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https://www.readbyqxmd.com/read/29909603/urinary-outcomes-in-patients-with-down-s-syndrome-and-hirschsprung-s-disease
#1
Alexander Johannes Martinus Dingemans, Carlos Albert Reck-Burneo, Molly Fuchs, Alejandra Vilanova Sanchez, Victoria Alison Lane, Erin Hoover, Tassiana Maloof, Laura Weaver, Marc A Levitt, Richard J Wood
INTRODUCTION:  Previous research in children with Hirschsprung's disease (HD) and Down's syndrome (DS) has focused on colorectal outcomes. We set out to review urinary outcomes in this patient group. METHODS:  The medical records of all patients aged five years and older with HD were reviewed, and patients and caregivers filled out the Vancouver Symptom Score at intake, which is designed and validated to diagnose dysfunctional elimination syndrome. RESULTS:  A total of 104 patients with HD were included in this study...
June 17, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29909528/accuracy-of-computer-aided-design-models-of-the-jaws-produced-using-ultra-low-mdct-doses-and-asir-and-mbir
#2
Asma'a A Al-Ekrish, Sara A Alfadda, Wadea Ameen, Romed Hörmann, Wolfgang Puelacher, Gerlig Widmann
PURPOSE: To compare the surface of computer-aided design (CAD) models of the maxilla produced using ultra-low MDCT doses combined with filtered backprojection (FBP), adaptive statistical iterative reconstruction (ASIR) and model-based iterative reconstruction (MBIR) reconstruction techniques with that produced from a standard dose/FBP protocol. METHODS: A cadaveric completely edentulous maxilla was imaged using a standard dose protocol (CTDIvol: 29.4 mGy) and FBP, in addition to 5 low dose test protocols (LD1-5) (CTDIvol: 4...
June 16, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29909494/the-efficacy-and-safety-of-knotless-barbed-sutures-in-total-joint-arthroplasty-a-meta-analysis-of-randomized-controlled-trials
#3
Yanhong Han, Weiyi Yang, Jianke Pan, Lingfeng Zeng, Guihong Liang, Jiongtong Lin, Minghui Luo, Da Guo, Jun Liu
BACKGROUND: The knotless barbed sutures (KBS) are an innovative type of suture that can accelerate the placement of sutures and eliminate knot tying. Whether the KBS are safe and efficient in total joint arthroplasty (TJA) remains controversial. Therefore, we conducted a meta-analysis to evaluate its efficacy and safety. METHODS: Randomized-controlled trials (RCTs) were identified from the PubMed, Embase, and Cochrane Library databases up to October 2017. The Cochrane risk of bias tool was used to assess methodological quality...
June 16, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29909437/clarification-of-governance-relevant-to-the-sustainable-management-of-marine-species-and-habitats-within-the-united-kingdom-an-overview-of-regional-national-and-international-authorities-advisories-legislation-and-designation-types-with-summary-schematic-tool
#4
C L Mackenzie, J Vad, R MacPherson
Marine management developments are occurring across the United Kingdom with the major aim to ensure economic growth and security of marine resources via the provision of legislative guidelines for sustainable management of activities within the marine environment. Many of these directives also provide guidance for maintaining ecologically valuable and/or endangered species and habitats that exist alongside, and may also support, marine activities/use. Marine governance is largely guided by several key directives laid out and implemented by governing authorities of Europe, the United Kingdom and those countries comprising the United Kingdom, and in line with several international conventions...
June 17, 2018: Environmental Management
https://www.readbyqxmd.com/read/29909372/an-international-qualitative-study-exploring-patients-experiences-of-cutaneous-leishmaniasis-study-set-up-and-protocol
#5
Astrid Christine Erber, Byron Arana, Issam Bennis, Afif Ben Salah, Aicha Boukthir, Maria Del Mar Castro Noriega, Mamoudou Cissé, Gláucia Fernandes Cota, Farhad Handjani, Mairie Guizaw Kebede, Trudie Lang, Liliana López Carvajal, Kevin Marsh, Dalila Martinez Medina, Emma Plugge, Piero Olliaro
INTRODUCTION: Lack of investments in drug development, lack of standardisation of clinical trials and the complexity of disease presentations contribute to the current lack of effective, safe and adapted treatments for cutaneous leishmaniasis (CL). One aspect concerns outcomes affecting patients' quality of life (QoL): these are hardly assessed in trials, despite potential functional and/or aesthetic impairment caused by CL, which typically affects disadvantaged and vulnerable people living in rural areas...
June 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29909339/design-and-synthesis-of-novel-benzenesulfonamide-containing-1-2-3-triazoles-as-potent-human-carbonic-anhydrase-isoforms-i-ii-iv-and-ix-inhibitors
#6
Rajiv Kumar, Lalit Vats, Silvia Bua, Claudiu T Supuran, Pawan K Sharma
In a quest to discover new biologically active compounds, a series of twenty novel heterocyclic derivatives substituted at position 5 with -H (7a-7j) or -CF3 (8a-8j), bearing benzenesulfonamide at N-1 position and various aroyl groups at position 4 of the 1,2,3-triazole ring was synthesized and screened for their carbonic anhydrase (CA, EC 4.2.1.1) inhibition potential against four human (h) isoforms hCA I, II, IV and IX. All the compounds (7a-7j and 8a-8j) were synthesized via [3+2] cycloaddition reaction from 4-azidobenzenesulfonamide...
June 8, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29909285/efficacy-of-dexamethasone-in-preventing-acute-mountain-sickness-in-copd-patients-randomized-trial
#7
Michael Furian, Mona Lichtblau, Sayaka S Aeschbacher, Bermet Estebesova, Berik Emilov, Ulan Sheraliev, Nuriddin H Marazhapov, Maamed Mademilov, Batyr Osmonov, Maya Bisang, Stefanie Ulrich, Tsogyal D Latshang, Silvia Ulrich, Talant M Sooronbaev, Konrad E Bloch
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) may experience acute mountain sickness (AMS) and other altitude-related adverse health effects (ARAHE) when travelling to high altitude. We evaluated whether dexamethasone, a drug used for AMS prevention in healthy individuals, would prevent AMS/ARAHE in COPD. METHODS: In this placebo-controlled, double-blind, parallel-design trial COPD patients, GOLD grade 1-2, living below 800m, were randomized to receive dexamethasone (8mg/day) or placebo starting on the day before ascent and while staying in a high altitude clinic at 3100m for 2 days...
June 14, 2018: Chest
https://www.readbyqxmd.com/read/29909266/perinatal-mortality-or-severe-neonatal-encephalopathy-among-normally-formed-singleton-pregnancies-according-to-obstetric-risk-status-is-low-risk-the-new-high-risk-a-population-based-cohort-study
#8
Niamh M Joyce, Elizabeth Tully, Colin Kirkham, Patrick Dicker, Fionnuala M Breathnach
OBJECTIVE: To evaluate the capacity of the current system of obstetric risk stratification at the outset of pregnancy to predict severe adverse perinatal outcome. STUDY DESIGN: This retrospective cohort study of singleton pregnancies over a five year period (2009-2013) was performed at the Rotunda Hospital, Dublin, Ireland. High-risk or low-risk status was assigned retrospectively to a large consecutive cohort of women with a normally-formed singleton pregnancy on the basis of factors analyzed at the first prenatal hospital visit...
June 5, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29909256/task-induced-gamma-band-effect-in-type-ii-focal-cortical-dysplasia-an-exploratory-study
#9
Sabrine Souci, Mathilde Petton, Julien Jung, Pierre Bourdillon, Romain Bouet, Aurélie Richard-Mornas, Nathalie Streichenberger, Hélène Catenoix, Alexandra Montavont, Jean Isnard, Marc Guenot, Philippe Kahane, Jean-Philippe Lachaux, Sylvain Rheims
OBJECTIVE: Few data are available about the functionality of type II focal cortical dysplasia (FCD). Identification of high-frequency activities (HFAs) induced by cognitive tasks has been proposed as an additional way to map cognitive functions in patients undergoing presurgical evaluation using stereoelectroencephalography (SEEG). However, the repetitive subcontinuous spiking pattern which characterizes type II FCD might limit the reliability of this approach, and its feasibility in these patients remains to be evaluated...
June 14, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29909156/high-dose-influenza-vaccine-to-reduce-clinical-outcomes-in-high-risk-cardiovascular-patients-rationale-and-design-of-the-invested-trial
#10
Orly Vardeny, Jacob A Udell, Jacob Joseph, Michael E Farkouh, Adrian F Hernandez, Alison J McGeer, H Keipp Talbot, Deepak L Bhatt, Christopher P Cannon, Shaun G Goodman, Inder Anand, David L DeMets, Jon Temte, Janet Wittes, Kristin Nichol, Clyde W Yancy, J Michael Gaziano, Lawton S Cooper, KyungMann Kim, Scott D Solomon
BACKGROUND: Influenza leads to significant cardiopulmonary morbidity and mortality-particularly in patients with cardiovascular disease-that may be prevented with a standard influenza vaccine. However, patients with cardiovascular conditions have a reduced immune response to influenza vaccine, potentially resulting in reduced effectiveness for preventing clinical events. High-dose vaccine augments immune response in cardiac patients, suggesting that a high-dose influenza vaccination strategy may further reduce morbidity and mortality...
May 23, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29909105/rationale-and-design-of-the-strain-surveillance-of-chemotherapy-for-improving-cardiovascular-outcomes-succour-trial
#11
Tomoko Negishi, Paaladinesh Thavendiranathan, Kazuaki Negishi, Thomas H Marwick
OBJECTIVES: This study sought to evaluate the hypothesis that global longitudinal strain (GLS) guidance of cardioprotective therapy would improve cardiac function of at-risk patients undergoing potentially cardiotoxic chemotherapy, compared with usual care. BACKGROUND: The conventional criteria for diagnosis of chemotherapy-related cardiac dysfunction (CTRCD) are dependent on the recognition of heart failure symptoms and/or changes in left ventricular ejection fraction...
June 8, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29909090/pclys-i3-an-invertebrate-lysozyme-is-involved-in-the-antibacterial-immunity-of-the-red-swamp-crayfish-procambarus-clarkii
#12
Yan Liu, Ying-Hao Zhang, Tong Li, Xiao-Tong Cao, Yang Zhou, Jun-Fa Yuan, Ze-Mao Gu, Jiang-Feng Lan
Antimicrobial peptides (AMPs) play important roles in innate immunity against pathogens and lysozymes are a particularly type of AMP. Lysozymes are hydrolytic enzymes that are characterized by their ability to cleave the beta-(1,4)-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan, which is the major bacterial cell wall polymer. In this work, a lysozyme was identified from Procambarus clarkii and designated PcLys-i3. Quantitative RT-PCR was used to analyze the tissue distribution and expression profiles of PcLys-i3...
May 31, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29909083/human-ipsc-derived-neuronal-models-for-in-vitro-neurotoxicity-assessment
#13
Anke M Tukker, Fiona M J Wijnolts, Aart de Groot, Remco H S Westerink
Neurotoxicity testing still relies on ethically debated, expensive and time consuming in vivo experiments, which are unsuitable for high-throughput toxicity screening. There is thus a clear need for a rapid in vitro screening strategy that is preferably based on human-derived neurons to circumvent interspecies translation. Recent availability of commercially obtainable human induced pluripotent stem cell (hiPSC)-derived neurons and astrocytes holds great promise in assisting the transition from the current standard of rat primary cortical cultures to an animal-free alternative...
June 14, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29909057/study-design-and-protocol-for-a-culturally-adapted-cognitive-behavioral-stress-and-self-management-intervention-for-localized-prostate-cancer-the-encuentros-de-salud-study
#14
Frank J Penedo, Michael H Antoni, Patricia I Moreno, Lara Traeger, Dolores Perdomo, Jason Dahn, Gregory E Miller, Steve Cole, Julian Orjuela, Edgar Pizarro, Betina Yanez
Almost 2.8 million men in the U.S. are living with prostate cancer (PC), accounting for 40% of all male cancer survivors. Men diagnosed with prostate cancer may experience chronic and debilitating treatment side effects, including sexual and urinary dysfunction, pain and fatigue. Side effects can be stressful and can also lead to poor psychosocial functioning. Prior trials reveal that group-based cognitive behavioral stress and self-management (CBSM) is effective in reducing stress and mitigating some of these symptoms, yet little is known about the effects of culturally-translated CBSM among Spanish-speaking men with PC...
June 14, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29909051/early-prophylactic-antibiotics-for-severe-acute-pancreatitis-a-population-based-cohort-study-using-a-nationwide-database-in-japan
#15
Kazuhiko Nakaharai, Kojiro Morita, Taisuke Jo, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
OBJECTIVES: Previous studies evaluating the clinical benefits of prophylactic antibiotics for severe acute pancreatitis (SAP) have generated inconsistent results due to heterogeneities among the study settings. We determined if early prophylactic antibiotics improved the outcomes of SAP patients using a study designed to overcome these previous methodological weaknesses. METHODS: We conducted a retrospective cohort study of SAP patients discharged between July 2010 and March 2016, using a Japanese nationwide inpatient database...
June 13, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29909049/high-speed-resistance-training-in-elderly-women-effects-of-cluster-training-sets-on-functional-performance-and-quality-of-life
#16
Rodrigo Ramirez-Campillo, Cristian Alvarez, Antonio Garcìa-Hermoso, Carlos Celis-Morales, Robinson Ramirez-Velez, Paulo Gentil, Mikel Izquierdo
OBJECTIVE: To compare the effects of 12 weeks of high-speed resistance training on functional performance and quality of life in elderly women when using either a traditional-set (TS) or a cluster-set (CS) configuration for inter-set rest. METHODS: Three groups of subjects were formed by block-design randomization as follows: (i) control group (CG, n = 17; age, 66.5 ± 5.4 years); (ii) 12-week high-speed resistance training group under a CS configuration (CSG, n = 15; age, 67...
June 14, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29909035/bacterial-cellulose-lignin-composite-hydrogel-as-a-promising-agent-in-chronic-wound-healing
#17
Danica Zmejkoski, Dragica Spasojević, Irina Orlovska, Natalia Kozyrovska, Marina Soković, Jasmina Glamočlija, Svetlana Dmitrović, Branko Matović, Nikola Tasić, Vuk Maksimović, Mikhail Sosnin, Ksenija Radotić
Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones...
June 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29909007/early-emergence-of-de-novo-egfr-t790-m-gatekeeper-mutations-during-erlotinib-treatment-in-pc9-non-small-cell-lung-cancer-cells
#18
Sujin Kim, Angela Kj Park, Jeonghee Cho
The emergence of the T790 M gatekeeper mutation in the Epidermal Growth Factor Receptor (EGFR) gene is an important mechanism that can lead to the acquired resistance to EGFR-targeted tyrosine kinase inhibitors such as erlotinib or gefitinib. These drugs have been used in treating a subset of non-small cell lung cancer (NSCLC) patients harboring EGFR activating mutations. Here we investigated the paths leading to the acquisition of the T790 M mutation by establishing an erlotinib resistant PC9 cell model harboring ectopically introduced EGFR cDNA...
June 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29908991/mage-a3-immunotherapeutic-as-adjuvant-therapy-for-patients-with-resected-mage-a3-positive-stage-iii-melanoma-derma-a-double-blind-randomised-placebo-controlled-phase-3-trial
#19
Brigitte Dreno, John F Thompson, Bernard Mark Smithers, Mario Santinami, Thomas Jouary, Ralf Gutzmer, Evgeny Levchenko, Piotr Rutkowski, Jean-Jacques Grob, Sergii Korovin, Kamil Drucis, Florent Grange, Laurent Machet, Peter Hersey, Ivana Krajsova, Alessandro Testori, Robert Conry, Bernard Guillot, Wim H J Kruit, Lev Demidov, John A Thompson, Igor Bondarenko, Jaroslaw Jaroszek, Susana Puig, Gabriela Cinat, Axel Hauschild, Jelle J Goeman, Hans C van Houwelingen, Fernando Ulloa-Montoya, Andrea Callegaro, Benjamin Dizier, Bart Spiessens, Muriel Debois, Vincent G Brichard, Jamila Louahed, Patrick Therasse, Channa Debruyne, John M Kirkwood
BACKGROUND: Despite newly approved treatments, metastatic melanoma remains a life-threatening condition. We aimed to evaluate the efficacy of the MAGE-A3 immunotherapeutic in patients with stage IIIB or IIIC melanoma in the adjuvant setting. METHODS: DERMA was a phase 3, double-blind, randomised, placebo-controlled trial done in 31 countries and 263 centres. Eligible patients were 18 years or older and had histologically proven, completely resected, stage IIIB or IIIC, MAGE-A3-positive cutaneous melanoma with macroscopic lymph node involvement and an Eastern Cooperative Oncology Group performance score of 0 or 1...
June 13, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29908990/development-and-validation-of-response-markers-to-predict-survival-and-pleurodesis-success-in-patients-with-malignant-pleural-effusion-promise-a-multicohort-analysis
#20
Ioannis Psallidas, Nikolaos I Kanellakis, Stephen Gerry, Marie Laëtitia Thézénas, Philip D Charles, Anastasia Samsonova, Herbert B Schiller, Roman Fischer, Rachelle Asciak, Robert J Hallifax, Rachel Mercer, Melissa Dobson, Tao Dong, Ian D Pavord, Gary S Collins, Benedikt M Kessler, Harvey I Pass, Nick Maskell, Georgios T Stathopoulos, Najib M Rahman
BACKGROUND: The prevalence of malignant pleural effusion is increasing worldwide, but prognostic biomarkers to plan treatment and to understand the underlying mechanisms of disease progression remain unidentified. The PROMISE study was designed with the objectives to discover, validate, and prospectively assess biomarkers of survival and pleurodesis response in malignant pleural effusion and build a score that predicts survival. METHODS: In this multicohort study, we used five separate and independent datasets from randomised controlled trials to investigate potential biomarkers of survival and pleurodesis...
June 13, 2018: Lancet Oncology
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