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https://www.readbyqxmd.com/read/29054523/glandular-hair-constituents-of-mallotus-philippinensis-muell-fruit-act-as-tyrosinase-inhibitors-insights-from-enzyme-kinetics-and-simulation-study
#1
Hridya Hemachandran, Fagun Jain, Sankari Mohan, Thirumal Kumar D, George Priya Doss C, Siva Ramamoorthy
The glandular hair extracts from the fruit rind of Mallotus philippinensis Muell. is employed to treat various skin infections, however the anti-tyrosinase activity remains unknown. Hence the present study inspected on the anti-melanogenic activity of M. philippinensis constituents. Lineweaver Burk plot revealed mixed inhibition for Rottlerin; non-competitive type of inhibition for mallotophilippen A and B respectively. Thermodynamic studies resulted in static quenching forming ground state complex with higher binding constant temperature dependently...
October 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29054033/hepatitis-c-antibody-prevalence-among-mexico-city-prisoners-injecting-legal-and-illegal-substances
#2
Omar Silverman-Retana, Edson Serván-Mori, Sandra I McCoy, Sarah Larney, Sergio Bautista-Arredondo
BACKGROUND: Hepatitis C virus (HCV) infection is highly prevalent among prisoners and this prevalence estimates reach 64% among prisoners who inject illicit drugs. Prisons are important sites for HCV transmission in the absence of access to sterile injecting equipment; hence, it can be transmitted between prisoners who share contaminated needles and syringes. We aimed to estimate the prevalence of risk factors for anti-HCV prevalence, with particular interest on injecting behavior, and to assess correlates of anti-HCV positivity among Mexico City prisoners...
October 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29053818/effect-of-dietary-supplementation-of-nitrocompounds-on-salmonella-colonization-and-ileal-immune-gene-expression-in-laying-hens-challenged-with-salmonella-enteritidis
#3
Pratima Adhikari, D E Cosby, N A Cox, W K Kim
Foodborne disease caused by Salmonella Enteritidis (SE) is one of the important public health and economic concerns. A study was conducted to determine the effect of supplementation with 2-nitroethanol (NE) and 2-nitropropanol (NP) on Salmonella recovery of internal organs as well as on the immune gene expression in the ileum of laying hens. Thirty-six White Leghorns were orally gavaged with nalidixic acid resistant Salmonella Enteritidis (SENR). Hens were housed individually in wire-laying cages and randomly assigned to six dietary treatments: T1 = SENR unchallenged (negative control), T2 = SENR challenged (positive control), T3 = SENR challenged + 100 ppm NE, T4 = SENR challenged + 200 ppm NE, T5 = SENR challenged + 100 ppm NP, and T6 = SENR challenged + 200 ppm NP...
October 5, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053700/come-to-the-light-side-in-vivo-monitoring-of-pseudomonas-aeruginosa-biofilm-infections-in-chronic-wounds-in-a-diabetic-hairless-murine-model
#4
Alessandra M Agostinho Hunt, Jacob A Gibson, Casandra L Larrivee, Sandra O'Reilly, Svetlana Navitskaya, Julia V Busik, Christopher M Waters
The presence of bacteria as structured biofilms in chronic wounds, especially in diabetic patients, is thought to prevent wound healing and resolution. Chronic mouse wounds models have been used to understand the underlying interactions between the microorganisms and the host. The models developed to date rely on the use of haired animals and terminal collection of wound tissue for determination of viable bacteria. While significant insight has been gained with these models, this experimental procedure requires a large number of animals and sampling is time consuming...
October 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29052521/high-seroprevalance-of-neospora-caninum-in-dogs-in-victoria-australia-compared-to-20%C3%A2-years-ago
#5
Sarah Sloan, Jan Šlapeta, Abdul Jabbar, Jaimie Hunnam, Bert De Groef, Grant Rawlin, Christina McCowan
BACKGROUND: Canids are definitive hosts of the apicomplexan parasite Neospora caninum, the leading cause of abortion in cattle worldwide. For horizontal transmission from canids to occur, oocysts of N. caninum must be shed by the definitive host into the environment of susceptible intermediate hosts such as cattle. The purpose of this study was to determine the prevalence of N. caninum in canids in Victoria, Australia's leading dairy producing state. RESULTS: Neospora-like oocysts were observed in 8% (18/234) of faecal samples from wild dogs, domestic dogs and red foxes from Victoria, Australia...
October 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29052304/immunotherapy-for-hepatitis-b-in-the-direct-acting-anti-viral-era-reevaluating-the-thymosin-%C3%AE-1-efficacy-trials-in-light-of-a-combination-therapy-approach
#6
Paul H Naylor, Milton G Mutchnick
Hepatitis B virus (HBV) causes both acute and chronic hepatitis and infects large numbers of individuals worldwide. Unfortunately, prediction of typical clinical outcome is problematic and there is considerable variability in the frequency, duration and severity of disease progression. The mainstay of HBV treatment is directed towards the suppression of HBV replication by nucleos(t)ide analogs (NUCs). The use of immunomodulators such as α-Interferon and thymosin α1 can, in select patients, result in elimination of both HBsAg and HBeAg...
October 20, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29052135/hepatitis-c-virus-associated-cancers
#7
Zhigang Yi, Zhenghong Yuan
Most hepatitis C virus (HCV) infection results in persistent infection. Significant portion of chronic HCV-infected patients develop hepatocellular carcinoma (HCC). Chronic hepatitis C is also associated with extrahepatic manifestations, including cryoglobulinemia, lymphoma, insulin resistance, type 2 diabetes, and neurological disorders. The molecular mechanisms of how HCV infection causes liver cancer are largely unknown. HCV replication or viral proteins may perturb cellular hemostasis and induce the generation of reactive oxygen species (ROS); viral components or viral replication products act as agonist to trigger innate immune response and cause chronic inflammation...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29052056/development-of-an-antigen-capture-elisa-for-beak-and-feather-disease-virus
#8
Chia-Fang Ho, Shr-Wei Huang, Kun-Wei Chan, Jian-Shin Wu, Shu-Ping Chang, Chi-Young Wang
Psittacine beak and feather disease (PBFD) is characterised by degenerative feather, feather dystrophy, and beak deformity. Sometimes acute forms can lead to fatal cases in nestlings. The worldwide distribution of this disease affects numerous species of parrots with an average prevalence of 40%, including in Taiwan. The pathogen of PBFD is beak and feather disease virus (BFDV), which is a single-stranded circular DNA virus, circovirus. To date, hemagglutination and PCR assays have been routinely used to detect this virus...
October 19, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29051993/treatment-related-sinusoidal-obstruction-syndrome-in-children-with-de-novo-acute-lymphoblastic-leukemia-during-intensification
#9
Casey L McAtee, Netta Schneller, Julienne Brackett, M Brooke Bernhardt, Eric S Schafer
PURPOSE: Sinusoidal obstruction syndrome (SOS), also known as veno-occlusive disease, has been described following treatment of acute lymphoblastic leukemia (ALL) with the anti-metabolite 6-thioguanine (6-TG). Previous studies incorporating daily 6-TG into maintenance chemotherapy demonstrated a high incidence of SOS, typically presenting after prolonged exposures to 6-TG. 6-TG continues to be used as a single, 14-day burst during intensification; however, SOS associated with brief courses of 6-TG is poorly described...
October 19, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29051818/successful-discontinuation-of-immunoglobulin-g-replacement-at-age-10-in-a-patient-with-immunoglobulin-g2-deficiency
#10
Masayoshi Shinjoh, Yukio Sakiyama, Shinichiro Sekiguchi, Takao Takahashi
CONTEXT: Immunoglobulin G2 deficiency that persists beyond the age of 6 years is likely to be permanent. CASE REPORT: We report on a young Japanese female, diagnosed as having immunoglobulin G2 deficiency and low anti-pneumococcal immunoglobulin G2 antibody levels when 3 years old, with a subsequent medical history of frequent respiratory infections and asthma. Monthly intravenous immunoglobulin replacement therapy was started at 4 years of age. After 8 years of age, an anti-pneumococcal immunoglobulin G2 trough level could be maintained with administration intervals longer than 6 weeks, and after 9 years and 10 months of age, therapy was discontinued...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/29050950/modeling-and-comparative-study-of-the-spread-of-zoonotic-visceral-leishmaniasis-from-northern-to-central-tunisia
#11
Belhassen Kaab, Elyes Zhioua
During the last twenty years, zoonotic visceral leishmaniasis (ZVL) spread from the north characterized by humid, sub-humid, and semi-arid bio-climates to the arid areas located in Central Tunisia. In order to understand the eco-epidemiological factors involved in the distribution of ZVL, both a sero-epidemiological and an entomological investigation were performed in two governorates situated in two different bio-geographical areas: Bizerte in the north and Kairouan in the center. A mathematical model for transmission of ZVL was built, describing the disease dynamic in these areas...
October 16, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29050898/sushi-cervice-and-gnathostomiasis-a-case-report-and-review-of-imported-infections
#12
REVIEW
Jordan Leroy, Marjorie Cornu, Anne Sophie Deleplancque, Séverine Loridant, Emmanuel Dutoit, Boualem Sendid
We describe a case of imported cutaneous gnathostomiasis in a Thai patient living in France. Gnathostomiasis is a zoonosis of food origin. The disease is endemic in Southeast Asia and Latin America. However, over the past 30 years, an increasing number of imported cases has been described in Europe and America. The disease is rare in Western Europe and the majority of cases described had a cutaneous clinical presentation. The disease may sometimes be confused with allergy, leading to a delay in diagnosis. Visceral symptoms are rare but may follow severe attacks...
October 16, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29050778/the-expressions-and-roles-of-different-forms-of-il-22-in-mycobacterium-tuberculosis-infection
#13
Yuanyuan Liu, Qinfang Ou, Qianqian Liu, Yan Gao, Jing Wu, Bingyan Zhang, Xinhua Weng, Lingyun Shao, Wenhong Zhang
Despite evidence suggesting an anti-Mycobacterium tuberculosis effector function of CD4+ T cells that produce and retain IL-22 in macaques, the general role of IL-22 in tuberculosis infection is still poorly characterized. To explore the immune mechanism in the pathogenesis of tuberculosis in humans, here we evaluated different forms of IL-22 in populations with different tuberculosis infection statuses. We enrolled 156 subjects including 49 patients with pulmonary tuberculosis, 27 patients with tuberculous pleurisy (TPE), 38 individuals with latent tuberculous infection (LTBI) and 42 healthy controls (HC)...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29050765/alveolar-macrophages-from-tuberculosis-patients-display-an-altered-inflammatory-gene-expression-profile
#14
Lelia Lavalett, Hector Rodriguez, Hector Ortega, Wolfgang Sadee, Larry S Schlesinger, Luis F Barrera
Alveolar macrophages (AMs) are major targets of Mycobacterium tuberculosis (Mtb) infection, critical during the progression of active tuberculosis (TB). The complex immunopathology of TB generates diverse microenvironments in the lung, which shape immune responses by AMs. In the current study, we perform whole genome microarray transcriptional profiling on RNA isolated from AMs from TB patients (AMsTB) compared to AMs from control subjects (AMsCT) using bronchoalveolar lavage (BAL). Our hypothesis was that systemic effects on the local lung microenvironment during TB affect the transcriptional response of AMsTB...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29050757/ionophore-a23187-shows-anti-tuberculosis-activity-and-synergy-with-tebipenem
#15
Wei Huang, Julien Briffotaux, Xinwei Wang, Lili Liu, Pei Hao, Mena Cimino, Maria Virginia Buchieri, Amine Namouchi, Jose-Antonio Ainsa, Brigitte Gicquel
The objective of this study was to find molecules with anti-mycobacterial activity from a natural compounds library, investigate their mechanisms of resistance, and assess their synergy with antibiotics. We screened a library of 2582 natural compounds with Mycobacterium aurum with the aim of identifying molecules with anti-mycobacterial activity. The hits with the lowest MICs in M. aurum were also tested for their antimicrobial activity in other mycobacterial species including M. tuberculosis complex strains...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29050127/-immune-related-pneumonitis-caused-by-programmed-death-1-inhibitor-pembrolizumab-a-case-report-and-literature-review
#16
Y L Chen, J Zhao, R Jia, H Y Wang, J Zheng, C Q Bai, M Z Wang, J M Xu
Objective: To investigate the risk factors, clinical manifestations, radiological features, diagnosis, treatment and prognosis of immune-related pneumonitis caused by programmed death-1(PD-1)/PD-L1 inhibitors. Methods: The clinical data of immune-related pneumonitis caused by PD-1 inhibitor Pembrolizumab in a patient with advanced esophageal carcinoma admitted to the 307(th) Hospital of Chinese People's Liberation Army was retrospectively analyzed and the related literatures were reviewed. We searched Medline database using the keywords"PD-1 inhibitor","PD-L1 inhibitor","Pembrolizumab","Nivolumab","Atezolizumab"combined with"Pneumonitis"by Mar 31, 2017...
October 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29050003/cantharidin-inhibits-the-growth-of-triple-negative-breast-cancer-cells-by-suppressing-autophagy-and-inducing-apoptosis-in-vitro-and-in-vivo
#17
Hong-Chang Li, Zhi-Hua Xia, Ya-Feng Chen, Fan Yang, Wen Feng, Han Cai, Yi Mei, Yi-Ming Jiang, Ke Xu, Dian-Xu Feng
BACKGROUND/AIMS: Cantharidin, a type of terpenoid secreted by the blister beetle Mylabris phalerata (Pallas), has attracted great attention in cancer therapy because of its potential anti-cancer activities. Here, we report the effects on apoptosis and autophagy in human triple-negative breast cancer (TNBC) cell lines after treatment with cantharidin and attempt to elucidate the underlying mechanisms. METHODS: MDA-MB-231 and MDA-MB-468 cells were treated with cantharidin and cell proliferation was examined using CCK-8 and clone formation assays...
October 19, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29049752/cytomegalovirus-infection-in-living-donor-and-cadaveric-lung-transplantations
#18
Keiji Ohata, Toyofumi F Chen-Yoshikawa, Koji Takahashi, Akihiro Aoyama, Hideki Motoyama, Kyoko Hijiya, Masatsugu Hamaji, Toshi Menju, Toshihiko Sato, Makoto Sonobe, Shunji Takakura, Hiroshi Date
Objectives: Cytomegalovirus (CMV) infection remains a major cause of morbidity after lung transplantation. Some studies have reported prognostic factors for the postoperative development of CMV infection in cadaveric lung transplantation (CLT), but no research has been performed in living-donor lobar lung transplantation (LDLLT). Therefore, we analysed the possible risk factors of post-transplant CMV infection and the differences between LDLLT and CLT. Methods: The development of CMV disease and viraemia in 110 patients undergoing lung transplantation at Kyoto University Hospital in 2008-2015 were retrospectively assessed...
August 7, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049207/cutaneous-mucormycosis-in-a-patient-with-lupus-nephritis-a-case-report-and-review-of-literature
#19
Wenrong Cheng, Guoqin Wang, Min Yang, Lijun Sun, Hongrui Dong, Yipu Chen, Hong Cheng
RATIONALE: Mucormycosis is a rare fungal infection but life-threatening, especially in lupus nephritis (LN). Mucormycosis may manifest as rhino-orbital-cerebral, pulmonary, cutaneous, gastrointestinal, renal, or disseminated forms. PATIENT CONCERNS: We report a case of a 52-year-old woman with cutaneous mucormycosis infection who was admitted because of LN. DIAGNOSES: Histopathological analysis of the lesion confirmed the Rhizopus microspores from the family Mucoraceae...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048633/in%C3%A2-vitro-and-in%C3%A2-vivo-anti-primary-effusion-lymphoma-activities-of-fucoidan-extracted-from-cladosiphon-okamuranus-tokida
#20
Chie Ishikawa, Naoki Mori
Primary effusion lymphoma (PEL) caused by Kaposi's sarcoma-associated herpesvirus (KSHV) is characterized by lymphomatous effusion in body cavities and poor prognosis. There is still no effective treatment for PEL. Fucoidan, a major sulfated polysaccharide isolated from brown seaweeds, has an attractive array of bioactivities such as cancer inhibition. However, the effects of fucoidan on PEL cells remain unclear. We investigated the anti-PEL effects of fucoidan obtained from Cladosiphon okamuranus Tokida cultivated in Okinawa...
September 20, 2017: Oncology Reports
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