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Weiyin Gao, Chenxin Ran, Jun Xi, Bo Jiao, Wenwen Zhang, Mincai Wu, Xun Hou, Zhaoxin Wu
All inorganic double metal perovskite materials have recently drawn much attention due to their three dimensionality (3D) and non-toxic nature to replace lead based perovskite material. Among all those double perovskite materials, theoretical works have demonstrated that Cs2AgBiBr6 shows high stability and possesses suitable bandgap for solar cell application. However, the film-forming ability of Cs2AgBiBr6 is found to be the utmost challenge hindering its development in thin film solar cell device. In this work, high quality Cs2AgBiBr6 film with ultra-smooth morphology, micro-sized grains, and high crystallinity is realized via anti-solvent dropping technology and post-annealing process under high temperature...
April 17, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Ruj Al-Sindy, Heleen Alaqrawy, Mahmood Sh Hafdullah, Christine Butts
Point-of-care ultrasound has become indispensable in the evaluation of trauma, particularly in low resource areas, where it may be the only rapidly available imaging modality. The FAST (Focused Assessment with Sonography in Trauma) in particular can be lifesaving, by rapidly detecting signs of intra-abdominal hemorrhage. However, the FAST is primarily designed to identify free fluid associated with solid organ injury and is thought to have less sensitivity and power in identifying evidence of hollow viscus injury...
2018: Case Reports in Emergency Medicine
Omolola C Betiku, Carl J Yeoman, T Gibson Gaylord, Benjamin Americus, Sarah Olivo, Glenn C Duff, Wendy M Sealey
A two-phase feeding study evaluating performance of rainbow trout and comparing luminal and mucosal gastrointestinal tract (GIT) bacterial community compositions when fed two alternative protein diets in two rearing systems was conducted. Alternative protein diets (animal protein and plant protein diets) balanced with crystalline amino acids: lysine, methionine and threonine or unbalanced, were fed to rainbow trout in two separate water systems (recirculating (RR) and flow-through (FF)) for a period of 16 weeks...
2018: PloS One
Divya Sunkara, Maxx Capece
This study investigated the effect of material properties, primarily particle size and surface energy, on the effectiveness of glidants used for the purpose of flowability enhancement. Three pharmaceutical grade glidants (Aerosil 200, Aerosil R972, and Cab-O-Sil M5P) were evaluated and blended with various pharmaceutical actives as well as cohesive excipients common to capsule and tablet formulation. Flowability enhancement was characterized by the flow function coefficient (ff c ). An industry-relevant mixer (Turbula mixer) and a highly efficient and effective mixer (LabRAM vibratory mixer) were used to further understand the effect of material properties on glidant effectiveness...
April 16, 2018: AAPS PharmSciTech
Yuli Yin, Jing Yang, Fengyun Guo, Erjun Zhou, Liancheng Zhao, Yong Zhang
We report three n-type polymeric electron acceptors (PFPDI-TT, PFPDI-T and PFPDI-Se) based on the fused perylene diimide (FPDI) and thieno[3,2-b]thiophene, thiophene or selenophene units for all-polymer solar cells (all-PSCs). These FPDI-based polymer acceptors exhibit the strong absorption between 350 nm and 650 nm with the wide optical badgaps of 1.86~1.91 eV, showing good absorption compensation with the narrow bangap polymer donor. The lowest unoccupied molecular orbital (LUMO) energy levels were located at around -4...
April 16, 2018: ACS Applied Materials & Interfaces
Luigino Calzetta, Maria Gabriella Matera, Francesco Facciolo, Mario Cazzola, Paola Rogliani
BACKGROUND: Corticosteroids increase the expression of β2 -adrenoceptors (β2 -ARs) and protect them against down-regulation. Conversely, β2 -AR agonists improve the anti-inflammatory action of corticosteroids. Nevertheless, it is still uncertain whether adding a long-acting β2 -AR agonist (LABA) to an inhaled corticosteroid (ICS) results in an additive effect, or there is true synergy. Therefore, the aim of this study was to pharmacologically characterize the interaction between the ICS beclomethasone diproprionate (BDP) and the LABA formoterol fumarate (FF) in a validated human ex vivo model of bronchial asthma...
April 12, 2018: Respiratory Research
Haiyang Zhang, Chunhua Yin, Yang Jiang, David van der Spoel
Thermodynamic and kinetic properties are of critical importance for the applicability of computational models to biomolecules such as proteins. Here we present an extensive evaluation of the Amber ff99SB-ILDN force field for modeling hydration and diffusion of amino acids with three-site (SPC, SPC/E, SPC/Eb, and TIP3P), four-site (TIP4P, TIP4P-Ew, and TIP4P/2005), and five-site (TIP5P and TIP5P-Ew) water models. Hydration free energies (HFEs) of neutral amino acid side chain analogues have little dependence on the water models with a root-mean-square error (RMSE) of ~1 kcal/mol from experimental observations...
April 12, 2018: Journal of Chemical Information and Modeling
Suvi M Manninen, Maria A Lankinen, Vanessa D de Mello, David E Laaksonen, Ursula S Schwab, Arja T Erkkilä
SCOPE: Intake of long-chain n-3 PUFAs affects the lipoprotein subclass profile, whereas the effect of shorter chain n-3 PUFAs remains unclear. We investigated the effect of fish and camelina sativa oil (CSO) intakes on lipoprotein subclasses. METHODS AND RESULTS: Altogether 79 volunteers with impaired glucose metabolism were randomly assigned to CSO, fatty fish (FF), lean fish (LF) or control group for 12 weeks. Nuclear magnetic resonance spectroscopy was used to determine lipoprotein subclasses and their lipid components...
April 12, 2018: Molecular Nutrition & Food Research
Efstratios D Sitsanidis, Carmen C Piras, Bruce D Alexander, Giuliano Siligardi, Tamás Jávorfi, Andrew J Hall, Alison A Edwards
Circular dichroism (CD) spectroscopy has been used extensively for the investigation of the conformation and configuration of chiral molecules, but its use for evaluating the mode of self-assembly in soft materials has been limited. Herein, we report a protocol for the study of such materials by electronic CD spectroscopy using commercial/benchtop instruments and synchrotron radiation (SR) using the B23 beamline available at Diamond Light Source. The use of the B23 beamtime for SRCD was advantageous because of the unique enhanced spatial resolution achieved because of its highly collimated and small beamlight cross section (ca...
April 12, 2018: Chirality
Nadine Mengis, Antti-Ilari Partanen, Jonathan Jalbert, H Damon Matthews
Estimates of the 1.5 °C carbon budget vary widely among recent studies, emphasizing the need to better understand and quantify key sources of uncertainty. Here we quantify the impact of carbon cycle uncertainty and non-CO2 forcing on the 1.5 °C carbon budget in the context of a prescribed 1.5 °C temperature stabilization scenario. We use Bayes theorem to weight members of a perturbed parameter ensemble with varying land and ocean carbon uptake, to derive an estimate for the fossil fuel (FF) carbon budget of 469 PgC since 1850, with a 95% likelihood range of (411,528) PgC...
April 11, 2018: Scientific Reports
Chengcheng Han, Guanghua Xu, Jun Xie, Chaoyang Chen, Sicong Zhang
Visual evoked potential-based brain-computer interfaces (BCIs) have been widely investigated because of their easy system configuration and high information transfer rate (ITR). However, the uncomfortable flicker or brightness modulation of existing methods restricts the practical interactivity of BCI applications. In our study, a flicker-free steady-state motion visual evoked potential (FF-SSMVEP)-based BCI was proposed. Ring-shaped motion checkerboard patterns with oscillating expansion and contraction motions were presented by a high-refresh-rate display for visual stimuli, and the brightness of the stimuli was kept constant...
April 11, 2018: Scientific Reports
Karim Bahadurali Samji, Ania Zofia Kielar, Michael Connolly, Najla Fasih, Geoffrey Doherty, Andrew Chung, Etienne Hache
OBJECTIVE: The objective of our study was to evaluate the diagnostic performance of CT in the identification of anastomotic leaks. MATERIALS AND METHODS: This was a study of patients who underwent bowel surgery and a subsequent postoperative CT examination performed specifically for investigating for an anastomotic leak. The study group included patients with surgically confirmed anastomotic leaks (n = 59), and the control group included patients without anastomotic leaks (n = 48) confirmed by either repeat surgery or uneventful clinical follow-up for at least 6 months...
April 9, 2018: AJR. American Journal of Roentgenology
O Muñoz, C Fuentealba, D Ampuero, F Figuerola, A M Estévez
Secoisolariciresinol (SECO) is present in flaxseeds as a glucoside, secoisolariciresinol diglucoside (SDG), which can be metabolized to enterodiol (ED) and enterolactone (EL) by the human intestinal microbiota. The aim of this study was to evaluate the effect of Lactobacillus casei and Lactobacillus acidophilus on the bioaccessibility of flaxseed lignans from a complete in vitro digestion of whole flaxseeds (WFs) and flaxseed flour (FF). Lignans are only detected in the large intestine. The bioaccessibility of SDG for FF digestion can be ordered as follows: control (without probiotics) > L...
April 9, 2018: Food & Function
Mohamed A Korany, Hoda Mahgoub, Rim S Haggag, Marwa A A Ragab, Osama A Elmallah
A green, simple and cost effective chemometric UV-Vis spectrophotometric method has been developed and validated for correcting interferences that arise during conducting biowaiver studies. Chemometric manipulation has been done for enhancing the results of direct absorbance, resulting from very low concentrations (high incidence of background noise interference) of earlier points in the dissolution timing in case of dissolution profile using first and second derivative (D1 & D2) methods and their corresponding Fourier function convoluted methods (D1/FF& D2/FF)...
March 27, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Xuemei Dong, Dong Chen, Junshuai Zhou, Yan-Zhen Zheng, Xia Tao
ZnO as a promising electron transport layer (ETL) to TiO2 for perovskite solar cells (PSCs) has achieved a power conversion efficiency (PCE) of 18.9%; however, this is still lower than that obtained for TiO2-based PSCs (higher than 20%). Herein, we report the fabrication of high-efficiency methylammonium (MA) and Cs co-alloyed formamidinium (FA) triple cation perovskite based ZnO PSCs via delicate control of the cation compositions and annealing temperatures. By virtue of structural, morphological, spectral and electrochemical characterizations and analysis, we found that the incorporation of MA and Cs into FA perovskite enables the formation of a highly crystalline black phase perovskite with reduced surface roughness, which inhibits charge recombination and promotes electron transfer at the ZnO/perovskite/spiro-OMeTAD interfaces and hence improves Jsc and FF values of the cell...
April 6, 2018: Nanoscale
Emily R Watkins, Mark Hayes, Peter Watt, Alan J Richardson
Analysis of Fire Service Instructors (FSI) working practices and health is needed to minimise health risks related to heat illness, cardiovascular events and immunological stress. Online surveys were distributed to UK FSI and Firefighters (FF). One hundred and thirty FSI (age: 43±7yrs) and 232 FF (age: 41±8yrs) responded. FSI experienced 2-10 live fires per week, with 45% of FSI reporting management does not set a limit on the number of exposures. Few FSI followed hydration guidelines, or cooling methods...
April 5, 2018: Archives of Environmental & Occupational Health
Eric Bonnet, Marie-Laure Moutet, Céline Baulard, Delphine Bacq-Daian, Florian Sandron, Lilia Mesrob, Bertrand Fin, Marc Delépine, Marie-Ange Palomares, Claire Jubin, Hélène Blanché, Vincent Meyer, Anne Boland, Robert Olaso, Jean-François Deleuze
Next-generation sequencing (NGS) studies are becoming routinely used for the detection of novel and clinically actionable DNA variants at a pangenomic scale. Such analyses are now used in the clinical practice to enable precision medicine. Formalin-fixed paraffin-embedded (FFPE) tissues are still one of the most abundant source of cancer clinical specimen, unfortunately this method of preparation is known to degrade DNA and therefore compromise subsequent analysis. Some studies have reported that variant detection can be performed on FFPE samples sequenced with NGS techniques, but few or none have done an in-depth coverage analysis and compared the influence of different state-of-the-art FFPE DNA extraction kits on the quality of the variant calling...
2018: PloS One
S Spanou, D Kalogiannis, E Zapanti, M Gazouli, I A Sfontouris, C Siristatidis, George Mastorakos
PURPOSE: To calculate the concentrations of interleukin 15 (IL-15) in follicular fluid (FF) and evaluate their relation with oocyte maturation, follicle size, and patients' body mass index (BMI) and age. METHODS: Follicular fluid specimens were obtained from 56 subfertile women undergoing intracytoplasmic sperm injection (ICSI) during oocyte retrieval for measurement of IL-15 concentrations with ELISA. Wilcoxon's test and Pearson's correlation coefficient were used to correlate FF concentrations of IL-15 with follicular size and stage of oocyte maturation, along with patients' BMI and age...
April 4, 2018: Journal of Assisted Reproduction and Genetics
Kazuki Kansaku, Yasuhisa Munakata, Nobuhiko Itami, Koumei Shirasuna, Takehito Kuwayama, Hisataka Iwata
This study examined the concentration of cell-free mitochondrial DNA (cf-mtDNA) in porcine follicular fluid (FF) and explored whether the cfDNA level in the culture medium could reflect mitochondrial dysfunction in cumulus cell-oocyte complexes (COCs). cfDNA concentration was higher in the fluid of small-sized follicles, compared to that in larger follicles. The length of cfDNA ranged from short (152 bp) to long (1,914 bp) mtDNA in FF, detected by polymerase chain reaction (PCR). cfDNA concentration in FF significantly correlated with the mtDNA copy number in FF but not with the number of one-copy gene (nuclear DNA) in FF...
April 3, 2018: Journal of Reproduction and Development
Hyeonseok Lee, Yu-Ting Huang, Mark W Horn, Shien-Ping Feng
Inverted perovskite solar cells incorporating RF sputtered NiO thin films as a hole transport layer and window layer are demonstrated. The electrical and optical properties of the NiO thin films are engineered using varied sputtering conditions. The localized states within bandgap owing to its crystal disorder and nonstoichiometric features affect the transmittance and the optical bandgap of the NiO thin films which in turn influences the Jsc of the perovskite solar cells. In addition, the electrical properties of the NiO thin films can be also varied during sputtering condition affecting the concentration of nickel vacancies and the resulting hole concentration...
April 3, 2018: Scientific Reports
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