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https://www.readbyqxmd.com/read/29571276/estimating-the-clinical-effectiveness-and-value-based-price-range-of-erenumab-for-the-prevention-of-migraine-in-patients-with-prior-treatment-failures-a-us-societal-perspective
#1
Richard B Lipton, Alan Brennan, Stephen Palmer, Anthony J Hatswell, Joshua K Porter, Sandhya Sapra, Guillermo Villa, Neel Shah, Stewart Tepper, David Dodick
BACKGROUND: Frequent migraine with four or more headache days per month is a common, disabling neurovascular disease. From a US societal perspective, this analysis models the clinical efficacy and estimates the value-based price (VBP) for erenumab, a fully human monoclonal antibody that inhibits the calcitonin gene-related peptide receptor. METHODS: A Markov health state transition model was developed to estimate the incremental costs, quality-adjusted life-years (QALYs), and value-based price range for erenumab in migraine prevention...
April 3, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29566830/affordability-challenges-to-value-based-pricing-mass-diseases-orphan-diseases-and-cures
#2
Patricia M Danzon
OBJECTIVES: To analyze how value-based pricing (VBP), which grounds the price paid for pharmaceuticals in their value, can manage "affordability" challenges, defined as drugs that meet cost-effectiveness thresholds but are "unaffordable" within the short-run budget. METHODS: Three specific contexts are examined, drawing on recent experience. First, an effective new treatment for a chronic, progressive disease, such as hepatitis C, creates a budget spike that is transitory because initial prevalence is high, relative to current incidence...
March 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29554932/association-between-canine-leishmaniosis-and-ehrlichia-canis-co-infection-a-prospective-case-control-study
#3
Charalampos Attipa, Laia Solano-Gallego, Kostas Papasouliotis, Francesca Soutter, David Morris, Chris Helps, Scott Carver, Séverine Tasker
BACKGROUND: In the Mediterranean basin, Leishmania infantum is a major cause of disease in dogs, which are frequently co-infected with other vector-borne pathogens (VBP). However, the associations between dogs with clinical leishmaniosis (ClinL) and VBP co-infections have not been studied. We assessed the risk of VBP infections in dogs with ClinL and healthy controls. METHODS: We conducted a prospective case-control study of dogs with ClinL (positive qPCR and ELISA antibody for L...
March 20, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29554931/clinical-evaluation-of-outdoor-cats-exposed-to-ectoparasites-and-associated-risk-for-vector-borne-infections-in-southern-italy
#4
Maria Flaminia Persichetti, Maria Grazia Pennisi, Angela Vullo, Marisa Masucci, Antonella Migliazzo, Laia Solano-Gallego
BACKGROUND: Cats can be carriers of infected arthropods and be infected with several vector-borne pathogens (VBP) but there is limited knowledge about their pathogenic role in cats. RESULTS: A cross-sectional controlled study investigated the clinical status and antibody (Bartonella henselae, Rickettsia conorii, Ehrlichia canis, Anaplasma phagocytophilum, Babesia microti and Leishmania infantum) and/or blood PCR (Mycoplasma spp., Bartonella spp., Rickettsia spp...
March 20, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29417574/medicare-payment-penalties-and-safety-net-hospital-profitability-minimal-impact-on-these-vulnerable-hospitals
#5
Gloria J Bazzoli, Michael P Thompson, Teresa M Waters
OBJECTIVE: To examine relationships between penalties assessed by Medicare's Hospital Readmission Reduction Program and Value-Based Purchasing Program and hospital financial condition. DATA SOURCES/STUDY SETTING: Centers for Medicare and Medicaid Services, American Hospital Association, and Area Health Resource File data for 4,824 hospital-year observations. STUDY DESIGN: Bivariate and multivariate analysis of pooled cross-sectional data. PRINCIPAL FINDINGS: Safety net hospitals have significantly higher HRRP/VBP penalties, but, unlike nonsafety net hospitals, increases in their penalty rate did not significantly affect their total margins...
February 8, 2018: Health Services Research
https://www.readbyqxmd.com/read/29402703/tibial-nerve-stimulation-to-drive-genital-sexual-arousal-in-an-anesthetized-female-rat
#6
Lauren L Zimmerman, Indie C Rice, Mitchell B Berger, Tim M Bruns
BACKGROUND: There is clinical evidence that percutaneous tibial nerve stimulation can positively benefit women with female sexual interest/arousal disorder, yet no studies have explored the potential mechanisms further. AIM: To investigate the effect of tibial nerve stimulation on vaginal blood perfusion (VBP) in an anesthetized rat model. METHODS: 16 ketamine-anesthetized rats were surgically implanted with a nerve cuff electrode on 1 tibial nerve...
February 3, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29220424/genetically-deprived-vitamin-d-exposure-predisposes-to-atrial-fibrillation
#7
Yap-Hang Chan, Kai-Hang Yiu, Jo Jo Hai, Pak-Hei Chan, Tai-Hing Lam, Ben J Cowling, Pak-Chung Sham, Chu-Pak Lau, Karen Siu-Ling Lam, Chung-Wah Siu, Hung-Fat Tse
Aims: Low vitamin D level is associated with atrial fibrillation (AF) and may be implicated in its pathogenesis. Methods and results: We studied single nucleotide polymorphisms (SNPs) of vitamin D mechanistic pathways and serum 25-hydroxyvitamin D [25(OH)D] levels in an age- and gender-matched case-control study (controls without AF: mean age 68.6 ± 8.7 years, female 25%; n = 1019; with AF: mean age 69.7 ± 9.5 years, female 30%; n = 156) recruited from a Chinese clinical cohort of patients with stable coronary artery disease...
December 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28940295/comparing-leukapheresis-protocols-for-an-aml-patient-with-symptomatic-leukostasis
#8
Abigail Cline, Ryan Jajosky, James Shikle, Roni Bollag
BACKGROUND: Acute myeloid leukemia (AML) is a malignancy characterized by rapid clonal proliferation of myeloid precursors, which can result in hyperleukocytosis. Leukapheresis can be used to rapidly reduce the white blood cell count (WBC). However, the only FDA cleared device for WBC depletion, the COBE Spectra, will no longer be supported by the manufacturer in 2017, and there are few studies comparing different methods of leukapheresis. CASE REPORT: A 68-year-old African American female was admitted to the hospital for relapse of her AML...
September 22, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28805361/medicare-program-hospital-inpatient-prospective-payment-systems-for-acute-care-hospitals-and-the-long-term-care-hospital-prospective-payment-system-and-policy-changes-and-fiscal-year-2018-rates-quality-reporting-requirements-for-specific-providers-medicare
#9
(no author information available yet)
We are revising the Medicare hospital inpatient prospective payment systems (IPPS) for operating and capital-related costs of acute care hospitals to implement changes arising from our continuing experience with these systems for FY 2018. Some of these changes implement certain statutory provisions contained in the Pathway for Sustainable Growth Rate (SGR) Reform Act of 2013, the Improving Medicare Post-Acute Care Transformation Act of 2014, the Medicare Access and CHIP Reauthorization Act of 2015, the 21st Century Cures Act, and other legislation...
August 14, 2017: Federal Register
https://www.readbyqxmd.com/read/28692071/-charges-and-convictions-of-psychiatrists-for-the-violent-behavior-of-the-patient-psychiatric-forensic-remarks
#10
Giancarlo Nivoli, Liliana Lorettu, Bernardo Carpiniello, Paolo Milia, Federica Pinna, Andrea Lepretti, Cristiano Depalmas, Alessandra M A Nivoli
Purpose of the present study is to point-out a number of psychiatric-forensic remarks about the management of violent behavior against the person (VBP) amongst psychiatric patients. The study is the authors' personal contribution based on clinical and forensic experience as experts in the management of psychiatric patients with VBP. Twelve psychiatric-forensic remarks have been highlighted in the present study: 1) VBP is a multifactorial event; 2) the risk of VBP against the person may change rapidly over time in quantity and quality; 3) there are no methods for reliable prediction of VBP in a single clinical-case; 4) there are no medications with an indication of "heal" the VBP; 5) there are no therapeutic measures that neutralize always, quickly and without recurrences VBP; 6) there exist clinical hypotheses to assess VBP; 7) there exist principles of victimology to assess VBP; 8) there are emotional reactions that can affect the evaluation and clinical and forensic management of VBP; 9) the responsibility of the psychiatrist has to be evaluated at the moment of the events; 10) the responsibility of the psychiatrist must be contextualized in the single clinical-case; 11) there is the need to clarify the individual professional responsibility of psychiatrists who treated a patient; 12) there is the need to clarify the criteria for the definition of the guarantee role...
May 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/28579517/early-regional-wall-distension-is-strongly-associated-with-vulnerability-to-ventricular-fibrillation-but-not-arrhythmia-triggers-following-coronary-occlusion-in-vivo
#11
José A Barrabés, Javier Inserte, Antonio Rodríguez-Sinovas, Marisol Ruiz-Meana, David Garcia-Dorado
Wall stress may favor ischemic ventricular arrhythmias, yet its association with ventricular fibrillation (VF) or ventricular ectopy has been inconsistent among studies and its potential arrhythmogenicity across the cardiac cycle is unclear. In 91 open-chest pigs undergoing 40-50 min left anterior descending artery occlusion, we assessed the association between diastolic or systolic distension of the ischemic area and the incidence of ventricular premature beats (VPBs) and VF. End-diastolic segment length (EDL) and systolic bulging ([maximum systolic length-EDL] × 100/EDL) were measured by ultrasonic crystals...
November 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28562306/statement-of-the-problem-health-reform-value-based-purchasing-alternative-payment-strategies-and-children-and-youth-with-special-health-care-needs
#12
Sara S Bachman, Meg Comeau, Thomas F Long
There is increasing interest in maximizing health care purchasing value by emphasizing strategies that promote cost-effectiveness while achieving optimal health outcomes. These value-based purchasing (VBP) strategies have largely focused on adult health, and little is known about the impact of VBP program development and implementation on children, especially children and youth with special health care needs (CYSHCN). With the increasing emphasis on VBP, policymakers must critically analyze the potential impact of VBP for CYSCHN, because this group of children, by definition, uses more health care services than other children and inevitably incurs higher per person costs...
May 2017: Pediatrics
https://www.readbyqxmd.com/read/28558604/hospitals-known-for-nursing-excellence-perform-better-on-value-based-purchasing-measures
#13
COMPARATIVE STUDY
Karen B Lasater, Hayley D Germack, Dylan S Small, Matthew D McHugh
It is well-established that hospitals recognized for good nursing care - Magnet hospitals - are associated with better patient outcomes. Less is known about how Magnet hospitals compare to non-Magnets on quality measures linked to Medicare reimbursement. The purpose of this study was to determine how Magnet hospitals perform compared to matched non-Magnet hospitals on Hospital Value Based Purchasing (VBP) measures. A cross-sectional analysis of three linked data sources was performed. The sample included 3,021 non-federal acute care hospitals participating in the VBP program (323 Magnets; 2,698 non-Magnets)...
November 2016: Policy, Politics & Nursing Practice
https://www.readbyqxmd.com/read/28448211/prevalence-and-geographic-distribution-of-vector-borne-pathogens-in-apparently-healthy-dogs-in-croatia
#14
Vladimir Mrljak, Josipa Kuleš, Željko Mihaljević, Marin Torti, Jelena Gotić, Martina Crnogaj, Tatjana Živičnjak, Iva Mayer, Iva Šmit, Mangesh Bhide, Renata Barić Rafaj
Vector-borne pathogens (VBPs) are a group of globally extended and quickly spreading pathogens that are transmitted by various arthropod vectors. The aim of the present study was to investigate the seroprevalence against Babesia canis, Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato, Leishmania infantum, Dirofilaria immitis, and Ehrlichia canis in dogs in Croatia. We investigated 435 randomly selected apparently healthy dogs in 13 different locations of Croatia for antibodies to B. canis by indirect immunofluorescence using a commercial IFA IgG Antibody Kit...
June 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28367375/the-hospital-score-and-lace-index-as-predictors-of-30-day-readmission-in-a-retrospective-study-at-a-university-affiliated-community-hospital
#15
Robert Robinson, Tamer Hudali
INTRODUCTION: Hospital readmissions are common, expensive, and a key target of the Medicare Value Based Purchasing (VBP) program. Validated risk assessment tools such as the HOSPITAL score and LACE index have been developed to identify patients at high risk of hospital readmission so they can be targeted for interventions aimed at reducing the rate of readmission. This study aims to evaluate the utility of HOSPITAL score and LACE index for predicting hospital readmission within 30 days in a moderate-sized university affiliated hospital in the midwestern United States...
2017: PeerJ
https://www.readbyqxmd.com/read/28285583/molecular-detection-of-vector-borne-pathogens-in-blood-and-splenic-samples-from-dogs-with-splenic-disease
#16
Rebeca Movilla, Laura Altet, Lorena Serrano, María-Dolores Tabar, Xavier Roura
BACKGROUND: The spleen is a highly perfused organ involved in the immunological control and elimination of vector-borne pathogens (VBP), which could have a fundamental role in the pathogenesis of splenic disease. This study aimed to evaluate certain VBP in samples from dogs with splenic lesions. METHODS: Seventy-seven EDTA-blood and 64 splenic tissue samples were collected from 78 dogs with splenic disease in a Mediterranean area. Babesia spp., Bartonella spp., Ehrlichia/Anaplasma spp...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28141930/value-based-payment-in-implementing-evidence-based-care-the-mental-health-integration-program-in-washington-state
#17
Yuhua Bao, Thomas G McGuire, Ya-Fen Chan, Ashley A Eggman, Andrew M Ryan, Martha L Bruce, Harold Alan Pincus, Erin Hafer, Jürgen Unützer
OBJECTIVES: To assess the role of value-based payment (VBP) in improving fidelity and patient outcomes in community implementation of an evidence-based mental health intervention, the Collaborative Care Model (CCM). STUDY DESIGN: Retrospective study based on a natural experiment. METHODS: We used the clinical tracking data of 1806 adult patients enrolled in a large implementation of the CCM in community health clinics in Washington state. VBP was initiated in year 2 of the program, creating a natural experiment...
January 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28122873/rising-stakes-for-health-care-associated-infection-prevention-implications-for-the-clinical-microbiology-laboratory
#18
Daniel J Diekema
Health care-associated infection (HAI) rates are subject to public reporting and are linked to hospital reimbursement from the Centers for Medicare and Medicaid Services (CMS). The increasing pressure to lower HAI rates comes at a time when advances in the clinical microbiology laboratory (CML) provide more-precise and -sensitive tests, altering HAI detection in ways that may increase reported HAI rates. I review how changing CML practices can impact HAI rates and how the financial implications of HAI metrics may produce pressure to change diagnostic testing practices...
April 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28089185/joint-replacement-volume-positively-correlates-with-improved-hospital-performance-on-centers-for-medicare-and-medicaid-services-quality-metrics
#19
Rachel A Sibley, Vanessa Charubhumi, Lorraine H Hutzler, Albit R Paoli, Joseph A Bosco
BACKGROUND: The Center for Medicare and Medicaid Services (CMS) is transitioning Medicare from a fee-for-service program into a value-based pay-for-performance program. In order to accomplish this goal, CMS initiated 3 programs that attempt to define quality and seek to reward high-performing hospitals and penalize poor-performing hospitals. These programs include (1) penalties for hospital-acquired conditions (HACs), (2) penalties for excess readmissions for certain conditions, and (3) performance on value-based purchasing (VBP)...
May 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28072793/merit-based-incentive-payment-system-meaningful-changes-in-the-final-rule-brings-cautious-optimism
#20
Laxmaiah Manchikanti, Standiford Helm Ii, Aaron K Calodney, Joshua A Hirsch
The Medicare Access and CHIP Reauthorization Act of 2015 (MACRA) eliminated the flawed Sustainable Growth Rate (SGR) act formula - a longstanding crucial issue of concern for health care providers and Medicare beneficiaries. MACRA also included a quality improvement program entitled, "The Merit-Based Incentive Payment System, or MIPS." The proposed rule of MIPS sought to streamline existing federal quality efforts and therefore linked 4 distinct programs into one. Three existing programs, meaningful use (MU), Physician Quality Reporting System (PQRS), value-based payment (VBP) system were merged with the addition of Clinical Improvement Activity category...
January 2017: Pain Physician
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