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P W van Egmond, M C Vermeulen, C F van Dijke, H C A Graat
A 59-year-old woman with a painful right knee that became locked in extension after a trivial trauma was seen at the emergency room. This was caused by unloaded hyperextension in bed. She was diagnosed with a superior dislocation of the patella. A closed reduction was performed, but a recurrent episode was seen within a week. An arthroscopy was performed, in which the causative osteophytes were removed. In the 12-month follow-up after treatment, no recurrence was seen. A superior dislocation of the patella is caused by patellofemoral osteophytes that interlock...
December 3, 2016: Skeletal Radiology
Hamza Boukabache, Michel Pangallo, Gael Ducos, Nicola Cardines, Antonio Bellotta, Ciarán Toner, Daniel Perrin, Doris Forkel-Wirth
The European Organization for Nuclear Research (CERN) has the legal obligation to protect the public and the people working on its premises from any unjustified exposure to ionising radiation. In this context, radiation monitoring is one of the main concerns of the Radiation Protection Group. After 30 y of reliable service, the ARea CONtroller (ARCON) system is approaching the end of its lifecycle, which raises the need for new, more efficient radiation monitors with a high level of modularity to ensure better maintainability...
November 30, 2016: Radiation Protection Dosimetry
Eun-Seok Choi, Ilkyu Han, Hwan Seong Cho, In Woong Park, Jong Woong Park, Han-Soo Kim
BACKGROUND: Endoprosthetic reconstruction is widely applied for pathological fractures of the proximal humerus; however, functional impairment is usually unsatisfactory. The aims of the current study are to evaluate the reliability of interlocking intramedullary (IM) nailing with cement augmentation as a fixation method in proximal humeral lesions and to assess functional outcomes. METHODS: We reviewed 32 patients with pathological fractures of the proximal humerus who underwent interlocking IM nailing and cement augmentation...
December 2016: Clinics in Orthopedic Surgery
He-Lue Sun, Heng-Yi Zhang, Zhen Dai, Xu Han, Yu Liu
Rotaxane and pseudorotaxane are two sorts of different mechanically interlocked molecular architectures, and there is obvious topological difference and boundary between them. In this work, a "suggested [2]rotaxane 1α-CD" was constructed based on an axle molecule 1 bearing two terminal ferrocene groups and a wheel component α-cyclodextrin (α-CD), but the result obtained indicated that the ferrocene group cannot prevent α-CD dethreading under UV irradiation. That is, 1α-CD is just a pseudo[2]rotaxane...
November 29, 2016: Chemistry, An Asian Journal
G E Kim, A A Leme-Kraus, R Phansalkar, G Viana, C Wu, S-N Chen, G F Pauli, Akb Bedran-Russo
Secondary caries at the tooth-resin interface is the primary reason for replacement of resin composite restorations. The tooth-resin interface is formed by the interlocking of resin material with hydroxyapatite crystals in enamel and collagen mesh structure in dentin. Efforts to strengthen the tooth-resin interface have identified chemical agents with dentin collagen cross-linking potential and antimicrobial activities. The purpose of the present study was to assess protective effects of bioactive primer against secondary caries development around enamel and dentin margins of class V restorations, using an in vitro bacterial caries model...
November 28, 2016: Operative Dentistry
Priyanka Srinivasan, Mark A Miller, Nico Verdonschot, Kenneth A Mann, Dennis Janssen
Aseptic loosening of the tibial component remains the leading cause for revision surgery in total knee arthroplasty (TKA). Understanding the mechanisms leading to loss of fixation can offer insight into preventative measures to ensure a longer survival rate. In cemented TKA, loosening occurs at the cement-trabecular interface probably due to a stress-shielding effect of the stiffer implant material in comparison with bone. Using finite element models of lab-prepared tibial cement-trabeculae interface specimens (n=4) based on micro-CT images, this study aims to investigate the micromechanics of the interlock between cement and trabecular bone...
November 10, 2016: Journal of the Mechanical Behavior of Biomedical Materials
Parimala Narne, Vimal Pandey, Praveen Kumar Simhadri, Prakash Babu Phanithi
Neurodegeneration is a salient feature of chronic refractory brain disorders like Alzheimer's, Parkinson's, Huntington's, amyotropic lateral sclerosis and acute conditions like cerebral ischemia/reperfusion etc. The pathological protein aggregates, mitochondrial mutations or ischemic insults typifying these disease conditions collude with and intensify existing oxidative stress and attendant mitochondrial dysfunction. Interlocking these mechanisms is poly(ADP-ribose) polymerase (PARP-1) hyperactivation that invokes a distinct form of neuronal cell death viz...
November 17, 2016: Seminars in Cell & Developmental Biology
Seongmin Yuk, Min-Ju Choo, Dongyoung Lee, Hwanuk Guim, Tae-Ho Kim, Dai Gil Lee, Sungyu Choi, Dong-Hyun Lee, Gisu Doo, Young Taik Hong, Hee-Tak Kim
A scalable nanofastener featuring a 3D interlocked interfacial structure between the hydrocarbon membrane and perfluorinated sulfonic acid based catalyst layer is presented to overcome the interfacial issue of hydrocarbon membrane based polymer electrolyte membrane fuel cells. The nanofastener-introduced membrane electrode assembly (MEA) withstands more than 3000 humidity cycles which is 20 times higher durability than that of MEA without nanofastener.
November 10, 2016: Advanced Materials
Jernej Rus
In 2013 a novel self-assembly strategy for polypeptide nanostructure design which could lead to significant developments in biotechnology was presented in Gradišar et al. (Nat Chem Bio 9:362-366, 2013). It was since observed that a polyhedron P can be realized by interlocking pairs of polypeptide chains if its corresponding graph G(P) admits a strong trace. It was since also demonstrated that a similar strategy can also be expanded to self-assembly of designed DNA (Kočar, Nat commun 7:1-8, 2016). In this direction, in the present paper we characterize graphs which admit closed walk which traverses every edge exactly once in each direction and for every vertex v, there is no subset N of its neighbors, with [Formula: see text], such that every time the walk enters v from N, it also exits to a vertex in N...
November 16, 2016: Journal of Mathematical Biology
Ming Xu, Feng Du, Sabyasachi Ganguli, Ajit Roy, Liming Dai
Conventional adhesives show a decrease in the adhesion force with increasing temperature due to thermally induced viscoelastic thinning and/or structural decomposition. Here, we report the counter-intuitive behaviour of carbon nanotube (CNT) dry adhesives that show a temperature-enhanced adhesion strength by over six-fold up to 143 N cm(-2) (4 mm × 4 mm), among the strongest pure CNT dry adhesives, over a temperature range from -196 to 1,000 °C. This unusual adhesion behaviour leads to temperature-enhanced electrical and thermal transports, enabling the CNT dry adhesive for efficient electrical and thermal management when being used as a conductive double-sided sticky tape...
November 16, 2016: Nature Communications
Fatih Küçükdurmaz, Necdet Sağlam, Tuhan Kurtulmuş, Fuat Akpınar
INTRODUCTION: The fractures around the supramalleolar region are difficult to manage and deformities may occur following insufficient or inadequate treatment attempts. The treatment of those deformities is even more challenging. The available options for surgical fixation have inherent problems considering the soft tissue problems, infection and compliance of the patients. In this study, we report the preliminary outcome of new IMN system in use of supramalleolar deformities. PATIENTS AND METHODS: Three patients with supramalleolar deformities were recruited for this study...
November 11, 2016: Acta Orthopaedica et Traumatologica Turcica
Tetsuya Gotoh, Jae Kyoung Kim, Jingjing Liu, Marian Vila-Caballer, Philip E Stauffer, John J Tyson, Carla V Finkielstein
The circadian clock and cell cycle networks are interlocked on the molecular level, with the core clock loop exerting a multilevel regulatory role over cell cycle components. This is particularly relevant to the circadian factor Period 2 (Per2), which modulates the stability of the tumor suppressor p53 in unstressed cells and transcriptional activity in response to genotoxic stress. Per2 binding prevents Mdm2-mediated ubiquitination of p53 and, therefore, its degradation, and oscillations in the peaks of Per2 and p53 were expected to correspond...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
Xiaojie Huang, Xinchao Liu, Kathrine Meyers, Lihong Liu, Bin Su, Pengfei Wang, Zhen Li, Lan Li, Tong Zhang, Ning Li, Hui Chen, Haiying Li, Hao Wu
The timing, intensity and duration of the cytokine cascade and reorganized interrelations in cytokine networks are not fully understood during acute HIV-1 infection (AHI). Using sequential plasma samples collected over three years post-infection in a cohort of MSM HIV-1 seroconvertors, we determined the early kinetics of cytokine levels during FiebigI-IV stages using Luminex-based multiplex assays. Cytokines were quantified and relationships between cytokines were assessed by Spearman correlation. Compared with HIV-negative MSM, HIV-infected individuals had significantly increased multiple plasma cytokines, including GM-CSF, IFN-α2, IL-12p70, IP-10 and VEGF, during both acute and chronic stages of infection...
November 10, 2016: Scientific Reports
Karina R Silva, Rodrigo A Rezende, Frederico D A S Pereira, Peter Gruber, Mellannie P Stuart, Aleksandr Ovsianikov, Ken Brakke, Vladimir Kasyanov, Jorge V L da Silva, José M Granjeiro, Leandra S Baptista, Vladimir Mironov
Adipose stem cells (ASCs) spheroids show enhanced regenerative effects compared to single cells. Also, spheroids have been recently introduced as building blocks in directed self-assembly strategy. Recent efforts aim to improve long-term cell retention and integration by the use of microencapsulation delivery systems that can rapidly integrate in the implantation site. Interlockable solid synthetic microscaffolds, so called lockyballs, were recently designed with hooks and loops to enhance cell retention and integration at the implantation site as well as to support spheroids aggregation after transplantation...
2016: PloS One
Sharali Malik, Yoshihiro Nemoto, Hongxuan Guo, Katsuhiko Ariga, Jonathan P Hill
Carbon nanotubes (CNTs) have atomically smooth surfaces and tend not to form covalent bonds with composite matrix materials. Thus, it is the magnitude of the CNT/fiber interfacial strength that limits the amount of nanomechanical interlocking when using conventional CNTs to improve the structural behavior of composite materials through reinforcement. This arises from two well-known, long standing problems in this research field: (a) inhomogeneous dispersion of the filler, which can lead to aggregation and (b) insufficient reinforcement arising from bonding interactions between the filler and the matrix...
2016: Beilstein Journal of Nanotechnology
James E M Lewis, Marzia Galli, Stephen M Goldup
Mechanically interlocked molecules have a long and rich history as ligands thanks to the key role coordination chemistry has played in the development of high yielding passive template syntheses of rotaxanes and catenanes. In this Feature Article, we highlight the effect of the mechanical bond on the properties of metal ions bound within the sterically hindered environment of the macrocycle cavity, and discuss the emerging applications of interlocked ligands in catalysis, sensing and supramolecular materials...
November 7, 2016: Chemical Communications: Chem Comm
Yoichiro Ito, Xiaofeng Ma, Robert Clary
A simple tool is introduced which can modify the shape of tubing to enhance the partition efficiency in high-speed countercurrent chromatography. It consists of a pair of interlocking identical gears, each coaxially holding a pressing wheel to intermittently compress plastic tubing in 0 - 10 mm length at every 1 cm interval. The performance of the processed tubing is examined in protein separation with 1.6 mm ID PTFE tubing intermittently pressed in 3 mm and 10 mm width both at 10 mm intervals at various flow rates and revolution speeds...
2016: Current Chromatography
Kevin Jeanne Dit Fouque, Hélène Lavanant, Séverine Zirah, Julian D Hegemann, Marcel Zimmermann, Mohamed A Marahiel, Sylvie Rebuffat, Carlos Afonso
Lasso peptides are characterized by a mechanically interlocked structure, where the C-terminal tail of the peptide is threaded and trapped within an N-terminal macrolactam ring. Their compact and stable structures have a significant impact on their biological and physical properties and make them highly interesting for drug development. Ion mobility - mass spectrometry (IM-MS) has shown to be effective to discriminate the lasso topology from their corresponding branched-cyclic topoisomers in which the C-terminal tail is unthreaded...
November 3, 2016: Journal of the American Society for Mass Spectrometry
H-P Sobotta, T Gösling
There are a number of case reports about women undergoing long-term bisphosphonate therapy who have suffered an atypical subtrochanteric or femoral shaft fracture due to an inadequate trauma.The present case reports on a patient who underwent a subtrochanteric femur fracture with the inserted AO femur interlocking nail.
November 3, 2016: Der Unfallchirurg
Zhiyuan Liu, Xiaotian Wang, Dianpeng Qi, Cai Xu, Jiancan Yu, Yaqing Liu, Ying Jiang, Bo Liedberg, Xiaodong Chen
High-adhesion stretchable electrodes are fabricated by utilizing a novel nanopile interlocking strategy. Nanopiles significantly enhance adhesion and redistribute the strain in the film, achieving high stretchability. The nanopile electrodes enable simultaneous monitoring of electromyography signals and mechanical deformations. This study opens up a new perspective of achieving stretchability and high adhesion for stretchable electronics.
November 3, 2016: Advanced Materials
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