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testicular staging with x ray

Sebastian E E Schagen, Peggy T Cohen-Kettenis, Henriette A Delemarre-van de Waal, Sabine E Hannema
INTRODUCTION: Puberty suppression using gonadotropin-releasing hormone agonists (GnRHas) is recommended by current guidelines as the treatment of choice for gender dysphoric adolescents. Although GnRHas have long been used to treat precocious puberty, there are few data on the efficacy and safety in gender dysphoric adolescents. Therefore, the Endocrine Society guideline recommends frequent monitoring of gonadotropins, sex steroids, and renal and liver function. AIM: To evaluate the efficacy and safety of GnRHa treatment to suppress puberty in gender dysphoric adolescents...
July 2016: Journal of Sexual Medicine
Yi Wei, Shengde Wu, Tao Lin, Dawei He, Xuliang Li, Junhong Liu, Xing Liu, Yi Hua, Peng Lu, Guanghui Wei
BACKGROUND: To describe 19 years of clinical experience managing pediatric patients with testicular yolk sac tumors at the Chongqing Medical University Affiliated Children's Hospital. METHODS: This study involved a retrospective review of the records of 61 pediatric patients who presented with testicular yolk sac tumor at our institution between 1995 and 2014. RESULTS: All patients presented with a painless scrotal mass. Serum alpha-fetoprotein (AFP) levels were elevated (n = 15)...
2014: World Journal of Surgical Oncology
Daniel Su, Izak Faiena, Robert Tokarz, Mark Bramwit, Robert E Weiss
OBJECTIVE: To evaluate the surveillance recommendations for early-stage testis cancer and the risk of secondary malignancies due to increased radiation exposure. MATERIALS AND METHODS: Using National Comprehensive Cancer Network (NCCN) guidelines 2012 and 2014 for early-stage testicular cancer, the numbers of abdominal and pelvic computed tomography scans (CTAPs) and chest radiographies were calculated, and lifetime attributable risk for secondary malignancy was estimated using Biologic Effects of Ionizing Radiation VII organ-specific model for solid organ malignancy based on the initial age of exposure...
January 2015: Urology
P Sidhu, P Lin, H Son, D Rosenfeld, M Lin
OBJECTIVE: This is the first case series examining the role of fluorine-18 fludeoxyglucose ((18)F-FDG) positron emission tomography-CT (PET-CT) in the diagnosis of lymphoma, and its impact on the clinical management of patients with secondary testicular involvement. This study explores the clinical significance of abnormal testicular uptake, maximum standardized uptake values and the diagnostic value of the CT component in PET-CT scans of these patients. METHODS: The case notes and PET scans of 12 patients with diagnosis of lymphoma that were reported to have abnormal (18)F-FDG uptake in the testes were examined...
December 2014: British Journal of Radiology
Zsófia Küronya, Hajnalka Németh, Lajos Géczi
Testicular cancer is the most common cancer in young males. Testicular cancer has one of the highest cure rates of all cancers: with modern chemotherapy treatment five-year survival rate exceeds 90 percent overall, and reaches almost 100 percent in early stages. However, these favorable results can only be achieved if these patients are transferred to a reference center, because better outcome was reported for patients who had been treated in a high volume center. Strict adherence to therapeutic protocol is vital for good results...
September 2014: Magyar Onkologia
Stephanie A Howard, Kathryn P Gray, Elizabeth K O'Donnell, Fiona M Fennessy, Clair J Beard, Christopher J Sweeney
OBJECTIVE: The purpose of this study was to investigate whether retroperitoneal craniocaudal nodal length or nodal volume predicts relapse risk in stage I testicular cancer. MATERIALS AND METHODS: We retrospectively reviewed 826 testicular cancer patients. Of these 826 patients, 118 had stage I disease and either less than 2 years of surveillance or retroperitoneal lymph node dissection with no adjuvant chemotherapy. These patients formed our analytic cohort, and 3D nodal volumes and craniocaudal nodal length were measured...
October 2014: AJR. American Journal of Roentgenology
Beenish Qureshi, Costantine Albany
A 30-year-old man presented with chest pressure, shortness of breath, severe dyspnea on exertion, dysphagia, odynophagia, and a weight loss of 30 lb (14 kg) over a 2-month period. He had undergone orchiectomy 3 years earlier for stage 1 testicular seminoma but had been lost to follow-up. Cardiac..
August 21, 2014: New England Journal of Medicine
P M Willemse, N A T Hamdy, M L de Kam, J Burggraaf, S Osanto
CONTEXT: Patients with germ cell tumors (GCTs) have an excellent prognosis but are at risk for silent fractures. Data on bone mineral density (BMD) after anticancer treatment are scarce. OBJECTIVE: The objective of the study was BMD monitoring in GCT patients treated with or without chemotherapy. DESIGN: We prospectively studied 63 newly diagnosed GCT patients with a median age of 33 years (range 16-70 y) within 3 months of unilateral orchidectomy...
November 2014: Journal of Clinical Endocrinology and Metabolism
F Zengerling, J Müller, S Krege, M Schrader
Currently, seminomas account for about 60% of newly diagnosed testicular cancers in Germany, with an increasing trend. In lower tumor stages the main focus is on the avoidance of over therapy. This is of special interest in stage I where radiotherapy, carboplatin monotherapy and surveillance are available therapies as well as in stage IIA/B. Due to high late toxicity, radiotherapy of the retroperitoneal space is obsolete for young patients with clinical stage I and, in its present form, discussed controversially for patients with clinical stage IIA/B...
April 2014: Der Urologe. Ausg. A
Natasha R Catlin, Susan M Huse, Kim Boekelheide
Testicular effects of chemical mixtures may differ from those of the individual chemical constituents. This study assessed the co-exposure effects of the model germ cell- and Sertoli cell-specific toxicants, X-irradiation (x-ray), and 2,5-hexanedione (HD), respectively. In high-dose studies, HD has been shown to attenuate x-ray-induced germ cell apoptosis. Adult rats were exposed to different levels of x-ray (0.5 Gy, 1 Gy, and 2 Gy) or HD (0.33%), either alone or in combination. To assess cell type-specific attenuation of x-ray effects with HD co-exposure, we used laser capture microdissection (LCM) to enrich the targeted cell population and examine a panel of apoptosis-related transcripts using PCR arrays...
December 2014: Toxicologic Pathology
Tullio Torelli, Giovanni Lughezzani, Mario Catanzaro, Nicola Nicolai, Maurizio Colecchia, Davide Biasoni, Luigi Piva, Massimo Maffezzini, Silvia Stagni, Andrea Necchi, Patrizia Giannatempo, Elena Farè, Roberto Salvioni
BACKGROUND: Prostatic metastases from testicular germ cell tumors (TGCTs) are extremely uncommon. To the best of our knowledge, only five cases of prostatic metastases from seminoma have been reported in the literature. Conversely, no cases of metastases to the prostate from nonseminomatous germ cell tumors (NSGCT) have been previously reported. CASE PRESENTATION: We present two patients who developed prostatic metastases 5 and 21 years after the initial diagnosis...
September 2013: Tumori
Katalin Borbély, Lajos Géczi, Miklós Kásler
The wide use of molecular positron emission tomography/computed tomography (PET/CT) imaging in the tumor diagnostics has been playing an important role recently. The clinical role of hybrid imaging (PET/CT, single photon ECT/CT (SPECT/CT)) is growing continuously due to the simultaneous imaging of anatomy and function. Regarding oncology the role of (18)F-fluorodeoxyglucose ((18)F-FDG) PET is proved in several clinical questions, including urooncology. Urologic cancers are associated with low or slightly significant uptake of FDG, due to their more benign behaviour...
December 2013: Magyar Onkologia
Sheng-Song Huang, Deng-Long Wu, Ya-Ping Gui, Xin Zhao, Hua Xie
OBJECTIVE: To study the clinical characteristics of yolk sac tumor of the testis with concomitant testicular hydrocele in children and the association between the two conditions in order to improve the diagnosis and treatment of the disease. METHODS: We retrospectively analyzed the clinical data of 7 cases of stage-I yolk sac tumor of the testis with concomitant testicular hydrocele. The patients ranged in age from 6 to 14 (mean 11) months. As treatment, we performed radical high spermatic cord orchiectomy after diagnosis established on intraoperative frozen sections, and conducted follow-up visits by medical examination, serum alpha-fetoprotein (AFP) detection, chest X-ray, ultrasonography and CT for 3-41 (mean 17) months, every month in the first year, every 3 months in the second year and every 6 months in the third year after surgery...
November 2013: Zhonghua Nan Ke Xue, National Journal of Andrology
Filip Y F L De Vos, Sasja F Mulder, Joost P H Drenth, Iris D Nagtegaal, Jurgen J Fütterer, Winette T A van der Graaf
BACKGROUND: Bleomycin has become an integral part of chemotherapy in patients with germ-cell tumors. One of the most feared side effects is bleomycin-induced pneumonitis. In patients with mild or moderate BIP, radiological signs disappear almost completely within nine months after discontinuation of bleomycin treatment. CASE PRESENTATION: We present a patient with a history of non seminoma of the testis and bleomycin-induced pneumonitis. During follow-up, regression of the hypothesis of eosinophilic migration to the liver after regression of bleomycin-induced pneumonitis is highly suspicious based on transient eosinophilia and focal eosinophilic liver disease...
2013: BMC Cancer
Luca Tagliabue, Angelo Del Sole
Positron emission tomography (PET) was developed in the mid-1970, and its initial applications were for heart and brain imaging research. Nowadays, this technology is aimed mainly at staging or restaging tumours as it allows the assessment of biochemical processes that are either specific or associated with tumour biology. The full appreciation of PET potentials and limitations among general practitioners and internists cannot be considered achieved and the appropriate use of PET especially when coupled to X-ray computed tomography (CT) is still suboptimal...
January 2014: European Journal of Internal Medicine
Peter Grimison, Baerin Houghton, Mark Chatfield, Guy C Toner, Ian D Davis, Jarad Martin, Elizabeth Hovey, Martin R Stockler
OBJECTIVE: To determine the patterns of management and surveillance imaging amongst medical oncologists in Australia for stage I testicular cancer during 2010. METHODS: We conducted a survey comprising 14 questions about the management strategy and surveillance imaging for all patients with stage I testicular cancer treated over the previous 12 months. RESULTS: A total of 52 medical oncologists documented the management for an estimated 470 patients...
July 2013: BJU International
Stefan Aufderklamm, Tilman Todenhöfer, Jörg Hennenlotter, Georgios Gakis, Johannes Mischinger, Jens Mundhenk, Miriam Germann, Arnulf Stenzl, Christian Schwentner
PURPOSE: Retroperitoneal lymph node dissection (RPLND) is performed in patients with advanced nonseminomatous (NSGCT) germ cell tumors and residual retroperitoneal mass post-chemotherapy. The extent of node dissection remains unclear. Ipsilateral template dissection is a compromise between morbidity and oncological efficacy. Here, we compare ipsilateral with primary bilateral laparoscopic (L)-RPLND after chemotherapy in terms of morbidity and oncological safety. PATIENTS AND METHODS: Nineteen laparoscopic ipsilateral L-RPLNDs (Group A) after platinum-based chemotherapy in patients with clinical stage IIA-III NSGCT were performed, while 20 patients underwent primary bilateral L-RPLND (Group B)...
July 2013: Journal of Endourology
Christopher L Hallemeier, Richard Choo, Brian J Davis, Bradley C Leibovich, Brian A Costello, Thomas M Pisansky
OBJECTIVES: The objectives of this study are to examine the long-term efficacy and adverse effects of adjuvant radiotherapy (RT) for stage I testicular seminoma. METHODS AND MATERIALS: A retrospective review was conducted in 199 patients with stage I testicular seminoma treated with curative intent orchiectomy and adjuvant megavoltage RT at the institution from January 1, 1972 through December 31, 2009. Computed tomography staging was performed for 90% of the patients...
January 2014: Urologic Oncology
Dong Jae Shin, Jeung Sook Kim, Do Yeun Kim, Jeong Seok Yeo
Patients with testicular seminoma are usually cured if they survive disease-free for 5 years after therapy. Late relapse can also occur but is rare. In particular, relapse of testicular seminoma in the form of a large mediastinal mass is extremely rare. We present here a 37-year-old man with a late relapse of a large testicular seminoma in the posterior mediastinum, encasing the descending thoracic aorta, and compressing the left atrium and left main bronchus on computed tomography (CT) and positron emission tomography (PET)...
March 2013: Clinical Imaging
Nidhi Verma, Suresh Babu, Jitendra Kumar Kushwaha, Atin Singhai
Metastasis of colorectal carcinoma to testis is rare. The authors report a case of 35-year-old man with right testicular mass. Contrast-enhanced CT scan (CECT) of testes showed testicular mass with ascitis and enlargement of retroperitoneal lymphnodes. Thus, a provisional diagnosis of disseminated primary testicular tumour was made. On subsequent high orchidectomy pathological examination revealed mucinous adenocarcinoma with CDX2 positivity thereby suggesting the possibility of metastasis from adenocarcinoma...
2013: BMJ Case Reports
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