keyword
MENU ▼
Read by QxMD icon Read
search

cytomegalovirus in pregnancy

keyword
https://www.readbyqxmd.com/read/29132070/sixteen-year-history-of-rituximab-therapy-for-1085-pemphigus-vulgaris-patients-a-systematic-review
#1
REVIEW
Soheil Tavakolpour, HamidReza Mahmoudi, Kamran Balighi, Robabeh Abedini, Maryam Daneshpazhooh
Pemphigus vulgaris (PV) is a rare autoimmune disease due to the production of pathogenic autoantibodies directed against desmoglein 1 and 3, usually affecting both skin and mucous membranes. Recently, rituximab, a chimeric IgG1 monoclonal antibody which targets the CD20 molecules have been regarded as a promising treatment for PV. In this study, a systematic review was conducted to conclude on how and which PV patients could benefit from rituximab infusion. Search in PubMed results in 114 relevant studies, which met the criteria...
November 10, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29119569/the-utility-of-fetal-neurosonography-and-brain-mri-in-cases-of-cytomegalovirus-infection-during-pregnancy-a-retrospective-analysis-with-outcome-correlation
#2
Roee Birnbaum, Liat Ben-Sira, Tally Lerman-Sagie, Gustavo Malinger
OBJECTIVE: To analyze ultrasound and MRI results and developmental outcome in cases of maternal primary CMV infection during pregnancy. METHODS: We retrospectively reviewed the results of fetal neurosonography and brain MRI of CMV infected fetuses (Group 1). Cases of maternal infection in which the fetal status was unknown, and subsequently had a negative CMV postnatal urine analysis, were independently analyzed (Group 2). Imaging results were classified as: positive, negative or inconclusive...
November 8, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29112951/phenotype-and-specificity-of-t-cells-in-primary-human-cytomegalovirus-infection-during-pregnancy-il-7rpos-long-term-memory-phenotype-is-associated-with-protection-from-vertical-transmission
#3
Federico Mele, Chiara Fornara, David Jarrossay, Milena Furione, Alessia Arossa, Arsenio Spinillo, Antonio Lanzavecchia, Giuseppe Gerna, Federica Sallusto, Daniele Lilleri
Congenital human cytomegalovirus (HCMV) infection is the major cause of birth defects and a precise definition of the HCMV-specific T-cell response in primary infection may help define reliable correlates of immune protection during pregnancy. In this study, a high throughput method was used to define the frequency of CD4+ and CD8+ T cells specific for four HCMV proteins in the naïve compartment of seronegative subjects and the effector/memory compartments of subjects with primary/remote HCMV infection. The naïve repertoire displayed comparable frequencies of T cells that were reactive with HCMV structural (pp65, gB and the pentamer gHgLpUL128L) and non-structural (IE-1) proteins...
2017: PloS One
https://www.readbyqxmd.com/read/29099873/assessing-zika-virus-replication-and-the-development-of-zika-specific-antibodies-after-a-mid-gestation-viral-challenge-in-guinea-pigs
#4
Craig J Bierle, Claudia Fernández-Alarcón, Nelmary Hernandez-Alvarado, Jason C Zabeli, Bradley C Janus, Dira S Putri, Mark R Schleiss
Primary Zika virus (ZIKV) infections that occur during pregnancy can cause spontaneous abortion and profoundly disrupt fetal development. While the full range of developmental abnormalities associated with congenital Zika syndrome is not yet known, severe cases of the syndrome can present with microcephaly, extensive neurologic and ocular damage, and pronounced joint malformations. Animal models that accurately recapitulate congenital Zika syndrome are urgently needed for vaccine development and for the study of ZIKV pathogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/29072089/hyperimmune-globulin-in-pregnancy-for-the-prevention-of-congenital-cytomegalovirus-disease
#5
Giovanni Nigro
Cytomegalovirus (CMV) is the most common and serious cause of congenital infections in developed countries since it is capable of infecting the fetus after both primary and recurrent maternal infection, and can be spread for years by infected children. Areas covered: Animal and human pregnancy studies about the prevention of congenital CMV infection and disease by CMV-specific hyperimmune globulin (HIG). Commercial HIG is manufactured from the plasma of selected donors with high anti-CMV antibody avidity and titers...
November 6, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29051058/cytomegalovirus-infection-in-pregnant-women-and-its-association-with-bad-obstetric-outcomes-in-northern-india
#6
Tanzeem Fatima, Haris Siddiqui, Sneha Ghildiyal, Manjari Baluni, Dharam Veer Singh, Amreen Zia, T N Dhole
Cytomegalovirus (CMV) infection during pregnancy is far more complex than other infections, due to ability of the virus to be frequently reactivated during the child bearing age and may vertically transmitted to the developing fetus in spite of maternal immunity. Therefore, in the current study we determined the prevalence of CMV infection in pregnant women and tried to identify the role of maternal CMV infection in adverse pregnancy outcomes in Northern India. In this case-control study, 517 pregnant women, out of them 200 in case group and 317 in the control group...
October 16, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29046308/progress-toward-development-of-a-vaccine-against-congenital-cytomegalovirus-infection
#7
Mark R Schleiss, Sallie R Permar, Stanley A Plotkin
A vaccine against congenital human cytomegalovirus (CMV) infection is a major public health priority. Congenital CMV causes substantial long-term morbidity in newborns, particularly sensorineural hearing loss (SNHL), and the public health impact of this infection on maternal and child health is under-recognized. Although progress toward development of a vaccine has been limited by an incomplete understanding of the correlates of protective immunity for the fetus, knowledge about some of the key components of the maternal immune response necessary for preventing trans-placental transmission is accumulating...
October 18, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/29034112/lack-of-association-between-cytomegalovirus-infection-and-hypertensive-disorders-in-pregnancy-a-case-control-study-in-durango-mexico
#8
Cosme Alvarado-Esquivel, Ada A Sandoval-Carrillo, Fernando Vazquez-Alaniz, José M Salas-Pacheco, Jesús Hernández-Tinoco, Luis Francisco Sánchez-Anguiano, Elizabeth Irasema Antuna-Salcido
It is not clear whether infection with cytomegalovirus (CMV) is associated with hypertensive disorders in pregnant women. Through a case-control study design, 146 women suffering from hypertensive disorders in pregnancy (cases) and 146 age-matched normotensive pregnant women (controls) were examined for the presence of anti-CMV IgG and IgM antibodies with enzyme-linked immunoassays. IgM seropositive samples were further assayed by enzyme-linked fluorescent assay (ELFA). Anti-CMV IgG antibodies were found in 138 (94...
September 2017: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/29022925/anti-cytomegalovirus-immunoglobulin-m-titer-for-congenital-infection-in-first-trimester-pregnancy-with-primary-infection-a-multicenter-prospective-cohort-study
#9
K Toriyabe, F Morikawa, T Minematsu, M Ikejiri, S Suga, T Ikeda
OBJECTIVE: We evaluated cytomegalovirus (CMV) immunoglobulin M (IgM) titer in pregnant women with primary infection as a predictive factor for congenital infection. STUDY DESIGN: Maternal CMV antibody screening during the first trimester was conducted prospectively at 16 centers in Japan between September 2013 and 2015. Women with confirmed maternal primary infection underwent testing for fetal congenital infection, and we investigated the positive predictive value of CMV IgM titer levels for congenital infection in women with a low IgG avidity...
October 12, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29020825/the-yield-of-the-prenatal-work-up-in-intrauterine-growth-restriction-and-the-spectrum-of-fetal-abnormalities-detected-postnatally
#10
Rivka Sukenik-Halevy, Adi Katz, Rivka Regev, Ofer Markovitch, Reuven Sharony, Yael Ganor Paz, Tal Biron-Shental
OBJECTIVE: To evaluate the yield of work-up in intrauterine growth restriction (IUGR) pregnancies and their outcomes. MATERIALS AND METHODS: Retrospective data regarding prenatal work-up (serology, genetic testing and imaging), and neonatal outcomes of 198 IUGR pregnancies (estimated fetal weight < 10th percentile) were analyzed. RESULTS: IUGR was isolated in 72. Work-up performed in 158 (80%) cases was positive in 4 (2.5%). No abnormalities were detected in prenatal genetic testing...
October 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29020188/human-cytomegalovirus-specific-memory-cd4-t-cell-response-and-its-correlation-with-virus-transmission-to-the-fetus-in-pregnant-women-with-primary-infection
#11
Chiara Fornara, Irene Cassaniti, Maurizio Zavattoni, Milena Furione, Kodjo M G Adzasehoun, Annalisa De Silvestri, Giuditta Comolli, Fausto Baldanti
Background: Primary human cytomegalovirus (HCMV) infection during pregnancy is the major cause of congenital viral sequelae. The HCMV-specific T-cell response may have a role in the prevention of virus transmission to the fetus. Methods: HCMV-specific memory T cells were investigated in the second month after primary infection onset in 44 pregnant women (15 transmitting the infection to the fetus) and 8 pregnant women with remote infection. Peripheral blood mononuclear cells were stimulated for 12 days with peptide pools of HCMV proteins IE-1, IE-2, and pp65, and subsequently restimulated for 24 hours with the same peptide pools in a cultured enzyme-linked immunospot (ELISPOT) assay...
July 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020153/universal-screening-with-use-of-immunoglobulin-g-avidity-for-congenital-cytomegalovirus-infection
#12
Kenji Tanimura, Shinya Tairaku, Ichiro Morioka, Kana Ozaki, Satoshi Nagamata, Mayumi Morizane, Masashi Deguchi, Yasuhiko Ebina, Toshio Minematsu, Hideto Yamada
Background: The aim of this prospective cohort study was to evaluate the efficacy of maternal screening for congenital cytomegalovirus infection (CCI) using cytomegalovirus (CMV) immunoglobulin G (IgG) and the IgG avidity index (AI). Methods: Pregnant women underwent screening of CMV IgG and AI measurements. IgG-negative women underwent remeasurement of IgG after educational intervention. Women with an AI ≤45% received further examinations, including measurement of CMV IgM...
October 30, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28980148/the-pathogenesis-of-microcephaly-resulting-from-congenital-infections-why-is-my-baby-s-head-so-small
#13
REVIEW
L D Frenkel, F Gomez, F Sabahi
The emergence of Zika-virus-associated congenital microcephaly has engendered renewed interest in the pathogenesis of microcephaly induced by infectious agents. Three of the original "TORCH" agents are associated with an appreciable incidence of congenital microcephaly: cytomegalovirus, rubella virus, and Toxoplasma gondii. The pathology of congenital microcephaly is characterized by neurotropic infectious agents that involve the fetal nervous system, leading to brain destruction with calcifications, microcephaly, sensorineural hearing loss, and ophthalmologic abnormalities...
October 5, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28978246/prevention-and-treatment-of-fetal-cytomegalovirus-infection-with-cytomegalovirus-hyperimmune-globulin-a-multicenter-study-in-madrid
#14
Daniel Blázquez-Gamero, Alberto Galindo Izquierdo, Teresa Del Rosal, Fernando Baquero-Artigao, Nuria Izquierdo Méndez, María Soriano-Ramos, Pablo Rojo Conejo, María Isabel González-Tomé, Antonio García-Burguillo, Noelia Pérez Pérez, Virginia Sánchez, Jose Tomás Ramos-Amador, Maria De la Calle
INTRODUCTION: Cytomegalovirus (CMV) is the leading cause of congenital infection worldwide. Data about the management of CMV infection in pregnant women are scarce, and treatment options are very limited. The aim of the study is to investigate the effectiveness of cytomegalovirus hyperimmune globulin (CMV-HIG) for the prevention and treatment of congenital CMV (cCMV) infection. MATERIALS AND METHODS: A retrospective observational study was conducted in three tertiary hospitals in Madrid...
October 26, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28976995/knowledge-of-congenital-cytomegalovirus-ccmv-among-physical-and-occupational-therapists-in-the-united-states
#15
Kathleen M Muldoon, Amy Armstrong-Heimsoth, Jodi Thomas
Congenital cytomegalovirus (cCMV) infections cause more children to have permanent disabilities than Down Syndrome, Fetal Alcohol Syndrome, Spina Bifida, and pediatric HIV/AIDS combined. The risk of infection during pregnancy can be significantly decreased using universal precautions, such as thorough handwashing and cleansing of surfaces and objects that have come into contact with infected body fluids. Children under 3 years of age are commonly asymptomatic excretors of CMV, with the highest viral loads present in saliva...
2017: PloS One
https://www.readbyqxmd.com/read/28931421/magnitude-of-the-cytomegalovirus-infection-among-pregnant-women-attending-antenatal-clinics-in-the-city-of-mwanza-tanzania
#16
Elieza Chibwe, Mariam M Mirambo, Albert Kihunrwa, Stephen E Mshana
BACKGROUND: Despite, Cytomegalovirus (CMV) infection being associated with a potential risk to the fetus, there is limited data from Tanzania and many other developing countries regarding the epidemiology and the impact of CMV infections. This cross-sectional study was conducted between December 2014 and June 2015 among pregnant women attending antenatal clinics in the city of Mwanza, Tanzania to investigate the magnitude and associated factors of CMV infection. METHODS: The specific CMV IgM and IgG antibodies were detected using indirect enzyme linked immunosorbent assay (ELISA)...
September 20, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28840519/neighborhood-disadvantage-is-associated-with-high-cytomegalovirus-seroprevalence-in-pregnancy
#17
Paul M Lantos, Kate Hoffman, Sallie R Permar, Pearce Jackson, Brenna L Hughes, Amy Kind, Geeta Swamy
BACKGROUND: Cytomegalovirus (CMV) is the most common infectious cause of fetal malformations and childhood hearing loss. CMV is more common among socially disadvantaged groups, and geographically clusters in poor communities. The Area Deprivation Index (ADI) is a neighborhood-level index derived from census data that reflects material disadvantage. METHODS: We performed a geospatial analysis to determine if ADI predicts the local odds of CMV seropositivity. We analyzed a dataset of 3527 women who had been tested for CMV antibodies during pregnancy...
August 24, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28831237/knowledge-of-human-cytomegalovirus-infection-and-prevention-in-pregnant-women-a-baseline-operational-survey
#18
Maria Mazzitelli, Mariella Micieli, Carmela Votino, Federica Visconti, Paola Quaresima, Alessio Strazzulla, Carlo Torti, Fulvio Zullo
Currently, the only efficient way to prevent human Cytomegalovirus (HCMV) infection in pregnancy is primary prophylaxis through hygienic measures. So, we evaluated knowledge of HCMV and its prevention in a group of pregnant women. An anonymous questionnaire with multiple-choice answers was administered to all pregnant women who were followed up at the Obstetrics and Gynecology Unit of "Pugliese-Ciaccio Hospital," a third-level hospital in Catanzaro (Southern Italy), from November 2015 to March 2016. Previously prescribed serology results for HCMV were also evaluated...
2017: Infectious Diseases in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28825766/trends-in-continuity-of-pregnancy-in-women-with-positive-cytomegalovirus-igm-during-the-first-trimester-2008-2009
#19
Ron Beloosesky, Ilana Feldblum, Alon Shrim, Jenny Kertes, Jacob Segal, Rachel Bachar, Yefet Youval
BACKGROUND: Cytomegalovirus (CMV) infection during pregnancy is the most common cause of intrauterine infection, and is a common cause of sensorineural hearing loss and mental retardation. OBJECTIVES: To evaluate trends in amniocentesis and pregnancy outcome in women with suspected cytomegalovirus (CMV) infection during the first trimester. METHODS: All blood tests for CMV immunoglobulin M (IgM) done between 2008 and 2009 on pregnant women who were enrolled in the Maccabi Healthcare Services were retrieved from laboratory database...
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28817184/the-influence-of-cytomegalovirus-on-expression-of-hla-g-and-its-ligand-kir2dl4-by-human-peripheral-blood-leucocyte-subsets
#20
Z Albayati, A Alyami, S Alomar, D Middleton, L Bonnett, S Aleem, B F Flanagan, S E Christmas
HLA-G is a non-classical class I HLA antigen, normally expressed in high levels only on extravillous cytotrophoblast. It has immunosuppressive properties in pregnancy and has also been found to be upregulated on leucocytes in viral infection. In this study, proportions of all leucocyte subsets expressing HLA-G were found to be low in healthy subjects positive or negative for cytomegalovirus (CMV). Significantly greater proportions of CD4+ CD69+ and CD56+ T cells expressed HLA-G compared to other T cells. However, following stimulation with CMV antigens or intact CMV, proportions of CD4+, CD8+, CD69+ and CD56+ T cells, and also B cells expressing HLA-G, were significantly increased in CMV+ subjects...
November 2017: Scandinavian Journal of Immunology
keyword
keyword
66769
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"