon Hunter, Gabriel Mecklenburg, Daniel Perez
BACKGROUND: Chronic knee pain (CKP) affects a large number of adults, many of whom do not receive best-practice care and are at high risk for unnecessary surgery. OBJECTIVE: The aim of this study was to investigate the effect of the Hinge Health 12-week digital care program (DCP) for CKP on knee pain and function, with secondary outcomes of surgery interest and satisfaction, at 12 weeks and 6 months after starting the program. METHODS: Individuals with CKP were recruited onto the 12-week program, comprising sensor-guided physical exercises, weekly education, activity tracking, and psychosocial support such as personal coaching and cognitive behavioral therapy (CBT)...
April 5, 2017: JMIR Rehabil Assist Technol
Daniel Seknazi, Florence Coscas, Alexandre Sellam, Fabien Rouimi, Gabriel Coscas, Eric H Souied, Agnès Glacet-Bernard
PURPOSE: To study correlations in patients with retinal vein occlusion between the automatically quantified macular vascular densities in the superficial and deep capillary plexus (DCP) obtained using optical coherence tomography angiography (OCTA) and the data from conventional examination, particularly visual acuity and peripheral retinal nonperfusion assessed using fluorescein angiography (FA). METHODS: Retrospective, observational study of patients with retinal vein occlusion who underwent a comprehensive ophthalmic examination including FA and OCTA using the AngioVue OCTA system version 2015...
May 31, 2017: Retina
V Anandan, W Afthab Jameela, R Sowmiya, M Mani Surya Kumar, P Lavanya
INTRODUCTION: Pemphigus, an autoimmune disease, was fatal before the era of corticosteroids. With the advent of steroids, mortality decreased but morbidity was present due to the side effects of high dose steroids. Newer drugs targeted at the molecular level are said to have fewer side effects and improved effectiveness. AIM: The aim of our study was to assess the effectiveness of one such drug, Rituximab, a biological, in treating pemphigus vulgaris and to identify common adverse events...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
Quirino Lai, Samuele Iesari, Giovanni Battista Levi Sandri, Jan Lerut
BACKGROUND: The use of des-gamma-carboxy prothrombin (DCP) as a predictor of the risk of recurrence of hepatocellular cancer (HCC) after liver transplant (LT) has recently gained interest, especially in view of the recent extension of the eligibility criteria of these patients for LT. The aim of the present study is to look into this important matter based on a systematic review and meta-analysis. METHODS: A systematic literature review about the role of DCP in the specific setting of LT for HCC has been conducted...
May 26, 2017: International Journal of Biological Markers
Yu Toyoda, Tappei Takada, Hiroshi Suzuki
Recently, epidemiological studies revealed a positive relationship between an outbreak of occupational cholangiocarcinoma and exposure to organic solvents containing 1,2-dichloropropane (1,2-DCP). In 1,2-DCP-administered animal models, we previously found biliary excretion of potentially oncogenic metabolites consisting of glutathione- (GSH-) conjugated forms of 1,2-DCP (GS-DCPs); however, the GS-DCP production pathway remains unknown. To enhance the understanding of 1,2-DCP-related risks to human health, we examined the reactivity of GSH with 1,2-DCP in vitro and compared it to that with dichloromethane (DCM), the other putative substance responsible for occupational cholangiocarcinoma...
2017: Oxidative Medicine and Cellular Longevity
Qi-Fan Qin, Jie Weng, Gan-Xin Xu, Chun-Ming Chen, Chang-Ku Jia
OBJECTIVE: To evaluate the detection accuracy of the biomarkers dickkopf-1, DCP and AFP as a serum biomarker panel by comparing the sensitivity of the panel with those of the individual biomarkers. METHODS: The study was composed of three groups, one with HCC patients, one with non-HCC liver diseases and one with healthy controls. Serum AFP was measured using a chemiluminescence assay and serum dickkopf-1 and DCP were measured with ELISA. The sensitivity and specificity of the biomarkers were analyzed as single parameters and as a serum panel...
April 2017: Asian Pacific Journal of Tropical Medicine
Guangming Jiang, Mengna Lan, Zhiyong Zhang, Xiaoshu Lv, Zimo Lou, Xinhua Xu, Fan Dong, Sen Zhang
Clarifying hydrogen evolution and identifying the active hydrogen species are crucial to the understanding of the electrocatalytic hydrodechlorination (EHDC) mechanism. Here, monodisperse palladium nanoparticles (Pd NPs) are used as a model catalyst to demonstrate the potential-dependent evolutions of three hydrogen species, including adsorbed atomic hydrogen (H*ads), absorbed atomic hydrogen (H*abs), and molecular hydrogen (H2) on Pd NPs, and then their effect on EHDC of 2,4-dichlorophenol (2,4-DCP). Our results show that H*ads, H*abs, and H2 all emerge at -0...
June 13, 2017: Environmental Science & Technology
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