keyword
https://read.qxmd.com/read/38547217/factors-related-to-a-sense-of-economic-insecurity-among-older-adults-who-participate-in-social-activities
#21
JOURNAL ARTICLE
Yuriko Inoue, Hisae Nakatani, Ichie Ono, Xuxin Peng
Japan has the highest life expectancy worldwide. Older adults who experience economic insecurity may refrain from seeking medical consultation or using long-term care insurance, and these behaviors may increase the incidence and progression of frailty. This study conducted a cross-sectional survey to identify factors related to a sense of economic insecurity among older adults who participate in social activities, and identified support measures. In total, 1,351 older adults aged ≥65 years who had participated in social activities voluntarily completed an anonymous self-administered questionnaire...
2024: PloS One
https://read.qxmd.com/read/38547208/metabolomic-response-to-acute-resistance-exercise-in-healthy-older-adults-by-1h-nmr
#22
JOURNAL ARTICLE
Darya Moosavi, Ivan Vuckovic, Hawley E Kunz, Ian R Lanza
BACKGROUND: The favorable health-promoting adaptations to exercise result from cumulative responses to individual bouts of physical activity. Older adults often exhibit anabolic resistance; a phenomenon whereby the anabolic responses to exercise and nutrition are attenuated in skeletal muscle. The mechanisms contributing to age-related anabolic resistance are emerging, but our understanding of how chronological age influences responsiveness to exercise is incomplete. The objective was to determine the effects of healthy aging on peripheral blood metabolomic response to a single bout of resistance exercise and whether any metabolites in circulation are predictive of anabolic response in skeletal muscle...
2024: PloS One
https://read.qxmd.com/read/38547186/reflected-generalized-concentration-addition-and-bayesian-hierarchical-models-to-improve-chemical-mixture-prediction
#23
JOURNAL ARTICLE
Daniel Zilber, Kyle Messier
Environmental toxicants overwhelmingly occur together as mixtures. The variety of possible chemical interactions makes it difficult to predict the danger of the mixture. In this work, we propose the novel Reflected Generalized Concentration Addition (RGCA), a piece-wise, geometric technique for sigmoidal dose-responsed inverse functions that extends the use of generalized concentration addition (GCA) for 3+ parameter models. Since experimental tests of all relevant mixtures is costly and intractable, we rely only on the individual chemical dose responses...
2024: PloS One
https://read.qxmd.com/read/38547150/transfer-learning-from-rating-prediction-to-top-k-recommendation
#24
JOURNAL ARTICLE
Fan Ye, Xiaobo Lu, Hongwei Li, Zhenyu Chen
Recommender system has made great strides in two major research fields, rating prediction and Top-k recommendation. In essence, rating prediction is a regression task, which aims to predict users scores on other items, while Top-k is a classification task selecting the items that users have the most potential to interact with. Both characterize users and items, but the optimization of parameters varies widely for their respective tasks. Inspired by the idea of transfer learning, we consider extracting the information learned from rating prediction models for serving for Top-k tasks...
2024: PloS One
https://read.qxmd.com/read/38547142/a-realistic-mixture-of-ubiquitous-persistent-organic-pollutants-affects-bone-and-cartilage-development-in-zebrafish-by-interaction-with-nuclear-receptor-signaling
#25
JOURNAL ARTICLE
Gustavo Guerrero-Limón, Jérémie Zappia, Marc Muller
"Persistent organic pollutants (POPs)" have a plethora of deleterious effects on humans and the environment due to their bioaccumulative, persistent, and mimicking properties. Individually, each of these chemicals has been tested and its effects measured, however they are rather found as parts of complex mixtures of which we do not fully grasp the extent of their potential consequences. Here we studied the effects of realistic, environmentally relevant mixtures of 29 POPs on cartilage and bone development using zebrafish as a model species...
2024: PloS One
https://read.qxmd.com/read/38547140/high-breakthrough-pressure-in-hydrogels-enabled-ultrastable-treatment-of-hypersaline-wastewaters
#26
JOURNAL ARTICLE
Yanni Ma, Zehua Yu, Xifan Fu, Tenghui Qiu, Na Zhao, Huidong Liu, Zhi Huang, Kang Liu
Surface effects of low-surface-tension contaminants accumulating at the evaporation surface easily induce wetting in membrane distillation, especially in hypersaline scenarios. Herein, we propose a novel strategy to eliminate the surface effect and redistribute contaminants at the evaporation interface simply by incorporating a layer of hydrogel. The as-fabricated composite membrane exhibits remarkable stability, even when exposed to solution with salt concentration of 5 M and surfactant concentration of 8 mM...
March 28, 2024: Nano Letters
https://read.qxmd.com/read/38547137/balancing-the-uncertain-and-unpredictable-nature-of-possible-zoonotic-disease-transmission-with-the-value-placed-on-animals-findings-from-a-qualitative-study-in-guinea
#27
JOURNAL ARTICLE
Tilly A Gurman, Kendela Diallo, Elizabeth Larson, Kathryn Sugg, Natalie Tibbels
Zoonoses, or diseases that pass between animals and humans, represent a major threat to global health and global economies. In Guinea, zoonotic diseases (e.g. rabies, Lassa fever) have been at the forefront due to recent outbreaks and government priorities. Much like many other diseases, zoonotic disease prevention demands a thorough and culturally nuanced understanding of the factors that influence preventive behaviors. To gain this knowledge and enhance risk communication for priority zoonotic diseases, this qualitative study conducted focus group discussions, in-depth interviews, and observations in three Guinean prefectures...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38547135/the-vertigo-trial-protocol-a-prospective-single-center-patient-blinded-study-to-evaluate-efficacy-and-safety-of-prolonged-daily-stimulation-with-a-multichannel-vestibulocochlear-implant-prototype-in-bilateral-vestibulopathy-patients
#28
JOURNAL ARTICLE
Bernd L Vermorken, Benjamin Volpe, Stan C J van Boxel, Joost J A Stultiens, Marc van Hoof, Rik Marcellis, Elke Loos, Alexander van Soest, Chris McCrum, Kenneth Meijer, Nils Guinand, Angélica Pérez Fornos, Vincent van Rompaey, Elke Devocht, Raymond van de Berg
BACKGROUND: A combined vestibular (VI) and cochlear implant (CI) device, also known as the vestibulocochlear implant (VCI), was previously developed to restore both vestibular and auditory function. A new refined prototype is currently being investigated. This prototype allows for concurrent multichannel vestibular and cochlear stimulation. Although recent studies showed that VCI stimulation enables compensatory eye, body and neck movements, the constraints in these acute study designs prevent them from creating more general statements over time...
2024: PloS One
https://read.qxmd.com/read/38547116/tobacco-use-among-in-school-young-adolescents-in-indonesia-exploring-availability-affordability-and-accessibility
#29
JOURNAL ARTICLE
Yeni Rosilawati, Zain Rafique, Erwan Sudiwijaya
The research on Indonesian adolescents' perception of tobacco control in schools is limited. This study aimed to explore the availability, affordability, and accessibility of tobacco among young adolescents in Yogyakarta Municipality, Indonesia, with a focus on advocating for school teenagers. Focus groups, comprising participants from diverse backgrounds and stakeholders, were conducted in Yogyakarta, Indonesia, to systematically collect varied data. The subsequent analysis employed a robust thematic approach, combining both inductive and deductive processes to ensure a nuanced exploration of emerging patterns and pre-existing frameworks...
2024: PloS One
https://read.qxmd.com/read/38547114/attentional-cueing-gaze-is-harder-to-override-than-arrows
#30
JOURNAL ARTICLE
Inka Schmitz, Hanna Strauss, Ludwig Reinel, Wolfgang Einhäuser
Gaze is an important and potent social cue to direct others' attention towards specific locations. However, in many situations, directional symbols, like arrows, fulfill a similar purpose. Motivated by the overarching question how artificial systems can effectively communicate directional information, we conducted two cueing experiments. In both experiments, participants were asked to identify peripheral targets appearing on the screen and respond to them as quickly as possible by a button press. Prior to the appearance of the target, a cue was presented in the center of the screen...
2024: PloS One
https://read.qxmd.com/read/38547104/the-effect-of-cooperator-recognition-on-competition-among-clones-in-spatially-structured-microbial-communities
#31
JOURNAL ARTICLE
Adrienna Bingham, Aparajita Sur, Leah B Shaw, Helen A Murphy
In spatially structured microbial communities, clonal growth of stationary cells passively generates clusters of related individuals. This can lead to stable cooperation without the need for recognition mechanisms. However, recent research suggests that some biofilm-forming microbes may have mechanisms of kin recognition. To explore this unexpected observation, we studied the effects of different types of cooperation in a microbial colony using spatially explicit, agent-based simulations of two interacting strains...
2024: PloS One
https://read.qxmd.com/read/38547101/behind-the-scenes-centromere-driven-genomic-innovations-in-fungal-pathogens
#32
JOURNAL ARTICLE
Aswathy Narayanan, Md Hashim Reza, Kaustuv Sanyal
No abstract text is available yet for this article.
March 2024: PLoS Pathogens
https://read.qxmd.com/read/38547061/the-%C3%AE-2-adrenergic-receptor-associates-with-cxcr4-multimers-in-human-cancer-cells
#33
JOURNAL ARTICLE
Junyi Liang, Mohamed Seghiri, Pradeep Kumar Singh, Hyeon Gyu Seo, Ji Yeong Lee, Yoonjung Jo, Yong Bhum Song, Chulo Park, Piotr Zalicki, Jae-Yeon Jeong, Won-Ki Huh, Niña G Caculitan, Adam W Smith
While the existence and functional role of class C G-protein-coupled receptors (GPCR) dimers is well established, there is still a lack of consensus regarding class A and B GPCR multimerization. This lack of consensus is largely due to the inherent challenges of demonstrating the presence of multimeric receptor complexes in a physiologically relevant cellular context. The C-X-C motif chemokine receptor 4 (CXCR4) is a class A GPCR that is a promising target of anticancer therapy. Here, we investigated the potential of CXCR4 to form multimeric complexes with other GPCRs and characterized the relative size of the complexes in a live-cell environment...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38547058/nsun5-tet2-directed-chromatin-associated-rna-modification-of-5-methylcytosine-to-5-hydroxymethylcytosine-governs-glioma-immune-evasion
#34
JOURNAL ARTICLE
Ruixin Wu, Chunming Sun, Xi Chen, Runyue Yang, Yuxuan Luan, Xiang Zhao, Panpan Yu, Rongkui Luo, Yingyong Hou, Ruotong Tian, Shasha Bian, Yuli Li, Yinghua Dong, Qian Liu, Weiwei Dai, Zhuoyang Fan, Rucheng Yan, Binyang Pan, Siheng Feng, Jing Wu, Fangzhen Chen, Changle Yang, Hanlin Wang, Haochen Dai, Minfeng Shu
Malignant glioma exhibits immune evasion characterized by highly expressing the immune checkpoint CD47. RNA 5-methylcytosine(m5C) modification plays a pivotal role in tumor pathogenesis. However, the mechanism underlying m5C-modified RNA metabolism remains unclear, as does the contribution of m5C-modified RNA to the glioma immune microenvironment. In this study, we demonstrate that the canonical 28SrRNA methyltransferase NSUN5 down-regulates β-catenin by promoting the degradation of its mRNA, leading to enhanced phagocytosis of tumor-associated macrophages (TAMs)...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38547044/construction-and-analysis-of-a-network-of-exercise-induced-mitochondria-related-non-coding-rna-in-the-regulation-of-diabetic-cardiomyopathy
#35
JOURNAL ARTICLE
Shuo Wang, Jiacong Li, Yungang Zhao
Diabetic cardiomyopathy (DCM) is a major factor in the development of heart failure. Mitochondria play a crucial role in regulating insulin resistance, oxidative stress, and inflammation, which affect the progression of DCM. Regular exercise can induce altered non-coding RNA (ncRNA) expression, which subsequently affects gene expression and protein function. The mechanism of exercise-induced mitochondrial-related non-coding RNA network in the regulation of DCM remains unclear. This study seeks to construct an innovative exercise-induced mitochondrial-related ncRNA network...
2024: PloS One
https://read.qxmd.com/read/38547008/the-importance-of-individual-beliefs-in-assessing-treatment-efficacy
#36
JOURNAL ARTICLE
Luisa Fassi, Shachar Hochman, Zafiris J Daskalakis, Daniel M Blumberger, Roi Cohen Kadosh
In recent years, there has been debate about the effectiveness of treatments from different fields, such as neurostimulation, neurofeedback, brain training, and pharmacotherapy. This debate has been fuelled by contradictory and nuanced experimental findings. Notably, the effectiveness of a given treatment is commonly evaluated by comparing the effect of the active treatment versus the placebo on human health and/or behaviour. However, this approach neglects the individual's subjective experience of the type of treatment she or he received in establishing treatment efficacy...
March 28, 2024: ELife
https://read.qxmd.com/read/38546994/knowledge-augmented-visual-question-answering-with-natural-language-explanation
#37
JOURNAL ARTICLE
Jiayuan Xie, Yi Cai, Jiali Chen, Ruohang Xu, Jiexin Wang, Qing Li
Visual question answering with natural language explanation (VQA-NLE) is a challenging task that requires models to not only generate accurate answers but also to provide explanations that justify the relevant decision-making processes. This task is accomplished by generating natural language sentences based on the given question-image pair. However, existing methods often struggle to ensure consistency between the answers and explanations due to their disregard of the crucial interactions between these factors...
March 28, 2024: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://read.qxmd.com/read/38546989/adaptiveclick-click-aware-transformer-with-adaptive-focal-loss-for-interactive-image-segmentation
#38
JOURNAL ARTICLE
Jiacheng Lin, Jiajun Chen, Kailun Yang, Alina Roitberg, Siyu Li, Zhiyong Li, Shutao Li
Interactive image segmentation (IIS) has emerged as a promising technique for decreasing annotation time. Substantial progress has been made in pre-and post-processing for IIS, but the critical issue of interaction ambiguity, notably hindering segmentation quality, has been under-researched. To address this, we introduce AdaptiveClick - a click-aware transformer incorporating an adaptive focal loss (AFL) that tackles annotation inconsistencies with tools for mask-and pixel-level ambiguity resolution. To the best of our knowledge, AdaptiveClick is the first transformer-based, mask-adaptive segmentation framework for IIS...
March 28, 2024: IEEE Transactions on Neural Networks and Learning Systems
https://read.qxmd.com/read/38546978/role-of-kcnk3-dysfunction-in-dasatinib-associated-pah-and-endothelial-cell-dysfunction
#39
JOURNAL ARTICLE
Hélène Le Ribeuz, Anaïs Saint-Martin Willer, Benoit Chevalier, Maria Sancho, Bastien Masson, Mélanie Eyries, Vincent Jung, Ida Chiara Guerrera, Mary Dutheil, Kristelle El Jekmek, Loann Laubry, Gilles Carpentier, Francisco Perez-Vizcaino, Ly Tu, Christophe Guignabert, Marie-Camille Chaumais, Christine Péchoux, Marc Humbert, Alexandre Hinzpeter, Olaf Mercier, Véronique Capuano, David Montani, Fabrice Antigny
Pulmonary arterial hypertension (PAH) is severe cardiopulmonary disease that may be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions. The incidence of dasatinib-associated PAH is estimated at 0.45%, suggesting individual predispositions. The mechanisms of dasatinib-associated PAH are still incomplete. We discovered a KCNK3 gene (coding for outward K+ channel) variant in a patient with dasatinib-associated PAH, and we investigated the impact of this variant on KCNK3 function...
March 28, 2024: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/38546977/multiscale-computational-framework-for-the-liquid-liquid-phase-separation-of-intrinsically-disordered-proteins
#40
JOURNAL ARTICLE
Kalindu S Fernando, Ghodsiehsadat Jahanmir, Ilona C Unarta, Ying Chau
The reversible assembly of intrinsically disordered proteins (IDPs) to form membraneless organelles (MLOs) is a fundamental process involved in the spatiotemporal regulation in living cells. MLOs formed via liquid-liquid phase separation (LLPS) serve as molecule-enhancing hubs to regulate cell functions. Owing to the complexity and dynamic nature of the protein assembly via a network of weak inter- and intra-molecular interactions, it is challenging to describe and predict the LLPS behavior. We have developed a multiscale computational model for IDPs, using the fused in sarcoma (FUS) protein and its variants as illustrative examples...
March 28, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
keyword
keyword
66751
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.