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https://www.readbyqxmd.com/read/28414996/a-case-of-multiple-synchronous-quadruple-cancers-of-the-stomach-sigmoid-colon-rectum-and-pancreas
#1
Atsushi Nanashima, Tetsuro Tominaga, Takashi Nonaka, Kouki Wakata, Masaki Kunizaki, Shuichi Tobinaga, Yorihisa Sumida, Shigekazu Hidaka, Naoe Kinoshita, Terumitsu Sawai, Takeshi Nagayasu
INTRODUCTION: Multiple primary neoplasms are relatively rare, but their incidence has increased because of aging and improvements in diagnostic imaging. PRESENTATION OF CASE: A 67-year-old man presented with epigastric pain. On upper gastrointestinal endoscopy, an ulcer was seen at the gastric angle, and biopsy showed moderately differentiated adenocarcinoma (AC). Colonoscopy demonstrated a 15-mm lesion in the sigmoid colon and a submucosal lesion in the lower rectum...
April 2, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28391975/evaluation-of-endorectal-ultrasound-erus-and-mri-for-prediction-of-circumferential-resection-margin-crm-for-rectal-cancer
#2
Catherine Tsai, Cameron Hague, Wei Xiong, Manoj Raval, Ahmer Karimuddin, Carl Brown, P Terry Phang
ERUS and MRI are used for preoperative imaging of rectal cancer. Here, we compare ERUS and MRI for accuracy of CRM prediction at mid- and distal rectal locations. In retrospective review, 20 rectal cancer patients having TME surgery had both ERUS and MRI preoperatively: 8 mid rectum and 12 in distal rectum. Predicted CRM by ERUS and MRI were compared to TME pathology. Overall, predicted CRM was 6.5 ± 3.6 mm by ERUS, 7.7 ± 5.0 mm by MRI, and 6.0 ± 4.6 mm by pathology. Overall, correlation coefficients to pathology were 0...
March 27, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28372889/structure-based-deformable-image-registration-added-value-for-dose-accumulation-of-external-beam-radiotherapy-and-brachytherapy-in-cervical-cancer
#3
Laura E van Heerden, Antonetta C Houweling, Kees Koedooder, Zdenko van Kesteren, Niek van Wieringen, Coenraad R N Rasch, Bradley R Pieters, Arjan Bel
BACKGROUND AND PURPOSE: Structure-based deformable image registration (DIR) can be used to calculate accumulated brachytherapy (BT) and external-beam radiation therapy (EBRT) dose-volume histogram (DVH) parameters in cervical cancer. Since direct parameter addition does not take dose non-uniformity into account, the added value of DIR over addition methods was investigated for bladder and rectum. MATERIALS AND METHODS: For twelve patients (EBRT: 46Gy, EBRT+BT: D90 85-90GyEQD2 in equivalent dose in 2Gy fractions) the EBRT planning CT and BT planning MRI were registered using DIR...
March 31, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28291745/iterative-framework-for-the-joint-segmentation-and-ct-synthesis-of-mr-images-application-to-mri-only-radiotherapy-treatment-planning
#4
Ninon Burgos, Filipa Guerreiro, Jamie McClelland, Benoit Presles, Marc Modat, Simeon Nill, David Dearnaley, Nandita deSouza, Uwe Oelfke, Antje-Christin Knopf, Sebastien Ourselin, M Jorge Cardoso
To tackle the problem of MRI-only radiotherapy treatment planning (RTP), we propose a multi-atlas information propagation scheme that jointly segments organs and generates pseudo CT data from structural MR images. As the performance of the method strongly depends on the quality of the atlas database composed of multiple sets of aligned MR, CT and segmented images, we also propose a robust way of registering atlas MR and CT images, which combines structure-guided registration, and CT and MR image synthesis. We first evaluated the proposed framework in terms of segmentation and CT synthesis accuracy on 15 subjects with prostate cancer...
March 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28287399/a-novel-adaptive-needle-insertion-sequencing-for-robotic-single-needle-mr-guided-high-dose-rate-prostate-brachytherapy
#5
M Borot de Battisti, B Denis de Senneville, G Hautvast, D Binnekamp, J J W Lagendijk, M Maenhout, M A Moerland
MR-guided high-dose-rate (HDR) brachytherapy has gained increasing interest as a treatment for patients with localized prostate cancer because of the superior value of MRI for tumor and surrounding tissues localization. To enable needle insertion into the prostate with the patient in the MR bore, a single needle MR-compatible robotic system involving needle-by-needle dose delivery has been developed at our institution. Throughout the intervention, dose delivery may be impaired by: (1) sub-optimal needle positioning caused by e...
March 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28268867/fea-modeling-and-fluid-flow-simulation-of-human-rectum-with-inserted-bowel-catheters
#6
Yong Zhang, Tina VanRiper, Brian Rague, Drew Weidman
In this project, fluid flow and fluid-structure interaction are studied for the human lower gastrointestinal (GI) region. The study consists of two steps. First, we apply meshing methods to discretize both the human lower GI model and the catheter model at sufficient resolution suitable for importing into a Finite Element Analysis (FEA) tool. For model discretization, 3D models of the colon reconstructed from human MRI slices are used to obtain the valid inlet and outlet boundary surfaces. To resolve the viscous boundary layer in flow studies, a special structure of the near-wall volumetric mesh is built by triangular prisms that construct quasi-structured, multiple near-boundary sub-layers...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268809/automated-tracking-segmentation-and-trajectory-classification-of-pelvic-organs-on-dynamic-mri
#7
Iman Nekooeimehr, Susana Lai-Yuen, Paul Bao, Alfredo Weitzenfeld, Stuart Hart
Pelvic organ prolapse is a major health problem in women where pelvic floor organs (bladder, uterus, small bowel, and rectum) fall from their normal position and bulge into the vagina. Dynamic Magnetic Resonance Imaging (DMRI) is presently used to analyze the organs' movements from rest to maximum strain providing complementary support for diagnosis. However, there is currently no automated or quantitative approach to measure the movement of the pelvic organs and their correlation with the severity of prolapse...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227065/fea-modeling-and-fluid-flow-simulation-of-human-rectum-with-inserted-bowel-catheters
#8
Yong Zhang, Tina VanRiper, Brian Rague, Drew Weidman, Yong Zhang, Tina VanRiper, Brian Rague, Drew Weidman, Tina VanRiper, Drew Weidman, Brian Rague, Yong Zhang
In this project, fluid flow and fluid-structure interaction are studied for the human lower gastrointestinal (GI) region. The study consists of two steps. First, we apply meshing methods to discretize both the human lower GI model and the catheter model at sufficient resolution suitable for importing into a Finite Element Analysis (FEA) tool. For model discretization, 3D models of the colon reconstructed from human MRI slices are used to obtain the valid inlet and outlet boundary surfaces. To resolve the viscous boundary layer in flow studies, a special structure of the near-wall volumetric mesh is built by triangular prisms that construct quasi-structured, multiple near-boundary sub-layers...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227004/automated-tracking-segmentation-and-trajectory-classification-of-pelvic-organs-on-dynamic-mri
#9
Iman Nekooeimehr, Susana Lai-Yuen, Paul Bao, Alfredo Weitzenfeld, Stuart Hart, Iman Nekooeimehr, Susana Lai-Yuen, Paul Bao, Alfredo Weitzenfeld, Stuart Hart, Paul Bao, Susana Lai-Yuen, Stuart Hart, Alfredo Weitzenfeld, Iman Nekooeimehr
Pelvic organ prolapse is a major health problem in women where pelvic floor organs (bladder, uterus, small bowel, and rectum) fall from their normal position and bulge into the vagina. Dynamic Magnetic Resonance Imaging (DMRI) is presently used to analyze the organs' movements from rest to maximum strain providing complementary support for diagnosis. However, there is currently no automated or quantitative approach to measure the movement of the pelvic organs and their correlation with the severity of prolapse...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28133240/-a-case-of-primary-peritoneal-cancer-successfully-treated-with-debulking-surgery-and-postoperative-chemotherapy
#10
Koki Maeda, Masami Tabata, Taiki Moriyama, Tatsuya Sakamoto, Yu Fujimura, Ichiro Ohsawa, Kenji Kato, Makoto Iwata, Takayuki Sanda
A 52-year-old woman with abdominal pain and a feeling of incomplete evacuation visited a local clinic. Enlargement of the right ovary was detected, and the patient was referred to the gynecological department of our hospital. CT and MRI revealed a round-shaped mass, 8 cm in diameter, with cystic and solid components in the Douglas pouch. The patient underwent a laparotomy under the diagnosis of ovarian cancer. Intraoperatively, both the ovaries appeared normal and the tumor strongly adhered to the rectum and uterus...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28116474/prenatal-magnetic-resonance-and-ultrasonographic-findings-in-small-bowel-obstruction-imaging-clues-and-postnatal-outcomes
#11
Eva I Rubio, Anna R Blask, Andrea T Badillo, Dorothy I Bulas
BACKGROUND: Prenatal small-bowel obstruction can result from single or multiple atresias, and it can be an isolated abnormality or part of a syndrome. It is sometimes the first manifestation of cystic fibrosis. Accurate prediction of the level of obstruction and length of bowel affected can be difficult, presenting a challenge for counseling families and planning perinatal management. OBJECTIVE: To review the prenatal US and MRI findings of small-bowel obstruction and to assess whether fetal MRI adds information that could improve prenatal counseling and perinatal management...
January 23, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28089690/mri-evaluation-of-rectal-cancer-staging-and-restaging
#12
REVIEW
Courtney C Moreno, Patrick S Sullivan, Pardeep K Mittal
Magnetic resonance imaging (MRI) plays an important role in the staging and restaging of rectal cancer. Multiplanar high-resolution (≤3-mm section thickness) T2-weighted images are the primary sequences used for rectal cancer staging. No preprocedural bowel cleansing regimen, intravenous contrast material, nor endorectal coil is necessary. MRI is highly accurate for differentiating T1-T2 disease from T3 and T4 disease, an important distinction as patients with T3 and T4 tumors typically undergo preoperative neoadjuvant chemoradiation before resection...
May 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28071947/presacral-abscess-as-a-rare-complication-of-sacral-nerve-stimulator-implantation
#13
A Gumber, S Ayyar, H Varia, S Pettit
A 50-year-old man with intractable anal pain attributed to proctalgia fugax underwent insertion of a sacral nerve stimulator via the right S3 vertebral foramen for pain control with good symptomatic relief. Thirteen months later, he presented with signs of sepsis. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a large presacral abscess. MRI demonstrated increased enhancement along the pathway of the stimulator electrode, indicating that the abscess was caused by infection introduced at the time of sacral nerve stimulator placement...
March 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28065369/the-stratification-of-severity-of-acute-radiation-proctopathy-after-radiotherapy-for-cervical-carcinoma-using-diffusion-weighted-mri
#14
Xiang Sheng Li, Hong Fang, Yunlong Song, Dechang Li, Yingjie Wang, Hongxian Zhu, Limin Meng, Ping Wang, Dong Wang, Hongxia Fan
OBJECTIVE: To determine whether diffusion-weighted imaging (DWI) can be used for quantitatively evaluating severity of acute radiation proctopathy after radiotherapy for cervical carcinoma. MATERIALS AND METHODS: One hundred and twenty-four patients with cervical carcinoma underwent MR examination including DWI before and after radiotherapy. Acute radiation proctopathy was classified into three groups (grade 0, grade I-II and grade III-IV) according to Toxicity Criteria of the Radiation Therapy Oncology Group (RTOG)...
February 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28048869/su-f-j-145-mri-guided-interventional-boost-radiotherapy-for-rectal-cancer-investigating-the-feasibility-of-adapting-the-anatomy
#15
J J E Kleijnen, A M Couwenberg, B van Asselen, J J W Lagendijk, M Intven, B W Raaymakers
PURPOSE: The recent development of an MRI-linac allows adaptation of treatments to the anatomy of the moment. This anatomy, in turn, could be altered into a more favorable situation for radiotherapy purposes. The purpose of this study is to investigate the potential dosimetric benefits of manipulating rectal anatomy in MRI-guided interventional external-beam radiotherapy for rectal cancer. METHODS: For this retrospective analysis, four patients (1M/3F) diagnosed with rectal cancer were included...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048067/su-f-t-36-dosimetric-comparison-of-point-based-vs-target-based-prescription-for-intracavitary-brachytherapy-in-cancer-of-the-cervix
#16
M Ashenafi, D McDonald, J Peng, C Mart, N Koch, L Cooper, K Vanek
PURPOSE: Improved patient imaging used for planning the treatment of cervical cancer with Tandem and Ovoid (T&O) Intracavitary high-dose-rate brachytherapy (HDR) now allows for 3D delineation of target volumes and organs-at-risk. However, historical data relies on the conventional point A-based planning technique. A comparative dosimetric study was performed by generating both target-based (TBP) and point-based (PBP) plans for ten clinical patients. METHODS: Treatment plans created using Elekta Oncentra v...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047948/su-f-t-203-high-dose-definitive-proton-therapy-with-integrated-boost-to-hypoxic-subvolumes-determined-by-18f-fluoromisonidazole-fmiso-pet-ct-for-patients-with-recurrent-chordomas-using-intensity-modulated-proton-therapy-impt
#17
S Yan, G Broussard, K De, Amorim Bernstein, Y Wang
PURPOSE: Recurrent chordomas are difficult to control locally. This dosimetric study investigates the feasibility of dose escalation to hypoxic regions, visualized on FMISO-PET, while respecting the dose constraints to the neighboring normal tissues/organs. We propose to deliver a higher dose to the areas of hypoxia (84.5Gy) using IMPT with the goal of improving local control. METHODS: We currently have four patients with hypoxic subvolumes (HSV) greater than 10cc from the FMISO-PET image...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047374/su-f-t-55-reproducibility-of-interstitial-hdr-brachytherapy-plans
#18
S Lee, R Ellis, B Traughber, T Podder
PURPOSE: Treating gynecological cancers with interstitial high-dose-rate (HDR) brachytherapy requires precise reconstruction of catheter positions to obtain accurate dosimetric plans. In this study, we investigated the degree of reproducibility of dosimetric plans for Syed HDR brachytherapy. METHODS: We randomly selected five patients having cervix-vaginal cancer who were recently treated in our clinic with interstitial HDR brachytherapy with a prescription dose of 25-30 Gy in five fractions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046477/we-de-201-03-combined-use-of-192ir-60co-and-169yb-sources-with-the-novel-direction-modulated-brachytherapy-tandem-applicator-for-high-dose-rate-brachytherapy-planning-of-cervical-cancer
#19
H Safigholi, D Han, S Mashouf, A Soliman, A S Meigooni, A Owrangi, W Y Song
PURPOSE: To evaluate the improvement in plan quality when various combinations of 192Ir, 60Co, and 169Yb sources are used in combination with a novel direction modulated brachytherapy (DMBT) tandem applicator for high dose rate brachytherapy of cervical cancer. METHODS: The proposed DMBT tandem applicator is designed for image-guided adaptive brachytherapy (IGABT), especially MRI, of cervical cancer. It has 6 peripheral holes of 1.3-mm width, grooved along a 5.4-mm diameter nonmagnetic tungsten alloy rod of density 18...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27992058/an-mri-compatible-patient-rotation-system-design-construction-and-first-organ-deformation-results
#20
Brendan Whelan, Gary P Liney, Jason A Dowling, Robba Rai, Lois Holloway, Leigh McGarvie, Ilana Feain, Michael Barton, Megan Berry, Rob Wilkins, Paul Keall
PURPOSE: Conventionally in radiotherapy, a very heavy beam forming apparatus (gantry) is rotated around a patient. From a mechanical perspective, a more elegant approach is to rotate the patient within a stationary beam. Key obstacles to this approach are patient tolerance and anatomical deformation. Very little information on either aspect is available in the literature. The purpose of this work was therefore to design and test an MRI-compatible patient rotation system such that the feasibility of a patient rotation workflow could be tested...
February 2017: Medical Physics
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