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https://www.readbyqxmd.com/read/27900813/anesthesia-maintenance-with-induction-dose-only-sevoflurane-during-pediatric-ophthalmic-examination-comparison-with-standard-low-flow-technique-through-a-randomized-controlled-trial
#1
Priyankar K Datta, Renu Sinha, Bikash Ranjan Ray, Venkateswaran Jambunathan, Riddhi Kundu
BACKGROUND: Sevoflurane is preferred for pediatric day care procedures. However, financial and environmental costs remain major limitations. Induction dose of sevoflurane could itself be sufficient for maintaining anesthesia with low fresh gas flow during short noninvasive procedures. METHODS: Fifty children, aged 1-5 years, scheduled for ophthalmic examination under anesthesia, were randomized into two groups. All children were induced with 8% sevoflurane in O2 : N2 O (40 : 60)...
November 30, 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/27892808/self-reported-impulsivity-in-huntington-s-disease-patients-and-relationship-to-executive-dysfunction-and-reward-responsiveness
#2
Patricia L Johnson, Geoffrey F Potts, Juan Sanchez-Ramos, Cynthia R Cimino
INTRODUCTION: Few studies have directly investigated impulsivity in Huntington's disease (HD) despite known changes in dopaminergic and frontal functioning, changes that have been associated with impulsivity in other disorders and in the normal population. This study sought to further categorize impulsivity in HD through examining differences in self-reported impulsivity between community controls and HD patients, the relationship between executive dysfunction and impulsivity, and the relationship of a reward/punishment behavioral inhibition task in relation to these self-report measures...
November 28, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27871631/-benefit-of-general-anesthesia-monitored-by-bispectral-index-compared-with-monitoring-guided-only-by-clinical-parameters-systematic-review-and-meta-analysis
#3
Carlos Rogério Degrandi Oliveira, Wanderley Marques Bernardo, Victor Moisés Nunes
BACKGROUND: The bispectral index parameter is used to guide the titration of general anesthesia; however, many studies have shown conflicting results regarding the benefits of bispectral index monitoring. The objective of this systematic review with meta-analysis is to evaluate the clinical impact of monitoring with the bispectral index parameter. METHODS: The search for evidence in scientific information sources was conducted during December 2013 to January 2015, the following primary databases: Medline/PubMed, LILACS, Cochrane, CINAHL, Ovid, SCOPUS and TESES...
November 18, 2016: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/27863809/efficacy-and-safety-of-tau-aggregation-inhibitor-therapy-in-patients-with-mild-or-moderate-alzheimer-s-disease-a-randomised-controlled-double-blind-parallel-arm-phase-3-trial
#4
Serge Gauthier, Howard H Feldman, Lon S Schneider, Gordon K Wilcock, Giovanni B Frisoni, Jiri H Hardlund, Hans J Moebius, Peter Bentham, Karin A Kook, Damon J Wischik, Bjoern O Schelter, Charles S Davis, Roger T Staff, Luc Bracoud, Kohkan Shamsi, John M D Storey, Charles R Harrington, Claude M Wischik
BACKGROUND: Leuco-methylthioninium bis(hydromethanesulfonate; LMTM), a stable reduced form of the methylthioninium moiety, acts as a selective inhibitor of tau protein aggregation both in vitro and in transgenic mouse models. Methylthioninium chloride has previously shown potential efficacy as monotherapy in patients with Alzheimer's disease. We aimed to determine whether LMTM was safe and effective in modifying disease progression in patients with mild to moderate Alzheimer's disease...
November 15, 2016: Lancet
https://www.readbyqxmd.com/read/27798860/histone-deacetylase-inhibitors-a-novel-therapeutic-weapon-against-medullary-thyroid-cancer
#5
REVIEW
Christos Damaskos, Serena Valsami, Eleftherios Spartalis, Efstathios A Antoniou, Periklis Tomos, Stefanos Karamaroudis, Theofano Zoumpou, Vasilios Pergialiotis, Konstantinos Stergios, Constantinos Michaelides, Konstantinos Kontzoglou, Despina Perrea, Nikolaos Nikiteas, Dimitrios Dimitroulis
BACKGROUND/AIM: Medullary thyroid cancer (MTC) is highly malignant, metastatic and recurrent, remaining generally incurable, and responsible for approximately 14% of all thyroid carcinoma-related deaths. MTC can metastasize to lymph nodes, trachea and distant organs, such as brain, lungs, liver and bones. MTC cells are resistant to chemotherapy and traditional external therapies are not showing definite clinical benefits. Scientists are trying to understand the molecular background of carcinogenesis and histone deacetylase (HDAC) seems to play a potential role to gene transcription...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27790356/moderate-hypothermia-and-its-effects-in-reducing-the-applied-dose-of-anesthetics-for-patients-with-opium-dependence-in-cardiac-surgery-a-randomized-controlled-trial
#6
Reza Jalaian Taghadomi, Ebrahim Golmakani, Kambiz Alizadeh, Behrooz Mottahedi, Ali Rahdari, Shima Sheybani
BACKGROUND: An increasing number of patients addicted to opium are experiencing awareness during coronary artery bypass surgery (CABG) as a result of tolerance to anesthetics. OBJECTIVES: This research was primarily intended to determine the potential diminishing effects of moderate hypothermia on anesthetic dosage and recall of anesthesia during the procedure. METHODS: In this double-blind randomized controlled trial, a total of 80 CABG candidates with known addiction to opium were divided into two groups: one normothermic (N) and the other moderately hypothermic (H), both undergoing induction as well as close monitoring from September 2014 to January 2016...
September 2016: Electronic Physician
https://www.readbyqxmd.com/read/27756208/effect-of-the-severity-of-liver-dysfunction-on-the-minimum-alveolar-concentration-of-sevoflurane-responding-to-an-electronic-stimulation-in-cirrhotic-patients
#7
Yan Yin, Hong Xiao, Jirimutuya Han, Weiyi Zhang, Jianguo Cheng, Tao Zhu
BACKGROUND: It has been observed that patients with liver dysfunction need lower dose anesthetic compared patients with normal liver function. The minimum amount of volatile anesthetic to achieve an optimal depth of anesthesia for these patients is still unclear. In this study, Minimum alveolar concentration (MAC) of the sevoflurane was determined using an electric stimulation and the effect of severity of liver dysfunction on the MAC was observed in cirrhotic patients. METHODS: Thirty patients undergoing upper abdominal surgery were divided into the following groups: group N (normal liver function), group A (Child-Pugh grade A) and group B (Child-Pugh grade B-C)...
October 18, 2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27713709/effect-of-a-mindfulness-training-program-on-the-impulsivity-and-aggression-levels-of-adolescents-with-behavioral-problems-in-the-classroom
#8
Clemente Franco, Alberto Amutio, Luís López-González, Xavier Oriol, Cristina Martínez-Taboada
Objective: The aim of the present study was to analyze the effects of a mindfulness training psycho-educative program on impulsivity and aggression levels in a sample of high school students. Methods: A randomized controlled trial with pre-test-post-test measurements was applied to an experimental group and a control group (waiting list). The Barratt Impulsivity Scale (BIS-11) Patton et al. (1995) and the Aggression Questionnaire (Buss and Perry, 1992) were used. Results: Statistical analyses showed a significant decrease in the levels of impulsivity and aggressiveness in the experimental group compared with the control group...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27644009/the-feasibility-of-a-completely-automated-total-iv-anesthesia-drug-delivery-system-for-cardiac-surgery
#9
Cedrick Zaouter, Thomas M Hemmerling, Romain Lanchon, Emanuela Valoti, Alain Remy, Sébastien Leuillet, Alexandre Ouattara
BACKGROUND: In this pilot study, we tested a novel automatic anesthesia system for closed-loop administration of IV anesthesia drugs for cardiac surgical procedures with cardiopulmonary bypass. This anesthesia drug delivery robot integrates all 3 components of general anesthesia: hypnosis, analgesia, and muscle relaxation. METHODS: Twenty patients scheduled for elective cardiac surgery with cardiopulmonary bypass were enrolled. Propofol, remifentanil, and rocuronium were administered using closed-loop feedback control...
October 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27625484/tracheal-intubation-with-volatile-induction-and-target-bispectral-index-of-25-versus-40-a-randomized-clinical-trial
#10
Purva Khandelwal, Kanti Kumar Gombar, Vanita Ahuja, Satinder Gombar
BACKGROUND AND AIMS: A target bispectral index (BIS) value of 40 is considered adequate for depth of anesthesia, but no consensus exists regarding BIS value for tracheal intubation without neuromuscular blocking drugs. The aim of this randomized, double-blinded study was to compare the total duration from sevoflurane induction to tracheal intubation at a BIS value of 25 or 40. MATERIAL AND METHODS: This study was a prospective, randomized and observer-blinded clinical trial...
July 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/27620902/application-of-bioimpedance-spectroscopy-in-asian-dialysis-patients-abisad-iii-a-randomized-controlled-trial-for-clinical-outcomes
#11
Chen Huan-Sheng, Chang Yeong-Chang, Hsieh Ming-Hsing, Tseng Fan-Lieh, Lin Chu-Cheng, Wu Tsai-Kun, Chen Hung-Ping, Hung Sze-Hung, Chiu Hsien-Chang, Lee Chia-Chen, Hou Chun-Cheng, Cheng Chun-Ting, Liou Hung-Hsiang, Lin Chun-Ju, Lim Paik-Seong
PURPOSE: Fluid management with body composition monitor based on bioimpedance spectroscopy (BCM-BIS) has been found to be beneficial for dialysis patients. We conducted a study to provide an algorithm for the determination of post-dialysis target weight (PDTW) and to evaluate whether this approach could improve clinical outcomes compared to patients who had PDTW decided clinically. METHODS: Two hundred and ninety-eight dialysis patients participated in this 1-year randomized controlled trial...
November 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27606612/determination-of-loss-of-consciousness-a-comparison-of-clinical-assessment-bispectral-index-and-electroencephalogram-an-observational-study
#12
Eva-Lena Zetterlund, Henrik Gréen, Anna Oscarsson, Svante Vikingsson, Magnus Vrethem, Maj-Lis Lindholm, Christina Eintrei
BACKGROUND: Computer-processed algorithms of encephalographic signals are widely used to assess the depth of anaesthesia. However, data indicate that the bispectral index (BIS), a processed electroencephalography monitoring system, may not be reliable for assessing the depth of anaesthesia. OBJECTIVE: The aim of this study was to evaluate the ability of the BIS monitoring system to assess changes in the level of unconsciousness, specifically during the transition from consciousness to unconsciousness, in patients undergoing total intravenous anaesthesia with propofol...
December 2016: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/27605553/heat-shock-protein-based-therapy-as-a-potential-candidate-for-treating-the-sphingolipidoses
#13
Thomas Kirkegaard, James Gray, David A Priestman, Kerri-Lee Wallom, Jennifer Atkins, Ole Dines Olsen, Alexander Klein, Svetlana Drndarski, Nikolaj H T Petersen, Linda Ingemann, David A Smith, Lauren Morris, Claus Bornæs, Signe Humle Jørgensen, Ian Williams, Anders Hinsby, Christoph Arenz, David Begley, Marja Jäättelä, Frances M Platt
Lysosomal storage diseases (LSDs) often manifest with severe systemic and central nervous system (CNS) symptoms. The existing treatment options are limited and have no or only modest efficacy against neurological manifestations of disease. We demonstrate that recombinant human heat shock protein 70 (HSP70) improves the binding of several sphingolipid-degrading enzymes to their essential cofactor bis(monoacyl)glycerophosphate in vitro. HSP70 treatment reversed lysosomal pathology in primary fibroblasts from 14 patients with eight different LSDs...
September 7, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27588943/comparable-efficacy-of-a-1-l-peg-and-ascorbic-acid-solution-administered-with-bisacodyl-versus-a-2-l-peg-and-ascorbic-acid-solution-for-colonoscopy-preparation-a-prospective-randomized-and-investigator-blinded-trial
#14
Ji Eun Kwon, Jung Won Lee, Jong Pil Im, Ji Won Kim, Su Hwan Kim, Seong-Joon Koh, Byeong Gwan Kim, Kook Lae Lee, Sang Gyun Kim, Joo Sung Kim, Hyun Chae Jung
BACKGROUND: Two liters of polyethylene glycol (PEG) solution administered with ascorbic acid (Asc) can provide efficacy similar to that of a 4-L PEG solution for colonoscopy preparation. In addition, oral bisacodyl (Bis) has been shown to reduce the volume of PEG needed for a bowel preparation with comparable efficacy. This study aimed to compare the efficacy, tolerability and safety of a 2-L PEG solution mixed with Asc versus the combination of Bis, Asc and a 1-L PEG solution. METHODS: This was a prospective, randomized, multi-centre, single-blind, non-inferiority trial...
2016: PloS One
https://www.readbyqxmd.com/read/27559084/combination-therapy-with-bptes-nanoparticles-and-metformin-targets-the-metabolic-heterogeneity-of-pancreatic-cancer
#15
Amira Elgogary, Qingguo Xu, Brad Poore, Jesse Alt, Sarah C Zimmermann, Liang Zhao, Jie Fu, Baiwei Chen, Shiyu Xia, Yanfei Liu, Marc Neisser, Christopher Nguyen, Ramon Lee, Joshua K Park, Juvenal Reyes, Thomas Hartung, Camilo Rojas, Rana Rais, Takashi Tsukamoto, Gregg L Semenza, Justin Hanes, Barbara S Slusher, Anne Le
Targeting glutamine metabolism via pharmacological inhibition of glutaminase has been translated into clinical trials as a novel cancer therapy, but available drugs lack optimal safety and efficacy. In this study, we used a proprietary emulsification process to encapsulate bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES), a selective but relatively insoluble glutaminase inhibitor, in nanoparticles. BPTES nanoparticles demonstrated improved pharmacokinetics and efficacy compared with unencapsulated BPTES...
September 6, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27484701/effects-of-dexmedetomidine-on-motor-and-somatosensory-evoked-potentials-in-patients-with-thoracic-spinal-cord-tumor-a-randomized-controlled-trial
#16
Yan Li, Lingzhong Meng, Yuming Peng, Hui Qiao, Lanjun Guo, Ruquan Han, Adrian W Gelb
BACKGROUND: We hypothesized that the addition of dexmedetomidine in a clinically relevant dose to propofol-remifentanil anesthesia regimen does not exert an adverse effect on motor-evoked potentials (MEP) and somatosensory-evoked potentials (SSEP) in adult patients undergoing thoracic spinal cord tumor resection. METHODS: Seventy-one adult patients were randomized into three groups. Propofol group (n = 25): propofol-remifentanil regimenand the dosage was adjusted to maintain the bispectral index (BIS) between 40 and 50...
August 2, 2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27484227/dexmedetomidine-ketamine-versus-dexmedetomidine-midazolam-fentanyl-for-monitored-anesthesia-care-during-chemoport-insertion-a-prospective-randomized-study
#17
Eun Hee Chun, Myeong Jae Han, Hee Jung Baik, Hahck Soo Park, Rack Kyung Chung, Jong In Han, Hun Jung Lee, Jong Hak Kim
BACKGROUND: Dexmedetomidine as a sole agent showed limited use for painful procedures due to its insufficient sedative/analgesic effect, pronounced hemodynamic instability and prolonged recovery. The aim of this study was to compare the effects of dexmedetomidine-ketamine (DK) versus dexmedetomidine-midazolam-fentanyl (DMF) combination on the quality of sedation/analgesia and recovery profiles for monitored anesthesia care (MAC). METHODS: Fifty six patients undergoing chemoport insertion were randomly assigned to group DK or DMF...
2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27464979/a-procedural-electroencephalogram-simulator-for-evaluation-of-anesthesia-monitors
#18
Christian Leth Petersen, Matthias Görges, Roslyn Massey, Guy Albert Dumont, J Mark Ansermino
BACKGROUND: Recent research and advances in the automation of anesthesia are driving the need to better understand electroencephalogram (EEG)-based anesthesia end points and to test the performance of anesthesia monitors. This effort is currently limited by the need to collect raw EEG data directly from patients. METHODS: A procedural method to synthesize EEG signals was implemented in a mobile software application. The application is capable of sending the simulated signal to an anesthesia depth of hypnosis monitor...
July 26, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27460746/effect-of-different-doses-of-dexmedetomidine-on-median-effective-concentration-of-propofol-for-anesthesia-induction-a-randomized-controlled-trial
#19
X-N Zhao, J-H Ran, A R Bajracharya, M-Y Ma
OBJECTIVE: Dexmedetomidine, a highly selective α2-adrenergic receptor agonist with sedative and analgesic properties, is used as an anesthetic adjunct. We determined the effects of different dexmedetomidine doses on the median effective concentration (EC50) of propofol and bispectral index (BIS) values during anesthesia induction. PATIENTS AND METHODS: This randomized, prospective, case-control clinical trial involved 120 patients (56 women; physical status, American Society of Anesthesiologists grades I or II) scheduled to undergo surgery requiring general anesthesia from July 15th, 2014 to June 15th, 2015...
July 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27421654/treatment-of-critically-sized-femoral-defects-with-recombinant-bmp-2-delivered-by-a-modified-mpeg-plga-biodegradable-thermosensitive-hydrogel
#20
Kuo-Ti Peng, Meng-Yow Hsieh, Carl T Lin, Chin-Fu Chen, Mel S Lee, Yi-You Huang, Pey-Jium Chang
BACKGROUND: Reconstruction of a segmental fracture with massive bone loss is still a challenge for orthopaedic surgeons. The aim of our study was to develop a suitable biodegradable thermosensitive hydrogel system as a carrier for bone morphogenetic protein (BMP)-2 delivery in the treatment of critical-sized femoral defects. METHODS: A block copolymer composed of monomethoxypoly(ethylene glycol) (mPEG), poly(lactic-co-glycolic acid) (PLGA) and 2, 2'-Bis (2-oxazolin) (Box) was synthesized by ring opening polymerization...
2016: BMC Musculoskeletal Disorders
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