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https://www.readbyqxmd.com/read/29765966/further-clinical-evidence-for-the-effect-of-igf-1-on-hair-growth-and-alopecia
#1
Ralph M Trüeb
Observations on the Laron syndrome originally offered the opportunity to explore the effect of insulin-like growth factor 1 (IGF-1) deficiency on human hair growth and differentiation. According to its expression in the dermal hair papilla, IGF-1 is likely involved in reciprocal signaling. It has been shown to affect follicular proliferation, tissue remodeling, and the hair growth cycle, as well as follicular differentiation, identifying IGF-1 signaling as an important mitogenic and morphogenetic regulator in hair follicle biology...
April 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29763915/serum-from-chronic-hepatitis-b-patients-promotes-growth-and-proliferation-via-the-igf-ii-igf-ir-mek-erk-signaling-pathway-in-hepatocellular-carcinoma-cells
#2
Yuanyuan Ji, Zhidong Wang, Haiyan Chen, Lei Zhang, Fei Zhuo, Qingqing Yang
BACKGROUND/AIMS: Chronic hepatitis B virus (HBV) infection (CHB) plays a central role in the etiology of hepatocellular carcinoma (HCC). Emerging evidence implicates insulin-like growth factor (IGF)-II as a major risk factor for the growth and development of HCC. However, the relationship between HBV infection and IGF-II functions remains to be elucidated. METHODS: Levels of circulating IGF-II and IGF-I receptor (IGF-IR) in healthy donors (HDs) and CHB patients were tested by ELISA...
May 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29757421/stereotactic-radiosurgery-for-acromegaly-an-international-multicenter-retrospective-cohort-study
#3
Dale Ding, Gautam U Mehta, Mohana Rao Patibandla, Cheng-Chia Lee, Roman Liscak, Hideyuki Kano, Fu-Yuan Pai, Mikulas Kosak, Nathaniel D Sisterson, Roberto Martinez-Alvarez, Nuria Martinez-Moreno, David Mathieu, Inga S Grills, Kevin Blas, Kuei Lee, Christopher P Cifarelli, Gennadiy A Katsevman, John Y K Lee, Brendan McShane, Douglas Kondziolka, L Dade Lunsford, Mary Lee Vance, Jason P Sheehan
BACKGROUND: Stereotactic radiosurgery (SRS) is a treatment option for persistent or recurrent acromegaly secondary to a growth hormone secreting pituitary adenoma, but its efficacy is inadequately defined. OBJECTIVE: To assess, in a multicenter, retrospective cohort study, the outcomes of SRS for acromegaly and determine predictors. METHODS: We pooled and analyzed data from 10 participating institutions of the International Gamma Knife Research Foundation for patients with acromegaly who underwent SRS with endocrine follow-up of ≥6 mo...
May 10, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29744370/insulin-like-growth-factor-1-at-diagnosis-and-during-subsequent-years-in-adolescents-with-type-1-diabetes
#4
Simona I Chisalita, J Ludvigsson
Background: Type 1 diabetes (T1D) in adolescents is associated with alterations in the insulin-like factor system probably caused both by a deranged metabolism and insulinopenia in the portal vein. Objective: To study how the circulating IGF-1 is affected at diagnosis and during subsequent years in adolescents with T1D. Methods: Ten girls and ten boys with type 1 diabetes (T1D), aged 13.0 ± 1.4 (mean ± SD) years at diagnosis, took part in the study...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29743865/somatopause-weaknesses-of-the-therapeutic-approaches-and-the-cautious-optimism-based-on-experimental-ageing-studies-with-soy-isoflavones
#5
REVIEW
Vladimir Z Ajdžanovic, Svetlana Trifunovic, Dragana Miljic, Branka Šošic-Jurjevic, Branko Filipovic, Marko Miler, Nataša Ristic, Milica Manojlovic-Stojanoski, Verica Miloševic
The pathological phenomenon of somatopause, noticeable in hypogonadal ageing subjects, is based on the growth hormone (GH) production and secretion decrease along with the fall in GH binding protein and insulin-like growth factor 1 (IGF-1) levels, causing different musculoskeletal, metabolic and mental issues. From the perspective of safety and efficacy, GH treatment is considered to be highly controversial, while some other therapeutic approaches (application of IGF-1, GH secretagogues, gonadal steroids, cholinesterase-inhibitors or various combinations) exhibit more or less pronounced weaknesses in this respect...
2018: EXCLI journal
https://www.readbyqxmd.com/read/29739044/diagnostic-usefulness-of-insulin-like-growth-factor-1-and-insulin-like-growth-factor-binding-protein-3-in-children-with-suspected-pituitary-dwarfism
#6
Beata Zelazowska-Rutkowska, Marta Trusiak, Artur Bossowski, Bogdan Cylwik
BACKGROUND: Pituitary dwarfism (also known as short stature) is a medical condition in which the pituitary gland does not produce enough growth hormone (GH). To confirm the diagnosis of growth hormone deficiency the overnight profile of GH secretion and GH provocative tests are usually performed; however, due to wide GH fluctuations throughout the day and night and the invasiveness of stimulation tests, their clinical utility is limited. Therefore, screening for IGF-1 (insulin-like growth factor 1) and IGFBP-3 (insulin-like growth factor binding protein type 3) is proposed, suggesting that these tests provide a more accurate reflection of the mean plasma GH level, although the results of these tests are still problematic...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29713178/safety-study-is-there-a-pathologic-igf-1-pdgf-and-tgf-%C3%AE-cytokine-expression-caused-by-adjunct-bmp-7-in-tibial-and-femoral-non-union-therapy
#7
Christian Fischer, Christian Reiner, Gerhard Schmidmaier, Julian Doll, Christopher Child, Paul Alfred Grützner, Bahram Biglari, Sonja Boxriker, Arash Moghaddam
Background: In this prospective safety study, we investigated if the characteristic cytokine expression during bone regeneration is manipulated by the local application of bone morphogenetic protein-7 (BMP-7) in non-union surgery. Therefore, the levels of insulin like growth factor 1 (IGF-1), platelet-derived growth factor AB (PDGF-AB) and transforming growth factor beta (TGF-β) were compared between patients with the gold standard use of autologous bone graft (ABG) and those with additional application of BMP-7 as part of the diamond concept...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29695980/cardiac-remodeling-endothelial-cells-have-more-to-say-than-just-no
#8
REVIEW
Vincent F M Segers, Dirk L Brutsaert, Gilles W De Keulenaer
The heart is a highly structured organ consisting of different cell types, including myocytes, endothelial cells, fibroblasts, stem cells, and inflammatory cells. This pluricellularity provides the opportunity of intercellular communication within the organ, with subsequent optimization of its function. Intercellular cross-talk is indispensable during cardiac development, but also plays a substantial modulatory role in the normal and failing heart of adults. More specifically, factors secreted by cardiac microvascular endothelial cells modulate cardiac performance and either positively or negatively affect cardiac remodeling...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29679919/the-effect-of-growth-hormone-on-bioactive-igf-in-overweight-obese-women
#9
Laura E Dichtel, Mette Bjerre, Melanie Schorr, Miriam A Bredella, Anu V Gerweck, Brian M Russell, Jan Frystyk, Karen K Miller
OBJECTIVE: Overweight/obesity is characterized by decreased growth hormone (GH) secretion whereas circulating IGF-I levels are less severely reduced. Yet, the activity of the circulating IGF-system appears to be normal in overweight/obese subjects, as estimated by the ability of serum to activate the IGF-I receptor in vitro (bioactive IGF). We hypothesized that preservation of bioactive IGF in overweight/obese women is regulated by an insulin-mediated suppression of IGF-binding protein-1 (IGFBP-1) and IGFBP-2, and by suppression of IGFBP-3, mediated by low GH...
March 10, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29672904/growth-hormone-gh-insulin-like-growth-factor-1-igf-1-axis-hyperactivity-on-bone-fibrous-dysplasia-in-mccune-albright-syndrome
#10
Daniele Tessaris, Alison M Boyce, Margaret Zacharin, Patrizia Matarazzo, Roberto Lala, Luisa de Sanctis, Michael T Collins
CONTEXT: In fibrous dysplasia (BFD) normal bone and bone marrow are replaced by fibro-osseous tissue, leading to fracture, deformity and pain. BFD may be isolated, or in association with cutaneous hyperpigmentation and/or hyperfunctioning endocrinopathies, termed McCune-Albright syndrome (MAS). GH hypersecretion has been described in 10-20% of MAS-BFD patients. Aim of the study is to determine the impact of GH-insulin like growth factor 1 (IGF1) axis hyperactivity on MAS-BFD morbidities and the efficacy of GH excess therapy...
April 19, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29668981/wnts-role-in-bovine-folliculogenesis-and-estrogen-production
#11
B I Gomez, B H Aloqaily, C A Gifford, D M Hallford, J A Hernandez Gifford
Appreciation of mechanisms that affect steroidogenesis is critical to identifying compromising signals that may decrease reproductive efficiency. Follicle maturation and steroidogenesis requires coordinated actions from the pituitary gonadotropins, and local ovarian signaling molecules. Beta-catenin (CTNNB1), the lynchpin molecule of canonical wingless-type mouse mammary tumor virus integration site (WNT) signaling is required for maximal gonadotropin stimulation of steroid production from granulosa (GC) and luteal cells...
April 13, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29658436/thrombin-alters-human-endometrial-stromal-cell-differentiation-during-decidualization
#12
Samir N Babayev, Mohammed Kanchwala, Chao Xing, Yucel Akgul, Bruce R Carr, Ruth Ann Word
Vaginal bleeding and subchorionic hematomas are associated with increased risk of both early and late pregnancy loss. Thrombin generation may play a pivotal role in the development of these complications. To determine the effects of thrombin on human endometrial stromal cells (hESCs), cells were treated with thrombin at baseline or during decidualization with cyclic adenosine monophosphate (cAMP)+medroxyprogesterone acetate (MPA). Next-generation RNA sequencing revealed that markers of decidualization (IGF-1, IGFBP-1, and prolactin [PRL]) were induced after the initiation of decidualization, whereas thrombin suppressed insulin-like growth factor ( IGF)-1, Insulin-like growth factor binding protein ( IGFBP)-1, and PRL gene expression at baseline and during decidualization...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29603682/adipose-derived-stem-cells-improve-erectile-function-partially-through-the-secretion-of-igf-1-bfgf-and-vegf-in-aged-rats
#13
J Yang, Y Zhang, G Zang, T Wang, Z Yu, S Wang, Z Tang, J Liu
Adipose-derived stem cells (ADSCs) have recently been considered as a promising therapy for erectile dysfunction (ED). However, the mechanism of ADSC-based therapy is unclear. Insulin-like growth factor-1 (IGF-1), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) secreted by ADSCs were assessed in vitro. Sixteen 24-month-old male Sprague-Dawley rats were used for comparative analysis of 2-week treatment with labeled ADSCs or PBS. Eight additional 5-month-old rats were used as a young rat group...
March 30, 2018: Andrology
https://www.readbyqxmd.com/read/29593201/adipose-tissue-critical-contributor-to-the-development-of-prostate-cancer
#14
Uehara Hisanori, Tomoko Kobayashi, Minoru Matsumoto, Shunsuke Watanabe, Akiko Yoneda, Bando Yoshimi
The prostate is surrounded by periprostatic adipose tissue. Although adipose tissue was thought to play limited physiological roles, it has recently been recognized as an active endocrine organ, secreting growth factors and adipokines. Epidemiologically, obesity is associated with prostate cancer progression. A major mechanism to explain the link between obesity and cancer includes the insulin and insulin-like growth factor (IGF)-1 axis, sex steroids, and adipokines. When prostate cancer cells invade periprostatic adipose tissue, adipose tissue contributes to create the tumor microenvironment, mainly via adipokine secretion...
2018: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/29569265/three-dimensional-speckle-tracking-echocardiography-derived-left-atrial-deformation-analysis-in-acromegaly-results-from-the-magyar-path-study
#15
Árpád Kormányos, Péter Domsik, Anita Kalapos, Zsuzsanna Valkusz, Csaba Lengyel, Tamás Forster, Attila Nemes
INTRODUCTION: Acromegaly is a chronic and disfiguring hormonal disease caused by a benign growth hormone-secreting pituitary adenoma in most of the cases. The objective of this study was to investigate three-dimensional (3D) speckle tracking echocardiography (3DSTE)-derived left atrial (LA) volumetric and functional properties in patients with acromegaly. It was also examined whether the activity of acromegaly is associated with further alterations in these LA parameters. METHODS: A total of 23 patients with acromegaly were involved in this study...
March 22, 2018: Echocardiography
https://www.readbyqxmd.com/read/29567388/inducing-hair-follicle-neogenesis-with-secreted-proteins-enriched-in-embryonic-skin
#16
Sabrina Mai-Yi Fan, Chia-Feng Tsai, Chien-Mei Yen, Miao-Hsia Lin, Wei-Hung Wang, Chih-Chieh Chan, Chih-Lung Chen, Kyle K L Phua, Szu-Hua Pan, Maksim V Plikus, Sung-Liang Yu, Yu-Ju Chen, Sung-Jan Lin
Organ development is a sophisticated process of self-organization. However, despite growing understanding of the developmental mechanisms, little is known about how to reactivate them postnatally for regeneration. We found that treatment of adult non-hair fibroblasts with cell-free extract from embryonic skin conferred upon them the competency to regenerate hair follicles. Proteomics analysis identified three secreted proteins enriched in the embryonic skin, apolipoprotein-A1, galectin-1 and lumican that together were essential and sufficient to induce new hair follicles...
March 13, 2018: Biomaterials
https://www.readbyqxmd.com/read/29555080/non-islet-cell-tumour-hypoglycaemia-nicth-about-a-series-of-6-cases
#17
Arnaud Jannin, Stéphanie Espiard, Kanza Benomar, Christine Do Cao, Bénédicte Mycinski, Henri Porte, Michèle D'Herbomez, Nicolas Penel, Marie-Christine Vantyghem
The purpose of this study was to analyse the characteristics of 6 patients managed in a university hospital between 1996 and 2016 for non-islet cell tumor hypoglycemia (NICTH), a form of hypoglycaemia due to the paraneoplastic secretion of IGF-2 or its related substances. RESULTS: Three of these 6 patients (50%), aged over 69 years, including 2 with acromegaloid phenotype, presented with a pleural solitary fibrous tumor (SFT), with median diameter 20 cm (interquartile range, 12.5-20.5) with a low median SUV (3...
March 16, 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29535813/the-crosstalk-between-breast-carcinoma-associated-fibroblasts-and-cancer-cells-promotes-rhoa-dependent-invasion-via-igf-1-and-pai-1
#18
Julien Daubriac, Shiwei Han, Jelena Grahovac, Eve Smith, Abdel Hosein, Marguerite Buchanan, Mark Basik, Yves Boucher
Carcinoma-associated fibroblasts (CAFs) can remodel the extracellular matrix to promote cancer cell invasion, but the paracrine signaling between CAFs and cancer cells that regulates tumor cell migration remains to be identified. To determine how the interaction between CAFs and cancer cells modulates the invasiveness of cancer cells, we developed a 3-dimensional co-culture model composed of breast cancer (BC) MDA-MB-231 cell spheroids embedded in a collagen gel with and without CAFs. We found that the crosstalk between CAFs and cancer cells promotes invasion by stimulating the scattering of MDA-MB-231 cells, which was dependent on RhoA/ROCK/phospho MLC signaling in cancer cells but independent of RhoA in CAFs...
February 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29521487/growth-hormone-deficiency-and-pregnancy-any-role-for-substitution
#19
Greisa Vila, Anton Luger
Growth hormone (GH) is not approved for use during conception and pregnancy. Nevertheless, data from the clinical care practice reveal that most women concieve on GH replacement therapy (GHRT), and more than half continue on GHRT also during pregnancy. GH stimulates the hypothalamic-pituitary-gonadal axis at all levels, and there is evidence that GH deficiency impacts the morphology of reproductive organs, onset of puberty, ovarian function and fertility. Patients with hypopituitarism often conceive using assisted reproductive techniques and several studies support the benefit of GH supplementation for achieving fertility in women with growth hormone deficiency...
March 8, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29518183/cardioprotection-by-cardiac-progenitor-cell-secreted-exosomes-role-of-pregnancy-associated-plasma-protein-a
#20
Lucio Barile, Elisabetta Cervio, Vincenzo Lionetti, Giuseppina Milano, Alessandra Ciullo, Vanessa Biemmi, Sara Bolis, Claudia Altomare, Marco Matteucci, Dario Disilvestre, Tudor Emanuel Fertig, Tiziano Torre, Stefanos Demertzis, Pierluigi Mauri, Tiziano Moccetti, Giuseppe Vassalli
Aims: Cell therapy trials using cardiac-resident progenitor cells (CPCs) and bone marrow-derived mesenchymal stem/progenitor cells (BMCs) in patients after myocardial infarction have provided encouraging results. Exosomes, nanosized extracellular vesicles of endosomal origin, figure prominently in the bioactivities of these cells. However, a head-to-head comparison of exosomes from the two cell types has not been performed yet. Methods and Results: CPCs and BMCs were derived from cardiac atrial appendage specimens and sternal bone marrow, respectively, from patients (n=20; age, 69...
March 5, 2018: Cardiovascular Research
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