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https://www.readbyqxmd.com/read/29127435/intensified-preoperative-chemoradiation-by-adding-oxaliplatin-in-locally-advanced-primary-operable-ct3nxm0-rectal-cancer-impact-on-long-term-outcome-results-of-the-phase%C3%A2-ii-tako-05-abcsg-r%C3%A2-02-trial
#1
P Kogler, A F DeVries, W Eisterer, J Thaler, L Sölkner, D Öfner
PURPOSE: The major goals of preoperative treatment for locally advanced rectal cancers (LARCs) are improvement of local tumor control, tumor downsizing, and downstaging. Modifications with respect to standardized chemoradiation protocol, e. g., integrating oxaliplatin, are realized with the aim of improving primary tumor response and patient outcome. PATIENTS AND METHODS: In this phase II multicenter study, patients with LARC of the mid- or lower rectum, cT3cNxcM0 as staged by MRI, were included and treated preoperatively with a combination of capecitabine and oxaliplatin following a standardized protocol during radiation...
November 10, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29102740/clinical-outcomes-with-mri-guided-image-based-brachytherapy-in-cervical-cancer-an-institutional-experience
#2
Vijai Simha, Bhavana Rai, Firuza D Patel, Rakesh Kapoor, Suresh C Sharma, Oinam A Singh, Veenu Singla, Bhaswanth Dhanireddy, Sushmita Ghoshal
PURPOSE: To evaluate the long-term disease control and toxicity to the organs at risk after dose-escalated image-based adaptive brachytherapy (BT) in cervical cancer. METHODS AND MATERIALS: Sixty patients of cervical cancer were treated with external radiotherapy 46 Gy in 23 fractions with weekly cisplatin and MRI-guided BT 7 Gy × 4 fractions with a minimum dose of 85.7 Gy (EQD2) to the high-risk clinical target volume (HRCTV). The BT dose was initially prescribed to point A and plans were optimized to ensure coverage of both point A and HRCTV while maintaining doses to the organs at risk within the recommended constraints...
November 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29101415/target-tailoring-and-proton-beam-therapy-to-reduce-small-bowel-dose-in-cervical-cancer-radiotherapy-a-comparison-of-benefits
#3
Peter de Boer, Agustinus J A J van de Schoot, Henrike Westerveld, Mark Smit, Marrije R Buist, Arjan Bel, Coen R N Rasch, Lukas J A Stalpers
PURPOSE: The aim of the study was to investigate the potential clinical benefit from both target tailoring by excluding the tumour-free proximal part of the uterus during image-guided adaptive radiotherapy (IGART) and improved dose conformity based on intensity-modulated proton therapy (IMPT). METHODS: The study included planning CTs from 11 previously treated patients with cervical cancer with a >4-cm tumour-free part of the proximal uterus on diagnostic magnetic resonance imaging (MRI)...
November 3, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29100742/outcome-of-neoadjuvant-chemoradiation-in-mri-staged-locally-advanced-rectal-cancer-retrospective-analysis-of-123-chinese-patients
#4
Shing Fung Lee, Chi Leung Chiang, Francis Ann Shing Lee, Yiu Wah Wong, Chi Ming Poon, Frank Chi Sing Wong, Stewart Yuk Tung
BACKGROUND: For advanced rectal cancer with involved or threatened mesorectal fascia (MRF), current standard is pre-operative long course chemoradiotherapy (PLCRT) with either capecitabine or 5-fluorouracil (5-FU). However, few Chinese data on its clinical outcome are available, especially for those with pelvic MRI staging. METHODS: Between Jan-2009 and Oct-2014, 123 consecutive patients with biopsy proven adenocarcinoma of rectum, all with pelvic MRI staging, selected for PLCRT after multi-disciplinary team discussion were recruited...
November 1, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29094417/defining-probabilities-of-bowel-resection-in-deep-endometriosis-of-the-rectum-prediction-with-preoperative-magnetic-resonance-imaging
#5
Alessio Perandini, Simone Perandini, Stefania Montemezzi, Cecilia Bonin, Gaia Bellini, Valentino Bergamini
AIM: Deep endometriosis of the rectum is a highly challenging disease, and a surgical approach is often needed to restore anatomy and function. Two kinds of surgeries may be performed: radical with segmental bowel resection or conservative without resection. Most patients undergo magnetic resonance imaging (MRI) before surgery, but there is currently no method to predict if conservative surgery is feasible or whether bowel resection is required. The aim of this study was to create an algorithm that could predict bowel resection using MRI images, that was easy to apply and could be useful in a clinical setting, in order to adequately discuss informed consent with the patient and plan the an appropriate and efficient surgical session...
November 2, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29089277/early-outcomes-and-impact-of-a-hybrid-ic-is-applicator-for-a-new-mri-based-cervical-brachytherapy-program
#6
Matthew M Harkenrider, Murat Surucu, Grant Harmon, Michael L Mysz, Steven M Shea, Joseph Yacoub, Ari Goldberg, Margaret Liotta, Abigail Winder, Ronald Potkul, John C Roeske, William Small
PURPOSE: The purpose of this study was to report early outcomes and assess the learning curve in a new MRI-based cervical brachytherapy program. METHODS: We accrued 33 patients prospectively, and only patients with ≥3 months' followup (n = 27) were assessed for disease control and toxicity. Eras were defined as first half and second half for the intracavitary (IC)-only era (n = 13 each), and the intracavitary/interstitial (IC/IS) era was separated by difference in applicator availability (n = 7)...
October 28, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29039108/preliminary-results-of-a-new-workflow-for-mri-ct-based-image-guided-brachytherapy-in-cervical-carcinoma
#7
Miho Watanabe Nemoto, Yuma Iwai, Gentaro Togasaki, Marie Kurokawa, Rintarou Harada, Hiroki Kobayashi, Takashi Uno
PURPOSE: We propose a method of image-guided brachytherapy (IGBT) that combines MRI-based target volume delineation for the first fraction with CT datasets of subsequent fractions, using an automatic, applicator-based co-registration, and report our preliminary experience. MATERIALS AND METHODS: The MRI of the first fraction was used for the first brachytherapy planning. For each subsequent brachytherapy fraction, after the same applicator insertion, a new CT scan with the applicator in place was obtained...
October 16, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28993108/evaluation-of-interfractional-variation-of-organs-and-displacement-of-catheters-during-high-dose-rate-interstitial-brachytherapy-for-gynecologic-malignancies
#8
Soyoung Lee, Ellis Rodney, Bryan Traughber, Tithi Biswas, Valdir Colussi, Tarun Podder
PURPOSE: To investigate the dosimetric effects due to interfractional changes in catheter position and variation in patient's anatomy during the course of interstitial high-dose-rate (HDR) brachytherapy. METHODS AND MATERIALS: A total of 15 patients with either cervical or vaginal cancer underwent interstitial HDR brachytherapy. Interstitial catheters and fiducials were placed under fluoroscopy and intraoperative 3T MRI to confirm the desired catheter placement for adequate target volume coverage...
October 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28991083/prediction-of-n0-irradiated-rectal-cancer-comparing-mri-before-and-after-preoperative-chemoradiotherapy
#9
COMPARATIVE STUDY
Fabio Pomerri, Filippo Crimì, Nicola Veronese, Alessandro Perin, Carmelo Lacognata, Francesca Bergamo, Caterina Boso, Isacco Maretto
BACKGROUND: The prediction of lymph node status using MRI has an impact on the management of rectal cancer, both before and after preoperative chemoradiotherapy. OBJECTIVE: The purpose of this study was to maximize the negative predictive value and sensitivity of mesorectal lymph node imaging after chemoradiotherapy because postchemoradiation node-negative patients may be treated with rectum-sparing approaches. DESIGN: This was a retrospective study...
November 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28951749/evaluation-of-intraoperative-magnetic-resonance-imaging-ultrasound-fusion-optimization-for-low-dose-rate-prostate-brachytherapy
#10
Stephen Abel, Paul Renz, Olivier Gayou, Jie Tang, E Day Werts, Mark Trombetta
PURPOSE: Intraoperative planning with transrectal ultrasound (US) is used for accurate seed placement and optimal dosimetry in prostate brachytherapy. However, prostate magnetic resonance imaging (MRI) has shown superiority in delineation of prostate anatomy. Accordingly, MRI/US fusion may be useful for accurate intraoperative planning. We analyzed planning with MRI/US fusion to compare differences in dosimetry and volume to that derived from the postoperative computed tomography (CT)...
August 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28940520/direction-modulated-brachytherapy-dmbt-for-treatment-of-cervical-cancer-a-planning-study-with-192ir-60co-and-169yb-hdr-sources
#11
Habib Safigholi, Dae Yup Han, Shahram Mashouf, Abraam Soliman, Ali S Meigooni, Amir Owrangi, William Y Song
PURPOSE: To evaluate plan quality of a novel MRI-compatible direction modulated brachytherapy (DMBT) tandem applicator using 192Ir, 60Co, and 169Yb HDR brachytherapy sources, for various cervical cancer high-risk clinical target volumes (CTVHR ). MATERIALS AND METHODS: The novel DMBT tandem applicator has six peripheral grooves of 1.3-mm diameter along a 5.4-mm thick nonmagnetic tungsten alloy rod. Monte Carlo (MC) simulations were used to benchmark the dosimetric parameters of the 192Ir, 60Co, and 169Yb HDR sources in a water phantom against the literature data...
September 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/28931946/comparison-of-perfusion-models-for-quantitative-t1-weighted-dce-mri-of-rectal-cancer
#12
Tanja Gaa, Wiebke Neumann, Sonja Sudarski, Ulrike I Attenberger, Stefan O Schönberg, Lothar R Schad, Frank G Zöllner
In this work, the two compartment exchange model and two compartment uptake model were applied to obtain quantitative perfusion parameters in rectum carcinoma and the results were compared to those obtained by the deconvolution algorithm. Eighteen patients with newly diagnosed rectal carcinoma underwent 3 T MRI of the pelvis including a T1 weighted dynamic contrastenhanced (DCE) protocol before treatment. Mean values for Plasma Flow (PF), Plasma Volume (PV) and Mean Transit Time (MTT) were obtained for all three approaches and visualized in parameter cards...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28921932/fetal-mri-compared-with-ultrasound-for-the-diagnosis-of-obstructive-genital-malformations
#13
Anne Elodie Millischer, David Grevent, Véronique Rousseau, Neil O'Gorman, Pascale Sonigo, Bettina Bessieres, Yves Ville, Nathalie Boddaert, Laurent J Salomon
OBJECTIVE: To compare the accuracy of magnetic resonance imaging (MRI) and ultrasound (US) to diagnose and characterize congenital obstructive genital abnormalities. METHOD: Retrospective cohort of 20 fetuses who underwent a fetal MRI following a US diagnosis of obstructive urogenital malformation. We compared MRI and US findings and their correlation with the definitive diagnosis. RESULT: The correct diagnosis was obtained in 6/20 (30%) cases and 19/20 cases (95%) with US and MRI, respectively...
September 16, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28863161/diffusion-weighted-imaging-in-patients-with-rectal-cancer-comparison-between-gaussian-and-non-gaussian-models
#14
COMPARATIVE STUDY
Georgios C Manikis, Kostas Marias, Doenja M J Lambregts, Katerina Nikiforaki, Miriam M van Heeswijk, Frans C H Bakers, Regina G H Beets-Tan, Nikolaos Papanikolaou
PURPOSE: The purpose of this study was to compare the performance of four diffusion models, including mono and bi-exponential both Gaussian and non-Gaussian models, in diffusion weighted imaging of rectal cancer. MATERIAL AND METHODS: Nineteen patients with rectal adenocarcinoma underwent MRI examination of the rectum before chemoradiation therapy including a 7 b-value diffusion sequence (0, 25, 50, 100, 500, 1000 and 2000 s/mm2) at a 1.5T scanner. Four different diffusion models including mono- and bi-exponential Gaussian (MG and BG) and non-Gaussian (MNG and BNG) were applied on whole tumor volumes of interest...
2017: PloS One
https://www.readbyqxmd.com/read/28846947/transanal-total-mesorectal-excision-as-a-surgical-procedure-for-diffuse-cavernous-hemangioma-of-the-rectum-a-case-report
#15
Xian-Rui Wu, Wei-Wen Liang, Xing-Wei Zhang, Liang Kang, Ping Lan
BACKGROUND: The safety and feasibility of transanal total mesorectal excision (TaTME) were demonstrated in the management of rectal cancer. However, its role in the management of patients with diffuse cavernous hemangioma of the rectum (DCHR) has not been evaluated. METHODS: A female patient with DCHR was admitted to our hospital. Colonoscopy, magnetic resonance imaging (MRI), abdominal computed tomography (CT) and arteriography were performed. Lesions were detected in mesorectum and rectal wall extending from the dentate line to 5cm proximally...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28836241/-standardized-development-of-transanal-endoscopic-microsurgery
#16
Guole Lin
Transanal endoscopic microsurgery (TEM) is currently the only one-port system in endoscopic surgery, which a direct endoluminal approach can lead to the target organ through a natural opening of human body. TEM has been applied in colorectal surgery for over 3 decades. Compared with radical surgery, TEM has the advantages, such as quicker recovery, shorter hospital stay and fewer complications. One perfect TEM surgical system, which mainly consists of three parts, namely peculiar rectoscope for surgery, special surgical instruments and imaging system, is the foundation of standardized development of TEM...
August 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28803449/prospective-comparison-between-magnetic-resonance-imaging-and-computed-tomography-in-colorectal-cancer-staging
#17
Frederick H X Koh, Ker-Kan Tan, Lynette L S Teo, Bertrand W L Ang, Yee-Liang Thian
BACKGROUND: Diffusion-weighted (DW) imaging is a functional magnetic resonance imaging (MRI) technique that detects lesions with high cellularity, such as malignant tumours. This prospective study was performed to compare the accuracy of DW-MRI with multidetector computed tomography (MDCT) in staging of colorectal cancer. METHODS: Thirty patients with histologically proven colorectal cancer were prospectively recruited. Each patient underwent both MDCT and DW-MRI of the abdomen-pelvis for primary staging...
August 13, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28802956/magnetic-resonance-imaging-compared-with-rectal-endoscopic-sonography-for-the-prediction-of-infiltration-depth-in-colorectal-endometriosis
#18
Arane Kim, Pedro Fernandez, Brigitte Martin, Laurent Palazzo, Lara Ribeiro-Parenti, Francine Walker, Margot Bucau, Helene Collinot, Dominique Luton, Martin Koskas
STUDY OBJECTIVE: To compare the accuracies of magnetic resonance imaging (MRI) and rectal endoscopic sonography (RES) in the prediction of the infiltration depth of colorectal endometriosis. DESIGN: A retrospective cohort study (Canadian Task Force classification II-2). SETTING: A university teaching hospital. PATIENTS: Forty patients with symptomatic deep infiltrating endometriosis (DIE) of the rectum who underwent colorectal resection were included...
November 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28762189/prediction-of-lateral-pelvic-lymph-node-metastasis-from-lower-rectal-cancer-using-magnetic-resonance-imaging-and-risk-factors-for-metastasis-multicenter-study-of-the-lymph-node-committee-of-the-japanese-society-for-cancer-of-the-colon-and-rectum
#19
Shimpei Ogawa, Jin-Ichi Hida, Hideyuki Ike, Tetsushi Kinugasa, Mitsuyoshi Ota, Eiji Shinto, Michio Itabashi, Takahiro Okamoto, Masakazu Yamamoto, Kenichi Sugihara, Toshiaki Watanabe
PURPOSE: The goal of the study was to examine prediction of lateral pelvic lymph node (LPLN) metastasis from lower rectal cancer using a logistic model including risk factors for LPLN metastasis and magnetic resonance imaging (MRI) clinical LPLN (cLPLN) status, compared to prediction based on MRI alone. METHODS: The subjects were 272 patients with lower rectal cancer who underwent MRI prior to mesorectal excision combined with LPLN dissection (LPLD) at six institutes...
October 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28757404/intermediate-dose-volume-parameters-and-the-development-of-late-rectal-toxicity-after-mri-guided-brachytherapy-for-locally-advanced-cervix-cancer
#20
Reem Ujaimi, Michael Milosevic, Anthony Fyles, Akbar Beiki-Ardakani, Marco Carlone, Haiyan Jiang, Patricia Lindsay, Jason Xie, Rachel Gerber, Jennifer Croke, Julia Skliarenko, Wilfred Levin, Kathy Han
PURPOSE: The dose delivered to the most exposed 2 cm(3) [Formula: see text] of the rectum and bladder is predictive of late rectal and bladder toxicity in cervix cancer patients. We investigated the predictive value of intermediate doses to the rectum and bladder for late rectal/bladder toxicity after MRI-guided brachytherapy for patients with locally advanced cervix cancer. METHODS AND MATERIALS: Toxicity was prospectively graded using Common Toxicity Criteria for Adverse Events v4...
July 27, 2017: Brachytherapy
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