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https://www.readbyqxmd.com/read/29657696/comparing-effectiveness-of-mindfulness-based-relapse-prevention-with-treatment-as-usual-on-impulsivity-and-relapse-for-methadone-treated-patients-a-randomized-clinical-trial
#1
Mehdi Yaghubi, Fatemeh Zargar, Hossein Akbari
Background: Impulsivity is one of the causes of relapse that can affect treatment outcomes. Studies have shown that addiction treatments can reduce impulsivity in drug-dependent individuals. Studies also have suggested that mindfulness is associated with impulsivity. However, no study has investigated the effectiveness of the mindfulness-based intervention on impulsivity in opioid-dependent individuals. This study aimed to compare the effectiveness of mindfulness-based relapse prevention (MBRP) with treatment as usual (TAU) in terms of impulsivity and relapse for methadone-treated patients...
July 2017: Addiction & Health
https://www.readbyqxmd.com/read/29584464/endophyte-enhanced-phytoremediation-of-dde-contaminated-using-cucurbita-pepo-a-field-trial
#2
N Eevers, J R Hawthorne, J C White, J Vangronsveld, N Weyens
Although the use of the pesticide 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDT) was banned from the mid-1970s, its most abundant and recalcitrant degradation product, 2,2-bis(p-chlorophenyl)-1,1-dichloro-ethylene (DDE), is still present in terrestrial and aquatic ecosystems worldwide. Zucchini (Cucurbita pepo ssp. pepo) has been shown to accumulate high concentrations of DDE and was proposed for phytoremediation of contaminated soils. We performed a field trial covering a full plant life cycle. C. pepo plants inoculated with the plant growth-promoting endophytic strains Sphingomonas taxi UH1, Methylobacterium radiotolerans UH1, Enterobacter aerogenes UH1, or a consortium combining these 3 strains were grown on a DDE-contaminated field for 100 days...
March 21, 2018: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/29582946/-effects-of-cannabis-extract-premedication-on-anesthetic-depth
#3
Carlos Ibera, Ben Shalom, Fayez Saifi, Joshua Shruder, Elyad Davidson
BACKGROUND: Cannabis is the most widely used illicit drug in the world, used by approximately 2.7-4.9% of the world's population, and 7.6-10.2% of Israel's adults. During the past few years, legal systems around the world have enacted large scale adoption of the legalization of both medical and recreational cannabis. Anesthetists should therefore be prepared to treat patients who used cannabis and are undergoing elective or emergency operations. However, the interactions between cannabinoids and general anesthetic agents and the possible implications for patient care are not yet fully understood...
March 2018: Harefuah
https://www.readbyqxmd.com/read/29514524/randomised-comparison-of-silicone-gel-and-onion-extract-gel-for-post-surgical-scars
#4
Taejong Song, Kye Hyun Kim, Kyo Won Lee
To compare the efficacy of silicone gel and onion extract gel on new surgical wounds, we performed a randomised controlled trial evaluating the appearance of the laparoscopic surgical scars of 60 subjects after 12 weeks of two times daily application of either silicone gel or onion extract gel. Objective scar assessment by the Vancouver Scar Scale (VSS) and the Image Panel Scale (IPS) and subjective scar assessment by the Body Image Scale (BIS) and Cosmetic Scale (CS) were performed after 12 weeks of treatment...
March 7, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29484267/pocd-in-patients-receiving-total-knee-replacement-under-deep-vs-light-anesthesia-a-randomized-controlled-trial
#5
Ruixue Hou, Hong Wang, Lianhua Chen, Yimin Qiu, Shitong Li
Objectives: Clinical observation, as well as randomized controlled trials, indicated an increasing rate of postoperative cognitive dysfunction (POCD) with increasing depth of general anesthesia. However, the findings are subject to bias due to varying degree of analgesia. In this trial, we compared the rate of POCD between patients receiving light versus high anesthesia while holding analgesia comparable using nerve block. Methods: Elderly patients (≧60 years) receiving elective total knee replacement were randomized to receive the surgery under general anesthesia at BIS 40-50 (LOBIS group) or BIS 55-65 (HIBIS group)...
February 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29481560/failure-of-fluconazole-in-treating-cutaneous-leishmaniasis-caused-by-leishmania-guyanensis-in-the-brazilian-amazon-an-open-nonrandomized-phase-2-trial
#6
Valeska Albuquerque Francesconi, Fabio Francesconi, Rajendranath Ramasawmy, Gustavo Adolfo Sierra Romero, Maria das Graças Costa Alecrim
BACKGROUND: The treatment of Leishmaniasis caused by Leishmania (Viannia) guyanensis is based on a weak strength of evidence from very few clinical trials and some case series reports. Current treatment guidelines recommend pentamidine isethionate or meglumine antimoniate (Glucantime) as the first-line choices. Both are parenteral drugs with a low therapeutic indexes leading to a high risk of undesired effects. Imidazole derivatives interfere with the production of leishmanial ergosterol, an essential component of their membrane structure...
February 26, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29464690/bis-monitoring-versus-clinical-assessment-for-sedation-in-mechanically-ventilated-adults-in-the-intensive-care-unit-and-its-impact-on-clinical-outcomes-and-resource-utilization
#7
REVIEW
Rajesh M Shetty, Antonio Bellini, Dhuleep S Wijayatilake, Mark A Hamilton, Rajesh Jain, Sunil Karanth, ArunKumar Namachivayam
BACKGROUND: Patients admitted to intensive care and on mechanical ventilation, are administered sedative and analgesic drugs to improve both their comfort and interaction with the ventilator. Optimizing sedation practice may reduce mortality, improve patient comfort and reduce cost. Current practice is to use scales or scores to assess depth of sedation based on clinical criteria such as consciousness, understanding and response to commands. However these are perceived as subjective assessment tools...
February 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29464504/significant-and-safe-reduction-of-propofol-sedation-dose-for-geriatric-population-undergoing-pacemaker-implantation-randomized-clinical-trial
#8
Ana Luisa Hernandez-Perez, Ana Gabriela Gallardo-Hernandez, German Ordoñez-Espinosa, Beatriz Martinez-Carrillo, Manuel Gerardo Bermudez-Ochoa, Cristina Revilla-Monsalve, Jose Antonio Sanchez-Lopez, Guillemo Saturno-Chiu, Ronald Leder
OBJECTIVE: A previous multidisciplinary pilot study based on computer simulations for the geriatric population showed that a dose of 0.5 mg/kg/h of propofol could sedate patients older than 65 for pacemaker implantation. The present study validates that the pacemaker implantation can be done in the elderly using 0.5-1 mg/kg/h of propofol with hemodynamic stability. METHODS: 66 patients from 65 to 88 years old scheduled for pacemaker implantation were randomly assigned one of three doses of propofol...
February 21, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29433385/intravenous-lidocaine-as-adjuvant-to-general-anesthesia-in-renal-surgery
#9
Mohamed Said Nakhli, Mohamed Kahloul, Taieb Guizani, Chekib Zedini, Ajmi Chaouch, Walid Naija
The role of intraoperative intravenous lidocaine infusion has been previously evaluated for pain relief, inflammatory response, and post-operative recovery, particularly in abdominal surgery. The present study is a randomized double-blinded trial in which we evaluated whether IV lidocaine infusion reduces isoflurane requirement, intraoperative remifentanil consumption and time to post-operative recovery in non-laparoscopic renal surgery. Sixty patients scheduled to undergo elective non-laparoscopic renal surgery under general anesthesia were enrolled to receive either systemic lidocaine infusion (group L: bolus 1...
December 2018: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/29404979/nrg-oncology-rtog-9006-a-phase-iii-randomized-trial-of-hyperfractionated-radiotherapy-rt-and-bcnu-versus-standard-rt-and-bcnu-for-malignant-glioma-patients
#10
Arif N Ali, Peixin Zhang, W K Alfred Yung, Yuhchyau Chen, Benjamin Movsas, Raul C Urtasun, Christopher U Jones, Kwang N Choi, Jeff M Michalski, A Jennifer Fischbach, Arnold M Markoe, Christopher J Schultz, Marta Penas-Prado, Madhur K Garg, Alan C Hartford, Harold E Kim, Minhee Won, Walter J Curran
From 1990 to 1994, patients with newly diagnosed malignant gliomas were enrolled and randomized between hyperfractionated radiation (HFX) of 72.0 Gy in 60 fractions given twice daily and 60.0 Gy in 30 fractions given once daily. All patients received 80 mg/m2 of 1,3 bis(2 chloroethyl)-1 nitrosourea on days 1-3 q8 weeks for 1 year. Patients were stratified by age, KPS, and histology. The primary endpoint was overall survival (OS), with secondary endpoints including progression-free survival (PFS) and toxicity...
March 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29397214/efficacy-of-articaine-versus-lidocaine-in-supplemental-infiltration-for-mandibular-first-versus-second-molars-with-irreversible-pulpitis-a-prospective-randomized-double-blind-clinical-trial
#11
Michael R Shapiro, Neville J McDonald, Richard J Gardner, Mathilde C Peters, Tatiana M Botero
INTRODUCTION: Profound pulpal anesthesia is difficult to achieve in mandibular molars with irreversible pulpitis (IP). However, there are no published randomized controlled clinical trials comparing the success of supplemental buccal infiltration (BI) in mandibular first versus second molars with IP. The purpose of this prospective, randomized, double-blind study was to compare the efficacy of 4% articaine with 2% lidocaine for supplemental BIs in mandibular first versus second molars with IP after a failed inferior alveolar nerve block (IANB)...
April 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29386302/does-routine-bioimpedance-guided-fluid-management-provide-additional-benefit-to-non-anuric-peritoneal-dialysis-patients-results-from-compass-clinical-trial
#12
Kook-Hwan Oh, Seon Ha Baek, Kwon-Wook Joo, Dong Ki Kim, Yon-Su Kim, Sejoong Kim, Yun Kyu Oh, Byoung Geun Han, Jae Hyun Chang, Wookyung Chung, Ki Young Na
INTRODUCTION: In peritoneal dialysis (PD) patients, volume overload is related to cardiac dysfunction and mortality, while intravascular volume depletion is associated with a rapid decline in the residual renal function (RRF). This study sought to determine the clinical usefulness of bioimpedance spectroscopy (BIS)-guided fluid management for preserving RRF and cardiac function in PD patients. SUBJECTS AND METHODS: This is a multicenter, prospective, open-label study that was conducted over a 1-year period (NCT01887262)...
January 31, 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29353681/the-error-related-negativity-ern-is-an-electrophysiological-marker-of-motor-impulsiveness-on-the-barratt-impulsiveness-scale-bis-11-during-adolescence
#13
Jasmine B Taylor, Troy A W Visser, Simone N Fueggle, Mark A Bellgrove, Allison M Fox
OBJECTIVES: Previous studies have postulated that the error-related negativity (ERN) may reflect individual differences in impulsivity; however, none have used a longitudinal framework or evaluated impulsivity as a multidimensional construct. The current study evaluated whether ERN amplitude, measured in childhood and adolescence, is predictive of impulsiveness during adolescence. METHODS: Seventy-five children participated in this study, initially at ages 7-9 years and again at 12-18 years...
January 10, 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29332430/effect-of-creatine-phosphate-sodium-on-bispectral-index-and-recovery-quality-during-the-general-anaesthesia-emergence-period-in-elderly-patients-a-randomized-double-blind-placebo-controlled-trial
#14
Wei Wang, Wan-You Yu, Jie Lv, Lian-Hua Chen, Zhong Li
Objective To evaluate the effect of creatine phosphate sodium on bispectral index (BIS) and recovery quality during the general anaesthesia emergence period in elderly patients. Methods This randomized, double-blind, placebo-controlled study enrolled patients undergoing transabdominal cholecystectomy under general anaesthesia. Patients were randomly assigned to receive either creatine phosphate sodium (1.0 g/100 ml 0.9% saline; group P) or 100 ml 0.9% saline (group C) over 30 minutes during surgical incision...
March 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29313285/treatment-dosing-patterns-and-clinical-outcomes-for-patients-with-type-2-diabetes-starting-or-switching-to-treatment-with-insulin-glargine-300-units-per-milliliter-in-a-real-world-setting-a-retrospective-observational-study
#15
Shaloo Gupta, Hongwei Wang, Neil Skolnik, Liyue Tong, Ryan M Liebert, Lulu K Lee, Peter Stella, Anna Cali, Ronald Preblick
INTRODUCTION: Usage patterns and effectiveness of a longer-acting formulation of insulin glargine at a strength of 300 units per milliliter (Gla-300) have not been studied in real-world clinical practice. This study evaluated differences in dosing and clinical outcomes before and after Gla-300 treatment initiation in patients with type 2 diabetes starting or switching to treatment with Gla-300 to assess whether the benefits observed in clinical trials translate into real-world settings...
January 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29304735/effect-of-single-dose-dexmedetomidine-on-postoperative-recovery-after-ambulatory-ureteroscopy-and-ureteric-stenting-a-double-blind-randomized-controlled-study
#16
I I Shariffuddin, W H Teoh, S Wahab, C Y Wang
BACKGROUND: Ambulatory surgery has recently gain popularity, as it is a good method of optimizinghospital resources utilization. To support ambulatory surgery, anaesthetic goals nowrevolve around patients' early recovery with minimal pain and nausea, expedientdischarge home and prompt resumption of activities of daily living. In this study, weevaluated the effect of a single pre-induction dose of dexmedetomidine on anaestheticrequirements, postoperative pain and clinical recovery after ambulatory ureteroscopy andureteric stenting under general anaesthesia...
January 5, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29302857/combination-of-omega-3-fatty-acids-and-valproic-acid-in-treatment-of-borderline-personality-disorder-a-follow-up-study
#17
Paola Bozzatello, Paola Rocca, Silvio Bellino
BACKGROUND AND OBJECTIVES: Some evidence of efficacy has been found for omega-3 fatty acids in patients with borderline personality disorder (BPD). In a previous 12-week randomized trial we assessed the efficacy of the combination of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) with valproic acid, in comparison with valproic acid monotherapy, in 43 BPD outpatients. Combined therapy was superior to valproic acid monotherapy (the control group) in the treatment of some BPD symptoms: impulsive-behavioral dyscontrol, outbursts of anger, and self-harm...
April 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29291549/sexual-hiv-risk-behavior-outcomes-of-brief-interventions-for-drug-use-in-an-inner-city-emergency-department-secondary-outcomes-from-a-randomized-controlled-trial
#18
Erin E Bonar, Maureen A Walton, Kristen L Barry, Amy S B Bohnert, Stephen T Chermack, Rebecca M Cunningham, Lynn S Massey, Rosalinda V Ignacio, Frederic C Blow
BACKGROUND: Drug use is an established risk factor for HIV. Brief Interventions (BIs) targeting reductions in both drug use and HIV risk behaviors may help curtail these related epidemics. The present study evaluates the impact of BIs for drug use and HIV risk reduction on sexual HIV risk behaviors among a primarily marijuana-using sample during a 12-month post-intervention follow-up period. METHODS: We conducted a randomized controlled trial of 780 adult patients in an Emergency Department (ED) with past 3-month drug use (primarily non-injecting)...
February 1, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29284864/effect-of-intravenous-magnesium-sulfate-on-the-minimum-alveolar-concentrations-of-desflurane-using-bispectral-index-monitoring-a-prospective-randomized-double-blind-controlled-study
#19
Mohd Rameez Riaz, Vikram Mahajan, Sadaf Syed, Riyaz Ahmad
Background: Magnesium sulfate has been implicated to influence the minimum alveolar concentration (MAC) of various volatile anesthetics, but its effect on desflurane remains unanswered so far. Aim: To study the effect of perioperative intravenous magnesium sulfate on MAC of desflurane using bispectral index (BIS) monitoring. Settings: Operating room of a tertiary care hospital. Design: A prospective, randomized, controlled, double-blind clinical trial...
October 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29284847/evaluation-of-preoperative-flupirtine-in-ambulatory-functional-endoscopic-sinus-surgery-a-prospective-double-blind-randomized-controlled-trial
#20
Anjan Das, Hirak Biswas, Anindya Mukherjee, Sandip Roy Basunia, Subinay Chhaule, Tapobrata Mitra, Partha Sarathi Halder, Subrata Kumar Mandal
Background: Functional endoscopic sinus surgery (FESS) is the mainstay therapeutic management for nasal pathologies. We evaluated flupirtine, a centrally acting analgesic, for producing perfect perioperative conditions in FESS for adults in a day-care setting. Materials and Methods: Sixty-two patients (25-40 years) scheduled for FESS under general anesthesia were randomly divided into Group F ( n = 31) receiving preoperative flupirtine (100 mg) and Group C ( n = 31) receiving identical-looking placebo capsule per oral 60 min before induction of anesthesia...
October 2017: Anesthesia, Essays and Researches
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