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https://www.readbyqxmd.com/read/28523589/alternating-acetaminophen-and-ibuprofen-versus-monotherapies-in-improvements-of-distress-and-reducing-refractory-fever-in-febrile-children-a-randomized-controlled-trial
#1
Shuanghong Luo, Mengdong Ran, Qiuhong Luo, Min Shu, Qin Guo, Yu Zhu, Xiaoping Xie, Chongfan Zhang, Chaomin Wan
BACKGROUND: No evidence can be found in the medical literature about the efficacy of alternating acetaminophen and ibuprofen treatment in children with refractory fever. OBJECTIVE: Our objective was to assess the effect of alternating acetaminophen and ibuprofen therapy on distress and refractory fever compared with acetaminophen or ibuprofen as monotherapy in febrile children. METHODS: A total of 474 febrile children with axillary temperature ≥38...
May 18, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28499592/risk-factors-for-poor-outcomes-of-children-with-acute-acalculous-cholecystitis
#2
Yi-An Lu, Cheng-Hsun Chiu, Man-Shan Kong, Han-I Wang, Hsun-Chin Chao, Chien-Chang Chen
BACKGROUND: Acute acalculous cholecystitis (AAC) is generally considered to be a mild disease in children; however, if left untreated or treated without caution, AAC can lead to severe outcomes, such as death. The objectives of this study were to present the clinical features and identify the predictors of mortality in pediatric AAC. METHODS: Patients diagnosed with AAC between 2005 and 2012 were enrolled. AAC was defined by the presence of fever and an echo-proven thickened gallbladder wall exceeding 4 mm...
March 25, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28498230/high-frequency-of-neuroimaging-abnormalities-among-pediatric-patients-with-sepsis-who-undergo-neuroimaging
#3
Mary K Sandquist, Mark S Clee, Smruti K Patel, Kelli A Howard, Toni Yunger, Usha D Nagaraj, Blaise V Jones, Lin Fei, Sudhakar Vadivelu, Hector R Wong
OBJECTIVES: This study was intended to describe and correlate the neuroimaging findings in pediatric patients after sepsis. DESIGN: Retrospective chart review. SETTING: Single tertiary care PICU. PATIENTS: Patients admitted to Cincinnati Children's Hospital Medical Center with a discharge diagnosis of sepsis or septic shock between 2004 and 2013 were crossmatched with patients who underwent neuroimaging during the same time period...
May 11, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28484494/antimicrobial-resistance-of-salmonella-enterica-serovars-typhi-and-paratyphi-isolates-from-a-general-hospital-in-karawaci-tangerang-indonesia-a-five-year-review
#4
Nata Pratama Hardjo Lugito, Cucunawangsih
Typhoid and paratyphoid fever known as enteric fever pose important global public health problem, with 21.6 million cases and approximately 250,000 deaths annually. It is a prevalent disease in Indonesia, but data on the antimicrobial resistance pattern is limited. This study aim was to provide data on the antimicrobial resistance pattern of S. Typhi and S. Paratyphi bloodstream isolates in a general hospital in Karawaci, Tangerang, Banten, Indonesia, during the period of January 2011 to December 2015. Susceptibility against antimicrobials was detected according to the guidelines of the Clinical and Laboratory Standards Institute (CLSI)...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/28482392/-three-cases-with-familial-mediterranean-fever-misdiagnosed-as-juvenile-idiopathic-arthritis
#5
J Li, Y Zhang, W Wang, L Q Zhong, H M Song
Objective: To explore the key points of diagnosis and treatment of familial Mediterranean fever(FMF). Method: The clinical data of 3 cases with FMF misdiagnosed as Juvenile idiopathic arthritis(JIA)seen from January 2014 to June 2016 in Peking Union Medical College Hospital were retrospectively collected. The clinical manifestations, gene mutation characteristics, treatment and prognosis were also evaluated. Result: Two cases were male and 1 was female. The mean age of onset was 17 months (3 months to 36 months), while the average age of diagnosis was 6 years and 8 months (24 months to 11 years)...
May 4, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28471400/epidemiology-and-management-of-acute-haematogenous-osteomyelitis-in-a-tertiary-paediatric-center
#6
Elena Chiappini, Caterina Camposampiero, Simone Lazzeri, Giuseppe Indolfi, Maurizio De Martino, Luisa Galli
Background: Paediatric acute hematogenous osteomyelitis (AHOM) is a serious disease requiring early diagnosis and treatment. To review the clinical presentation, management and organisms responsible for AHOM, and to explore risk factors for complicated AHOM, a large cohort referring to a single center over a 6-year period was evaluated. Methods: Data from children with AHOM, hospitalized between 2010 and 2015, and aged > 1 month, were retrospectively collected and analyzed. Results: 121 children (median age 4...
May 4, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28470578/acute-hemorrhagic-edema-of-infancy-the-experience-of-a-large-tertiary-pediatric-center-in-israel
#7
Limor Parker, Keren Shahar-Nissan, Liat Ashkenazi-Hoffnung, Liora Harel, Jacob Amir, Omer Trivizki, Efraim Bilavsky
BACKGROUND: Acute hemorrhagic edema of infancy (AHEI) is a rare leukocytoclastic vasculitis of the small vessels occurring at a young age and considered as a benign self-limited disease. Due to its low prevalence, there are limited data on the presentation and complications of this disease. METHODS: All computerized files of children who were hospitalized at a tertiary pediatric center due to AHEI over a 10 year period were reviewed. Clinical, laboratory and histopathological data were collected...
April 29, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28468073/-characteristics-on-the-onset-features-of-scarlet-fever-in-beijing-2006-2015
#8
S S Wu, C N Ma, X M Peng, D T Zhang, Q Y Wang, P Yang
Objective: This study aimed to explore the incidence trends and onset features of scarlet fever during the years of epidemic, from 2006 to 2015, in Beijing. Methods: Spatial, temporal and population distributions, prognosis of the reported cases and surveillance data on scarlet fever and other streptococcal infections (including the patients of streptococcal infection, tonsillitis and isthmitis) were analyzed by the descriptive epidemiological methods. Results: A total of 27 987 scarlet fever cases were reported from 2006 to 2015, with the incidence rates as 7...
April 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28466611/occult-bacteremia-should-we-look-for-the-needle-in-the-haystack
#9
Neta Baram, Orli Megged, Giora Weiser
BACKGROUND: Once a well-recognized entity, occult bacteremia (OB) is no longer a significant or serious bacterial infection. First following the introduction of the Haemophilus influenzae type B vaccine and now with the implementation of the conjugate pneumococcal vaccine (PCV), the number of cases has declined significantly. This has led to a change in many published guidelines to avoid taking blood cultures in fully vaccinated children presenting with fever. In Israel, the introduction of the PCV13 is now widespread...
November 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28462757/can-whole-blood-parameters-be-used-in-follow-up-of-children-with-rheumatic-valvular-heart-disease
#10
Derya Karpuz, Dilek Giray, Abdullah Ozyurt, Gulcin Bozlu, Selma Unal, Olgu Hallioglu
OBJECTIVES: The aim of the present study was to investigate the relationships between red blood cell distribution width, platelet distribution width, and mean platelet volume and the presence and severity of valvular involvement in patients with rheumatic heart disease. METHODS: Between April, 2012 and December, 2015, 151 patients who were admitted to the Pediatric Cardiology Unit with diagnosis of rheumatic heart disease and 148 healthy children were included to our study...
May 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28452841/are-we-over-treating-insect-bite-related-periorbital-cellulitis-in-children-the-experience-of-a-large-tertiary-care-pediatric-hospital
#11
Nadav Friedel, Dennis Scolnik, Ayelet Rimon, Rotem Orbach, Sharon Laat, Miguel M Glatstein
INTRODUCTION: Preseptal (periorbital) and orbital cellulitis are potentially catastrophic infections near the eye. Preseptal cellulitis is far more common, and although classically reported to be associated with dacrocystitis, sinusitis/upper respiratory infection, trauma/surgery, or infection from contiguous areas, it can also be associated with insect bites. The objective of this study was to determine the prevalence of insect bite-associated preseptal cellulitis and to compare clinical findings and outcomes of these patients with those having other causes for the condition...
April 25, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/28451045/-prelabour-rupture-of-membranes-prom-at-term-prognostic-factors-and-neonatal-consequences
#12
Asmama Yasmina, Amina Barakat
Prelabour rupture of membranes (PROM) at term occurs in 5 to 10% of pregnancies. It accounts for a significant proportion of neonatal morbidity and mortality. The aim of this case study was to determine the maternal and obstetric prognostic factors as well as full-term newborns outcomes in pregnancies complicated by prelabour rupture of membranes in patients hospitalized or managed at the outpatient clinic. We conducted a retrospective study of all cases of full-term infants born to mothers whose pregnancy was complicated by PROM, recorded in the neonatology department at the Children's Hospital of Rabat between 1 January and 31 July 2014...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28448685/adult-neurobehavioral-alterations-in-male-and-female-mice-following-developmental-exposure-to-paracetamol-acetaminophen-characterization-of-a-critical-period
#13
Gaëtan Philippot, Torsten Gordh, Anders Fredriksson, Henrik Viberg
Paracetamol (acetaminophen) is a widely used non-prescription drug with analgesic and antipyretic properties. Among pregnant women and young children, paracetamol is one of the most frequently used drugs and is considered the first-choice treatment for pain and/or fever. Recent findings in both human and animal studies have shown associations between paracetamol intake during brain development and adverse behavioral outcomes later in life. The present study was undertaken to investigate if the induction of these effects depend on when the exposure occurs during a critical period of brain development and if male and female mice are equally affected...
April 27, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28442182/a-retrospective-study-acute-rheumatic-fever-and-post-streptococcal-reactive-arthritis-in-japan
#14
Satoshi Sato, Yoji Uejima, Eisuke Suganuma, Tadamasa Takano, Yutaka Kawano
BACKGROUND: Acute rheumatic fever (ARF) and post-streptococcal reactive arthritis (PSRA) are immune-mediated consequences of group A streptococcal pharyngitis. ARF has declined in developed nations. No prevalence survey of PSRA has been conducted. This study evaluated the incidence and characteristics of ARF and PSRA in Japanese children. METHODS: From 2010 to 2015, ARF and PSRA were evaluated using clinical data retrospectively collected by chart review from 528 hospitals...
April 22, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28427379/novel-mutation-identified-in-severe-early-onset-tumor-necrosis-factor-receptor-associated-periodic-syndrome-a-case-report
#15
Suhas M Radhakrishna, Amy Grimm, Lori Broderick
BACKGROUND: Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS) is the second most common heritable autoinflammatory disease, typically presenting in pre-school aged children with fever episodes lasting 1-3 weeks. Systemic symptoms can include rash, myalgia, ocular inflammation, and serositis. CASE PRESENTATION: Here we report an unusual presentation of TRAPS in a 7 month old girl who presented with only persistent fever. She was initially diagnosed with incomplete Kawasaki Disease and received IVIG and infliximab; however, her fevers quickly recurred...
April 20, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28419020/education-in-the-waiting-room-description-of-a-pediatric-emergency-department-educational-initiative
#16
Sarah Reid, Gina Neto, Sandy Tse, Ken J Farion, Ariyan Marvizi, Lauren Smith, Chantalle Clarkin, Kristina Rohde, Katherine Moreau
OBJECTIVE: The aim of this study was to understand parents' awareness of and reactions to a slide presentation based waiting-room educational initiative. METHODS: This was a prospective observational study at a Canadian tertiary-care pediatric emergency department (ED) with an annual census of 68,000 visits. An anonymous parental survey was developed de novo, and parents were asked to complete the survey during their low-acuity ED visit over a 2-week study period...
April 18, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28409889/mobilization-patterns-of-children-on-a-hematology-oncology-inpatient-ward
#17
Krista Johnston, Robin Deliva, Cathy Evans
BACKGROUND: Children being treated for cancer are admitted to the hospital for treatment of their disease or complications of therapy. Periods of bed rest during hospitalization can cause impairments detrimental to children with cancer who endure many side effects of therapy. Little is known about how these children mobilize while admitted to the hospital. The purpose of this study was to examine how children admitted to a hematology/oncology ward are mobilizing and analyze factors associated with delayed or infrequent mobility...
April 14, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28407835/-recurrent-pulmonary-infection-and-oral-mucosal-ulcer
#18
Fei-Mei Kuang, Lan-Lan Tang, Hui Zhang, Min Xie, Ming-Hua Yang, Liang-Chun Yang, Yan Yu, Li-Zhi Cao
An 8-year-old girl who had experienced intermittent cough and fever over a 3 year period, was admitted after experiencing a recurrence for one month. One year ago the patient experienced a recurrent oral mucosal ulcer. Physical examination showed vitiligo in the skin of the upper right back. Routine blood tests and immune function tests performed in other hospitals had shown normal results. Multiple lung CT scans showed pulmonary infection. The patient had recurrent fever and cough and persistent presence of some lesions after anti-infective therapy...
April 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28403046/bacterial-osteomyelitis-or-nonbacterial-osteitis-in-children-a-study-involving-the-german-surveillance-unit-for-rare-diseases-in-childhood
#19
MULTICENTER STUDY
Veit Grote, Colen C G Silier, Agnes M Voit, Annette F Jansson
BACKGROUND: Although bacterial osteomyelitis (BO) is a commonly recognized diagnosis in pediatrics, it is often difficult to distinguish from nonbacterial osteitis (NBO). The goal of our study was to distinguish between the 2 disease entities and better define NBO. METHODS: Using the German Surveillance Unit for Rare Diseases in Childhood (Erhebungseinheit für Seltene Paediatrische Erkrankungen in Deutschland), this prospective study during a 5-year period captured 657 patients at first diagnosis of either BO (n = 378) or NBO (n = 279) while analyzing epidemiologic, clinical and radiologic data...
May 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28398680/cytomegalovirus-infection-in-pregnancy
#20
REVIEW
Nicole L Davis, Caroline C King, Athena P Kourtis
Cytomegalovirus (CMV) is a DNA herpesvirus that is common worldwide. The two known main sources of primary CMV infection during pregnancy are through sexual activity and contact with young children. Primary infection occurs in approximately 1 to 4% of pregnancies, and is mostly asymptomatic in immunocompetent adults. However, primary infection may manifest as a mild mononucleosis or flu-like syndrome with persistent fever and fatigue. CMV can be transmitted from mother-to-child in utero, intrapartum, or during breastfeeding...
March 15, 2017: Birth Defects Res
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