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https://www.readbyqxmd.com/read/29343748/sac7-and-rho1-regulate-the-white-to-opaque-switching-in-candida-albicans
#1
Siwy Ling Yang, Guisheng Zeng, Fong Yee Chan, Yan-Ming Wang, Dongliang Yang, Yue Wang
Candida albicans cells homozygous at the mating-type locus stochastically undergo the white-to-opaque switching to become mating-competent. This switching is regulated by a core circuit of transcription factors organized through interlocking feedback loops around the master regulator Wor1. Although a range of distinct environmental cues is known to induce the switching, the pathways linking the external stimuli to the central control mechanism remains largely unknown. By screening a C. albicans haploid gene-deletion library, we found that SAC7 encoding a GTPase-activating protein of Rho1 is required for the white-to-opaque switching...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29338177/a-novel-alkali-activation-of-titanium-substrates-to-grow-thick-and-covalently-bound-pmma-layers
#2
Melania Reggente, Patrick Masson, Camille Dollinger, Heinz Palkowski, Spyridon Zafeiratos, Leandro Jacomine, Daniele Passeri, Marco Rossi, Nihal Engin Vrana, Genevieve Pourroy, Adele Carrado
Titanium (Ti) is the most widely used metal in biomedical applications due to its biocompatibility; however, the significant difference of the mechanical properties between Ti and the surrounding tissues results in stress shielding which is detrimental for load bearing tissues. In the current study, to attenuate the stress shielding effect, a new processing route was developed. It aimed at growing thick poly(methyl methacrylate) (PMMA) layers grafted on Ti substrates to incorporate a polymer component on Ti implants...
January 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29337535/anion-mediated-photophysical-behavior-in-a-c60-fullerene-3-rotaxane-shuttle
#3
Timothy A Barendt, Ilija Rašović, Maria A Lebedeva, George A Farrow, Alexander Auty, Dimitri Chekulaev, Igor V Sazanovich, Julia A Weinstein, Kyriakos Porfyrakis, Paul D Beer
By addressing the challenge of controlling molecular motion, mechanically interlocked molecular machines are primed for a variety of applications in the field of nanotechnology. Specifically, the designed manipulation of communication pathways between electron donor and acceptor moieties that are strategically integrated into dynamic photoactive rotaxanes and catenanes may lead to efficient artificial photosynthetic devices. In this pursuit, a novel [3]rotaxane molecular shuttle consisting of a four station bis-naphthalene diimide (NDI) and central C60 fullerene bis-triazolium axle component and two mechanically bonded ferrocenyl functionalized -isophthalamide anion binding site-containing macrocycles is constructed using an anion template synthetic methodology...
January 16, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29335510/tio2-nanoribbons-carbon-nanotubes-composite-with-enhanced-photocatalytic-activity-fabrication-characterization-and-application
#4
Mohamed Shaban, Abdallah M Ashraf, Mostafa R Abukhadra
TiO2 nanoribbons (TiO2 NRs) loaded with FeCo-Al2O3 catalyst were synthesized and used as a precursor in the synthesis of TiO2 nanoribbons/carbon nanotubes (TiO2 NRs/CNTs) composite by a chemical vapor deposition (CVD) method. TiO2 NRs and TiO2 NRs/CNTs composite were characterized by XRD, FT-IR, TEM, SEM, EDX and UV-Vis spectrophotometer. The results revealed the formation of TiO2-B and hydrogen titanate nanoribbon like structures by the hydrothermal treatment. After loading TiO2 NRs by FeCo-Al2O3 catalyst and the CVD growth of carbon nanotubes, the synthetic TiO2 nanoribbons converted entirely to TiO2-B nanoribbons with nanopits structure...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29326763/incidence-of-varus-malalignment-post-interlocking-nail-in-proximal-femur-shaft-fractures-comparing-two-types-of-entry-points
#5
A N Sadagatullah, M N Nazeeb, S Ibrahim
Introduction: Osteosynthesis of the femur using an interlocking nail is the gold standard for treating diaphyseal fractures of the femur. There are two established entry points for the antegrade interlocking nails which is the piriformis fossa or the greater trochanter. It has been reported that varus malalignment was frequently seen in proximal femur fracture which were treated with interlocking nail utilizing the greater trochanter entry point. The study was done to find out if the problem was of significance...
November 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29319162/a-long-lived-a%C3%AE-oligomer-resistant-to-fibrillization
#6
Mimi Nick, Yibing Wu, Nathan W Schmidt, Stanley B Prusiner, Jan Stöhr, William F DeGrado
The hydrophobic Aβ peptide is highly aggregation prone; it first forms soluble oligomers, which then convert into the amyloid fibrils found in the cerebral plaques of Alzheimer's disease. It is generally understood that as the peptide concentration of Aβ increases, the fibrillization process is accelerated, but we examine the limits on this phenomenon. We found that once a threshold concentration of Aβ is exceeded, a stable oligomer is formed at the expense of fibril formation. The suppression of fibril formation was observed by amyloid-binding dye Thioflavin T and solution nuclear magnetic resonance (NMR)...
January 10, 2018: Biopolymers
https://www.readbyqxmd.com/read/29318341/-dynamization-of-fracture-fixation-timing-and-methods
#7
REVIEW
L Claes
The dynamization of fracture fixation is a frequently used method to improve the fracture healing process; however, the term dynamization is used for different methods of altering the fixation of fractures during the bone healing process. The dynamization of intramedullary nail fixation by removing the interlocking screws is the most frequently applied method. This method can cause a telescopic movement between the nail and tubular bone that closes gaps in bony continuity and potentially compresses the fracture fragments...
January 9, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29311313/structure-of-the-c1r-c1s-interaction-of-the-c1-complex-of-complement-activation
#8
Jamal O M Almitairi, Umakhanth Venkatraman Girija, Christopher M Furze, Xanthe Simpson-Gray, Farah Badakshi, Jamie E Marshall, Wilhelm J Schwaeble, Daniel A Mitchell, Peter C E Moody, Russell Wallis
The multiprotein complex C1 initiates the classical pathway of complement activation on binding to antibody-antigen complexes, pathogen surfaces, apoptotic cells, and polyanionic structures. It is formed from the recognition subcomponent C1q and a tetramer of proteases C1r2C1s2 as a Ca2+-dependent complex. Here we have determined the structure of a complex between the CUB1-EGF-CUB2 fragments of C1r and C1s to reveal the C1r-C1s interaction that forms the core of C1. Both fragments are L-shaped and interlock to form a compact antiparallel heterodimer with a Ca2+ from each subcomponent at the interface...
January 8, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29303130/quadriceps-strength-and-anterior-knee-pain-following-tibia-intramedullary-nailing-any-clinical-relationship
#9
O Esan, A O Ojoawo, I C Ikem
INTRODUCTION: Anterior knee pain can be chronic sequelae of intramedullary nailing of the tibia. Several causes have been identified; no single reason can fully explain the occurrence. We, therefore, set out to find the rate of anterior knee pain in our practice and if any relationship exists between the anterior knee pain and extensor muscle strength. METHODOLOGY: A total of 72 knees in 36 patients with no prior history of knee pain, but had unilateral tibiofibular fracture, who had internal fixation with interlocking intramedullary nailing done and were followed up for at least 1 year were recruited into the study...
November 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29302752/the-role-of-the-circadian-clock-system-in-physiology
#10
REVIEW
Violetta Pilorz, Charlotte Helfrich-Förster, Henrik Oster
Life on earth is shaped by the 24-h rotation of our planet around its axes. To adapt behavior and physiology to the concurring profound but highly predictable changes, endogenous circadian clocks have evolved that drive 24-h rhythms in invertebrate and vertebrate species. At the molecular level, circadian clocks comprised a set of clock genes organized in a system of interlocked transcriptional-translational feedback loops. A ubiquitous network of cellular central and peripheral tissue clocks coordinates physiological functions along the day through activation of tissue-specific transcriptional programs...
January 4, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29286312/a-triple-mode-flexible-e-skin-sensor-interface-for-multi-purpose-wearable-applications
#11
Sung-Woo Kim, Youngoh Lee, Jonghwa Park, Seungmok Kim, Heeyoung Chae, Hyunhyub Ko, Jae Joon Kim
This study presents a flexible wireless electronic skin (e-skin) sensor system that includes a multi-functional sensor device, a triple-mode reconfigurable readout integrated circuit (ROIC), and a mobile monitoring interface. The e-skin device's multi-functionality is achieved by an interlocked micro-dome array structure that uses a polyvinylidene fluoride and reduced graphene oxide (PVDF/RGO) composite material that is inspired by the structure and functions of the human fingertip. For multi-functional implementation, the proposed triple-mode ROIC is reconfigured to support piezoelectric, piezoresistance, and pyroelectric interfaces through single-type e-skin sensor devices...
December 29, 2017: Sensors
https://www.readbyqxmd.com/read/29285989/synthesis-and-functionalization-of-chitosan-built-hydrogel-with-induced-hydrophilicity-for-extended-release-of-sparingly-soluble-drugs
#12
Faheem Ullah, Fatima Javed, Mbh Othman, Abbas Khan, Rukhsana Gul, Zulkifli Ahmad, Hazizan Md Akil
Addressing the functional biomaterials as next-generation therapeutics, chitosan and alginic acid were copolymerized in the form of chemically crosslinked interpenetrating networks (IPNs). The native hydrogel was functionalized via carbodiimide (EDC), catalyzed coupling of soft ligand (1,2-Ethylenediamine) and hard ligand (4-aminophenol) to replace -OH groups in alginic acid units for extended hydrogel- interfaces with the aqueous and sparingly soluble drug solutions. The chemical structure, Lower solution critical temperature (LCST ≈ 37...
December 29, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29278367/enhancement-of-the-laser-transmission-weldability-between-polyethylene-and-polyoxymethylene-by-plasma-surface-treatment
#13
Huixia Liu, Yingjie Jiang, Wensheng Tan, Xiao Wang
Due to their large compatibility difference, polyethylene (PE) and polyoxymethylene (POM) cannot be welded together by laser transmission welding. In this study, PE and POM are pretreated using plasma that significantly enhances their laser transmission welding strength. To understand the mechanism underlying the laser welding strength enhancement, surface modification is analyzed using contact angle measurements, atomic force microscopy (AFM), optical microscopy, and X-ray photoelectron spectroscopy (XPS)...
December 26, 2017: Materials
https://www.readbyqxmd.com/read/29258983/genetic-and-epigeneticregulations-of-mammalian-circadian-rhythms
#14
Min Yue, Yu Yang, Gai Li Guo, Xi Ming Qin
The circadian clocks are vital to many organisms for their survival and adaption to the surrounding environment. More and more people are interested in the circadian clock and related researches. One of the key characteristics of this endogenous clock is its periodicity. Mechanisms underlying the mammalian circadian rhythms with ~24 h periodicity involve interlocked transcriptional and translational feedback loops. The circadian clock system in mammals consists of hierarchical structures, with the suprachiasmatic nucleus (SCN) as the central pacemaker and peripheral oscillators in other organs...
December 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29250686/ovarian-strumal-carcinoid-case-report
#15
Delia Gabriela Ciobanu Apostol, Tudor Andrei BuŢureanu, Demetra Gabriela Socolov, Daniela Claudia Scripcaru, Oana LuminiŢa Rosin, Ludmila Lozneanu
Strumal carcinoid represents a rare form of ovarian teratoma, consisting of both thyroid tissue and carcinoid structures. The carcinoid component is a well-differentiated neuroendocrine tumor with excellent prognosis. Strumal carcinoid tumors are commonly found in peri-menopausal women who are not usually interested in preserving their fertility and who are thus open to radical surgical treatment. In this report, we present a 24-year-old, nulliparous patient with strumal carcinoid, confirmed by histopathology and a large panel of immunohistochemistry (IHC) markers, who wished to preserve her fertility...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29249205/attention-vigilance-and-visuospatial-function-in-hospitalized-elderly-medical-patients-relationship-to-delirium-syndromal-status-and-motor-subtype-profile
#16
Cara Daly, Maeve Leonard, Henry O'Connell, Olugbenga Williams, Fahad Awan, Chris Exton, Margaret O'Connor, Dimitrios Adamis, Colum P Dunne, Walter Cullen, David J Meagher
BACKGROUND: The early and effective detection of neurocognitive disorders poses a key diagnostic challenge. We examined performance on common cognitive bedside tests according to differing delirium syndromal status and clinical (motor) subtypes in hospitalized elderly medical inpatients. METHODS: A battery of nine bedside cognitive tests was performed on elderly medical inpatients with DSM-IV delirium, subsyndromal delirium (SSD), and no delirium (ND). Patients with delirium were compared according to clinical (motor) subtypes...
December 18, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29244737/investigation-of-flat-clinching-process-combined-with-material-forming-technology-for-aluminum-alloy
#17
Chao Chen, Shengdun Zhao, Xiaolan Han, Yongfei Wang, Xuzhe Zhao
In recent years, the use of aluminum alloy has tended to increase for building lightweight automobiles to reduce their automotive weight, which is helpful to save energy and protect the environment. In order to join aluminum alloy, a flat-clinching process combined with material forming technology was investigated to join aluminum alloy sheets using an experimental and a numerical method. Al1060 was chosen as the material of the sheet, and DEFORM-2D software was used to build the numerical model. After the numerical model was validated by the experimental results, the influences of punch diameter and holder force on the materials deforming behavior of the clinched joint were analyzed using the numerical model...
December 15, 2017: Materials
https://www.readbyqxmd.com/read/29244683/insufficiency-fracture-occurring-3-years-after-union-of-an-intertrochanteric-hip-fracture-a-case-report
#18
Byung-Ho Yoon, Sung Bae Park
CASE: We present a rare case of insufficiency fracture at the level of the distal interlocking screw following union of an intertrochanteric hip fracture. A 74-year-old woman reported chronic thigh pain for 1 month. She had a history of an osteoporotic stable intertrochanteric fracture that was successfully treated with a short intramedullary nail 3.5 years prior. However, after union, the neck-shaft angle of the femur changed from 125° to 117°. She had been on alendronic acid therapy to prevent a secondary osteoporotic fracture...
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29242802/resistant-non-union-of-humerus-after-intramedullary-nailing-treated-with-locking-compression-plate-with-bone-grafting-with-nail-in-situ-and-shoulder-spica-a-case-report
#19
Jagdeep Singh, Anoop Kalia, Kavin Khatri, Anshul Dahuja
Introduction: Humerus non-union is a challenging situation for the surgeon and devastating and morbid situation for the patient. Surgical approach to the humerus is demanding because of the complex neurovascular anatomy and especially when previous surgeries have been attempted. Case Report: We report a case of a young adult male who sustained a compound fracture of humerus shaft treated with intramedullary nailing followed by subsequent bone grafting and eventually landed up in non-union and was treated at our center by locking compression plate application with nail in situ with iliac crest autogenous bone graft followed by shoulder spica application...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29238387/the-tight-interlocked-rhythm-section-production-and-perception-of-synchronisation-in-jazz-trio-performance
#20
Alex Hofmann, Brian C Wesolowski, Werner Goebl
This study investigates the production and perception of timing, synchronisation and dynamics in jazz trio performances. In a production experiment, six trio combinations of one saxophonist, two bassists, and three drummers were recorded while they performed three popular jazz songs. Onset timing and dynamics of each performer were extracted and analysed. Results showed that the tempo was significantly influenced by the timing of the drummers and all performers showed higher temporal precision on the backbeats...
2017: Journal of New Music Research
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