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Obesity and Metabolic Syndrome

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https://www.readbyqxmd.com/read/28092931/the-criteria-of-metabolic-syndrome-and-national-health-checkup-and-education-system-in-japan
#1
Kazumasa Yamagishi, Hiroyasu Iso
Two major definitions of metabolic syndrome have been proposed. One focuses on accumulation of risk factors such as the American Heart Association (AHA) and National Heart, Lung and Blood Institute (NHLBI) criteria; and the other focuses on abdominal obesity such as the International Diabetes Federation (IDF) and Japanese criteria. The latter consider waist circumference as an obligatory component, whereas the former does not. In 2009, the IDF, NHLBI, AHA and the other organizations attempted to unify these criteria, and waist circumference is no longer an obligatory component...
January 6, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28092404/metformin-versus-myoinositol-which-is-better-in-obese-pcos-patients-a-randomized-controlled-crossover-study
#2
Valeria Tagliaferri, Daniela Romualdi, Valentina Immediata, Simona De Cicco, Christian Di Florio, Antonio Lanzone, Maurizio Guido
CONTEXT: due to the central role of metabolic abnormalities in the pathophysiology of PCOS, insulin sensitising agents have been proposed as a feasible treatment option. OBJECTIVE: to investigate which is the more effective between metformin and myoinositol on hormonal, clinical and metabolic parameters in obese patients with polycystic ovary syndrome (PCOS). STUDY DESIGN: crossover randomized-controlled study. PATIENTS: Thirty-four PCOS obese women (age: 25...
January 16, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28090342/-1-h-mrs-measured-ectopic-fat-in-liver-and-muscle-is-associated-with-the-metabolic-syndrome-in-danish-girls-but-not-in-boys-with-overweight-and-obesity
#3
A Nissen, C E Fonvig, E Chabanova, C Bøjsøe, C Trier, O Pedersen, T Hansen, H S Thomsen, J-C Holm
BACKGROUND: The metabolic syndrome (MetS) is a complication to overweight and obesity, which can be observed already in childhood. Ectopic lipid accumulation in muscle and liver has been shown to associate with the development of insulin resistance and dyslipidemia. Thus, the interaction between MetS and ectopic fat may offer clinical relevance. OBJECTIVES: To investigate the prevalence of MetS, or components hereof, and ectopic fat accumulation in liver and skeletal muscle tissue in children, as well as interactions between these...
December 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/28089681/steatorrhea-and-hyperoxaluria-in-severely-obese-patients-before-and-after-roux-en-y-gastric-bypass
#4
Amber M Moreland, Carol A Santa Ana, John R Asplin, Joseph A Kuhn, Ross P Holmes, Jason A Cole, Elizabeth A Odstrcil, Thomas G Van Dinter, Juan G Martinez, John S Fordtran
BACKGROUND: Hyperoxaluria after Roux-en-Y gastric bypass (RYGB) is generally attributed to fat malabsorption. If hyperoxaluria is indeed caused by fat malabsorption, magnitudes of hyperoxaluria and steatorrhea should correlate. Severely obese patients, prior to bypass, ingest excess dietary fat, which can produce hyperphagic steatorrhea. The primary objective of the study was to determine whether urine oxalate excretion correlates with elements of fat balance in severely obese patients before and after RYGB...
January 12, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28089571/normo-and-hyperandrogenic-women-with-polycystic-ovary-syndrome-exhibit-an-adverse-metabolic-profile-through-life
#5
Pekka Pinola, Katri Puukka, Terhi T Piltonen, Johanna Puurunen, Eszter Vanky, Inger Sundström-Poromaa, Elisabet Stener-Victorin, Angelica Lindén Hirschberg, Pernille Ravn, Marianne Skovsager Andersen, Dorte Glintborg, Jan Roar Mellembakken, Aimo Ruokonen, Juha S Tapanainen, Laure C Morin-Papunen
OBJECTIVE: To compare the metabolic profiles of normo- and hyperandrogenic women with polycystic ovary syndrome (PCOS) with those of control women at different ages during reproductive life. DESIGN: Case-control study. SETTING: Not applicable. PATIENT(S): In all, 1,550 women with normoandrogenic (n = 686) or hyperandrogenic (n = 842) PCOS and 447 control women were divided into three age groups: <30, 30-39, and >39 years)...
January 12, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28086850/the-prevalence-trend-of-metabolic-syndrome-and-its-components-and-risk-factors-in-korean-adults-results-from-the-korean-national-health-and-nutrition-examination-survey-2008-2013
#6
Binh Thang Tran, Bo Yoon Jeong, Jin-Kyoung Oh
BACKGROUND: Abnormalities in the clinical markers of metabolic syndrome (MS) are associated with the development of cardiovascular disease, type 2 diabetes mellitus, and some cancers. MS prevalence in Korea increased between the mid-1990s and mid-2000s; however, no data on the recent trends of MS prevalence are available. Thus, we aimed to investigate the prevalence of MS, the five components of MS, and the related risk factors in Korean adults by using recent data. METHODS: Data from the Korean National Health and Nutrition Examination Survey conducted between 2008 and 2013 were used...
January 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28081171/a-higher-proportion-of-metabolic-syndrome-in-chinese-subjects-with-sleep-disordered-breathing-a-case-control-study-based-on-electrocardiogram-derived-sleep-analysis
#7
Ping-Huei Tseng, Pei-Lin Lee, Wei-Chung Hsu, Yan Ma, Yi-Chia Lee, Han-Mo Chiu, Yi-Lwun Ho, Ming-Fong Chen, Ming-Shiang Wu, Chung-Kang Peng
OBJECTIVE: The prevalence of metabolic syndrome (MS) has increased rapidly in Taiwan and worldwide. We aim to determine the association between sleep-disordered breathing (SDB) and MS in a Chinese general population. METHODS: This case-control study recruited subjects who have undergone a prospective electrocardiogram-based cardiopulmonary coupling (CPC) sleep spectrogram as part of the periodic health check-ups at the National Taiwan University Hospital. Comprehensive anthropometrics, blood biochemistry, prevalence of MS and its individual components were compared with Bonferroni correction between 40 subjects with SDB, defined as the CPC-derived apnea-hypopnea index (CPC-AHI) >5 event/hour and 80 age- and sex-matched controls, defined as CPC-AHI <1 event/hour...
2017: PloS One
https://www.readbyqxmd.com/read/28078997/lipoprotein-a-and-cardiovascular-risk-the-show-must-go-on
#8
Niki Katsiki, Khalid Al-Rasadi, Dimitri P Mikhailidis
Lipoprotein (a) [Lp(a)] is an independent but moderate, predictor for coronary heart disease (CHD) prevalence and severity. Several established and emerging cardiovascular (CV) risk factors including age, gender, ethnicity, smoking, dyslipidemia, hypertension, obesity, type 2 diabetes mellitus, alcohol consumption, arterial stiffness and hyperuricemia have been linked to Lp(a) metabolism. Apart from CHD, Lp(a) has been also associated with non-cardiac vascular diseases and diseases associated with increased CV risk such as chronic kidney disease, metabolic syndrome, non-alcoholic fatty liver disease, erectile dysfunction, obstructive sleep apnea syndrome, inflammatory bowel diseases and human immunodeficiency virus infection...
January 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28078757/lamellar-events-related-to-insulin-like-growth-factor-1-receptor-signaling-in-two-models-relevant-to-endocrinopathic-laminitis
#9
H E Lane, T A Burns, O C Hegedus, M R Watts, P S Weber, K A Woltman, R J Geor, L J McCutcheon, S C Eades, L E Mathes, J K Belknap
BACKGROUND: Insulin dysregulation, obesity, and exposure to high-non structural carbohydrate (NSC) forage are risk factors for equine metabolic syndrome (EMS)-associated laminitis (EMSAL); high systemic insulin concentrations in EMSAL are proposed to induce cellular dysregulation in the digital lamellae through activation of the IGF-1 receptor. OBJECTIVES: To use a dietary challenge model (DCM) and a euglycemic hyperinsulinemic clamp (EHC) model to assess lamellar growth factor-related signaling...
January 11, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28077733/identification-of-potential-plasma-biomarkers-for-nonalcoholic-fatty-liver-disease-by-integrating-transcriptomics-and-proteomics-in-laying-hens
#10
Meng-Tsz Tsai, Yu-Jen Chen, Ching-Yi Chen, Mong-Hsun Tsai, Chia-Li Han, Yu-Ju Chen, Harry J Mersmann, Shih-Torng Ding
BACKGROUND: Prevalent worldwide obesity is associated with increased incidence of nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome. The identification of noninvasive biomarkers for NAFLD is of recent interest. Because primary de novo lipogenesis occurs in chicken liver as in human liver, adult chickens with age-associated steatosis resembling human NAFLD is an appealing animal model. OBJECTIVE: The objective of this study was to screen potential biomarkers in the chicken model for NAFLD by transcriptomic and proteomic analysis...
January 11, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28077341/irisin-and-oxytocin-as-predictors-of-metabolic-parameters-in-obese-children
#11
Ciğdem Binay, Cem Paketçi, Savaş Güzel, Nedim Samancı
OBJECTIVE: Irisin and oxytocin can affect energy homeostasis and have been proposed to play an important role in reducing obesity and diabetes. We aimed to determine the relationship between metabolic parameters (including irisin and oxytocin levels) and anthropometric parameters in obese children. METHODS: Ninety obese children (mean age, 13.85 ± 1.63 years) and 30 healthy controls (mean age, 14.32 ± 1.58 years) were enrolled in this study. Anthropometric and laboratory parameters (glucose, insulin, lipid, oxytocin, and irisin levels) were analysed...
January 12, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28077318/alcohol-microbiome-life-style-influence-alcohol-and-non-alcoholic-organ-damage
#12
REVIEW
Manuela G Neuman, Samuel W French, Samir Zakhari, Stefen Malnick, Helmut K Seitz, Lawrence B Cohen, Mikko Salaspuro, Andreea Voinea Griffin, Andrei Barasch, Irina A Kirpich, Paul G Thomes, Laura W Schrum, Terrence M Donohue, Kusum Kharbanda, Marcus Cruz, Mihai Opris
This paper is based upon the "8th Charles Lieber's Satellite Symposium" organized by Manuela G. Neuman at the Research Society on Alcoholism Annual Meeting, onJune 25, 2016 at New Orleans, Louisiana, USA. The integrative symposium investigated different aspects of alcohol-induced liver disease (ALD) as well as non-alcohol-induced liver disease (NAFLD) and possible repair. We revealedthe basic aspects of alcohol metabolism that may be responsible for the development of liver diseaseas well as the factors that determine the amount, frequency and which type of alcohol misuse leads to liver and gastrointestinal diseases...
January 7, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28076482/correlation-of-non-alcoholic-fatty-liver-disease-and-features-of-metabolic-syndrome-in-morbidly-obese-patients-in-the-preoperative-assessment-for-bariatric-surgery
#13
Fernando de Barros, Sergio Setúbal, José Manoel Martinho, Loraine Ferraz, Andressa Gaudêncio
Background: Obesity is an epidemic and chronic disease that can bring other comorbidities to the patient. Non-alcoholic fatty liver disease is present in up to 90% of these patients and can progress to hepatitis and hepatocarcinoma. The relationship of this liver disease and obesity is already well known; however, it is possible that some parameters of the comorbidities are more related than others in the pathophysiology of the disease. Aim: Was analyzed the relationship between non-alcoholic fatty liver disease (NAFLD) and the comorbidities of metabolic syndrome in morbidly obese patients...
November 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28076480/preliminary-analysis-of-interleukin-6-changes-in-pre-and-postoperative-in-diabetic-patients-with-bmi-35-submitted-to-partial-duodenal-switch
#14
Luciano Dias de Oliveira Reis, Paulo Afonso Nunes Nassif, Fernando Issamu Tabushi, Fábio Quirillo Milléo, Giovani Marino Favero, Bruno Luiz Ariede, Cassiana Franco Dias Dos Reis, Bruno Franco Dalabona
Background: Studies related to obesity have shown association with metabolic syndrome. Data showing that obesity is capable to cause low grade chronic inflammation, without its classic signs and symptoms, call attention to researches to study different cells types and the mechanism of the inflammatory process. Aim: To evaluate the variation of glycated hemoglobin (HbA1c) and the pro-inflammatory cytokine interleukin-6 (IL6) in diabetic patients with BMI <35 kg/m2 in the pre and postoperative of partial duodenal switch...
November 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28076319/impact-of-nutrition-on-pollutant-toxicity-an-update-with-new-insights-into-epigenetic-regulation
#15
Jessie B Hoffman, Michael C Petriello, Bernhard Hennig
Exposure to environmental pollutants is a global health problem and is associated with the development of many chronic diseases, including cardiovascular disease, diabetes and metabolic syndrome. There is a growing body of evidence that nutrition can both positively and negatively modulate the toxic effects of pollutant exposure. Diets high in proinflammatory fats, such as linoleic acid, can exacerbate pollutant toxicity, whereas diets rich in bioactive and anti-inflammatory food components, including omega-3 fatty acids and polyphenols, can attenuate toxicant-associated inflammation...
January 11, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28075222/expression-of-myd88-in-adipose-tissue-of-obese-people-is-there-some-role-in-the-development-of-metabolic-syndrome
#16
Ada M Cuevas, Mariana Lazo, Isabel Zuñiga, Fernando Carrasco, Jim J Potter, Veronica Alvarez, Marcos Berry, Fernando Maluenda, Mario Ferrario, Jeanne M Clark
BACKGROUND: The mechanism leading to the development of metabolic complications in obese individuals is not fully understood. Thus, the objective of this study was to examine differences in insulin resistance, inflammation, cytokine and adipokine levels, and expression of selected genes across obese individuals with different number of metabolic syndrome (MetS) components. METHODS: Forty obese individuals who underwent bariatric surgery, divided in three groups based on the number of components of MetS, in addition to abdominal obesity (0, 1, and 2-3 additional components), were studied...
January 11, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28074994/-normoglycemic-diabetic-ketoacidosis-in-pregnancy-report-of-one-case
#17
Margarita Rivas M, Pamela Belmar Z, Pilar Durruty A, Lilian Sanhueza M, Gloria López S
Normoglycemic diabetic ketoacidosis should be suspected in pregnant women presenting nausea, vomiting, abdominal pain and anorexia. We report a 39 years old woman with a 32 weeks pregnancy who sought emergency care due to hyperemesis. She was hospitalized with the following diagnoses: pregnancy hypertension syndrome, gestational diabetes, morbid obesity and poor prenatal control. The evaluation of the feto-placental unit showed perception of fetal movements, non-reactive non-stress baseline record and a biophysical profile of 6/8...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28074977/-association-of-c-reactive-protein-levels-with-metabolic-syndrome-in-adults-a-population-based-study
#18
Patricia Bustos, Bernardita Rosas, Pablo Román, Juan Villagrán, Hugo Amigo
BACKGROUND: Metabolic syndrome is highly prevalent among adults in Chile and represents a health risk. AIM: To determine the relationship between metabolic syndrome (MetS) and its components, with C reactive protein levels (CRP) as an inflammation marker. MATERIAL AND METHODS: The population studied consisted of 736 individuals born in a hospital from Valparaíso Region, aged between 32-38 years at the time of the study. MetS was identified according to the Adult Treatment Panel (ATP) III guidelines and inflammation was measured using ultra-sensitive CRP...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28074349/second-generation-antipsychotic-utilization-and-metabolic-parameter-monitoring-in-an-inpatient-pediatric-population-a-retrospective-analysis
#19
Valerie D Nolt, Alexandra Victoria Kibler, G Lucy Wilkening, Tanya J Fabian
BACKGROUND: Second-generation antipsychotics (SGAs) are prescribed for a variety of indications and are strongly associated with adverse metabolic effects. Studies of pediatric outpatients have revealed several deficiencies in monitoring practices for adverse effects associated with SGAs. OBJECTIVE: Our objective was to characterize SGA prescribing and metabolic parameter monitoring (MPM) in an inpatient pediatric population. METHODS: Patients aged <18 years and discharged on SGA treatment between 1 November 2013 and 30 April 2014 from an inpatient psychiatric institution in Pittsburgh, PA, USA were included...
January 10, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28072592/metabolic-syndrome-associated-osteoarthritis
#20
Alice Courties, Jérémie Sellam, Francis Berenbaum
PURPOSE OF REVIEW: Interest in the metabolic syndrome-associated osteoarthritis phenotype is increasing. Here, we summarize recently published significant findings. RECENT FINDINGS: Meta-analyses confirmed an association between type 2 diabetes and osteoarthritis and between cardiovascular diseases and osteoarthritis. Recent advances in the study of metabolic syndrome-associated osteoarthritis have focused on a better understanding of the role of metabolic diseases in inducing or aggravating joint damage...
January 7, 2017: Current Opinion in Rheumatology
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