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https://www.readbyqxmd.com/read/29677705/in-house-validation-and-small-scale-collaborative-study-to-evaluate-analytical-performances-of-multi-mycotoxin-screening-methods-based-on-liquid-chromatography-high-resolution-mass-spectrometry-case-study-fusarium-toxins-in-wheat
#1
Biancamaria Ciasca, Michelangelo Pascale, Valerio Guido Altieri, Francesco Longobardi, Michele Suman, Dante Catellani, Veronica M T Lattanzio
A strong trend toward using highly selective mass spectrometry technologies for screening of multiple mycotoxins has been observed in recent years. In the present study, the process of validation of a multi-mycotoxin screening method based on liquid chromatography high-resolution mass spectrometry method is presented. The method was intended for the simultaneous screening of the major Fusarium toxins (deoxynivalenol, 3- and 15-acetyl deoxynivalenol, T-2 and HT-2 toxins, zearalenone, enniatins A, A1, B, B1, beauvericin) in wheat...
April 20, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29677663/haptic-based-perception-empathy-biofeedback-system-for-balance-rehabilitation-in-patients-with-chronic-stroke-concepts-and-initial-feasibility-study
#2
Kazuhiro Yasuda, Kenta Saichi, Naomi Kaibuki, Hiroaki Harashima, Hiroyasu Iwata
BACKGROUND: Most individuals have sensory disturbances post stroke, and these deficits contribute to post-stroke balance impairment. The haptic-based biofeedback (BF) system appears to be one of the promising tools for balance rehabilitation in patients with stroke, and the BF system can increase the objectivity of feedback and encouragement than that provided by a therapist. RESEARCH QUESTION: Studies in skill science indicated that feedback or encouragement from a coach or trainer enhances motor learning effect...
April 14, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29677647/arsenic-effects-on-some-photophysical-parameters-of-cichorium-intybus-under-different-radiation-and-water-irrigation-regimes
#3
Gabriela Cordon, Analia Iriel, Alicia Fernández Cirelli, M Gabriela Lagorio
The presence of arsenic (As) in groundwater is a major problem in several parts of Latin America. In the present work, non-destructive approaches to monitor the effects of As on plants of Cichorium intybus, an herbaceous Asteraceae, were explored. In this sense, the effects of As at different levels of water and radiation were evaluated on these crops. Plants were grown in a greenhouse, watered daily with As solutions and exposed to different water and/or light conditions for four months, using a three-factor (As, water, radiation) and two-level resource (As vs non As, field capacity vs half-field capacity condition, light vs shade condition) factorial design...
April 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29677604/the-association-between-unemployment-and-depression-results-from-the-population-based-life-adult-study
#4
Andrea E Zuelke, Tobias Luck, Matthias L Schroeter, A Veronica Witte, Andreas Hinz, Christoph Engel, Cornelia Enzenbach, Silke Zachariae, Markus Loeffler, Joachim Thiery, Arno Villringer, Steffi G Riedel-Heller
BACKGROUND: Unemployment is a risk factor for impaired mental health. Based on a large population-based sample, in this study we therefore sought to provide detailed information on the association between unemployment and depression including information on (i) differences between men and women, (ii) differences between different types of unemployment, and (iii) on the impact of material and social resources on the association. METHODS: We studied 4,842 participants (18-65 years) of the population-based LIFE-Adult-Study...
April 10, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29677597/the-systematic-evaluation-of-size-dependent-toxicity-and-multi-time-biodistribution-of-gold-nanoparticles
#5
Xiaomin Li, Zhenpeng Hu, Jinlong Ma, Xinyu Wang, Yapei Zhang, Wei Wang, Zhi Yuan
As a promising nanomaterial, gold nanoparticles (Au NPs) have been widely applied in diagnosis, drug and gene delivery, and photothermal therapy. However, the toxicity and biodistribution profile of differently sized Au NPs still remains controversial and incomplete, thus hindering their further applications. Herein, a systematic evaluation of size effect on toxicity and multi-time (from 4 h to 90 days) biodistribution of Au NPs ranging from 6.2 nm to 61.2 nm was conducted. The in vitro toxicity by MTT assays manifested that toxicity could be distinctly observed and increased with size decreasing when the dose of Au NPs reached up to a certain amount (1 mM)...
April 4, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29677553/developmental-change-in-tone-perception-in-mandarin-monolingual-english-monolingual-and-mandarin-english-bilingual-infants-divergences-between-monolingual-and-bilingual-learners
#6
Leher Singh, Charlene S L Fu, Xian Hui Seet, Ashley P Y Tong, Joelle L Wang, Catherine T Best
Most languages use lexical tone to discriminate the meanings of words. There has been recent interest in tracking the development of tone categories during infancy. These studies have focused largely on monolingual infants learning either a tone language or a non-tone language. It remains to be seen how bilingual infants learning one tone language (e.g., Mandarin) and one non-tone language (e.g., English) discriminate tones. Here, we examined infants' discrimination of two Mandarin tones pairs: one salient and one subtle...
April 17, 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29677550/impacts-of-transportation-sector-emissions-on-future-u-s-air-quality-in-a-changing-climate-part-i-projected-emissions-simulation-design-and-model-evaluation
#7
Patrick Campbell, Yang Zhang, Fang Yan, Zifeng Lu, David Streets
Emissions from the transportation sector are rapidly changing worldwide; however, the interplay of such emission changes in the face of climate change are not as well understood. This two-part study examines the impact of projected emissions from the U.S. transportation sector (Part I) on ambient air quality in the face of climate change (Part II). In Part I of this study, we describe the methodology and results of a novel Technology Driver Model (see graphical abstract) that includes 1) transportation emission projections (including on-road vehicles, non-road engines, aircraft, rail, and ship) derived from a dynamic technology model that accounts for various technology and policy options under an IPCC emission scenario, and 2) the configuration/evaluation of a dynamically downscaled Weather Research and Forecasting/Community Multiscale Air Quality modeling system...
April 17, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29677541/tert-butyl-4-1-phenyl-1h-pyrazol-4-yl-methyl-piperazine-1-carboxylate-lqfm104-new-piperazine-derivative-with-antianxiety-and-antidepressant-like-effects-putative-role-of-serotonergic-system
#8
Dayane Moreira da Silva, Germán Sanz, Boniek Gontijo Vaz, Flávio Silva de Carvalho, Luciano Morais Lião, Danillo Ramos de Oliveira, Lorrane Kelle da Silva Moreira, Carina Sofia Cardoso, Adriane Ferreira de Brito, Daiany Priscilla Bueno da Silva, Fabio Fagundes da Rocha, Ianca Gontijo Cavalcante Santana, Pablinny Moreira Galdino, Elson Alves Costa, Ricardo Menegatti
The piperazine derivatives correspond to an extensive chemical class of compounds with numerous neuropharmacological activities, including antidepressant (e.g., nefazodone, trazodone) and anxiolytic (e.g., buspirone) properties. Therefore, aiming to identify a new antidepressant and antianxiety lead-compound, our group designed, synthesized, and investigated the effects of a new piperazine compound, namely, LQFM104, on the behavior of mice. Male albino Swiss mice were treated with LQFM104 prior to predictive behavioral tests as open field (OFT), elevated plus maze (EPM), forced swimming (FST), and tail suspension tests (TST)...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677494/automated-structure-and-sequence-based-design-of-proteins-for-high-bacterial-expression-and-stability
#9
Adi Goldenzweig, Moshe Goldsmith, Shannon E Hill, Or Gertman, Paola Laurino, Yacov Ashani, Orly Dym, Tamar Unger, Shira Albeck, Jaime Prilusky, Raquel L Lieberman, Amir Aharoni, Israel Silman, Joel L Sussman, Dan S Tawfik, Sarel J Fleishman
No abstract text is available yet for this article.
April 19, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29677412/gunderkids-design-of-a-clinical-care-management-program-for-parents-with-substance-abuse-and-their-newborn-children-with-a-focus-on-preventing-child-abuse
#10
Ann E Budzak-Garza, Allison L Allmon Dixson, Renee A Holzer, Kaitlin E Lillard-Pierce, Carolynn J Devine
BACKGROUND: In response to an increased need to care for babies born to mothers with substance abuse issues, we developed GunderKids, a care management program that provides integrated medical care beyond standard-of-care, well-child appointments for these socially complex families. METHODS: The program incorporates frequent visits to the pediatrician and the care team, which includes pediatric nurses, a pediatric social worker, and a child psychologist. Enrollment is voluntary...
March 2018: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29677404/hybrid-scaffolds-of-mg-alloy-mesh-reinforced-polymer-extracellular-matrix-composite-for-critical-sized-calvarial-defect-reconstruction
#11
Yingqi Chen, Sang-Ho Ye, Hideyoshi Sato, Yang Zhu, Vesselin Shanov, Tarannum Tiasha, Antonio D'Amore, Samuel Luketich, Guojiang Wan, William R Wagner
The challenge of developing scaffolds to reconstruct critical-sized calvarial defects without the addition of high levels of exogenous growth factor remains relevant. Both osteogenic regenerative efficacy as well as suitable mechanical properties for the temporary scaffold system are of importance. In this study, a Mg alloy mesh reinforced polymer/demineralized bone matrix (DBM) hybrid scaffold was designed where the hybrid scaffold was fabricated by a concurrent electrospinning/electrospraying of poly(lactic-co-glycolic) (PLGA) polymer and DBM suspended in hyaluronic acid (HA)...
April 20, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29677398/does-stress-increase-risk-of-breast-cancer-a-15-year-prospective-study
#12
Phyllis Butow, Melanie Price, Joseph Coll, Katherine Tucker, Bettina Meiser, Roger Milne, Judith Wilson, Louise Heiniger, Brandi Baylock, Tracey Bullen, Prue Weideman, Kelly-Anne Phillips
OBJECTIVE: The possible impact of stress on cancer incidence remains controversial. We prospectively evaluated associations between life event stressors, social support, personality characteristics (optimism, anger control, anti-emotionality) and risk of developing primary breast cancer (BCa), in women at increased familial risk of BCa. METHODS: A prospective cohort, repeated measures design was employed. Recruitment was through the Kathleen Cuningham Foundation Consortium for Research into Familial breast cancer (kConFab), which collects genetic, epidemiological and clinical data from Australasian families with multiple BCa cases...
April 20, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29677334/monocular-microsaccades-do-they-really-occur
#13
Yu Fang, Christopher Gill, Martina Poletti, Michele Rucci
Small saccades, known as microsaccades, occur frequently during fixation. Several recent studies have argued that a considerable fraction of these movements are present in the traces from one eye only. This claim contrasts with the findings of older reports, which concluded that microsaccades, like larger saccades, are virtually always binocular events. Here we examined the characteristics of small saccades by means of two of the most established high-resolution eye-tracking techniques available. A binocular Dual Purkinje Image eye-tracker was used to record eye movements while observers fixated, with their head immobilized, on markers displayed on a monitor...
March 1, 2018: Journal of Vision
https://www.readbyqxmd.com/read/29677326/the-visual-perception-of-metal
#14
James T Todd, J Farley Norman
The present research was designed to examine how the presence or absence of ambient light influences the appearance of metal. The stimuli depicted three possible objects that were illuminated by three possible patterns of illumination. These were generated by a single point light source, two rectangular area lights, or projecting light onto a translucent white box that contained the object (and the camera) so that the object would be illuminated by ambient light in all directions. The materials were simulated using measured parameters of chrome with four different levels of roughness...
March 1, 2018: Journal of Vision
https://www.readbyqxmd.com/read/29677280/assessment-of-the-effectiveness-of-combat-eyewear-protection-against-blast-overpressure
#15
A Sundaramurthy, M Skotak, E Alay, G Unnikrishnan, H Mao, X Duan, S T Williams, T H Harding, N Chandra, J Reifman
It is unclear whether combat eyewear used by U. S. Service members is protective against blast overpressures (BOPs) caused by explosive devices. Here, we investigated the mechanisms by which BOP bypasses eyewear and increases eye surface pressure. We performed experiments and developed three-dimensional (3D) finite element (FE) models of a head form (HF) equipped with an advanced combat helmet (ACH) and with no eyewear, spectacles, or goggles in a shock tube at three BOPs and five head orientations relative to the blast wave...
July 1, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29677210/provider-reported-barriers-and-solutions-to-improve-testing-among-tuberculosis-patients-eligible-for-drug-susceptibility-test-a-qualitative-study-from-programmatic-setting-in-india
#16
Hemant Deepak Shewade, Arun M Kokane, Akash Ranjan Singh, Malik Parmar, Manoj Verma, Prabha Desikan, Sheeba Naz Khan, Ajay M V Kumar
BACKGROUND: In a study conducted in Bhopal district (a setting with facility for molecular drug susceptibility testing (DST)) located in central India in 2014-15, we found high levels of pre-diagnosis attrition among patients with presumptive multi drug-resistant tuberculosis (MDR-TB)-meaning TB patients who were eligible for DST, were not being tested. OBJECTIVES: In this study, we explored the health care provider perspectives into barriers and suggested solutions for improving DST...
2018: PloS One
https://www.readbyqxmd.com/read/29677181/exploiting-glycan-topography-for-computational-design-of-env-glycoprotein-antigenicity
#17
Wen-Han Yu, Peng Zhao, Monia Draghi, Claudia Arevalo, Christina B Karsten, Todd J Suscovich, Bronwyn Gunn, Hendrik Streeck, Abraham L Brass, Michael Tiemeyer, Michael Seaman, John R Mascola, Lance Wells, Douglas A Lauffenburger, Galit Alter
Mounting evidence suggests that glycans, rather than merely serving as a "shield", contribute critically to antigenicity of the HIV envelope (Env) glycoprotein, representing critical antigenic determinants for many broadly neutralizing antibodies (bNAbs). While many studies have focused on defining the role of individual glycans or groups of proximal glycans in bNAb binding, little is known about the effects of changes in the overall glycan landscape in modulating antibody access and Env antigenicity...
April 20, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29677046/student-and-preceptor-advancement-in-a-dedicated-education-site-innovation-in-clinical-education-for-advanced-practice-nurses
#18
Katherine C Hall, Sandy K Diffenderfer, April Stidham, Christine M Mullins
In the 1990s, dedicated education units transformed undergraduate preceptorships, but graduate preceptorships remain static. The dyadic nurse practitioner preceptorship model supports an environment where faculty, students, and preceptors may overlook nuances that affect the teaching-learning process. This article describes an innovative clinical education model, Student and Preceptor Advancement in a Dedicated Education Site, designed to improve preceptorships for advanced practice nurses. The focus is on adaptations made to facilitate use in advanced practice nursing programs...
April 19, 2018: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29677045/anxiety-of-active-and-passive-role-groups-in-clinical-simulation-a-pilot-study
#19
Tedra S Smith, Connie Hogewood, Sherita Etheridge, Sylvia Britt, David E Vance
Clinical simulation within nursing programs is a hallmark teaching strategy. With faculty challenged to design effective simulations for large groups of students, students are often divided into an active or passive role group. This study examined the anxiety levels experienced by students in the two roles. Results indicated that trait anxiety was similar in both groups before and after the simulation; however, there was a significant decrease in state anxiety ratings in the active role group following the simulation...
April 19, 2018: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29677020/clinical-experience-in-minimally-invasive-cardiac-surgery-with-virtually-wall-less-venous-cannulas
#20
Enrico Ferrari, Ludwig K von Segesser, Denis Berdajs, Ludwig Müller, Maximilian Halbe, Francesco Maisano
OBJECTIVE: Inadequate peripheral venous drainage during minimally invasive cardiac surgery (MICS) is a challenge and cannot always be solved with increased vacuum or increased centrifugal pump speed. The present study was designed to assess the benefit of virtually wall-less transfemoral venous cannulas during MICS. METHODS: Transfemoral venous cannulation with virtually wall-less cannulas (3/8″ 24F 530-630-mm ST) was performed in 10 consecutive patients (59 ± 10 years, 8 males, 2 females) undergoing MICS for mitral (6), aortic (3), and other (4) procedures (combinations possible)...
April 19, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
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