keyword
https://read.qxmd.com/read/38523653/corrigendum-to-rpn-radius-position-of-tumour-invasion-of-renal-sinus-classification-and-nephrometry-scoring-system-an-internationally-developed-clinical-classification-to-describe-the-surgical-difficulty-for-renal-masses-for-which-robotic-partial-nephrectomy
#1
Dinesh K Agarwal, Clancy Mulholland, Digsu N Koye, Niranjan Sathianathen, Henry Yao, Philip Dundee, Daniel Moon, Marc Furrer, Christina Giudice, Wayland Wang, Julie A Simpson, Jamie Kearsley, Briony Norris, Homi Zargar, Henry Y C Pan, Alex Mottrie, Andrew Fuller, Angelo Mottaran, Ben Challacombe, Boon Kua, Charles Metcalfe, Christian Wagner, Deepak Dubey, Fernando Gomez Sancha, Franck Bruyère, Gagan Gautam, Ginil K Pooleri, Giorgio Bozzini, Howard Lau, Isaac Thyer, Jeremy Teoh, Justin Vass, Justin Vivian, Kara McDermott, Mathew Winter, Narasimhan Ragavan, Nicholas Campbell, Nina N Harke, Patrick O Richard, Patrick Teloken, Peter Dekuyper, Peter Sutherland, Rajesh Ahlawat, Rajesh Nair, Richard Pemberton, Rick Catterwell, Robert J A Oomen, Robin Weston, Rudolf Moritz, Raghunath S Krishnappa, Scott Leslie, Scott Van Appledorn, T B Yuvaraja, Thibault Meert, Thierry Dujardin, Tobias Gross, Tom Walton, William C Huang, Yves Caumartin, Ashwin Agarwal, Nathan Lawrentschuk, Niall M Corcoran
[This corrects the article DOI: 10.1016/j.euros.2023.05.007.].
May 2024: European urology open science
https://read.qxmd.com/read/38521617/avelumab-plus-intermittent-axitinib-in-previously-untreated-patients-with-metastatic-renal-cell-carcinoma-the-tide-a-phase-2-study
#2
JOURNAL ARTICLE
Roberto Iacovelli, Chiara Ciccarese, Sebastiano Buti, Paolo Andrea Zucali, Emanuela Fantinel, Davide Bimbatti, Elena Verzoni, Caterina Accettura, Lucia Bonomi, Consuelo Buttigliero, Giuseppe Fornarini, Stefania Pipitone, Francesco Atzori, Cristina Masini, Francesco Massari, Francesca Primi, Alessandro Strusi, Giulia Claire Giudice, Matteo Perrino, Marco Maruzzo, Michele Milella, Diana Giannarelli, Matteo Brunelli, Giuseppe Procopio, Giampaolo Tortora
BACKGROUND: Combinations of vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs) plus immune checkpoint inhibitor (ICI) against PD1/PD-L1 are the standard first-line therapy for patients with metastatic renal cell carcinoma (mRCC), irrespective of the prognostic class. OBJECTIVE: To investigate the feasibility and safety of withdrawing VEGFR-TKI but continuing anti-PD1/PD-L1 in patients who achieve a response to their combination...
March 22, 2024: European Urology
https://read.qxmd.com/read/38515689/identification-of-prognostic-models-for-glycosylation-related-subtypes-and-tumor-microenvironment-infiltration-characteristics-in-clear-cell-renal-cell-cancer
#3
JOURNAL ARTICLE
Cheng Shen, Bing Zheng, Zhan Chen, Wei Zhang, Xinfeng Chen, Siyang Xu, Jianfeng Ji, Xingxing Fang, Chunmei Shi
BACKGROUND: One of the most fatal forms of cancer of the urinary system, renal cell carcinoma (RCC), significantly negatively impacts human health. Recent research reveals that abnormal glycosylation contributes to the growth and spread of tumors. However, there is no information on the function of genes related to glycosylation in RCC. METHODS: In this study, we created a technique that can be used to guide the choice of immunotherapy and chemotherapy regimens for RCC patients while predicting their survival prognosis...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38514775/generation-of-synthetic-whole-slide-image-tiles-of-tumours-from-rna-sequencing-data-via-cascaded-diffusion-models
#4
JOURNAL ARTICLE
Francisco Carrillo-Perez, Marija Pizurica, Yuanning Zheng, Tarak Nath Nandi, Ravi Madduri, Jeanne Shen, Olivier Gevaert
Training machine-learning models with synthetically generated data can alleviate the problem of data scarcity when acquiring diverse and sufficiently large datasets is costly and challenging. Here we show that cascaded diffusion models can be used to synthesize realistic whole-slide image tiles from latent representations of RNA-sequencing data from human tumours. Alterations in gene expression affected the composition of cell types in the generated synthetic image tiles, which accurately preserved the distribution of cell types and maintained the cell fraction observed in bulk RNA-sequencing data, as we show for lung adenocarcinoma, kidney renal papillary cell carcinoma, cervical squamous cell carcinoma, colon adenocarcinoma and glioblastoma...
March 21, 2024: Nature Biomedical Engineering
https://read.qxmd.com/read/38512472/-urogenital-tumors-following-kidney-transplantation-monocentric-analysis-of-incidences-and-overview-of-urological-preventive-measures
#5
JOURNAL ARTICLE
J Putz, V Kestel, R Herout, A Borkowetz, S Leike, C Thomas, M Baunacke
BACKGROUND: Urogenital tumors are among the most common solid malignancies after kidney transplantation (TX). OBJECTIVE: We analyzed the incidence and mortality of urogenital tumors after kidney TX in our own patient population as well as answered the question of recommended follow-up necessity and frequency in this cohort. MATERIALS AND METHODS: Retrospective monocentric data collection of tumor diseases and the most common urogenital tumors after kidney TX at the Transplant Center Dresden between 2010 and 2020 was done...
March 21, 2024: Urologie
https://read.qxmd.com/read/38494845/cpa4-as-a-biomarker-promotes-the-proliferation-migration-and-metastasis-of-clear-cell-renal-cell-carcinoma-cells
#6
JOURNAL ARTICLE
Kongjia Wang, Yixin Ding, Yunbo Liu, Mingyu Ma, Ji Wang, Zengshun Kou, Shuo Liu, Bo Jiang, Sichuan Hou
Clear cell renal cell carcinoma (ccRCC) is a commonly occurring and highly aggressive urological malignancy characterized by a significant mortality rate. Current therapeutic options for advanced ccRCC are limited, necessitating the discovery of novel biomarkers and therapeutic targets. Carboxypeptidase A4 (CPA4) is a zinc-containing metallocarboxypeptidase with implications in various cancer types, but its role in ccRCC remains unexplored. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were utilized in order to investigate the differential expression patterns of CPA4...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38494324/successful-treatment-of-focal-renal-artery-fibromuscular-dysplasia-by-balloon-dilatation-demonstrated-via-fractional-flow-reserve
#7
Xuhe Gong, Jixuan Liu, Daokuo Yao, Rongchong Huang
We present a rare case of fibromuscular dysplasia (FMD) manifesting in the mid segment of right renal artery, which led to the development of refractory hypertension. The patient received balloon angioplasty to a severe lesion on the middle of right renal artery and subsequently had normalisation of blood pressures. Fractional flow reserve (FFR) detection of the renal artery before and after balloon dilatation was 0.71 and 0.98, respectively. The patient showed renal artery stenosis (RAS) with distal tumour-like dilatation, and multiple tortuosity and stenosis in carotid artery and coronary artery...
November 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
https://read.qxmd.com/read/38493778/ambulatory-routine-care-in-oncology-in-germany-real-world-survival-data
#8
JOURNAL ARTICLE
Norbert Marschner, Wolfgang Knauf
INTRODUCTION: Survival data reported by randomised controlled trials are collected in a highly selected patient population and can thus only be transferred to a limited extent to real-world patients: the patients in routine care are mostly older, present with more comorbidities and a worse general state of health. This so-called efficacy-effectiveness gap typically results in inferior survival data in routine healthcare. METHODS: Six prospective clinical tumour registries recruited a total of 11,679 patients receiving systemic therapy in haemato-oncological practices in Germany between 2006 and 2020...
March 15, 2024: Oncology Research and Treatment
https://read.qxmd.com/read/38480552/immunopet-ct-imaging-of-clear-cell-renal-cell-carcinoma-with-18-f-rccb6-a-first-in-human-study
#9
JOURNAL ARTICLE
Qianyun Wu, Yanfei Wu, You Zhang, Yihui Guan, Gang Huang, Fang Xie, Jianjun Liu, Wei Zhai, Weijun Wei
PURPOSE: The cluster of differentiation (CD70) is a potential biomarker of clear cell renal cell carcinoma (ccRCC). This study aims to develop CD70-targeted immuno-positron emission tomography/computed tomography (immunoPET/CT) imaging tracers and explore the diagnostic value in preclinical studies and the potential value in detecting metastases in ccRCC patients. METHODS: Four novel CD70-specific single-domain antibodies (sdAbs) were produced and labelled with 18 F by the aluminium fluoride restrained complexing agent (AlF-RESCA) method to develop radiotracers...
March 14, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38477383/percutaneous-microwave-ablation-of-t1a-renal-cell-carcinomas-a-10-year-single-center-retrospective-review
#10
JOURNAL ARTICLE
Cassie McCloskey, Angela Jacques, Dylan McCloskey, Jonathan Tibballs
INTRODUCTION: Partial nephrectomy is currently the preferred treatment option for T1a renal cell carcinomas (RCC), with nephron-sparing techniques, including microwave ablation, becoming more common in select patients. Primary aims are to document outcomes of microwave ablation for T1a RCCs in an Australian tertiary centre to add to the evidence for its safety and efficacy. METHODS: The prospectively maintained Sir Charles Gairdner Hospital Interventional Radiology database was retrospectively searched for all Renal Microwave ablations completed between June 2012 and February 2022...
March 13, 2024: Journal of Medical Imaging and Radiation Oncology
https://read.qxmd.com/read/38473355/cost-effectiveness-of-treatment-optimisation-with-biomarkers-for-immunotherapy-in-solid-tumours-a-systematic-review
#11
REVIEW
Sara Mucherino, Valentina Lorenzoni, Isotta Triulzi, Marzia Del Re, Valentina Orlando, Annalisa Capuano, Romano Danesi, Giuseppe Turchetti, Enrica Menditto
This study investigated the health economic evaluations of predictive biomarker testing in solid tumours treated with immune checkpoint inhibitors (ICIs). Searching PubMed, EMBASE, and Web of Science from June 2010 to February 2022, 58 relevant articles were reviewed out of the 730 screened. The focus was predominantly on non-small cell lung cancer (NSCLC) (65%) and other solid tumours (40%). Among the NSCLC studies, 21 out of 35 demonstrated cost-effectiveness, notably for pembrolizumab as first-line treatment when preceded by PD-L1 assessment, cost-effective at a threshold of $100,000/QALY compared to the standard of care...
February 29, 2024: Cancers
https://read.qxmd.com/read/38473038/cutting-edge-strategies-for-renal-tumour-like-lesions-in-granulomatosis-with-polyangiitis-a-systematic-review
#12
REVIEW
Luca Iorio, Marco Pizzi, Diego Cecchin, Federica Davanzo, Anna Ghirardello, Angelo Paolo Dei Tos, Andrea Doria, Roberto Padoan
BACKGROUND: Granulomatosis with polyangiitis (GPA) is characterised by granulomatous inflammation and small-to-medium vessel necrotising vasculitis, mainly affecting respiratory tract and kidneys. Renal involvement presenting as tumour-like lesions poses diagnostic and treatment challenges. METHODS: Following the observation of a GPA patient presenting with multiple renal tumour-like lesions, we conducted a systematic literature review on MEDLINE/PubMed, EMBASE, and Cochrane databases...
March 6, 2024: Diagnostics
https://read.qxmd.com/read/38471722/celastrol-ameliorates-lupus-by-promoting-apoptosis-of-autoimmune-t-cells-and-preventing-autoimmune-response-in-mrl-lpr-mice
#13
JOURNAL ARTICLE
Tianhong Xie, Hongliang Rui, Huiqiang Liu, Xin Liu, Xiang Liu, Ping Li
OBJECTIVE: Celastrol is a bioactive constituent extracted from Tripterygium wilfordii (thunder god vine). It has been demonstrated to have a therapeutic effect on experimental disease models for chronic inflammatory and immune disorders. In the present study, we investigated whether and how celastrol exerts a regulatory effect on the autoimmune response in MRL/lpr mice. METHODS: We performed an in vivo study to determine the therapeutic effects of celastrol in MRL/lpr mice and then further investigated the underlying mechanism of celastrol in the regulation of the autoimmune response in MRL/lpr mice...
March 11, 2024: Lupus Science & Medicine
https://read.qxmd.com/read/38465176/an-incidental-diagnosis-of-extraosseous-ewing-s-sarcoma-in-the-kidney
#14
Saleh Al-Gburi, Vinutha Thonse, Omer Abdalla, Manal Kumar
Ewing's sarcoma is generally observed in the skeletal and connective tissues of paediatric individuals. The occurrence of extraosseous neuroectodermal tumours is uncommon. Renal Ewing's sarcoma usually presents with flank pain, haematuria, or as an abdominal mass. Immunohistochemistry and fluorescence in situ hybridization (FISH) techniques are essential in its diagnosis and differentiation from other tumours. We present asymptomatic renal Ewing's sarcoma in a 19-year-old female patient who was diagnosed incidentally, and the CT scan confirmed a 2...
February 2024: Curēus
https://read.qxmd.com/read/38455502/familial-pulmonary-cysts-a-clue-to-diagnose-birt-hogg-dub%C3%A3-syndrome-a-case-report-and-literature-review
#15
Jinrui Miao, Qian Gao, Zilin Wang, Gang Hou
Birt-Hogg-Dubé syndrome (BHD) is an inherited autosomal dominant condition caused by germline mutations in the FLCN gene, mapped to chromosome 17p11.2. Typical manifestations include pulmonary cysts, spontaneous pneumothorax, fibrofolliculomas, and kidney neoplasms. This report details the case of a 56-year-old female non-smoker diagnosed with multiple pulmonary cysts, presenting with a history of recurrent spontaneous pneumothorax. A computed tomography (CT) scan of her daughter revealed similar pulmonary cysts, raising suspicion of BHD...
March 2024: Respirology Case Reports
https://read.qxmd.com/read/38452387/influence-of-different-intraoperative-fluid-management-on-postoperative-outcome-after-abdominal-tumours-resection
#16
JOURNAL ARTICLE
Matej Jenko, Katarina Mencin, Vesna Novak-Jankovic, Alenka Spindler-Vesel
BACKGROUND: Intraoperative fluid management is a crucial aspect of cancer surgery, including colorectal surgery and pancreatoduodenectomy. The study tests if intraoperative multimodal monitoring reduces postoperative morbidity and duration of hospitalisation in patients undergoing major abdominal surgery treated by the same anaesthetic protocols with epidural analgesia. PATIENTS AND METHODS: A prospective study was conducted in 2 parallel groups. High-risk surgical patients undergoing major abdominal surgery were randomly selected in the control group (CG), where standard monitoring was applied (44 patients), and the protocol group (PG), where cerebral oxygenation and extended hemodynamic monitoring were used with the protocol for intraoperative interventions (44 patients)...
March 7, 2024: Radiology and Oncology
https://read.qxmd.com/read/38445803/single-cell-transcriptomic-analysis-in-clear-cell-renal-cell-carcinoma-deciphering-the-role-of-app-within-the-tumour-microenvironment
#17
JOURNAL ARTICLE
Bo Guan, Ming Li, Di Cui, Chen Shen, Zongyao Hao, Xiaowei Li
Clear cell renal cell carcinoma (ccRCC) represents a significant challenge in oncology, primarily due to its resistance to conventional therapies. Understanding the tumour microenvironment (TME) is crucial for developing new treatment strategies. This study focuses on the role of amyloid precursor protein (APP) in tumour-associated macrophages (TAMs) within the ccRCC TME, exploring its potential as a prognostic biomarker. Basing TAM-related genes, the prognostic model was important to constructed. Employing advanced single-cell transcriptomic analysis, this research dissects the TME of ccRCC at an unprecedented cellular resolution...
March 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38434475/successful-treatment-of-a-case-of-crescentic-glomerulonephritis-in-a-patient-with-primary-peritoneal-carcinoma-a-case-report
#18
Aref Zribi, Amro Nagy, Marwa Al Riyami, Ikram A Burney
Crescentic glomerulonephritis has been associated with several solid tumour malignancies. Only a few cases of nephropathy have been reported in association with tubo-ovarian/peritoneal malignancies. We report a 55-year-old female patient who presented to a tertiary care centre, Muscat, Oman, in 2022. She developed combined immune complex-mediated glomerulonephritis and pauci-immune necrotising crescentic vasculitis simultaneously with the diagnosis of tubo-ovarian/peritoneal cancer. The baseline estimated glomerular filtration rate (eGFR) was 13 mL/min...
February 2024: Sultan Qaboos University Medical Journal
https://read.qxmd.com/read/38432069/igf-2-mediated-hypoglycemia-a-case-series-and-review-of-the-medical-therapies-for-refractory-hypoglycemia
#19
JOURNAL ARTICLE
Albert Vu, Constance Chik, Sarah Kwong
SUMMARY: Non-islet cell tumour hypoglycemia (NICTH), typically mediated by insulin-like growth factor 2 (IGF-2), is a rare but highly morbid paraneoplastic syndrome associated with tumours of mesenchymal or epithelial origin. Outside of dextrose administration and dietary modification which provide transient relief of hypoglycemia, resection of the underlying tumour is the only known cure for NICTH. Available medical therapies to manage hypoglycemia include glucocorticoids, recombinant growth hormone, and pasireotide...
January 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38427102/design-and-utilisation-of-a-novel-high-fidelity-low-cost-hybrid-tissue-simulation-model-to-facilitate-training-in-robot-assisted-partial-nephrectomy
#20
JOURNAL ARTICLE
Stefanie M Croghan, Miroslav Voborsky, Adam F Roche, Claire Condron, Dara A O'Keeffe, Barry B McGuire
Robot-assisted partial nephrectomy (RAPN) has rapidly evolved as the standard of care for appropriately selected renal tumours, offering key patient benefits over radical nephrectomy or open surgical approaches. Accordingly, RAPN is a key competency that urology trainees wishing to treat kidney cancer must master. Training in robotic surgery is subject to numerous challenges, and simulation has been established as valuable step in the robotic learning curve. However, simulation models are often both expensive and suboptimal in fidelity...
March 1, 2024: Journal of Robotic Surgery
keyword
keyword
6681
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.