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Kazunari Sasaki, Georgios A Margonis, Nikolaos Andreatos, Fabio Bagante, Matthew Weiss, Carlotta Barbon, Irinel Popescu, Hugo P Marques, Luca Aldrighetti, Shishir K Maithel, Carlo Pulitano, Todd W Bauer, Feng Shen, George A Poultsides, Oliver Soubrane, Guillaume Martel, B Groot Koerkamp, Alfredo Guglielmi, Endo Itaru, Federico N Aucejo, Timothy M Pawlik
BACKGROUND: Accurate prediction of prognosis for patients with intrahepatic cholangiocarcinoma (ICC) remains a challenge. We sought to define a preoperative risk tool to predict long-term survival after resection of ICC. STUDY DESIGN: Patients who underwent hepatectomy for ICC at 1 of 16 major hepatobiliary centers between 1990 and 2015 were identified. Clinicopathologic data were analyzed and a prognostic model was developed based on the regression β-coefficients on data in training set...
April 2018: Journal of the American College of Surgeons
Ioannis Kyriazanos, Nikolaos Kopanakis, Vasileios Kalles, Alexios Tzivanakis, Georgios Nikolaou, Elias Efstathiou, John Spiliotis
PURPOSE: The combination of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has been used as locoregional treatment in selected patients with peritoneal malignancy. The purpose of this study was to report on the outcomes of patients undergoing hepatobiliary and pancreatic procedures during CRS and HIPEC. METHODS: A prospectively maintained database was used to identify patients that underwent hepatobilliary and/or pancreatic procedures during CRS and HIPEC...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Geng-Ying Li, Daria D Vaulina, Jia-Je Li, Olga S Fedorova, Hsin-Ell Wang, Ren-Shyan Liu, Raisa N Krasikova, Chuan-Lin Chen
Given the ever-present demand for improved PET radiotracer in oncology imaging, we have synthesized 2-(3,4-dimethoxyphenyl)-6-(2-[18 F]fluoroethoxy)benzothiazole ([18 F]FEDBT), a fluorine-18-containing fluoroethylated benzothiazole to explore its utility as a PET imaging tracer. [18 F]FEDBT was prepared via kryptofix-mediated nucleophilic substitution of the tosyl group precursor. Fractionated ethanol-based solid-phase (SPE cartridge-based) purification afforded [18 F]FEDBT in 60% radiochemical yield (EOB), with radiochemical purity in excess of 98% and the specific activity was 35GBq/μmol...
August 1, 2017: Bioorganic & Medicinal Chemistry Letters
Alexandros Papalampros, Demetrios Moris, Mohammad Fard-Aghaie, Gregor A Stavrou, Evangelos Felekouras, Klaus Niehaus, Karl Oldhafer
PURPOSE: Pancreatic surgery is still thought as a challenging field even for experienced hepatobilliary (HPB) surgeons and high volume tertiary centers. The purpose of this study was to present the results (mortality and morbidity) of pancreatic surgery in a high volume center, in operations performed solely by inexperienced surgeons (two 6th year residents and a HPB fellow) under the supervision of expert surgeons on the field. METHODS: Forty-one consecutive patients who underwent curative-intent pancreatic resection with a modified pancreaticojejunostomy between January 2010 and December 2014 at Asklepios Hospital Barmbek, Germany, were identified from our institutional computer-based database...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Armin Ahmed, Afzal Azim, Mohan Gurjar, Arvind Kumar Baronia
No abstract text is available yet for this article.
September 2014: Indian Journal of Critical Care Medicine
Krishan Kant Agarwal, Sellam Karunanithi, Kalpa Jyothi Das, Sachin Jain, Rakesh Kumar
No abstract text is available yet for this article.
July 2014: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Neha Rathor, Vikas Khillan, S K Sarin
BACKGROUND: Nosocomial urinary tract infections (UTIs) are common in catheterized patients. Fungal UTI has become an important nosocomial problem over the past decade. The microbiology of candiduria is rapidly evolving and new trends are being reported. AIMS: To study the microbiological trends and antifungal resistance profile of Candida in urine of catheterized chronic liver disease (CLD) patients at a super specialty hepatobiliary tertiary-care center. MATERIALS AND METHODS: urine samples were collected by sterile technique, processed by semi-quantitative method as per the standard protocols...
April 2014: Indian Journal of Critical Care Medicine
Jung Hyu Shin, Chang Woo Lee, Soo Jin Oh, Jieun Yun, Moo Rim Kang, Sang-Bae Han, Heungsik Park, Jae Chul Jung, Yoon Hoo Chung, Jong Soon Kang
In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine...
March 2014: Toxicological Research
Tatiana Tăranu, St Toader, Irina Eşanu, Mihaela Paula Toader
Generalized pruritus is a common symptom in elderly, patients, with severe impact on the quality of life. The diagnosis of senile idiopathic pruritus is made after the exclusion of a systemic disease such as chronic renal disease, hepatobilliary disease with cholestasis, thyroid dysfunctions, drug-induced hypersensitivity reactions, visceral or hematological neoplasia, and primitive dermatological distinct conditions. The pathophysiological mechanisms are still unclear. A critical role is considered to be played by changes related to skin aging, cutaneous nerve supply and other nervous system components...
January 2014: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
Zhifei Wang, Quanda Liu, Junzhou Chen, Weihong Duan, Ningxin Zhou
BACKGROUND: Since the introduction of Da Vinci robotic surgery, more and more complicated surgeries can now be performed robotically, yet there have been very few on robotic hepatectomy, especially when billiary reconstruction is involved. The video shows our initial experience with an anatomic hepatectomy using Da Vinci surgical robot. In this case, we also conducted billiary reconstruction due to the anatomic abnormality of bile duct, while applying the choledochoscopy. The preoperative diagnosis is primary liver carcinoma, tumor thrombi in bile duct, and hepatitis B...
June 2013: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Jeany Borges e Silva Ribeiro, Fabrício de Sousa Martins, José Huygens Parente Garcia, Adriano César Costa Cunha, Ricardo Augusto Rocha Pinto, Marcus Vallerius Satacaso, Francisco Paulo Ponte Prado-Júnior, Ricardo Rangel de Paula Pessoa
BACKGROUND: Liver transplantation is the only effective treatment for chronic liver diseases and terminal survival rate has increased in recent decades. However, biliary complications have high incidence and remain as the "Achilles heel" for liver transplantation. AIM: To evaluate retrospectively endoscopic treatment outcomes of biliary complications in post-liver transplantations. METHODS: The sample consisted of post-liver transplantation patients for endoscopic retrograde cholangiopancreatography due to suspected biliary complications...
October 2012: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
E S Golovanova, O G Tolmacheva, O A Maklakova, A N Rumiantseva, A I Aminova
303 children with the diagnosis "Hepatobiliary disorders of cystic duct or gall bladder" and "Sphincter Oddu's spasm" have been examined. After a profound children's examination, the data of objective survey, and also laboratory, biochemical, immune, functional rates (such as ultrasound survey, cardiointervalography) and findings of chemical-analytical survey of the toxics rate (such as aroma carbons, phenol, aldehydes, aliphatic alcohols) in biospheres of children's organisms were a nalysed. The evaluation of the effectiveness of children's hepatobilliary disorders'treatment in conditions of the environmentae negative factors' influence...
2012: Experimental & Clinical Gastroenterology
Thakuri Singh, Neeraj Kumar, Sandeep Soni, Harish Rawat, Gaurav Mittal, Ajay K Singh, Aseem Bhatnagar
BACKGROUND: Radiolabeled human Immunoglobulin-G (hIgG) has demonstrated its utility in inflammation and infection imaging. However, the present method of radiolabeling hIgG is time-consuming and complex. OBJECTIVE: To develop a simplified method of radiolabeling hIgG with technetium-99m ((99m)Tc) via a nicotinyl hydrazine derivative ((99m)Tc-HYNIC-hIgG) and its biological evaluation. RESULTS: In vitro and in vivo studies showed that (99m)Tc-hIgG prepared by this method was fairly stable in physiological saline and human serum till 24 h...
October 2012: Journal of Pharmacy & Bioallied Sciences
Christian Eipel, Elena Menschikow, Michael Sigal, Angela Kuhla, Kerstin Abshagen, Brigitte Vollmar
AIMS: Darbepoetin-α (DPO), a long-acting erythropoietin analog, has been shown to protect the liver against cholestatic injury, to exert an antifibrotic effect, and to increase the survival time in a model of common bile duct ligation. Here we evaluate whether these tissue-protective effects are caused by DPO induced regulation of hepatobiliary transporters. MAIN METHODS: C57BL/6J mice underwent common bile duct ligation and were treated with either DPO or physiological saline...
2013: International Journal of Clinical and Experimental Pathology
A M Abrantes, E Serra, C Goncalves, B Oliveiros, M Laranjo, A B Sarmento-Ribeiro, A Rocha-Gonsalves, M F Botelho
INTRODUCTION: Hypoxia is a biochemical condition where reduced oxygen partial pressure at tissue level occurs. This metabolic situation can lead to resistance to radio and chemotherapy. In malignant solid tumours, hypoxia is a common characteristic, having a great impact at biological level, being of tremendous importance for complete understanding of tumour progression. OBJECTIVES: We studied the behavior of 99mTc-HL91 in vivo, using an animal model based on Balb-c nu/nu mice with a xenotransplant of the human colorectal adenocarcinoma cell line, WiDr...
April 2012: Current Radiopharmaceuticals
Farhang Babamahmoodi, Abdolreza Babamahmoodi
Brucellosis is an infectious disease caused by gram-negative bacteria of the genus Brucella. Involvement of the gastrointestinal, hepatobilliary, and skeletal systems has been reported frequently in the literature. Involvement of the nervous system is relatively uncommon and has been reported in only 3%-25% of cases of generalized brucellosis. Guillain-Barré syndrome is a prototypical postinfectious autoimmune disease. We report a case of Guillain-Barré syndrome in a 26-year-old woman as an uncommon presentation of neurobrucellosis...
October 2011: Journal of Global Infectious Diseases
Matthias Bauwens, Marijke De Saint-Hubert, Ellen Devos, Niko Deckers, Chris Reutelingsperger, Luc Mortelmans, Uwe Himmelreich, Felix M Mottaghy, Alfons Verbruggen
PURPOSE: Two variants of Annexin A5 (Cys2-AnxA5 and Cys165-AnxA5) were labelled with Gallium-68 in order to evaluate their biological properties. PROCEDURES: Biodistribution and pharmacokinetics of the radiotracers were studied with μPET in healthy mice and in a mouse model of hepatic apoptosis. μPET imaging after IV injection of the tracers in combination with μMRI was performed in Daudi tumor bearing mice before and after treatment with a combination of chemotherapy and radiotherapy...
April 2011: Nuclear Medicine and Biology
Sungmin Baek, Yong-Whan Lee, Sik Yoon, Sun-Yong Baek, Bong-Seon Kim, Sae-Ock Oh
Intrahepatic cholangiocarcinoma is the second most common subtype of primary hepatobilliary cancer. Despite advances in surgical and medical therapy, its survival rate remains poor. Compared to hepatocellular carcinoma (HCC), the most common liver malignancy, the underlying mechanisms of cholangiocarcinoma carcinogenesis are poorly characterized. P-cadherin (CDH3) is a cadherin super family member. Although CDH3 is frequently over-expressed in cholangiocarcinoma tissues, its roles have never been characterized...
June 2010: Anatomy & Cell Biology
Shafqut Ali, Samia Iram
BACKGROUND: Hepatitis C is major emerging challenge for pathologists and treating physicians all over the world. Already 10 million Pakistani population has become anti-HCV positive. It is not only affecting hepatobiliary system but with passage of time research is revealing that Hepatitis C is going to involve almost every organ of the body. With timely diagnosis and treatment, millions of patients can be saved from morbidity and mortality. The nation has to sacrifice initial economic allocations to avoid later millions of mortalities and greater economic losses on affected patients and to support their families...
October 2009: Journal of Ayub Medical College, Abbottabad: JAMC
Mariano de la Figuera von Wichmann
No abstract text is available yet for this article.
November 1, 2008: Medicina Clínica
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