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https://www.readbyqxmd.com/read/29935410/clinical-outcome-of-recurrent-afebrile-seizures-in-children-with-benign-convulsions-associated-with-mild-gastroenteritis
#1
Boman Chen, Min Cheng, Siqi Hong, Shuang Liao, Jiannan Ma, Tingsong Li, Li Jiang
PURPOSE: To assess the clinical outcome and evolution of recurrent afebrile seizures in children initially diagnosed with benign convulsions associated with mild gastroenteritis (CwG). METHODS: We reviewed and analyzed the medical records of 37 patients who were diagnosed as CwG at onset, followed by recurrent afebrile seizures and followed up for at least 24 months. RESULTS: The follow-up period ranged from 2 to 7 years (median, 40.1 months)...
May 30, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29935375/caenorhabditis-elegans-in-high-throughput-screens-for-anti-infective-compounds
#2
REVIEW
Nicholas D Peterson, Read Pukkila-Worley
New classes of antimicrobials that are effective therapies for infections with multi-drug resistant pathogens are urgently needed. The nematode Caenorhabditis elegans has been incorporated into small molecule screening platforms to identify anti-infective compounds that provide protection of a host during infection. The use of a live animal in these screening systems offers several advantages, including the ability to identify molecules that boost innate immune responses in a manner advantageous to host survival and compounds that disrupt bacterial virulence mechanisms...
June 20, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29935266/first-detection-of-anti-besnoitia-spp-specific-antibodies-in-horses-and-donkeys-in-italy
#3
Luca Villa, Alessia Libera Gazzonis, Gema Álvarez-García, Carlos Diezma-Díaz, Sergio Aurelio Zanzani, Maria Teresa Manfredi
Among Apicomplexa protozoa infecting equids, Besnoitia spp., Toxoplasma gondii and Neospora spp. represent important issues from a sanitary and zootechnical viewpoint. However, only scarce epidemiological data are available on the spread of the infections in horses and donkeys in Europe. Therefore, a serosurvey was planned to estimate the prevalence of these Sarcocystidae species in Italian equids. Serum samples from 268 horses and 18 donkeys raised in Italy were collected and serologically analyzed to detect anti-Besnoitia spp...
June 20, 2018: Parasitology International
https://www.readbyqxmd.com/read/29935210/comparison-of-serological-assays-using-pneumococcal-proteins-or-polysaccharides-for-detection-of-streptococcus-pneumoniae-infection-in-children-with-community-acquired-pneumonia
#4
Igor C Borges, Dafne C Andrade, Nina Ekström, Camilla Virta, Merit Melin, Annika Saukkoriipi, Maija Leinonen, Olli Ruuskanen, Helena Käyhty, Cristiana M Nascimento-Carvalho
The aim of this study was to compare the results of serological assays using pneumococcal proteins or polysaccharides for the detection of pneumococcal infection in childhood pneumonia. Serological assays measured IgG against eight pneumococcal proteins (Ply,CbpA,PspA1,PspA2,PcpA,PhtD,StkP-C,PcsB-N), C-polysaccharide [in the whole study population, n = 183], or 19 pneumococcal capsular polysaccharides (1,2,4,5,6B,7F,8,9 V,10A,11A,12F,14,15B,17F,18C,19F,20,23F,33F) [only in a subgroup of patients, n = 53] in paired serum samples of children aged <5 years-old hospitalized with clinical and radiological diagnosis of community-acquired pneumonia...
June 20, 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29934964/drug-permeation-and-metabolism-in-mycobacterium-tuberculosis-prioritising-local-exposure-as-essential-criterion-in-new-tb-drug-development
#5
REVIEW
Lloyd Tanner, Paolo Denti, Lubbe Wiesner, Digby F Warner
Anti-tuberculosis (TB) drugs possess diverse abilities to penetrate the different host tissues and cell types in which infecting Mycobacterium tuberculosis bacilli are located during active disease. This is important since there is increasing evidence that the respective "lesion-penetrating" properties of the front-line TB drugs appear to correlate well with their specific activity in standard combination therapy. In turn, these observations suggest that rational efforts to discover novel treatment-shortening drugs and drug combinations should incorporate knowledge about the comparative abilities of both existing and experimental anti-TB agents to access bacilli in defined physiological states at different sites of infection, as well as avoid elimination by efflux or inactivation by host or bacterial metabolism...
June 22, 2018: IUBMB Life
https://www.readbyqxmd.com/read/29934751/evaluation-of-serum-markers-for-gastric-cancer-and-its-precursor-diseases-among-high-incidence-and-mortality-rate-of-gastric-cancer-area
#6
Boldbaatar Gantuya, Khasag Oyuntsetseg, Dashdorj Bolor, Yansan Erdene-Ochir, Ruvjir Sanduijav, Duger Davaadorj, Tegshee Tserentogtokh, Tomohisa Uchida, Yoshio Yamaoka
BACKGROUND: Mongolia has the highest mortality rate of gastric cancer. The early detection of cancer and down-staging screening for high risk patients are essential. Therefore, we aimed to validate serum markers for stratifying patients for further management. METHODS: Endoscopy and histological examination were performed to determine high risk and gastric cancer patients. Rapid urease test, culture and histological tests were performed to diagnose Helicobacter pylori infection...
June 22, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29934691/a-new-iron-iii-complex-containing-sulfadiazine-inhibits-the-proliferation-and-induces-cystogenesis-of-toxoplasma-gondii
#7
Juliana de A Portes, Nathália F B Azeredo, Pedro G T Siqueira, Tatiana Guinancio de Souza, Christiane Fernandes, Adolfo Horn, Dalber R S Candela, Wanderley de Souza, Renato A DaMatta, Sérgio H Seabra
We have previously shown that metallocomplexes can control the growth of Toxoplasma gondii, the agent that causes toxoplasmosis. In order to develop new metallodrugs to treat this disease, we investigated the influence of the coordination of sulfadiazine (SDZ), a drug used to treat toxoplasmosis, on the biological activity of the iron(III) complex [Fe(HBPClNOL)Cl2 ]·H2 O, 1, (H2 BPClNOL=N-(2-hydroxybenzyl)-N-(2-pyridylmethyl)(3-chloro)(2-hydroxy)-propylamine). The new complex [(Cl)(SDZ)Fe(III)(μ-BPClNOL)2 Fe(III)(SDZ)(Cl)]·2H2 O, 2, which was obtained by the reaction between complex 1 and SDZ, was characterized using a range of physico-chemical techniques...
June 22, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29934599/chalcomoracin-is-a-potent-anticancer-agent-acting-through-triggering-oxidative-stress-via-a-mitophagy-and-paraptosis-dependent-mechanism
#8
Haote Han, Chih-Chien Chou, Ruyi Li, Jiangyun Liu, Lin Zhang, Wei Zhu, Jin Hu, Bingxian Yang, Jingkui Tian
Chalocomoracin (CMR), one of the major secondary metabolites found in fungus-infected mulberry leaves, is a potent anticancer agent. However, its anticancer mechanism remains elusive. Here, we demonstrated the potent anti-tumor activity and molecular mechanism of CMR both in vitro and in vivo. We showed for the first time that CMR treatment markedly promoted paraptosis along with extensive cytoplasmic vacuolation derived from the endoplasmic reticulum, rather than apoptosis, in PC-3 and MDA-MB-231cell lines...
June 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29934302/the-role-of-heparan-sulfate-in-host-macrophage-infection-by-leishmania-species
#9
REVIEW
Marissa L Maciej-Hulme, Mark A Skidmore, Helen P Price
The leishmaniases are a group of neglected tropical diseases caused by parasites from the Leishmania genus. More than 20 Leishmania species are responsible for human disease, causing a broad spectrum of symptoms ranging from cutaneous lesions to a fatal visceral infection. There is no single safe and effective approach to treat these diseases and resistance to current anti-leishmanial drugs is emerging. New drug targets need to be identified and validated to generate novel treatments. Host heparan sulfates (HSs) are abundant, heterogeneous polysaccharides displayed on proteoglycans that bind various ligands, including cell surface proteins expressed on Leishmania promastigote and amastigote parasites...
June 22, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29933735/-seroprevalence-of-pertussis-toxin-antibody-in-manisa-province-of-turkey-after-six-years-implementation-of-acellular-pertussis-vaccine
#10
Özgen Alpay Özbek, İbrahim Mehmet Ali Öktem, Can Hüseyin Hekimoğlu, Özgür Sekreter, Mestan Emek, Gonca Atasoylu, Ayla Açıkgöz, Nur Demirpençe, Ali Ceylan, Elif Sanem Baykal, Belgin Ünal
Vaccination is the most effective way of preventing pertussis disease. Turkey commenced a routine infant immunization program using whole cell (wP) pertussis vaccine in 1968. Immunization accelerated in 1985 after participation of Turkey in the Expanded Programme on Immunization initiated by the World Health Organization. Acellular vaccine (aP) replaced wP in 2008 and a booster was added to age 6 in 2010. The immunization programme was successful in reducing the morbidity rate from 20.58 per 100.000 in 1970 to the lowest level of 0...
April 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29933411/time-trends-in-dyspepsia-and-association-with-h-pylori-and-work-related-stress-an-observational-study-in-white-collar-employees-in-1996-and-2015
#11
Stefanie Braig, Simon Berger, David Rothenbacher, Stefanie Schmid, Thomas Seufferlein, Hermann Brenner, Dietrich Rothenbacher, Harald Gündel
PURPOSE: We aimed to describe time trends in functional dyspepsia and the association of dyspepsia-related factors, Helicobacter pylori (H. pylori) and work-related stress with functional dyspepsia in white collar employees in 1996 and 2015. MATERIALS AND METHODS: Repeat cross-sectional study conducted in 1996 (n = 190, response rate = 76.1) and 2015 (n = 195, response rate = 40.2) within a health insurance company in South-West Germany. Dyspeptic symptoms measured according to the Rome III criteria, effort-reward imbalance and further work- or dyspepsia-related factors were assessed by self-administered questionnaire...
2018: PloS One
https://www.readbyqxmd.com/read/29933218/activity-of-mefloquine-and-mefloquine-derivatives-against-echinococcus-multilocularis
#12
Reto Rufener, Dominic Ritler, Jana Zielinski, Luca Dick, Emerson Teixeira da Silva, Adriele da Silva Araujo, Deborah Elisabeth Joekel, David Czock, Christine Goepfert, Adriana Marques Moraes, Marcus Vinicius Nora de Souza, Joachim Müller, Meike Mevissen, Andrew Hemphill, Britta Lundström-Stadelmann
The cestode E. multilocularis causes the disease alveolar echinococcosis (AE) in humans. The continuously proliferating metacestode (larval stage) of the parasite infects mostly the liver and exhibits tumor-like growth. Current chemotherapeutical treatment options rely on benzimidazoles, which are rarely curative and have to be applied daily and life-long. This can result in considerable hepatotoxicity and thus treatment discontinuation. Therefore, novel drugs against AE are urgently needed. The anti-malarial mefloquine was previously shown to be active against E...
June 15, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29933043/detection-of-immune-complexes-and-evaluation-of-alcoholic-individuals-serological-profile-in-the-diagnosis-of-strongyloidiasis
#13
Alana A S Gonçalves, Camila A de Lopes, Henrique T Gonzaga, Ana Lúcia R Gonçalves, Marcelo A Levenhagen, Luiz Carlos M de Oliveira, Julia M Costa-Cruz
Strongyloidiasis is a human parasitosis that is considered a public health problem. Early diagnosis of this infection is extremely important in immunocompromised patients (i.e. subjects with alcoholism). This study aimed to evaluate anti-Strongyloides immunoglobulin G (IgG) and immunoglobulin A (IgA), assess levels of circulating immune complexes (IC) and determine IgG avidity in serum samples from alcoholic and nonalcoholic individuals. A total of 140 blood samples were collected from male individuals (70 alcoholic and 70 nonalcoholic subjects)...
June 19, 2018: Parasitology International
https://www.readbyqxmd.com/read/29933042/antiprotozoal-activity-of-magnesium-oxide-mgo-nanoparticles-against-cyclospora-cayetanensis-oocysts
#14
Eman M Hussein, Shahira A Ahmed, Amira B Mokhtar, Sherine M Elzagawy, Samah H Yahi, Abdalla M Hussein, Farid Al-Tantawey
Outbreaks of Cyclospora cayetanensis infection have been linked to consumption of food and water contaminated by oocysts that can survive both physical and chemical disinfectants. Magnesium oxide (MgO) nanoparticles (NPs) can be potentially used in food as bactericides. In this study, C. cayetanensis pre- and post-sporulated oocysts were exposed to MgO NPs with different doses ranging from 1.25-25 mg/ml. With comparison to control, the antiprotozoal activity of MgO NPs was evaluated by identifying the median effective concentration dose (EC50 ), lethal concentration dose (LC90 ), microscopically changes on treated oocysts and rates of sporulation...
June 19, 2018: Parasitology International
https://www.readbyqxmd.com/read/29932395/molecular-characterization-of-hepatitis-b-virus-hbv-in-african-children-living-in-australia-identifies-genotypes-and-variants-associated-with-poor-clinical-outcome
#15
Elizabeth G Bannister, Lilly Yuen, Margaret Littlejohn, Rosalind Edwards, Vitina Sozzi, Danni Colledge, Xin Li, Stephen Locarnini, Winita Hardikar, Peter A Revill
Migration from sub-Saharan Africa is contributing to the rising incidence of chronic hepatitis B (CHB) infection and its complications in Australia. African CHB is associated with unique genotypes, such as E and A1, which are associated with reduced vaccine efficacy and early-onset hepatocellular carcinoma, respectively, although the prevalence of these genotypes outside Africa is poorly described. Treatment-naïve children of African origin with CHB were recruited at the Royal Children's Hospital Melbourne...
June 22, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29932291/in-vivo-evidence-that-the-cannabinoid-receptor-2-63-rr-variant-is-associated-with-the-acquisition-and-or-expansion-of-hiv-infection
#16
C Sagnelli, C Uberti-Foppa, H Hasson, G Bellini, C Minichini, S Salpietro, E Messina, D Barbanotti, M Merli, F Punzo, N Coppola, A Lazzarin, E Sagnelli, F Rossi
OBJECTIVES: The aim of the study was to investigate whether the rs35761398 variants of the cannabinoid receptor 2 (CB2) gene may influence the acquisition of HIV infection and the clinical presentation of HIV/hepatitis C virus (HCV) coinfection. METHODS: We compared 166 HIV/HCV-coinfected patients with 186 HCV-monoinfected patients, all with biopsy-proven chronic hepatitis (using the Ishak scoring system), naïve for anti-HCV treatment and tested for the CB2 rs35761398 polymorphism (using the TaqMan assay)...
June 22, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29932039/effect-of-prolonged-anti-hm1-imss-entamoeba-histolytica-antibody-activity-in-humoral-and-cellular-immunity-of-experimentally-induced-animal-model
#17
Swati Bagde, Vinod Singh
BACKGROUND: The Cellular immunity plays an important role in amoebic infections, whereas humoral immune responses have little influence on the outcome of the disease. Chronic infestation with E. histolytica, a common protozoan parasite, has been associated with autoimmune phenomena, including the appearance of antibodies to colonic epithelial cells. The mechanism whereby the protozoan parasite E. histolytica causes suppression of the immune response to allow it to survive in humans is unclear...
June 21, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29931992/endoscopic-closure-of-tracheoesophageal-fistula-for-tuberculosis-with-an-over-the-scope-clip
#18
Gabriel Mosquera Klinger, Andrea Holguín-Cardona
Surgical management has been the main approach for enteral fistulae. This approach is usually complex due to comorbidities, a wasted nutritional state and anatomical difficulties related to prior multiple interventions. Therefore, endoscopic methods such as clips, self-expanding metal stent (SEMS) and recently, the over scope clip (OTSC®) are increasing in popularity and use. Herein, we present the case of a patient with a HIV infection who was admitted due to respiratory symptoms. Radiological and microbiological studies documented a tracheoesophageal fistula due to tuberculosis (TB) and cytomegalovirus (CMV) infection...
June 22, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29931564/antibodies-to-influenza-virus-hemagglutinin-in-the-2016-2017-epidemic-season-in-poland
#19
E Hallmann-Szelińska, K Cieślak, D Kowalczyk, K Szymański, L B Brydak
The aim of the study was to determine the level of antibodies against hemagglutinin of influenza viruses in the sera of 1,050 patients stratified into 7 different age groups during the 2016/2017 epidemic season in Poland. The method consisted of using the hemagglutination inhibition test (HAI). The findings confirmed the presence of anti-hemagglutinin antibodies against the following influenza virus antigens: A/California/7/2009 (H1N1) pdm09, A/Hong Kong/4801/2014 (H3N2), and B/Brisbane/60/2008. The level of anti-hemagglutinin antibodies differed across the age groups investigated, with the highest values in patients aged 10-14 years...
June 22, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29930977/regulation-of-gastric-lgr5-ve-cell-homeostasis-by-bone-morphogenetic-protein-bmp-signaling-and-inflammatory-stimuli
#20
Wei Ye, Hidehiko Takabayashi, Yitian Yang, Maria Mao, Elise S Hibdon, Linda C Samuelson, Kathryn A Eaton, Andrea Todisco
Background & Aims: Gastric Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) cells exert important functions during injury and homeostasis. Bone morphogenetic protein (BMP) signaling regulates gastric inflammation and epithelial homeostasis. We investigated if BMP signaling controls the fate of Lgr5+ve cells during inflammation. Methods: The H + /K + -adenosine triphosphatase β-subunit promoter was used to express the BMP inhibitor noggin ( Nog ) in the stomach ( H + /K + -Nog mice)...
2018: Cellular and Molecular Gastroenterology and Hepatology
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