keyword
MENU ▼
Read by QxMD icon Read
search

igf-1 secretion

keyword
https://www.readbyqxmd.com/read/28508612/the-longevity-hormone-klotho-is-a-new-player-in-the-interacion-of-the-growth-hormone-insulin-like-growth-factor-1-axis
#1
Tami Rubinek, Ido Wolf, Dalit Modan-Moses
Klotho was first discovered as an aging-suppressor gene. Mice that do not express klotho die prematurely with multiple symptoms of aging, several of which are also characteristic of decreased GH/IGF-1 axis activity. Klotho is highly expressed in the brain, the kidney, and parathyroid and pituitary glands, but can also serve as a circulating hormone by its shedding, forming soluble klotho (sKlotho) that can be detected in blood, cerebrospinal fluid and urine. Several lines of evidence suggest an association between klotho levels and activity of the GH/IHG-1 axis: The GH-secreting cells in the anterior pituitary of klotho-deficient mice are hypotrophic; klotho levels are altered in subjects with pathologies of the GH/IGF-1 axis; and accumulating data indicate that klotho is a direct regulator of GH secretion...
September 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28500244/tamoxifen-reduces-hepatic-vldl-production-and-gh-secretion-in-women-a-possible-mechanism-for-steatosis-development
#2
Vita Birzniece, P Hugh R Barrett, Ken K Y Ho
CONTEXT: Growth hormone (GH) stimulates hepatic synthesis of very-low-density lipoproteins (VLDL), whereas hepatic steatosis develops as a result of GH deficiency. Steatosis is also a complication of tamoxifen treatment, the cause of which is not known. As tamoxifen inhibits the secretion and action of GH, we hypothesize that it induces steatosis by inhibiting hepatic VLDL export. AIM: To investigate whether tamoxifen reduces hepatic VLDL secretion. DESIGN: Eight healthy, normolipidemic women (age 64...
May 12, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28469926/primary-hypertrophic-osteoarthropathy-due-to-a-novel-slco2a1-mutation-masquerading-as-acromegaly
#3
Ruth Mangupli, Adrian F Daly, Elvia Cuauro, Paul Camperos, Jaime Krivoy, Albert Beckers
SUMMARY: A 20-year-old man with an 8-year history of progressive enlargement of his hands and feet, coarsening facial features, painful joints and thickened, oily skin was referred for investigation of acromegaly. On examination, the subject was of normal height and weight. He had markedly increased skin thickness around the forehead, eyelids and scalp with redundant skin folds. Bilateral painful knee swelling was accompanied by enlargement of the extremities, and his fingers were markedly clubbed...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28468523/non-essential-and-branched-chain-amino-acids-differentially-regulate-insulin-like-growth-factor-binding-protein-1-production-and-phosphorylation-in-hepg2-cells
#4
Kei Tanaka, Keiji Sakai, Miho Matsushima, Yukiko Matsuzawa, Tomoko Izawa, Yoichi Kobayashi, Mitsutoshi Iwashita
Deprivation of branched-chain amino acids (BCAAs) induces insulin-like growth factor binding protein-1 (IGFBP-1) production in HepG2 cells, while the role of non-essential amino acids (NEAAs) remains unknown. We investigated changes in IGFBP-1 production and phosphorylation induced by NEAAs and also examined its significance on IGF-I activity in HepG2 cells. We demonstrated that decreased BCAAs and increased NEAAs stimulated phosphorylated IGFBP-1 secretion. We also revealed that decreased BCAA-to-NEAA ratios enhanced phosphorylated IGFBP-1 secretion, while changes in the total amount of amino acids (AAs) had no effect...
May 4, 2017: Growth Factors
https://www.readbyqxmd.com/read/28462439/ameliorative-effect-of-ve-igf-i-and-hcg-on-the-fluoride-induced-testosterone-release-suppression-in-mice-leydig-cells
#5
Yuxiang Yu, Yongli Han, Ruiyan Niu, Jundong Wang, Ram Kumar Manthari, Mohammad Mehdi Ommati, Zilong Sun
Excessive consumption of fluoride (F) through drinking, eating, and/or environmental contaminants induces chronic toxicity known as fluorosis. Our previous research has shown that fluorosis was associated with male reproductive disorders. The current study is designed to explain the protective effect of vitamin E (VE), insulin-like growth factor-I (IGF-I), and human chorionic gonadotropin (hCG) against natrium fluoride (NaF)-induced alterations in isolated Leydig cells (LCs). These NaF-induced alterations include decreased cell proliferation, steroidogenesis, and relative gene expression...
May 1, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28454879/expansion-of-cd26-positive-fibroblast-population-promotes-keloid-progression
#6
Yu Xin, Xiangsheng Wang, Ming Zhu, Miao Qu, Melia Bogari, Li Lin, Zin Mar Aung, Wei Chen, Xiaojun Chen, Gang Chai, Yan Zhang
BACKGROUND: Keloid is a skin fibrosis disease that characterised by invasive growth of fibroblasts and aberrant deposition of extracellular matrix. Studies indicated that keloid fibroblasts (KFs) is a class of 'activated' fibroblasts, which show accelerated proliferation and excessive extracellular matrix formation as compared with normal fibroblasts (NFs). However, the mechanism underlying keloid fibroblasts dysfunction is still unknown. OBJECTIVE: To verify CD26 expression difference between KFs and NFs, and investigate the function of CD26 positive fibroblasts in keloid progression...
April 25, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28453740/enhanced-coupling-within-gonadotropic-and-adrenocorticotropic-axes-by-moderate-exercise-in-healthy-men
#7
Ferdinand Roelfsema, Rebecca J Yang, Thomas P Olson, Michael J Joyner, Paul Y Takahashi, Johannes D Veldhuis
Context: Exercise elicits incompletely defined adaptations of metabolic and endocrine milieu, including the gonadotropic and the corticotropic axes. Objective: To quantify the impact of acute exercise on coordinate LH and testosterone and ACTH and cortisol secretion in healthy men in relation to age. Participantsand design: Prospectively randomized, within-subject cross-over, study in 23 men, aged 19-77 yr. Subjects underwent rest and 30 min of mixed exercise at 65% of maximal aerobic capacity with 10-min blood sampling between 0700 and 1300 h 2 wks apart...
April 27, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28449948/sunitinib-specifically-augments-glucose-induced-insulin-secretion
#8
Stefan Z Lutz, Axel Ullrich, Hans-Ulrich Häring, Susanne Ullrich, Felicia Gerst
The tyrosine kinase inhibitor sunitinib is used for the treatment of numerous cancers in humans. In diabetic patients, sunitinib lowers blood glucose levels and improves glycaemic control. This study aims to analyse whether sunitinib has specific and direct effects on insulin secreting β-cells. Regulation of insulin secretion, of cellular cAMP levels and activation of signalling pathways were examined upon exposure of rat insulinoma INS-1E cells to sunitinib under specific stimulatory and inhibitory conditions...
April 24, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28439054/-calcium-and-bone-metabolism-across-women-s-life-stages-the-effects-of-oral-contraceptives-low-dose-estrogen-progestin-on-bone-metabolism-bone-mass-and-geometry-in-adolescent-and-young-adult-women
#9
Hiroya Okano
Estrogens have a biphasic action on pubertal and/or adolescent skeletal growth. Low levels of estrogen may increase the periosteal expansion through the increase in the sensitivity of bone for mechanical stimuli and the secretion of IGF-1. On the other hand, high estrogen concentrations may inhibit periosteal bone formation. To use OC/LEP(oral contraceptive/low dose estrogen-progestin) during adolescence, meaning exposure to high levels of estrogen, may prevent the acquisition of physiologic peak of bone mass...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28425576/bone-marrow-adipose-and-lung-tissue-derived-murine-mesenchymal-stromal-cells-release-different-mediators-and-differentially-affect-airway-and-lung-parenchyma-in-experimental-asthma
#10
Soraia C Abreu, Mariana A Antunes, Debora G Xisto, Fernanda F Cruz, Vivian C Branco, Elga Bandeira, Jamil Zola Kitoko, Almair F de Araújo, Ludmilla Dellatorre-Texeira, Priscilla C Olsen, Daniel J Weiss, Bruno L Diaz, Marcelo M Morales, Patricia R M Rocco
Mesenchymal stromal cells (MSCs) from different sources have differential effects on lung injury. To compare the effects of murine MSCs from bone marrow (BM), adipose tissue (AD), and lung tissue (LUNG) on inflammatory and remodeling processes in experimental allergic asthma, female C57BL/6 mice were sensitized and challenged with ovalbumin (OVA) or saline (C). Twenty-four hours after the last challenge, mice received either saline (50 µl, SAL), BM-MSCs, AD-MSCs, or LUNG-MSCs (10(5) cells per mouse in 50 µl total volume) intratracheally...
June 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28424159/prolonged-elimination-of-negative-feedback-control-mechanisms-along-the-insulin-signalling-pathway-impairs-%C3%AE-cell-function-in-vivo
#11
Roi Isaac, Yaron Vinik, Sigalit Boura-Halfon, Lydia Farack, Sarina Streim, Eytan Elhanany, Zvi Kam, Yehiel Zick
Cellular stress and pro-inflammatory cytokines induce phosphorylation of insulin receptor substrate (IRS) proteins at Ser sites that inhibit insulin and IGF-1 signalling. We therefore examined the effects of mutation of five 'inhibitory' Ser phosphorylation sites on IRS2 function in transgenic mice that overexpress, selectively in pancreatic β cells, either wild-type (WT) or a mutated IRS2 protein (IRS2(5A)). Islets size, number, and mRNA levels of catalase and superoxide dismutase, were increased, while those of nitric oxide synthase were decreased in 7-10 weeks old IRS2(5A)-β mice compared to IRS2(WT)-β mice...
April 19, 2017: Diabetes
https://www.readbyqxmd.com/read/28419894/muscle-cell-communication-in-development-and-repair
#12
REVIEW
Alexis R Demonbreun, Elizabeth M McNally
Under basal conditions, postnatal skeletal muscle displays little cell turnover. With injury, muscle initiates a rapid repair response to reseal damaged membrane, reactivating many developmental pathways to facilitate muscle regeneration and prevent tissue loss. Muscle precursor cells become activated accompanied by differentiation and fusion during both muscle growth and regeneration; inter-cellular communication is required for successful completion of these processes. Cellular communication is mediated by lipids, fusogenic membrane proteins, and exosomes...
April 15, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28396686/expression-of-somatostatin-receptor-2-in-somatotropinoma-correlated-with-the-short-term-efficacy-of-somatostatin-analogues
#13
Wenjuan Liu, Lina Xie, Min He, Ming Shen, Jingjing Zhu, Yeping Yang, Meng Wang, Ji Hu, Hongying Ye, Yiming Li, Yao Zhao, Zhaoyun Zhang
The expression of somatostatin receptor subtypes (SSTRs) in pituitary growth hormone- (GH-) secreting adenomas may predict the response to somatostatin analogues (SSA). Our aim was to evaluate the value of the immunohistochemical (IHC) scores of 2 subtypes, SSTR2 and SSTR5, in predicting the short-term efficacy of SSA therapy in patients with active acromegaly. Ninety-three newly diagnosed acromegalic patients were included in our study. These patients were categorized into either a SSA-pretreated group (SA, n = 63) or a direct-surgery group (DS, n = 30), depending on whether or not presurgical SSA treatment was received...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28390436/n-myc-downstream-regulated-gene-2-ndrg2-promoter-methylation-and-expression-in-pituitary-adenoma
#14
Paulina Vaitkiene, Indre Valiulyte, Brigita Glebauskiene, Rasa Liutkeviciene
BACKGROUND: Pituitary adenoma (PA) is a benign primary tumor that arises from the pituitary gland and is associated with ophthalmological, neurological and endocrinological abnormalities. However, causes that increase tumor progressing recurrence and invasiveness are still undetermined. Several studies have shown N-myc downstream regulated gene 2 (NDRG2) as a tumor suppressor gene, but the role of NDRG2 gene in pituitary adenoma pathogenesis has not been elucidated. The aim of our research has been to examine NDRG2 mRNA expression in PA and to determine the associations between the NDRG2 gene epigenetic changes and the development of recurrence or invasiveness of PA and patient clinical data...
April 8, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28389653/identification-of-igf-1-enhanced-cytokine-expressions-targeted-by-mir-181d-in-glioblastomas-via-an-integrative-mirna-mrna-regulatory-network-analysis
#15
Kuo-Hao Ho, Peng-Hsu Chen, Edward Hsi, Chwen-Ming Shih, Wei-Chiao Chang, Chia-Hsiung Cheng, Cheng-Wei Lin, Ku-Chung Chen
The insulin-like growth factor (IGF)-1 signaling is relevant in regulating cell growth and cytokine secretions by glioblastomas. MicroRNAs determine the cell fate in glioblastomas. However, relationships between IGF-1 signaling and miRNAs in glioblastoma pathogenesis are still unclear. Our aim was to validate the IGF-1-mediated mRNA/miRNA regulatory network in glioblastomas. Using in silico analyses of mRNA array and RNA sequencing data from The Cancer Genome Atlas (TCGA), we identified 32 core enrichment genes that were highly associated with IGF-1-promoted cytokine-cytokine receptor interactions...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28372721/vitamin-d-across-growth-hormone-gh-disorders-from-gh-deficiency-to-gh-excess
#16
REVIEW
A Ciresi, C Giordano
The interplay between vitamin D and the growth hormone (GH)/insulin-like growth factor (IGF)-I system is very complex and to date it is not fully understood. GH directly regulates renal 1 alpha-hydroxylase activity, although the action of GH in modulating vitamin D metabolism may also be IGF-I mediated. On the other hand, vitamin D increases circulating IGF-I and the vitamin D deficiency should be normalized before measurement of IGF-I concentrations to obtain reliable and unbiased IGF-I values. Indeed, linear growth after treatment of nutritional vitamin D deficiency seems to be mediated through activation of the GH/IGF-I axis and it suggests an important role of vitamin D as a link between the proliferating cartilage cells of the growth plate and GH/IGF-I secretion...
April 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28366834/the-wilms-tumor-protein-wt1-stimulates-transcription-of-the-gene-encoding-insulin-like-growth-factor-binding-protein-5-igfbp5
#17
Miriam Müller, Anja Bondke Persson, Katharina Krueger, Karin M Kirschner, Holger Scholz
Insulin-like growth factor (IGF) binding proteins (IGFBPs) constitute a family of six secreted proteins that regulate the signaling of insulin-like growth factors (IGFs). IGFBP5 is the most conserved family member in vertebrates and the major IGF binding protein in bone. IGFBP5 is required for normal development of the musculoskeletal system, and various types of cancer frequently express high levels of IGFP5. Here we identify the gene encoding IGFBP5 as a novel downstream target of the Wilms tumor protein WT1...
July 1, 2017: Gene
https://www.readbyqxmd.com/read/28349931/adipokines-leptin-adiponectin-resistin-differentially-regulate-all-hormonal-cell-types-in-primary-anterior-pituitary-cell-cultures-from-two-primate-species
#18
André Sarmento-Cabral, Juan R Peinado, Lisa C Halliday, María M Malagon, Justo P Castaño, Rhonda D Kineman, Raúl M Luque
Adipose-tissue (AT) is an endocrine organ that dynamically secretes multiple hormones, the adipokines, which regulate key physiological processes. However, adipokines and their receptors are also expressed and regulated in other tissues, including the pituitary, suggesting that locally- and AT-produced adipokines might comprise a regulatory circuit that relevantly modulate pituitary cell-function. Here, we used primary pituitary cell-cultures from two normal nonhuman-primate species [Papio-anubis/Macaca-fascicularis] to determine the impact of different adipokines on the functioning of all anterior-pituitary cell-types...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28341329/body-mass-index-and-insulin-like-growth-factor-1-as-risk-factors-for-discordant-growth-hormone-and-insulin-like-growth-factor-1%C3%A2-levels-following-pituitary-surgery-in-acromegaly
#19
Shuo Zhang, Yilin Li, Xiaopeng Guo, Lu Gao, Wei Lian, Yong Yao, Ming Feng, Xinjie Bao, Renzhi Wang, Bing Xing
BACKGROUND: Growth hormone (GH)-secreting pituitary adenoma is a chronic disease characterized by excess levels of GH and insulin-like growth factor 1 (IGF-1). Based on our clinical experience and observations, we identified discordant GH and IGF-1 levels after surgery. The risk factors for this phenomenon are unclear, and individualized cure, control criteria, and management after surgery should be considered. PURPOSE: This study aims to investigate the factors affecting the discordant GH and IGF-1 levels after pituitary surgery in acromegalic patients...
March 21, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28340044/oral-ghrelin-receptor-agonist-mk-0677-increases-serum-insulin-like-growth-factor-1-in-hemodialysis-patients-a-randomized-blinded-study
#20
Garland A Campbell, James T Patrie, Bruce D Gaylinn, Michael O Thorner, Warren K Bolton
Background: . Protein-energy wasting (PEW) in end-stage renal disease (ESRD) patients is associated with increased morbidity and mortality, but options for treatment are limited. Growth hormone (GH) increases insulin-like growth factor 1 (IGF-1), with improved nutritional parameters, but must be given subcutaneously and does not provide normal GH secretion patterns. MK-0677, an oral ghrelin receptor agonist (GRA), maintains normal GH secretion and increases lean body mass in normal subjects; it has not been studied in dialysis patients, an essential step in assessing efficacy and safety prior to clinical trials...
March 3, 2017: Nephrology, Dialysis, Transplantation
keyword
keyword
66703
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"