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Qiaoli Chen, Chao Quan, Bingxian Xie, Liang Chen, Shuilian Zhou, Rachel Toth, David G Campbell, Shuangshuang Lu, Ryutaro Shirakawa, Hisanori Horiuchi, Chaojun Li, Zhongzhou Yang, Carol MacKintosh, Hong Yu Wang, Shuai Chen
Insulin and muscle contraction each stimulate translocation of the glucose transporter GLUT4 to the plasma membrane in skeletal muscle, an important process regulating whole-body glucose homeostasis. RalA mediates insulin-stimulated GLUT4 translocation; however, it is unclear how this small GTPase is regulated in skeletal muscle in response to insulin. Here, we identified GARNL1/RalGAPα1, a major α subunit of the Ral-GTPase activating protein in skeletal muscle, as a protein whose phosphorylation and binding to the regulatory 14-3-3 proteins is stimulated by insulin and also by muscle contraction...
August 2014: Cellular Signalling
Christianne M A Reijnders, Huib W van Essen, Birgitte T T M van Rens, Johannes H G M van Beek, Bauke Ylstra, Marinus A Blankenstein, Paul Lips, Nathalie Bravenboer
Skeletal integrity in humans and animals is maintained by daily mechanical loading. It has been widely accepted that osteocytes function as mechanosensors. Many biochemical signaling molecules are involved in the response of osteocytes to mechanical stimulation. The aim of this study was to identify genes involved in the translation of mechanical stimuli into bone formation. The four-point bending model was used to induce a single period of mechanical loading on the right tibia, while the contra lateral left tibia served as control...
2013: PloS One
Xu Shen, Hua Zeng, Liang Xie, Jun He, Jian Li, Xiujuan Xie, Chenglong Luo, Haiping Xu, Min Zhou, Qinghua Nie, Xiquan Zhang
BACKGROUND: Abundant evidence indicates that chicken reproduction is strictly regulated by the hypothalamic-pituitary-gonad (HPG) axis, and the genes included in the HPG axis have been studied extensively. However, the question remains as to whether any other genes outside of the HPG system are involved in regulating chicken reproduction. The present study was aimed to identify, on a genome-wide level, novel genes associated with chicken reproductive traits. METHODOLOGY/PRINCIPAL FINDING: Suppressive subtractive hybridization (SSH), genome-wide association study (GWAS), and gene-centric GWAS were used to identify novel genes underlying chicken reproduction...
2012: PloS One
Daoliang Lan, Cheng Tang, Mingyi Li, Hua Yue
Newcastle disease is an important viral infectious disease caused by Newcastle disease virus (NDV), which leads to severe economic losses in the poultry industry worldwide. The molecular mechanisms involved in the pathogenesis of NDV and the host-directed antiviral responses remain poorly understood. In this study, we screened and identified the differentially expressed transcripts from chicken spleen 36 h post NDV infection using suppression subtractive hybridization (SSH). From the SSH library, we obtained 140 significant differentially expressed sequence tags (ESTs), which could be divided into three categories: high homology genes (58), high homology ESTs (62) and novel ESTs (20)...
June 2010: Avian Pathology: Journal of the W.V.P.A
Chih-Feng Chen, Yow-Ling Shiue, Cheng-Ju Yen, Pin-Chi Tang, Hui-Chiu Chang, Yen-Pai Lee
The objective was to characterize the potential laying traits and underlying transcripts expressed in the hypothalamus and pituitary gland that were associated with egg production variability in five genetic stocks of chickens: two commercial lines, Red- (n=12) and Black-feather (n=14) Taiwan country chickens (TCCs); two selected lines of TCCs, B (high body weight/comb size; n=17) and L2 (high-egg production; n=14); and a commercial single comb White Leghorn (WL; n=17). Six laying traits, age at first egg, clutch length, pause length, oviposition lag within clutch, follicle rapid growth period, and rate of yolk accumulation were measured...
December 2007: Theriogenology
Lih-Ren Chen, Ching-Hsien Chao, Chih-Feng Chen, Yen-Pai Lee, Yi-Ling Chen, Yow-Ling Shiue
Expression levels of 33 high egg production candidate transcripts in Red-feather Taiwan country chickens (TCCs) were examined by quantitative reverse-transcription (RT) polymerase chain reactions (PCR) in this study. Candidate transcripts were previously identified from a L2-B (L2-subtract-B) hypothalamus/pituitary gland subtractive cDNA library. In this subtractive cDNA library, two divergently selected strains of TCCs, B and L2 were used. These two strains were originated from one single population and were further subjected (since 1982) to the selections of body weight/comb size (B) and eggs to 40wk of age (L2), respectively...
July 2007: Animal Reproduction Science
Thomas Schwarzbraun, John B Vincent, Axel Schumacher, Daniel H Geschwind, Joao Oliveira, Christian Windpassinger, Lisa Ofner, Michael K Ledinegg, Peter M Kroisel, Klaus Wagner, Erwin Petek
Previously, we have described the clinical and molecular characterization of a de novo 14q13.1-q21.1 microdeletion, less than 3.5 Mb in size, in a patient with severe microcephaly, psychomotor retardation, and other clinical anomalies. Here we report the characterization of the genomic structure of the human tuberin-like protein gene 1 (TULIP1; approved gene symbol GARNL1), a CpGisland-associated, brain-expressed candidate gene for the neurological findings in our patient, and its murine homologue. The human TULIP1 gene was mapped to chromosome band 14q13...
September 2004: Genomics
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