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https://www.readbyqxmd.com/read/28075321/effects-of-exercise-and-lifestyle-intervention-on-oxidative-stress-in-chronic-kidney-disease
#1
David M Small, Kassia S Beetham, Erin J Howden, David R Briskey, David W Johnson, Nicole M Isbel, Glenda C Gobe, Jeff S Coombes
OBJECTIVES: Determine the effects of a 12-month exercise and lifestyle intervention program on changes in plasma biomarkers of oxidative stress in pre-dialysis chronic kidney disease (CKD) patients. METHODS: A total of 136 stage 3-4 CKD patients were randomized to receive standard nephrological care with (N = 72) or without (N = 64) a lifestyle and exercise intervention for 12 months. Plasma total F2-isoprostanes (IsoP), glutathione peroxidase (GPX) activity, total antioxidant capacity (TAC), anthropometric and biochemical data were collected at baseline and at 12 months...
January 11, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28028051/predicting-5-year-risk-of-rrt-in-stage-3-or-4-ckd-development-and-external-validation
#2
Emily B Schroeder, Xiuhai Yang, Micah L Thorp, Brent M Arnold, David C Tabano, Amanda F Petrik, David H Smith, Robert W Platt, Eric S Johnson
BACKGROUND AND OBJECTIVES: Only a minority of patients with CKD progress to renal failure. Despite the potential benefits of risk stratification in the CKD population, risk prediction models are not routinely used. Our objective was to develop and externally validate a clinically useful and pragmatic prediction model for the 5-year risk of progression to RRT in stage 3 or 4 CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We used a retrospective cohort design...
January 6, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27941734/health-related-quality-of-life-in-children-with-nephrotic-syndrome-in-bangladesh
#3
M Rahman, S Afroz, R Ali, M Hanif
Outcome of children with nephrotic syndrome has continued to improve over time. However minimal data exist to describe health-related quality of life in children with nephrotic syndrome. This cross sectional study was conducted over a period of six months to assess the health related quality of life in children with nephrotic syndrome in the Department of Pediatric Nephrology, Dhaka Medical College Hospital, Bangladesh. Fifty children (age ranged 2-12 years) with nephrotic syndrome who had three or more relapses diagnosed at least one year back receiving treatment and on follow up were included in this study...
October 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27924467/indian-pediatric-postgraduate-s-perspective-on-future-career-intentions
#4
Latha M Sneha, Manipriya Ravindran, Rekha Kumar, Padmasani Venkatraman, Julius Scott, LakshmiNarayan Kannan
OBJECTIVE: To determine the factors that influence Pediatric residents to pursue a subspecialty career and establish their choice of future workplace. METHODS: The present questionnaire based study was conducted during a National level pediatric post graduate exam refresher course in Chennai, India and involved Pediatric residents from all parts of India. Datas was analysed with the statistical package for social sciences (SPSS, version 18.0). RESULTS: Seventy five respondents participated in the study...
December 7, 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27900959/effect-of-vitamin-c-supplementation-on-lipid-profile-serum-uric-acid-and-ascorbic-acid-in-children-on-hemodialysis
#5
Ghada Mohamed El Mashad, Hanan M ElSayed, Nahla A Nosair
Children with end-stage renal disease (ESRD) suffer from dyslipidemia and hyperuricemia that might play a causal role in the progression of cardiovascular disease (CVD). The aim of the study is to assess the effects of Vitamin C supplementation on uric acid, ascorbic acid, and serum lipid levels among children on hemodialysis (HD). This prospective study was conducted in the pediatric nephrology unit at Menoufia University Hospital. The study included a total of 60 children with ESRD on maintenance HD therapy...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27900718/survival-and-time-to-transplantation-of-peritoneal-dialysis-versus-hemodialysis-for-end-stage-renal-disease-patients-competing-risks-regression-model-in-a-single-italian-center-experience
#6
Marta Rigoni, Emanuele Torri, Giandomenico Nollo, Diana Zarantonello, Alessandro Laudon, Laura Sottini, Giovanni Maria Guarrera, Giuliano Brunori
AIMS: Despite several studies reporting similar outcomes for peritoneal dialysis (PD) and hemodialysis (HD), the former is underused worldwide, with a PD prevalence of 15% in Italy. In 2008, the Unit of Nephrology and Dialysis of the Healthcare Trust of the Autonomous Province of Trento implemented a successful PD program which has increased the proportion of PD incident patients from 7 to 47%. We aimed to assess the effect of this extensive use of PD by comparing HD and PD in terms of survival and time-to-transplantation...
November 29, 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/27872833/impact-of-renal-transplantation-on-cardiac-morphological-and-functional-characteristics-in-children-and-adults
#7
Sahier Omar El-Khashab, Eman El-Sayed Mohamed, Mahmoud A Soliman, Hussein Heshmat Kassem, Amin Roshdy Soliman
AIM: To compare the effects of renal transplantation on cardiac functions in children and adults. METHODS: One hundred and ten patients attending the nephrology outpatient clinic were enrolled in this study and were divided into six groups. The first two groups consisted each of 30 renal transplant patients who had a successful renal transplantation more than six months, but less than one year. Group I were less than 18 years and group II were more than 18 years...
November 6, 2016: World Journal of Nephrology
https://www.readbyqxmd.com/read/27795790/-profile-of-diabetic-nephropathy-at-the-national-reference-general-hospital-of-n-djamena-chad
#8
Ibrahim Hamat, Guillaume Mahamat Abderraman, Mouhamadou Moustapha Cisse, Mahamat Youssouf, Matar Saboune Djafar, Dionadji Mbainguinam, Tara Fotclossou
INTRODUCTION: Diabetes mellitus is a real health problem and its complications affect many organs including the kidneys. Early diagnosis of diabetic nephropathy allows to treat patients more effectively and with a multidisciplinary approach, to slow its progression in chronic renal failure. Few studies have been conducted in Africa in this field of study. In Chad, we have no statistics on renal disease related to diabetes. That is why we propose to study diabetic nephropathy with the aim of analyzing the profile of diabetic nephropathy in patients at the National Reference General Hospital of N'Djamena (CHAD)...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27790455/efficacy-and-safety-of-complete-raas-blockade-with-aliskiren-in-patients-with-refractory-proteinuria-who-were-already-on-combined-ace-inhibitor-arb-and-aldosterone-antagonist
#9
Prabitha Panattil, M Sreelatha
INTRODUCTION: Proteinuria is always associated with intrinsic kidney disese and is a strong predictor of later development of End Stage Renal Disease (ESRD). As Renin Angiotensin Aldosterone System (RAAS) has a role in mediating proteinuria, inhibitors of this system are renoprotective and patients with refractory proteinuria are put on a combination of these agents. The routinely employed triple blockade of RAAS with Angiotensin Converting Enzyme (ACE) inhibitor, ARB and Aldosterone antagonist has many limitations...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27767356/etiology-clinical-profile-and-short-term-outcome-of-acute-kidney-injury-in-children-at-a-tertiary-care-pediatric-nephrology-center-in-pakistan
#10
Vina Tresa, Afshan Yaseen, Ali Asghar Lanewala, Seema Hashmi, Sabeeta Khatri, Irshad Ali, Muhammed Mubarak
BACKGROUND: The reported prevalence rates and etiologies of acute kidney injury (AKI) are quite variable in different regions of the world. The current study was planned to determine the etiology, clinical profile, and short-term outcome of pediatric AKI at our hospital. METHODS: A prospective, observational study was carried out from April 2014 to March 2015. All pediatric patients (1 month to ≤15 years) diagnosed as AKI using modified pRIFLE criteria were studied and followed for 3 months to document short-term outcome...
October 21, 2016: Renal Failure
https://www.readbyqxmd.com/read/27749383/improving-treatment-for-patients-with-chronic-kidney-disease
#11
Kendra Thomsen, Kim Zuber, Jane Davis, Greg Thomas
OBJECTIVE: Kidneys in a Box (KIB) was developed to identify the effect of a performance improvement CME (PI-CME) project on the management of patients with diabetes who are at risk for chronic kidney disease (CKD). The program provided nonnephrology practitioners with research-based interventions known to slow CKD progression. METHODS: PAs were given the KIB tool kit, which described the scope of CKD identified high-risk diagnoses such as diabetes, and listed six modifiable risk factors that have been shown to slow progression of diabetic kidney disease when implemented...
November 2016: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/27676711/neurogenic-detrusor-overactivity-in-patients-with-hereditary-spastic-paraplegias
#12
Charles Joussain, Jonathan Levy, Audrey Charlanes, Alexia Even, Laetitia Falcou, Emmanuel Chartier-Kastler, Pierre Denys
OBJECTIVE: Hereditary spastic paraplegia (HSP) represents a clinically and genetically heterogeneous group of neurodegenerative diseases, with a worldwide estimated prevalence of 1.3/100,000 [1]. The "pure" form of HSP is a characterized by a progressive spastic paraplegia, often associated with lower urinary tract symptoms (LUTS) (72.4% to 77.6%) [2,3]. However, urologic complications are rarely reported. The aim of this study was to characterize clinical and urodynamic aspects of LUTS following HSP, and to describe treatment and urological complications of LUTS in a large series of HSP patients...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27640125/intestinal-microbiota-in-pediatric-patients-with-end-stage-renal-disease-a-midwest-pediatric-nephrology-consortium-study
#13
Janice Crespo-Salgado, V Matti Vehaskari, Tyrus Stewart, Michael Ferris, Qiang Zhang, Guangdi Wang, Eugene E Blanchard, Christopher M Taylor, Mahmoud Kallash, Larry A Greenbaum, Diego H Aviles
BACKGROUND: End-stage renal disease (ESRD) is associated with uremia and increased systemic inflammation. Alteration of the intestinal microbiota may facilitate translocation of endotoxins into the systemic circulation leading to inflammation. We hypothesized that children with ESRD have an altered intestinal microbiota and increased serum levels of bacterially derived uremic toxins. METHODS: Four groups of subjects were recruited: peritoneal dialysis (PD), hemodialysis (HD), post-kidney transplant and healthy controls...
September 17, 2016: Microbiome
https://www.readbyqxmd.com/read/27633863/diving-into-the-abyss-of-undiscovered-kidney-function-related-factors
#14
Sophie Limou, Afshin Parsa
Meta-analyses and reintroduction of biological knowledge are 2 classic strategies to increase genomewide association study statistical power and overcome the burden of multiple testing. These strategies have empowered the nephrology community to discover new signals associated with kidney function and nephropathies. Here we discuss the current genomewide association study limitations and strategies to dive further into the abyss of yet-to-be discovered kidney function-related factors.
October 2016: Kidney International
https://www.readbyqxmd.com/read/27596082/-a-retrospective-study-on-nutritional-status-and-growth-and-development-of-37-children-with-chronic-kidney-disease-stage-3-to-5
#15
R Bao, C Y Chen
OBJECTIVE: To retrospectively analyze the nutritional status and growth and development situation of the children with chronic kidney disease stage 3 to 5 when they were diagnosed at the first visit. METHOD: After searching for the data of all the hospitalized cases during January 2007 to September 2015 in the Department of Nephrology of Children's Hospital Affiliated to the Capital Institute of Pediatrics from the medical record system, data of 37 cases with complete clinical data were collected; all these cases were diagnosed as chronic kidney disease stage 3 to 5 according to the diagnostic criteria...
September 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27557856/exploration-of-pathological-prediction-of-chronic-kidney-diseases-by-a-novel-theory-of-bi-directional-probability
#16
Yuan Yang, Min Luo, Li Xiao, Xue-Jing Zhu, Chang Wang, Xiao Fu, Shu-Guang Yuan, Fang Xiao, Hong Liu, Zheng Dong, Fu-You Liu, Lin Sun
In the clinic, the pathological types of chronic kidney diseases (CKD) are considered references for choosing treatment protocols. From a statistical viewpoint, a non-invasive method to predict pathological types of CKD is a focus of our work. In the current study, following a frequency analysis of the clinical indices of 588 CKD patients in the department of nephrology, a third-grade class-A hospital, a novel theory is proposed: "bi-directional cumulative probability dichotomy". Further, two models for the prediction and differential diagnosis of CKD pathological type are established...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27555076/vitamin-d-treatment-effect-on-serum-endocan-and-high-sensitivity-c-reactive-protein-levels-in-renal-transplant-patients
#17
Omer Atis, Mustafa Keles, Erdem Cankaya, Hasan Dogan, Hulya Aksoy, Fatih Akcay
CONTEXT: Endocan is a marker showing endothelial dysfunction and inflammation. Significantly increased endocan levels have been observed in serum of patients with sepsis and cancer. OBJECTIVE: Our aim was to investigate the relationship between vitamin D treatment and serum endocan and high-sensitivity C-reactive protein (hs-CRP) levels as inflammatory markers in transplant patients. DESIGN: Prospective. SETTING: Nephrology clinic...
August 23, 2016: Progress in Transplantation
https://www.readbyqxmd.com/read/27531272/-clinical-features-of-multiple-myeloma-patients-with-renal-insufficiency-as-the-initial-clinical-manifestation
#18
R X Ma, Z L Li, T Wang, G H Wu, Y L Wu
OBJECTIVE: To analyze the clinical features of multiple myeloma (MM) with renal insufficiency as the initial manifestation, and to improve the level of clinical diagnosis of MM, and reducing misdiagnosis of this disease. METHODS: To retrospectively analyze the clinical data of 140 patients with MM, who were admitted in our Department of Nephrology and Hematology. They were diagnosed as MM by bone marrow aspiration biopsy. The patients were divided into renal insufficiency group and normal renal function group, based on the criterion of serum creatinine >177 μmol/L...
July 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/27501629/improving-the-care-of-patients-with-chronic-kidney-disease-using-group-visits-a-pilot-study-to-reflect-an-emphasis-on-the-patients-rather-than-the-disease
#19
Vicki Montoya, Mary Lou Sole, Anne E Norris
This two-group, repeated-measures experimental study assessed the efficacy of a nurse practitioner-facilitated chronic kidney disease (CKD) group visit (GV) model versus usual nephrology care for patients with Stage 4 CKD. The study enrolled patients from two sites of an outpatient nephrology practice (n = 30) and randomized subjects to usual care (n = 14) or to the GV model (n = 16). Data regarding CKD knowledge, self-efficacy/disease self-management, and physiologic measures were collected at baseline, 6 months, and 9 months...
May 2016: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/27496451/urinary-tract-infections-in-kidney-transplant-recipients-hospitalized-at-a-transplantation-and-nephrology-ward-1-year-follow-up
#20
J Gozdowska, M Czerwińska, Ł Chabros, G Młynarczyk, A Kwiatkowski, A Chmura, M Durlik
INTRODUCTION: The aim of this study was to investigate risk factors for urinary tract infections (UTI), the causative organisms of UTI and also their management and treatment. In addition, we evaluated the effects of UTI on renal graft function. METHODS: This analysis included 107 kidney transplant recipients (64% women) with a diagnosis of UTIs confirmed by positive results on urine culture. Type of pathogens, sensitivity to drugs, risk factors for infection, incidence of urosepsis, hospitalization period, treatment methods, and recurrence rates were analyzed...
June 2016: Transplantation Proceedings
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