Martin Marek, Elizabeth Ramos-Morales, Gisele F A Picchi-Constante, Theresa Bayer, Carina Norström, Daniel Herp, Policarpo A Sales-Junior, Eloise P Guerra-Slompo, Kristin Hausmann, Alokta Chakrabarti, Tajith B Shaik, Annika Merz, Edouard Troesch, Karin Schmidtkunz, Samuel Goldenberg, Raymond J Pierce, Marina M Mourão, Manfred Jung, Johan Schultz, Wolfgang Sippl, Nilson I T Zanchin, Christophe Romier
Writing and erasing of posttranslational modifications are crucial to phenotypic plasticity and antigenic variation of eukaryotic pathogens. Targeting pathogens' modification machineries, thus, represents a valid approach to fighting parasitic diseases. However, identification of parasitic targets and the development of selective anti-parasitic drugs still represent major bottlenecks. Here, we show that the zinc-dependent histone deacetylases (HDACs) of the protozoan parasite Trypanosoma cruzi are key regulators that have significantly diverged from their human counterparts...
December 21, 2021: Cell Reports