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https://www.readbyqxmd.com/read/29331573/deformable-image-registration-based-contour-propagation-yields-clinically-acceptable-plans-for-mri-based-cervical-cancer-brachytherapy-planning
#1
Christina Hunter Chapman, Daniel Polan, Karen Vineberg, Shruti Jolly, Katherine E Maturen, Kristy K Brock, Joann I Prisciandaro
PURPOSE: To study the dosimetric impact of deformable image registration-based contour propagation on MRI-based cervical cancer brachytherapy planning. METHODS AND MATERIALS: High-risk clinical target volume (HRCTV) and organ-at-risk (OAR) contours were delineated on MR images of 10 patients who underwent ring and tandem brachytherapy. A second set of contours were propagated using a commercially available deformable registration algorithm. "Manual-contour" and "propagated-contour" plans were optimized to achieve a maximum dose to the most minimally exposed 90% of the volume (D90) (%) of 6 Gy/fraction, respecting minimum dose to the most exposed 2cc of the volume (D2cc) OAR constraints of 5...
January 10, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29328961/vaginal-delivery-related-changes-in-the-pelvic-organ-position-and-vaginal-cross-sectional-area-in-the-general-population
#2
Shotaro Naganawa, Eriko Maeda, Akifumi Hagiwara, Shiori Amemiya, Wataru Gonoi, Shouhei Hanaoka, Takeharu Yoshikawa, Kuni Ohtomo
PURPOSE: Evaluate the effect of vaginal delivery on pelvic organ positions and vaginal cross-sectional areas. METHODS: MRI of 119 premenopausal women were grouped according to the number of deliveries. The distances from the three 3-reference points (bladder, uterus, and rectum) to two 2-lines (pubococcygeal-line (PCL) and midpubic-line (MPL)), length of H- and M-lines and vaginal cross-sectional area were compared between the groups. RESULTS: With increasing parity, distance from the rectum to PCL tended to increase (nullipara vs...
December 15, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29300184/correlations-between-contouring-similarity-metrics-and-simulated-treatment-outcome-for-prostate-radiotherapy
#3
Dale Roach, Michael G Jameson, Jason A Dowling, Martin Andrew Ebert, Peter B Greer, Angel M Kennedy, Sandie Watt, Lois C Holloway
Many similarity metrics exist for inter-observer contouring variation studies, however no correlation between metric choice and prostate cancer radiotherapy dosimetry has been explored. These correlations were investigated in this study. Two separate trials were undertaken, the first a thirty-five patient cohort with three observers, the second a five patient dataset with ten observers. Clinical and planning target volumes (CTV and PTV), rectum, and bladder were independently contoured by all observers in each trial...
January 4, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29288190/can-we-save-the-rectum-by-watchful-waiting-or-transanal-microsurgery-following-chemo-radiotherapy-versus-total-mesorectal-excision-for-early-rectal-cancer-star-trec-study-protocol-for-a-multicentre-randomised-feasibility-study
#4
Anouk J M Rombouts, Issam Al-Najami, Natalie L Abbott, Ane Appelt, Gunnar Baatrup, Simon Bach, Aneel Bhangu, Karen-Lise Garm Spindler, Richard Gray, Kelly Handley, Manjinder Kaur, Ellen Kerkhof, Camilla Jensenius Kronborg, Laura Magill, Corrie A M Marijnen, Iris D Nagtegaal, Lars Nyvang, Femke P Peters, Per Pfeiffer, Cornelis Punt, Philip Quirke, David Sebag-Montefiore, Mark Teo, Nick West, Johannes H W de Wilt
INTRODUCTION: Total mesorectal excision (TME) is the highly effective standard treatment for rectal cancer but is associated with significant morbidity and may be overtreatment for low-risk cancers. This study is designed to determine the feasibility of international recruitment in a study comparing organ-saving approaches versus standard TME surgery. METHODS AND ANALYSIS: STAR-TREC trial is a multicentre international randomised, three-arm parallel, phase II feasibility study in patients with biopsy-proven adenocarcinoma of the rectum...
December 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/29280466/image-distortions-on-a-plastic-interstitial-computed-tomography-magnetic-resonance-brachytherapy-applicator-at-3%C3%A2-tesla-magnetic-resonance-imaging-and-their-dosimetric-impact
#5
Laura E van Heerden, Zdenko van Kesteren, Oliver J Gurney-Champion, Antonetta C Houweling, Kees Koedooder, Coen R N Rasch, Bradley R Pieters, Arjan Bel
PURPOSE: To quantify magnetic resonance imaging (MRI) distortions on a plastic intracavitary/interstitial applicator with plastic needles at a field strength of 3 T and to determine the dosimetric impact, using patient data. METHODS AND MATERIALS: For 11 cervical cancer patients, our clinical MRI protocol was extended with 3 scans. From the first scan, a multi-echo acquisition, a map of the magnetic field (B0) was calculated and used to quantify the field inhomogeneity...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29280456/magnetic-resonance-image-guided-adaptive-brachytherapy-in-locally-advanced-cervical-cancer-an-experience-from-a-tertiary-cancer-center-in-a-low-and-middle-income-countries-setting
#6
Umesh Mahantshetty, Rahul Krishnatry, Vinod Hande, Swamidas Jamema, Yogesh Ghadi, Reena Engineer, Supriya Chopra, Lavanya Gurram, Deepak Deshpande, Shyamkishore Shrviastava
PURPOSE: To determine the clinical impact of magnetic resonance image guided adaptive brachytherapy (IGABT) for locally advanced cervical cancer (LACC) (stages II and III) in a tertiary care cancer hospital in a low and middle income countries setting. METHODS AND MATERIALS: Ninety-four LACC patients enrolled in a prospective EMBRACE (An International Study on MRI-Guided Brachytherapy in Locally Advanced Cervical Cancer) protocol treated with external radiation therapy (45 Gy in 25 fractions) with or without weekly cisplatin, followed by magnetic resonance IGABT (4 fractions of 7 Gy), were analyzed in detail for dosimetric and clinical outcomes including late toxicities...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29262507/-measurement-reproducibility-of-parameters-derived-from-introvoxel-incoherent-motion-diffusion-weighted-mri-imaging-of-rectal-cancer
#7
Y K Meng, C D Zhang, H M Zhang, F Ye, H Ouyang, X M Zhao, K Xu, C W Zhou
Objective: To study the measurement reproducibility of parameters derived from introvoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI)-MRI of rectal cancer between- and within- radiologists. Methods: Clinical data of 34 patients with rectal cancer were prospective analyzed. Conventional MRI sequences, IVIM DWI-MRI with sixteen b values and dynamic contrast enhancement (DCE)-MRI sequences of rectum were acquired by GE 3.0-T MRI imager. The IVIM sequence images with b value=1000 sec/mm(2) were selected to measure the maximum axial section of tumor by a radiologist with 15 year-experiences in gastrointestinal cancer imaging...
December 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29241706/placement-of-an-absorbable-rectal-hydrogel-spacer-in-patients-undergoing-low-dose-rate-brachytherapy-with-palladium-103
#8
Amandeep S Taggar, Tomer Charas, Gil'ad N Cohen, Keeratikarn Boonyawan, Marisa Kollmeier, Sean McBride, Nitin Mathur, Antonio L Damato, Michael J Zelefsky
PURPOSE: Rates of rectal toxicity after low-dose-rate (LDR) brachytherapy for prostate cancer are dependent on rectal dose, which is associated with rectal distance from prostate and implanted seeds. Placement of a hydrogel spacer between the prostate and rectum has proven to reduce the volume of the rectum exposed to higher radiation dose levels in the setting of external beam radiotherapy. We present our findings with placing a rectal hydrogel spacer in patients following LDR brachytherapy, and we further assess the impact of this placement on dosimetry and acute rectal toxicity...
December 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29241705/characterizing-the-impact-of-adaptive-planning-on-image-guided-perineal-interstitial-brachytherapy-for-gynecologic-malignancies
#9
Adam Gladwish, Ananth Ravi, Lisa Barbera, Lucas Mendez, Melanie Davidson, Laura D'Alimonte, David D'Souza, Matt Wronski, Eric Leung
PURPOSE: To determine the dosimetric impact of organ and implant motion/deformation in the context of adaptive planning in image-guided gynecologic brachytherapy using a 3-fraction transperineal approach. METHODS AND MATERIALS: Twenty-six patients were analyzed. Each patient was treated with three fractions given over a 24-h period using a single insertion. A planning CT scan (±MRI) was acquired before the first fraction. A verification scan was taken within 1 h following the second fraction...
December 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29230498/trans-rectal-ultrasound-guided-autologous-blood-injection-in-the-interprostatorectal-space-prior-to-percutaneous-mri-guided-cryoablation-of-the-prostate
#10
Julien Garnon, Roberto Luigi Cazzato, Guillaume Koch, Ishaq Fahmi Uri, Georgia Tsoumakidou, Jean Caudrelier, Thibault Tricard, Afshin Gangi, Hervé Lang
OBJECTIVE: To report a novel technique of ultrasound-guided injection of autologous blood in the interprostatorectal space, in an attempt to facilitate ablative prostatic procedures by widening durably the space between the rectum and the prostate. MATERIALS AND METHODS: Between April and November 2016, four consecutive patients underwent the haemoprotection injection technique. For each patient, we recorded the time to perform the technique, the amount of injected blood, the achieved distances between the rectum and the prostate post-injection at fixed defined points (apex, middle, and base of prostate at the midline, left, and right sides of the gland), the extension of the ice ball outside the prostate capsule at those fixed points, and whether any residual blood was present on 1-month follow-up MRI...
December 11, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29204165/throwing-the-dart-blind-folded-comparison-of-computed-tomography-versus-magnetic-resonance-imaging-guided-brachytherapy-for-cervical-cancer-with-regard-to-dose-received-by-the-actual-targets-and-organs-at-risk
#11
Winnie Wing Ling Yip, Joyce Siu Yu Wong, Venus Wan Yan Lee, Frank Chi Sing Wong, Stewart Yuk Tung
Purpose: Computed tomography (CT) is inferior to magnetic resonance imaging (MRI) in cervical tumor delineation, but similar in identification of organs at risk (OAR). The trend to over-estimate high-risk and low-risk clinical target volume (HRCTV, IRCTV) on CT can lead to under-estimation of dose received by 90% (D90) of the 'actual' CTV. This study aims to evaluate whether CT-guided planning delivers adequate dose to the 'actual' targets while spares the OAR similarly. Material and methods: MRI-guided high-dose-rate image-guided brachytherapy (IGBT) was performed in 11 patients...
October 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29186937/how-to-use-pet-ct-in-the-evaluation-of-response-to-radiotherapy
#12
Pierre Decazes, Sébastien Thureau, Bernard Dubray, Pierre Vera
INTRODUCTION: Radiotherapy is a major treatment modality for many cancers. Tumor response after radiotherapy determines the subsequent steps of the patient's management (surveillance, adjuvant or salvage treatment and palliative care). Tumor response assessed during radiotherapy offers a promising opportunity to adapt the treatment plan to reduced / increased target volume, to specifically target sub-volumes with relevant biological characteristics (metabolism, hypoxia, proliferation ...
November 28, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29178092/-updates-of-2017-esmo-guideline-for-rectal-cancer
#13
Gong Chen, Yi Wang
Compared with the 2013 version, the basic strategies of diagnosis and treatment for rectal cancer in the 2017 version guideline remain the same. These strategies include accurate local staging approaches which combines digital rectal examination, endorectal ultrasound (ERUS), and high resolution pelvic MRI, and local recurrence risk grading system which combines tumor location/distance, T staging, N staging, EMVI (extramural vascular invasion) and MRF(mesorectal fascia). And personalized therapeutic principle based on the above local risk grading...
November 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29177928/the-bottom-line-mri-and-ct-findings-of-unusual-rectal-and-perirectal-pathology
#14
REVIEW
Stephanie Font, Candice Bolan, Melanie Caserta
Although common nonspecific symptoms (i.e., rectal bleeding, pelvic pressure, and change in bowel habits) are associated with rectal cancer, occasionally these are related to a different underlying disease. Over the past few years, considerable progress has been made in imaging of the rectum. Specifically, new magnetic resonance techniques and capabilities provide impressive high-resolution assessment of the rectal wall and enable evaluation and characterization of the perirectal tissues. This paper reviews imaging findings of uncommon causes of rectal and perirectal pathology that may be clinically confounded with rectal cancer...
November 25, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29174385/dose-warping-uncertainties-for-the-accumulated-rectal-wall-dose-in-cervical-cancer-brachytherapy
#15
Laura E van Heerden, Niek van Wieringen, Kees Koedooder, Coen R N Rasch, Bradley R Pieters, Arjan Bel
PURPOSE: Structure-based deformable image registration (DIR) can be used to calculate accumulated dose volume histogram parameters for cervical cancer brachytherapy (BT). The purpose of this study is to investigate dose warping uncertainties for the accumulated dose to the 2 cm3 receiving the highest dose [Formula: see text] in the rectal wall, using a physically realistic model (PRM) describing rectal wall deformation. METHODS AND MATERIALS: For 10 patients, treated with MRI-guided pulsed dose rate BT (two times 24 × 0...
November 22, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29127435/intensified-preoperative-chemoradiation-by-adding-oxaliplatin-in-locally-advanced-primary-operable-ct3nxm0-rectal-cancer-impact-on-long-term-outcome-results-of-the-phase%C3%A2-ii-tako-05-abcsg-r%C3%A2-02-trial
#16
P Kogler, A F DeVries, W Eisterer, J Thaler, L Sölkner, D Öfner
PURPOSE: The major goals of preoperative treatment for locally advanced rectal cancers (LARCs) are improvement of local tumor control, tumor downsizing, and downstaging. Modifications with respect to standardized chemoradiation protocol, e. g., integrating oxaliplatin, are realized with the aim of improving primary tumor response and patient outcome. PATIENTS AND METHODS: In this phase II multicenter study, patients with LARC of the mid- or lower rectum, cT3cNxcM0 as staged by MRI, were included and treated preoperatively with a combination of capecitabine and oxaliplatin following a standardized protocol during radiation...
November 10, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29102740/clinical-outcomes-with-mri-guided-image-based-brachytherapy-in-cervical-cancer-an-institutional-experience
#17
Vijai Simha, Bhavana Rai, Firuza D Patel, Rakesh Kapoor, Suresh C Sharma, Oinam A Singh, Veenu Singla, Bhaswanth Dhanireddy, Sushmita Ghoshal
PURPOSE: To evaluate the long-term disease control and toxicity to the organs at risk after dose-escalated image-based adaptive brachytherapy (BT) in cervical cancer. METHODS AND MATERIALS: Sixty patients of cervical cancer were treated with external radiotherapy 46 Gy in 23 fractions with weekly cisplatin and MRI-guided BT 7 Gy × 4 fractions with a minimum dose of 85.7 Gy (EQD2) to the high-risk clinical target volume (HRCTV). The BT dose was initially prescribed to point A and plans were optimized to ensure coverage of both point A and HRCTV while maintaining doses to the organs at risk within the recommended constraints...
November 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29101415/target-tailoring-and-proton-beam-therapy-to-reduce-small-bowel-dose-in-cervical-cancer-radiotherapy-a-comparison-of-benefits
#18
Peter de Boer, Agustinus J A J van de Schoot, Henrike Westerveld, Mark Smit, Marrije R Buist, Arjan Bel, Coen R N Rasch, Lukas J A Stalpers
PURPOSE: The aim of the study was to investigate the potential clinical benefit from both target tailoring by excluding the tumour-free proximal part of the uterus during image-guided adaptive radiotherapy (IGART) and improved dose conformity based on intensity-modulated proton therapy (IMPT). METHODS: The study included planning CTs from 11 previously treated patients with cervical cancer with a >4-cm tumour-free part of the proximal uterus on diagnostic magnetic resonance imaging (MRI)...
November 3, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29100742/outcome-of-neoadjuvant-chemoradiation-in-mri-staged-locally-advanced-rectal-cancer-retrospective-analysis-of-123-chinese-patients
#19
Shing Fung Lee, Chi Leung Chiang, Francis Ann Shing Lee, Yiu Wah Wong, Chi Ming Poon, Frank Chi Sing Wong, Stewart Yuk Tung
BACKGROUND: For advanced rectal cancer with involved or threatened mesorectal fascia (MRF), current standard is pre-operative long course chemoradiotherapy (PLCRT) with either capecitabine or 5-fluorouracil (5-FU). However, few Chinese data on its clinical outcome are available, especially for those with pelvic MRI staging. METHODS: Between Jan-2009 and Oct-2014, 123 consecutive patients with biopsy proven adenocarcinoma of rectum, all with pelvic MRI staging, selected for PLCRT after multi-disciplinary team discussion were recruited...
November 1, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29094417/defining-probabilities-of-bowel-resection-in-deep-endometriosis-of-the-rectum-prediction-with-preoperative-magnetic-resonance-imaging
#20
Alessio Perandini, Simone Perandini, Stefania Montemezzi, Cecilia Bonin, Gaia Bellini, Valentino Bergamini
AIM: Deep endometriosis of the rectum is a highly challenging disease, and a surgical approach is often needed to restore anatomy and function. Two kinds of surgeries may be performed: radical with segmental bowel resection or conservative without resection. Most patients undergo magnetic resonance imaging (MRI) before surgery, but there is currently no method to predict if conservative surgery is feasible or whether bowel resection is required. The aim of this study was to create an algorithm that could predict bowel resection using MRI images, that was easy to apply and could be useful in a clinical setting, in order to adequately discuss informed consent with the patient and plan the an appropriate and efficient surgical session...
November 2, 2017: Journal of Obstetrics and Gynaecology Research
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