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https://www.readbyqxmd.com/read/29902969/bispectral-index-to-guide-induction-of-anesthesia-a-randomized-controlled-study
#1
Dirk Rüsch, Christian Arndt, Leopold Eberhart, Scarlett Tappert, Dennis Nageldick, Hinnerk Wulf
BACKGROUND: It is unknown to what extent hypotension frequently observed following administration of propofol for induction of general anesthesia is caused by overdosing propofol. Unlike clinical signs, electroencephalon-based cerebral monitoring allows to detect and quantify an overdose of hypnotics. Therefore, we tested whether the use of an electroencephalon-based cerebral monitoring will cause less hypotension following induction with propofol. METHODS: Subjects were randomly assigned to a bispectral index (BIS)-guided (target range 40-60) or to a weight-related (2 mg...
June 15, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29890956/sputum-signatures-for-invasive-pulmonary-aspergillosis-in-patients-with-underlying-respiratory-diseases-spared-study-protocol-for-a-prospective-diagnostic-trial
#2
Wei Xiao, De-Ying Gong, Bing Mao, Xin-Miao Du, Lin-Li Cai, Min-Yu Wang, Juan-Juan Fu
BACKGROUND: Invasive pulmonary aspergillosis (IPA) has been increasingly reported in patients with underlying respiratory diseases (URD). Early diagnosis of IPA is crucial for mortality reduction and improved prognosis, yet remains difficult. Existing diagnostic tools for IPA largely rely on the detection of biomarkers based on serum or bronchoalveolar lavage fluid (BALF), both of which have their limitations. The use of sputum sample is non-invasive, and Aspergillus detection is feasible; however, the usefulness of sputum biomarkers for the diagnosis of IPA, especially in patients with URD, has not been systematically studied...
June 11, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29871891/emergency-department-alcohol-intervention-effects-on-dating-violence-and-depression
#3
Quyen M Ngo, Andria B Eisman, Maureen A Walton, Yasamin Kusunoki, Stephen T Chermack, Vijay Singh, Rebecca Cunningham
OBJECTIVES: With this study, we examined secondary outcomes of an emergency department (ED)-based brief intervention (BI) on dating violence perpetration and victimization and depression symptoms over 3, 6, and 12 months. METHODS: ED patients (14-20 years) were screened for risk drinking. Patients who received positive screen results were randomly assigned to a computer BI ( n = 277), therapist BI ( n = 278), or control condition ( n = 281). After the 3-month assessment, participants were randomly assigned to receive the post-ED BI or control condition...
June 5, 2018: Pediatrics
https://www.readbyqxmd.com/read/29843553/efficacy-of-ferrous-bis-glycinate-versus-ferrous-glycine-sulphate-in-the-treatment-of-iron-deficiency-anemia-with-pregnancy-a-randomized-double-blind-clinical-trial
#4
Ahmed Abbas, Safaa A Abdelbadee, Ahmed Alanwar, Sayed Mostafa
OBJECTIVE: The current study aims to compare the efficacy and tolerability of oral ferrous bis-glycinate versus ferrous glycine sulphate in the treatment of iron deficiency anemia (IDA) with pregnancy. METHODS: A randomized double-blind clinical trial ( NCT02590224 ) conducted at a tertiary University Hospital in the period between 1 January 2016 and 31 July 2017 included pregnant women at 14-18 weeks of gestation with mild to moderate IDA. Patients were randomized into two groups: (Group I) received oral ferrous bis-glycinate tablets once daily for eight consecutive weeks and (Group II) received oral ferrous glycine sulphate capsules in the same dose and duration...
May 29, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29806946/wtx101-an-investigational-drug-for-the-treatment-of-wilson-disease
#5
Karl Heinz Weiss, Anna Członkowska, Peter Hedera, Peter Ferenci
Wilson disease (WD) is a genetic disorder in which excess toxic copper accumulates in the liver, brain, and other tissues leading to severe and life-threatening symptoms. Copper overload can be assessed as non-ceruloplasmin-bound copper non-ceruloplasmin-bound copper (NCC) in blood. Current therapies are limited by efficacy, safety concerns, and multiple-daily dosing. Areas covered: This article reviews the literature on WTX101 (bis-choline tetrathiomolybdate), an oral first-in-class copper-protein-binding agent in development for the treatment of WD...
June 8, 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29803726/estradiol-dimer-inhibits-tubulin-polymerization-and-microtubule-dynamics
#6
Michal Jurášek, Markéta Černohorská, Jiří Řehulka, Vojtěch Spiwok, Tetyana Sulimenko, Eduarda Dráberová, Maria Darmostuk, Soňa Gurská, Ivo Frydrych, Renata Buriánová, Tomáš Ruml, Marián Hajdúch, Petr Bartůněk, Pavel Dráber, Petr Džubák, Pavel B Drašar, David Sedlák
Microtubule dynamics is one of the major targets for new chemotherapeutic agents. This communication presents the synthesis and biological profiling of steroidal dimers based on estradiol, testosterone and pregnenolone bridged by 2,6-bis(azidomethyl)pyridine between D rings. The biological profiling revealed unique properties of the estradiol dimer including cytotoxic activities on a panel of 11 human cell lines, ability to arrest in the G2/M phase of the cell cycle accompanied with the attenuation of DNA/RNA synthesis...
May 24, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29768360/clinical-efficacy-of-xenon-versus-propofol-a-systematic-review-and-meta-analysis
#7
Yimeng Xia, Hongwei Fang, Jindong Xu, Chenfei Jia, Guorong Tao, Buwei Yu
BACKGROUND: Interest in the anesthetic use of xenon, a noble gas, has waxed and waned for decades, and the clinical effects of xenon are still debated. We performed a meta-analysis to compare the clinical efficacy of xenon with that of propofol. METHODS: Electronic searches were performed through December 2017 using various databases, including PubMed, Embase, and the Cochrane Library. We identified thirteen trials that included a total of 817 patients. RESULTS: Patients treated with xenon had a lower bispectral index (BIS) (weighted mean difference (WMD): -6...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29761891/processed-electroencephalogram-and-evoked-potential-techniques-for-amelioration-of-postoperative-delirium-and-cognitive-dysfunction-following-non-cardiac-and-non-neurosurgical-procedures-in-adults
#8
REVIEW
Yodying Punjasawadwong, Waraporn Chau-In, Malinee Laopaiboon, Sirivimol Punjasawadwong, Pathomporn Pin-On
BACKGROUND: Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) may complicate a patient's postoperative recovery in several ways. Monitoring of processed electroencephalogram (EEG) or evoked potential (EP) indices may prevent or minimize POD and POCD, probably through optimization of anaesthetic doses. OBJECTIVES: To assess whether the use of processed EEG or auditory evoked potential (AEP) indices (bispectral index (BIS), narcotrend index, cerebral state index, state entropy and response entropy, patient state index, index of consciousness, A-line autoregressive index, and auditory evoked potentials (AEP index)) as guides to anaesthetic delivery can reduce the risk of POD and POCD in non-cardiac surgical or non-neurosurgical adult patients undergoing general anaesthesia compared with standard practice where only clinical signs are used...
May 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29758380/predictors-of-positive-drinking-outcomes-among-youth-receiving-an-alcohol-brief-intervention-in-the-emergency-department
#9
Alan K Davis, Brooke J Arterberry, Erin E Bonar, Stephen T Chermack, Frederic C Blow, Rebecca M Cunningham, Maureen A Walton
BACKGROUND: Reducing underage drinking is a public health priority given increased risk for injury and other consequences. Emergency department (ED) visits offer a potential "teachable moment" to initiate interventions among youth engaged in risky drinking. Given mixed findings for alcohol brief interventions (BIs), this paper examined baseline markers of BI response in order to inform future interventions. METHOD: We conducted secondary analyses of data from a randomized controlled trial of an alcohol BI delivered to youth in an ED...
May 5, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29746721/melatonin-for-the-promotion-of-sleep-in-adults-in-the-intensive-care-unit
#10
REVIEW
Sharon R Lewis, Michael W Pritchard, Oliver J Schofield-Robinson, Phil Alderson, Andrew F Smith
BACKGROUND: Patients in the intensive care unit (ICU) experience sleep deprivation caused by environmental disruption, such as high noise levels and 24-hour lighting, as well as increased patient care activities and invasive monitoring as part of their care. Sleep deprivation affects physical and psychological health, and patients perceive the quality of their sleep to be poor whilst in the ICU. Artificial lighting during night-time hours in the ICU may contribute to reduced production of melatonin in critically ill patients...
May 10, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29715600/caudatan-a-an-undescribed-human-kidney-type-glutaminase-inhibitor-with-tetracyclic-flavan-from-ohwia-caudata
#11
Yiwei Sun, Xiaohe Feng, Xuanli Liu, Cheng Qian, Xin Che, Fei Cao, Sanshan Jin, Dali Meng
Human kidney-type glutaminase (KGA) is an important target that is often over expressed in many cancer cells but very few effective inhibitors of this enzyme have yet reached clinical trials. Caudatan A and caudatan B, two undescribed tetracyclic flavans with an unusual ether bond between the C-4 and C-2' were isolated from the roots of Ohwia caudata (Thunb.) H.Ohashi. Caudatan A exhibited stronger inhibitory activity and caudatan B showed moderate effect from the results of inhibitory activities evaluations on KGA...
April 28, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29657696/comparing-effectiveness-of-mindfulness-based-relapse-prevention-with-treatment-as-usual-on-impulsivity-and-relapse-for-methadone-treated-patients-a-randomized-clinical-trial
#12
Mehdi Yaghubi, Fatemeh Zargar, Hossein Akbari
Background: Impulsivity is one of the causes of relapse that can affect treatment outcomes. Studies have shown that addiction treatments can reduce impulsivity in drug-dependent individuals. Studies also have suggested that mindfulness is associated with impulsivity. However, no study has investigated the effectiveness of the mindfulness-based intervention on impulsivity in opioid-dependent individuals. This study aimed to compare the effectiveness of mindfulness-based relapse prevention (MBRP) with treatment as usual (TAU) in terms of impulsivity and relapse for methadone-treated patients...
July 2017: Addiction & Health
https://www.readbyqxmd.com/read/29584464/endophyte-enhanced-phytoremediation-of-dde-contaminated-using-cucurbita-pepo-a-field-trial
#13
N Eevers, J R Hawthorne, J C White, J Vangronsveld, N Weyens
Although the use of the pesticide 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDT) was banned from the mid-1970s, its most abundant and recalcitrant degradation product, 2,2-bis(p-chlorophenyl)-1,1-dichloro-ethylene (DDE), is still present in terrestrial and aquatic ecosystems worldwide. Zucchini (Cucurbita pepo ssp. pepo) has been shown to accumulate high concentrations of DDE and was proposed for phytoremediation of contaminated soils. We performed a field trial covering a full plant life cycle. C. pepo plants inoculated with the plant growth-promoting endophytic strains Sphingomonas taxi UH1, Methylobacterium radiotolerans UH1, Enterobacter aerogenes UH1, or a consortium combining these 3 strains were grown on a DDE-contaminated field for 100 days...
March 21, 2018: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/29582946/-effects-of-cannabis-extract-premedication-on-anesthetic-depth
#14
Carlos Ibera, Ben Shalom, Fayez Saifi, Joshua Shruder, Elyad Davidson
BACKGROUND: Cannabis is the most widely used illicit drug in the world, used by approximately 2.7-4.9% of the world's population, and 7.6-10.2% of Israel's adults. During the past few years, legal systems around the world have enacted large scale adoption of the legalization of both medical and recreational cannabis. Anesthetists should therefore be prepared to treat patients who used cannabis and are undergoing elective or emergency operations. However, the interactions between cannabinoids and general anesthetic agents and the possible implications for patient care are not yet fully understood...
March 2018: Harefuah
https://www.readbyqxmd.com/read/29514524/randomised-comparison-of-silicone-gel-and-onion-extract-gel-for-post-surgical-scars
#15
Taejong Song, Kye Hyun Kim, Kyo Won Lee
To compare the efficacy of silicone gel and onion extract gel on new surgical wounds, we performed a randomised controlled trial evaluating the appearance of the laparoscopic surgical scars of 60 subjects after 12 weeks of two times daily application of either silicone gel or onion extract gel. Objective scar assessment by the Vancouver Scar Scale (VSS) and the Image Panel Scale (IPS) and subjective scar assessment by the Body Image Scale (BIS) and Cosmetic Scale (CS) were performed after 12 weeks of treatment...
March 7, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29484267/pocd-in-patients-receiving-total-knee-replacement-under-deep-vs-light-anesthesia-a-randomized-controlled-trial
#16
Ruixue Hou, Hong Wang, Lianhua Chen, Yimin Qiu, Shitong Li
Objectives: Clinical observation, as well as randomized controlled trials, indicated an increasing rate of postoperative cognitive dysfunction (POCD) with increasing depth of general anesthesia. However, the findings are subject to bias due to varying degree of analgesia. In this trial, we compared the rate of POCD between patients receiving light versus high anesthesia while holding analgesia comparable using nerve block. Methods: Elderly patients (≧60 years) receiving elective total knee replacement were randomized to receive the surgery under general anesthesia at BIS 40-50 (LOBIS group) or BIS 55-65 (HIBIS group)...
February 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29481560/failure-of-fluconazole-in-treating-cutaneous-leishmaniasis-caused-by-leishmania-guyanensis-in-the-brazilian-amazon-an-open-nonrandomized-phase-2-trial
#17
Valeska Albuquerque Francesconi, Fabio Francesconi, Rajendranath Ramasawmy, Gustavo Adolfo Sierra Romero, Maria das Graças Costa Alecrim
BACKGROUND: The treatment of Leishmaniasis caused by Leishmania (Viannia) guyanensis is based on a weak strength of evidence from very few clinical trials and some case series reports. Current treatment guidelines recommend pentamidine isethionate or meglumine antimoniate (Glucantime) as the first-line choices. Both are parenteral drugs with a low therapeutic indexes leading to a high risk of undesired effects. Imidazole derivatives interfere with the production of leishmanial ergosterol, an essential component of their membrane structure...
February 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29464690/bis-monitoring-versus-clinical-assessment-for-sedation-in-mechanically-ventilated-adults-in-the-intensive-care-unit-and-its-impact-on-clinical-outcomes-and-resource-utilization
#18
REVIEW
Rajesh M Shetty, Antonio Bellini, Dhuleep S Wijayatilake, Mark A Hamilton, Rajesh Jain, Sunil Karanth, ArunKumar Namachivayam
BACKGROUND: Patients admitted to intensive care and on mechanical ventilation, are administered sedative and analgesic drugs to improve both their comfort and interaction with the ventilator. Optimizing sedation practice may reduce mortality, improve patient comfort and reduce cost. Current practice is to use scales or scores to assess depth of sedation based on clinical criteria such as consciousness, understanding and response to commands. However these are perceived as subjective assessment tools...
February 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29464504/significant-and-safe-reduction-of-propofol-sedation-dose-for-geriatric-population-undergoing-pacemaker-implantation-randomized-clinical-trial
#19
Ana Luisa Hernandez-Perez, Ana Gabriela Gallardo-Hernandez, German Ordoñez-Espinosa, Beatriz Martinez-Carrillo, Manuel Gerardo Bermudez-Ochoa, Cristina Revilla-Monsalve, Jose Antonio Sanchez-Lopez, Guillemo Saturno-Chiu, Ronald Leder
OBJECTIVE: A previous multidisciplinary pilot study based on computer simulations for the geriatric population showed that a dose of 0.5 mg/kg/h of propofol could sedate patients older than 65 for pacemaker implantation. The present study validates that the pacemaker implantation can be done in the elderly using 0.5-1 mg/kg/h of propofol with hemodynamic stability. METHODS: 66 patients from 65 to 88 years old scheduled for pacemaker implantation were randomly assigned one of three doses of propofol...
February 21, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29433385/intravenous-lidocaine-as-adjuvant-to-general-anesthesia-in-renal-surgery
#20
Mohamed Said Nakhli, Mohamed Kahloul, Taieb Guizani, Chekib Zedini, Ajmi Chaouch, Walid Naija
The role of intraoperative intravenous lidocaine infusion has been previously evaluated for pain relief, inflammatory response, and post-operative recovery, particularly in abdominal surgery. The present study is a randomized double-blinded trial in which we evaluated whether IV lidocaine infusion reduces isoflurane requirement, intraoperative remifentanil consumption and time to post-operative recovery in non-laparoscopic renal surgery. Sixty patients scheduled to undergo elective non-laparoscopic renal surgery under general anesthesia were enrolled to receive either systemic lidocaine infusion (group L: bolus 1...
December 2018: Libyan Journal of Medicine
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