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https://www.readbyqxmd.com/read/28823115/identification-of-distinctive-clinical-significance-in-hospitalized-patients-with-endoscopic-duodenal-mucosal-lesions
#1
Yeji Han, Hye-Kyung Jung, Ji Young Chang, Chang Mo Moon, Seong-Eun Kim, Ki-Nam Shim, Sung-Ae Jung, Joo-Young Kim, Ji-Yun Bae, Sae-In Kim, Ji-Hyun Lee, Sanghui Park
Background/Aims: Duodenitis is not infrequent finding in patient undergoing endoscopy. However, hospitalized patients have a higher incidence of secondary duodenal mucosal lesions that might be related with inflammatory bowel disease (IBD), cytomegalovirus (CMV) infection, tuberculosis, immunologic disorders, or other rare infections. We aimed to identify clinicopathologic features of duodenal mucosal lesions in hospitalized patients. Methods: All hospitalized patients having duodenal mucosal lesions were identified by endoscopic registration data and pathologic data query from 2011 to 2014...
August 21, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28822998/spontaneous-shrinkage-of-solitary-osteochondromas
#2
Hisaki Aiba, Satoshi Yamada, Norio Yamamoto, Katsuhiro Hayashi, Shinji Miwa, Hiroyuki Tsuchiya, Takanobu Otsuka
OBJECTIVE: Osteochondromas are the most common benign bone tumors, and thus far, their spontaneous shrinkage is considered a rare phenomenon. This study was designed to investigate the exact ratio of remission to progressive or stable cases and analyze the mechanism of tumor regression on the basis of existing theories. MATERIALS AND METHODS: We retrospectively collected images of solitary osteochondromas in patients from 1992 to 2013, excluding cases involving short-term follow-up periods and follow-up periods that ended before growth plate closure...
August 19, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28822920/are-frailty-components-associated-with-disability-in-specific-activities-of-daily-living-in-community-dwelling-older-adults-a-multicenter-canadian-study
#3
Véronique Provencher, François Béland, Louise Demers, Johanne Desrosiers, Nathalie Bier, José Alberto Ávila-Funes, Claude Galand, Dominic Julien, John D Fletcher, Lise Trottier, Benyahia Hami
Current studies show the relevance of geriatric prevention and rehabilitation programs to slow down the development of disability in community-dwelling older adults who are becoming frail. This evidence reveals the importance of improving knowledge on how individual components of frailty and specific disability in basic and instrumental activities of daily living (ADL) are related, to offer early, targeted, and tailored interventions. The objective was to examine the association between each of the five frailty phenotype components (weakness, slowness, exhaustion, low physical activity, weight loss) and disability in specific ADL pertaining to physical aspects (bathing, dressing, cutting toe nails, transportation, shopping, housekeeping, food purchasing, food preparation) and cognitive aspects (finances, telephone, medication)...
August 2, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28822828/targeted-lowering-of-central-blood-pressure-in-patients-with-hypertension-baseline-recruitment-rationale-and-design-of-a-randomized-controlled-trial-the-low-cbp-study
#4
James E Sharman, Tony Stanton, Christopher M Reid, Anthony Keech, Philip Roberts-Thomson, Simon Stewart, Robert Greenough, Michael Stowasser, Walter P Abhayaratna
BACKGROUND: High blood pressure (BP) is the most common modifiable cause of death from cardiovascular disease. Lowering BP with medication improves patient outcomes, but even in populations with normal upper arm (brachial) BP there remains considerable residual risk for cardiovascular disease and this may be due to persistently elevated central BP. There has never been a trial to determine the value of targeted central BP lowering among patients with hypertension, and this was the aim of this study...
August 16, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28822812/determinants-of-thermostability-in-the-cytochrome-p450-fold
#5
REVIEW
Kurt L Harris, Raine E S Thomson, Silja J Strohmaier, Yosephine Gumulya, Elizabeth M J Gillam
Cytochromes P450 are found throughout the biosphere in a wide range of environments, serving a multitude of physiological functions. The ubiquity of the P450 fold suggests that it has been co-opted by evolution many times, and likely presents a useful compromise between structural stability and conformational flexibility. The diversity of substrates metabolized and reactions catalyzed by P450s makes them attractive starting materials for use as biocatalysts of commercially useful reactions. However, process conditions impose different requirements on enzymes to those in which they have evolved naturally...
August 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28822756/differences-in-psychosocial-and-behavioral-variables-by-dietary-screening-tool-risk-category-in-older-adults
#6
Geoffrey W Greene, Ingrid Lofgren, Chelsea Paulin, Mary L Greaney, Phillip G Clark
BACKGROUND: The Dietary Screening Tool (DST) has been validated as a dietary screening instrument for older adults defining three categories of potential nutritional risk based on DST score cutoffs. Previous research has found that older adults classified as being "at risk" differed from those categorized as being "not at risk" for a limited number of health-related variables. The relationship between risk categories and a wide variety of variables has not yet been explored. This research will contribute to an increased understanding of clustering of multiple health concerns in this population...
August 17, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28822755/does-the-transformation-of-dietitians-from-counseling-to-therapy-also-apply-to-the-physical-and-therapeutic-environment-a-case-study-of-israeli-practice
#7
Anat Gesser-Edelsburg, Yael Birman
BACKGROUND: Lifestyle change can be influenced through effective interaction between care receiver and care provider. The physical environment where the interaction occurs can affect the dynamics of long-term therapeutic treatment. There have been no studies on the perception of the physical environment in nutritional treatment. OBJECTIVE: Our aim was to ascertain the impact of the physical environment on the dynamics and communication between dietitian and patient based on perceptions of dietitians...
August 17, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28822709/the-influence-of-antidepressants-on-restless-legs-syndrome-and-periodic-limb-movements-a-systematic-review
#8
REVIEW
Bhanu Prakash Kolla, Meghna P Mansukhani, J Michael Bostwick
Restless legs syndrome is commonly co-morbid with medical conditions that are treated with antidepressant medications, such as depression, anxiety, fibromyalgia, and chronic insomnia disorder. Evidence from case reports and cross-sectional studies suggests that antidepressants may induce or worsen restless legs syndrome and increase periodic limb movements. We undertook a systematic review of the literature to identify and collate all prospective studies that measured restless legs syndrome symptoms and/or periodic limb movements following the introduction of an antidepressant...
June 15, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28822690/microrna29a-treatment-improves-early-tendon-injury
#9
Ashlee E Watts, Neal L Millar, Josh Platt, Susan M Kitson, Moeed Akbar, Raquel Rech, Jay Griffin, Roy Pool, Tom Hughes, Iain B McInnes, Derek S Gilchrist
Tendon injuries (tendinopathies) are common in human and equine athletes and characterized by dysregulated collagen matrix, resulting in tendon damage. We have previously demonstrated a functional role for microRNA29a (miR29a) as a post-transcriptional regulator of collagen 3 expression in murine and human tendon injury. Given the translational potential, we designed a randomized, blinded trial to evaluate the potential of a miR29a replacement therapy as a therapeutic option to treat tendinopathy in an equine model that closely mimics human disease...
July 28, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28822683/hsp90-sensitivity-to-adp-reveals-hidden-regulation-mechanisms
#10
Jackson C Halpin, Timothy O Street
The ATPase cycle of the Hsp90 molecular chaperone is essential for maintaining the stability of numerous client proteins. Extensive analysis has focused on ATP-driven conformational changes of Hsp90, however, little is known about how Hsp90 operates under physiological nucleotide conditions in which both ATP and ADP are present. By quantifying Hsp90 activity under mixed nucleotide conditions we find dramatic differences in ADP-sensitivity among Hsp90 homologs. ADP acts as a strong ATPase inhibitor of cytosol-specific Hsp90 homologs, whereas organellular Hsp90 homologs (Grp94 and TRAP1) are relatively insensitive to the presence of ADP...
August 16, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28822674/increasing-parental-knowledge-related-to-the-human-papillomavirus-hpv-vaccine
#11
Joseph J Cipriano, Robert Scoloveno, Angela Kelly
INTRODUCTION: The purposes of this study were to evaluate parental attitudes toward general vaccination protocols and increase parental knowledge of the human papilloma virus (HPV) vaccine. METHODS: A nonprobability convenience sample (N = 75) using a pre-/postintervention study design was conducted in a pediatric office in southern New Jersey. The Parental Attitudes Module measured the general disposition toward having children receive any type of vaccine. The HPV Knowledge Survey was a second tool used to specifically measures knowledge of the HPV vaccine...
August 16, 2017: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/28822667/doppler-parameters-derived-from-transthoracic-echocardiography-accurately-detect-bioprosthetic-mitral-valve-dysfunction
#12
Ryan J Spencer, Ken G Gin, Michael Y C Tsang, Teresa S M Tsang, Parvathy Nair, Pui K Lee, John Jue
BACKGROUND: Detecting bioprosthetic mitral valve dysfunction on transthoracic echocardiography can be challenging because of acoustic shadowing of regurgitant jets and a wide normal range of transvalvular gradients. Several studies in mechanical mitral valves have demonstrated the utility of the transthoracically derived parameters E (peak early mitral inflow velocity), pressure half-time, and the ratio of mitral inflow velocity-time integral (VTIMV) to left ventricular outflow tract velocity-time integral (VTILVOT) in detecting significant prosthetic dysfunction...
August 16, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28822654/polarity-independent-effects-of-tdcs-on-paired-associative-stimulation-induced-plasticity
#13
Hanna Faber, Alexander Opitz, Florian Müller-Dahlhaus, Ulf Ziemann
BACKGROUND: Transcranial direct current stimulation (tDCS) can polarize the cortex of the human brain. OBJECTIVE/HYPOTHESIS: We sought to verify the hypothesis that posterior-anterior (PA) but not anterior-posterior (AP) tDCS of primary motor cortex (M1) produces cooperative effects with corticospinal plasticity induced by paired associative stimulation of the supplementary motor area (SMA) to M1 projection (PASSMA→M1) in a highly controlled experimental design...
July 27, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28822637/porcine-dermis-patch-augmentation-of-supraspinatus-tendon-repairs-a-pilot-study-assessing-tendon-integrity-and-shoulder-function-2%C3%A2-years-after-arthroscopic-repair-in-patients-aged-60%C3%A2-years-or%C3%A2-older
#14
Matthias Flury, Dominik Rickenbacher, Christian Jung, Marco M Schneider, David Endell, Laurent Audigé
PURPOSE: To investigate the 2-year postoperative clinical and subjective outcomes after arthroscopic rotator cuff repair (ARCR) with xenologous porcine dermal patch augmentation compared with ARCR alone. METHODS: Patients aged 60 years or older with a complete supraspinatus (SSP) tendon tear underwent primary ARCR with a transosseous-equivalent technique. By use of a matched-pair comparative trial design, a consecutive series of 20 patients receiving additional xenologous porcine dermal patch augmentation (patch group) was matched by tear location with 20 patients who received ARCR only (control group)...
August 16, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28822574/analysis-of-individual-and-total-microcystins-in-surface-water-by-on-line-preconcentration-and-desalting-coupled-to-liquid-chromatography-tandem-mass-spectrometry
#15
Gabriel Munoz, Sung Vo Duy, Audrey Roy-Lachapelle, Barry Husk, Sébastien Sauvé
A fast and high-throughput method is proposed for the determination of total microcystins (ΣMC) in environmental surface waters. After a 1-h Lemieux-von Rudloff oxidation step to yield the 2-methyl-3-methoxy-4-phenylbutyric acid (MMPB) moiety, samples were quenched, filtered, and directly analyzed. This was achieved via solid phase extraction (SPE) coupled on-line to ultra-high performance liquid chromatography electrospray ionization triple stage quadrupole mass spectrometry. The choice of on-line SPE settings was conducted using experimental designs...
August 5, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28822549/effect-of-substituting-soybean-meal-and-canola-cake-with-grain-based-dried-distillers-grains-with-solubles-as-a-protein-source-on-feed-intake-milk-production-and-milk-quality-in-dairy-cows
#16
C Gaillard, M T Sørensen, M Vestergaard, M R Weisbjerg, A Basar, M K Larsen, H Martinussen, U Kidmose, J Sehested
The growth of the bioethanol industry is leading to an increase in the production of coproducts such as dried distillers grains with solubles (DDGS). Both corn-based DDGS and grain-based DDGS (gDDGS; defined as originating from grain sources such as barley, wheat, triticale, or a mix, excluding corn) appear to be relevant sources of feed and protein for dairy cows. To date, most of the studies investigating DDGS have been performed with corn-based DDGS. The objectives of this study were to determine the effects of the proportion of gDDGS in the diet on feed intake, milk production, and milk quality...
August 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28822545/effects-of-the-dose-and-viability-of-saccharomyces-cerevisiae-2-ruminal-fermentation-performance-of-lactating-dairy-cows-and-correlations-between-ruminal-bacteria-abundance-and-performance-measures
#17
Y Jiang, I M Ogunade, K G Arriola, M Qi, D Vyas, C R Staples, A T Adesogan
This study examined effects of the dose and viability of supplemented Saccharomyces cerevisiae yeast strain YE1496 on ruminal fermentation and performance of lactating dairy cows. A second objective was to examine correlations between ruminal bacteria abundance and performance measures. Four ruminally cannulated lactating cows (284 ± 18 days in milk) were assigned randomly to 1 of 4 treatment sequences in a 4 × 4 Latin square experimental design using four 21-d experimental periods. Cows were fed a nonacidotic total mixed ration comprising 22...
August 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28822544/performance-strategies-affect-mammary-gland-development-in-prepubertal-heifers
#18
R L Albino, A L Sguizzato, K M Daniels, M S Duarte, M M Lopes, S E F Guimarães, M M D C A Weller, M I Marcondes
In Brazil, the majority of dairy cattle are Holstein × Gyr (H×G). It is unknown whether excessive energy intake negatively affects their mammary development to the same extent as in purebred Holsteins. We hypothesized that mammary development of H×G heifers can be affected by dietary energy supply. We evaluated the effect of different average daily gains (ADG) achieved by feeding different amounts of a standard diet during the growing period on biometric measurements, development of mammary parenchyma (PAR) and mammary fat pad (MFP), and blood hormones...
August 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28822519/high-sensitive-c-reactive-protein-and-interleukin-6-in-atrial-fibrillation-with-rheumatic-mitral-stenosis-from-indian-cohort
#19
Gautam Sharma, Sudhir Shetkar, Ashu Bhasin, Lakshmy Ramakrishnan, Rajnish Juneja, Nitish Naik, Ambuj Roy, Sivasubramanian Ramakrishnan, Balram Bhargava, Vinay Kumar Bahl
INTRODUCTION: Presence of chronic low grade inflammation has often been implicated in the etiology of atrial fibrillation (AF). Whether pre-existing inflammatory state promotes AF or initiation of AF activates inflammation is a dilemma among clinicians. This study investigates the role of high sensitive C reactive protein (hs-CRP) and interleukin 6 (IL-6) in AF with rheumatic mitral stenosis (Rh-MS) as markers of chronic inflammation. METHODS: This case control cohort included sixty five (n=65) Rh-MS patients having other valve lesions as trivial to mild...
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28822464/using-simulation-to-assess-the-impact-of-triage-interruptions
#20
Kimberly D Johnson, Abeer Alhaj-Ali
INTRODUCTION: Interruptions are common in the emergency department and contribute to catastrophic errors. Care priorities and acuity levels are assigned during triage, meaning that mistakes and omissions during the triage process could have detrimental effects on patients. The purpose of this project was to assess the feasibility of investigating the impact of interruptions on triage and the decision-making process in a simulated setting. METHODS: A 2-phase, sequential exploratory mixed method design was used...
September 2017: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
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