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https://www.readbyqxmd.com/read/28864242/thymosin-%C3%AE-4-for-the-treatment-of-acute-stroke-in-aged-rats
#1
Daniel C Morris, Wing Lee Cheung, Richard Loi, Talan Zhang, Mei Lu, Zheng G Zhang, Michael Chopp
Thymosin β4 (Tβ4) is a 5K peptide which influences cellular migration by inhibiting organization of the actin-cytoskeleton. Tβ4 has neurorestorative properties and is a potential candidate for the treatment of sub-acute stroke. Previous research demonstrated that Tβ4 improved neurological outcome in a young (3 months) rat model of embolic stroke. We hypothesized that Tβ4 would improve neurological outcome in an aged rat model of embolic stroke when administered 24h after embolic stroke. Aged Male Wistar rats (Charles River, France 18-21 months) were subjected to embolic middle cerebral artery occlusion (MCAo)...
August 31, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28857257/mir-200a-mediates-protection-of-thymosin-beta-4-in-cardiac-microvascular-endothelial-cells-as-a-novel-mechanism-under-hypoxia-reoxygenation-injury
#2
Yang Li, Xiaolong Zhu, Xiping Liu, Aolin Du, Bo Yu
Thymosin beta-4 (Tβ4) is a ubiquitous protein, which has been suggested to regulate multiple cell signal pathways and a variety of cellular functions. However, the role Tβ4 plays in the cardiac microvascular endothelial cells (CMECs) under myocardial ischemia/reperfusion injury (MIRI) is currently unknown. Here we investigated the effects of Tβ4 on hypoxia/reoxygenation (H/R) induced CMECs injury and its potential molecular mechanism. Cultured CMECs were positively identified by flow cytometry using antibody against CD31 and VWF/Factor VIII, which are constitutively expressed on the surface of CMECs...
August 31, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28831179/global-proteomics-based-identification-and-validation-of-thymosin-beta-4-x-linked-as-a-prognostic-marker-for-head-and-neck-squamous-cell-carcinoma
#3
Li-Hsing Chi, Wei-Min Chang, Yu-Chan Chang, Yung-Chieh Chan, Chia-Chen Tai, Kam-Wing Leung, Chi-Long Chen, Alexander Th Wu, Tsung-Ching Lai, Yu-Chuan Jack Li, Michael Hsiao
Head and neck squamous cell carcinoma (HNSCC) represents a major health concern worldwide. We applied the matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) to analyze paired normal (N) and tumor (T) samples from head and neck squamous cell carcinoma as well as liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis in HNSCC cell lines to identify tumor-associated biomarkers. Our results showed a number of proteins found to be over-expressed in HNSCC. We identified thymosin beta-4 X-linked (TMSB4X) is one of the most significant candidate biomarkers...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808568/thymosin-%C3%AE-4-in-rheumatoid-arthritis-friend-or-foe
#4
Kyoung Soo Kim, Hyung-In Yang
Rheumatoid arthritis (RA) has characteristic pannus tissues, which show tumor-like growth of the synovium through chronic joint inflammation. The synovium is highly penetrated by various immune cells, and the synovial lining becomes hyperplastic due to increased numbers of macrophage-like and fibroblast-like synoviocytes. Thus, a resultant hypoxic condition stimulates the expression of inflammation-related genes in various cells, in particular, vascular endothelial growth factor. Thymosin β4 (Tβ4), a 5-kDa protein, is known to play a significant role in various biological activities, such as actin sequestering, cell motility, migration, inflammation, and damage repair...
September 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28803959/thymosin-%C3%AE-4-is-involved-in-the-antimicrobial-immune-response-of-golden-pompano-trachinotus-ovatus
#5
Yun Sun, Xiaojuan Chen, Yue Xu, Qiaohong Liu, Xue Jiang, Shifeng Wang, Weiliang Guo, Yongcan Zhou
Thymosin beta belongs to the thymosin family, which consists of a series of highly conserved peptides involved in various biological processes. In teleosts, understanding of the immunological functions of thymosin beta is limited, particularly in vivo, which is essentially unknown. In the current study, we cloned and identified thymosin beta 4 from the teleost fish Golden pompano (Trachinotus ovatus), which we have named TroTβ4. We investigated the expression patterns and functions of TroTβ4 in both in vivo and in vitro assays...
August 10, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28780644/immunopotentiator-thymosin-alpha-1-promotes-neurogenesis-and-cognition-in-the-developing-mouse-via-a-systemic-th1-bias
#6
Ge Wang, Fen He, Yunlong Xu, Yuwei Zhang, Xiao Wang, Chunhua Zhou, Yihong Huang, Juntao Zou
In early life, the immune system plays an essential role in brain development. In our study, the immunopotentiator thymosin alpha-1 (Ta1) was peripherally administered to neonatal mice to explore whether the peripheral immunopotentiator affects neurodevelopment and cognition, and to further investigate the relevant mechanism. Compared with the control group, the Ta1 mice displayed better cognitive abilities in early life. The numbers of 5-bromodeoxyuridine (BrdU)+, nestin+, T-box transcription factor 2 (Tbr2)+, BrdU+/doublecortin (DCX)+, BrdU+/ionized calcium-binding adaptor molecule 1 (Iba1)+, and BrdU+/neuronal nuclei (NeuN)+ cells in the hippocampus were increased in the Ta1 group, accompanied by increased interleukin-4 (IL-4), interferon-gamma, brain-derived neurotrophic factor, nerve growth factor, and insulin-like growth factor-1 as well as decreased IL-6 and tumor necrosis factor-α...
August 5, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28765877/investigation-of-the-immunomodulatory-activity-of-tricholoma%C3%A2-matsutake-mycelium-in-cyclophosphamide-induced-immunosuppressed-mice
#7
Quan Li, Yanzhen Wang, Yiling Chen, Meiyu Teng, Jian He, Xiaohan Wang, Fange Kong, Lirong Teng, Di Wang
Tricholoma matsutake, a popular food and biopharmaceutical resource in Asia, possesses various pharmacological activities. Although T. matsutake mycelium (TM) may enhance immunity, previous studies, to the best of our knowledge, have been performed on normal animals or cells alone. The present study aimed to evaluate the immunomodulatory activity of TM at doses of 0.3, 1.0 and 2.0 g/kg in cyclophosphamide (CTX)‑induced immunosuppressed mouse models. TM treatment for 2 weeks markedly improved the gain in bodyweight, increased organ indices, reduced hind paw swelling and positively regulated the cytotoxicity of natural killer cells and the proliferation of lymphocytes...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28758666/maldi-ms-imaging-investigation-of-the-host-response-to-visceral-leishmaniasis
#8
C F Jaegger, F Negrão, D M Assis, K R A Belaz, C F F Angolini, A M A P Fernandes, V G Santos, A Pimentel, D R Abánades, S Giorgio, M N Eberlin, D F O Rocha
Mass spectrometry imaging (MSI) of animal tissues has become an important tool for in situ molecular analyses and biomarker studies in several clinical areas, but there are few applications in parasitological studies. Leishmaniasis is a neglected tropical disease, and experimental mouse models have been essential to evaluate pathological and immunological processes and to develop diagnostic methods. Herein we have employed MALDI MSI to examine peptides and low molecular weight proteins (2 to 20 kDa) differentially expressed in the liver during visceral leishmaniasis in mice models...
July 31, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28756979/thymosin-beta-4-overexpression-correlates-with-high-risk-groups-in-gastric-gastrointestinal-stromal-tumors-a-retrospective-analysis-by-immunohistochemistry
#9
Sevinç Şahin, Ozgur Ekinci, Selda Seçkin, Ayse Dursun
BACKGROUND: Thymosin beta-4 (Tβ4) is a protein that is linked to a number of important biological actions and recently tumor progression and poor prognosis of some tumors. The aim of this study was to evaluate Tβ4 expression in gastric GISTs and correlate with some clinicopathological characteristics related with prognosis and clinical outcome in order to add further data to the current literature. METHODS: Tβ4 antibody was applied to the 4μm-thick paraffin sections of 57 gastric GISTs by immunohistochemistry...
July 6, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28737171/brg1-swi-snf-dependent-regulation-of-the-wt1-transcriptional-landscape-mediates-epicardial-activity-during-heart-development-and-disease
#10
Joaquim Miguel Vieira, Sara Howard, Cristina Villa Del Campo, Sveva Bollini, Karina N Dubé, Megan Masters, Damien N Barnette, Mala Rohling, Xin Sun, Laura E Hankins, Daria Gavriouchkina, Ruth Williams, Daniel Metzger, Pierre Chambon, Tatjana Sauka-Spengler, Benjamin Davies, Paul R Riley
Epicardium-derived cells (EPDCs) contribute cardiovascular cell types during development and in adulthood respond to Thymosin β4 (Tβ4) and myocardial infarction (MI) by reactivating a fetal gene programme to promote neovascularization and cardiomyogenesis. The mechanism for epicardial gene (re-)activation remains elusive. Here we reveal that BRG1, the essential ATPase subunit of the SWI/SNF chromatin-remodelling complex, is required for expression of Wilms' tumour 1 (Wt1), fetal EPDC activation and subsequent differentiation into coronary smooth muscle, and restores Wt1 activity upon MI...
July 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28726522/steerable-induction-of-the-thymosin-%C3%A3-4-mrtf-a-pathway-via-aav-based-overexpression-induces-therapeutic-neovascularization
#11
Tilman Ziegler, Markus Kraus, Wira Husada, Florian Gesenhues, Qui Jiang, Olaf Pinkenburg, Teresa Trenkwalder, Karl-Ludwig Laugwitz, Ferdinand le Noble, Christian Weber, Christian Kupatt, Rabea Hinkel
Viral vectors have been frequently used in a variety of preclinical animal models to deliver genetic constructs into tissues. Among the vectors used, adeno-associated viral vectors (AAVs) may be targeted to specific tissues, depending on the serotype used. Moreover, they show robust expression for prolonged periods of time and have a low immunogenic potential. Furthermore, AAVs, unlike other vector systems, only display a low rate of genomic integration. However, to ensure efficient transgene production, expression is typically driven by constitutively active promoters, such as the CMV promotor...
July 20, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28724974/effects-of-exogenous-thymosin-%C3%AE-4-on-carbon-tetrachloride-induced-liver-injury-and-fibrosis
#12
Xiankui Li, Lei Wang, Cai Chen
The present study investigated the effects of exogenous thymosin β4 (TB4) on carbon tetrachloride (CCl4)-induced acute liver injury and fibrosis in rodent animals. Results showed that both in mice and rats CCl4 rendered significant increases in serum alanine aminotransferase and aspartate aminotransferase, hepatic malondialdehyde formation, decreases in antioxidants including superoxide dismutase and glutathione, and up-regulated expressions of transforming growth factor-β1, α-smooth muscle actin, tumor necrosis factor-α and interleukin-1β in the liver tissues...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28719851/interaction-of-cholera-toxin-b-subunit-with-t-and-b-lymphocytes
#13
Elena V Navolotskaya, Vladimir B Sadovnikov, Dmitry V Zinchenko, Valery M Lipkin, Vladimir P Zav'yalov
We have prepared (125)I-labeled cholera toxin B subunit ((125)I-labeled CT-B, a specific activity of 98Ci/mmol) and found that its binding to T and B lymphocytes from the blood of healthy donors was high-affinity (Kd 2.8 and 3.0nM, respectively). The binding of labeled protein was completely inhibited by unlabeled thymosin-α1 (TM-α1), interferon-α2 (IFN-α2), and the synthetic peptide LKEKK that corresponds to residues 16-20 in TM-α1 and 131-135 in IFN-α2, but was not inhibited by the synthetic peptide KKEKL with inverted amino acid sequence (Ki>10μM)...
July 15, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28700350/thymosin-%C3%AE-4-inhibits-proliferation-and-induces-apoptosis-of-hepatic-stellate-cells-through-pi3k-akt-pathway
#14
Lili Zhu, Mingliang Cheng, Yongmei Liu, Yumei Yao, Zixin Zhu, Baofang Zhang, Qiuju Mou, Yiju Cheng
Liver fibrosis is a necessary stage for chronic liver diseases, and serious threat to human health. Hepatic fibrosis is a necessary stage for chronic liver diseases. Hepatic stellate cells (HSCs) are the primary cell type responsible for fibrosis. Thymosin beta 4 (Tβ4) has a potential role in the pathogenesis of liver fibrosis and that it is especially associated with the activation of HSCs, however, the underlying mechanisms are not fully elucidated. Herein, we investigated the potential role of Tβ4 in liver fibrosis by describing the effects of Tβ4, and we discuss the possible signaling pathway regulated by Tβ4...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28693071/-effect-of-transcatheter-arterial-chemoembolization-combined-with-thymosin-alpha-1-on-the-autophagy-of-immune-cells-from-advanced-hepatocellular-carcinoma
#15
S J Fang, L Y Zheng, Z W Zhao, X X Fan, M Xu, J S Ji
Objective: To investigate the effect of transcatheter arterial chemoembolization(TACE)combined with thymosin alpha1(Tα1)on the autophagy of immune cells from advanced hepatocellular carcinoma. Methods: A total of 30 patients with advanced liver cancer enrolled in Lishui Central Hospital from September 2015 to June 2016 were collected in this study. The average age of patients was 16-75(56±12) years. All patients were treated with TACE after enrolled in hospital in a week. Patients were divided into TACE group and TACE+ Tα1 treatment group(15 cases in each group)...
July 4, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28657437/neuropeptide-imaging-in-rat-spinal-cord-with-maldi-tof-ms-method-development-for-the-application-in-pain-related-disease-studies
#16
Ping Sui, Hiroyuki Watanabe, Konstantin Artemenko, Wei Sun, Georgy Bakalkin, Malin Andersson, Jonas Bergquist
Spinal cord as a connection between brain and peripheral nervous system is an essential material for studying neural transmission, especially in pain-related research. This study was the first to investigate pain-related neuropeptide distribution in rat spinal cord using a matrix-assisted laser desorption ionization-time of flight imaging mass spectrometry (MALDI TOF MS) approach. The imaging workflow was evaluated and showed that MALDI TOF MS provides efficient resolution and robustness for neuropeptide imaging in rat spinal cord tissue...
June 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/28630423/thymosin-beta-4-regulates-activation-of-hepatic-stellate-cells-via-hedgehog-signaling
#17
Jieun Kim, Jeongeun Hyun, Sihyung Wang, Chanbin Lee, Jae-Wook Lee, Eun-Yi Moon, Heejae Cha, Anna Mae Diehl, Youngmi Jung
The molecular mechanisms of thymosin beta-4 (TB4) involved in regulating hepatic stellate cell (HSC) functions remain unclear. Therefore, we hypothesize that TB4 influences HSC activation through hedgehog (Hh) pathway. HSC functions declined in a TB4 siRNA-treated LX-2. TB4 suppression down-regulated both integrin linked kinase (ILK), an activator of smoothened, and phosphorylated glycogen synthase kinase 3 beta (pGSK-3B), an inactive form of GSK-3B degrading glioblastoma 2 (GLI2), followed by the decreased expression of both smoothened and GLI2...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28611096/thymosin-beta-4-is-elevated-in-women-with-heart-failure-with-preserved-ejection-fraction
#18
Chester L Drum, Warren K Y Tan, Siew-Pang Chan, Leroy S Pakkiri, Jenny P C Chong, Oi-Wah Liew, Tze-Pin Ng, Lieng-Hsi Ling, David Sim, Kui-Toh G Leong, Daniel P S Yeo, Hean-Yee Ong, Fazlur Jaufeerally, Raymond C C Wong, Ping Chai, Adrian F Low, Pia Davidsson, Mathias Liljeblad, Ann-Sofi Söderling, Li-Ming Gan, Ratan V Bhat, Kristy Purnamawati, Carolyn S P Lam, A Mark Richards
BACKGROUND: Thymosin beta-4 (TB4) is an X-linked gene product with cardioprotective properties. Little is known about plasma concentration of TB4 in heart failure (HF), and its relationship with other cardiovascular biomarkers. We sought to evaluate circulating TB4 in HF patients with preserved (HFpEF) or reduced (HFrEF) ejection fraction compared to non-HF controls. METHODS AND RESULTS: TB4 was measured using a liquid chromatography and mass spectrometry assay in age- and sex-matched HFpEF (n=219), HFrEF (n=219) patients, and controls (n=219) from a prospective nationwide study...
June 13, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28602595/topical-treatment-of-corneal-alkali-burns-with-gly-thymosin-%C3%AE-4-solutions-and-in-situ-hydrogels-via-inhibiting-corneal-neovascularization-and-improving-corneal-epidermal-recovery-in-experimental-rabbits
#19
Weili Zhang, Liya Nie, Lina Du, Wenyang Chen, Zhihong Wu, Yiguang Jin
AIM: Corneal alkali burns are a severe disease and commonly encountered in the emergent clinic. A rapid medical treatment for the burn is very important. Gly-thymosin β4 (Gly-Tβ4) is a biomimic derivative of natural thymosin β4. The aim of this study is to evaluate the corneal recovery effects of Gly-Tβ4 topical therapy on alkali burns in rabbit corneas. METHODS: Rabbit alkali burns were induced with NaOH-contained filter paper. Phosphate-buffered solutions at pH 7...
June 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28559563/cystic-fibrosis-thymosin-%C3%AE-1-rescues-cftr-activity
#20
Sarah Crunkhorn
No abstract text is available yet for this article.
May 31, 2017: Nature Reviews. Drug Discovery
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