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Pneumonia in childrens

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https://www.readbyqxmd.com/read/29688138/antibody-responses-against-streptococcus-pneumoniae-haemophilus-influenzae-and-moraxella-catarrhalis-in-children-with-acute-respiratory-infection-with-or-without-nasopharyngeal-bacterial-carriage
#1
Dafne C Andrade, Igor C Borges, Maiara L Bouzas, Juliana R Oliveira, Helena Käyhty, Olli Ruuskanen, Cristiana Nascimento-Carvalho
BACKGROUND: We studied Immunoglobulin G (IgG) antibody responses against Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis in young children with acute viral type respiratory infection and analyzed the findings in a multivariate model including age, nasopharyngeal carriage of the tested bacteria and pneumococcal vaccination. METHODS: We included 227 children aged 6-23 months with acute respiratory infection. Nasopharyngeal aspirates were tested for bacterial carriage through detection of messenger RNA (mRNA) transcript with nCounter analysis...
April 24, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29685595/invasive-pneumococcal-disease-in-northern-alberta-not-a-red-queen-but-a-dark-horse
#2
Thomas J Marrie, Gregory J Tyrrell, Sumit R Majumdar, Dean T Eurich
BACKGROUND: The consequences of the introduction of various pneumococcal protein conjugate vaccines (PCV) for children and adults is poorly understood. OBJECTIVE: We undertook a population-based cohort study of invasive pneumococcal disease (IPD) in Northern Alberta (Canada) from 2000 to 2014, years spanning pre-and early PCV (2000-2004) vs PCV-7 (2005-2009) vs PCV-13 (2010-2014) time periods. DESIGN: We collected clinical, laboratory, and Streptococcus pneumoniae serotype information on all patients from 2000 to 2014...
April 20, 2018: Vaccine
https://www.readbyqxmd.com/read/29681942/bacterial-profile-antibacterial-resistance-pattern-and-associated-factors-from-women-attending-postnatal-health-service-at-university-of-gondar-teaching-hospital-northwest-ethiopia
#3
Abebaw Bitew Kifilie, Mulat Dagnew, Birhanemeskel Tegenie, Biruk Yeshitela, Rawleigh Howe, Ebba Abate
Introduction: Surgical site infection is a vital cause of maternal mortality and morbidity, especially in resource-limited countries. The rise of antibiotic resistance bacterial infection poses a big threat to this vulnerable population. However, there is lack of studies around the study area. Objective: The purpose of this study was to identify bacterial profile, antibacterial resistance pattern, and associated factors among mothers attending postnatal care health service...
2018: International Journal of Microbiology
https://www.readbyqxmd.com/read/29676360/detection-of-immunoglobulin-m-and-immunoglobulin-g-antibodies-to-mycoplasma-pneumoniae-in-children-with-community-acquired-lower-respiratory-tract-infections
#4
Surinder Kumar, Indu Bala Garg, Gulshan Rai Sethi, Sanchit Kumar, Sanjeev R Saigal
Context: Mycoplasma pneumoniae (M. pneumoniae) causes up to 40% of community-acquired pneumonia in children. It is impossible to identify M. pneumoniae infection on the basis of clinical signs, symptoms, and radiological features. Therefore, correct etiological diagnosis strongly depends on laboratory diagnosis. Aims: This study aims to investigate the role of M. pneumonia e in pediatric lower respiratory tract infections (LRTIs) employing enzyme-linked immunosorbent assays (ELISA) and particle agglutination (PA) test...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29675400/simultaneous-detection-of-key-bacterial-pathogens-related-to-pneumonia-and-meningitis-using-multiplex-pcr-coupled-with-mass-spectrometry
#5
Chi Zhang, Leshan Xiu, Yan Xiao, Zhengde Xie, Lili Ren, Junping Peng
Pneumonia and meningitis continue to present an enormous public health burden and pose a major threat to young children. Among the causative organisms of pneumonia and meningitis, bacteria are the most common causes of serious disease and deaths. It is challenging to accurately and rapidly identify these agents. To solve this problem, we developed and validated a 12-plex PCR coupled with matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) method (bacterial pathogen-mass spectrometry, BP-MS) that can be used to simultaneously screen for 11 key bacterial pathogens related to pneumonia and meningitis...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29673446/a-cross-sectional-survey-assessing-carriage-of-streptococcus-pneumoniae-in-a-healthy-population-in-xinjiang-uygur-autonomous-region-of-china
#6
Na Xie, Zhao Yun Chen, Tao Chen, Bing Qing Zhu, Li Xu, Yuan Gao, Ai Yu Zhang, Pan Zhao, Ji Wen Liu, Zhu Jun Shao
The carriage rate and serotype distribution of Streptococcus pneumoniae (S. pneumoniae) in a healthy population in China remains unclear. In this study, we collected the oropharyngeal swabs from 513 individuals in Xinjiang, China. Real-time PCR targeting the lytA gene and 12 serotypes were assessed to identify S. pneumoniae carriage. The total carriage rate of S. pneumoniae was 70.4% (361/513). The most prevalent serotypes were 19B/F, 18B/C, 5, and 6A/B. The highest carriage rate of S. pneumoniae was noted in children aged 6-10 years (88...
March 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29672858/neonates-colonized-with-pathogenic-bacteria-in-the-airways-have-a-low-grade-systemic-inflammation
#7
Nadia Rahman Fink, Bo Lund Chawes, Jonathan Thorsen, Jakob Stokholm, Karen Krogfelt, Susanne Schjørring, Marie Kragh, Klaus Bønnelykke, Susanne Brix, Hans Bisgaard
BACKGROUND AND OBJECTIVES: The development of childhood asthma is associated with neonatal colonization with pathogenic bacteria in hypopharynx. Furthermore, established asthma is associated with systemic low-grade inflammation. We here report on the association between neonatal colonization with pathogenic bacteria in hypopharynx and the development of systemic low-grade inflammation. METHODS: Bacterial colonization of the hypopharynx with M. catharralis, H. influenzae and/or S...
April 19, 2018: Allergy
https://www.readbyqxmd.com/read/29668816/compliance-with-the-vaccination-schedule-in-children-hospitalized-with-pneumonia-and-associated-factors
#8
Amanda Tabosa Pereira da Silva, Eduardo Jorge da Fonseca Lima, Maria de Fátima Costa Caminha, Andresa Tabosa Pereira da Silva, Edil de Albuquerque Rodrigues Filho, Carmina Silva Dos Santos
OBJECTIVE: To verify the adequacy and factors associated with compliance with the immunization schedule (BCG, DTP-Hib, MMR, PCV-10) in children hospitalized with pneumonia at a pediatric referral hospital in Northeast Brazil. METHODS: This is a cross-sectional, descriptive study with an analytical component, with a sample of 452 children hospitalized with pneumonia at the Instituto de Medicina Integral Prof. Fernando Figueira, between 2010 and 2013. The inclusion criterion was children aged from one month to less than five years of age with proof in the immunization record...
2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29664951/universal-versus-conditional-day-3-follow-up-for-children-with-non-severe-unclassified-fever-at-the-community-level-in-the-democratic-republic-of-the-congo-a-cluster-randomized-community-based-non-inferiority-trial
#9
Luke C Mullany, Elburg W van Boetzelaer, Julie R Gutman, Laura C Steinhardt, Pascal Ngoy, Yolanda Barbera Lainez, Alison Wittcoff, Steven A Harvey, Lara S Ho
BACKGROUND: The World Health Organization's integrated community case management (iCCM) guidelines recommend that all children presenting with uncomplicated fever and no danger signs return for follow-up on day 3 following the initial consultation on day 1. Such fevers often resolve rapidly, however, and previous studies suggest that expectant home care for uncomplicated fever can be safely recommended. We aimed to determine if a conditional follow-up visit was non-inferior to a universal follow-up visit for these children...
April 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29664899/universal-versus-conditional-day-3-follow-up-for-children-with-non-severe-unclassified-fever-at-the-community-level-in-ethiopia-a-cluster-randomised-non-inferiority-trial
#10
Karin Källander, Tobias Alfvén, Tjede Funk, Ayalkibet Abebe, Abreham Hailemariam, Dawit Getachew, Max Petzold, Laura C Steinhardt, Julie R Gutman
BACKGROUND: With declining malaria prevalence and improved use of malaria diagnostic tests, an increasing proportion of children seen by community health workers (CHWs) have unclassified fever. Current community management guidelines by WHO advise that children seen with non-severe unclassified fever (on day 1) should return to CHWs on day 3 for reassessment. We compared the safety of conditional follow-up reassessment only in cases where symptoms do not resolve with universal follow-up on day 3...
April 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29664370/antimicrobial-resistance-in-invasive-bacterial-infections-in-hospitalized-children-cambodia-2007-2016
#11
Andrew Fox-Lewis, Junko Takata, Thyl Miliya, Yoel Lubell, Sona Soeng, Poda Sar, Kolthida Rith, Gregor McKellar, Vanaporn Wuthiekanun, Erin McGonagle, Nicole Stoesser, Catrin E Moore, Christopher M Parry, Claudia Turner, Nicholas P J Day, Ben S Cooper, Paul Turner
To determine trends, mortality rates, and costs of antimicrobial resistance in invasive bacterial infections in hospitalized children, we analyzed data from Angkor Hospital for Children, Siem Reap, Cambodia, for 2007-2016. A total of 39,050 cultures yielded 1,341 target pathogens. Resistance rates were high; 82% each of Escherichia coli and Klebsiella pneumoniae isolates were multidrug resistant. Hospital-acquired isolates were more often resistant than community-acquired isolates; resistance trends over time were heterogeneous...
May 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29663903/burden-of-influenza-in-less-than-5-year-old-children-admitted-to-hospital-with-pneumonia-in-developing-and-emerging-countries-a-descriptive-multicenter-study
#12
Cédric Dananché, Valentina Sánchez Picot, Thomas Bénet, Mélina Messaoudi, Monidarin Chou, Jianwei Wang, Jean-William Pape, Shally Awasthi, Ashish Bavdekar, Mala Rakoto-Andrianarivelo, Mariam Sylla, Pagbajabyn Nymadawa, Graciela Russomando, Florence Komurian-Pradel, Hubert Endtz, Gláucia Paranhos-Baccalà, Philippe Vanhems, On Behalf Of The Pneumonia Gabriel Network
This descriptive 4-year study reports the proportion of detection of influenza viruses in less than 5-year-old children hospitalized for pneumonia in eight developing and emerging countries and describes clinical and microbiological characteristics of influenza-related pneumonia cases. Hospitalized children presenting radiologically confirmed pneumonia aged 2-60 months were prospectively enrolled in this observational standardized study. Mean proportion of isolated influenza virus was 9.7% (95% confidence interval: 7...
April 16, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29662688/distribution-and-determinants-of-pneumonia-diagnosis-using-integrated-management-of-childhood-illness-guidelines-a-nationally-representative-study-in-malawi
#13
Omolara T Uwemedimo, Todd P Lewis, Elsie A Essien, Grace J Chan, Humphreys Nsona, Margaret E Kruk, Hannah H Leslie
Background: Pneumonia remains the leading cause of child mortality in sub-Saharan Africa. The Integrated Management of Childhood Illness (IMCI) strategy was developed to standardise care in low-income and middle-income countries for major childhood illnesses and can effectively improve healthcare worker performance. Suboptimal clinical evaluation can result in missed diagnoses and excess morbidity and mortality. We estimate the sensitivity of pneumonia diagnosis and investigate its determinants among children in Malawi...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29661585/effectiveness-of-influenza-vaccination-for-children-in-japan-four-year-observational-study-using-a-large-scale-claims-database
#14
Natsumi Shibata, Shinya Kimura, Takahiro Hoshino, Masato Takeuchi, Hisashi Urushihara
BACKGROUND: To date, few large-scale comparative effectiveness studies of influenza vaccination have been conducted in Japan, since marketing authorization for influenza vaccines in Japan has been granted based only on the results of seroconversion and safety in small-sized populations in clinical trial phases not on the vaccine effectiveness. We evaluated the clinical effectiveness of influenza vaccination for children aged 1-15 years in Japan throughout four influenza seasons from 2010 to 2014 in the real world setting...
April 13, 2018: Vaccine
https://www.readbyqxmd.com/read/29660749/antimicrobial-peptidomimetics-for-recurrent-septicemia-infections-in-vitro-study-for-immuno-compromised-disease-target
#15
Priyanka Sharma, Kandasamy Nagarajan, Bihu Prasad Panda
The frequency of Bacillus subtilis infection such as pneumonia pan-opthalmitis, visceral abscess or musculoskeletal infection etc. complications following bacteremia, meningitis in children & the infection associated with majority of motor vehicle accidents associated with trauma & gun shoot injury. Antibiotics which appear especially useful in the treatment of Bacillus. infection are clindamycin and vancomycin to which vast majority of strains are susceptible in vitro. Our objective is to test the synthesized peptidomimetics with the efforts mainly directed towards the identification of antibacterial compounds against recurrent septicemia infection...
April 16, 2018: Drug Research
https://www.readbyqxmd.com/read/29660106/safety-effectiveness-and-feasibility-of-outpatient-management-of-children-with-pneumonia-with-chest-indrawing-at-port-moresby-general-hospital-papua-new-guinea
#16
Rose Morre, Kone Sobi, Wendy Pameh, Paulus Ripa, John D Vince, Trevor Duke
Implementing the World Health Organization (WHO) recommendations on home-based management of pneumonia with chest indrawing is challenging in many settings. In Papua New Guinea, 120 children presenting with the WHO definition of pneumonia were screened for danger signs, comorbidities and hypoxaemia using pulse oximetry; 117 were appropriate for home care. We taught mothers about danger signs and when to return, using structured teaching materials and a video. The children were given a single dose of intramuscular benzylpenicillin, then sent home on oral amoxicillin for 5 days, with follow-up at Days 2 and 6...
April 6, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29658455/-efficacy-of-early-treatment-via-fiber-bronchoscope-in-children-with-mycoplasma-pneumoniae-pneumonia-complicated-by-airway-mucus-obstruction
#17
Li-Jie Cao, Jian-Hua Liu, Jin-Feng Shuai, Bo Niu, Su-Kun Lu, Kun-Ling Huang
OBJECTIVE: To study the efficacy of early treatment via fiber bronchoscope in children with Mycoplasma pneumoniae pneumonia (MPP) complicated by airway mucus obstruction. METHODS: According to the time from admission to the treatment via fiber bronchoscope, the children with MPP who were found to have airway mucus obstruction under a fiber bronchoscope were randomly divided into early intervention group (≤3 days; n=40) and late intervention group (>3 days; n=56)...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29658403/endobronchial-stenting-on-vv-ecmo-in-a-6-month-old-girl-with-right-lung-agenesis-and-severe-stenosis-of-the-left-main-bronchus
#18
Vaclav Vobruba, Jiri Votruba, Jan Bělohlávek, Tomas Grus, Pavel Leden, Tomas Zaoral, Jan Hřídel
INTRODUCTION: Lung agenesis is a rare disorder with a variable, but potentially very bad clinical course. It necessitates complex clinical management, especially in life-threatening situations. CASE REPORT: We describe a case of a 6-month-old girl with right lung agenesis who required venovenous extracorporeal membrane oxygenation (VV-ECMO) due to pneumonia complicated by exacerbated previously diagnosed left main bronchus stenosis. The stenosis was resolved by endobronchial intervention and X-ray-guided stent insertion, which enabled weaning from ECMO and was aimed at preventing such a life-threatening respiratory failure in the future...
April 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29658199/the-added-value-of-the-lateral-chest-radiograph-for-diagnosing-community-acquired-pneumonia-in-the-pediatric-emergency-department
#19
Michalle Soudack, Semion Plotkin, Aviva Ben-Shlush, Lisa Raviv-Zilka, Jeffrey M Jacobson, Michael Benacon, Arie Augarten
BACKGROUND: Opinions differ as to the need of a lateral radiograph for diagnosing community acquired pneumonia in children referred to the emergency department. A lateral radiograph increases the ionizing radiation burden but at the same time may improve specificity and sensitivity in this population. OBJECTIVES: To determine the value of the frontal and lateral chest radiographs compared to frontal view stand-alone images for the management of children with suspected community acquired pneumonia seen in a pediatric emergency department...
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29655382/risk-factors-for-influenza-related-complications-in-children-during-the-2009-10-pandemic-a-uk-primary-care-cohort-study-using-linked-routinely-collected-data
#20
J J Lee, C Bankhead, M Smith, A A Kousoulis, C C Butler, K Wang
Primary care clinicians have a central role in managing influenza/influenza-like illness (ILI) during influenza pandemics. This study identifies risk factors for influenza-related complications in children presenting with influenza/ILI in primary care. We conducted a cohort study using routinely collected linked data from the Clinical Practice Research Datalink on children aged 17 years and younger who presented with influenza/ILI during the 2009/10 pandemic. We calculated odds ratios (ORs) for potential risk factors in relation to influenza-related complications, complications requiring intervention, pneumonia, all-cause hospitalisation and hospitalisation due to influenza-related complications within 30 days of presentation...
April 15, 2018: Epidemiology and Infection
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