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https://www.readbyqxmd.com/read/28448082/effects-of-gender-and-age-on-immune-responses-of-human-peripheral-blood-mononuclear-cells-to-probiotics-a-large-scale-pilot-study
#1
Y-H Ho, Y-T Huang, Y-C Lu, S-Y Lee, M-F Tsai, S-P Hung, T-Y Hsu
BACKGROUND: Despite the widely accepted concept that probiotics confer miscellaneous benefits to hosts, the controversies surrounding these health-promoting claims cannot be ignored. These controversies hinder development and innovation in this field. RESULTS: To clarify the effects of age and gender on probiotic-induced immune responses, we recruited 1613 Taiwanese individuals and calculated the ratio of IFN-γ to IL-10 production after each individual's PBMCs were stimulated by six probiotic strains (L...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28437455/effect-of-a-probiotic-beverage-consumption-enterococcus-faecium-crl-183-and-bifidobacterium-longum-atcc-15707-in-rats-with-chemically-induced-colitis
#2
Larissa Sbaglia Celiberto, Raquel Bedani, Naiara Naiana Dejani, Alexandra Ivo de Medeiros, José Antonio Sampaio Zuanon, Luis Carlos Spolidorio, Maria Angela Tallarico Adorno, Maria Bernadete Amâncio Varesche, Fábio Carrilho Galvão, Sandro Roberto Valentini, Graciela Font de Valdez, Elizeu Antonio Rossi, Daniela Cardoso Umbelino Cavallini
BACKGROUND: Some probiotic strains have the potential to assist in relieving the symptoms of inflammatory bowel disease. The impact of daily ingestion of a soy-based product fermented by Enterococcus faecium CRL 183 and Lactobacillus helveticus 416 with the addition of Bifidobacterium longum ATCC 15707 on chemically induced colitis has been investigated thereof within a period of 30 days. METHODS: Colitis was induced by dextran sulfate sodium. The animals were randomly assigned into five groups: Group C: negative control; Group CL: positive control; Group CLF: DSS with the fermented product; Group CLP: DSS with the non-fermented product (placebo); Group CLS: DSS with sulfasalazine...
2017: PloS One
https://www.readbyqxmd.com/read/28434154/protective-effects-of-cell-free-supernatant-and-live-lactic-acid-bacteria-isolated-from-thai-pigs-against-a-pandemic-strain-of-porcine-epidemic-diarrhea-virus
#3
Wandee Sirichokchatchawan, Gun Temeeyasen, Dachrit Nilubol, Nuvee Prapasarakul
Porcine epidemic diarrhea virus (PEDV) is a coronavirus which causes severe diarrhea and fatal dehydration in piglets. In general, probiotic supplements could enhance recovery and protect piglets against enteric pathogens. Seven local lactic acid bacteria (LAB), (Ent. faecium 79N and 40N, Lact. plantarum 22F, 25F and 31F, Ped. acidilactici 72N and Ped. pentosaceus 77F) from pig feces were well-characterized as high potential probiotics. Cell-free supernatants (CFS) and live LAB were evaluated for antiviral activities by co-incubation on Vero cells and challenged with a pandemic strain of PEDV isolated from pigs in Thailand...
April 22, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28431095/avi-lution%C3%A2-supplemented-at-1-0-or-2-0%C3%A2-g-kg-in-feed-improves-the-growth-performance-of-broiler-chickens-during-challenge-with-bacitracin-resistant-clostridium-perfringens
#4
L A Krueger, D A Spangler, D R Vandermyde, M D Sims, G A Ayangbile
Avi-Lution® is a defined, patented, synbiotic product containing Saccharomyces cerevisiae, Enterococcus faecium, and Bacillus spp. Broiler chickens (n = 1,250) were experimentally treated as uninoculated controls (uCon), inoculated controls (iCon) with Clostridium perfringens, or inoculated and treated with bacitracin methylene disalicylate (BMD) at 55 mg/kg as an infected/treated control or Avi-Lution® at 1.0 (AvL1) or 2.0 (AvL2) g/kg in feed for 42 d. Each treatment was applied to 10 replicate pens of 25 straight-run, newly hatched chicks...
April 18, 2017: Poultry Science
https://www.readbyqxmd.com/read/28427133/-effects-of-application-of-vancomycin-in-the-early-stage-of-patients-with-extremely-severe-burn
#5
Z Zhu, G W Cao, J J Bao, Z H Hu, Z Shen, H Tao, B Cao, F Xu
Objective: To evaluate the effects of application of vancomycin in the early stage of patients with extremely severe burn, in order to provide reference to drug for anti-infection treatment in the early stage of patients with extremely severe burn. Methods: Data of 15 patients of Kunshan explosion on August 2nd, 2014, admitted to the Department of Intensive Care in our hospital were retrospectively analyzed. The clinical efficacy of continuously intravenous dripping of vancomycin (combined with imipenem) in the early stage of burns (before and on post burn day 14) was analyzed...
April 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28426995/antibacterial-activity-of-n-methylbenzofuro-3-2-b-quinoline-and-n-methylbenzoindolo-3-2-b-quinoline-derivatives-and-study-of-their-mode-of-action
#6
Ning Sun, Ruo-Lan Du, Yuan-Yuan Zheng, Bao-Hua Huang, Qi Guo, Rui-Fang Zhang, Kwok-Yin Wong, Yu-Jing Lu
The emergence of multidrug-resistant bacteria causes an urgent need for new generation of antibiotics, which may have a different mechanism of inhibition or killing action from the existing. Targeting at the inhibition of bacterial cell division via the control of FtsZ function is one of the effective and promising approaches. Some natural extracts from plants such as sanguinarine and berberine (analogs of pyridinium compounds) are known to alter FtsZ function. In this study, a series of novel quaternary pyridinium compounds was constructed based on the N-methylbenzofuro[3,2-b]quinoline and N-methylbenzoindolo[3,2-b]-quinoline derivatives and their antibacterial activity against nine significant pathogens was investigated using broth microdilution method...
April 15, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28423435/-pathogen-spectrum-of-complex-wounds-in-germany-from-war-zones
#7
Hans Joachim Riesner, Benedikt Friemert, Patricia Lang, Hans Georg Palm, Arnold J Suda
Background Treatment of the injured from war zones with wounds with multi-resistant pathogens is becoming more common in Germany, especially in German Armed Forces Hospitals. In most cases, the pre-treatment of these patients has been inadequate and they have a high load of rare pathogens. In Germany, hospitals have to evaluate these pathogens by law. The aim of this study was to review current German guidelines and data on the array of pathogens of complex trauma wounds in Germany and to compare patients with wounds and multi-resistant pathogens from war zones treated in Germany...
April 19, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28422890/an-unusual-location-of-gouty-panniculitis-a-case-report
#8
David Martin, Gaëtan-Romain Joliat, Pierre Fournier, Christophe Brunel, Nicolas Demartines, Olivier Gié
RATIONALE: Gouty panniculitis, characterised by the deposition of monosodium urate crystals in subcutaneous tissue, is a rare clinical manifestation of gout. PATIENT CONCERNS: The case of a 67-year-old man is reported, who presented an erythematous nodule on the upper part of the right buttock suspicious for an abscess. This was in the context of chemotherapy for non-Hodgkin's lymphoma. DIAGNOSES: Histopathologic examination demonstrated gouty panniculitis...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28414918/frogs-host-faecal-bacteria-typically-associated-with-humans
#9
Karen Gibb, Xavier Schobben, Keith Christian
Tree frogs commonly access drinking water tanks, which may have human health implications. Although amphibians might not be expected to host mammalian faecal indicator bacteria (FIB), it is possible that they may have human FIB on their skin after exposure to human waste. We collected faeces and skin wash from green tree frogs (Litoria caerulea) from a natural environment, a suburban site, and a suburban site near a creek occasionally contaminated with sewage effluent. We used molecular techniques to test for FIB that are routinely used to indicate human faecal contamination...
April 17, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28414678/what-the-eyes-don-t-see-the-heart-does-grieve-over
#10
M Sciaudone, M Dery
INTRODUCTION: A 71 year old Peruvian woman presented with blurry vision and bilateral eye pain and had evidence of bilateral endophthalmitis on eye examination. Her past medical history was notable for multiple abdominal surgeries within the preceding months, including an incarcerated inguinal hernia repair which required an ileostomy placement, and cholecystitis requiring cholecystostomy tube placement. Over her multiple long hospitalizations, she developed bacteremia and fungemia on several occasions, with organisms including Enterobacter cloacae, Klebsiella pneumoniae, Bacteroides fragilis, Pseudomonas aeruginosa, Enterococcus faecium, and Candida albicans...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28403894/antibiotic-resistant-airborne-bacteria-and-their-multidrug-resistance-pattern-at-university-teaching-referral-hospital-in-south-ethiopia
#11
Fithamlak Bisetegen Solomon, Fiseha Wada Wadilo, Amsalu Amache Arota, Yishak Leka Abraham
BACKGROUND: Hospitals provide a reservoir of microorganisms, many of which are multi-resistant to antibiotics. Emergence of multi-drug resistant strains in a hospital environment, particularly in developing countries is an increasing problem to infection treatment. This study aims at assessing antibiotic resistant airborne bacterial isolates. METHODS: A cross-sectional study was conducted at Wolaita Sodo university teaching and referral Hospital. Indoor air samples were collected by using passive air sampling method...
April 12, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28403547/effects-of-dietary-supplementation-with-a-probiotic-enterococcus-faecium-dsm-7134-on-growth-performance-nutrient-digestibility-and-gut-health-status-in-weaning-pigs
#12
R X Lan, I H Kim
BACKGROUND: Probiotics have been suggested as desirable antibiotic alternatives to pigs by improving gut health and growth performance. However, limited studies of the effectiveness of E. faecium in weaning pigs, the objective of this study was to investigate the effects of E. faecium DSM 7134 supplementation on growth performance, nutrient digestibility, antioxidant parameters, volatile fatty acids concentration, intestinal histomorphology, and diarrhea score in weaning pig. RESULTS: E...
April 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28399166/ultraviolet-uv-c-inactivation-of-enterococcus-faecium-salmonella-choleraesuis-and-salmonella-typhimurium-in-porcine-plasma
#13
Elena Blázquez, Carmen Rodríguez, Jesús Ródenas, Ana Pérez de Rozas, Joaquim Segalés, Joan Pujols, Javier Polo
The objective of this study was to assess the effectiveness of an ultraviolet (UV-C, 254 nm) irradiation system on reducing the load of Salmonella typhimurium (S. typhimurium), Salmonella choleraesuis (S. choleraesuis) resistant to streptomycin and Enterococcus faecium (E. faecium) inoculated in sterile porcine plasma and then subjected to different UV-C irradiation doses (750, 1500, 3000, 6000 and 9000 J/L) using a pilot plant UV-C device working under turbulent flow. Results indicated that UV-C treatment induced a viability reduction of 0...
2017: PloS One
https://www.readbyqxmd.com/read/28397040/bloodstream-infections-caused-by-enterococcus-spp-a-10-year-retrospective-analysis-at-a-tertiary-hospital-in-china
#14
Jin-Xin Zheng, Hui Li, Zhang-Ya Pu, Hong-Yan Wang, Xiang-Bin Deng, Xiao-Jun Liu, Qi-Wen Deng, Zhi-Jian Yu
In order to discover the risk factors for 30-day mortality in bloodstream infections (BSI) caused by Enterococcus spp. strains, we explored the clinical and therapeutic profile of patients with Enterococcus spp. BSI and the characteristics of this condition. A total of 64 patients with BSI caused by Enterococcus spp. who were treated in our hospital between 2006 and 2015 were included in the study. The clinical features of patients, microbiology, and 30-day mortality were collected from the electronic medical records database and analyzed...
April 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28389190/detection-of-vancomycin-resistant-enterococci-vre-in-stool-specimens-submitted-for-clostridium-difficile-toxin-testing
#15
Sevim Özsoy, Arzu İlki
The aim of this study was to determine the association between Clostridium difficile (C. difficile) and vancomycin-resistant Enterococcus (VRE) and efficacy of screening stools submitted for C. difficile toxin assay for prevalence of VRE. Between April 2012 and February 2014, 158 stool samples submitted for C. difficile toxin to the Marmara University Microbiology Laboratory, were included in the study. Stool samples were analyzed by enzyme immuno assay test; VIDAS (bioMerieux, France) for Toxin A&B. Samples were inoculated on chromID VRE (bioMerieux, France) and incubated 24h at 37°C...
March 17, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28385565/a-10-year-profile-of-enterococcal-bloodstream-infections-at-a-tertiary-care-hospital-in-japan
#16
Hiroyuki Suzuki, Ryota Hase, Yoshihito Otsuka, Naoto Hosokawa
OBJECTIVES: The first aim of this study is to characterize the epidemiology of enterococcal bloodstream infections (BSIs) at a Japanese tertiary-care hospital. The second aim is to identify predictive factors for 30-day mortality. METHODS: We conducted a single center retrospective observational study. All patients with enterococcal BSI between 2005 and 2014 were enrolled. Univariate and multivariate analysis were performed to evaluate predictive factors for 30-day mortality...
April 3, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28385464/microbiology-of-surgical-site-infections-in-patients-with-cancer-a-7-year-review
#17
Juan Carlos Hernaiz-Leonardo, Maria Fernanda Golzarri, Patricia Cornejo-Juárez, Patricia Volkow, Consuelo Velázquez, Mauricio Ostrosky-Frid, Diana Vilar-Compte
BACKGROUND: Health care-associated infections (HAIs) have arisen as major sources of multidrug-resistant bacteria. Surgical site infections (SSIs) are the most frequent HAIs in many countries, with high antimicrobial-resistant prevalence. METHODS: A 7-year retrospective review (2008-2014) of microbiologic data within a prospective surveillance program on patients with SSI at a cancer hospital in Mexico. RESULTS: There were 23,421 surgeries performed during the study period...
April 3, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28378583/iodinated-meroditerpenes-from-a-red-alga-callophycus-sp
#18
Serge Lavoie, David Brumley, Troy S Alexander, Christine Jasmin, Franz A Carranza, Kate Nelson, Cassandra L Quave, Julia Kubanek
Unique iodine-containing meroditerpenes iodocallophycoic acid A (1) and iodocallophycols A-D (2-5) were discovered from the Fijian red alga Callophycus sp. Because flexibility of the molecular skeleton impaired full characterization of relative stereochemistries by NMR spectroscopy, a DFT-based theoretical model was developed to derive relevant interproton distances which were compared to those calculated from NOE measurements, yielding the relative stereochemistries. The correct 2S,6S,7S,10S,14S enantiomers were then identified by comparison of theoretical and experimental ECD spectra...
April 13, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28375806/microbiomic-analysis-of-intra-abdominal-infections-by-using-denaturing-high-performance-liquid-chromatography-a-prospective-observational-study
#19
Christian Koch, Anca L Amati, Andreas Hecker, Marcel Höxter, Marcus Hirschburger, Reginald Matejec, Winfried Padberg, Marcus A Weigand, Christoph Lichtenstern, Eugen Domann
BACKGROUND: Intra-abdominal infections represent a subgroup of septic syndromes with high death rates and the need for prompt and appropriate antimicrobial therapy. Conventional culture-based microbial identification has notable shortcomings in the diagnostics of polymicrobial infections. Modern culture-independent molecular methods may represent a new diagnostic approach. The current study aimed to compare the results obtained from the denaturing high-performance liquid chromatography WAVE(®) system as a culture-independent diagnostic tool with those obtained from standard culture-based microbiologic testing in the clinical setting of severe intra-abdominal sepsis...
April 4, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28371348/quaternized-and-thiazole-functionalized-free-radical-generating-organometallic-dendrimers-as-antimicrobial-platform-against-multidrug-resistant-microorganisms
#20
Alaa S Abd-El-Aziz, Christian Agatemor, Nola Etkin, Rabin Bissessur, David Overy, Martin Lanteigne, Katherine McQuillan, Russell G Kerr
New macromolecules such as dendrimers are increasingly needed to drive breakthroughs in diverse areas, for example, healthcare. Here, the authors report hybrid antimicrobial dendrimers synthesized by functionalizing organometallic dendrimers with quaternary ammonium groups or 2-mercaptobenzothiazole. The functionalization tunes the glass transition temperature and antimicrobial activities of the dendrimers. Electron paramagnetic resonance spectroscopy reveals that the dendrimers form free radicals, which have significant implications for catalysis and biology...
March 31, 2017: Macromolecular Bioscience
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