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https://www.readbyqxmd.com/read/29224217/longitudinal-trajectory-of-the-relationship-between-self-esteem-and-substance-use-from-adolescence-to-young-adulthood
#1
Chung Gun Lee, Dong-Chul Seo, Mohammad R Torabi, David K Lohrmann, Tae Min Song
BACKGROUND: We examined the longitudinal trajectory of substance use (binge drinking, marijuana use, and cocaine use) in relation to self-esteem from adolescence to young adulthood. METHODS: Generalized estimating equation models were fit using SAS to investigate changes in the relation between self-esteem and each substance use (binge drinking, marijuana use, and cocaine use) from adolescence to young adulthood. Data were drawn from the 3 waves of the National Longitudinal Study of Adolescent Health, a nationally representative sample of middle and high school students in the United States (N = 6504)...
January 2018: Journal of School Health
https://www.readbyqxmd.com/read/29206575/gun-attitudes-on-campus-united-and-divided-by-safety-needs
#2
James A Shepperd, Gabrielle Pogge, Joy E Losee, Nikolette P Lipsey, Liz Redford
All people share a need for safety. Yet, people's pursuit of safety can conflict when it comes to guns, where some people perceive guns as a means to safety and others perceive guns as a threat to safety. We examined this conflict on a United States college campus that prohibits guns. We distinguished between people (N = 11,390) who (a) own a gun for protection, (b) own a gun exclusively for reasons other than protection (e.g., collecting, sports), and (c) do not own a gun. Protection owners felt less safe on campus, supported allowing guns on campus, and reported that they and others would feel safer and that gun violence would decrease if they carried a gun on campus...
December 5, 2017: Journal of Social Psychology
https://www.readbyqxmd.com/read/29202658/ambroise-par%C3%A3-1510-1590-and-his-innovative-work-on-the-treatment-of-war-injuries
#3
Konstantinos Markatos, Anna Tzivra, Spyridon Tsoutsos, Gerasimos Tsourouflis, Marianna Karamanou, Georgios Androutsos
The purpose of this study is to summarize the innovations of Ambroise Paré (1510-1590) on the treatment of war wounds and improving amputation technique through ligature in arteries and veins. Ambroise Paré debunked the widely accepted idea that gun powder was poisonous for wounds. He also minimized the use of cautery of wounds by his dressing methods and the application of ligature during amputations. All these innovative rationales revolutionized the practice of war surgery during the Renaissance and paved the way for the introduction of modern surgery...
December 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/29194736/micrornas-in-orthopaedic-research-disease-associations-potential-therapeutic-applications-and-perspectives
#4
Audrey McAlinden, Gun-Il Im
MicroRNAs (miRNAs) are small non-coding RNAs that function to control many cellular processes by their ability to suppress expression of specific target genes. Tens to hundreds of target genes may be affected by one miRNA, thereby resulting in modulation of multiple pathways in any given cell type. Therefore, altered expression of miRNAs (i.e. during tissue development or in scenarios of disease or cellular stress) can have a profound impact on processes regulating cell differentiation, metabolism, proliferation or apoptosis, for example...
November 30, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29184442/exome-and-transcriptome-sequencing-identifies-loss-of-pdlim2-in-metastatic-colorectal-cancers
#5
Bo Young Oh, Jeonghee Cho, Hye Kyung Hong, Joon Seol Bae, Woong-Yang Park, Je-Gun Joung, Yong Beom Cho
Background: Understanding the genomic determinants associated with metastasis in colorectal cancers (CRCs) provides crucial clues for improving patient care. Patients and methods: In this study, we performed whole-exome sequencing as well as RNA sequencing analyses on five pairs of primary and liver metastasized samples from CRC patients together with blood/normal control samples for each pair. Results: We identified genomic deletions in the region of 8p21-23 (q value <0...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29173444/combined-effects-of-multiple-risk-factors-on-asthma-in-school-aged-children
#6
Sylvia S Szentpetery, Olena Gruzieva, Erick Forno, Yueh-Ying Han, Anna Bergström, Inger Kull, Edna Acosta-Pérez, Angel Colón-Semidey, Maria Alvarez, Glorisa J Canino, Erik Melén, Juan C Celedón
BACKGROUND: Little is known about synergistic effects of several risk factors on asthma. We developed a risk score in Puerto Rican children, and then used this score to estimate the combined effects of multiple risk factors on asthma at school age in Puerto Rican and Swedish children. METHODS: Case-control study in 609 Puerto Rican children (aged 6-14 years) and longitudinal birth cohort study of 2290 Swedish children followed up to age 12 years (The Children, Allergy, Milieu, Stockholm, Epidemiological Survey [BAMSE] Study)...
December 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29172925/parents-experiences-and-responses-to-an-intervention-for-psychological-preparation-of-children-and-families-during-the-child-s-radiotherapy
#7
Charlotte Ångström-Brännström, Viveca Lindh, Tara Mullaney, Kristina Nilsson, Gun Wickart-Johansson, Anna-Maja Svärd, Tufve Nyholm, Jack Lindh, Gunn Engvall
The aim of this study was to evaluate parents' experiences and responses to a systematic intervention for psychological preparation of children and families during the child's radiotherapy (RT) treatment. In this case-control study at 3 pediatric RT centers, an intervention with a preparatory kit, including age-adjusted information on tablets, gift of a stuffed toy or a pair of headphones, a parent booklet, and toy models of the computed tomography and RT machines was implemented. For evaluation, a mixed methods data collection was conducted...
November 1, 2017: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/29172558/childhood-risk-factors-associated-with-adolescent-gun-carrying-among-black-and-white-males-an-examination-of-self-protection-social-influence-and-antisocial-propensity-explanations
#8
Jordan Beardslee, Meagan Docherty, Edward Mulvey, Carol Schubert, Dustin Pardini
Adolescent gun violence is a serious public health issue that disproportionately affects young Black males. Although it has been postulated that differential exposure to childhood risk factors might account for racial differences in adolescent gun carrying, no longitudinal studies have directly examined this issue. We examined whether childhood risk factors indexing neighborhood crime, peer delinquency, and conduct problems predicted the initiation of adolescent gun carrying among a community sample of Black and White boys...
November 27, 2017: Law and Human Behavior
https://www.readbyqxmd.com/read/29158765/usefulness-of-the-korean-developmental-screening-test-for-infants-and-children-for-the-evaluation-of-developmental-delay-in-korean-infants-and-children-a-single-center-study
#9
Chung-Hyuk Yim, Gun-Ha Kim, Baik-Lin Eun
Purpose: To evaluate the usefulness of the Korean Developmental Screening Test (K-DST) for infants and children for developmental delay assessment. Methods: This study was based on retrospective studies of the results of the K-DST, Preschool Receptive-Expressive Language Scale (PRES), Sequenced Language Scale for Infants (SELSI), Childhood Autism Rating Scale (CARS), Modified Checklist for Autism in Toddlers (M-CHAT), electroencephalography, magnetic resonance imaging, and extensive tests conducted in 209 of 1,403 patients, of whom 758 underwent the K-DST at the Korea University Guro Hospital between January 2015 and December 2016 and 645 were referred from local clinics between January 2015 and June 2016...
October 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29153641/a-middle-east-respiratory-syndrome-screening-clinic-for-health-care-personnel-during-the-2015-middle-east-respiratory-syndrome-outbreak-in-south-korea-a-single-center-experience
#10
Ji Yeon Lee, Gayeon Kim, Dong-Gyun Lim, Hyeon-Gun Jee, Yunyoung Jang, Joon-Sung Joh, Ina Jeong, Yeonjae Kim, Eunhee Kim, Bum Sik Chin
BACKGROUND: Transmission of Middle East respiratory syndrome (MERS) to health care personnel (HCP) is a major concern. This study aimed to review cases of MERS-related events, such as development of MERS-like symptoms or exposure to patients. METHODS: A MERS screening clinic (MSC) for HCP was setup in the National Medical Center during the MERS outbreak in 2015. Clinical and laboratory data from HCP who visited the MSC were retrospectively reviewed. Additionally, these data were compared with the results of postoutbreak questionnaire surveys and interviews about MERS-related symptoms and risk-related events...
November 16, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29151718/achievement-of-adequate-glycemic-control-in-patients-with-type-2-diabetes-and-comorbid-mental-health-conditions-treated-in-a-primary-care-setting
#11
Kaitlyn Brown, Katherine Fortenberry, Lisa Gren, Karen Gunning, Carrie McAdam-Marx
Objective: This study investigated the association between the presence of a mental health condition (MHC) diagnosis and glycemic control in patients with type 2 diabetes in a primary care clinic network. Methods: This retrospective cross-sectional study compared adequate glycemic control (A1C <8.0%) in patients with type 2 diabetes with and without any MHC, as well as by MHC subtypes of depression or anxiety, bipolar or schizophrenia disorders, and substance use disorder...
November 2017: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29148847/emerging-therapeutic-targets-in-myeloproliferative-neoplasms-and-peripheral-t-cell-leukemia-and-lymphomas
#12
Anna Orlova, Bettina Wingelhofer, Heidi A Neubauer, Barbara Maurer, Angelika Berger-Becvar, György Miklós Keserű, Patrick T Gunning, Peter Valent, Richard Moriggl
Hematopoietic neoplasms are often driven by gain-of-function mutations of the JAK-STAT pathway together with mutations of chromatin remodeling and DNA damage control pathways. The interconnection between the JAK-STAT pathway, epigenetic regulation or DNA damage control is still poorly understood in cancer cell biology. Areas covered: Here, we focus on a broader description of mutational insights into myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas, since sequencing efforts have identified similar combinations of driver mutations in these diseases covering different lineages...
November 17, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29121706/protective-effect-of-fucoidan-extract-from-ecklonia-cava-on-hydrogen-peroxide-induced-neurotoxicity
#13
Seon Kyeong Park, Jin Yong Kang, Jong Min Kim, Sang Hyun Park, Bong Seok Kwon, Gun-Hee Kim, Ho Jin Heo
We evaluated the antioxidant activity and neuronal cell-protective effect of fucoidan extract from Ecklonia cava (FEC) on hydrogen peroxide (H2O2)-induced cytotoxicity in PC-12 and MC-IXC cells to assess its protective effect against oxidative stress. Antioxidant activities were examined using the ABTS radical scavenging activity and malondialdehyde (MDA)-inhibitory effect, and the results showed that FEC had significant antioxidant activity. Intracellular ROS content and neuronal cell viability were investigated using DCF-DA assay and MTT reduction assay...
November 9, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29121705/reactive-oxygen-species-depletion-by-silibinin-stimulates-apoptosis-like-death-in-escherichia-coli
#14
Bin Lee, Dong Gun Lee
Silibinin is the major active component of silymarin, extracted from medicinal plant Silybum marianum. Silibinin has potent antibacterial activity; however, the exact mechanism underlying its activity has not been elucidated. Here, we investigated the novel mechanism of silibinin against Escherichia coli. Time-kill kinetic assay showed that silibinin possess a bactericidal effect at minimal inhibitory concentration (MIC) and higher concentrations (two and four-fold MIC). At the membrane depolarization and increased intracellular Ca²⁺ levels were observed, considered as characteristics of bacterial apoptosis...
November 9, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29117016/analyzing-the-readability-of-online-urogynecologic-patient-information
#15
J Ryan Stewart, Michael H Heit, Kate V Meriwether, Deslyn T Hobson, Sean L Francis
OBJECTIVE: We sought to describe the readability of Web sites arising from the most common Google search terms related to pelvic organ prolapse, bladder control, and bowel control. METHODS: Google was queried to capture the top 100 search results for the keywords in each disease group. For the top 20 results of each keyword, we analyzed the text for readability using 4 readability formulas: Dale-Chall, Gunning-Fog, Simple Measure of Gobbledygook (SMOG), and Flesch-Kincaid Grade Level...
November 7, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29112125/the-development-of-an-imu-integrated-clothes-for-postural-monitoring-using-conductive-yarn-and-interconnecting-technology
#16
Sung-Won Kang, Hyeob Choi, Hyung-Il Park, Byoung-Gun Choi, Hyobin Im, Dongjun Shin, Young-Giu Jung, Jun-Young Lee, Hong-Won Park, Sukyung Park, Jung-Sim Roh
Spinal disease is a common yet important condition that occurs because of inappropriate posture. Prevention could be achieved by continuous posture monitoring, but most measurement systems cannot be used in daily life due to factors such as burdensome wires and large sensing modules. To improve upon these weaknesses, we developed comfortable "smart wear" for posture measurement using conductive yarn for circuit patterning and a flexible printed circuit board (FPCB) for interconnections. The conductive yarn was made by twisting polyester yarn and metal filaments, and the resistance per unit length was about 0...
November 7, 2017: Sensors
https://www.readbyqxmd.com/read/29111556/mechano-responsive-lateral-buckling-of-miniaturized-beams-standing-on-flexible-substrates
#17
Hyemin Lee, Jung Gun Bae, Won Bo Lee, Hyunsik Yoon
We fabricate an elastomeric beam standing on a flexible substrate using 3D printing and soft lithography and investigate lateral buckling generated in the part of the wall when this beam is under pure bending. We also observe changes in the morphology of wrinkling along the applied strain and geometry of the wall, and then analyze it with scaling concepts. Furthermore, the degree of lateral buckling is controlled through the tip design in the ratchet structure and it is verified with finite element simulation...
November 22, 2017: Soft Matter
https://www.readbyqxmd.com/read/29111132/age-related-repetitive-transcranial-magnetic-stimulation-effects-on-executive-function-in-depression-a-systematic-review
#18
REVIEW
Irena P Ilieva, George S Alexopoulos, Marc J Dubin, S Shizuko Morimoto, Lindsay W Victoria, Faith M Gunning
OBJECTIVE: The aims of the current review were to: 1) examine whether the rTMS effects on executive function increase as age advances; 2) to examine the potential of rTMS to remediate executive function in older depressed patients; and 3) to assess the relationship between the executive function and mood benefits from rTMS in depression. METHODS: Randomized or matched-groups, blind, sham-controlled studies (12 studies, 347 participants) on excitatory rTMS applied to left DLPFC in depression were reviewed...
September 11, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29095748/central-control-of-eye-movements
#19
Jonathan J D Baird-Gunning, Christian J Lueck
PURPOSE OF REVIEW: Eye-movement research continues to provide an excellent tool for understanding the central control of motor function, both in health and disease. This article reviews recent findings in relation to saccadic eye movements, particularly antisaccades and microsaccades, with particular emphasis on the control of inaction, something which has recently become topical. RECENT FINDINGS: Microsaccades are under the control of the cerebral cortex, particularly the frontal and parietal eye fields...
November 1, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29092621/piecing-the-puzzle-together-the-central-role-of-ros-and-redox-hubs-in-chloroplast-retrograde-signaling
#20
Dario Leister
SIGNIFICANCE: Reactive oxygen species (ROS) and redox regulation are established components of chloroplast-nucleus retrograde signaling. Recent Advances: In recent years a complex array of putative retrograde signaling molecules and novel signaling pathways has emerged, including various metabolites, chloroplast translation, mobile transcription factors, calcium and links to the unfolded protein response (UPR). This critical mass of information now permits us to fit individual pieces into a larger picture and outline a few important stimuli and pathways...
November 1, 2017: Antioxidants & Redox Signaling
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