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https://www.readbyqxmd.com/read/28523415/pictorial-review-of-vascular-involvement-and-complex-vascular-reconstructions-in-borderline-to-minimally-advanced-pancreatic-malignancies
#1
REVIEW
Donald L Ly, Seng Thipphavong, Boraiah Sreeharsha
PURPOSE: To review borderline resectability criteria for pancreatic malignancies, show examples of few surgically treated minimally advanced pancreatic malignancies, discuss various complex vascular reconstructions, and highlight the imaging appearances. BACKGROUND: Often aggressive surgical approaches are used to treat borderline to minimally advanced pancreatic malignancies in specialist centers. As abdominal radiologists it is essential to have up-to-date knowledge to distinguish such tumors with accuracy and also be well versed with the various vascular reconstructions used in such surgeries...
May 18, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28502014/inventions-and-patents-a-practical-tutorial
#2
Hina Mehta, Lille Tidwell, Lance A Liotta
Patents are designed to protect and encourage creativity and innovation. Patenting a biomedical discovery can be a requirement before a pharmaceutical company or biotech entity will invest in the lengthy and capital-intensive drug development and clinical trials necessary to achieve patient benefit. Although scientists and clinicians are well versed in research publication requirements, patent descriptions and claims are formatted in a manner quite different from a research paper. Patents require (a) a series of logical statements clearly delineating the boundaries of the novel aspects of the invention and (b) sufficient disclosure of the invention so that it can be reproduced by others...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28499137/a-comparison-of-the-ground-reaction-force-frequency-content-during-rearfoot-and-non-rearfoot-running-patterns
#3
Allison H Gruber, W Brent Edwards, Joseph Hamill, Timothy R Derrick, Katherine A Boyer
Running with a non-rearfoot pattern has been claimed to reduce injury risk because the impact peak in the vertical ground reaction force (GRF) is visually absent in the time-domain compared with a rearfoot pattern. However, running results in a rapid deceleration of the lower extremity segments immediately following initial contact with the ground, regardless of footfall pattern. Therefore, the frequency content of the GRF is expected to contain evidence of this collision. The purpose of the present study was to characterize the waveform components of the GRF generated during the impact phase by habitual rearfoot and habitual non-rearfoot pattern groups using the continuous wavelet transform...
April 28, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28465133/jcl-roundtable-future-of-the-lipid-laboratory-choosing-valuable-measures-among-the-lipoproteins-part-1
#4
REVIEW
William Virgil Brown, Yehuda Handelsman, Seth S Martin, Pamela B Morris
The measurement of cholesterol and triglycerides as indicators of metabolic disorders and most particularly of vascular disease risk has been of growing importance to physicians and epidemiologists over the past century. This was refocused on the lipoproteins, the specific packages in blood that carry these lipids, by John Gofman, MD, PhD, and Don Fredrickson, MD, more than 50 years ago. We continue to learn about the metabolism of these large molecular structures and their relationship to arteriosclerosis as new genetic and interventional studies are published...
April 21, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28464696/an-epidemiological-study-of-population-health-reveals-social-smoking-as-a-major-cardiovascular-risk-factor
#5
Kate Sustersic Gawlik, Bernadette Mazurek Melnyk, Alai Tan
PURPOSE: To present nationally representative data on the prevalence of "social" smoking and its relationship to cardiovascular health. DESIGN: A population-based, cross-sectional survey on cardiovascular health and its risk factors across the United States. SETTING: Million Hearts(®) cardiovascular screenings that took place in community settings. PARTICIPANTS: De-identified data were collected on a convenient sample of 39, 555 participants...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28457858/human-diseases-associated-with-connexin-mutations
#6
REVIEW
Miduturu Srinivas, Vytas K Verselis, Thomas W White
Gap junctions and hemichannels comprised of connexins impact many cellular processes. Significant advances in our understanding of the functional role of these channels have been made by the identification of a host of genetic diseases caused by connexin mutations. Prominent features of connexin disorders are the inability of other connexins expressed in the same cell type to compensate for the mutated one, and the ability of connexin mutants to dominantly influence the activity of other wild-type connexins...
April 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28446825/vaidyavallabha-an-authoritative-work-on-ayurveda-therapeutics
#7
REVIEW
Arhanth Kumar Jain, Shreevathsa Manjunath
The text "Vaidyavallabha" is an authoritative work on Ayurvedic therapeutics written by Hastiruci, a Jain scholar. It belongs to the time period of 1673-1726 CE. Different physical and mental ailments with their treatments are addressed in the 274 verses spanned over eight chapters in this work. In this text many unique, special and simple medicinal preparations for different diseases are given. Many drugs which were easily available in the local area are given much more importance in the treatment. Added to this, method and uniqueness of naming the diseases in the text stand differently when compared to other texts...
October 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/28446200/human-germ-stem-cell-specific-gene-tex19-influences-cancer-cell-proliferation-and-cancer-prognosis
#8
Vicente Planells-Palop, Ali Hazazi, Julia Feichtinger, Jana Jezkova, Gerhard Thallinger, Naif O Alsiwiehri, Mikhlid Almutairi, Lee Parry, Jane A Wakeman, Ramsay J McFarlane
BACKGROUND: Cancer/testis (CT) genes have expression normally restricted to the testis, but become activated during oncogenesis, so they have excellent potential as cancer-specific biomarkers. Evidence is starting to emerge to indicate that they also provide function(s) in the oncogenic programme. Human TEX19 is a recently identified CT gene, but a functional role for TEX19 in cancer has not yet been defined. METHODS: siRNA was used to deplete TEX19 levels in various cancer cell lines...
April 26, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28441597/differences-in-nitrate-and-phosphorus-export-between-wooded-and-grassed-riparian-zones-from-farmland-to-receiving-waterways-under-varying-rainfall-conditions
#9
Amanda D Neilen, Chengrong R Chen, Brett M Parker, Stephen J Faggotter, Michele A Burford
Agricultural activities in catchments can cause excessive nutrient loads in waterways. Catchment nitrogen (N) and phosphorus (P) flows may be intercepted and assimilated by riparian vegetation. While prior studies suggest that woody vegetation is preferable for reducing P loads, the question remains: is woody vegetation or grass cover more effective at reducing catchment N and P exports to waterways. To address this we investigated the relative importance of vegetation type, hydrologic and soil microbial processes on N and P losses from soil to a stream...
April 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28434782/dimeric-isoxazolyl-1-4-dihydropyridines-have-enhanced-binding-at-the-multi-drug-resistance-transporter
#10
Scott A Steiger, Chun Li, Donald S Backos, Philip Reigan, N R Natale
A series of dimeric isoxazolyl-1,4-dihydropyridines (IDHPs) were prepared by click chemistry and examined for their ability to bind the multi-drug resistance transporter (MDR-1), a member of the ATP-binding cassette superfamily (ABC). Eight compounds in the present study exhibited single digit micromolar binding to this efflux transporter. One monomeric IDHP m-Br-1c, possessed submicromolar binding of 510nM at MDR-1. Three of the dimeric IDHPs possessed <1.5µM activity, and 4b and 4c were observed to have superior binding selectivity compared to their corresponding monomers verses the voltage gated calcium channel (VGCC)...
April 8, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28423542/dna-methylation-intratumor-heterogeneity-in-localized-lung-adenocarcinomas
#11
Kelly Quek, Jun Li, Marcos Estecio, Jiexin Zhang, Junya Fujimoto, Emily Roarty, Latasha Little, Chi-Wan Chow, Xingzhi Song, Carmen Behrens, Taiping Chen, William N William, Stephen Swisher, John Heymach, Ignacio Wistuba, Jianhua Zhang, Andrew Futreal, Jianjun Zhang
Cancers are composed of cells with distinct molecular and phenotypic features within a given tumor, a phenomenon termed intratumor heterogeneity (ITH). Previously, we have demonstrated genomic ITH in localized lung adenocarcinomas; however, the nature of methylation ITH in lung cancers has not been well investigated. In this study, we generated methylation profiles of 48 spatially separated tumor regions from 11 localized lung adenocarcinomas and their matched normal lung tissues using Illumina Infinium Human Methylation 450K BeadChip array...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417851/nuclear-medicine-techniques-in-pediatric-bone-imaging
#12
REVIEW
Laura A Drubach
An important mandate when imaging pediatric patients is the reduction of radiation exposure to the lowest possible level consistent with good quality diagnostic imaging, so individual selection of radiopharmaceutical dosage and imaging technique is essential. Although the logistics of image acquisition and the approach to interpretation mirror the more common use in adults, the challenges of imaging young children typically require greater attention to patient preparation, positioning, and supervision during imaging, with the use of parental or family engagement in the procedure, gentle restraint, and occasionally the need for sedation...
May 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28410653/ensuring-patient-safety-during-the-transition-to-esrd
#13
REVIEW
Lee-Ann Wagner, Jeffrey C Fink
Patients with chronic kidney disease (CKD) are at risk for complications both inherent to the disease and as a consequence of its treatment. The dangers that CKD patients face change across the spectrum of the disease. Providers who are well-versed in these safety threats are best poised to safeguard patients as their CKD progresses.
March 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28401673/morphology-of-modern-arrowhead-tips-on-human-skin-analog
#14
LokMan Sung, Kilak Kesha, Jeffrey Hudson, Kelly Root, Leigh Hlavaty
Archery has experienced a recent resurgence in participation and has seen increases in archery range attendance and in children and young adults seeking archery lessons. Popular literature and movies prominently feature protagonists well versed in this form of weaponry. Periodic homicide cases in the United States involving bows are reported, and despite this and the current interest in the field, there are no manuscripts published on a large series of arrow wounds. This experiment utilizes a broad selection of modern arrowheads to create wounds for comparison...
April 12, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28384898/primary-management-and-outcome-open-laryngotracheal-trauma
#15
Santosh Uttarkar Pandurangarao, Prashanth Basavaraj, Supriya Baswaraj Yempalle, Lavanya Karnam
Acute external injury to the larynx is both life threatening and a potential long term management challenge. As Otorhinolaryngologist we must be prepared and well versed to manage these patients. In our study seven patients of open laryngeal traumas were managed by primary closure. In five patients nature of injury was known in other two patients exact nature of injury was not known. After primary closure five patients with known injury survived and two patients with unknown injury died. As per our experience, we recommend primary closure, if the exact nature of injury is known as the outcome is definitely favourable...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28381239/prevalence-of-group-a-streptococcus-pharyngeal-carriage-and-clinical-manifestations-in-school-children-aged-5-15%C3%A2-yrs-in-wakiso-district-uganda
#16
Irene Nayiga, Emmy Okello, Peter Lwabi, Grace Ndeezi
BACKGROUND: Beta-hemolytic streptococci carrier rates in children living in low-income countries are high ranging from 10 to 50%. Although most of these children are asymptomatic, they are a reservoir and pose a risk of transmission. The aim of this study was to determine the prevalence of group a streptococcus pharyngeal carriage and clinical manifestations in school going children in Wakiso district, Uganda. METHODS: A cross sectional study targeting children age 5-15 years in primary schools in one sub-county of Wakiso district was carried out...
April 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28372949/sleep-disordered-breathing-in-neuromuscular-disease-diagnostic-and-therapeutic-challenges
#17
REVIEW
Loutfi S Aboussouan, Eduardo Mireles-Cabodevila
Normal sleep related rapid eye movement sleep atonia, reduced lung volumes, reduced chemosensitivity, and impaired airway dilator activity, become significant vulnerabilities in the setting of neuromuscular disease. In that context, the compounding effects of respiratory muscle weakness and disease-specific features that promote upper airway collapse or cause dilated cardiomyopathy, contribute to various sleep-disordered breathing events. The reduction in lung volumes with neuromuscular disease is further compromised by sleep and the supine position, exaggerating the tendency for upper airway collapse and desaturation with sleep-disordered breathing events...
March 31, 2017: Chest
https://www.readbyqxmd.com/read/28362961/audiovestibular-handicap-and-quality-of-life-in-patients-with-vestibular-schwannoma-and-excellent-hearing
#18
Oystein Vesterli Tveiten, Matthew L Carlson, Michael J Link, Morten Lund-Johansen
BACKGROUND: Studies examining patient-reported outcomes in subjects with vestibular schwannoma (VS) and "excellent" hearing are lacking. OBJECTIVE: To assess patient-reported audiovestibular handicap and overall quality of life (QoL) in VS patients with class A hearing in both ears. METHODS: Among 539 VS patients treated during 1998 to 2008, we identified 296 patients with either bilateral class A (AA) hearing or 1 good ear and 1 deaf ear (AD) according to the American Academy of Otolaryngology-Head and Neck Surgery classification...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28361233/rna-seq-analysis-for-transcriptome-profiling-in-response-to-classical-swine-fever-vaccination-in-indigenous-and-crossbred-pigs
#19
Shalu Kumari Pathak, Amit Kumar, G Bhuwana, Vaishali Sah, Vikramadiya Upmanyu, A K Tiwari, A P Sahoo, A R Sahoo, Sajjad A Wani, Manjit Panigrahi, N R Sahoo, Ravi Kumar
In present investigation, differential expression of transcriptome after classical swine fever (CSF) vaccination has been explored at the cellular level in crossbred and indigenous (desi) piglets. RNA Sequencing by Expectation-Maximization (RSEM) package was used to quantify gene expression from RNA Sequencing data, and differentially expressed genes (DEGs) were identified using EBSeq, DESeq2, and edgeR softwares. After analysis, 5222, 6037, and 6210 common DEGs were identified in indigenous post-vaccinated verses pre-vaccinated, crossbred post-vaccinated verses pre-vaccinated, and post-vaccinated crossbred verses indigenous pigs, respectively...
March 30, 2017: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/28355745/-cinnamaldehyde-attenuates-pressure-overload-induced-cardiac-fibrosis-via-inhibition-of-endothelial-mesenchymal-transition
#20
Y Xiao, Q Q Wu, X H Jiang, Q Z Tang
Objective: The aim of this study is to investigate the underlying mechanism of cinnamaldehyde attenuating pressure overload-induced cardiac fibrosis. Methods: The mice were randomly divided into control group, model group and treatment group by random number table and each group had 8 mice.Cardiac hypertrophy was induced by aortic banding. Heart vascular density was detected by immunohistochemical staining of CD31.The expression level of stromal cells marker α-smooth muscle actin (α-SMA) was detected by immunofluorescence staining in different groups...
March 21, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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