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Francesco Boschetto, Nami Toyama, Satoshi Horiguchi, Ryan M Bock, Bryan J McEntire, Tetsuya Adachi, Elia Marin, Wenliang Zhu, Osam Mazda, B Sonny Bal, Giuseppe Pezzotti
The metabolic response of Gram-positive Staphylococcus epidermidis (S. epidermidis) bacteria to bioceramic substrates was probed by means of Fourier transform infrared spectroscopy (FTIR). Oxide zirconia-toughened alumina (ZTA) and non-oxide silicon nitride (Si3N4) substrates were tested. Bacteria exposed to silica glass substrates were used as a control. S. epidermidis, a major cause of periprosthetic infections, was screened to obtain a precise time-lapse knowledge of its molecular composition and to mechanistically understand its interaction with different substrates...
April 18, 2018: Analyst
Simone Haastrup, Maja Hellfritzsch, Lotte Rasmussen, Anton Pottegård, Erik Lerkevang Grove
We aimed to provide detailed utilization data on the total use of non-vitamin K antagonist oral anticoagulants (NOACs) since their introduction in 2008. Using the nationwide Danish National Prescription Registry, we identified all individuals filling prescriptions for NOACs 2008-2016. We reported the development in incident and prevalent users and explored baseline characteristics and treatment persistence according to treatment indication. A total of 126,691 NOAC users were identified within the Danish population of 5...
April 17, 2018: Basic & Clinical Pharmacology & Toxicology
Xiang Li, Qi Zhang, Jiyuan Dong, Guoqiang Zhang, Wei Chai, Jiying Chen
INTRODUCTION: There is growing support in the literatures that peri-operative outcomes are adversely affected by surgical case order in some certain surgical procedures. This study aimed to examine if similar phenomenon is also shared in total joint arthroplasty (TJA). METHODS: A total of 6548 joints (5183 patients) treated with primary TJA by a total of five surgeons at our institution from December 2011 to December 2015 were retrospectively reviewed in this study...
February 14, 2018: International Orthopaedics
M H M Nascimento, M K K D Franco, F Yokaichyia, E de Paula, C B Lombello, D R de Araujo
In this study, we reported the hyaluronic acid (HA) on supramolecular structure of Pluronic F-127 (PLF-127) and/or Pluronic F-108 (PLF-127) hydrogels, as well as their effects on release mechanisms, looking forward their application as lidocaine (LDC) drug-delivery systems in arthroplastic surgeries. We have studied the HA-micelle interaction using Dynamic Light Scattering (DLS), the micellization and sol-gel transition processes by Differential Scanning Calorimetry (DSC) and Rheology., of PL-based hydrogels and...
May 2018: International Journal of Biological Macromolecules
Kasper Højgaard Thybo, Janus Christian Jakobsen, Daniel Hägi-Pedersen, Niels Anker Pedersen, Jørgen Berg Dahl, Henrik Morville Schrøder, Hans Henrik Bülow, Jan Gottfrid Bjørck, Søren Overgaard, Ole Mathiesen, Jørn Wetterslev
BACKGROUND: Effective postoperative pain management is essential for the rehabilitation of the surgical patient. The PANSAID trial evaluates the analgesic effects and safety of the combination of paracetamol and ibuprofen. This paper describes in detail the statistical analysis plan for the primary publication to prevent outcome reporting bias and data-driven analysis results. METHODS/DESIGN: The PANSAID trial is a multicentre, randomised, controlled, parallel, four-group clinical trial comparing the beneficial and harmful effects of different doses and combinations of paracetamol and ibuprofen in patients having total hip arthroplastic surgery...
October 10, 2017: Trials
Madoka Ikemoto-Uezumi, Yasumoto Matsui, Masaki Hasegawa, Remi Fujita, Yasuhide Kanayama, Akiyoshi Uezumi, Tsuyoshi Watanabe, Atsushi Harada, A Robin Poole, Naohiro Hashimoto
Muscle dysfunction is the most important modifiable mediating factor in primary osteoarthritis (OA) because properly contracting muscles are a key absorber of forces acting on a joint. However, the pathological features of disuse muscle atrophy in OA patients have been rarely studied. Vastus medialis muscles of 14 female patients with OA (age range, 69 to 86 years), largely immobile for 1 or more years, were obtained during arthroplastic surgery and analyzed histologically. These were compared with female patients without arthritis, two with patellar fracture and two with patellar subluxation...
December 2017: American Journal of Pathology
Ching-Hou Ma, Chin-Hsien Wu, I-Ming Jou, Yuan-Kun Tu, Ching-Hsia Hung, Pei-Ling Hsieh, Kun-Ling Tsai
Osteoarthritis (OA) is a degenerative joint disease affecting a large population of people. Although the elevated expression of PKR (double stranded RNA-dependent protein kinase) and MMP-13 (collagenase-3) have been indicated to play pivotal roles in the pathogenesis of OA, the exact mechanism underlying the regulation of MMP-13 by PKR following inflammatory stimulation was relatively unknown. The purpose of this study was to determine the signaling pathway involved in the PKR-mediated induction of MMP-13 after TNF-α-stimulation...
April 2018: Redox Biology
David J Robinson, Steven Lee, Paul Marks, Michal E Schneider
Early detection of adverse local tissue reaction (ALTR) to prosthetic hip wear debris is vital to improve the success of revision surgery. Magnetic resonance imaging with metal artefact reduction sequencing (MARS MRI) is considered the modality of choice to provide cross-sectional imaging of the soft tissues. The areas adjacent to the prosthesis are, however, not readily imaged using these protocols. Ultrasound has also been recommended as an imaging modality in the follow-up of hip replacement surgery. We decided to characterise the typical ultrasound findings in a group of patients undergoing routine biennial review of arthroplastic hips with particular reference to the hip capsule, femoral neck and iliopsoas bursa and tendon adjacent to the implant...
July 2017: Ultrasound in Medicine & Biology
Andreas Toepfer, Norbert Harrasser, Isabel Petzschner, Florian Pohlig, Ulrich Lenze, Ludger Gerdesmeyer, Dominik Pförringer, Marcel Toepfer, Marc Beirer, Moritz Crönlein, Ruediger von Eisenhart-Rothe, Heinz Mühlhofer
BACKGROUND: Compromised bone stock and heavily impaired structural integrity after multiple endoprosthetic revision surgeries can lead to a comparable condition as encountered in musculoskeletal tumor surgery. Total femoral replacement (TFR) can restore femoral integrity and allow patients to resume ambulation. Even though several authors reported their results of TFR, so far many questions are still on debate: Which patients are at risk to experience low functional outcome? Do complications and clinical outcome after TFR depend on the indication for the surgery (e...
December 12, 2016: BMC Musculoskeletal Disorders
Sophie Arbefeville, Anthony Harris, Steven Dittes, Patricia Ferrieri
OBJECTIVES: To identify the gram-negative rods grown from blood cultures and a right-knee fluid aspirate from an 80-year-old caucasian man who had undergone a total right knee arthroplastic procedure 6 years ago, and to assess the genetic similarity between the 2 isolates. METHODS: We used 3 different approaches: biochemical testing, matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry, and 16S ribosomal RNA (rRNA) gene sequencing...
August 2016: Laboratory Medicine
Gerrit Steffen Maier, Uwe Maus, Djordje Lazovic, Konstantin Horas, Klaus Edgar Roth, Andreas Alois Kurth
BACKGROUND: The purpose of this observational study was to evaluate serum levels of 25-OH-D in patients scheduled to undergo elective hip or knee arthroplasty. We hypothesised that 25-OH-D level is an independent risk factor for length of stay in orthopaedic patients after elective hip or knee arthoplasty. MATERIALS AND METHODS: 25-OH-D levels were measured in 1083 patients admitted to an orthopaedic surgery department to undergo elective hip or knee arthroplasty...
December 2016: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
Julie K Cremeans-Smith, Kenneth Greene, Douglas L Delahanty
OBJECTIVE: The severe pain and disability associated with osteoarthritis often motivate individuals to undergo arthroplastic surgery. However, a significant number of surgical patients continue to experience pain following surgery. Prior research has implicated both the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) in the sensitization of pain receptors and chronic pain conditions. This study uses a prospective, observational, cohort design to examine whether physiological stress responses before and after surgery could predict post-operative pain severity...
May 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
A L Chellappa, D Mehrotra, K Vishwakarma, N Mahajan, D P Bhutia
INTRODUCTION: In cases of temporomandibular joint (TMJ) ankylosis, interposition arthroplasty allows return of functional jaw movements. In order to improve the facial appearance, distraction osteogenesis is the treatment of choice, and may be timed either as a pre-arthroplastic, simultaneous or post-arthroplastic procedure. This study was planned to compare the treatment outcomes of pre-arthroplastic distraction (PAD) and simultaneous arthroplastic distraction (SAD) to establish the better treatment modality in terms of improvement in function and aesthetics...
September 2015: Journal of Oral Biology and Craniofacial Research
Yun-Chuan Mao, Shih-Tse Chen, Chung-Hwan Chen, Kun-Pin Hsieh, Kim-Hong Gan
Venous thromboembolism (VTE) is one of the severe complications of total hip arthroplasty (THA) and total knee arthroplasty (TKA). The incidence of VTE could be reduced if preventive antithrombotic medicines are used; however, the incidence of bleeding may increase. Rivaroxaban is a factor Xa inhibitor that prevents VTE after THA or TKA. This study is designed to confirm the efficacy and safety of rivaroxaban in Taiwan. This is a retrospective database study based on the data of 6996 patients provided by the Taiwan National Health Insurance Research Database from 2008 to 2012...
October 2015: Kaohsiung Journal of Medical Sciences
Denis Katz, Philippe Valenti, Jean Kany, Kamil Elkholti, Jean-David Werthel
PURPOSE: Our purpose was to evaluate the influence of metallic lateralisation of the centre of rotation (COR) in reverse shoulder arthroplasty (RSA) on the incidence of scapular notching and its eventual clinical and radiological consequences. METHODS: We analysed 140 RSAs with a lateralised design (Arrow, FH Orthopedics, Mulhouse, France) implanted for massive rotator cuff tear with/without arthritis. Mean follow-up was 45 months (range 24-120, standard deviation 20)...
January 2016: International Orthopaedics
Funda Büyükyılmaz, Merdiye Şendir, Ricky Autar, İlknur Yazgan
Deep vein thrombosis (DVT) is a prevalent problem for orthopedic patients, particularly owing to the nature of operative interventions and treatment procedures, predisposing to an high risk of DVT. This descriptive study was conducted to determine the levels of risk, the risk factors, and their odds ratio for DVT in patients undergoing major orthopedic surgery. Data were collected using a Patient Information Form and the Autar DVT Risk Assessment Scale (DVTRAS) in orthopedic wards of a university hospital on postoperative day 2...
September 2015: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
Walter Ricioli, Marcelo Cavalheiro Queiroz, Rodrigo Pereira Guimarães, Emerson K Honda, Giancarlo Polesello, Patricia M de Moraes Barros Fucs
PURPOSE: The purpose of this study was to identify the frequency and type of intra-operative periprosthetic fractures and to describe risk factors in a single tertiary, public hospital, so that these events could be prevented, even among less experienced surgeons. METHODS: This is a cross-sectional study, based on medical records and imaging exams from the archives of a public, tertiary hospital, from April 1998 to October 2013. All consecutive patients submitted to total hip arthroplasty (THA) in the study period were evaluated, excluding unipolar or bipolar arthroplasty, surgery for the osteosynthesis of periprosthetic fractures, surgical procedure to clean infection site without component substitution and not arthroplastic surgery...
October 2015: International Orthopaedics
M Moga, M E Pogarasteanu, A Barbilian
Hip arthrosis, primary or secondary, is an osteoarthritic degenerative process that affects the hip joint. Primary hip arthrosis has an unknown etiology, and secondary hip arthrosis has well defined causes; of these causes, some are known to lead to arthrosis of the hip in the young age patient. The surgical treatment aims either to preserve the patient’s hip joint, or to replace the joint. The most commonly used procedure at this time is the total hip arthroplasty. The femoral component may have a short or a long stem...
January 2015: Journal of Medicine and Life
Chi-Yang Liao, Aaron Chih-Chang Lin, Chih-Ying Lin, Tai-Kuang Chao, Tzu-Chuan Lu, Hung-Maan Lee
Osteonecrosis of the second metatarsal head is often attributed to Freiberg's disease. We describe the case of a 27-year-old Taiwanese male soldier with persistent painful disability of the right forefoot of 9 months' duration, but no history of trauma. A series of radiographs suggested the diagnosis of late-stage Freiberg's disease. The lesion was treated with interpositional arthroplasty using a palmaris longus tendon graft, in a modification of the traditional interpositional arthroplastic technique for treating Freiberg's disease...
March 2015: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Martin Faschingbauer, Heiko Reichel, Ralf Bieger, Thomas Kappe
PURPOSE: Periprosthetic infection after total hip arthroplasty is a devastating complication. A two-stage protocol with the temporary insertion of an antibiotic-laden cement spacer is the gold standard treatment for chronic infections (Clinics (Sao Paulo) 62:99-108, 2007; Clin Orthop Relat Res 427:37-46, 2004; J Arthroplast 14:175-181, 1999; Clin Orthop Relat Res 467:1848-1858, 2009; J Arthroplast 20:874-879, 2005; J Arthroplast 24: 607-613, 2009; Clin Orthop Relat Res 469:1009-1015, 2011; Hip Int 20:26-33, 2010; J Arthroplast 24:1051-1060, 2009; J Bone Joint Surg Br 91:44-51, 2009)...
May 2015: International Orthopaedics
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