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https://www.readbyqxmd.com/read/28546933/correlation-of-neutrophil-lymphocyte-and-platelet-lymphocyte-ratio-with-visual-acuity-and-macular-thickness-in-age-related-macular-degeneration
#1
Elvan Alper Sengul, Ozgur Artunay, Alev Kockar, Ceyda Afacan, Rifat Rasier, Palmet Gun, Nazli Gul Yalcin, Erdal Yuzbasioglu
AIM: To investigate the place of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in the diagnosis of and prognosis for neovascular age-related macular degeneration (AMD). METHODS: One hundred AMD patients and 100 healthy controls were included in the study. Blood samples were obtained from the venous blood, which is used for routine analysis, and these samples were subjected to complete blood count. NLR was defined as the neutrophil count divided by the number of lymphocytes, and PLR was defined as the platelet count divided by the number of lymphocytes...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28532991/estimating-population-density-for-disease-risk-assessment-the-importance-of-understanding-the-area-of-influence-of-traps-using-wild-pigs-as-an-example
#2
Amy J Davis, Bruce Leland, Michael Bodenchuk, Kurt C VerCauteren, Kim M Pepin
Population density is a key driver of disease dynamics in wildlife populations. Accurate disease risk assessment and determination of management impacts on wildlife populations requires an ability to estimate population density alongside management actions. A common management technique for controlling wildlife populations to monitor and mitigate disease transmission risk is trapping (e.g., box traps, corral traps, drop nets). Although abundance can be estimated from trapping actions using a variety of analytical approaches, inference is limited by the spatial extent to which a trap attracts animals on the landscape...
June 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28528742/patterns-of-gun-deaths-across-us-counties-1999-2013
#3
Bindu Kalesan, Sandro Galea
PURPOSE: We examined the socio-demographic distribution of gun deaths across 3143 counties in 50 United States' states to understand the spatial patterns and correlates of high and low gun deaths. METHODS: We used aggregate counts of gun deaths and population in all counties from 1999 to 2013 from the Centers for Disease Control and Prevention's Wide-ranging Online Data for Epidemiologic Research (WONDER). We characterized four levels of gun violence, as distinct levels of gun death rates of relatively safe, unsafe, violent, and extremely violent counties, based on quartiles of 15-year county-specific gun death rates per 100,000 and used negative binomial regression models allowing clustering by state to calculate incidence rate ratios and 95% confidence intervals (95% CIs)...
April 27, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28525644/risk-factors-and-clinical-outcomes-of-breakthrough-yeast-bloodstream-infections-in-patients-with-hematological-malignancies-in-the-era-of-newer-antifungal-agents
#4
Si-Hyun Kim, Jae-Ki Choi, Sung-Yeon Cho, Hyo-Jin Lee, Sun Hee Park, Su-Mi Choi, Dong-Gun Lee, Jung-Hyun Choi, Jin-Hong Yoo, Jong-Wook Lee
Although yeast bloodstream infections (BSIs) are increasingly being reported in patients with hematological malignancies undergoing antifungal therapy, clinical information regarding breakthrough infections is scarce. The aim of this study was to determine the risk factors for and clinical outcomes of breakthrough yeast BSIs in patients with hematological malignancies in the era of newer antifungal agents. Between 2011 and 2014, all consecutive patients with hematological malignancies who developed yeast BSIs were included in a case-control study wherein breakthrough infections (cases) and de novo infections (controls) were compared...
May 19, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28522589/identification-of-cancer-targeted-tropomyosin-inhibitors-and-their-synergy-with-microtubule-drugs
#5
Mark A Currier, Justine R Stehn, Ashleigh Swain, Duo Chen, Jeff Hook, Eleanor Eiffe, Andrew Heaton, David Brown, Brooke Nartker, David W Eaves, Nina Kloss, Herbert Treutlein, Jun Zeng, Irina B Alieva, Vera B Dugina, Edna C Hardeman, Peter W Gunning, Timothy P Cripe
Actin filaments, with their associated tropomyosin polymers, and microtubules are dynamic cytoskeletal systems regulating numerous cell functions. While anti-microtubule drugs are well-established, anti-actin drugs have been more elusive. We previously targeted actin in cancer cells by inhibiting the function of a tropomyosin isoform enriched in cancer cells, Tpm3.1, using a first-in-class compound, TR100. Here, we screened over 200 other anti-tropomyosin analogues for anti-cancer and on-target activity using a series of in vitro cell-based and biochemical assays...
May 18, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28520488/firearm-legislation-and-fatal-police-shootings-in-the-united-states
#6
Aaron J Kivisto, Bradley Ray, Peter L Phalen
OBJECTIVES: To examine whether stricter firearm legislation is associated with rates of fatal police shootings. METHODS: We used a cross-sectional, state-level design to evaluate the effect of state-level firearm legislation on rates of fatal police shootings from January 1, 2015, through October 31, 2016. We measured state-level variation in firearm laws with legislative scorecards from the Brady Center, and for fatal police shootings we used The Counted, an online database maintained by The Guardian...
May 18, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28516339/holding-manufacturers-of-defective-firearms-to-account-does-restricting-liability-lawsuits-violate-the-second-amendment
#7
Neil J Nusbaum
Judicial and statutory developments since 2005 have placed considerable roadblocks in the way of legal efforts against the epidemic of gun violence in the United States. Although the Second Amendment is most often cited by those opposed to gun control, it offers a potential opportunity to be invoked in support of harm minimization.
May 17, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28509378/evaluation-of-the-skin-phototoxicity-and-photosensitivity-of-honeybee-venom
#8
Sang Mi Han, In Phyo Hong, Soon Ok Woo, Se Gun Kim, He Rye Jang, Kwan Kyu Park
OBJECTIVE: Bee (Apis mellifera L.) venom (BV) has been used as a cosmetic ingredient owing to its anti-aging, anti-inflammatory, and antibacterial effects. The aim of this study was to assess the skin safety of BV. METHODS: For this purpose, skin phototoxicity and sensitization tests were conducted in healthy male Hartley guinea pigs. The animals were divided into three groups (n=5) for the phototoxicity test: G1 (negative control), G2 (BV gel treatment), and G3 (positive control)...
May 16, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28502906/anti-inflammatory-effects-of-forsythia-suspensa-in-dextran-sulfate-sodium-induced-colitis
#9
Youn-Hwan Hwang, Dong-Gun Kim, Wei Li, Hye Jin Yang, Nam-Hui Yim, Jin Yeul Ma
ETHNOPHARMACOLOGICAL RELEVANCE: Forsythia suspensa Fructus (FS) is used to treat various inflammatory disorders in traditional Oriental medicine, including gastrointestinal diseases, but its therapeutic potential in ulcerative colitis is unclear. Thus, we investigated any potential therapeutic effects of FS against intestinal inflammation and the bioactive constituents in FS. MATERIALS AND METHODS: After the induction of colitis using 3% dextran sulfate sodium, FS (100mg/kg/day) was administered orally during the experimental period...
May 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28488235/emulating-host-microbiome-ecosystem-of-human-gastrointestinal-tract-in-vitro
#10
Gun-Seok Park, Min Hee Park, Woojung Shin, Connie Zhao, Sameer Sheikh, So Jung Oh, Hyun Jung Kim
The human gut microbiome performs prodigious physiological functions such as production of microbial metabolites, modulation of nutrient digestion and drug metabolism, control of immune system, and prevention of infection. Paradoxically, gut microbiome can also negatively orchestrate the host responses in diseases or chronic disorders, suggesting that the regulated and balanced host-gut microbiome crosstalk is a salient prerequisite in gastrointestinal physiology. To understand the pathophysiological role of host-microbiome crosstalk, it is critical to recreate in vivo relevant models of the host-gut microbiome ecosystem in human...
May 10, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28481962/the-association-between-urban-tree-cover-and-gun-assault-a-case-control-and-casecrossover-study
#11
Michelle C Kondo, Eugenia C South, Charles C Branas, Therese S Richmond, Douglas J Wiebe
Green space and vegetation may play a protective role for urban violence. We investigated whether being near urban tree cover during outdoor activities related to being assaulted with a gun. We conducted GIS-assisted interviews with 10- to 24-year old males in Philadelphia, PA including 135 patients who had been shot with a firearm and 274 community controls, between 2008-2011. Each subject reported a step-by-step mapped account of where and with whom they travelled over a full day from waking until being assaulted or going to bed...
May 6, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28480517/the-clinical-outcomes-of-patients-with-portal-vein-tumor-thrombi-after-living-donor-liver-transplantation
#12
Ho Joong Choi, Dong Goo Kim, Gun Hyung Na, Tae Ho Hong, Si Hyun Bae, Young Kyoung You, Jong Young Choi, Seung Kew Yoon
INTRODUCTION: The purpose of this study was to evaluate the feasibility of living-donor liver transplantation (LDLT) for treatment of patients with hepatocellular carcinoma (HCC) and segmental portal vein tumor thrombi (PVTT) below the second-order branch. PATIENTS AND METHODS: Between January 2005 and December 2015, we retrospectively analyzed 242 patients in a control group (n = 184), a microvascular invasion (MVI) group (n = 24), and a PVTT group (n = 34). To assess the risks associated with PVTT, we evaluated recurrence, the disease-free survival rate (DFS), the overall survival rate (OS), and various other factors based on the characteristics of patients and tumors...
May 8, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28469758/frequent-immediate-knowledge-of-results-enhances-the-increase-of-throwing-velocity-in-overarm-handball-performance
#13
Igor Štirn, Jamie Carruthers, Marko Šibila, Primož Pori
In the present study, the effect of frequent, immediate, augmented feedback on the increase of throwing velocity was investigated. An increase of throwing velocity of a handball set shot when knowledge of results was provided or not provided during training was compared. Fifty female and seventy-three male physical education students were assigned randomly to the experimental or control group. All participants performed two series of ten set shots with maximal effort twice a week for six weeks. The experimental group received information regarding throwing velocity measured by a radar gun immediately after every shot, whereas the control group did not receive any feedback...
February 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28468137/long-term-outcome-of-microautologous-fat-transplantation-to-correct-temporal-depression
#14
Su-Shin Lee, Yu-Hao Huang, Tsung-Yin Lin, Chih-Kang Chou, Hidenobu Takahashi, Chung-Sheng Lai, Sin-Daw Lin, Tsai-Ming Lin
OBJECTIVE: Sunken temporal fossa appears oftentimes in Asians and resembles bad fortune that people wish to change. Numerous techniques and materials have been applied clinically for augmenting the sunken temporal fossa with variable results. The microautologous fat transplantation (MAFT) technique proposed by Lin et al in 2006 has demonstrated favorable results in facial rejuvenation. In the present study, the authors applied the MAFT technique with an innovative instrument in sunken temporal fossa and reported its results...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28457327/an-epidemiologic-overview-of-13%C3%A2-years-of-firearm-hospitalizations-in-pennsylvania
#15
Brian W Gross, Alan D Cook, Cole D Rinehart, Caitlin A Lynch, Eric H Bradburn, Katherine A Bupp, Chet A Morrison, Frederick B Rogers
BACKGROUND: Gun violence is a controversial public health issue plagued by a lack of recent research. We sought to provide a 13-y overview of firearm hospitalizations in Pennsylvania, analyzing trends in mode, intent, and outcome. We hypothesized that no adjusted change in mortality or functional status at discharge (FSD) would be observed for gunshot wound (GSW) victims over the study period. METHODS: All admissions to the Pennsylvania Trauma Outcome Study database from 2003 to 2015 were queried...
April 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28451799/micro-autologous-fat-transplantation-maft-for-forehead-volumizing-and-contouring
#16
C K Chou, S S Lee, T Y Lin, Y H Huang, H Takahashi, C S Lai, S D Lin, T M Lin
BACKGROUND: Frontal fullness in Asians is often considered to indicate one's public popularity and leadership skills. Numerous materials and techniques have been applied clinically to recontour or volumize the frontal area, with variable results. The micro-autologous fat transplantation (MAFT) technique proposed by Lin et al. (2nd academic congress of Taiwan Cosmetic Association Taipei, Taiwan) in 2007 has demonstrated its feasibility in facial rejuvenation. In the present study, we used an innovative instrument to apply the MAFT technique to frontal augmentation with fat grafting and reported the results...
April 27, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28449133/maternal-alcohol-use-during-pregnancy-and-offspring-attention-deficit-hyperactivity-disorder-adhd-a-prospective-sibling-control-study
#17
Espen Moen Eilertsen, Line C Gjerde, Ted Reichborn-Kjennerud, Ragnhild E Ørstavik, Gun Peggy Knudsen, Camilla Stoltenberg, Nikolai Czajkowski, Espen Røysamb, Kenneth S Kendler, Eivind Ystrom
Background: Maternal alcohol use during pregnancy has repeatedly been associated with development of attention-deficit hyperactivity disorder (ADHD) in the offspring. It is, however not known whether this reflects a direct casual intra-uterine effect or a non-causal relationship due to confounding. We used three different approaches to control for measured and unmeasured confounding: statistical adjustment for covariates, negative control comparison against maternal pre-pregnancy alcohol use, and comparison among differentially exposed siblings...
April 24, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28441965/evaluation-of-a-dna-a%C3%AE-42-vaccine-in-adult-rhesus-monkeys-macaca-mulatta-antibody-kinetics-and-immune-profile-after-intradermal-immunization-with-full-length-dna-a%C3%AE-42-trimer
#18
Doris Lambracht-Washington, Min Fu, Pat Frost, Roger N Rosenberg
BACKGROUND: Aggregated amyloid-β peptide 1-42 (Aβ42), derived from the cellular amyloid precursor protein, is one of the pathological hallmarks of Alzheimer's disease (AD). Although active immunization against Aβ42 peptide was successful in AD mouse models and led to removal of plaques and improved memory, a similar clinical trial in humans (Aβ42 peptide immunization with QS-21 adjuvant) was stopped in phase II, when 6% of the treated patients developed encephalitis. Currently ongoing passive immunizations with the injection of preformed monoclonal antibodies against different epitopes within the Aβ1-42 peptide, which do not lead to activation of the immune system, have shown some effects in slowing AD pathology...
April 26, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28421342/selective-retina-therapy-with-automatic-real-time-feedback-controlled-dosimetry-for-chronic-central-serous-chorioretinopathy-in-korean-patients
#19
Young Gun Park, Seungbum Kang, Minhee Kim, Nari Yoo, Young Jung Roh
PURPOSE: To evaluate the safety and efficacy of selective retina therapy (SRT) with real-time feedback-controlled dosimetry (RFD) in the treatment of chronic central serous chorioretinopathy (CSC). METHODS: In this retrospective case series study, 50 eyes of 49 patients with chronic CSC demonstrating focal or diffuse foveal leakages on fundus fluorescein angiography (FFA) were included. Following evaluation of test spots at temporal arcades, SRT (wavelength 527 nm, pulse repetition rate 100 Hz, pulse energy ramp with maximal 15 pulses) with retinal spot diameter of 200 μm was applied to the areas of each leakage observed on fluorescein angiography...
April 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28418944/the-benefit-of-pro-re-nata-antiemetics-provided-with-guideline-consistent-antiemetics-in-delayed-nausea-control
#20
Sun Young Rha, Joohyuk Sohn, Gun Min Kim, Hye Ryun Kim, Jiyeon Lee
BACKGROUND: Delayed nausea after chemotherapy remains a symptom of interest. Clinicians often provide additional and/or pro re nata (p.r.n.) antiemetics with guideline-consistent antiemetics in an attempt to achieve further symptom control. Whether the usage of additional and/or p.r.n. antiemetics provide added benefit remains as a question. OBJECTIVE: The purpose of this study was to determine the benefit of providing additional antiemetics and/or p.r.n. antiemetics with guideline-consistent antiemetics in the control of nausea, functioning, and quality of life (QOL)...
April 17, 2017: Cancer Nursing
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