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https://www.readbyqxmd.com/read/29046771/a-comparison-of-palonosetron-and-dexamethasone-for-postoperative-nausea-and-vomiting-in-orthopedic-patients-receiving-patient-controlled-epidural-analgesia
#1
Byung-Gun Kim, Hyunzu Kim, Hyun-Kyoung Lim, Chunwoo Yang, Sora Oh, Byung-Wook Lee
BACKGROUND: Postoperative nausea and vomiting (PONV) is one of the major concerns after anesthesia and surgery, and it may be more frequent in orthopedic patients receiving patient-controlled epidural analgesia (PCEA). The purpose of this study was to compare the effect of palonosetron and dexamethasone on the prevention of PONV in patients undergoing total joint arthroplasty and receiving PCEA. METHODS: Patients scheduled for total hip or knee arthroplasty under spinal anesthesia/PCEA were randomly allocated to receive either intravenous palonosetron (0...
October 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29038580/a-novel-library-of-arylketones-as-potential-inhibitors-of-%C3%AE-glucosidase-their-design-synthesis-in-vitro-and-in-vivo-studies
#2
Tania Luthra, Rahul Agarwal, Mamidala Estari, Uma Adepally, Subhabrata Sen
α-glucosidase is an essential enzyme located at the brush border of intestines. It is an important therapeutic target for type II diabetes. Herein we have designed a library of novel α-arylketones as inhibitors of α-glucosidase (yeast origin) via scaffold hopping and bioisosteric modification of known inhibitors of α-glucosidase. The design was validated through molecular docking that revealed strong binding interactions of the newly designed compounds against α-glucosidase. A library comprising of 15 compounds was synthesized in a combinatorial fashion, where the advanced amide intermediates were accessed through "shot gun" synthesis...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037026/treatment-outcomes-of-extended-field-radiation-therapy-for-thoracic-superficial-esophageal-cancer
#3
Doo Yeul Lee, Sung Ho Moon, Kwan Ho Cho, Tae Hyun Kim, Moon Soo Kim, Jong Yeul Lee, Yang-Gun Suh
PURPOSE: To evaluate the efficacy and safety of extended-field radiation therapy for patients with thoracic superficial esophageal cancer (SEC). MATERIALS AND METHODS: From May 2007 to October 2016, a total of 24 patients with thoracic SEC (T1a and T1b) who underwent definitive radiotherapy and were analyzed retrospectively. The median total radiotherapy dose was 64 Gy (range, 54 to 66 Gy) in conventional fractionation. All 24 patients received radiotherapy to whole thoracic esophagus and 23 patients received elective nodal irradiation...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29026888/korean-shock-society-septic-shock-registry-a-preliminary-report
#4
Tae Gun Shin, Sung Yeon Hwang, Gu Hyun Kang, Won Young Kim, Seung Mok Ryoo, Kyuseok Kim, You Hwan Jo, Sung Phil Chung, Young Seon Joo, Jin Ho Beom, Sung-Hyuk Choi, Young Hoon Yoon, Woon Yong Kwon, Tae Ho Lim, Kap Su Han, Han Sung Choi, Gil Joon Suh
OBJECTIVE: To evaluate the clinical characteristics, therapeutic interventions, and outcomes of patients with septic shock admitted to the emergency department (ED). METHODS: This study was a preliminary, descriptive analysis of a prospective, multi-center, observational registry of the EDs of 10 hospitals participating in the Korean Shock Society. Patients aged 19 years or older who had a suspected or confirmed infection and evidence of refractory hypotension or hypoperfusion were included...
September 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/28994869/acute-acoustic-trauma-how-to-manage-and-how-to-prevent
#5
Ali Mardassi, Senda Turki, Hajer Mbarek, Amani Hachicha, Sonia Benzarti, Maher Abouda
INTRODUCTION: The consequence of an exposure to intense sounds can be a temporary or permanent hearing loss and even with a rapid therapeutic management, severe sensorineural sequelae may persist. METHODS: the authors report a retrospective study about 64 patients followed for an acute acoustic trauma during a period of 8 years (2006 to 2013). For all the cases, a clinical examination associated to a pure-tone audiometry was conducted. Hearing levels were measured at the frequencies 500, 1000, 2000 and 3000 Hertz...
November 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28988316/interspecies-transmission-of-emotional-information-via-chemosignals-from-humans-to-dogs-canis-lupus-familiaris
#6
Biagio D'Aniello, Gün Refik Semin, Alessandra Alterisio, Massimo Aria, Anna Scandurra
We report a study examining interspecies emotion transfer via body odors (chemosignals). Do human body odors (chemosignals) produced under emotional conditions of happiness and fear provide information that is detectable by pet dogs (Labrador and Golden retrievers)? The odor samples were collected from the axilla of male donors not involved in the main experiment. The experimental setup involved the co-presence of the dog's owner, a stranger and the odor dispenser in a space where the dogs could move freely...
October 7, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28986427/comprehensive-background-check-policy-and-firearm-background-checks-in-three-us-states
#7
Alvaro Castillo-Carniglia, Rose M C Kagawa, Daniel W Webster, Jon S Vernick, Magdalena Cerdá, Garen J Wintemute
BACKGROUND: Comprehensive background check (CBC) policies are hypothesised to reduce firearm-related violence because they extend background checks to private party firearm sales, but no study has determined whether these policies actually increase background checks, an expected intermediary outcome. We evaluate the association between CBC policies and the rates of firearm background checks in three states that recently implemented these policies: Delaware (July 2013), Colorado (July 2013) and Washington (December 2014)...
October 6, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28978480/a-rhoa-fret-biosensor-mouse-for-intravital-imaging-in-normal-tissue-homeostasis-and-disease-contexts
#8
Max Nobis, David Herrmann, Sean C Warren, Shereen Kadir, Wilfred Leung, Monica Killen, Astrid Magenau, David Stevenson, Morghan C Lucas, Nadine Reischmann, Claire Vennin, James R W Conway, Alice Boulghourjian, Anaiis Zaratzian, Andrew M Law, David Gallego-Ortega, Christopher J Ormandy, Stacey N Walters, Shane T Grey, Jacqueline Bailey, Tatyana Chtanova, Julian M W Quinn, Paul A Baldock, Peter I Croucher, Juliane P Schwarz, Agata Mrowinska, Lei Zhang, Herbert Herzog, Andrius Masedunskas, Edna C Hardeman, Peter W Gunning, Gonzalo Del Monte-Nieto, Richard P Harvey, Michael S Samuel, Marina Pajic, Ewan J McGhee, Anna-Karin E Johnsson, Owen J Sansom, Heidi C E Welch, Jennifer P Morton, Douglas Strathdee, Kurt I Anderson, Paul Timpson
The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development. Here, we describe the generation of a RhoA-fluorescence resonance energy transfer (FRET) biosensor mouse and its utility for monitoring real-time activity of RhoA in a variety of native tissues in vivo. We assess changes in RhoA activity during mechanosensing of osteocytes within the bone and during neutrophil migration...
October 3, 2017: Cell Reports
https://www.readbyqxmd.com/read/28976811/after-the-mass-shooting-in-las-vegas-finding-common-ground-on-gun-control
#9
Edward W Campion, Stephen Morrissey, Debra Malina, Chana A Sacks, Jeffrey M Drazen
We’ve seen so many mass shootings — in theaters, in churches, in nightclubs, in schools — that each new episode of the mass slaughter of Americans induces a weary sense of déjà vu. But some realities of the recent mass shooting in Las Vegas, the largest in modern history, might help produce action,..
October 4, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28975877/attitudes-to-gun-control-in-an-american-twin-sample-sex-differences-in-the-causes-of-variation
#10
Lindon J Eaves, Judy L Silberg
The genetic and social causes of individual differences in attitudes to gun control are estimated in a sample of senior male and female twin pairs in the United States. Genetic and environmental parameters were estimated by weighted least squares applied to polychoric correlations for monozygotic (MZ) and dizygotic (DZ) twins of both sexes. The analysis suggests twin similarity for attitudes to gun control in men is entirely genetic while that in women is purely social. Although the volunteer sample is small, the analysis illustrates how the well-tested concepts and methods of genetic epidemiology may be a fertile resource for deepening our scientific understanding of biological and social pathways that affect individual risk to gun violence...
October 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28973535/effects-of-exposure-to-gun-violence-in-movies-on-children-s-interest-in-real-guns
#11
Kelly P Dillon, Brad J Bushman
Importance: More US children die by accidental gun use than children in other developed countries. One factor that can influence children's interest in guns is exposure to media containing guns. Objective: To test whether children who see a movie containing guns will handle a real gun longer and will pull the trigger more times than children who see the same movie not containing guns. Design, Setting, and Participants: One hundred four children aged 8 to 12 years recruited through advertisements were randomly assigned in pairs to watch a 20-minute PG-rated movie containing or not containing guns in a university laboratory...
September 25, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28965411/next-generation-proteomic-pipeline-for-chromosome-based-proteomic-research-using-nextprot-and-gencode-databases
#12
Heeyoun Hwang, Gun Wook Park, Ji Yeong Park, Hyun Kyoung Lee, Ju Yeon Lee, Ji Eun Jeong, Sung-Kyu Robin Park, John R Yates, Kyung-Hoon Kwon, Young Mok Park, Hyoung-Joo Lee, Young-Ki Paik, Jin Young Kim, Jong Shin Yoo
Human Proteome Project aims to map all human proteins including missing proteins as well as proteoforms with post translational modifications, alternative splicing variants (ASVs), and single amino acid variants (SAAVs). neXtProt and Ensemble databases are usually used to provide curated information of human coding genes. However, in order to find these proteoforms, we (Chr #11 team) first introduce a streamlined pipeline using customized and concatenated neXtProt and GENCODE originated from Ensemble, with controlled false discovery rate (FDR)...
October 1, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28940351/when-public-health-becomes-politicized
#13
Barron H Lerner
Perhaps nothing symbolizes the current polarized political climate in the United States more than the world of public health. Public health schools and health departments are full of "true believers," people willing to crusade for any program designed to reduce morbidity and mortality. But in the "real world," proven programs and strategies-such as gun-control measures, universal vaccination, and improved traffic safety-are routinely thwarted. Why do critics oppose efforts to improve the public's health? History can provide some answers...
September 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28939500/impact-of-patient-audio-visual-re-education-through-a-smartphone-on-quality-of-bowel-preparation-before-colonoscopy-a-single-blinded-randomized-study
#14
Su Young Back, Hyun Gun Kim, Eu Mi Ahn, Suyeon Park, Seong Ran Jeon, Hee Hyuk Im, Jin-Oh Kim, Bong Min Ko, Joon Seong Lee, Tae Hee Lee, Jun-Hyung Cho
BACKGROUND AND AIMS: Preparation education is essential for successful colonoscopy. This study aimed to evaluate the impact of audio-visual (AV) re-education through a smartphone before colonoscopy on bowel preparation quality. METHODS: A prospective, endoscopist-blinded, randomized, controlled study was performed. Patients who underwent colonoscopy with 3 purgatives, including 4 L polyethylene glycol (4L-PEG), 2 L PEG with ascorbic acid (2L-PEG/Asc) and sodium picosulfate with magnesium citrate (SPMC), were enrolled, and randomized into AV re-education through smartphone group (AV group, n=160) and a control group (n=160)...
September 19, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28919126/low-dose-ct-for-the-diagnosis-of-appendicitis-in-adolescents-and-young-adults-locat-a-pragmatic-multicentre-randomised-controlled-non-inferiority-trial
#15
(no author information available yet)
BACKGROUND: CT radiation is arguably carcinogenic. Results from single-centre studies, mostly retrospective, have advocated lowering the CT radiation dose for the diagnosis of appendicitis. However, adoption of low-dose CT has been slow. We aimed to assess the effectiveness of low-dose CT compared with standard-dose CT in the diagnosis of appendicitis in adolescents and young adults. METHODS: We did this pragmatic, multicentre, randomised controlled non-inferiority trial at 20 South Korean teaching hospitals with little experience with low-dose CT...
November 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28899989/dipeptidyl-peptidase-4-inhibitors-and-risk-of-heart-failure-in-patients-with-type-2-diabetes-mellitus-a-population-based-cohort-study
#16
COMPARATIVE STUDY
Young-Gun Kim, Dukyong Yoon, Sooyoung Park, Seung Jin Han, Dae Jung Kim, Kwan-Woo Lee, Rae Woong Park, Hae Jin Kim
BACKGROUND: The association between dipeptidyl-peptidase IV inhibitors (DPP-4i) and heart failure (HF) remains unclear. In 1 randomized controlled trial and some observational studies, DPP-4i reportedly increased the risk of HF, but 2 other randomized controlled trials and observational studies have shown no such risk. Here, we evaluated the risk of HF and cardiovascular outcomes of DPP-4i compared with sulfonylureas. METHODS AND RESULTS: A population-based retrospective cohort study was conducted using the Korean Health Insurance Review and Assessment Service database from January 1, 2009, to December 31, 2015...
September 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28888336/pediatric-firearm-deaths-and-injuries-in-the-united-states
#17
Deborah L McBride
Guns are the third leading cause of death of those aged 1 to 17years, outpaced only by unintentional injuries such as car crashes and drowning, and illnesses like cancer according to a new federal study. The new study, which has been called the most comprehensive examination of current firearms-related deaths and injury among children in the United States used data from the National Electronic Injury Surveillance System and the Centers for Disease Control and Prevention (CDC) National Violent Death Reporting System to assess the magnitude and characteristics of firearm-related deaths and injuries among children (age 0-17years) from 2002 to 2014...
September 6, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28863682/determining-the-ion-temperature-and-energy-distribution-in-a-lithium-plasma-interaction-test-stand-with-a-retarding-field-energy-analyzer
#18
M Christenson, S Stemmley, S Jung, J Mettler, X Sang, D Martin, K Kalathiparambil, D N Ruzic
The ThermoElectric-driven Liquid-metal plasma-facing Structures (TELS) experiment at the University of Illinois is a gas-puff driven, theta-pinch plasma source that is used as a test stand for off-normal plasma events incident on materials in the edge and divertor regions of a tokamak. The ion temperatures and resulting energy distributions are crucial for understanding how well a TELS pulse can simulate an extreme event in a larger, magnetic confinement device. A retarding field energy analyzer (RFEA) has been constructed for use with such a transient plasma due to its inexpensive and robust nature...
August 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28861199/the-efficacy-of-vitamin-c-on-postoperative-outcomes-after-posterior-lumbar-interbody-fusion-a-randomized-placebo-controlled-trial
#19
Gun Woo Lee, Han Seok Yang, Jin S Yeom, Myun-Whan Ahn
BACKGROUND: Vitamin C has critical features relavant to postoperative pain management and functional improvement; however, no study has yet evaluated the effectiveness of vitamin C on improving the surgical outcomes for spine pathologies. Thus, this study aimed to explore the impact of vitamin C on postoperative outcomes after single-level posterior lumbar interbody fusion (PLIF) for lumbar spinal stenosis in prospectively randomized design. We conducted a 1-year prospective, randomized, placebo-controlled, double-blind study to evaluate the impact of vitamin C on the postoperative outcomes after PLIF surgery...
September 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28851960/fundamental-and-experimental-aspects-of-diffraction-for-characterizing-dislocations-by-electron-channeling-contrast-imaging-in-scanning-electron-microscope
#20
H Kriaa, A Guitton, N Maloufi
Nowadays Field Emission Gun-Scanning Electron Microscopes provide detailed crystallographic information with high spatial and angular resolutions, and allow direct observation of crystalline defects, such as dislocations, through an attractive technique called Electron Channeling Contrast Imaging (ECCI). Dislocations play a crucial role in the properties of materials and ECCI has naturally emerged as an adapted tool for characterizing defects in bulk specimen. Nevertheless, fine control of the channeling conditions is absolutely required to get strong dislocation contrast for achieving comprehensive analysis...
August 29, 2017: Scientific Reports
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