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https://www.readbyqxmd.com/read/28698002/the-flavonol-enriched-cistus-albidus-chloroform-extract-possesses-in-vivo-anti-inflammatory-and-anti-nociceptive-activity
#1
Ouahiba Tahiri, Dina Atmani-Kilani, Susana Sanchez-Fidalgo, Marina Aparicio-Soto, Catalina Alarcón-de-la-Lastra, Enrique Barrajón-Catalán, Vicente Micol, Djebbar Atmani
ETHNOPHARMACOLOGICAL RELEVANCE: Cistus albidus L. (Cistaceae) has been traditionally used to treat various inflammatory diseases, but no systematic studies on the anti-inflammatory and anti-nociceptive actions of C. albidus and its putative mechanism have been reported. We aimed to explore the anti-inflammatory and anti-nociceptive effects of this plant and to characterize its polyphenolic composition by liquid chromatography coupled to mass spectrometry (MS). MATERIALS AND METHODS: A chloroform extract derived from C...
July 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28689797/pudilan-xiaoyan-oral-liquid-alleviates-lps-induced-respiratory-injury-through-decreasing-nitroxidative-stress-and-blocking-tlr4-activation-along-with-nf-%C3%AE-b-phosphorylation-in-mice
#2
Liang Feng, Nan Yang, Chao Li, Gang Tian, Jing Wang, Zi-Bo Dong, Xiao-Bin Jia, Liu-Qing Di
ETHNOPHARMACOLOGICAL RELEVANCE: Pudilan xiaoyan oral liquid (PDL), collected in Chinese Pharmacopoeia, has been used clinically for treating inflammatory diseases such as upper respiratory tract infection diseases. However, its potential anti-inflammation and the mechanism are still unclear. MATERIALS AND METHODS: lipopolysaccharide (LPS) was used to induce respiratory inflammation of mice by intratracheal administration. UPLC/MS was performed for components analysis of PDL...
July 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28680569/ppar%C3%AE-attenuates-hypoxia-induced-hypertrophic-transcriptional-pathways-in-the-heart
#3
Abubakr Chaudhry, Kristal A Carthan, Bum-Yong Kang, John Calvert, Roy L Sutliff, C Michael Hart
Chronic hypoxia-induced pulmonary hypertension (PH) is characterized by increased pressure and resistance in the pulmonary vasculature and hypertrophy of the right ventricle (RV). The transcription factors, nuclear factor activated T-cells (NFAT), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB/p65) contribute to RV hypertrophy (RVH). Because peroxisome proliferator-activated receptor gamma (PPARγ) activation attenuates hypoxia-induced PH and RVH, we hypothesized that PPARγ inhibits activation of RV hypertrophic transcriptional signaling mechanisms...
March 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28676205/small-molecules-to-the-rescue-inhibition-of-cytokine-signaling-in-immune-mediated-diseases
#4
REVIEW
Massimo Gadina, Nathalia Gazaniga, Laura Vian, Yasuko Furumoto
Cytokines are small, secreted proteins associated with the maintenance of immune homeostasis but also implicated with the pathogenesis of several autoimmune and inflammatory diseases. Biologic agents blocking cytokines or their receptors have revolutionized the treatment of such pathologies. Nonetheless, some patients fail to respond to these drugs or do not achieve complete remission. The signal transduction originating from membrane-bound cytokine receptors is an intricate network of events that lead to gene expression and ultimately regulate cellular functionality...
July 1, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28662337/danshen-attenuates-osteoarthritis-related-cartilage-degeneration-through-inhibition-of-nf-%C3%AE%C2%BAb-signaling-pathway-in-vivo-and-in-vitro
#5
Xilin Xu, Hang Lv, Xiaodong Li, Hui Su, Xiaofeng Zhang, Jun Yang
Danshen is a traditional Chinese medicine herb that can alleviate osteoarthritis (Soder et al.) symptoms in animals. However, the underlying mechanisms remain poorly understood and require further investigation. In this study, rabbits with experimental OA were given intra-articular injection of Danshen (0.7 mL/day) for five weeks. In addition to attenuating the cartilage degeneration of OA rabbits, Danshen decreased the expression and activity of matrix metalloproteinase 9 (MMP-9) and MMP-13, whereas increased that of their natural inhibitors, tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) and TIMP-2...
June 29, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28659803/indoxyl-sulfate-affects-glial-function-increasing-oxidative-stress-and-neuroinflammation-in-chronic-kidney-disease-interaction-between-astrocytes-and-microglia
#6
Simona Adesso, Tim Magnus, Salvatore Cuzzocrea, Michela Campolo, Björn Rissiek, Orlando Paciello, Giuseppina Autore, Aldo Pinto, Stefania Marzocco
Indoxyl sulfate (IS) is a protein-bound uremic toxin resulting from the metabolism of dietary tryptophan which accumulates in patients with impaired renal function, such as chronic kidney disease (CKD). IS is a well-known nephrovascular toxin but little is known about its effects on central nervous system (CNS) cells. Considering the growing interest in the field of CNS comorbidities in CKD, we studied the effect of IS on CNS cells. IS (15-60 μM) treatment in C6 astrocyte cells increased reactive oxygen species release and decreased nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activation, and heme oxygenase-1 (HO-1) and NAD(P)H dehydrogenase quinone 1 expression...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28641655/-il-1%C3%AE-treated-bone-marrow-mesenchymal-stem-cells-enhances-osteogenetic-potential-via-nf-%C3%AE%C2%BAb-pathway
#7
Wei Ye, Xiao-Ming Fei, Yu Tang, Xin-Xin Xu, Yan Zhu
Obsjective:To investigate the effects of differentaction time of IL-1β on the osteogenic capacity of bone marrow mensenchymal cells(BMMSC) and the role of nuclear factor-κB (NF-kB) pathway. METHODS: BMMSC isolated from normal donors was treated with IL-1β for 1 or 7 days, respectively. Alkaline phosphatase (ALP) and alizarin red(AR) stainings were used to detect the osteogenic differentiation potential of BMMSC. The mRNA expression of EphB4, IGF-1 and OPG in BMMSC was measured by real-time PCR...
June 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28627188/effect-of-glutamine-on-liver-injuries-induced-by-intestinal-ischemia-reperfusion-in-rats
#8
Renata Hartmann, Francielli Licks, Elizângela Gonçalves Schemitt, Josieli Raskopf Colares, Juliana Da Silva, Rosa Maria Moura, Gilmara Pandolfo Zabot, Henrique Sarubbi Fillmann, Norma Possa Marroni
INTRODUCTION: Intestinal ischemia-reperfusion (I/R) injury may cause cell and tissue damage, reaching also other organs such as the liver. Because of the involvement of free radicals in I/R injury, treatment options with antioxidants have been studied and tested. OBJECTIVE: To evaluate the effect of glutamine (Gln) in the liver of animals with intestinal I/R injury. METHODS: We used 20 male Wistar rats divided into four groups: sham-operated (SO); glutamine + sham-operated (G+SO); intestinal ischemia-reperfusion (I/R); glutamine + intestinal ischemia-reperfusion (G+I/R)...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28611814/mapping-and-preliminary-analysis-of-aborted-microspores-ams-as-the-candidate-gene-underlying-the-male-sterility-ms-5-mutant-in-melon-cucumis-melo-l
#9
Yunyan Sheng, Yudan Wang, Shiqi Jiao, Yazhong Jin, Peng Ji, Feishi Luan
Melon is an important agricultural and economic vegetable crop worldwide. The genetic male sterility mutant (ms-5) has a recessive nuclear gene that controls the male sterility germplasm. Male sterility could reduce the cost of F1 seed production in melon, but heterozygous fertile plants should be removed before pollination. In this study, bulked segregant analysis combined with specific length amplified fragment sequencing was applied to map the single nuclear male sterility recessive gene. A 30-kb candidate region on chromosome 9 located on scaffold 000048 and spanning 2,522,791 to 2,555,104 bp was identified and further confirmed by cleavage amplified polymorphic sequence markers based on parental line resequencing data and classical mapping of 252 F2 individuals...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28609844/an-overview-on-immunoregulatory-and-anti-inflammatory-properties-of-chrysin-and-flavonoids-substances
#10
REVIEW
Majid Zeinali, Seyed Abdolrahim Rezaee, Hossein Hosseinzadeh
Inflammation and the pro-inflammatory cytokines are associated with numerous chronic diseases. Studies suggest that flavonoids, plant polyphenolic compound derivatives from natural origin, have a wide range of putative biological activities. Similar to other flavonoids, chrysin (CH) by its anti-oxidative and anti-inflammatory effects is a potential prophylactic agent in immunopathological and physicochemical injuries. This is an overview on putative immunomodulatory activities of flavonoids and beneficial health effects of these substances particularly, CH in the immune system...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28608141/triterpenoids-principle-of-wedelia-calendulacea-attenuated-diethynitrosamine-induced-hepatocellular-carcinoma-via-down-regulating-oxidative-stress-inflammation-and-pathology-via-nf-kb-pathway
#11
Amita Verma, Deepika Singh, Firoz Anwar, Prakash Chandra Bhatt, Fahad Al-Abbasi, Vikas Kumar
The aerial part of Wedelia calendulacea have been used in Ayurveda, Unani, Tibetan, Siddha and other folk medicine systems to protect the liver and renal tissue. Liver is considered as primary metabolizing site of body, which is prone to damage by endogenous and exogenous toxicants. A reason for liver toxicity, and major causes of the hepatocellular carcinoma (HCC). 19-α-Hydroxyurs-12(13)-ene-28 oic acid-3-O-β-D-glucopyranoside (HEG), a triterpenoids found in the higher plants, has been known to possess protective effect against various toxicants...
June 12, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28602680/two-novel-p38-mapks-identified-from-epinephelus-coioides-and-their-expression-pattern-in-response-to-cryptocaryon-irritans-infection
#12
Hong-Yan Sun, Mian-Zhi Huang, Yan-Wei Li, Jia-Hao Huang, Ze-Quan Mo, Rui-Ai Chen, Xue-Ming Dan
P38 mitogen-activated protein kinases (MAPKs) are one of the most important central regulatory proteins response to extra environmental stresses. In this study, two novel p38 MAPKs, Ec-P38γ and Ec-P38δ, were identified from Epinephelus coioides, an economically important cultured fish in China and Southeast Asian counties. Both of Ec-p38γ and Ec-p38δ sequences contain a serine/threonine protein kinase (S_TKc) domain and a highly conserved Thr-Gly-Tyr (TGY) motif. Analysis of phylogenetic relationships illustrated that p38 amino acid sequences were conserved between different species indicating that the functions may be similar...
August 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28591668/the-selective-estrogen-receptor-modulators-serms-raloxifene-and-tamoxifen-improve-anp-levels-and-decrease-nuclear-translocation-of-nf-kb-in-estrogen-deficient-rats
#13
Aline Z Lamas, Andrews M Nascimento, Ana Raquel S Medeiros, Izabela F Caliman, Polyana L M Dalpiaz, Luciana B Firmes, Glauciene J Sousa, Phablo Wendell C Oliveira, Tadeu U Andrade, Adelina M Reis, Sônia A Gouvea, Nazaré S Bissoli
BACKGROUND: The selective estrogen receptor modulators (SERMs) raloxifene and tamoxifen are used for the treatment of osteoporosis and cancer, respectively, in women. The impairment of both the Atrial Natriuretic Peptide (ANP) cell signaling system and the translocation of nuclear factor-kappa B (NF-kB) to the cell nucleus are associated with detrimental cardiovascular effects and inflammation. The effects of SERMs on these parameters in the cardiac tissue of estrogen-deficient rats has not been reported...
March 16, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28580511/effect-of-recent-spinal-cord-injury-on-the-opg-rankl-system-and-its-relationship-with-bone-loss-and-the-response-to-denosumab-therapy
#14
L Gifre, S Ruiz-Gaspà, J L Carrasco, E Portell, J Vidal, A Muxi, A Monegal, N Guañabens, P Peris
There is marked bone loss after spinal cord injury (SCI); however, its pathogenesis and clinical management remain unclear. The increased circulating levels of receptor activator of nuclear factor kB ligand (RANKL) associated with bone loss shortly after SCI and the prevention of bone loss with denosumab treatment suggest a contributory role of RANKL in SCI-induced osteoporosis. INTRODUCTION: Bone turnover and bone loss are markedly increased shortly after SCI. However, the pathogenesis and clinical management of this process remain unclear, especially the role of the osteoprotegerin (OPG)/RANKL system in this disorder...
June 4, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28578349/ptpro-promotes-oxidized-low-density-lipoprotein-induced-oxidative-stress-and-cell-apoptosis-through-toll-like-receptor-4-nuclear-factor-%C3%AE%C2%BAb-pathway
#15
Caihong Liang, Xiaochen Wang, Jianping Hu, Xiaoqing Lian, Tiantian Zhu, Hui Zhang, Ning Gu, Jun Li
BACKGROUND/AIMS: Critical roles of phosphatase receptor type O (PTPRO) and toll-like receptor 4 (TLR4) have been implicated in inflammation. However, little is known about their functional effects on atherosclerosis (AS). We aim to study their potential function in AS. METHODS: An oxidized low-density lipoprotein (ox-LDL) induced AS model constructed with PTPRO over-expressing RAW264.7 cells and PTPRO knockout macrophages. Cell apoptosis was assayed by flow cytometry and fatty accumulation was evaluated by oil red staining...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28573503/endoplasmic-reticulum-stress-nrf2-signalling-and-cardiovascular-diseases-in-a-nutshell
#16
REVIEW
Chiara Mozzini, Luciano Cominacini, Ulisse Garbin, Anna Maria Fratta Pasini
PURPOSE OF REVIEW: This short review is intended primarily to summarize the understanding of the interrelated roles of endoplasmic reticulum (ER) stress, oxidative stress and inflammation in cardiovascular diseases. RECENT FINDINGS: Insults interfering with ER function lead to the accumulation of unfolded and misfolded proteins in the ER. An excess of proteins folding in the ER is known as ER stress. This condition initiates the unfolded protein response (UPR). When the UPR fails to control the level of unfolded and misfolded proteins, ER-initiated apoptotic signalling is induced...
August 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28572767/glia-maturation-factor-and-mitochondrial-uncoupling-proteins-2-and-4-expression-in-the-temporal-cortex-of-alzheimer-s-disease-brain
#17
Ramasamy Thangavel, Duraisamy Kempuraj, Smita Zaheer, Sudhanshu Raikwar, Mohammad E Ahmed, Govindhasamy Pushpavathi Selvakumar, Shankar S Iyer, Asgar Zaheer
Alzheimer's disease (AD) is characterized by the presence of neuropathological lesions containing amyloid plaques (APs) and neurofibrillary tangles (NFTs). AD is associated with mitochondrial dysfunctions, neuroinflammation and neurodegeneration in the brain. We have previously demonstrated enhanced expression of the proinflammatory protein glia maturation factor (GMF) in glial cells near APs and NFTs in the AD brains. Parahippocampal gyrus consisting of entorhinal and perirhinal subdivisions of temporal cortex is the first brain region affected during AD pathogenesis...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28539257/propranolol-treatment-lowers-blood-pressure-reduces-vascular-inflammatory-markers-and-improves-endothelial-function-in-obese-mice
#18
Nathalia da Silva Franco, Camila Lubaczeuski, Daniele M Guizoni, Jamaira A Victorio, Junia C Santos-Silva, Patricia C Brum, Everardo M Carneiro, Ana P Davel
Obesity-associated hypertension is accompanied by a number of cardiovascular risk factors including vascular insulin resistance (IR) and higher sympathetic nervous activity. Therefore, autonomic blockade was demonstrated to reverse hypertension, endothelial dysfunction and IR in obese individuals. We hypothesized that β-AR blockade with propranolol would restore endothelial function and vascular insulin signaling in obesity, associated with an anti-inflammatory effect. Body weight, systolic blood pressure (SBP), plasma biochemical parameters and aortic endothelial function were analyzed in mice fed standard diet (control group) or a high fat diet (HFD) that were treated with vehicle (water) or propranolol (10mg/kg/day) for 8weeks...
May 21, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28537244/-transcription-factors-nf-kb-hif-1-hif-2-growth-factor-vegf-vegfr2-and-carboanhydrase-ix-mrna-and-protein-level-in-the-development-of-kidney-cancer-metastasis
#19
L V Spirina, Y A Usynin, Z A Yurmazov, E M Slonimskaya, E S Kolegova, I V Kondakova
Here, we have investigated the participation of nuclear factors NF-kB, HIF-1 and HIF-2, VEGF, VEGFR2, and carboanhydrase IX in clear-cell renal cancer. We have determined the expression and protein level of transcription factors, VEGF, VEGFR2, and carboanhydrase IX in tumor and normal tissues of 30 patients with kidney cancer. The Real-Time PCR and ELISA were used in the study. The low levels of HIF-1 mRNA expression associated with high levels of HIF-1 protein were also associated with metastasis. The expression levels of VEGF, VEGFR2, and their protein levels are increased in primary tumors of patients with disseminated kidney cancer compared to nonmetastatic cancer...
March 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28536720/prostaglandin-endoperoxide-synthase-2-deletion-affects-the-natural-trafficking-of-annexin-a2-in-monocytes-and-favours-venous-thrombosis-in-mice
#20
Patrizia Amadio, Eva Tarantino, Leonardo Sandrini, Elena Tremoli, Silvia S Barbieri
Deep-vein thrombosis (DVT) is a common condition that often leads to pulmonary thromboembolism (VTE) and death. The role of prostaglandin-endoperoxide synthase (PTGS)2 in arterial thrombosis has been well established, whereas its impact in venous thrombosis remains unclear. Here, we showed that PTGS2 deletion predisposes to venous thrombosis as suggested by greater clot firmness and clot elasticity, by higher plasma levels of functional fibrinogen, factor VIII and PAI-1 activity, and proved by bigger thrombi detected after inferior vena cava ligation (IVCL) compared to WT mice...
May 24, 2017: Thrombosis and Haemostasis
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