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https://www.readbyqxmd.com/read/29344668/blocking-of-autocrine-igf-1-reduces-viability-of-human-umbilical-cord-mesenchymal-stem-cells-via-inhibition-of-the-akt-gsk-3%C3%AE-signaling-pathway
#1
Qi Wang, Fenxi Zhang, Yan Hong
Human umbilical cord mesenchymal stem cells (hUCMSCs) are able to secrete growth factors, such as hepatocyte growth factor, vascular endothelial growth factor and insulin‑like growth factor‑1 (IGF‑1). The secretion of these growth factors by transplanted hUCMSCs have been identified to stimulate the growth of the host cells in the target organs or tissues. The aim of the present study was to investigate the effect of autocrine IGF‑1 on cell viability of hUCMSCs. The expression levels of IGF‑1 and the IGF‑1 receptor (IGF‑1R) in hUCMSCs were identified using immunocytochemistry staining...
January 17, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29343614/suppressor-of-cytokine-signaling-2-socs2-deletion-protects-bone-health-of-mice-with-dss-induced-inflammatory-bowel-disease
#2
Ross Dobie, Vicky E MacRae, Chloe Pass, Elspeth M Milne, S Faisal Ahmed, Colin Farquharson
Individuals with inflammatory bowel disease (IBD) often present with poor bone health. The development of targeted therapies for this bone loss requires a fuller understanding of the underlying cellular mechanisms. Although bone loss in IBD is multifactorial, the altered sensitivity and secretion of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in IBD is understood to be a critical contributing mechanism. The expression of suppressor of cytokine signaling 2 (SOCS2), a well-established negative regulator of GH signaling, is stimulated by proinflammatory cytokines...
January 17, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29341046/reduced-growth-hormone-secretion-is-associated-with-nonalcoholic-fatty-liver-disease-in-obese-children
#3
Shuang Liang, Zhen Yu, Xiaobo Song, Yu Wang, Meng Li, Jiang Xue
The purpose of the study was to evaluate the relationship between arginine-levodopa-induced growth hormone (GH) secretion and nonalcoholic fatty liver disease (NAFLD) in obese children. This study includes a total of 84 obese and 43 normal weight children. The obese subjects are divided into two groups based on the presence or absence of NAFLD. Clinical examination, anthropometric and laboratory examinations, and liver ultrasonography are assessed for all participants. The obese group had significantly lower peak stimulated GH (p<0...
January 16, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29327586/composite-hydrogel-modified-by-igf-1c-domain-improves-stem-cell-therapy-for-limb-ischemia
#4
Xiaomin Wang, Jimin Zhang, Weilong Cui, Yuan Fang, Li Li, Shenglu Ji, Duo Mao, Tingyu Ke, Xin Yao, Dan Ding, Guowei Feng, Deling Kong
Stem cell treatment for critical limb ischemia yields a limited therapeutic effect due to cell loss and dysfunction caused by local ischemic environment. Biomimetic scaffolds emerge as ideal cell delivery vehicles for regulating cell fate via mimicking the components of stem cell niche. Herein, we prepared a bioactive hydrogel by mixing chitosan and hyaluronic acid that is immobilized with C domain peptide of IGF-1 (IGF-1C), and examined whether this hydrogel could augment stem cell survival and therapeutic potential...
January 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29321953/matrix-metalloproteinase-1-facilitates-msc-migration-via-cleavage-of-igf-2-igfbp2-complex
#5
Shou P Guan, Alan T L Lam, Jennifer P Newman, Kevin L M Chua, Catherine Y L Kok, Siao T Chong, Melvin L K Chua, Paula Y P Lam
The specific mechanism underlying the tumor tropism of human mesenchymal stem cells (MSCs) for cancer is not well defined. We previously showed that the migration potential of MSCs correlated with the expression and protease activity of matrix metalloproteinase (MMP)-1. Furthermore, highly tumor-tropic MSCs expressed higher levels of MMP-1 and insulin-like growth factor (IGF)-2 than poorly migrating MSCs. In this study, we examined the functional roles of IGF-2 and MMP-1 in mediating the tumor tropism of MSCs...
January 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29295822/runx2-overexpression-compromises-bone-quality-in-acromegalic-patients
#6
Maria Teresa Valenti, Monica Mottes, Samuele Cheri, Michela Deiana, Valentina Micheletti, Elisa Cosaro, Maria Vittoria Davì, Giuseppe Francia, Luca Dalle Carbonare
Acromegalic patients, characterized by excessive secretion of GH and IGF-1, show a high fracture risk but Bone Mineral Density is a poor predictor for bone fractures in these patients. The effects of an excess of GH/IGF1 on skeleton as well as on osteogenic progenitors, i.e. mesenchymal stem cells, have not been investigated in these patients. We aimed to elucidate the skeletal conditions of acromegalic patients by means of bone microarchitecture analysis and evaluation of MSCs osteogenic commitment. In particular, we performed histomorphometric analyses and we quantified the expression levels of the osteogenic transcription factor RUNX2 in circulating MSCs...
January 2, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29290044/aggressive-somatotrophinomas-lacking-clinical-symptoms-neurosurgical-management
#7
Mario Giordano, Amir Samii, Rudolf Fahlbusch
We report our experience about somatotrophinomas without clinical manifestation of acromegaly having radiological- and surgical-verified invasion of the cavernous sinus. We present the clinical, radiological and hormonal status of three patients affected by invasive GH-secreting pituitary adenomas without clinical signs and symptoms of acromegaly with elevation of serum IGF-1 from a series of 142 pituitary adenomas operated in our institute with the aid of intraoperative magnetic resonance imaging (MRI). Total tumor removal was possible in two of the three cases; the patients show normal hormonal status and no recurrence at long-term follow-up...
December 30, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29278515/pegvisomant-primed-growth-hormone-gh-stimulation-test-is-useful-in-identifying-true-gh-deficient-children
#8
Giorgio Radetti, Heba H Elsedfy, Randa Khalaf, Cristina Meazza, Sara Pagani, Mohamed El Kholy, Riccardo Albertini, Anna Maria De Stefano, Antonella Navarra, Annalisa De Silvestri, Mauro Bozzola
OBJECTIVE: Provocative stimulation tests for growth hormone (GH) assessment have poor reproducibility and can often elicit false positive results in normal children. The aim of our study was to confirm the capability of pegvisomant as an enhancer of GH secretion in unmasking false-positive results in short children (height <-2.0 standard deviation score, SDS) undergoing GH testing. DESIGN: A prospective study was conducted between March and August 2016. Twenty short children (10 males and 10 females), aged 4...
July 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29274819/proliferation-metabolic-activity-and-adipogenic-differentiation-of-human-preadipocytes-exposed-to-two-surfactants-in-vitro
#9
Tim Ruhl, Gabriele Storti, Norbert Pallua
Fat grafting is a pivotal technique for tissue repair. Adipose stromal cells, including preadipocytes, play a major role in the regenerative effects attributed to fat grafting. But the benefits are impaired by the low survival of the graft due to mechanical stress during harvesting, hypoxia and nutrient deprivation. Non-ionic surfactant molecules demonstrated their efficacy in preventing and repairing mechanical damage on the cellular membrane, but it is poorly understood if and how they affect cellular viability, proliferation and differentiation...
December 21, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29259475/impact-of-metabolic-disorders-on-prostate-cancer-growth-androgen-and-insulin-resistance-perspectives
#10
REVIEW
Tashihiko Yanase, Takako Kawanami, Tomoko Tanaka, Makito Tanabe, Takashi Nomiyama
Background: A high prevalence of cancers in metabolic disorders, like metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM), recently has been noted, including prostate cancer (PC), which is androgen-sensitive. However, the pathological relationship among testosterone and insulin and insulin-like growth factor (IGF)-1 signaling in relation to MetS and T2DM with PC remains unclear. Methods: Papers were reviewed, including those by the authors. Results: In MetS or the initial stage of T2DM accompanying insulin resistance, insulin and IGF-1 signaling could be essential for PC growth...
July 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29242356/pre-treatment-growth-and-igf-i-deficiency-as-main-predictors-of-response-to-growth-hormone-therapy-in-neural-models
#11
Urszula Smyczynska, Joanna Smyczynska, Maciej Hilczer, Renata Stawerska, Ryszard Tadeusiewicz, Andrzej Lewinski
Mathematical models have been applied in prediction of growth hormone treatment effectiveness in children since the end of 1990s. Usually they were multiple linear regression models, however there are also examples derived by empirical non-linear methods. Proposed solution consists in application of machine learning technique - artificial neural networks - to analyse this problem. This new methodology, contrary to previous ones, allows detection of both linear and non-linear dependencies without assuming their character a priori...
December 14, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29238626/c-kit-positive-cardiac-outgrowth-cells-demonstrate-better-ability-for-cardiac-recovery-against-ischemic-myopathy
#12
Chuan Li, Satoshi Matsushita, Zhengqing Li, Jianjun Guan, Atsushi Amano
Objective: Resident cardiac stem cells are expected to be a therapeutic option for patients who suffer from severe heart failure. However, uncertainty remains over whether sorting cells for c-kit, a stem cell marker, improves therapeutic outcomes. Materials and methods: Cardiac outgrowth cells cultured from explants of rat heart atrium were sorted according to their positivity (+) or negativity (-) for c-kit. These cells were exposed to hypoxia for 3 d, and subsequently harvested for mRNA expression measurement...
October 2017: Journal of Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29233485/body-fat-affects-mouse-reproduction-ovarian-hormone-release-and-response-to-follicular-stimulating-hormone
#13
Alexander V Sirotkin, Dušan Fabian, Janka Babeľová Kubandová, Radoslava Vlčková, Saleh Alwasel, Abdel Halim Harrath
We investigated the effects of body fat content on mouse fecundity, ovarian hormone release, and their response to follicle stimulation hormone (FSH). 4 types of females were produced: lean (group 1), normal (group 2), slightly fat (group 3), and significantly fat (group 4). The body weights, fat content, fertility rate, embryo number produced, retarded and degenerated embryo percentage, the release of progesterone (P4), testosterone (T), and insulin-like growth factor I (IGF-I) by isolated ovaries cultured with and without FSH (1...
December 7, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/29222208/hypersomatotropism-induced-secondary-polycythaemia-leading-to-spontaneous-pituitary-apoplexy-resulting-in-cure-of-acromegaly-and-remission-of-polycythaemia-the-virtuous-circle
#14
Shinjan Patra, Sugata Narayan Biswas, Joydip Datta, Partha Pratim Chakraborty
A young man with subtle clinical features suggestive of hypersomatotropism presented with acute-onset severe headache. Relevant investigations confirmed polycythaemia and growth hormone (GH)-secreting pituitary macroadenoma with apoplexy. Secondary polycythaemia and myeloproliferative disorders were ruled out. At follow-up after 3 months, resolution of polycythaemia and acromegaly was observed, evident on normal haemoglobin levels, a normocellular marrow, and normal insulin-like growth factor-1 (IGF-1) with glucose-suppressed GH levels...
December 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29217764/radiotherapy-activated-cancer-associated-fibroblasts-promote-tumor-progression-through-paracrine-igf-1r-activation
#15
Joke Tommelein, Elly De Vlieghere, Laurine Verset, Elodie Melsens, Justine Leenders, Benedicte Descamps, Annelies Debucquoy, Christian Vanhove, Patrick Pauwels, Christian P Gespach, Anne Vral, Astrid De Boeck, Karin Haustermans, Pascal de Tullio, Wim Ceelen, Pieter Demetter, Tom Boterberg, Marc Bracke, Olivier De Wever
Preoperative radiotherapy (RT) is a mainstay in the management of rectal cancer (RC), a tumor characterized by desmoplastic stroma containing cancer-associated fibroblasts (CAF). Although CAF are abundantly present, the effects of RT to CAF and its impact on cancer cells are unknown. We evaluated the damage responses of CAF to RT and investigated changes in colorectal cancer (CRC) cell growth, transcriptome, metabolome, and kinome in response to paracrine signals emerging from irradiated CAF. RT to CAF induced DNA damage, p53 activation, cell cycle arrest, and secretion of paracrine mediators including insulin-like growth factor-1 (IGF-1)...
December 7, 2017: Cancer Research
https://www.readbyqxmd.com/read/29208686/effects-of-growth-hormone-administration-on-luteinizing-hormone-secretion-in-healthy-older-men-and-women
#16
Ranganath Muniyappa, Shannon D Sullivan, Sri Harsha Tella, Brent S Abel, S Mitchell Harman, Marc R Blackman
The known interactions between the somatotropic and hypothalamic-pituitary-gonadal (HPG) axes have not been well delineated in older individuals. Aging-associated decline in insulin like growth factor-1 (IGF-1) levels has been proposed to play a role in reproductive senescence in animals. However, the effects of GH on LH secretion are unknown in older individuals. Our objective was to determine whether GH modulates LH secretion or levels of sex steroids (SS) in healthy older (ages 65-88 years) men (n = 24) and women (n = 24) with low-normal plasma IGF-1 levels...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29179911/growth-hormone-and-insulin-like-growth-factor-1-secretions-in-eating-disorders-correlations-with-psychopathological-aspects-of-the-disorders
#17
Francesca Brambilla, Paolo Santonastaso, Lorenza Caregaro, Angela Favaro
Hormonal alterations in Eating Disorders (ED) may result from the biochemical stress of malnutrition/starvation. The correlations between some hormonal impairments, particularly of the somatotropic axis, and the psychopathological aspects of ED are still undefined. We measured the plasma concentrations of the somatotropic hormone (GH) and the insulin-like growth factor-1 (IGF-1) in 136 patients with various forms of ED, 65 with restricted Anorexia Nervosa (ANR), 19 with bingeing-purging Anorexia Nervosa (ANBP), 12 with purging-non binging Anorexia Nervosa (ANP), 26 with Bulimia Nervosa (BN), 8 with ED not otherwise specified-anorexic type (EDNOS-AN), 7 with ED not otherwise specified-bulimic type (EDNOS-BN) and in 30 healthy controls...
July 26, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29168114/parathyroid-hormone-in-surgery-induced-weight-loss-no-glucometabolic-effects-but-potential-adaptive-response-to-skeletal-loading
#18
Valeria Guglielmi, Alfonso Bellia, Paolo Gentileschi, Mauro Lombardo, Monica D'Adamo, Davide Lauro, Paolo Sbraccia
PURPOSE: Increased parathyroid hormone (PTH) is commonly associated with obesity, and its role in the pathogenesis of obesity-related glucometabolic abnormalities is uncertain. We aimed to explore the relationships of PTH with glucose/insulin homeostasis parameters before and after bariatric surgery-induced weight loss, and whether they depend or not on 25-hydroxyvitamin D (25OHD) status. METHODS: We included 42 subjects (27 women, aged 40 ± 5 years, BMI 48...
November 22, 2017: Endocrine
https://www.readbyqxmd.com/read/29138430/extracellular-vesicles-derived-from-mscs-activates-dermal-papilla-cell-in-vitro-and-promotes-hair-follicle-conversion-from-telogen-to-anagen-in-mice
#19
Ramya Lakshmi Rajendran, Prakash Gangadaran, Soon Sun Bak, Ji Min Oh, Senthilkumar Kalimuthu, Ho Won Lee, Se Hwan Baek, Liya Zhu, Young Kwan Sung, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
Hair loss is a common medical problem. In this study, we investigated the proliferation, migration, and growth factor expression of human dermal papilla (DP) cells in the presence or absence of treatment with mesenchymal stem cell extracellular vesicles (MSC-EVs). In addition, we tested the efficacy of MSC-EV treatment on hair growth in an animal model. MSC-EV treatment increased DP cell proliferation and migration, and elevated the levels of Bcl-2, phosphorylated Akt and ERK. In addition; DP cells treated with MSC-EVs displayed increased expression and secretion of VEGF and IGF-1...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29131315/txndc5-contributes-to-rheumatoid-arthritis-by-down-regulating-igfbp1-expression
#20
Jian Li, Bing Xu, Changsun Wu, Xinfeng Yan, Lei Zhang, Xiaotian Chang
The thioredoxin domain-containing 5 (TXNDC5) gene is associated with susceptibility to rheumatoid arthritis (RA) and exhibits increased expression in the synovial tissues. TXNDC5 is also strongly associated with diabetes, a metabolic disease characterized by interrupted insulin signaling. This study investigated whether TXNDC5 contributes to RA via the insulin signaling pathway. In the study, RA synovial fibroblast-like cells (RASFs) transfected with an anti-TXNDC5 small interfering RNA (siRNA) were analyzed with an Insulin Signaling Pathway RT(2) Profiler PCR Array and an Insulin Resistance RT(2) Profiler PCR Array...
November 13, 2017: Clinical and Experimental Immunology
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