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https://www.readbyqxmd.com/read/29773296/nontuberculous-mycobacterial-and-aspergillus-infections-among-cadaveric-lung-transplant-recipients-in-japan
#1
Kazunobu Tachibana, Yoshinori Okada, Yasushi Matsuda, Kentaroh Miyoshi, Takahiro Oto, Toyofumi F Chen-Yoshikawa, Hiroshi Date, Masato Minami, Meinoshin Okumura, Akinori Iwasaki, Takeshi Shiraishi, Sumiko Maeda, Yuji Matsumura, Takahiro Nakajima, Ichiro Yoshino, Seiji Hayashi
BACKGROUND: Lung transplantation is an effective treatment modality for respiratory failure. Chronic lung infections, including infections caused by nontuberculous mycobacteria (NTM) and Aspergillus, are difficult to control, and uncontrolled infections are relative contraindications for lung transplantation. However, few reports have documented the incidence and outcome of these infections in lung transplant recipients. METHODS: To quantify the incidence and outcomes of colonization and disease caused by NTM and aspergillosis in recipients before and after lung transplantation, we reviewed the medical records and microbiology data from 240 consecutive cadaveric lung transplant recipients between 2000 and 2014...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29773279/-non-tuberculous-mycobacterial-cervical-adenitis-in-children-2-cases
#2
N Sigg, S Bailleul, J-M Turmel, G Legrand, S Kettani, L Martin
BACKGROUND: Cervical lymphadenitis is the most common manifestation of infection with nontuberculous mycobacteria (NTM) in immunocompetent children. Nevertheless, it is poorly known by dermatologists. Its incidence, which is currently increasing since the cessation of BCG vaccination in 2007, raises several issues regarding its pathophysiology, diagnosis and management. PATIENTS AND METHODS: We report two cases of NTM adenitis: one in a 2-year-old girl vaccinated with BCG and one in an unvaccinated 22-month-old boy, in whom a misleading presentation led to delayed diagnosis...
May 14, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29773092/preliminary-study-on-drug-susceptibility-profile-and-resistance-mechanisms-to-macrolides-of-clinical-isolates-of-non-tuberculous-mycobacteria-from-china
#3
Fu Li, Gui Lian Li, Hui Pang, Hai Can Liu, Tong Yang Xiao, Shuang Jun Li, Qiao Luo, Yi Jiang, Rui Bai Wang, Kang Lin Wan
OBJECTIVE: Macrolide susceptibility and drug resistance mechanisms of clinical non-tuberculous mycobacteria (NTM) isolates were preliminarily investigated for more accurate diagnosis and treatment of the infection in China. METHODS: Four macrolides, including clarithromycin (CLAR), azithromycin (AZM), roxithromycin (ROX), and erythromycin (ERY), were used to test the drug susceptibility of 310 clinical NTM isolates from six provinces of China with the broth microdilution method...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29772918/cutaneous-nontuberculous-mycobacterial-infections-in-alberta-canada-an-epidemiologic-study-and-review
#4
Megan A Sander, Judith L Isaac-Renton, Gregory J Tyrrell
BACKGROUND: Cutaneous infections caused by nontuberculous mycobacteria (NTM) occur infrequently. Nonetheless, the incidence of NTM infections is reported to be increasing. In Canada, cutaneous NTM infections have not been well described. OBJECTIVES: A database review from 2006 to 2016 was done to assess species frequency, incidence, and trends of the most common cutaneous NTMs in the province of Alberta, Canada. We also reviewed major diagnostic and epidemiologic aspects of NTM cutaneous infections with a focus on Mycobacterium marinum...
May 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29764749/prognosis-of-chronic-pulmonary-aspergillosis-in-patients-with-pulmonary-non-tuberculous-mycobacterial-disease
#5
Maiko Naito, Yu Kurahara, Shiomi Yoshida, Naoya Ikegami, Takehiko Kobayashi, Shojiro Minomo, Kazunobu Tachibana, Kazunari Tsuyuguchi, Seiji Hayashi, Katsuhiro Suzuki
BACKGROUND: Pulmonary non-tuberculous mycobacterial disease (PNTM) is a known risk factor for chronic pulmonary aspergillosis (CPA). However, few studies have focused on the prognosis of PNTM-associated CPA. In the present investigation, we aimed to elucidate the clinical course and prognostic factors of CPA in patients with PNTM. METHODS: We retrospectively investigated the medical records of 62 patients with CPA and a history of PNTM who were admitted to Kinki-chuo Chest Medical Center between 2010 and 2015...
May 11, 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29764381/isolation-of-mycobacterium-arupense-from-pleural-effusion-culprit-or-not
#6
Xian Zhou, Qiaoling Ruan, Weimin Jiang, Xinyu Wang, Yuan Jiang, Shenglei Yu, Yu Xu, Jing Li, Yangyi Zhang, Wenhong Zhang, Yuekai Hu
BACKGROUND: Mycobacterium arupense, first identified in 2006, is a slow-growing nontuberculous mycobacterium (NTM) and an emerging cause of tenosynovitis, potentially associated with immunosuppression. However, unlike the diagnostic value of its isolation from osteoarticular specimens, the significance of detecting M. arupense in respiratory specimens is not yet clear. CASE PRESENTATION: To our knowledge, we, for the first time, described the identification of M...
May 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29760130/-mycobacterium-simiae-clinical-radiological-and-microbiological-characteristics-in-97-patients
#7
Nathalie Coolen-Allou, Thomas Touron, Olivier Belmonte, Virgile Gazaille, Michel Andre, Jérôme Allyn, Sandrine Picot, Annabelle Payet, Nicolas Veziris
Mycobacterium simiae is a rare species of slow-growing nontuberculous mycobacteria (NTM).From 2002 to 2017, we conducted a retrospective study that included all patients with NTM-positive respiratory samples detected in two university hospitals of the French overseas department of Reunion Island. We recorded the prevalence of M. simiae in this cohort, as well as the clinical, radiological, and microbiological features of patients with at least one sample positive for M. simiae In our cohort, 97 patients (15...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29760127/-in-vitro-activity-of-clofazimine-against-non-tuberculous-mycobacteriaisolated-in-beijing-china
#8
Jingjing Luo, Xia Yu, Guanglu Jiang, Yuhong Fu, Fengmin Huo, Yifeng Ma, Fen Wang, Yuanyuan Shang, Qian Liang, Yi Xue, Hairong Huang
Due to the natural resistance of non-tuberculous mycobacteria(NTM) to lots of antibiotics,treatment of diseases caused by NTM is often long-termed but less successful.The main goal of this study was to evaluate the in vitro susceptibility to clofazimine of 209 isolates consisting of different NTM species isolated in Beijing,China. Furthermore,47 reference strains were also tested, including 30 rapidly growing mycobacterium (RGM) species and 17 slowly growing mycobacterium(SGM) species.The potential molecular mechanism contributing to clofazimine resistance of NTM was investigated as well...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29757583/what-immunological-defects-predispose-to-non-tuberculosis-mycobacterial-infections
#9
Esmaeil Mortaz, Milad Moloudizargari, Mohammad Varahram, Mehrnaz Movassaghi, Johan Garssen, Mehdi Kazempour Dizagie, Mehdi Mirsaeidi, Ian M Adcock
Nontuberculous mycobacteria (NTM) are categorized as one of the large and diverse groups of environmental organisms which are abundant in water and soil.  NTM cause a variety of diseases in humans that mainly affect the lung. A predisposition to pulmonary NTM is evident in patients with parenchymal structural diseases including bronchiectasis, emphysema, tuberculosis (TB), cystic fibrosis (CF), rheumatologic lung diseases and other chronic diseases with pulmonary manifestations. Lung infections are not the only consequences of being infected by NTM as they can also infect skin and soft tissue and may also cause lymphadenitis (predominantly in young children) and disseminated disease in human immunodeficiency virus (HIV)-infected patients or those with severely compromised immune system...
April 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29754381/non-tuberculous-mycobacterial-infections-in-thoracic-transplant-candidates-and-recipients
#10
REVIEW
Mana Rao, Fernanda P Silveira
PURPOSE OF REVIEW: To review and discuss the epidemiology, risk factors, clinical presentation, diagnosis, and treatment of non-tuberculous mycobacteria (NTM) in thoracic transplantation. RECENT FINDINGS: Non-tuberculous mycobacteria are ubiquitous but are an uncommon cause of disease after solid organ transplantation. The incidence of infection is higher in thoracic transplant recipients than in abdominal transplant recipients, with most cases seen after lung transplantation...
May 12, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29740544/establishment-of-a-host-to-host-transmission-model-for-mycobacterium-avium-subsp-hominissuis-using-caenorhabditis-elegans-and-identification-of-colonization-associated-genes
#11
Luiz E Bermudez, Sasha J Rose, Jamie L Everman, Navid R Ziaie
Mycobacterium avium subsp. hominissuis ( M. avium ) is a member of the non-tuberculous mycobacteria (NTM), and is a common cause of lung infection in patients with chronic NTM lung conditions. M. avium is an environmental bacterium believed to be transmitted from environmental sources. In this work we used a recently developed model in Caenorhabditis elegans to ask whether M. avium can be transmitted from host-to-host, and the bacterial genes associated with host colonization. Infection of C. elegans was carried out by placing the nematode in cultured with M...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29729715/non-tuberculous-mycobacteria-can-cause-disseminated-mycobacteriosis-in-cats
#12
H Pekkarinen, N Airas, L E Savolainen, M Rantala, S Kilpinen, O Miuku, M Speeti, V Karkamo, S Malkamäki, M Vaara, A Sukura, P Syrjä
Mycobacteriosis caused by non-tuberculous mycobacteria (NTM) is a rising concern in human medicine both in immunocompromised and immunocompetent patients. In cats, mycobacteriosis caused by NTM is considered mostly to be a focal or dermal infection, with disseminated disease mostly caused by Mycobacterium avium. We describe three cases of disseminated mycobacteriosis in cats, caused by Mycobacterium malmoense, Mycobacterium branderi/shimoidei and M. avium, with no identified underlying immunosuppression. In all cases, extracellular mycobacteria were seen in the pulmonary epithelium, intestinal lumen and glomerular tufts, which could affect the shedding of the organism...
April 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29724184/high-mortality-in-patients-with-mycobacterium-avium-complex-lung-disease-a-systematic-review
#13
Roland Diel, Marc Lipman, Wouter Hoefsloot
BACKGROUND: The incidence of nontuberculous mycobacterial (NTM) pulmonary disease caused by Mycobacterium avium complex (MAC) in apparently immune-competent people is increasing worldwide. We performed a systematic review of the published literature on five-year all-cause mortality in patients with MAC lung disease, and pooled the mortality rates to give an overall estimate of five-year mortality from these studies. METHODS: We systematically reviewed the literature up to 1st August 2017 using PubMed® and ProQuest Dialog™ to search Medline® and Embase® databases, respectively...
May 3, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29712660/novel-mutations-associated-with-clofazimine-resistance-in-mycobacterium-abscessus
#14
Yuanyuan Chen, Jiazhen Chen, Shuo Zhang, Wanliang Shi, Wenhong Zhang, Min Zhu, Ying Zhang
Mycobacterium abscessus ( Mab ) is a major non-tuberculous mycobacterial (NTM) pathogen responsible for about 80% of all pulmonary infections caused by rapidly growing mycobacteria. Clofazimine is an effective drug active against Mab , but the mechanism of resistance to clofazimine in Mab is unknown. To investigate the molecular basis of clofazimine resistance in Mab. We isolated 29 Mab mutants resistant to clofazimine, and subjected them to whole genome sequencing to identify possible mutations associated with clofazimine resistance...
April 30, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29707345/hiv-negative-pulmonary-disease-caused-by-nontuberculous-mycobacteria-in-southern-brazil-clinical-and-microbiological-characterization
#15
Fernanda Guioti Puga, Renata Helena Candido Pocente, Erica Chimara, Valdes Roberto Bollela
Background: Nontuberculous mycobacteria (NTM) have been identified with increasing frequency in the clinical practice. The aim of this study was to characterize NTM isolates in respiratory specimens from patients with pulmonary disease and to correlate this with clinical/radiological findings, decision to start treatment and outcomes. Methods: A cross-sectional descriptive study was performed and included all patients who had at least one NTM isolated in respiratory specimens between 2011 and 2014...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29679902/new-lipophilic-isoniazid-derivatives-and-their-1-3-4-oxadiazole-analogues-synthesis-antimycobacterial-activity-and-investigation-of-their-mechanism-of-action
#16
Rudolf Vosátka, Martin Krátký, Markéta Švarcová, Jiří Janoušek, Jiřina Stolaříková, Jan Madacki, Stanislav Huszár, Katarína Mikušová, Jana Korduláková, František Trejtnar, Jarmila Vinšová
The development of novel drugs is essential for the treatment of tuberculosis and other mycobacterial infections in future. A series of N-alkyl-2-isonicotinoylhydrazine-1-carboxamides was synthesized from isoniazid (INH) and then cyclized to N-alkyl-5-(pyridin-4-yl)-1,3,4-oxadiazole-2-amines. All derivatives were characterised spectroscopically. The compounds were screened for their in vitro antimycobacterial activity against susceptible and multidrug-resistant Mycobacterium tuberculosis (Mtb.) and nontuberculous mycobacteria (NTM; M...
April 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29675789/experimental-platform-utilising-melting-curve-technology-for-detection-of-mutations-in-mycobacterium-tuberculosis-isolates
#17
Agnieszka Broda, Vlad Nikolayevskyy, Nicki Casali, Huma Khan, Richard Bowker, Gemma Blackwell, Bhakti Patel, James Hume, Waqar Hussain, Francis Drobniewski
Tuberculosis (TB) remains one of the most deadly infections with approximately a quarter of cases not being identified and/or treated mainly due to a lack of resources. Rapid detection of TB or drug-resistant TB enables timely adequate treatment and is a cornerstone of effective TB management. We evaluated the analytical performance of a single-tube assay for multidrug-resistant TB (MDR-TB) on an experimental platform utilising RT-PCR and melting curve analysis that could potentially be operated as a point-of-care (PoC) test in resource-constrained settings with a high burden of TB...
April 20, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29670585/maldi-spectra-database-for-rapid-discrimination-and-subtyping-of-mycobacterium-kansasii
#18
Jayaseelan Murugaiyan, Astrid Lewin, Elisabeth Kamal, Zofia Bakuła, Jakko van Ingen, Vit Ulmann, Miren J Unzaga Barañano, Joanna Humięcka, Aleksandra Safianowska, Uwe H Roesler, Tomasz Jagielski
Mycobacterium kansasii is an emerging non-tuberculous mycobacterial (NTM) pathogen capable of causing severe lung disease. Of the seven currently recognized M. kansasii genotypes (I-VII), genotypes I and II are most prevalent and have been associated with human disease, whereas the other five (III-VII) genotypes are predominantly of environmental origin and are believed to be non-pathogenic. Subtyping of M. kansasii serves as a valuable tool to guide clinicians in pursuing diagnosis and to initiate the proper timely treatment...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29661870/amikacin-inhalation-as-salvage-therapy-for-refractory-nontuberculous-mycobacterial-lung-disease
#19
Byung Woo Jhun, Bumhee Yang, Seong Mi Moon, Hyun Lee, Hye Yun Park, Kyeongman Jeon, O Jung Kwon, Jungmin Ahn, Il Joon Moon, Sung Jae Shin, Charles L Daley, Won-Jung Koh
Although guidelines recommend amikacin (AMK) inhalation therapy for difficult-to-treat nontuberculous mycobacterial lung disease (NTM-LD), data are limited regarding the safety and clinical efficacy of this salvage therapy. We retrospectively evaluated treatment outcomes of 77 patients with refractory NTM-LD caused by Mycobacterium abscessus complex (MABC) or M. avium complex (MAC) who initiated AMK inhalation therapy between February 2015 and June 2016. MABC was the most common etiology (n = 48, 62%), followed by MAC (n = 20, 26%) and mixed infections (n = 9, 12%)...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29649431/diagnosis-and-management-of-children-with-mycobacterium-abscessus-infections-in-the-head-and-neck
#20
Justine Moe, Roy Rajan, Shelley Caltharp, Shelly Abramowicz
PURPOSE: Controversy exists regarding the most appropriate treatment strategy for children with nontuberculous mycobacterial (NTM) cervical lymphadenitis. Mycobacterium abscessus (MAB) is an uncommon cause of NTM cervical lymphadenitis. The purpose of the present study was to evaluate diagnosis, management, and treatment outcomes in children with MAB-associated cervical lymphadenitis resulting from a pulpotomy. MATERIALS AND METHODS: This was a retrospective chart review of children with NTM lymphadenitis of the head and neck caused by MAB treated at Children's Healthcare of Atlanta hospitals (Atlanta, GA)...
March 22, 2018: Journal of Oral and Maxillofacial Surgery
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