keyword
MENU ▼
Read by QxMD icon Read
search

bis trial

keyword
https://www.readbyqxmd.com/read/28423064/biochemical-evaluation-of-the-anticancer-potential-of-the-polyamine-based-nanocarrier-nano11047
#1
Tracy Murray-Stewart, Elena Ferrari, Ying Xie, Fei Yu, Laurence J Marton, David Oupicky, Robert A Casero
Synthesizing polycationic polymers directly from existing drugs overcomes the drug-loading limitations often associated with pharmacologically inert nanocarriers. We recently described nanocarriers formed from a first-generation polyamine analogue, bis(ethyl)norspermine (BENSpm), that could simultaneously target polyamine metabolism while delivering therapeutic nucleic acids. In the current study, we describe the synthesis and evaluation of self-immolative nanocarriers derived from the second-generation polyamine analogue PG-11047...
2017: PloS One
https://www.readbyqxmd.com/read/28415069/comparison-of-bioimpedance-and-underwater-weighing-body-fat-percentage-before-and-acutely-after-exercise-at-varying-intensities
#2
Brett S Nickerson, Michael R Esco, Brian M Kliszczewicz, Todd J Freeborn
Nickerson, BS, Esco, MR, Kliszczewicz, BM, and Freeborn, TJ. Comparison of bioimpedance and underwater weighing body fat percentage before and acutely after exercise at varying intensities. J Strength Cond Res 31(5): 1395-1402, 2017-The purpose of this study was to compare single-frequency bioelectrical impedance analysis (BIA) and bioimpedance spectroscopy (BIS) with underwater weighing (UWW) body fat percentage (BF%) before (PRE), immediately post (IP), and 60 minutes post (60P) an acute bout of moderate and vigorous aerobic exercise...
May 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28410397/a-bis-sulphamoylated-estradiol-derivative-induces-ros-dependent-cell-cycle-abnormalities-and-subsequent-apoptosis
#3
Michelle Helen Visagie, Iman van den Bout, Anna Margaretha Joubert
Clinical trials have revealed that the potential anticancer agent, 2-methoxyestradiol (2ME2) has limitations due to its low bioavailability. Subsequently, 2ME2 derivatives including (8R,13S,14S,17S)-2-ethyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrane-3,17-diyl bis(sulphamate) (EMBS) have shown improved efficacies in inducing apoptosis. However, no conclusive data exist to explain the mode of action exerted by these drugs. This study investigated the mode of action used by EMBS as a representative of the sulphamoylated 2ME2 derivatives...
2017: PloS One
https://www.readbyqxmd.com/read/28405500/zoledronate-can-induce-colorectal-cancer-microenvironment-expressing-btn3a1-to-stimulate-effector-%C3%AE-%C3%AE-t-cells-with-antitumor-activity
#4
Maria Raffaella Zocchi, Delfina Costa, Roberta Venè, Francesca Tosetti, Nicoletta Ferrari, Simona Minghelli, Roberto Benelli, Stefano Scabini, Emanuele Romairone, Silvia Catellani, Aldo Profumo, Alessandro Poggi
Amino-bis-phosphonates (N-BPs) such as zoledronate (Zol) have been used in anticancer clinical trials due to their ability to upregulate pyrophosphate accumulation promoting antitumor Vγ9Vδ2 T cells. The butyrophilin 3A (BTN3A, CD277) family, mainly the BTN3A1 isoform, has emerged as an important structure contributing to Vγ9Vδ2 T cells stimulation. It has been demonstrated that the B30.2 domain of BTN3A1 can bind phosphoantigens (PAg) and drive the activation of Vγ9Vδ2 T cells through conformational changes of the extracellular domains...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28392828/screening-of-wilson-s-disease-in-a-psychiatric-population-difficulties-and-pitfalls-a-preliminary-study
#5
Caroline Demily, François Parant, David Cheillan, Emmanuel Broussolle, Alice Pavec, Olivier Guillaud, Lioara Restier, Alain Lachaux, Muriel Bost
BACKGROUND: Wilson's disease (WD) is a rare autosomal-recessive, inherited disorder caused by a mutation in the copper-transporting gene ATP7B affecting the liver and nervous system. About 30% of patients with WD may initially present with psychiatric symptoms, and diagnosis can be difficult to establish. The objectives of the present preliminary study were [1] to evaluate the relevance of serum copper (Cu) and ceruloplasmin (Cp) measures in hospitalized patients with psychiatric disorders; and [2] to identify possible mutations in the ATP7B gene in patients with abnormal biological copper profile...
2017: Annals of General Psychiatry
https://www.readbyqxmd.com/read/28382023/antiprotozoal-effect-of-saponins-in-the-rumen-can-be-enhanced-by-chemical-modifications-in-their-structure
#6
Eva Ramos-Morales, Gabriel de la Fuente, Stephane Duval, Christof Wehrli, Marc Bouillon, Martina Lahmann, David Preskett, Radek Braganca, Charles J Newbold
The antiprotozoal effect of saponins is transitory, as when saponins are deglycosylated to the sapogenin by rumen microorganisms they become inactive. We postulated that the substitution of the sugar moiety of the saponin with small polar residues would produce sapogen-like analogs which might be resistant to degradation in the rumen as they would not be enzymatically cleaved, allowing the antiprotozoal effect to persist over time. In this study, we used an acute assay based on the ability of protozoa to break down [(14)C] leucine-labeled Streptococcus bovis and a longer term assay based on protozoal motility over 24 h to evaluate both the antiprotozoal effect and the stability of this effect with fifteen hederagenin bis-esters esterified with two identical groups, and five cholesterol and cholic acid based derivatives carrying one to three succinate residues...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28361391/relation-between-bispectral-index-measurements-of-anesthetic-depth-and-postoperative-mortality-a-meta-analysis-of-observational-studies
#7
Andres Zorrilla-Vaca, Ryan J Healy, Christopher L Wu, Michael C Grant
INTRODUCTION: The association between anesthesia depth and mortality is still controversial. There are a number of narrative reviews on this topic that affirm this association, but their conclusions were based only on qualitative analyses. The aim of this meta-analysis of observational studies was to examine the potential association between depth of anesthesia as a low bispectral index (BIS) and mortality using appropriate quantitative methods. METHODS: The literature was systematically reviewed in three main electronic databases (MEDLINE, EMBASE, Google Scholar) to identify all articles from inception through December 2015 regarding the association between depth of anesthesia and mortality...
March 30, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28355756/-effect-of-intravenous-infusion-with-lidocaine-on-rapid-recovery-of-laparoscopic-cholecystectomy
#8
X Z Chen, Q B Lou, C C Sun, W S Zhu, J Li
Objective: To investigate the effect of intravenous infusion with lidocaine on rapid recovery of laparoscopic cholecystectomy. Methods: This study was a prospective randomized controlled trial. From February to August 2016 in Affiliated Yiwu Hospital of Wenzhou Medical University, 60 patients scheduled for laparoscopic cholecystectomy under general anesthesia were involved and randomly divided into control group (n=30) and lidocaine group (n=30). Patients in lidocaine group received lidocaine 1.5 mg/kg intravenously before induction and followed by 2...
March 28, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28345961/the-short-term-efficacy-of-an-unguided-internet-based-cognitive-behavioral-therapy-for-insomnia-a-randomized-controlled-trial-with-a-six-month-nonrandomized-follow-up
#9
Susanne Hagatun, Øystein Vedaa, Tine Nordgreen, Otto R F Smith, Ståle Pallesen, Odd E Havik, Bjørn Bjorvatn, Frances P Thorndike, Lee M Ritterband, Børge Sivertsen
OBJECTIVE: Insomnia is a major health problem, and the need for effective and accessible treatment is urgent. The aim of the current study was to evaluate the short-term efficacy of an unguided Internet-based cognitive-behavioral treatment program for insomnia (CBTi), called SHUTi (Sleep Healthy Using the Internet). METHODS: This study used a parallel arm randomized controlled trial in Norway. Participants were randomly allocated to the SHUTi condition or a Web-based patient education condition...
March 27, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28338061/heteroleptic-copper-i-complexes-of-scorpionate-bis-pyrazolyl-carboxylate-ligand-with-auxiliary-phosphine-as-potential-anticancer-agents-an-insight-into-cytotoxic-mode
#10
Rais Ahmad Khan, Mohammad Usman, Rajakumar Dhivya, Perumalsamy Balaji, Ali Alsalme, Hamad AlLohedan, Farukh Arjmand, Khalid AlFarhan, Mohammad Abdulkader Akbarsha, Fabio Marchetti, Claudio Pettinari, Sartaj Tabassum
New copper(I) complexes [CuCl(PPh3)(L)] (1: L = LA = 4-carboxyphenyl)bis(3,5-dimethylpyrazolyl)methane; (2: L = LB = 3-carboxyphenyl)bis(3,5-dimethylpyrazolyl)methane) were prepared and characterised by elemental analysis and various spectroscopic techniques such as FT-IR, NMR, UV-Vis, and ESI-MS. The molecular structures of complexes 1 and 2 were analyzed by theoretical B3LYP/DFT method. Furthermore, in vitro DNA binding studies were carried out to check the ability of complexes 1 and 2 to interact with native calf thymus DNA (CT-DNA) using absorption titration, fluorescence quenching and circular dichroism, which is indicative of more avid binding of the complex 1...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28298244/frailty-related-to-anesthesia-guided-by-the-index-bispectral-frail-study-study-protocol-for-a-randomized-controlled-trial
#11
Morgan Le Guen, Marie Herr, Antoine Bizard, Caroline Bichon, Nathalie Boichut, Thierry Chazot, Ngai Liu, Joel Ankri, Marc Fischler
BACKGROUND: Currently, patients older than 60 years of age represent 25% of the population and are at an increased risk during surgery. Therefore, reducing postoperative morbidity and mortality is a major concern in medical research and practice. Dependence on caregivers and cognitive impairment represent two major risk factors in the elderly, especially in frail patients after surgery under general anesthesia. In this context, continuous monitoring of the depth of anesthesia using a bispectral index (BIS) sensor may reduce the occurrence of impairments by gaining better control of the anesthetic depth...
March 16, 2017: Trials
https://www.readbyqxmd.com/read/28282136/mechanistic-investigation-of-bis-imino-pyridine-manganese-catalyzed-carbonyl-and-carboxylate-hydrosilylation
#12
Tufan K Mukhopadhyay, Christopher L Rock, Mannkyu Hong, Daniel C Ashley, Thomas L Groy, Mu-Hyun Baik, Ryan J Trovitch
We recently reported a bis(imino)pyridine (or pyridine diimine, PDI) manganese precatalyst, ((Ph2PPr)PDI)Mn (1), that is active for the hydrosilylation of ketones and dihydrosilylation of esters. In this contribution, we reveal an expanded scope for 1-mediated hydrosilylation and propose two different mechanisms through which catalysis is achieved. Aldehyde hydrosilylation turnover frequencies (TOFs) of up to 4900 min(-1) have been realized, the highest reported for first row metal-catalyzed carbonyl hydrosilylation...
March 27, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28272202/effects-of-combined-epidural-and-general-anesthesia-on-intraoperative-hemodynamic-responses-postoperative-cellular-immunity-and-prognosis-in-patients-with-gallbladder-cancer-a-randomized-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
Jun Zhu, Xue-Rong Zhang, Hu Yang
BACKGROUND: This study is supposed to investigate the effects of combined epidural and general anesthesia on intraoperative hemodynamic responses, postoperative cellular immunity, and prognosis in patients with gallbladder cancer (GBC). METHODS: One hundred forty-four GBC patients were selected and randomly divided into the general anesthesia (GA) group and the combined epidural-general anesthesia (CEGA) group. Before anesthesia induction (t0), at intubation (t1), at the beginning of surgery (t2), 5 minutes after pneumoperitoneum (t3), at the end of surgery (t4), after recovery of spontaneous breathing (t5), after regaining consciousness (t6), and after extubation (t7), the heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and the depth of anesthesia (bispectral index [BIS]) were detected...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28254462/fatty-acid-amide-hydrolase-inhibitor-treatment-in-men-with-chronic-prostatitis-chronic-pelvic-pain-syndrome-an-adaptive-double-blind-randomized-controlled-trial
#14
Florian M E Wagenlehner, J W Olivier van Till, Jos G A Houbiers, Reynaldo V Martina, Dirk P Cerneus, Joost H J M Melis, Antoni Majek, Egils Vjaters, Michael Urban, Henrikas Ramonas, Daniel A Shoskes, J Curtis Nickel
OBJECTIVE: To examine the effect of a peripherally active fatty acid amide hydrolase (FAAH) inhibitor ASP3652 on safety and efficacy outcomes in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Inhibition of FAAH is hypothesized to reduce the excitability of urinary tract afferents including nociceptors. MATERIALS AND METHODS: In this adaptive, randomized, double-blind, placebo-controlled study, adult male patients with moderate to severe CP/CPPS were treated for 12 weeks with an oral dose of ASP3652 (25, 75, 150, or 300 mg twice daily, or 300 mg once daily), or placebo...
February 27, 2017: Urology
https://www.readbyqxmd.com/read/28246456/nutrigenomic-evaluation-of-garlic-allium-sativum-and-holy-basil-ocimum-sanctum-leaf-powder-supplementation-on-growth-performance-and-immune-characteristics-in-broilers
#15
N Sheoran, R Kumar, A Kumar, K Batra, S Sihag, S Maan, N S Maan
AIM: In this study, a planned research work was conducted to investigate the nutrigenomic aspects of supplementation of Allium sativum (garlic) and Ocimum sanctum (holy basil) leaf powder on the growth performance and immune characteristics of broilers. MATERIALS AND METHODS: A 6 weeks feeding trial was conducted with 280-day-old Ven Cobb broilers, distributed randomly into seven experimental groups. Each treatment had 4 replicates with 10 birds each. The birds of the control group (T1) were fed a basal diet formulated as per BIS standards...
January 2017: Veterinary World
https://www.readbyqxmd.com/read/28243855/optimal-propofol-induction-dose-in-morbidly-obese-patients-a-randomized-controlled-trial-comparing-the-bispectral-index-and-lean-body-weight-scalar
#16
Yamini Subramani, Waleed Riad, Frances Chung, Jean Wong
PURPOSE: Propofol dosing based on total body weight (TBW) can lead to overdosing in morbidly obese (MO) patients. Our aim was to determine whether an induction dose of propofol based on a bispectral index (BIS) target is better for achieving loss of consciousness in MO patients than dosing based on lean body weight (LBW). METHODS: Sixty MO patients with a body mass index (BMI) of ≥ 40 kg·m(-2) were randomized to either BIS- or LBW-based propofol dosing groups...
February 27, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28178175/the-effect-of-nicardipine-on-the-surgical-pleth-index-during-thyroidectomy-under-general-anesthesia-a-prospective-double-blind-randomized-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Young Ju Won, Byung Gun Lim, Gwi Eun Yeo, Min Ki Lee, Dong Kyu Lee, Heezoo Kim, Il Ok Lee, Myoung Hoon Kong
BACKGROUND: The effectiveness of surgical pleth index (SPI) for managing nociception-antinociception balance during general anesthesia with vasodilators, including nicardipine has not been demonstrated. We aimed to compare the time course during surgery in SPI values in patients receiving nicardipine or remifentanil infusion during thyroidectomy. METHODS: Forty patients undergoing thyroidectomy were randomly assigned to receive nicardipine (group N; n = 19) or remifentanil (group R; n = 21) along with induction (propofol, fentanyl, and rocuronium) and maintenance (50% desflurane/nitrous oxide in oxygen) anesthesia (goal bispectral index [BIS] ∼50)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28159731/a-prospective-multicenter-single-blind-study-assessing-indices-of-snap-ii-versus-bis-vista-on-surgical-patients-undergoing-general-anesthesia
#18
Sergio D Bergese, Alberto A Uribe, Erika G Puente, R-Jay L Marcus, Randall J Krohn, Steven Docsa, Roy G Soto, Keith A Candiotti
BACKGROUND: Traditionally, anesthesiologists have relied on nonspecific subjective and objective physical signs to assess patients' comfort level and depth of anesthesia. Commercial development of electrical monitors, which use low- and high-frequency electroencephalogram (EEG) signals, have been developed to enhance the assessment of patients' level of consciousness. Multiple studies have shown that monitoring patients' consciousness levels can help in reducing drug consumption, anesthesia-related adverse events, and recovery time...
February 3, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28132007/ibobbly-mobile-health-intervention-for-suicide-prevention-in-australian-indigenous-youth-a-pilot-randomised-controlled-trial
#19
Joseph Tighe, Fiona Shand, Rebecca Ridani, Andrew Mackinnon, Nicole De La Mata, Helen Christensen
OBJECTIVES: Rates of youth suicide in Australian Indigenous communities are 4 times the national youth average and demand innovative interventions. Historical and persistent disadvantage is coupled with multiple barriers to help seeking. Mobile phone applications offer the opportunity to deliver therapeutic interventions directly to individuals in remote communities. The pilot study aimed to evaluate the effectiveness of a self-help mobile app (ibobbly) targeting suicidal ideation, depression, psychological distress and impulsivity among Indigenous youth in remote Australia...
January 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28127808/a-randomized-controlled-trial-of-brief-interventions-to-reduce-drug-use-among-adults-in-a-low-income-urban-emergency-department-the-healthier-you-study
#20
Frederic C Blow, Maureen A Walton, Amy S B Bohnert, Rosalinda V Ignacio, Stephen Chermack, Rebecca M Cunningham, Brenda M Booth, Mark Ilgen, Kristen L Barry
AIMS: To examine efficacy of drug brief interventions (BIs) among adults presenting to a low income urban emergency department (ED). DESIGN: Randomized controlled trial on drug use outcomes at 3-, 6-, and 12-months. Participants were assigned to 1) computer-delivered BI (Computer BI), 2) therapist-delivered, computer-guided BI (Therapist BI), or 3) enhanced usual care (EUC-ED) for drug-using adults. Participants were re-randomized after the 3-month assessment to either adapted motivational enhancement therapy (AMET) booster; or enhanced usual care booster (EUC-B)...
January 26, 2017: Addiction
keyword
keyword
66736
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"