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Platelet derived microparticle

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https://www.readbyqxmd.com/read/27915085/monocyte-derived-circulating-microparticles-cd14-cd14-cd11b-and-cd14-cd142-are-related-to-long-term-prognosis-for-cardiovascular-mortality-in-stemi-patients
#1
Gemma Chiva-Blanch, Vibeke Bratseth, Vibeke Ritschel, Geir Ø Andersen, Sigrun Halvorsen, Jan Eritsland, Harald Arnesen, Lina Badimon, Ingebjørg Seljeflot
BACKGROUND: Circulating microparticles (cMPs) have been proposed as novel biomarkers of cardiovascular disease (CVD). We aimed to investigate the prognostic relevance of cMPs for future major adverse cardiovascular events (MACE) in STEMI patients. METHODS: We included 200 STEMI patients treated with percutaneous coronary intervention (PCI). One hundred patients with a primary composite end point (recurrent nonfatal acute MI, rehospitalization for heart failure, unscheduled PCI or death because of CV causes) were case-matched for sex, age, and CVD risk factors to 100 patients without a primary endpoint at the end of study follow-up (4...
November 27, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27913753/neutrophil-derived-microparticles-are-released-into-the-coronary-circulation-following-percutaneous-coronary-intervention-in-acute-coronary-syndromes
#2
Gonzalo J Martinez, Jennifer Y Barraclough, Shirley Nakhla, Vivian Kienzle, Stacy Robertson, Ziad Mallat, David S Celermajer, Sanjay Patel
AIMS: To evaluate (i) local coronary and systemic levels of microparticles (MP) in Acute Coronary Syndrome (ACS) and Stable Angina Pectoris (SAP) patients and (ii) their release after plaque disruption with percutaneous coronary intervention (PCI). BACKGROUND: Microparticles are small vesicles originating from plasma membranes of cells after activation or apoptosis and are implicated in the pathogenesis of atherosclerosis. Neutrophils play a role in plaque destabilisation and shed neutrophil-derived microparticles have the potential to drive significant pro-inflammatory and thrombotic downstream effects...
December 2, 2016: Bioscience Reports
https://www.readbyqxmd.com/read/27905868/short-term-effects-of-low-let-radiation-on-the-endothelial-barrier-uncoupling-of-pecam-1-and-the-production-of-endothelial-microparticles
#3
Thomas Templin, Preety Sharma, Peter Guida, Peter Grabham
A significant target for radiation-induced effects is the microvascular system, which is critical to healthy tissue function and its pathology is linked to disrupted endothelial barrier function. Low-linear energy transfer (LET) ionizing radiation is a source of noncancer pathologies in humans and little is known about the early events that could initiate subsequent diseases. However, it is well known that gamma radiation causes a very early disruption of the endothelial barrier at doses below those required for cytotoxic effects...
December 1, 2016: Radiation Research
https://www.readbyqxmd.com/read/27901390/effects-of-various-antiplatelet-drugs-on-ex-vivo-platelet-activation-induced-by-equine-herpesvirus-type-1
#4
Daniela Hernandez, Wee Ming Yeo, Marjory B Brooks, Sally L Ness, Thomas J Divers, Tracy Stokol
OBJECTIVE To evaluate the effects of treatment of horses with standard platelet inhibitors on ex vivo inhibition of platelet activation by equine herpesvirus type I (EHV-I). ANIMALS II healthy adult horses. PROCEDURES In a double-blinded, placebo-controlled crossover study, horses were treated orally for 5 days with theophylline (5 mg/kg, q 12 h), pentoxifylline (10 mg/kg, q 12 h), clopidogrel bisulfate (4 mg/kg, q 24 h), acetylsalicylic acid (20 mg/kg, q 24 h), or placebo. Horses received all treatments, each separated by a 3-week washout period...
December 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27893349/platelet-leucocyte-and-red-cell-derived-microparticles-in-stored-whole-blood-with-and-without-leucofiltration-with-and-without-ionising-radiation
#5
Shunnichi Saito, Kenneth E Nollet, Alain M Ngoma, Takako Ono, Hitoshi Ohto
BACKGROUND: Storage lesion, including microparticle formation, has been partially characterised in whole blood, but not in all combinations of pre-storage leucofiltration and/or irradiation. MATERIALS AND METHODS: Single-donor whole blood products were processed into four subunits: with and without leucofiltration, with and without X-irradiation (25 Gy). Platelet-, leucocyte-, and erythrocyte-derived microparticles and free haemoglobin were measured periodically throughout 42 days of storage...
November 7, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27852034/thrombin-inhibition-and-cisplatin-block-tumor-progression-in-ovarian-cancer-by-alleviating-the-immunosuppressive-microenvironment
#6
Eric T Alexander, Allyson R Minton, Molly C Peters, Joanne van Ryn, Susan K Gilmour
Cancer is often associated with an increased risk of thrombotic complications which can be aggravated by treatment with chemotherapeutics such as cisplatin. Multiple lines of evidence suggest that thrombin activity promotes tumor growth and metastasis. We examined the effect of co-treatment with dabigatran etexilate, a direct thrombin inhibitor, and cisplatin using the murine ID8 ovarian cancer model. Mice receiving co-treatment with both dabigatran etexilate and low dose cisplatin had significantly smaller tumors, developed less ascites and had lower levels of circulating activated platelets and tissue factor (TF) positive microparticles than those treated with dabigatran etexilate or cisplatin alone...
November 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27832642/cell-derived-microparticles-in-patients-with-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#7
Sheyu Li, Jia Wei, Chenghui Zhang, Xiaodan Li, Wentong Meng, Xianming Mo, Qianying Zhang, Qilin Liu, Kaiyun Ren, Rong Du, Haoming Tian, Jianwei Li
BACKGROUND/AIMS: The aim of this study was to assess the association between circulating cell-derived microparticles (MPs) and type 2 diabetes mellitus (T2DM). METHODS: A literature search was performed systematically in PubMed and Embase to identify available case-control or cross-sectional studies that compared different types of cell-derived MPs in patients with T2DM and non-diabetic controls. Pooled standardized mean differences (SMDs) of each MP type were pooled using meta-analysis...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27825126/endothelial-cells-microparticle-associated-protein-disulfide-isomerase-promotes-platelet-activation-in-metabolic-syndrome
#8
Guan-Qi Fan, Ran-Ran Qin, Yi-Hui Li, Dai-Jun Song, Tong-Shuai Chen, Wei Zhang, Ming Zhong, Yun Zhang, Yan-Qiu Xing, Zhi-Hao Wang
BACKGROUND: Metabolic syndrome (MetS) is a common challenge in the world, and the platelet activation is enhanced in MetS patients. However, the fundamental mechanism that underlies platelet activation in MetS remains incompletely understood. Endothelial cells are damaged seriously in MetS patients, then they release more endothelial microparticles (EMPs). After all, whether the EMPs participate in platelet activation is still obscure. If they were, how did they work? RESULTS: We demonstrated that the levels of EMPs, PMPs (platelet derived microparticles) and microparticle-carried-PDI activity increased in MetS patients...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27821539/endothelial-microparticles-from-acute-coronary-syndrome-patients-induce-premature-coronary-artery-endothelial-cells-ageing-and-thrombogenicity-role-of-the-ang-ii-at1-receptor-nadph-oxidase-mediated-activation-of-mapks-and-pi3-kinase-pathways
#9
Malak Abbas, Laurence Jesel, Cyril Auger, Lamia K Amoura, Nathan Messas, Guillaume Manin, Cordula Rumig, Antonio J León-González, Thais P Ribeiro, Grazielle C Silva, Raghida Abou-Merhi, Eva Hamade, Markus Hecker, Yannick Georg, Nabil Chakfe, Patrick Ohlmann, Valérie B Schini-Kerth, Florence Toti, Olivier Morel
BACKGROUND: -Microparticles (MPs) have emerged as a surrogate marker of endothelial dysfunction and cardiovascular risk. This study examined the potential of MPs from senescent endothelial cells (ECs) or from patients with acute coronary syndrome (ACS) to promote premature ECs ageing and thrombogenicity. METHODS: -Primary porcine coronary ECs were isolated from the left circumflex coronary artery. MPs were prepared from ECs and venous blood from patients with ACS (n=30) and from healthy volunteers (n=6) by sequential centrifugation...
November 7, 2016: Circulation
https://www.readbyqxmd.com/read/27758933/mpges-1-deletion-affects-platelet-functions-in-mice
#10
Joan Raouf, Fariborz Mobarrez, Karin Larsson, Per-Johan Jakobsson, Marina Korotkova
Microsomal prostaglandin E2 synthase-1 (mPGES-1) constitutes an essential player of inflammation and is involved in the pathogenesis of rheumatoid arthritis (RA). Platelets participate in the regulation of inflammatory processes by the release of pro-inflammatory mediators and platelet-derived microparticles (PMPs). However, the role of the inducible mPGES-1/PGE2 pathway on platelet functions has not been investigated. Here we report a significant impact of mPGES-1 on platelet functions during inflammation...
October 7, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27698012/von-willebrand-factor-interacts-with-surface-bound-c1q-and-induces-platelet-rolling
#11
Robert Kölm, Monica Schaller, Lubka T Roumenina, Iga Niemiec, Johanna A Kremer Hovinga, Elham Khanicheh, Beat A Kaufmann, Helmut Hopfer, Marten Trendelenburg
Premature atherosclerosis and thrombotic complications are major causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE). However, the high incidence of these complications cannot be explained by traditional risk factors alone, suggesting direct effects of an activated immune system on hemostasis. The unexpected nucleotide sequence homology between SLE patient -: derived autoantibodies against complement C1q (Fab anti-C1q) and von Willebrand factor (VWF) led us to investigate a potential interaction between the complement and hemostatic systems on the level of initiating molecules...
October 3, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27695417/antiplatelet-agents-inhibit-the-generation-of-platelet-derived-microparticles
#12
Alice Giacomazzi, Maurizio Degan, Stefano Calabria, Alessandra Meneguzzi, Pietro Minuz
Platelet microparticles (PMPs) contribute to thrombogenesis but the effects of antiplatelet drugs on PMPs generation is undefined. The present study investigated the cellular events regulating PMPs shedding, testing in vitro platelet agonists and inhibitors. Platelet-rich plasma from healthy subjects was stimulated with arachidonic acid (AA), U46619, collagen type-I (10 and 1.5 μg/mL), epinephrine, ADP or TRAP-6 and pre-incubated with acetylsalicylic acid (ASA, 100 and 10 μmol/L), SQ-29,548, apyrase, PSB-0739, or eptifibatide...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27667507/characterization-of-microparticles-in-patients-with-venous-malformations-of-the-head-and-neck
#13
J-Y Zhu, J-G Ren, W Zhang, F-Q Wang, Y Cai, J-H Zhao, G Chen, Y-F Zhao
OBJECTIVES: To determine the basic biochemical features of microparticles (MP) in patients with venous malformation (VM) of the head and neck. METHODS: Microparticles were isolated from peripheral venous blood of VM patients or healthy subjects and from lesional fluid of VM patients. Flow cytometry and real-time polymerase chain reaction were employed to determine the concentration, cellular origin, and RNA expression of obtained MP. A functional coagulation test was applied to measure the coagulant activity of MP...
September 26, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27662257/standardization-of-microparticle-enumeration-across-different-flow-cytometry-platforms-results-of-a-multicenter-collaborative-workshop
#14
S Cointe, C Judicone, S Robert, M J Mooberry, P Poncelet, M Wauben, R Nieuwland, N S Key, F Dignat-George, R Lacroix
BACKGROUND: Microparticles are extracellular vesicles resulting from the budding of cellular membranes that have a high potential as emergent biomarkers; however, their clinical relevance is hampered by methodological enumeration concerns and a lack of standardization. Flow cytometry (FCM) remains the most commonly used technique with the best capability to determine the cellular origin of single MPs. However, instruments behave variably depending on which scatter parameter, (Forward (FSC) or Side scatter (SSC)), provides the best resolution to discriminate submicron particles...
September 23, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27638154/assessment-of-bone-healing-ability-of-calcium-phosphate-cements-loaded-with-platelet-lysate-in-rat-calvarial-defects
#15
Pedro S Babo, Pedro P Carvalho, Vítor E Santo, Susana Faria, Manuela E Gomes, Rui L Reis
Injectable calcium phosphate cements have been used as a valid alternative to autologous bone grafts for bone augmentation with the additional advantage of enabling minimally invasive implantation procedures and for perfectly fitting the tissue defect. Nevertheless, they have low biodegradability and lack adequate biochemical signaling to promote bone healing and remodeling. In previous in vitro studies, we observed that the incorporation of platelet lysate directly into the cement paste or loaded in hyaluronic acid microspheres allowed to modulate the cement degradation and the in vitro expression of osteogenic markers in seeded human adipose derived stem cells...
September 16, 2016: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/27633722/red-wine-prevents-the-acute-negative-vascular-effects-of-smoking
#16
V Schwarz, K Bachelier, S H Schirmer, C Werner, U Laufs, M Böhm
BACKGROUND: Moderate consumption of red wine is associated with less cardiovascular events. We investigated whether red wine consumption counteracts the adverse vascular effects of cigarette smoking. METHODS: Participants smoked three cigarettes, alone or after drinking a titrated volume of red wine. Clinical chemistry, blood counts, plasma cytokine ELISAs, immuno-magnetic separation of CD14(+) monocytes for gene expression analysis, fluorescence-activated cell sorting for microparticles, isolation of circulating mononuclear cells to measure telomerase activity were performed and urine cotinine levels were quantified...
September 12, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27623086/platelets-confound-the-measurement-of-extracellular-mirna-in-archived-plasma
#17
Adam J Mitchell, Warren D Gray, Salim S Hayek, Yi-An Ko, Sheena Thomas, Kim Rooney, Mosaab Awad, John D Roback, Arshed Quyyumi, Charles D Searles
Extracellular miRNAs are detectable in biofluids and represent a novel class of disease biomarker. Although many studies have utilized archived plasma for miRNA biomarker discovery, the effects of processing and storage have not been rigorously studied. Previous reports have suggested plasma samples are commonly contaminated by platelets, significantly confounding the measurement of extracellular miRNA, which was thought to be easily addressed by additional post-thaw plasma processing. In a case-control study of archived plasma, we noted a significant correlation between miRNA levels and platelet counts despite post-thaw processing...
September 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27597127/development-of-a-nanobioanalytical-platform-for-on-chip-qualification-and-quantification-of-platelet-derived-microparticles
#18
Sameh Obeid, Adam Ceroi, Guillaume Mourey, Philippe Saas, Celine Elie-Caille, Wilfrid Boireau
Blood microparticles (MPs) are small membrane vesicles (50-1000nm), derived from different cell types. They are known to play important roles in various biological processes and also recognized as potential biomarkers of various health disorders. Different methods are currently used for the detection and characterization of MPs, but none of these methods is capable to quantify and qualify total MPs at the same time, hence, there is a need to develop a new approach for simultaneous detection, characterization and quantification of microparticles...
August 29, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27556645/modification-of-pulsed-electric-field-conditions-results-in-distinct-activation-profiles-of-platelet-rich-plasma
#19
Andrew L Frelinger, Anja J Gerrits, Allen L Garner, Andrew S Torres, Antonio Caiafa, Christine A Morton, Michelle A Berny-Lang, Sabrina L Carmichael, V Bogdan Neculaes, Alan D Michelson
BACKGROUND: Activated autologous platelet-rich plasma (PRP) used in therapeutic wound healing applications is poorly characterized and standardized. Using pulsed electric fields (PEF) to activate platelets may reduce variability and eliminate complications associated with the use of bovine thrombin. We previously reported that exposing PRP to sub-microsecond duration, high electric field (SMHEF) pulses generates a greater number of platelet-derived microparticles, increased expression of prothrombotic platelet surfaces, and differential release of growth factors compared to thrombin...
2016: PloS One
https://www.readbyqxmd.com/read/27537737/microparticles-and-blood-cells-induce-procoagulant-activity-via-phosphatidylserine-exposure-in-nstemi-patients-following-stent-implantation
#20
Lixiu Wang, Yayan Bi, Muhua Cao, Ruishuang Ma, Xiaoming Wu, Yan Zhang, Wenbo Ding, Yan Liu, Qian Yu, Yingqian Zhang, Hua Jiang, Yingchun Sun, Dongxia Tong, Li Guo, Zengxiang Dong, Ye Tian, Junjie Kou, Jialan Shi
BACKGROUND: Relatively little is known about the role of phosphatidylserine (PS) in procoagulant activity (PCA) in patients with non-ST-elevated myocardial infarction (NSTEMI) after stent implantation. This study was designed to evaluate whether exposed PS on microparticles (MPs) and blood cells were involved in the hypercoagulable state in NSTEMI patients with stent implantation. METHODS: NSTEMI patients (n=90) and healthy controls (n=20) were included in our study...
November 15, 2016: International Journal of Cardiology
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