Mitsuhiro Shinada, Hisashi Suzuki, Masayuki Hanyu, Chika Igarashi, Hiroki Matsumoto, Masashi Takahashi, Fukiko Hihara, Tomoko Tachibana, Chizuru Sogawa, Ming-Rong Zhang, Tatsuya Higashi, Hidemitsu Sato, Hiroaki Kurihara, Yukie Yoshii, Yoshihiro Doi
[64 Cu]Cu-diacetyl-bis( N 4 -methylthiosemicarbazone) ([64 Cu]Cu-ATSM) is a radioactive hypoxia-targeting therapeutic agent being investigated in clinical trials for malignant brain tumors. For the quality management of [64 Cu]Cu-ATSM, understanding trace metal impurities' effects on the chelate formation of 64 Cu and ATSM is important. In this study, we conducted coordination chemistry studies on metal-ATSM complexes. First, the effects of nonradioactive metal ions (Cu2+ , Ni2+ , Zn2+ , and Fe2+ ) on the formation of [64 Cu]Cu-ATSM were evaluated...
December 21, 2023: Pharmaceuticals