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https://www.readbyqxmd.com/read/28333340/evaluation-of-the-new-genotype-ntm-dr-kit-for-the-molecular-detection-of-antimicrobial-resistance-in-non-tuberculous-mycobacteria
#1
Faiza Mougari, Jade Loiseau, Nicolas Veziris, Christine Bernard, Béatrice Bercot, Wladimir Sougakoff, Vincent Jarlier, Laurent Raskine, Emmanuelle Cambau
Objectives: Non-tuberculous mycobacteria (NTM) are emerging pathogens causing difficult-to-treat infections. We tested a new assay (GenoType NTM-DR) that detects natural and acquired resistance mechanisms to macrolides and aminoglycosides in frequently isolated NTM species. Methods: Performance was assessed on 102 isolates including reference strains [16 Mycobacterium avium , 10 Mycobacterium intracellulare , 8 Mycobacterium chimaera , 15 Mycobacterium chelonae and 53 Mycobacterium abscessus (including subsp...
February 28, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28331949/-nontuberculous-mycobacteria
#2
K Emmerich, M Fabri
Dermatologically relevant nontuberculous mycobacteria (NTM) include Mycobacterium marinum and Mycobacterium ulcerans and different rapidly growing mycobacteria (RGM). RGM are widely present in the environment and are facultative pathogenic. Diagnostic detection of nontuberculous mycobacteria is frequently challenging. Immune-competent individuals mostly develop localized infections. Immune-suppressed patients may present with severe and disseminated disease. In these cases, rapid initiation of medical treatment is important...
March 22, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28331837/public-health-relevance-of-non-tuberculous-mycobacteria-among-afb-positive-sputa
#3
Prabha Desikan, Karuna Tiwari, Nikita Panwalkar, Saima Khaliq, Manju Chourey, Reeta Varathe, Shaina Beg Mirza, Arun Sharma, Sridhar Anand, Manoj Pandey
BACKGROUND: Sputum smear microscopy for acid fast bacilli (AFB) is used by most public health programmes to detect tuberculosis. While most AFB in countries endemic for tuberculosis are Mycobacterium tuberculosis (MTB), some may also be non-tuberculous mycobacteria (NTM). The inability to differentiate NTM from MTB by sputum smear microscopy may lead to erroneous diagnoses of tuberculosis, leading in turn to inappropriate therapy. METHODS: This was a retrospective study of consecutive sputum samples received from November 2013 to March 2015 in the Department of Microbiology, Bhopal Memorial Hospital & Research Centre, Bhopal, India...
March 2017: Germs
https://www.readbyqxmd.com/read/28330892/in-vitro-susceptibility-testing-of-tedizolid-against-nontuberculous-mycobacteria
#4
Barbara A Brown-Elliott, Richard J Wallace
Tedizolid is a new oxazolidinone with improved in vitro and intracellular potency against Mycobacterium tuberculosis, including multidrug resistant strains, and some species of nontuberculous mycobacteria (NTM) compared with linezolid.Using the current Clinical and Laboratory Standards Institute (CLSI) recommended method of broth microdilution, susceptibility testing of 170 isolates of rapidly growing mycobacteria showed equivalent or lower (1- to 8-fold MIC50 and/or MIC90 values) for tedizolid compared to linezolid...
March 22, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28326308/infection-sources-of-a-common-non-tuberculous-mycobacterial-pathogen-mycobacterium-avium-complex
#5
REVIEW
Yukiko Nishiuchi, Tomotada Iwamoto, Fumito Maruyama
Numerous studies have revealed a continuous increase in the worldwide incidence and prevalence of non-tuberculous mycobacteria (NTM) diseases, especially pulmonary Mycobacterium avium complex (MAC) diseases. Although it is not clear why NTM diseases have been increasing, one possibility is an increase of mycobacterial infection sources in the environment. Thus, in this review, we focused on the infection sources of pathogenic NTM, especially MAC. The environmental niches for MAC include water, soil, and dust...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28317809/treatment-outcome-in-children-with-nontuberculous-mycobacterial-lymphadenitis-a-retrospective-follow-up-study
#6
Annicka Reuss, Sarah Drzymala, Barbara Hauer, Rüdiger von Kries, Walter Haas
INTRODUCTION: Information on the long-term treatment outcome following nontuberculous mycobacterial (NTM) lymphadenitis is very limited. We performed a study to (a) compare cure rates following different initial treatment courses, (b) describe subsequent treatment courses and their outcomes, and (c) determine the occurrence of late sequelae in immunocompetent children with NTM lymphadenitis. MATERIALS AND METHODS: In 2011, we conducted a retrospective follow-up study in 71 parents whose children had been hospitalized with NTM disease 2002-2005...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28317808/isolation-and-characterization-of-nontuberculous-mycobacteria-from-patients-with-pulmonary-tuberculosis-in-ghana
#7
Isaac Darko Otchere, Adwoa Asante-Poku, Stephen Osei-Wusu, Samuel Yaw Aboagye, Dorothy Yeboah-Manu
OBJECTIVE/BACKGROUND: Nontuberculous mycobacterial (NTM) species are assuming public health importance in pulmonary diseases; they are increasingly being isolated, and importantly, most NTMs do not respond to routine tuberculosis (TB) drugs. This study aimed to identify NTMs isolated from pulmonary TB cases and also determine their susceptibility to streptomycin (STR), isoniazid (INH), and rifampicin (RIF). METHODS: A total of 1755 mycobacterial isolates, obtained between August 2012 and July 2014, from 2036 smear-positive pulmonary cases were identified using polymerase chain reaction amplification of IS6110, and hsp65 gene sequencing analysis...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28317802/port-site-infections-by-nontuberculous-mycobacterium-a-retrospective-clinico-microbiological-study
#8
Roumi Ghosh, Soumen Das, Asmita De, Harish Kela, Makhan Lal Saha, Prasanta Kumar Maiti
BACKGROUND: Port-site infection (PSI) is a prevailing, chronic, nagging, treatment refractory complication of laparoscopic surgery (LS). It neutralizes the advantages of minimally invasive surgery and increases morbidity, treatment cost of patient, leading to loss of confidence on operating surgeon. PSIs are preventable with appropriate preoperative, intraoperative, and postoperative measures. Atypical mycobacterium is most commonly associated with nonhealing postlaparoscopic wound infections, causing outbreaks or sporadic cases worldwide...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28317798/nontuberculous-mycobacterial-species-and-mycobacterium-tuberculosis-complex-coinfection-in-patients-with-pulmonary-tuberculosis-in-dr-soetomo-hospital-surabaya-indonesia
#9
Ni Made Mertaniasih, Deby Kusumaningrum, Eko Budi Koendhori, Tutik Kusmiati, Desak Nyoman Surya Suameitria Dewi
OBJECTIVE/BACKGROUND: The aim of this study was to analyze the detection of nontuberculous mycobacterial (NTM) species derived from sputum specimens of pulmonary tuberculosis (TB) suspects. Increasing prevalence and incidence of pulmonary infection by NTM species have widely been reported in several countries with geographical variation. MATERIALS AND METHODS: Between January 2014 and September 2015, sputum specimens from chronic pulmonary TB suspect patients were analyzed...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28297817/-distribution-and-drug-resistance-of-nontuberculous-mycobacteria-in-beijing
#10
J Zhang, J R Su, B C Ding, J W Liu, J L Yi, X Y Yang, N H Wang, S M Wang
Objective: To analyze the distribution and drug resistance of nontuberculous mycobacteria(NTM) in Beijing. Methods: Using PCR-fluorescence probe method we identified 1 552 mycobacterial isolates in 2009 and 1 553 mycobacterial isolates in 2013, which were stored by Beijing Research Institute for Tuberculosis Control.All identified NTM strains were confirmed by 16S rRNA gene sequencing, and drug sensitivity testing was performed by using 1% ratio method.SPSS 13.0 was used for statistical analysis. Results: The isolation rate for NTM in 2009 and 2013 was 3...
March 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28280641/prosthetic-joint-infection-due-to-mycobacterium-avium-intracellulare-in-a-patient-with-rheumatoid-arthritis-a-case-report-and-review-of-the-literature
#11
Nicholas E Ingraham, Brenton Schneider, Jonathan D Alpern
Nontuberculous mycobacteria (NTM) are a rare cause of prosthetic joint infections (PJI). However, the prevalence of NTM infections may be increasing with the rise of newer immunosuppressive medications such as biologics. In this case report, we describe a rare complication of immunosuppressive therapies and highlight the complexity of diagnosing and treating PJI due to NTM. The patient is a 79-year-old Caucasian male with a history of severe destructive rheumatoid arthritis on several immunosuppressive agents and right hip osteoarthritis s/p total hip arthroplasty 15 years previously with several complex revisions, presenting with several weeks of worsening right hip and abdominal pain...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28271647/mycobacterium-kansasii-pneumonia-with-mediastinal-lymphadenitis-in-a-patient-with-acute-myeloid-leukemia-successful-treatment-to-stem-cell-transplantation
#12
Yeon Geun Choi, Sung Yeon Cho, Dong Gun Lee, Eunjung Yim, Hyonsoo Joo, Seongyul Ryu, Jae Ki Choi, Hee Je Kim
Non-tuberculous mycobacterial (NTM) disease is a relatively rare cause of neutropenic fever in patients with hematologic malignancies. During the neutropenic period, performing invasive procedures for microbiological or pathological confirmation is difficult. In addition, the optimal treatment duration for NTM disease in patients with leukemia, especially prior to stem cell transplantation (SCT), has not been documented. Therefore, we report a case of pneumonia with necrotizing lymphadenitis caused by Mycobacterium kansasii diagnosed during chemotherapy being performed for acute myeloid leukemia...
January 19, 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28265761/risk-factors-of-non-tuberculous-mycobacterial-lymphadenitis-in-children-a-case-control-study
#13
Patricia W Garcia-Marcos, Mercedes Plaza-Fornieles, Ana Menasalvas-Ruiz, Ramon Ruiz-Pruneda, Pedro Paredes-Reyes, Santiago Alfayate Miguelez
The aim of the present study is to clarify the association between environmental exposures and non-tuberculous mycobacterial (NTM) lymphadenitis, during the last decade, in a population of children. In children up to 14 years of age in a pediatric tertiary hospital, all cases of NTM lymphadenopathy with a specific microbiological diagnosis, from January 2004 to January 2015, were reviewed. This is a case-control study (1:5 proportion), in which the prevalence of environmental factors between cases and controls was compared by means of a multivariate logistic regression analysis...
March 6, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28255087/cough-physiology-in-elderly-women-with-nontuberculous-mycobacterial-ntm-lung-infections
#14
Hsiu-Wen Tsai, Kevin Fennelly, Karen Wheeler Hegland, Sherry Adams, Jillian A Condrey, Jennifer L Hosford, Paul W Davenport
Elderly white, thin, nonsmoking women appear to be more susceptible to lung infections with Mycobacterium avium complex and other nontuberculous mycobacteria (NTM). It has been postulated that such disease in women is related to the suppression of their cough. We hypothesized that subjects with pulmonary NTM (pNTM) infections may have altered cough physiology compared to unaffected control subjects. We used capsaicin induced cough to assess their cough reflex. Eight white elderly women with stable chronic pNTM lung infections and six unaffected age matched control subjects were recruited...
March 2, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28252353/investigation-of-mycobacterium-avium-complex-mac-in-australian-commercial-milk-using-qpcr
#15
Shraddha Adhikari, Tanya Caro Tohme, Harriet Whiley
This technical research communication describes the first study to use quantitative polymerase chain reaction (qPCR) to investigate the presence of Mycobacterium avium complex (MAC) in Australian pasteurised milk. MAC is the most common NTM responsible for human illnesses and includes M. avium subspecies paratuberculosis (MAP). MAC is a causative agent of lymphadenitis in children, with contaminated food and water considered as a likely source. As such the presence of MAC in milk would have public health significance...
February 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/28248677/variable-number-tandem-repeat-markers-for-mycobacterium-intracellulare-genotyping-comparison-to-the-16s-rrna-gene-sequencing
#16
COMPARATIVE STUDY
Kaisen Chen, Yangyi Zhang, Yiping Peng
INTRODUCTION: Characterizing Mycobacterium intracellulare responsible for nontuberculous mycobacterial (NTM) infections may aid in controlling outbreaks. This study aimed to compare 16S ribosomal ribonucleic acid (rRNA) sequencing and variable-number tandem repeat (VNTR) genotyping of M. intracellulare strains isolated from clinical samples, and to characterize VNTR clusters associated with NTM infections or cavity formation. METHODOLOGY: Sputum samples were obtained from 77 HIV-negative patients with pulmonary disease between 2009 and 2013...
February 28, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28242674/in-vitro-activity-of-bedaquiline-against-nontuberculous-mycobacteria-in-china
#17
Yu Pang, Huiwen Zheng, Yaoju Tan, Yuanyuan Song, Yanlin Zhao
The main goal of our study was to evaluate in vitro drug susceptibility of bedaquiline against six prevalent pathogenic nontuberculous mycobacteria (NTM) diseases in China. In addition, we investigated the potential molecular mechanism contributing to the bedaquiline resistance in these different NTM species. For slowly growing mycobacteria (SGM), bedaquiline exhibited the highest activity against Mycobacterium avium, the MIC50 and MIC90 were 0.03 and 16 mg/L, respectively. Of rapidly growing mycobacteria (RGM), Mycobacterium abscessus subsp...
February 27, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28241317/tgf%C3%AE-2-induces-the-formation-of-cross-linked-actin-networks-clans-in-human-trabecular-meshwork-cells-through-the-smad-and-non-smad-dependent-pathways
#18
Michela Montecchi-Palmer, Jaclyn Y Bermudez, Hannah C Webber, Gaurang C Patel, Abbot F Clark, Weiming Mao
Purpose: Increased intraocular pressure results from increased aqueous humor (AH) outflow resistance at the trabecular meshwork (TM) due to pathologic changes including the formation of cross-linked actin networks (CLANs). Transforming growth factor β2 (TGFβ2) is elevated in the AH and TM of primary open angle glaucoma (POAG) patients and induces POAG-associated TM changes, including CLANs. We determined the role of individual TGFβ2 signaling pathways in CLAN formation. Methods: Cultured nonglaucomatous human TM (NTM) cells were treated with control or TGFβ2, with or without the inhibitors of TGFβ receptor, Smad3, c-Jun N-terminal kinases (JNK), extracellular signal regulated kinase (ERK), P38, or Rho-associated protein kinase (ROCK)...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28241021/extracellular-vesicles-mediate-signaling-between-the-aqueous-humor-producing-and-draining-cells-in-the-ocular-system
#19
Natalie Lerner, Sofia Avissar, Elie Beit-Yannai
PURPOSE: Canonical Wnt signaling is associated with glaucoma pathogenesis and intraocular pressure (IOP) regulation. Our goal was to gain insight into the influence of non-pigmented ciliary epithelium (NPCE)-derived exosomes on Wnt signaling by trabecular meshwork (TM) cells. The potential impact of exosomes on Wnt signaling in the ocular drainage system remains poorly understood. METHODS: Exosomes isolated from media collected from cultured NPCE cells by differential ultracentrifugation were characterized by dynamic light scattering (DLS), tunable resistive pulse sensing (TRPS), and nanoparticle tracking analysis (NTA), sucrose density gradient migration and transmission electron microscopy (TEM)...
2017: PloS One
https://www.readbyqxmd.com/read/28230286/identification-of-nontuberculous-mycobacteria-using-multilocous-sequence-analysis-of-16s-rrna-hsp65-and-rpob
#20
Si Hyun Kim, Jeong Hwan Shin
BACKGROUND: The isolation of nontuberculous mycobacteria (NTM) from clinical specimens has increased, and they now are considered significant opportunistic pathogens. The aims of this study were to develop a database and interpretive criteria for identifying individual species. In addition, using clinical isolates, we evaluated the clinical usefulness of 16S rRNA, hsp65, and rpoB as target genes for this method. METHODS: The sequences of NTM for 16S rRNA, hsp65, and rpoB were collected from GenBank and checked by manual inspection...
February 23, 2017: Journal of Clinical Laboratory Analysis
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