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https://www.readbyqxmd.com/read/29770253/simultaneous-cerebrospinal-fluid-and-hematologic-metastases-in-a-high-grade-ependymoma
#1
Daniel Diaz-Aguilar, Sergei Terterov, Alexander M Tucker, Shaina Sedighim, Rudi Scharnweber, Stephanie Wang, Catherine Merna, Shayan Rahman
Background: Ependymomas are relatively uncommon tumors that constitute about 7% of all primary intracranial neoplasms. Among these, high-grade ependymomas are locally aggressive and recur most commonly at the primary site following resection. Ependymomas are also known to be the one glial neoplasm that tends to frequently metastasize inside and outside the central nervous system (CNS) that complicates workup and management. Metastasis due to surgical manipulation is common and neurosurgeons should be well-versed in the most effective methods to remove these tumors in order to avoid such metastases...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29767907/the-teacher-s-body-elements-that-influence-the-teaching-learning-process-of-university-nursing-students
#2
Paulo Sérgio da Silva, Nébia Maria Almeida de Figueiredo
OBJECTIVES: To identify the body elements of the teacher that influence the teaching-learning process and to analyze their effects on university nursing students. METHODS: Qualitative research with descriptive approach implemented through a dramatic play dynamics. In the second half of 2015, sixteen students from a private university center located in Rio de Janeiro (Brazil) participated in the study. The data processing was carried out by using Bardin's theoretical and analytical framework...
October 2017: Investigación y Educación en Enfermería
https://www.readbyqxmd.com/read/29766734/-more-safe-anticoagulant-treatment-use-of-idarucizumab-praxbind%C3%A2-case-reports-from-re-verse-ad-study-and-clinical-practice
#3
David Tuček, Tomáš Veleta, Martin Havrda
RE-VERSE AD, a prospective multicentric cohort study, examined the effect of idarucizumab on 2 cohorts of patients anticoagulated with dabigatran - in cohort A in patients with uncontrollable or life threatening bleeding, in cohort B in patients who undergo acute surgery. Within the study patients were intravenously administered 5 g antidote divided into 2 doses per 2.5 g within 15 min to eliminate the anticoagulation effect of dabigatran. A series of case studies is presented to describe the use of idarucizumab within the RE-VERSE AD study and in clinical practice in the period of 2015-2016 at the University Hospital Hradec Králové...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29765593/appendico-ilial-knotting-a-rare-cause-of-small-bowel-obstruction
#4
Anteneh Tadesse Kifle, Samuel Tesfaye
Small bowel obstruction (SBO) is one of the most common acute surgical conditions that needs immediate innervation to prevent the morbidity and mortality associated with it. The common causes of SBO are different in developed and developing nations. Well-versed knowledge of the rare causes of SBO including its option of management is necessary. In this article, we present a case of an acute SBO secondary to Appendico-ileal knotting. The diagnostic difficulty and the options of management are discussed.
May 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29744021/poet-s-pen-verses-upon-the-burning-of-our-house
#5
(no author information available yet)
No abstract text is available yet for this article.
October 2017: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/29731261/wasp-write-a-scientific-paper-ethics-approval-for-a-research-study-2
#6
Pierre Mallia
Research Ethics Committees are composed of a minimum of five members which include a lay person, a member from a different institution and at least another three members which should be versed in ethics. Legal and expert advisors can be sought by the committee. The REC will require a detailed protocol from the researcher including the curriculum of the principal investigator and all other researchers under him/her. The protocol should include all details of the research to be undertaken including a detailed description, the reasons for the research, literature pertaining to the research, a clear description of the target population, the actual consent form including what information is to be given to the participants, a declaration where necessary that things prohibited by the law (such as use of embryonic stem cells if this is the case in the country [2] will not be researchers, and a declaration that the relevant directives and rules and procedures which the REC falls under will be followed...
May 3, 2018: Early Human Development
https://www.readbyqxmd.com/read/29728259/shortcut-assessment-can-residents-operative-performance-be-determined-in-the-first-five-minutes-of-an-operative-task
#7
Hossein Mohamadipanah, Jay Nathwani, Katherine Peterson, Katherine Forsyth, Lakita Maulson, Shannon DiMarco, Carla Pugh
BACKGROUND: The aim was to validate the potential use of a single, early procedure, operative task as a predictive metric for overall performance. The authors hypothesized that a shortcut psychomotor assessment would be as informative as a total procedural psychomotor assessment when evaluating laparoscopic ventral hernia repair performance on a simulator. METHODS: Using electromagnetic sensors, hand motion data were collected from 38 surgery residents during a simulated laparoscopic ventral hernia repair procedure...
May 1, 2018: Surgery
https://www.readbyqxmd.com/read/29726067/readability-of-endoscopy-information-leaflets-implications-for-informed-consent
#8
Matthew C Mason, James M L Williamson
INTRODUCTION: Valid consent for gastrointestinal endoscopy is required for ethical and legal reasons. Patients are frequently met by an endoscopist for the first time on the day of their procedure. For valid consent to be possible, the patient needs to have received and understood generic information regarding endoscopy in advance. Patient information leaflets (PILs) need to be easily understood by the majority of the population. METHOD: PILs from 14 secondary care institutions and a sample PIL from the British Society of Gastroenterology were analysed using an online readability tool...
May 3, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29701961/post-translational-tyrosine-geranylation-in-cyanobactin-biosynthesis
#9
Maho Morita, Yue Hao, Jouni K Jokela, Debosmita Sardar, Zhenjian Lin, Kaarina Sivonen, Satish K Nair, Eric W Schmidt
Prenylation is a widespread modification that improves the biological activities of secondary metabolites. This reaction also represents a key modification step in biosyntheses of cyanobactins, a family of ribosomally synthesized and post-translationally modified peptides (RiPPs) produced by cyanobacteria. In cyanobactins, amino acids are commonly isoprenylated by ABBA prenyltransferases that use C5 donors. Notably, mass spectral analysis of piricyclamides from a fresh-water cyanobacterium suggested that they may instead have a C10 geranyl group...
May 1, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29701258/evaluation-of-smartphone-based-testing-to-generate-exploratory-outcome-measures-in-a-phase-1-parkinson-s-disease-clinical-trial
#10
Florian Lipsmeier, Kirsten I Taylor, Timothy Kilchenmann, Detlef Wolf, Alf Scotland, Jens Schjodt-Eriksen, Wei-Yi Cheng, Ignacio Fernandez-Garcia, Juliane Siebourg-Polster, Liping Jin, Jay Soto, Lynne Verselis, Frank Boess, Martin Koller, Michael Grundman, Andreas U Monsch, Ronald B Postuma, Anirvan Ghosh, Thomas Kremer, Christian Czech, Christian Gossens, Michael Lindemann
BACKGROUND: Ubiquitous digital technologies such as smartphone sensors promise to fundamentally change biomedical research and treatment monitoring in neurological diseases such as PD, creating a new domain of digital biomarkers. OBJECTIVES: The present study assessed the feasibility, reliability, and validity of smartphone-based digital biomarkers of PD in a clinical trial setting. METHODS: During a 6-month, phase 1b clinical trial with 44 Parkinson participants, and an independent, 45-day study in 35 age-matched healthy controls, participants completed six daily motor active tests (sustained phonation, rest tremor, postural tremor, finger-tapping, balance, and gait), then carried the smartphone during the day (passive monitoring), enabling assessment of, for example, time spent walking and sit-to-stand transitions by gyroscopic and accelerometer data...
April 27, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29694526/-the-poetry-of-augusto-dos-anjos-and-fin-de-si%C3%A3-cle-neuropsychiatry
#11
Leonardo Cruz de Souza, Ana Carolina Sarquis Salgado, Maurício Viotti Daker, Francisco Cardoso, Antônio Lúcio Teixeira
Augusto dos Anjos, from Paraíba, Brazil, occupies a singular place in Brazilian literature, defying alignment with any one literary style. His poetry is marked by anguished verse, by existential dimensions and a vocabulary replete with scientific terms. His work is of great interest to neuropsychiatry, not just for the abundance of related terms, but also because it reflects conceptions from neuroscience at the turn of the twentieth century. This study focuses on his literary output from a dual perspective: by identifying how his poetry reflects the organicist tendency in psychiatry at the time, as generally personified in the figure of Emil Kraepelin, and by exploring the ideological content of the work, like the Darwinist perspective and the tension between dualism and materialistic monism...
March 2018: História, Ciências, Saúde—Manguinhos
https://www.readbyqxmd.com/read/29690963/carbamazepine-verses-valproic-acid-as-monotherapy-in-epileptic-patients
#12
Shakirullah Shakir, Niaz Ali, Haleema Nazish
OBJECTIVE: To evaluate the effectiveness of carbamazepine and valproic acid as monotherapy in epileptic patients of Pakhtun population. STUDY DESIGN: An experimental study. PLACE AND DURATION OF STUDY: The outpatient Neurology Department, Lady Reading Hospital, Peshawar, from August 2014 to April 2016. METHODOLOGY: Epileptic patients placed on carbamazepine and volproic acid were inducted. Carbamazepine and valproic acid plasma levels were determined using reverse phase high performance liquid chromatography...
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29683935/re-clinical-and-qualitative-isokinetic-comparison-of-abdominal-morbidity-and-dynamics-following-diep-verses-muscle-sparing-free-tram-flap-breast-reconstruction
#13
Jonas A Nelson, Joseph J Disa
No abstract text is available yet for this article.
March 31, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29679558/self-restrained-regulation-of-stem-cell-niche-activity-by-niche-components-in-the-drosophila-testis
#14
Ran Xu, Jing Li, Hang Zhao, Ruiyan Kong, Min Wei, Lin Shi, Guang Bai, Zhouhua Li
Most, if not all, stem cells reside in a defined microenvironment, called the niche. Short-ranged niche signal must be tightly controlled to be active only inside the niche to maintain the proper balance of stem cell self-renewal verse differentiation. However, how niche components restrict localized niche signal activation remains largely unknown. Here, we find that Thickveins (Tkv, a type I receptor of the Dpp signaling pathway) in cyst stem cells (CySCs) of the testis niche prevents Dpp signaling activation outside of the niche...
April 18, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29677028/treatment-of-tobacco-dependence-current-state-of-the-art
#15
Hasmeena Kathuria, Frank T Leone, Enid R Neptune
PURPOSE OF REVIEW: The Centers for Medicare and Medicaid Services' requirement to integrate tobacco treatment with lung cancer screening (LCS) has served as a catalyst for motivating pulmonary medicine clinicians to improve upon their ability to effectively treat tobacco dependence. To do so, clinicians need to be well versed in the behavioral and pharmacologic tools that promote smoking cessation. RECENT FINDINGS: The current review outlines current strategies for treating tobacco dependence, focusing on the important interplay between counseling and pharmacotherapy...
April 18, 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29672434/assessment-of-cartilage-growth-after-biopsy-of-osteochondral-loose-bodies-in-adolescent-knees-for-use-in-autologous-chondrocyte-implantation
#16
Sean Robinson, Jonathan Kramer, Trevor Shelton, Jarrad Merriman, Brian Haus
BACKGROUND: The goal of this study is to determine whether harvested cartilage from an osteochondral loose body maintains the same viability for implantation as cartilage harvested from the traditional locations within the adolescent knee for autologous chondrocyte implantation (ACI). METHODS: A retrospective study was performed on all ACI procedures performed from 2014 to 2017 at a single institution. Biopsies were derived from 2 groups: osteochondral loose body verses the intercondylar notch...
April 18, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29643877/comparison-between-primary-closure-with-limberg-flap-versus-open-procedure-in-treatment-of-pilonidal-sinus-in-terms-of-frequency-of-post-operative-wound-infection
#17
Muhammad Sohail Jabbar, Mahwish Mahboob Bhutta, Nayyab Puri
Objective: Pilonidal sinus is a disorder of the sacrococcygeal region affecting younger individuals with a higher hair and weight distribution. Treatment involves the use of various surgical modalities, most of which are associated with a high rate of complications. Open procedure (OP) and Limberg Flap (LF) are two commonly performed surgical procedures for the correction of pilonidal sinus disease in our setup. The objective of our study was to compare the treatment of pilonidal sinus disease by primary closure with Limberg Flap verses Open procedure in terms of frequency of postoperative wound infection...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29630040/gel-seq-a-method-for-simultaneous-sequencing-library-preparation-of-dna-and-rna-using-hydrogel-matrices
#18
Gordon D Hoople, Andrew Richards, Yan Wu, Albert P Pisano, Kun Zhang
The ability to amplify and sequence either DNA or RNA from small starting samples has only been achieved in the last five years. Unfortunately, the standard protocols for generating genomic or transcriptomic libraries are incompatible and researchers must choose whether to sequence DNA or RNA for a particular sample. Gel-seq solves this problem by enabling researchers to simultaneously prepare libraries for both DNA and RNA starting with 100 - 1000 cells using a simple hydrogel device. This paper presents a detailed approach for the fabrication of the device as well as the biological protocol to generate paired libraries...
March 26, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29602527/abdominal-cutaneous-nerve-entrapment-syndrome-the-cause-of-localized-abdominal-pain-in-a-young-pregnant-woman
#19
Sody A Naimer
BACKGROUND: Despite the broad differential diagnosis in any patient referring with symptoms involving the chest or abdomen, a small number of conditions overshadow the rest by their probability. Chest and abdominal wall pain continues to constitute a common and expensive overlooked source of pain of unknown cause. In particular, cutaneous nerve entrapment syndrome is commonly encountered but not easily diagnosed unless its specific symptoms are sought and the precise physical examination undertaken...
March 27, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29581040/female-false-positive-exercise-stress-ecg-testing-fact-verses-fiction
#20
Benjamin T Fitzgerald, William M Scalia, Gregory M Scalia
BACKGROUND: Exercise stress testing is a well validated cardiovascular investigation. Accuracy for treadmill stress electrocardiograph (ECG) testing has been documented at 60%. False positive stress ECGs (exercise ECG changes with non-obstructive disease on anatomical testing) are common, especially in women, limiting the effectiveness of the test. This study investigates the incidence and predictors of false positive stress ECG findings, referenced against stress echocardiography (SE) as a standard...
March 7, 2018: Heart, Lung & Circulation
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