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Kailun Yang, Jia Li, Yang Peng, Jun Lin
In this study, we have fabricated crystalline metallic Pt nanoparticles-loaded α-Bi2O3 microrods (Pt/Bi2O3) using a precipitation method, followed by an impregnation-reduction deposition route. The Pt/Bi2O3 catalysts have much higher photocatalytic activities than that of the pure Bi2O3 for the degradation of RhB and 2,4-DCP under visible light irradiation. The photogenerated charge separation, transfer, and capture in the photocatalysis of Pt/Bi2O3 were investigated in detail according to the various characterizations and analyses of the photogenerated active species and H2O2...
November 30, 2016: Physical Chemistry Chemical Physics: PCCP
Tomohiro Iguchi, Motoyuki Yamagata, Takashi Sonoda, Kimihiko Yanagita, Tetsuhiro Fukahori, Eiji Tsujita, Shinichi Aishima, Yoshinao Oda, Yoshihiko Maehara
Malignant transformation of hepatocellular adenoma (HA) is relatively rare and has been reported to be associated with dysregulation of the β-catenin pathway. The presence of bone marrow metaplasia in HA is an uncommon histological characteristic. The current report presents the case of a 46-year-old woman with glycogen storage disease type I (von Gierke's disease) who underwent resection of hepatocellular carcinoma (HCC) arising in a HA with associated bone marrow metaplasia producing three series of hematopoietic cells...
November 2016: Molecular and Clinical Oncology
Caelin Cubeñas-Potts, M Jordan Rowley, Xiaowen Lyu, Ge Li, Elissa P Lei, Victor G Corces
Eukaryotic gene expression is regulated by enhancer-promoter interactions but the molecular mechanisms that govern specificity have remained elusive. Genome-wide studies utilizing STARR-seq identified two enhancer classes in Drosophila that interact with different core promoters: housekeeping enhancers (hkCP) and developmental enhancers (dCP). We hypothesized that the two enhancer classes are occupied by distinct architectural proteins, affecting their enhancer-promoter contacts. By evaluating ChIP-seq occupancy of architectural proteins, typical enhancer-associated proteins, and histone modifications, we determine that both enhancer classes are enriched for RNA Polymerase II, CBP, and architectural proteins but there are also distinctions...
November 28, 2016: Nucleic Acids Research
Lisa Toto, Enrico Borrelli, Rodolfo Mastropasqua, Alfonso Senatore, Luca Di Antonio, Marta Di Nicola, Paolo Carpineto, Leonardo Mastropasqua
Purpose: To investigate correlations among macular ganglion cell complex (GCC) layer thickness, macular capillary density, and macular function in patients affected by retinitis pigmentosa (RP). Methods: Fourteen patients (28 eyes) with previous diagnosis of RP were enrolled. The diagnosis of these conditions was made based on both clinical features and electrophysiological examination. All patients underwent a complete ophthalmologic examination, including optical coherence tomography angiography (OCTA) and multifocal electroretinogram (mfERG)...
November 1, 2016: Investigative Ophthalmology & Visual Science
Tadashi Hirata, Young-Man Cho, Takeshi Toyoda, Jun-Ichi Akagi, Isamu Suzuki, Akiyoshi Nishikawa, Kumiko Ogawa
1,2-Dichloropropane (1,2-DCP) and dichloromethane (DCM) are possible causative agents associated with the development of cholangiocarcinoma in employees working in printing plant in Osaka, Japan. However, few reports have demonstrated an association between these agents and cholangiocarcinoma in rodent carcinogenicity studies. Moreover, the combined effects of these compounds have not been fully elucidated. In the present study, we evaluated the in vivo mutagenicity of 1,2-DCP and DCM, alone or combined, in the livers of gpt delta rats...
November 28, 2016: Journal of Applied Toxicology: JAT
Zichao Xue, Haitao Xu, Haoliang Ding, Hui Qin, Zhiquan An
Minimally invasive plate osteosynthesis (MIPO) has been widely accepted because of its satisfactory clinical outcomes. However, the implant construct that works best for MIPO remains controversial. Different plate designs result in different influence mechanisms to blood flow. In this study, we created ulnar fractures in 42 beagle dogs and fixed the fractures using MIPO. The dogs were randomly divided into two groups and were fixed with a limited contact dynamic compression plate (LC-DCP) or a locking compression plate (LCP)...
November 25, 2016: Scientific Reports
Jianxia Sun, Wei Xu, Cuijuan Zhu, Yunfeng Hu, Xinwei Jiang, Shiyi Ou, Zhijian Su, Yadong Huang, Rui Jiao, Weibin Bai
1,3-Dichloro-2-propanol (1,3-DCP) is a food processing contaminant and has been shown to perturb male reproductive function. Cyanidin-3-O-glucoside (C3G), an anthocyanin antioxidant, is reported to have protective effects on many organs. However, it remains unclear whether C3G protects against chemical-induced reproductive toxicity. The present study was therefore to investigate the intervention of C3G on 1,3-DCP-induced reproductive toxicity in R2C Leydig cells. Results demonstrated that C3G inhibited the 1,3-DCP-induced cytotoxicity and cell shape damage with the effective doses being ranging from 10 to 40 μmol/L...
2016: Frontiers in Pharmacology
Yusuke Kawamura, Kenji Ikeda, Shunichiro Fujiyama, Tetsuya Hosaka, Masahiro Kobayashi, Satoshi Saitoh, Hitomi Sezaki, Norio Akuta, Fumitaka Suzuki, Yoshiyuki Suzuki, Yasuji Arase, Hiromitsu Kumada
OBJECTIVE: The aim of this study was to clarify the usefulness of a no-touch pincer ablation procedure that uses bipolar electrodes to prevent intra-subsegmental tumor recurrence after radiofrequency ablation (RFA) for patients with hepatocellular carcinoma (HCC). METHODS: We studied 303 consecutive patients with HCC (single nodule and tumor diameter of ≤30 mm) who received RFA between January 2005 and April 2015; 268 patients received touch ablation using a monopolar or bipolar RFA device, and 35 received no-touch ablation using a bipolar RFA device...
November 15, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Jonathan Guzmán-Guevara, Gerardo López-Cázares, Rodolfo Gregorio Barragán-Hervella, José Saúl Alejandro Villegas-Rosas, Iván Alvarado-Ortega, Álvaro José Montiel-Jarquín
BACKGROUND: Humeral midshaft fractures should be surgically managed, so the knowledge of functionality, bone healing and pain of these treatments is required to obtain the expected results. The aim of this paper is to compare the results of patients with humeral midshaft fracture operated with intramedullary nails UHN vs. DCP plate. METHODS: Comparative study, conducted during the period of June 2014 to June 2015, in patients with humeral midshaft fracture, incidents, operated with intramedullary nails UHN vs...
2016: Revista Médica del Instituto Mexicano del Seguro Social
Jianbo Fu, Xiaoning Zhang, Peng Chen, Yingmei Zhang
2,4-Dichlorophenol (2,4-DCP) is an environmental pollutant exhibiting a wide spectrum of toxic effects. We investigated the toxic effects and potential mechanisms underlying 2,4-DCP-induced hepatotoxicity. In vitro, 2,4-DCP caused hepatotoxicity manifested by a decrease in cell viability and inhibition of colony formation. Bip and CHOP expression was up-regulated at the mRNA and protein levels. Moreover, 2,4-DCP induced eIF2α phosphorylation and Xbp1 mRNA splicing, indicating that endoplasmic reticulum (ER) stress was activated after exposure of HL7702 cells to 2,4-DCP for 12 hr...
2016: Journal of Toxicological Sciences
Pradeep Venkatesh, Akshay Tayade, Varun Gogia, Shikha Gupta, Bhavin M Shah, Rajpal Vohra
PURPOSE: To compare the efficacy of pulse cyclophosphamide with pulse dexamethasone in acute macular serpiginous choroiditis (SC). METHODS: A total of 30 patients with macular SC were prospectively randomized into three treatment groups: group D (pulse dexamethasone); group C (pulse cyclophosphamide); and combination (pulse group DCP) administered for 3 days. Macular SC was defined as any active lesion involving/threatening macula. RESULTS: A total of 30 patients were enrolled, with 10 patients in each group...
November 16, 2016: Ocular Immunology and Inflammation
Ju-Hyun Shin, Sang-Hyun Min
Caspases, a family of cysteine proteases, cleave substrates and play significant roles in apoptosis, autophagy, and development. Recently, our group identified 72 genes that interact with Death Caspase-1 (DCP-1) proteins in Drosophila by genetic screening of 15,000 EP lines. However, the cellular functions and molecular mechanisms of the screened genes, such as their involvement in apoptosis and autophagy, are poorly understood in mammalian cells. In order to study the functional characterizations of the genes in human cells, we investigated 16 full-length human genes in mammalian expression vectors and tested their effects on apoptosis and autophagy in human cell lines...
November 2016: Korean Journal of Physiology & Pharmacology
Masako Shomura, Tatehiro Kagawa, Haruka Okabe, Koichi Shiraishi, Shunji Hirose, Yoshitaka Arase, Kota Tsuruya, Sachiko Takahira, Tetsuya Mine
BACKGROUND: This study aimed to identify the health-related quality of life (HRQOL) domains associated with prognosis by assessing longitudinal alterations in HRQOL in patients with advanced hepatocellular carcinoma receiving sorafenib. METHODS: We prospectively assessed HRQOL by administering the SF-36 questionnaire 3-monthly to consecutive patients with advanced hepatocellular carcinoma receiving sorafenib. We evaluated the impact of HRQOL on their overall survival and duration of treatment with sorafenib using Cox's proportional hazards model...
November 11, 2016: BMC Cancer
Junichi Togashi, Nobuhisa Akamastu, Norihiro Kokudo
BACKGROUND: Living donor liver transplantation (LDLT) is an established treatment not only for those with end-stage liver disease but for those with hepatocellular carcinoma (HCC) developing in cirrhotic liver. The aim of this study was to present a single-center experience of LDLT for HCC at the University of Tokyo Hospital, Japan. METHODS: Among 573 liver transplant recipients from January 1996 until the end of 2015, 139 patients have been indicated LDLT for the treatment of HCC, and were the subjects of the present study...
October 2016: Hepatobiliary Surgery and Nutrition
Naoko Kamo, Toshimi Kaido, Shintaro Yagi, Hideaki Okajima, Shinji Uemoto
BACKGROUND: We treat small hepatocellular carcinoma (HCC) ≤3 cm in diameter by liver transplantation (LT) considering liver reserve and HCC localization, and when other treatment would be ineffective. However, the outcomes of LT and the clinicopathological features of small HCC ≤3 cm in diameter are not clear. We analyzed the outcomes of LT for small HCC ≤3 cm in diameter. METHODS: Between February 1999 and August 2015, 223 patients underwent LT for HCC at Kyoto University Hospital...
October 2016: Hepatobiliary Surgery and Nutrition
Na Wu, Dong Wei, Yongfang Zhang, Weiying Xu, Tao Yan, Bin Du, Qin Wei
The objective of this study was to compare the release of soluble microbial products (SMP) from activated sludge (AS) and aerobic granular sludge (AGS) in the absence and presence of 2,4-dichlorophenol (2,4-DCP). Data implied that NH4(+)-N removal efficiencies remarkably decreased to 53.8% and 36.4% after the addition of 2,4-DCP, respectively. Three-dimensional excitation-emission matrix (3D-EEM) implied that three major components (tryptophan protein-like, humic-like and fulvic-like substances) were identified in SMP without the addition of 2,4-DCP...
November 3, 2016: Bioprocess and Biosystems Engineering
Norifumi Harimoto, Tomoharu Yoshizumi, Tomonari Shimagaki, Akihisa Nagatsu, Takashi Motomura, Noboru Harada, Hirohisa Okabe, Shinji Itoh, Toru Ikegami, Hideaki Uchiyama, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: Inflammation-besed prognostic score including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), modified Glasgow prognostic score (mGPS) and prognostic nutritional index (PNI) have prognostic value in various malignancies. PATIENTS AND METHODS: We retrospectively investigated their prognostic value in 213 patients with living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). Disease-free survival (DFS) following LDLT was calculated; NLR, PLR, PNI and mGPS values in patients with and without recurrence were compared...
October 2016: Anticancer Research
Nicholas A Iafe, Nopasak Phasukkijwatana, Xuejing Chen, David Sarraf
Purpose: The purpose of this study was to quantify retinal capillary density and the foveal avascular zone (FAZ) area in normal subjects according to age, using optical coherence tomography angiography (OCTA). Methods: All eyes in this cross-sectional study underwent OCTA using RTVue XR Avanti with AngioVue. OCTA scans were analyzed and processed, and vessel density and FAZ dimensions were calculated. Results: A total of 113 normal eyes from 70 subjects were included (30 males, 40 females; mean 48 ± 20 years of age)...
October 1, 2016: Investigative Ophthalmology & Visual Science
Qimei Wu, Xiaoyu Yang, Lei Zhang, Yu Zhang, Linyin Feng
Histone deacetylase 4 (HDAC4) is a class II HDAC which is highly expressed in the brain. Previous reports have shown that HDAC4 is essential for normal brain physiology and its deregulation leads to several neurodegenerative disorders. However, it remains unclear whether dysregulation of HDAC4 is specifically involved in the development of Parkinson's disease. In this study, we demonstrate that intracellular trafficking of HDAC4 is important in regulating dopaminergic cell death. While HDAC4 normally localizes to the cytoplasm, nuclear accumulation of HDAC4 was observed in dopaminergic neurons overexpressing A53T mutant α-synuclein treated with MPP(+)/MPTP in vitro and in vivo...
October 26, 2016: Molecular Neurobiology
Takeshi Ichikawa, Nobuaki Machida, Hiroshi Sasaki, Akira Tenmoku, Hiroaki Kaneko, Ryoju Negishi, Itaru Oi, Masayuki A Fujino
OBJECTIVE: We examined early predictors of the outcome in hepatocellular carcinoma (HCC) patients after transarterial chemoembolization (TACE). METHODS: We analyzed 116 patients with unresectable HCC treated with initial TACE. α-Fetoprotein (AFP) or des-γ-carboxy prothrombin (DCP) response was assessed in patients who had baseline AFP levels ≥200 ng/ml or DCP ≥60 mAU/ml; a positive response was defined as a reduction of >50% compared to baseline 1 month after TACE...
2016: Oncology
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