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JOURNAL ARTICLE
Amanda Klein, Luke Kosinski, Alexandre Loupy, Eric Frey, Mark Stegall, Ilkka Helanterä, Kenneth Newell, Herwig-Ulf Meier-Kriesche, Roslyn B Mannon, William E Fitzsimmons
Biopsy-proven acute rejection (BPAR) occurs in approximately 10% of kidney transplant recipients in the first year making superiority trials unfeasible. IBOX, a quantitative composite of eGFR, proteinuria, anti-HLA DSA, and + full/- abbreviated kidney histopathology, is a new proposed surrogate endpoint. BPAR's prognostic ability was compared to iBOX in a pooled cohort of 1534 kidney transplant recipients from four datasets, including two prospective randomized controlled trials. Discrimination analyses showed mean c-statistic differences between both iBOX compared to BPAR of 0...
April 18, 2024: American Journal of Transplantation
#2
JOURNAL ARTICLE
Guilhem Lalle, Raphaëlle Lautraite, Khaled Bouherrou, Maud Plaschka, Aurora Pignata, Allison Voisin, Julie Twardowski, Marlène Perrin-Niquet, Pierre Stéphan, Sarah Durget, Laurie Tonon, Maude Ardin, Cyril Degletagne, Alain Viari, Laurence Belgarbi Dutron, Nathalie Davoust, Thomas S Postler, Jingyao Zhao, Christophe Caux, Julie Caramel, Stéphane Dalle, Philippe A Cassier, Ulf Klein, Marc Schmidt-Supprian, Roland Liblau, Sankar Ghosh, Yenkel Grinberg-Bleyer
The outcome of cancer and autoimmunity is often dictated by the effector functions of CD4+ conventional T cells (Tconv). Although activation of the NF-κB signaling pathway has long been implicated in Tconv biology, the cell-autonomous roles of the separate NF-κB transcription-factor subunits are unknown. Here, we dissected the contributions of the canonical NF-κB subunits RelA and c-Rel to Tconv function. RelA, rather than c-Rel, regulated Tconv activation and cytokine production at steady-state and was required for polarization toward the TH17 lineage in vitro...
June 3, 2024: Journal of Experimental Medicine
#3
JOURNAL ARTICLE
Allison Voisin, Maud Plaschka, Marlène Perrin-Niquet, Julie Twardowski, Insaf Boutemine, Baptiste Eluard, Guilhem Lalle, Pierre Stéphan, Khaled Bouherrou, Laurie Tonon, Roxane Pommier, Anthony Ferrari, Ulf Klein, Mélanie Wencker, Véronique Baud, Philippe A Cassier, Yenkel Grinberg-Bleyer
CD8+ T cells are critical mediators of pathogen clearance and anti-tumor immunity. Although signaling pathways leading to the activation of NF-κB transcription factors have crucial functions in the regulation of immune responses, the CD8+ T cell-autonomous roles of the different NF-κB subunits, are still unresolved. Here, we investigated the function of the ubiquitously expressed transcription factor RelA in CD8+ T-cell biology using a novel mouse model and gene-edited human cells. We found that CD8+ T cell-specific ablation of RelA markedly altered the transcriptome of ex vivo stimulated cells, but maintained the proliferative capacity of both mouse and human cells...
2024: Frontiers in Immunology
#4
JOURNAL ARTICLE
David Lohr, Arne Thiele, Max Stahnke, Vera M Braun, Robert Klopfleisch, Oliver Klein, Sandra Dresen, Ulf Landmesser, Anna Foryst-Ludwig, Ulrich Kintscher, Laura M Schreiber, Niklas Beyhoff
Anthracyclines are highly potent anti-cancer drugs, but their clinical use is limited by severe cardiotoxic side effects. The impact of anthracycline-induced cardiotoxicity (AIC) on left ventricular (LV) microarchitecture and diffusion properties remains unknown. This study sought to characterize AIC by cardiovascular magnetic resonance diffusion tensor imaging (DTI). Mice were treated with Doxorubicin (DOX; n = 16) for induction of AIC or saline as corresponding control (n = 15)...
March 14, 2024: Basic Research in Cardiology
#5
JOURNAL ARTICLE
Addressing climate change with behavioral science: A global intervention tournament in 63 countries.
Madalina Vlasceanu, Kimberly C Doell, Joseph B Bak-Coleman, Boryana Todorova, Michael M Berkebile-Weinberg, Samantha J Grayson, Yash Patel, Danielle Goldwert, Yifei Pei, Alek Chakroff, Ekaterina Pronizius, Karlijn L van den Broek, Denisa Vlasceanu, Sara Constantino, Michael J Morais, Philipp Schumann, Steve Rathje, Ke Fang, Salvatore Maria Aglioti, Mark Alfano, Andy J Alvarado-Yepez, Angélica Andersen, Frederik Anseel, Matthew A J Apps, Chillar Asadli, Fonda Jane Awuor, Flavio Azevedo, Piero Basaglia, Jocelyn J Bélanger, Sebastian Berger, Paul Bertin, Michał Białek, Olga Bialobrzeska, Michelle Blaya-Burgo, Daniëlle N M Bleize, Simen Bø, Lea Boecker, Paulo S Boggio, Sylvie Borau, Björn Bos, Ayoub Bouguettaya, Markus Brauer, Cameron Brick, Tymofii Brik, Roman Briker, Tobias Brosch, Ondrej Buchel, Daniel Buonauro, Radhika Butalia, Héctor Carvacho, Sarah A E Chamberlain, Hang-Yee Chan, Dawn Chow, Dongil Chung, Luca Cian, Noa Cohen-Eick, Luis Sebastian Contreras-Huerta, Davide Contu, Vladimir Cristea, Jo Cutler, Silvana D'Ottone, Jonas De Keersmaecker, Sarah Delcourt, Sylvain Delouvée, Kathi Diel, Benjamin D Douglas, Moritz A Drupp, Shreya Dubey, Jānis Ekmanis, Christian T Elbaek, Mahmoud Elsherif, Iris M Engelhard, Yannik A Escher, Tom W Etienne, Laura Farage, Ana Rita Farias, Stefan Feuerriegel, Andrej Findor, Lucia Freira, Malte Friese, Neil Philip Gains, Albina Gallyamova, Sandra J Geiger, Oliver Genschow, Biljana Gjoneska, Theofilos Gkinopoulos, Beth Goldberg, Amit Goldenberg, Sarah Gradidge, Simone Grassini, Kurt Gray, Sonja Grelle, Siobhán M Griffin, Lusine Grigoryan, Ani Grigoryan, Dmitry Grigoryev, June Gruber, Johnrev Guilaran, Britt Hadar, Ulf J J Hahnel, Eran Halperin, Annelie J Harvey, Christian A P Haugestad, Aleksandra M Herman, Hal E Hershfield, Toshiyuki Himichi, Donald W Hine, Wilhelm Hofmann, Lauren Howe, Enma T Huaman-Chulluncuy, Guanxiong Huang, Tatsunori Ishii, Ayahito Ito, Fanli Jia, John T Jost, Veljko Jovanović, Dominika Jurgiel, Ondřej Kácha, Reeta Kankaanpää, Jaroslaw Kantorowicz, Elena Kantorowicz-Reznichenko, Keren Kaplan Mintz, Ilker Kaya, Ozgur Kaya, Narine Khachatryan, Anna Klas, Colin Klein, Christian A Klöckner, Lina Koppel, Alexandra I Kosachenko, Emily J Kothe, Ruth Krebs, Amy R Krosch, Andre P M Krouwel, Yara Kyrychenko, Maria Lagomarsino, Claus Lamm, Florian Lange, Julia Lee Cunningham, Jeffrey Lees, Tak Yan Leung, Neil Levy, Patricia L Lockwood, Chiara Longoni, Alberto López Ortega, David D Loschelder, Jackson G Lu, Yu Luo, Joseph Luomba, Annika E Lutz, Johann M Majer, Ezra Markowitz, Abigail A Marsh, Karen Louise Mascarenhas, Bwambale Mbilingi, Winfred Mbungu, Cillian McHugh, Marijn H C Meijers, Hugo Mercier, Fenant Laurent Mhagama, Katerina Michalakis, Nace Mikus, Sarah Milliron, Panagiotis Mitkidis, Fredy S Monge-Rodríguez, Youri L Mora, David Moreau, Kosuke Motoki, Manuel Moyano, Mathilde Mus, Joaquin Navajas, Tam Luong Nguyen, Dung Minh Nguyen, Trieu Nguyen, Laura Niemi, Sari R R Nijssen, Gustav Nilsonne, Jonas P Nitschke, Laila Nockur, Ritah Okura, Sezin Öner, Asil Ali Özdoğru, Helena Palumbo, Costas Panagopoulos, Maria Serena Panasiti, Philip Pärnamets, Mariola Paruzel-Czachura, Yuri G Pavlov, César Payán-Gómez, Adam R Pearson, Leonor Pereira da Costa, Hannes M Petrowsky, Stefan Pfattheicher, Nhat Tan Pham, Vladimir Ponizovskiy, Clara Pretus, Gabriel G Rêgo, Ritsaart Reimann, Shawn A Rhoads, Julian Riano-Moreno, Isabell Richter, Jan Philipp Röer, Jahred Rosa-Sullivan, Robert M Ross, Anandita Sabherwal, Toshiki Saito, Oriane Sarrasin, Nicolas Say, Katharina Schmid, Michael T Schmitt, Philipp Schoenegger, Christin Scholz, Mariah G Schug, Stefan Schulreich, Ganga Shreedhar, Eric Shuman, Smadar Sivan, Hallgeir Sjåstad, Meikel Soliman, Katia Soud, Tobia Spampatti, Gregg Sparkman, Ognen Spasovski, Samantha K Stanley, Jessica A Stern, Noel Strahm, Yasushi Suko, Sunhae Sul, Stylianos Syropoulos, Neil C Taylor, Elisa Tedaldi, Gustav Tinghög, Luu Duc Toan Huynh, Giovanni Antonio Travaglino, Manos Tsakiris, İlayda Tüter, Michael Tyrala, Özden Melis Uluğ, Arkadiusz Urbanek, Danila Valko, Sander van der Linden, Kevin van Schie, Aart van Stekelenburg, Edmunds Vanags, Daniel Västfjäll, Stepan Vesely, Jáchym Vintr, Marek Vranka, Patrick Otuo Wanguche, Robb Willer, Adrian Dominik Wojcik, Rachel Xu, Anjali Yadav, Magdalena Zawisza, Xian Zhao, Jiaying Zhao, Dawid Żuk, Jay J Van Bavel
Effectively reducing climate change requires marked, global behavior change. However, it is unclear which strategies are most likely to motivate people to change their climate beliefs and behaviors. Here, we tested 11 expert-crowdsourced interventions on four climate mitigation outcomes: beliefs, policy support, information sharing intention, and an effortful tree-planting behavioral task. Across 59,440 participants from 63 countries, the interventions' effectiveness was small, largely limited to nonclimate skeptics, and differed across outcomes: Beliefs were strengthened mostly by decreasing psychological distance (by 2...
February 9, 2024: Science Advances
#6
JOURNAL ARTICLE
Marie Cathrine Wolf, Peter Klein, Ulf Kulau, Christoph Richter, Klaus-Hendrik Wolf
The DR.BEAT project aims at the further development of a measurement system for recording ballistocardiographic signals into a body-worn sensor system combined with extensive signal processing, data evaluation and visualization. With a first breadboard prototype, an explorative feasibility study for acquiring initial signals of healthy cardiac activity in adults was performed. This paper briefly presents the DR.BEAT project, the breadboard prototype, the study conducted, and initial insights into the study results...
July 2023: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
#7
JOURNAL ARTICLE
Matthias Zehner, Mira Alt, Artem Ashurov, Jory A Goldsmith, Rebecca Spies, Nina Weiler, Justin Lerma, Lutz Gieselmann, Dagmar Stöhr, Henning Gruell, Eric P Schultz, Christoph Kreer, Linda Schlachter, Hanna Janicki, Kerstin Laib Sampaio, Cora Stegmann, Michelle D Nemetchek, Sabrina Dähling, Leon Ullrich, Ulf Dittmer, Oliver Witzke, Manuel Koch, Brent J Ryckman, Ramin Lotfi, Jason S McLellan, Adalbert Krawczyk, Christian Sinzger, Florian Klein
Human cytomegalovirus (HCMV) can cause severe diseases in fetuses, newborns, and immunocompromised individuals. Currently, no vaccines are approved, and treatment options are limited. Here, we analyzed the human B cell response of four HCMV top neutralizers from a cohort of 9,000 individuals. By single-cell analyses of memory B cells targeting the pentameric and trimeric HCMV surface complexes, we identified vulnerable sites on the shared gH/gL subunits as well as complex-specific subunits UL128/130/131A and gO...
November 14, 2023: Immunity
#8
JOURNAL ARTICLE
Amanda Klein, Alexandre Loupy, Mark Stegall, Ilkka Helanterä, Luke Kosinski, Eric Frey, Olivier Aubert, Gillian Divard, Kenneth Newell, Herwig-Ulf Meier-Kriesche, Roslyn Mannon, Thomas Dumortier, Varun Aggarwal, Jagdeep T Podichetty, Inish O'Doherty, Ahmed Osama Gaber, William E Fitzsimmons
New immunosuppressive therapies that improve long-term graft survival are needed in kidney transplant. Critical Path Institute's Transplant Therapeutics Consortium received a qualification opinion for the iBOX Scoring System as a novel secondary efficacy endpoint for kidney transplant clinical trials through European Medicines Agency's qualification of novel methodologies for drug development. This is the first qualified endpoint for any transplant indication and is now available for use in kidney transplant clinical trials...
2023: Transplant International
#9
JOURNAL ARTICLE
Amanda Klein, Alexandre Loupy, Mark Stegall, Ilkka Helanterä, Luke Kosinski, Eric Frey, Olivier Aubert, Gillian Divard, Kenneth Newell, Herwig-Ulf Meier-Kriesche, Roslyn B Mannon, Thomas Dumortier, Varun Aggarwal, Jagdeep T Podichetty, Inish O'Doherty, Ahmed Osama Gaber, William E Fitzsimmons
New immunosuppressive therapies that improve long-term graft survival are needed in kidney transplant. Critical Path Institute's Transplant Therapeutics Consortium received a qualification opinion for the iBOX Scoring System as a novel secondary efficacy endpoint for kidney transplant clinical trials through European Medicines Agency's qualification of novel methodologies for drug development. This is the first qualified endpoint for any transplant indication and is now available for use in kidney transplant clinical trials...
October 2023: American Journal of Transplantation
#10
JOURNAL ARTICLE
Jasper Vöckel, Ulf Thiemann, Matthias Weisbrod, Johannes Schröder, Franz Resch, Christoph Klein, Stephan Bender
OBJECTIVE: Despite extensive research, the etiology of negative symptoms is not well understood. Preliminary findings are linking motor disturbances to negative symptom severity. We aimed to further the understanding to what extent motor movement preparation influences negative symptom severity. METHODS: In a cohort of 31 subjects with schizophrenia and 20 control subjects we recorded the readiness potential amplitude over Cz during spontaneous movements of the right and left thumb...
August 3, 2023: Schizophrenia Research
#11
JOURNAL ARTICLE
Rebecca J Brownlie, Ulf Klein
No abstract text is available yet for this article.
June 26, 2023: Nature Immunology
#12
EDITORIAL
Erica B Wilson, Ulf Klein
In this issue of Blood Cancer Discovery, Nakanishi et al. uncover a critical role for the elevated activity of the translation initiation factor eIF5A in the malignant growth of MYC-driven lymphoma. eIF5A is posttranslationally modified by hypusination through MYC oncoprotein-mediated hyperactivation of the polyamine-hypusine circuit, which may represent a promising therapeutic target because an enzyme of this circuit that is required for hypusinating eIF5A proved to be essential for lymphoma development. See related article by Nakanishi et al...
June 14, 2023: Blood cancer discovery
#13
JOURNAL ARTICLE
Felix Dewald, Martin Pirkl, Martha Paluschinski, Joachim Kühn, Carina Elsner, Bianca Schulte, Jacqueline Knüfer, Elvin Ahmadov, Maike Schlotz, Göksu Oral, Michael Bernhard, Mark Michael, Maura Luxenburger, Marcel Andrée, Marc Tim Hennies, Wali Hafezi, Marlin Maybrit Müller, Philipp Kümpers, Joachim Risse, Clemens Kill, Randi Katrin Manegold, Ute von Frantzki, Enrico Richter, Dorian Emmert, Werner O Monzon-Posadas, Ingo Gräff, Monika Kogej, Antonia Büning, Maximilian Baum, Finn Teipel, Babak Mochtarzadeh, Martin Wolff, Henning Gruell, Veronica Di Cristanziano, Volker Burst, Hendrik Streeck, Ulf Dittmer, Stephan Ludwig, Jörg Timm, Florian Klein
Determining SARS-CoV-2 immunity is critical to assess COVID-19 risk and the need for prevention and mitigation strategies. We measured SARS-CoV-2 Spike/Nucleocapsid seroprevalence and serum neutralizing activity against Wu01, BA.4/5 and BQ.1.1 in a convenience sample of 1,411 patients receiving medical treatment in the emergency departments of five university hospitals in North Rhine-Westphalia, Germany, in August/September 2022. 62% reported underlying medical conditions and 67.7% were vaccinated according to German COVID-19 vaccination recommendations (13...
May 19, 2023: Nature Communications
#14
JOURNAL ARTICLE
Henry Kim, Nathalie Weidner, Céline Ronin, Emmanuel Klein, James A Roper, Barbro Kahl-Knutson, Kristoffer Peterson, Hakon Leffler, Ulf J Nilsson, Anders Pedersen, Fredrik R Zetterberg, Robert J Slack
Galectin-3 is a beta-galactoside-binding mammalian lectin that is one of a 15-member galectin family that can bind several cell surface glycoproteins via its carbohydrate recognition domain (CRD). As a result, it can influence a range of cellular processes including cell activation, adhesion and apoptosis. Galectin-3 has been implicated in various diseases, including fibrotic disorders and cancer, and is now being therapeutically targeted by both small and large molecules. Historically, the screening and triaging of small molecule glycomimetics that bind to the galectin-3 CRD has been completed in fluorescence polarisation (FP) assays to determine KD values...
March 27, 2023: SLAS Discovery
#15
JOURNAL ARTICLE
Rebecca J Brownlie, Ruth Kennedy, Erica B Wilson, Maja Milanovic, Claire F Taylor, Dapeng Wang, John Davies, Heather Elizabeth Owston, Emma J Adams, Sophie Stephenson, Rebecca Caeser, Benjamin E Gewurz, Peter V Giannoudis, Claudio Scuoppo, Dennis McGonagle, Daniel J Hodson, Reuben M Tooze, Gina M Doody, Gordon Cook, David R Westhead, Ulf Klein
Multiple myeloma (MM) shows constitutive activation of canonical and non-canonical nuclear factor-ĸB (NF-ĸB) signaling through genetic mutations or stimuli from the tumour microenvironment (TME). A subset of MM cell lines showed dependency for cell growth and survival on the canonical NF-ĸB transcription factor RELA alone, suggesting a critical role for a RELA-mediated biological program in MM pathogenesis. Here, we determined the RELA-dependent transcriptional program in MM cell lines and found the expression of the cell surface molecules IL-27 receptor-α (IL-27Rα) and the adhesion molecule JAM2 to be responsive to RELA at the mRNA and protein levels...
March 3, 2023: Blood Advances
#16
JOURNAL ARTICLE
Larissa Henze, Julian Braun, Lil Meyer-Arndt, Karsten Jürchott, Maike Schlotz, Janine Michel, Marica Grossegesse, Maike Mangold, Manuela Dingeldey, Beate Kruse, Pavlo Holenya, Norbert Mages, Ulf Reimer, Maren Eckey, Karsten Schnatbaum, Holger Wenschuh, Bernd Timmermann, Florian Klein, Andreas Nitsche, Claudia Giesecke-Thiel, Lucie Loyal, Andreas Thiel
Currently available COVID-19 vaccines include inactivated virus, live attenuated virus, mRNA-based, viral vectored and adjuvanted protein-subunit-based vaccines. All of them contain the spike glycoprotein as the main immunogen and result in reduced disease severity upon SARS-CoV-2 infection. While we and others have shown that mRNA-based vaccination reactivates pre-existing, cross-reactive immunity, the effect of vector vaccines in this regard is unknown. Here, we studied cellular and humoral responses in heterologous adenovirus-vector-based ChAdOx1 nCOV-19 (AZ; Vaxzeria, AstraZeneca) and mRNA-based BNT162b2 (BNT; Comirnaty, BioNTech/Pfizer) vaccination and compared it to a homologous BNT vaccination regimen...
2023: Frontiers in Immunology
#17
JOURNAL ARTICLE
Vera Wilke, Mihaly Sulyok, Maria-Ioanna Stefanou, Vivien Richter, Benjamin Bender, Ulrike Ernemann, Ulf Ziemann, Nisar Malek, Katharina Kienzle, Constantin Klein, Stefanie Bunk, Siri Goepel, Annerose Mengel
INTRODUCTION: Delirium is recognized as a severe complication of coronavirus-disease-2019 (COVID-19). COVID-19-associated delirium has been linked to worse patient outcomes and is considered to be of multifactorial origin. Here we sought to evaluate the incidence and risk factors of delirium in hospitalized COVID-19 patients, along with its impact on clinical outcome. METHODS: Consecutive adult COVID-19 patients admitted to a tertiary academic referral hospital between March 1st and December 31st, 2020 were included...
2022: PloS One
#18
REVIEW
Laura Pasqualucci, Ulf Klein
Most B cell lymphomas arise from the oncogenic transformation of B cells that have undergone the germinal center (GC) reaction of the T cell-dependent immune response, where high-affinity memory B cells and plasma cells are generated. The high proliferation of GC B cells coupled with occasional errors in the DNA-modifying processes of somatic hypermutation and class switch recombination put the cell at a risk to obtain transforming genetic aberrations, which may activate proto-oncogenes or inactivate tumour suppressor genes...
October 1, 2022: Biomedicines
#19
JOURNAL ARTICLE
Frauke Degenhardt, David Ellinghaus, Simonas Juzenas, Jon Lerga-Jaso, Mareike Wendorff, Douglas Maya-Miles, Florian Uellendahl-Werth, Hesham ElAbd, Malte C Rühlemann, Jatin Arora, Onur Özer, Ole Bernt Lenning, Ronny Myhre, May Sissel Vadla, Eike M Wacker, Lars Wienbrandt, Aaron Blandino Ortiz, Adolfo Salazar, Adolfo Garrido Chercoles, Adriana Palom, Agustín Ruiz, Alba-Estela Garcia-Fernandez, Albert Blanco-Grau, Alberto Mantovani, Alberto Zanella, Aleksander Rygh Holten, Alena Mayer, Alessandra Bandera, Alessandro Cherubini, Alessandro Protti, Alessio Aghemo, Alessio Gerussi, Alfredo Ramirez, Alice Braun, Almut Nebel, Ana Barreira, Ana Lleo, Ana Teles, Anders Benjamin Kildal, Andrea Biondi, Andrea Caballero-Garralda, Andrea Ganna, Andrea Gori, Andreas Glück, Andreas Lind, Anja Tanck, Anke Hinney, Anna Carreras Nolla, Anna Ludovica Fracanzani, Anna Peschuck, Annalisa Cavallero, Anne Ma Dyrhol-Riise, Antonella Ruello, Antonio Julià, Antonio Muscatello, Antonio Pesenti, Antonio Voza, Ariadna Rando-Segura, Aurora Solier, Axel Schmidt, Beatriz Cortes, Beatriz Mateos, Beatriz Nafria-Jimenez, Benedikt Schaefer, Björn Jensen, Carla Bellinghausen, Carlo Maj, Carlos Ferrando, Carmen Horra, Carmen Quereda, Carsten Skurk, Charlotte Thibeault, Chiara Scollo, Christian Herr, Christoph D Spinner, Christoph Gassner, Christoph Lange, Cinzia Hu, Cinzia Paccapelo, Clara Lehmann, Claudio Angelini, Claudio Cappadona, Clinton Azuure, Cristiana Bianco, Cristina Cea, Cristina Sancho, Dag Arne Lihaug Hoff, Daniela Galimberti, Daniele Prati, David Haschka, David Jiménez, David Pestaña, David Toapanta, Eduardo Muñiz-Diaz, Elena Azzolini, Elena Sandoval, Eleonora Binatti, Elio Scarpini, Elisa T Helbig, Elisabetta Casalone, Eloisa Urrechaga, Elvezia Maria Paraboschi, Emanuele Pontali, Enric Reverter, Enrique J Calderón, Enrique Navas, Erik Solligård, Ernesto Contro, Eunate Arana-Arri, Fátima Aziz, Federico Garcia, Félix García Sánchez, Ferruccio Ceriotti, Filippo Martinelli-Boneschi, Flora Peyvandi, Florian Kurth, Francesco Blasi, Francesco Malvestiti, Francisco J Medrano, Francisco Mesonero, Francisco Rodriguez-Frias, Frank Hanses, Fredrik Müller, Georg Hemmrich-Stanisak, Giacomo Bellani, Giacomo Grasselli, Gianni Pezzoli, Giorgio Costantino, Giovanni Albano, Giulia Cardamone, Giuseppe Bellelli, Giuseppe Citerio, Giuseppe Foti, Giuseppe Lamorte, Giuseppe Matullo, Guido Baselli, Hayato Kurihara, Holger Neb, Ilaria My, Ingo Kurth, Isabel Hernández, Isabell Pink, Itziar Rojas, Iván Galván-Femenia, Jan Cato Holter, Jan Egil Afset, Jan Heyckendorf, Jan Kässens, Jan Kristian Damås, Jan Rybniker, Janine Altmüller, Javier Ampuero, Javier Martín, Jeanette Erdmann, Jesus M Banales, Joan Ramon Badia, Joaquin Dopazo, Jochen Schneider, Jonas Bergan, Jordi Barretina, Jörn Walter, Jose Hernández Quero, Josune Goikoetxea, Juan Delgado, Juan M Guerrero, Julia Fazaal, Julia Kraft, Julia Schröder, Kari Risnes, Karina Banasik, Karl Erik Müller, Karoline I Gaede, Koldo Garcia-Etxebarria, Kristian Tonby, Lars Heggelund, Laura Izquierdo-Sanchez, Laura Rachele Bettini, Lauro Sumoy, Leif Erik Sander, Lena J Lippert, Leonardo Terranova, Lindokuhle Nkambule, Lisa Knopp, Lise Tuset Gustad, Lucia Garbarino, Luigi Santoro, Luis Téllez, Luisa Roade, Mahnoosh Ostadreza, Maider Intxausti, Manolis Kogevinas, Mar Riveiro-Barciela, Marc M Berger, Marco Schaefer, Mari E K Niemi, María A Gutiérrez-Stampa, Maria Carrabba, Maria E Figuera Basso, Maria Grazia Valsecchi, María Hernandez-Tejero, Maria J G T Vehreschild, Maria Manunta, Marialbert Acosta-Herrera, Mariella D'Angiò, Marina Baldini, Marina Cazzaniga, Marit M Grimsrud, Markus Cornberg, Markus M Nöthen, Marta Marquié, Massimo Castoldi, Mattia Cordioli, Maurizio Cecconi, Mauro D'Amato, Max Augustin, Melissa Tomasi, Mercè Boada, Michael Dreher, Michael J Seilmaier, Michael Joannidis, Michael Wittig, Michela Mazzocco, Michele Ciccarelli, Miguel Rodríguez-Gandía, Monica Bocciolone, Monica Miozzo, Natale Imaz Ayo, Natalia Blay, Natalia Chueca, Nicola Montano, Nicole Braun, Nicole Ludwig, Nikolaus Marx, Nilda Martínez, Oliver A Cornely, Oliver Witzke, Orazio Palmieri, Paola Faverio, Paoletta Preatoni, Paolo Bonfanti, Paolo Omodei, Paolo Tentorio, Pedro Castro, Pedro M Rodrigues, Pedro Pablo España, Per Hoffmann, Philip Rosenstiel, Philipp Schommers, Phillip Suwalski, Raúl Pablo, Ricard Ferrer, Robert Bals, Roberta Gualtierotti, Rocío Gallego-Durán, Rosa Nieto, Rossana Carpani, Rubén Morilla, Salvatore Badalamenti, Sammra Haider, Sandra Ciesek, Sandra May, Sara Bombace, Sara Marsal, Sara Pigazzini, Sebastian Klein, Serena Pelusi, Sibylle Wilfling, Silvano Bosari, Sonja Volland, Søren Brunak, Soumya Raychaudhuri, Stefan Schreiber, Stefanie Heilmann-Heimbach, Stefano Aliberti, Stephan Ripke, Susanne Dudman, Tanja Wesse, Tenghao Zheng, Thomas Bahmer, Thomas Eggermann, Thomas Illig, Thorsten Brenner, Tomas Pumarola, Torsten Feldt, Trine Folseraas, Trinidad Gonzalez Cejudo, Ulf Landmesser, Ulrike Protzer, Ute Hehr, Valeria Rimoldi, Valter Monzani, Vegard Skogen, Verena Keitel, Verena Kopfnagel, Vicente Friaza, Victor Andrade, Victor Moreno, Wolfgang Albrecht, Wolfgang Peter, Wolfgang Poller, Xavier Farre, Xiaoli Yi, Xiaomin Wang, Yascha Khodamoradi, Zehra Karadeniz, Anna Latiano, Siegfried Goerg, Petra Bacher, Philipp Koehler, Florian Tran, Heinz Zoller, Eva C Schulte, Bettina Heidecker, Kerstin U Ludwig, Javier Fernández, Manuel Romero-Gómez, Agustín Albillos, Pietro Invernizzi, Maria Buti, Stefano Duga, Luis Bujanda, Johannes R Hov, Tobias L Lenz, Rosanna Asselta, Rafael Cid, Luca Valenti, Tom H Karlsen, Mario Cáceres, Andre Franke
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome...
July 15, 2022: Human Molecular Genetics
#20
JOURNAL ARTICLE
Lil Meyer-Arndt, Julian Braun, Florent Fauchere, Kanika Vanshylla, Lucie Loyal, Larissa Henze, Beate Kruse, Manuela Dingeldey, Karsten Jürchott, Maike Mangold, Ardit Maraj, Andre Braginets, Chotima Böttcher, Andreas Nitsche, Kathrin de la Rosa, Christoph Ratswohl, Birgit Sawitzki, Pavlo Holenya, Ulf Reimer, Leif E Sander, Florian Klein, Friedemann Paul, Judith Bellmann-Strobl, Andreas Thiel, Claudia Giesecke-Thiel
BACKGROUND: SARS-CoV-2 mRNA vaccination of healthy individuals is highly immunogenic and protective against severe COVID-19. However, there are limited data on how disease-modifying therapies (DMTs) alter SARS-CoV-2 mRNA vaccine immunogenicity in patients with autoimmune diseases. METHODS: As part of a prospective cohort study, we investigated the induction, stability and boosting of vaccine-specific antibodies, B cells and T cells in patients with multiple sclerosis (MS) on different DMTs after homologous primary, secondary and booster SARS-CoV-2 mRNA vaccinations...
July 14, 2022: Journal of Neurology, Neurosurgery, and Psychiatry
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