keyword
MENU ▼
Read by QxMD icon Read
search

nuclear factor kB

keyword
https://www.readbyqxmd.com/read/28912082/mapk-signalling-pathway-in-cancers-olive-products-as-cancer-preventive-and-therapeutic-agents
#1
REVIEW
Ilaria Peluso, Nagendra Sastry Yarla, Roberto Ambra, Gianni Pastore, George Perry
The mitogen-activated protein kinases (MAPKs) are fundamental in inflammation and cancer control, through the crosstalk between the redox regulated nuclear factor E2-related factor 2 (Nrf2) and nuclear factor-kB (NFκB) gene expression. MAPKs regulate various cellular activities involved in cancer progression, including proliferation, apoptosis and immune escape and blockade of upstream kinases is a current therapeutic strategy. However, these therapies are associated with some adverse effects and with the paradoxical activation of the MAPKs pathway...
September 11, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28904316/assessment-of-local-and-systemic-25-hydroxy-vitamin-d-rankl-opg-and-tnf-levels-in-patients-with-rheumatoid-arthritis-and-periodontitis
#2
Hatice Balci Yuce, Ozge Gokturk, Humeyra Aydemir Turkal, Ahmet Inanir, Ismail Benli, Osman Demir
The present study aimed to evaluate proinflammatory cytokine and vitamin D levels in rheumatoid arthritis (RA) and chronic periodontitis (CP) patients and healthy individuals before and after initial periodontal treatment. Overall, 17 CP patients with RA (RA + CP), 18 systemically healthy CP patients (CP), and 18 healthy controls (C) were included. Clinical periodontal measurements were recorded and gingival crevicular fluid (GCF) and blood samples were recorded. RA + CP and CP patients received nonsurgical periodontal treatment...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28901327/selective-lesioning-of-nuclear-factor-kb-activated-cells-in-the-nucleus-accumbens-shell-attenuates-alcohol-place-preference
#3
S E Nennig, H D Fulenwider, S H Chimberoff, B M Smith, J E Eskew, M K Sequeira, C Karlsson, C Liang, J Chen, M Heilig, J R Schank
Nuclear factor κ light chain enhancer of activated B cells (NFkB) is a transcription factor commonly associated with innate immunity, and is activated by infection and inflammation. NFkB has recently gained attention as a mediator of complex psychiatric phenomena like stress and addiction. In regards to alcohol, most research on NFkB has focused on neurotoxicity, and few studies have explored the role of NFkB in alcohol reward, reinforcement, or consumption. In these studies, we used conditioned place preference to assess the activity of NFkB in response to rewarding doses of alcohol...
September 13, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28891223/promoter-architecture-and-transcriptional-regulation-of-musculoskeletal-embryonic-nuclear-protein-1b-mustn1b-gene-in-zebrafish
#4
P Suarez-Bregua, C J Chien, M Megias, S D Du, J Rotllant
BACKGROUND: Mustn1 is a specific musculoskeletal protein that plays a critical role in myogenesis and chondrogenesis in vertebrates. Whole-mount in situ hybridization revealed that mustn1b mRNAs are specifically expressed in skeletal and cardiac muscles in zebrafish embryos. However, the precise function and the regulatory elements required for its muscle-specific expression are largely unknown. RESULTS: The purpose of this study was to explore and uncover the target genomic regions that regulate mustn1b gene expression by in-vivo functional characterization of the mustn1b promoter...
September 11, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28890293/epidermal-barrier-reaction-to-an-in-vitro-psoriatic-microenvironment
#5
Elena Donetti, Laura Cornaghi, Francesca Arnaboldi, Federica Ricceri, Leonardo Pescitelli, Martina Maiocchi, Francesco Carriero, Franz Baruffaldi Preis, Francesca Prignano
Keratinocytes (KCs) and Langerhans cells (LCs) contribute to create the epidermal barrier. To form a functional epidermis, KCs express filaggrin and Toll-like Receptors (TLRs). LCs are the first line of epidermal defence and can be activated by interleukin (IL)-17 and Tumor Necrosis Factor (TNF)-alpha. In psoriasis, an alteration of TLR expression, a defective expression of filaggrin, and LC activation occur. In organotypic cultures of human skin we investigated the interplay between IL-17 and TNF-alpha on i) expression of filaggrin, TLR2, 7 and 9, and Nuclear Factor (NF)-kB localization by immunofluorescence and ii) LC ultrastructural features by transmission electron microscopy...
September 7, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28868036/baicalin-alleviates-lipopolysaccharide-induced-liver-inflammation-in-chicken-by-suppressing-tlr4-mediated-nf-%C3%AE%C2%BAb-pathway
#6
Ping Cheng, Tong Wang, Wei Li, Ishfaq Muhammad, He Wang, Xiaoqi Sun, Yuqi Yang, Jiarui Li, Tianshi Xiao, Xiuying Zhang
As a kind of potent stimulus, lipopolysaccharide (LPS) has the ability to cause cell damage by activating toll-like receptor(TLR)4, then nuclear factor kappa B (NF-κB) translocates into the nucleus and changes the expression of related inflammatory genes. Baicalin is extracted from Radix Scutellariae, which possesses anti-inflammation, antioxidant and antibacterial properties. However, the effects of it on LPS-induced liver inflammation have not been fully elucidated. This study aims to investigate the anti-inflammatory effects of Baicalin on the LPS-induced liver inflammation and its underlying molecular mechanisms in chicken...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28867452/the-role-of-osteoprotegerin-in-the-crosstalk-between-vessels-and-bone-its-potential-utility-as-a-marker-of-cardiometabolic-diseases
#7
REVIEW
Luc Rochette, Alexandre Meloux, Eve Rigal, Marianne Zeller, Yves Cottin, Catherine Vergely
Among the numerous molecules that are being studied for their potential utility as biomarkers of cardiovascular diseases, much interest has been shown in the superfamily of tumor necrosis factor (TNF) receptors. Members of this family include osteoprotegerin (OPG) and its ligands, which are receptor activators of nuclear factor κB ligand (RANKL) and TNF-related apoptosis-inducing ligand (TRAIL). These signals may be expressed and regulated, and their functions could be involved in several physiological and pathological processes...
September 1, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28865081/chronic-treatment-with-zoledronic-acid-increases-inflammatory-markers-in-periodontium-of-rats
#8
Paulo Goberlânio de Barros Silva, Antonio Ernando Carlos Ferreira Junior, Camila Carvalho de Oliveira, Luiz André Cavalcante Brizeno, Deysi Viviana Tenazoa Wong, Roberto César Pereira Lima Júnior, Fabrício Bitú Sousa, Mário Rogério Lima Mota, Ana Paula Negreiros Nunes Alves
BACKGROUND: Bisphosphonates (BF) rises proinflammatory markers and irreversibly binds to bone. Chronically BF can lead to an inflammatory status and can increase the local oxidative stress in periodontium. Therefore, the objective of this study was evaluated if the chronic infusion of Zoledronic Acid (ZA) increases inflammatory markers in periodontium of rats. METHODS AND RESULTS: Chronically infusion therapy was performed with ZA (0.04, 0.2 or 1 mg/kg or saline) by four doses in over a 70-day period to analysis periodontium of the first right inferior molar using histologic, histochemical (toluidine blue) and immunohistochemical (CD68, Tumor Necrosis Factor-α (TNF-α), Interleukin-1beta (IL-1β), Inducible Nitric Oxide Synthase (iNOS) and Nuclear Factor kappa B (NF-kB)) tests...
September 2, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28858724/alpha-mangostin-protects-rat-articular-chondrocytes-against-il-1%C3%AE-induced-inflammation-and-slows-the-progression-of-osteoarthritis-in-a-rat-model
#9
Tianlong Pan, Dengying Wu, Ningyu Cai, Rong Chen, Xuchao Shi, Bin Li, Jun Pan
Osteoarthritis (OA) is a joint disease characterized by inflammation and cartilage degradation. α-Mangostin (α-MG), which can be isolated from the fruit of the tropical evergreen tree Garcinia mangostana-L, is known to have anti-inflammatory properties. The aim of the study was to investigate the use of α-MG in the treatment of OA, using both rat chondrocytes and an OA rat model induced by destabilization of the medial meniscus (DMM). Rat chondrocytes were pretreated with α-MG (0, 1.25, 2.5, and 5.0μg/ml for 24h) prior to stimulation with interleukin-1β (IL-1β) (10ng/ml for 24h)...
August 28, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28856536/interleukin-8-and-nuclear-factor-kappa-b-are-increased-and-positively-correlated-in-myelodysplastic-syndrome
#10
Anacélia Gomes de Matos, Howard Lopes Ribeiro Junior, Daniela de Paula Borges, Bruno Memória Okubo, Juliana Cordeiro de Sousa, Maritza Cavalcante Barbosa, Marilena Facundo de Castro, Romélia Pinheiro Gonçalves, Ronald Feitosa Pinheiro, Silvia Maria Meira Magalhães
The pathogenesis of myelodysplastic syndromes (MDS) is complex and depends on the interaction between aberrant hematopoietic cells and their microenvironment, probably including aberrations in cytokines and their signaling pathways. To evaluate interleukin-8 (IL-8) plasma levels and nuclear factor kappa B (NF-kB) in patients with MDS and to test possible correlation between IL-8 and NF-Kb, a total of 45 individuals were analyzed: 25 consecutive adult de novo MDS patients and 20 sex and age-matched healthy elderly volunteers...
August 30, 2017: Medical Oncology
https://www.readbyqxmd.com/read/28844606/ampk-activation-role-in-the-signaling-pathways-of-neuroinflammation-and-neurodegeneration
#11
REVIEW
Christina Alves Peixoto, Wilma Helena de Oliveira, Shyrlene Meiry da Racho Araújo, Ana Karolina Santana Nunes
Adenosine monophosphate-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular energy status and has been reported to be involved in chronic inflammatory disorders. AMPK is expressed in immune cells, such as dendritic cells, macrophages, lymphocytes and neutrophils, and is an important regulator of inflammatory responses through the regulation of complex signaling networks in part by inhibiting downstream cascade pathways, such as nuclear factor kB, which is a key regulator of innate immunity and inflammation, as well as acting as a negative regulator of toll-like receptors...
August 24, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28840846/tumour-necrosis-factor-alpha-and-nuclear-factor-kappa-b-gene-variants-in-sepsis
#12
Leyla Acar, Nazan Atalan, E Hande Karagedik, Arzu Ergen
BACKGROUND: Humoral system is activated and various cytokines are released due to infections in tissues and traumatic damage. NF-kB dimers are encoded by NF-kB genes and regulate transcription of several crucial proteins of inflammation such as tumour necrosis factor-alpha (TNFα). AIMS: To investigate the possible effect of polymorphisms on TNFα serum levels with clinical and prognostic parameters of sepsis by determining the NF-kB1 -94 ins/del ATTG and TNFα (-308 G/A) gene polymorphisms and TNFα serum levels...
August 25, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28827109/chromofungin-chr-chga47-66-is-downregulated-in-persons-with-active-ulcerative-colitis-and-suppresses-pro-inflammatory-macrophage-function-through-the-inhibition-of-nf-%C3%AE%C2%BAb-signaling
#13
Nour Eissa, Hayam Hussein, Laëtitia Kermarrec, Omar Elgazzar, Marie-Helene Metz-Boutigue, Charles N Bernstein, Jean-Eric Ghia
Chromogranin-A (CHGA) is a prohormone secreted by neuroendocrine cells and is a precursor of several bioactive peptides, which are implicated in different and distinctive biological and immune functions. Chromofungin (CHR: CHGA47-66) is a short peptide with antimicrobial effects and encodes from CHGA exon-IV. Inflammatory bowel disease (IBD) is characterized by alterations in the activation of pro-inflammatory pathways, pro-inflammatory macrophages (M1), and nuclear transcription factor kappa B (NF-κB) signaling leading to the perpetuation of the inflammatory process...
August 19, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28813782/urea-cycle-pathway-targeted-therapeutic-action-of-naringin-against-ammonium-chloride-induced-hyperammonemic-rats
#14
Arumugam Ramakrishnan, Natesan Vijayakumar
Ammonia is a well-known neurotoxin that causes liver disease and urea cycle disorder. Excessive ammonia content in the blood leads to hyperammonemic condition and affects both excitatory and inhibitory neurotransmission including brain edema and coma. Naringin, a plant bioflavonoid present in various citrus fruits and mainly extracted from the grape fruit. This study was designed to assess the protective effect of naringin on ammonium chloride (NH4Cl) induced hyperammonemic rats. Experimental hyperammonemia was induced by intraperitoneal injections (i...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28808377/anti-inflammatory-potential-of-petiveria-alliacea-on-activated-raw264-7-murine-macrophages
#15
Rosa Martha Perez Gutierrez, Carlos Hoyo-Vadillo
BACKGROUND: Defense and protection to multiple harmful stimuli are the inflammation, when is self-amplified and uncontrolled is the basis of the pathogenesis of a wide variety of inflammatory illness. The aim of this study was to evaluate if Petiveria alliacea could attenuate inflammation in a murine model of RAW264 macrophages the involved model and its involved mechanism. MATERIALS AND METHODS: The ethanol extract from P. alliacea was precipitated with water and supernatant was used for this study (PW)...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28803264/hyaluronan-in-the-experimental-injury-of-the-cartilage-biochemical-action-and-protective-effects
#16
REVIEW
Angela Avenoso, Angela D'Ascola, Michele Scuruchi, Giuseppe Mandraffino, Alberto Calatroni, Antonino Saitta, Salvatore Campo, Giuseppe M Campo
INTRODUCTION: Our knowledge of extracellular matrix (ECM) structure and function has increased enormously over the last decade or so. There is evidence demonstrating that ECM provides signals affecting cell adhesion, shape, migration, proliferation, survival, and differentiation. ECM presents many domains that become active after proteolytic cleavage. These active ECM fragments are called matrikines which play different roles; in particular, they may act as potent inflammatory mediators during cartilage injury...
August 12, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28791733/incontinentia-pigmenti-in-a-male-xy-infant-with-long-term-follow-up-over-8-years
#17
Yasushi Matsuzaki, Akiko Rokunohe, Satoko Minakawa, Kazuo Nomura, Hajime Nakano, Etsuro Ito, Daisuke Sawamura
Incontinentia pigmenti (IP) is an X-linked genodermatosis affecting the skin and other sites, including the teeth, nails, hair, eyes and nervous system defects in female patients. Generally lethal in males, there are only a few known cases of males surviving this condition. Nuclear factor (NF)-κB essential modulator (NEMO), also known as inhibitor of kappa light polypeptide gene enhancer in B cells, kinase gamma (IKBKG), constitutes an essential activator of NF-κB. Over 80% of female patients with IP carry a common deletion mutation involving exons 4-10 of the IKBKG/NEMO gene...
August 9, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28790925/nlrp3-inflammasome-as-a-molecular-marker-in-diabetic-cardiomyopathy
#18
REVIEW
Beibei Luo, Feng Huang, Yanli Liu, Yiying Liang, Zhe Wei, Honghong Ke, Zhiyu Zeng, Weiqiang Huang, Yan He
Diabetic cardiomyopathy (DCM), a common consequence of longstanding diabetes mellitus, is initiated by death of cardiomyocyte. Hyperglycemia-induced reactive oxygen species (ROS) overproduction is a major contributor of the chronic low-grade inflammation that characterizes as the DCM. ROS may promote the activation of nucleotide-binding oligomerization domain like receptor (NLR) pyrin domain containing 3 (NLRP3) inflammasome, a novel regulator of inflammation and cell death, by nuclear factor-kB (NF-κB) and thioredoxin interacting/inhibiting protein (TXNIP)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28748903/immunoglobulin-a-nephropathy-in-a-patient-with-igg-kappa-light-chain-myeloma
#19
Abhilash Chandra, Anupama Kaul, Vinita Aggarwal
Paraproteins can cause a variable set of pathologic changes in the kidney. The introduction of novel anti-plasma cell agents capable of reversing renal failure have revolutionized the management of paraprotein-mediated kidney injury. Activation of the transcription factor nuclear factor kB (NF-kB) has been shown to be involved in the development of human glomerulonephritis (GN). Inhibitors of NF-kB may provide potential agents for treatment of immune complex GN. In this paper, we report a patient with IgA nephropathy and IgG kappa myeloma, who responded dramatically to chemotherapy targeted toward myeloma...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28739185/novel-atherogenic-pathways-from-the-differential-transcriptome-analysis-of-diabetic-epicardial-adipose-tissue
#20
COMPARATIVE STUDY
V Camarena, D Sant, M Mohseni, T Salerno, M L Zaleski, G Wang, G Iacobellis
BACKGROUND AND AIM: To evaluate the epicardial adipose tissue (EAT) transcriptome in comparison to subcutaneous fat (SAT) in coronary artery disease (CAD) and type 2 diabetes (T2DM). METHODS AND RESULTS: SAT and EAT samples were obtained from subjects with T2DM and CAD (n = 5) and those without CAD with or without T2DM (=3) undergoing elective cardiac surgery. RNA-sequencing analysis was performed in both EAT and SAT. Gene enrichment analysis was conducted to identify pathways affected by the differentially expressed genes...
August 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
keyword
keyword
66750
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"