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https://www.readbyqxmd.com/read/29455394/culture-in-embryonic-kidney-serum-and-xeno-free-media-as-renal-cell-carcinoma-and-renal-cell-carcinoma-cancer-stem-cells-research-model
#1
Krzysztof M Krawczyk, Damian Matak, Lukasz Szymanski, Cezary Szczylik, Camillo Porta, Anna M Czarnecka
The use of fetal bovine serum hinders obtaining reproducible experimental results and should also be removed in hormone and growth factor studies. In particular hormones found in FBS act globally on cancer cell physiology and influence transcriptome and metabolome. The aim of our study was to develop a renal carcinoma serum free culture model optimized for (embryonal) renal cells in order to select the best study model for downstream auto-, para- or endocrine research. Secondary aim was to verify renal carcinoma stem cell culture for this application...
February 17, 2018: Cytotechnology
https://www.readbyqxmd.com/read/29451857/micrornas-as-predictive-biomarkers-of-response-to-tyrosine-kinase-inhibitor-therapy-in-metastatic-renal-cell-carcinoma
#2
Julia Kovacova, Alexandr Poprach, Tomas Buchler, William C Cho, Ondrej Slaby
Renal cell carcinoma (RCC) accounts for 2%-3% of all malignant tumours. The first-choice treatment in metastatic RCC (mRCC) patients is tyrosine kinase inhibitors (TKIs). Although TKIs may prolong survival of the treated patients who are not primary resistant, almost all of them will eventually develop secondary resistance to the treatment after a progression-free period. To predict treatment response, thus, we need efficient biomarkers for rational indication of TKIs in mRCC. MicroRNAs (miRNAs) not only play important roles in the pathogenesis of many cancers, including RCC but also have been shown to serve as promising diagnostic, prognostic and predictive biomarkers in various cancers...
February 16, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29449739/nasal-metastasis-as-the-first-manifestation-of-a-metachronous-bilateral-renal-cell-carcinoma
#3
A Serra, R Caltabiano, A Giorlandino, A Musumeci, A Conti, G Zanghì, A Maniaci, S Cocuzza
Renal cell carcinoma is one of the most common tumours to spread by extranodal metastases to the head and neck. Metastatic renal cell carcinoma to the head and neck area has been demonstrated mostly in the paranasal sinuses, parotid gland, the mandible, larynx and hypopharinx. Renal cell carcinoma should be excluded whenever a metastatic lesion is encountered in the head and neck area, even if the metastatic lesion is the first clinical presentation. The diagnosis of metastatic RCC should be suspected in any patient with even a remote history of renal cell carcinoma...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29446832/an-assessment-of-18-f-fdg-pet-ct-for-thoracic-screening-and-risk-stratification-of-pulmonary-nodules-in-multiple-endocrine-neoplasia-type-1
#4
Alvin So, Owen Pointon, Richard Hodgson, John Burgess
CONTEXT: Bronchopulmonary neuroendocrine tumours (bpNETs) and thymic carcinoid (ThC) are features of Multiple Endocrine Neoplasia Type 1 (MEN 1) and surveillance guidelines recommend periodic thoracic imaging. The optimal thoracic imaging modality and screening frequency remains uncertain as does the prognosis of small lung nodules when identified. OBJECTIVES: To evaluate fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) for identification and prognostic assessment of thoracic lesions in MEN 1...
February 15, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29440231/-ex-vivo-activity-of-cytotoxic-drugs-and-targeted-agents-in-small-intestinal-nets
#5
Kosmas Daskalakis, Olov Norlen, Andreas Karakatsanis, Per Hellman, Rolf Larsson, Peter Nygren, Peter Stalberg
Small intestinal endocrine tumours (SI-NETs) are generally considered resistant to systemic treatment. To date, predictive markers for drug activity are lacking. Tumour samples from 27 patients with SI-NETs were analyzed ex vivo for sensitivity to a panel of cytotoxic drugs and targeted agents using a short-term total cell kill assay. Samples of renal cancer, colorectal cancer (CRC), ovarian cancer, and chronic lymphocytic leukemia (CLL) were included for comparison. For the SI-NET subset, drug sensitivity was analyzed in relation to clinico-pathological variables and pre-treatment biomarkers...
February 12, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29439857/axitinib-in-combination-with-pembrolizumab-in-patients-with-advanced-renal-cell-cancer-a-non-randomised-open-label-dose-finding-and-dose-expansion-phase-1b-trial
#6
Michael B Atkins, Elizabeth R Plimack, Igor Puzanov, Mayer N Fishman, David F McDermott, Daniel C Cho, Ulka Vaishampayan, Saby George, Thomas E Olencki, Jamal C Tarazi, Brad Rosbrook, Kathrine C Fernandez, Mariajose Lechuga, Toni K Choueiri
BACKGROUND: Previous studies combining PD-1 checkpoint inhibitors with tyrosine kinase inhibitors of the VEGF pathway have been characterised by excess toxicity, precluding further development. We hypothesised that axitinib, a more selective VEGF inhibitor than others previously tested, could be combined safely with pembrolizumab (anti-PD-1) and yield antitumour activity in patients with treatment-naive advanced renal cell carcinoma. METHODS: In this ongoing, open-label, phase 1b study, which was done at ten centres in the USA, we enrolled patients aged 18 years or older who had advanced renal cell carcinoma (predominantly clear cell subtype) with their primary tumour resected, and at least one measureable lesion, Eastern Cooperative Oncology Group performance status 0-1, controlled hypertension, and no previous systemic therapy for renal cell carcinoma...
February 9, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29436848/image-guided-biopsy-of-small-%C3%A2-4cm-renal-masses-the-effect-of-size-and-anatomical-location-on-biopsy-success-rate-and-complications
#7
Matthew Seager, Uday Patel, Christopher Anderson, Michael Gonsalves
Objective To study the influence of tumour diameter and anatomy on the success and complication rates of small renal mass (SRM,≤4 cm) core biopsy Methods Retrospective analysis of SRMs that underwent ultrasound or computed tomography-(CT) guided biopsy. Diagnostic and complication rates were compared according to tumour size (sub-categorised as axial diameter ≤2 cm,>2 to≤3 cm,>3 to≤4 cm) and anatomical disposition (exophytic/endophytic, centrality, polar location and anterior/posterior). Results Ninety-four patients (54 male; age range 21...
February 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29435287/secondary-tumours-of-the-ampulla-of-vater-case-report-and-review-of-the-literature
#8
Francesca Sarocchi, Magdalena M Gilg, Florian Schreiber, Cord Langner
Secondary tumours of the ampulla of Vater are rare. Underlying primary tumours, clinical presentation, macroscopic appearance, treatment strategies and outcome of secondary ampullary lesions have not been systematically analysed. The present case study reported a 57-year old patient with an ampullary metastasis from renal cancer and a literature review was performed in which a further 32 patients were included. The most common responsible primary tumours were malignant melanoma and renal clear cell carcinoma, followed by breast cancer...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29429912/denosumab-versus-zoledronic-acid-in-bone-disease-treatment-of-newly-diagnosed-multiple-myeloma-an-international-double-blind-double-dummy-randomised-controlled-phase-3-study
#9
Noopur Raje, Evangelos Terpos, Wolfgang Willenbacher, Kazuyuki Shimizu, Ramón García-Sanz, Brian Durie, Wojciech Legieć, Marta Krejčí, Kamel Laribi, Li Zhu, Paul Cheng, Douglas Warner, G David Roodman
BACKGROUND: Multiple myeloma is characterised by monoclonal paraprotein production and osteolytic lesions, commonly leading to skeletal-related events (spinal cord compression, pathological fracture, or surgery or radiotherapy to affected bone). Denosumab, a monoclonal antibody targeting RANKL, reduces skeletal-related events associated with bone lesions or metastases in patients with advanced solid tumours. This study aimed to assess the efficacy and safety of denosumab compared with zoledronic acid for the prevention of skeletal-related events in patients with newly diagnosed multiple myeloma...
February 8, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29429069/rare-and-changeable-as-a-chameleon-paraneoplastic-syndromes-in-renal-cell-carcinoma
#10
REVIEW
M Hegemann, N Kroeger, A Stenzl, J Bedke
INTRODUCTION: Paraneoplastic syndromes (PNS) in renal cell carcinoma (RCC) are important to be recognized by the treating physician, because they may lead to diagnosis of underlying malignant disease. On the other hand, PNS may dominate the clinical picture and can hide the true disorder like a chameleon. When realized, a PNS can be used as a 'neoplastic tumour marker', especially in case of recurrence. Their occurrence can even be linked to prognosis of disease. METHODS: A PubMed search combining the MeSH terms renal cell carcinoma and paraneoplastic syndrome was executed in April 2015...
February 10, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29426988/rfa-versus-robotic-partial-nephrectomy-for-t1a-renal-cell-carcinoma-a-propensity-score-matched-comparison-of-mid-term-outcome
#11
Byung Kwan Park, In Hyuck Gong, Min Yong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Soo Jeon, Hyun Moo Lee, Seong Il Seo
OBJECTIVE: To compare oncological and functional mid-term outcomes following robotic partial nephrectomy (RPN) and radiofrequency ablation (RFA) for treating T1a renal cell carcinoma (RCC) using propensity score-matching. METHODS: Between December 2008-April 2016, 63 patients from each treatment group were propensity score-matched for age, sex, American Society of Anesthesiologists score, tumour size, tumour laterality, tumour histology, R.E.N.A.L. nephrometry score and preoperative estimated glomerular filtration rate (eGFR)...
February 9, 2018: European Radiology
https://www.readbyqxmd.com/read/29426046/-severe-thoracic-bleeding-25-years-after-nephrectomy
#12
H Rupprecht, H Dormann, A Marx, K Gaab
We report a case of a 62 year old patient, who was hospitalised due to haemorrhagic shock. The cause was a rupture of the pulmonary artery due to metastasis of a renal cell carcinoma. This cause is now reported for the first time. The primary tumour (pT2,pN0,M0,R0) was resected 25 years ago. This case demonstrates that after curative nephrectomy pulmonary metastasis can occur, even after decades. This is why patients of this type need lifelong follow-up.
February 9, 2018: Aktuelle Urologie
https://www.readbyqxmd.com/read/29416602/the-prognostic-significance-of-nuclear-expression-of-phf2-and-c-ebp%C3%AE-in-clear-cell-renal-cell-carcinoma-with-consideration-of-adipogenic-metabolic-evolution
#13
Jeong Hwan Park, Minsun Jung, Kyung Chul Moon
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), and it has an unfavourable prognosis compared to other RCCs. Plant homeodomain finger 2 (PHF2) and CCATT/enhancer binding protein α (C/EBPα) play a role in the epigenetic regulation of adipogenesis, and their tumour suppressive functions have been elucidated. This study aimed to assess the nuclear expression of PHF2 and C/EBPα in ccRCC and to evaluate their role in pathogenesis and prognosis. The nuclear expression of PHF2 and C/EBPα was evaluated in 344 cases of ccRCC by immunohistochemistry, and adipogenesis was assessed based on cytoplasmic features...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29413689/germline-bap1-positive-patients-the-dilemmas-of-cancer-surveillance-and-a-proposed-interdisciplinary-consensus-monitoring-strategy
#14
Phoebe Star, Annabel Goodwin, Rony Kapoor, R Max Conway, Georgina V Long, Richard A Scolyer, Pascale Guitera
The germline BAP1 (BRCA1-associated protein-1) mutation and associated cancer pre-disposition syndrome was first described in 2011. Since then, physicians have considered this diagnosis for patients with a characteristic personal or family history of BAP1-associated tumours (mainly uveal and cutaneous melanoma, pleural/peritoneal mesothelioma, renal cell carcinoma and BAP1-deficient melanocytic lesions). However, a positive germline BAP1 mutation detection creates significant uncertainty in terms of appropriate cancer surveillance...
February 2, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29409504/unusual-progression-of-renal-cell-carcinoma-with-carcinomatosis-peritoneii-and-krukenberg-tumour-and-alopecia-with-sunitinib-therapy-in-young-female
#15
Manoj Pandey, Mahendran Ramasamy, Mridula Shukla
BACKGROUND: Sunitinib is a multiple receptor tyrosine kinase inhibitor (TKI) used for the treatment of renal cell carcinoma (RCC). It increases the median survival considerably with minimum side effects. Alopecia is one of the rare side effects. Metastasis to the ovary is also rare. We report a case of RCC metastasizing to the ovary developing alopecia early on starting sunitinib. CASE PRESENTATION: A 22-year-old hypothyroid girl underwent right radical nephrectomy for T2N0 RCC...
February 6, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29406830/triiodothyronine-attenuates-the-progression-of-renal-injury-in-a-rat-model-of-chronic-kidney-disease
#16
Sahar Mohamed El Agaty
This study was designed to investigate whether and how triiodothyronine (T3) affects renal function in an experimental model of chronic kidney disease. Twenty four female rats were divided into: sham operated control group (n=8) , 5/6 nephrectomized group (Nx, n=8) and 5/6 nephrectomized group treated with T3 for 2 weeks (T3-Nx, n=8). T3 administration significantly decreased serum levels of urea, creatinine, tumour necrosis factor alpha, and interleukin-6 compared to Nx group. The levels of malondialdehyde , transforming growth factor beta, fibronectin, and collagen IV as well as the expression of inducible nitric oxide synthase, nuclear factor kappa B, poly ADP ribose polymerase, caspase-3 and Bax all were significantly decreased , though not normalized, in the remnant kidney of T3-Nx group compared to Nx rats...
February 6, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29406185/differential-effects-of-sevoflurane-on-the-metastatic-potential-and-chemosensitivity-of-non-small-cell-lung-adenocarcinoma-and-renal-cell-carcinoma-in-vitro
#17
S Ciechanowicz, H Zhao, Q Chen, J Cui, E Mi, E Mi, Q Lian, D Ma
BACKGROUND: Increasing evidence suggests that perioperative factors including anaesthetics influence cancer recurrence and metastasis after surgery. This study investigated the influence of sevoflurane on the response of lung and renal cancer cells to cisplatin, with focus on transforming growth factor-beta (TGF-β) and osteopontin (OPN) that are both closely associated with cancer tumorigenesis and metastasis. METHODS: Non-small cell lung adenocarcinoma (A549) and renal cell carcinoma (RCC4) cells were exposed to 3...
February 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29405911/evaluating-the-role-for-renal-biopsy-in-t1-and-t2-renal-masses-a-single-centre-study
#18
Dylan Hoare, Howard Evans, Heidi Richards, Rahim Samji
INTRODUCTION: Once used primarily in the identification of renal metastasis and lymphomas, various urological bodies are now adopting an expanded role for the renal biopsy. We sought to evaluate the role of the renal biopsy in a Canadian context, focusing on associated adverse events, radiographic burden, and diagnostic accuracy. METHODS: This retrospective review incorporated all patients undergoing ultrasound (US)/computed tomography (CT)-guided biopsies for T1 and T2 renal masses...
February 6, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29400663/clusterin-promotes-growth-and-invasion-of-clear-cell-renal-carcinoma-cell-by-upregulation-of-s100a4-expression
#19
Yuan Liu, Changping Men, Yingmin Xu, Kai Zhao, Lei Luo, Dahai Dong, Qinchao Yu
BACKGROUND AND OBJECTIVE: Clusterin promotes cell proliferation, motility and invasiveness in human renal cell carcinoma (RCC) cells but the underlying molecular mechanisms of this action are largely unknown. The aim of this study was to investigate the effects of clusterin on cancer cell growth, invasion and S100A4 expression and to determine the effects of clusterin on in vitro cell proliferation and migration and in vivo tumour growth in RCC cells. METHODS: We have established stable transfectants of highly invasive Caki-1 human RCC cells with expression of clusterin shRNA targeting clusterin (Caki-1/clusterin shRNA)...
January 19, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29400661/the-mediator-complex-subunit-med15-a-promoter-of-tumour-progression-and-metastatic-spread-in-renal-cell-carcinoma
#20
Richard Weiten, Tim Müller, Doris Schmidt, Susanne Steiner, Glen Kristiansen, Stefan C Müller, Jörg Ellinger, Isabella Syring
BACKGROUND/OBJECTIVE: MED15 is a part of the multiprotein Mediator complex which is involved in the transcription of polymerase (Pol) II-dependent genes. Several studies in this field have reported altered expressions of distinct subunits in human malignancy. However, the role of MED15 in renal cell carcinoma (RCC) has not be investigated yet. METHODS: First, we performed an RNA expression and survival analysis of MED15 in RCC by using the database cBioPortal. To confirm these data on the protein level, we executed immunohistochemical (IHC) staining against MED15 on a tissue microarray containing 184 samples of the most common subtypes of the tumour at the various stages...
January 19, 2018: Cancer Biomarkers: Section A of Disease Markers
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