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igf1 secretion

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https://www.readbyqxmd.com/read/29910227/postoperative-growth-hormone-dynamics-in-clinically-nonfunctioning-pituitary-adenoma
#1
Nobuyuki Kobayashi, Mitsuo Yamaguchi-Okada, Kentaro Horiguchi, Noriaki Fukuhara, Hiroshi Nishioka, Shozo Yamada
Growth hormone deficiency (GHD) is an endocrine disorder characterized by insufficient production of growth hormone (GH). Non-functioning pituitary adenoma (NFPA) is one of common causes of GHD. Although most patients with NFPA have transsphenoidal surgery, the time-dependent changes in GH after operation have yet to be investigated. In this study, we analyzed patients with NFPAs that underwent transsphenoidal surgery. Postoperatively, GH secretion was evaluated in response to GH-releasing peptide-2 (GHRP2) infusion...
June 15, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29897817/persistent-disruption-of-lateral-junctional-complexes-and-actin-cytoskeleton-in-parotid-salivary-glands-following-radiation-treatment
#2
Wen Yu Wong, Maricela Pier, Kirsten H Limesand
Xerostomia and hyposalivation are debilitating side effects for patients treated with ionizing radiation for head and neck cancer. Despite technological advances, collateral damage to the salivary glands remains a significant problem for patients and severely diminishes their quality of life. During the wound healing process, restoration of junctional contacts is necessary to maintain polarity, structural integrity, and orientation cues for secretion. However, little is known about whether these structural molecules are impacted following radiation damage and more importantly during tissue restoration...
June 13, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29758340/traditional-mongolian-medicine-eerdun-wurile-improves-stroke-recovery-through-regulation-of-gene-expression-in-rat-brain
#3
Saren Gaowa, Narisi Bao, Man Da, Qiburi Qiburi, Tsogzolmaa Ganbold, Lu Chen, Altanzul Altangerel, Temuqile Temuqile, Huricha Baigude
ETHNOPHARMACOLOGICAL RELEVANCE: Eerdun Wurile (EW) is one of the key Mongolian medicines for treatment of neurological and cardiological disorders. EW is ranked most regularly used Mongolian medicine in clinic. Components of EW which mainly originate from natural products are well defined and are unique to Mongolian medicine. AIM OF THE STUDY: Although the recipe of EW contains known neuroactive chemicals originated from plants, its mechanism of action has never been elucidated at molecular level...
May 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29739870/pregnancy-associated-plasma-protein-aa-pappaa-regulates-photoreceptor-synaptic-development-to-mediate-visually-guided-behavior
#4
Andrew H Miller, Hollis B Howe, Bryan M Krause, Scott A Friedle, Matthew I Banks, Brian D Perkins, Marc A Wolman
To guide behavior, sensory systems detect the onset and offset of stimuli and process these distinct inputs via parallel pathways. In the retina, this strategy is implemented by splitting neural signals for light onset and offset via synapses connecting photoreceptors to ON and OFF bipolar cells, respectively. It remains poorly understood which molecular cues establish the architecture of this synaptic configuration to split light onset and offset signals. A mutant with reduced synapses between photoreceptors and one bipolar cell type, but not the other, could reveal a critical cue...
May 8, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29697760/insulinlike-growth-factor-1-gene-variation-in-vertebrates
#5
Peter Rotwein
IGF1-a small, single-chain, secreted peptide in mammals-is essential for normal somatic growth and is involved in a variety of other physiological and pathophysiological processes. IGF1 expression appears to be controlled by several different signaling mechanisms in mammals, with GH playing a key role by activating an inducible transcriptional pathway via the Jak2 protein kinase and the Stat5b transcription factor. Here, to understand aspects of Igf1 gene regulation over a substantially longer timeline than is discernible in mammals, Igf1 genes have been examined in 21 different nonmammalian vertebrates representing five different classes and ranging over ∼500 million years of evolutionary history...
June 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29672904/growth-hormone-insulin-like-growth-factor-1-axis-hyperactivity-on-bone-fibrous-dysplasia-in-mccune-albright-syndrome
#6
Daniele Tessaris, Alison M Boyce, Margaret Zacharin, Patrizia Matarazzo, Roberto Lala, Luisa De Sanctis, Michael T Collins
CONTEXT: In fibrous dysplasia (BFD), normal bone and bone marrow are replaced by fibro-osseous tissue, leading to fracture, deformity and pain. BFD may be isolated, or in association with cutaneous hyperpigmentation and/or hyperfunctioning endocrinopathies, termed McCune-Albright syndrome (MAS). GH hypersecretion has been described in 10%-20% of MAS-BFD patients. Aim of the study was to determine the impact of GH-insulin like growth factor 1 (IGF1) axis hyperactivity on MAS-BFD morbidities and the efficacy of GH excess therapy...
April 19, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29535813/the-crosstalk-between-breast-carcinoma-associated-fibroblasts-and-cancer-cells-promotes-rhoa-dependent-invasion-via-igf-1-and-pai-1
#7
Julien Daubriac, Shiwei Han, Jelena Grahovac, Eve Smith, Abdel Hosein, Marguerite Buchanan, Mark Basik, Yves Boucher
Carcinoma-associated fibroblasts (CAFs) can remodel the extracellular matrix to promote cancer cell invasion, but the paracrine signaling between CAFs and cancer cells that regulates tumor cell migration remains to be identified. To determine how the interaction between CAFs and cancer cells modulates the invasiveness of cancer cells, we developed a 3-dimensional co-culture model composed of breast cancer (BC) MDA-MB-231 cell spheroids embedded in a collagen gel with and without CAFs. We found that the crosstalk between CAFs and cancer cells promotes invasion by stimulating the scattering of MDA-MB-231 cells, which was dependent on RhoA/ROCK/phospho MLC signaling in cancer cells but independent of RhoA in CAFs...
February 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29525066/-diffuse-hypertrichosis-revealing-non-classical-congenital-adrenal-hyperplasia
#8
C Berthin, P Sibilia, J Martins-Hericher, A Donzeau, L Martin
BACKGROUND: Non-classical congenital adrenal hyperplasia (NC-CAH) is a recessive autosomal disease caused by a deficiency of adrenal steroidogenesis enzymes. It must be distinguished from classical CAH, either simple virilising or salt-wasting, diagnosed during the neonatal period and responsible for potentially lethal disorders of sexual differentiation. NC-CAH presents a simpler and less specific clinical picture. Herein, we present two cases comprising twin girls consulting for diffuse hypertrichosis...
April 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29478375/engineering-the-second-generation-of-therapeutic-cells-with-enhanced-targeting-of-injured-tissues
#9
Mark L Wang, Pedro K Beredjiklian, Andrzej Steplewski, Jolanta Fertala, Andrzej Fertala
Experimental approaches to improving tissue repair utilize cells and growth factors needed to restore the architecture and function of damaged tissues and organs. Key limitations of these approaches include poor delivery of therapeutic cells and growth factors into injury sites, as well as their short-term retention in target areas. In our earlier studies, we demonstrated that artificial collagen-specific anchor (ACSA) expressed on the surface of therapeutic cells directs them into collagen-rich sites of injury...
March 28, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29398030/high-concentrations-of-fatty-acids-and-%C3%AE-hydroxybutyrate-impair-the-growth-hormone-mediated-hepatic-jak2-stat5-pathway-in-clinically-ketotic-cows
#10
Xiliang Du, Yiwei Zhu, Zhicheng Peng, Yuanxu Cui, Qiang Zhang, Zhen Shi, Yuan Guan, Xueying Sha, Taiyu Shen, Yuchen Yang, Xiaobing Li, Zhe Wang, Xinwei Li, Guowen Liu
The hepatic growth hormone (GH)-insulin-like growth factor (IGF)-I axis is essential for regulating intrahepatic lipid metabolism. Ketotic cows are characterized by high blood concentrations of fatty acids and β-hydroxybutyrate (BHB), which display lipotoxicity. The aim of this study was to investigate changes in the hepatic GH-IGF-I axis in ketotic cows and to determine the effects of fatty acids and BHB on the GH-IGF-I axis in calf hepatocytes. Liver and blood samples were collected from healthy (n = 15) and clinically ketotic (n = 15) cows...
April 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29383833/adipose-derived-stem-cells-decrease-cardiomyocyte-damage-induced-by-porphyromonas-gingivalis-endotoxin-through-suppressing-hypertrophy-apoptosis-fibrosis-and-mapk-markers
#11
Tung-Sheng Chen, Chia-Hua Kuo, Sarnai Battsengel, Lung-Fa Pan, Cecilia Hsuan Day, Chia-Yao Shen, Li-Chin Chung, V Vijaya Padma, Chen-Kai Yao, Yueh-Min Lin, Chih-Yang Huang
Heart failure is one of the complications related to periodontal disease. In addition to drugs or herbal medicines, stem cell therapy shows potential in the treatment of cardiomyopathy. This study investigates if stem cells exhibit beneficial effects on cardiomyocyte damage induced by porphyromonas gingivalis endotoxin (Pg-LPS). From the experimental results we find that Pg-LPS reduce cardiomyocyte viability via the activation of apoptosis, hypertrophy, fibrosis and MAPK signaling. Pg-LPS damaged cardiomyocytes co-cultured with adipose-derived stem cells (ADSC) increases cardiomyocyte viability through suppressing the pathological markers described above...
April 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29368588/vitamin-d-in-children-with-growth-hormone-deficiency-due-to-pituitary-stalk-interruption-syndrome
#12
Cécile Delecroix, Raja Brauner, Jean-Claude Souberbielle
BACKGROUND: Recent studies have shown a relationship between vitamin D status and growth hormone (GH) and insulin-like growth factor 1 (IGF1). The objective of this study was to assess vitamin D status in children with GH deficiency due to pituitary stalk interruption syndrome (PSIS) and to investigate the relationship between 25-hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25 (OH) 2D) serum levels and patient characteristics. METHODS: A retrospective single-center study of 25OHD and 1,25(OH)2D serum concentrations in 50 children with PSIS at the initial evaluation before treatment...
January 24, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29352310/leishmania-proteophosphoglycans-regurgitated-from-infected-sand-flies-accelerate-dermal-wound-repair-and-exacerbate-leishmaniasis-via-insulin-like-growth-factor-1-dependent-signalling
#13
Emilie Giraud, Tereza Lestinova, Tamsyn Derrick, Oihane Martin, Rod J Dillon, Petr Volf, Ingrid Műller, Paul A Bates, Matthew E Rogers
Leishmania parasites are transmitted to vertebrate hosts by female phlebotomine sand flies as they bloodfeed by lacerating the upper capillaries of the dermis with their barbed mouthparts. In the sand fly midgut secreted proteophosphoglycans from Leishmania form a biological plug known as the promastigote secretory gel (PSG), which blocks the gut and facilitates the regurgitation of infective parasites. The interaction between the wound created by the sand fly bite and PSG is not known. Here we nanoinjected a sand fly egested dose of PSG into BALB/c mouse skin that lead to the differential expression of 7,907 transcripts...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29295822/runx2-overexpression-compromises-bone-quality-in-acromegalic-patients
#14
Maria Teresa Valenti, Monica Mottes, Samuele Cheri, Michela Deiana, Valentina Micheletti, Elisa Cosaro, Maria Vittoria Davì, Giuseppe Francia, Luca Dalle Carbonare
Acromegalic patients, characterized by excessive secretion of GH and IGF-1, show a high fracture risk but bone mineral density is a poor predictor for bone fractures in these patients. The effects of an excess of GH/IGF1 on skeleton as well as on osteogenic progenitors, i.e. mesenchymal stem cells, have not been investigated in these patients. We aimed to elucidate the skeletal conditions of acromegalic patients by means of bone microarchitecture analysis and evaluation of MSCs osteogenic commitment. In particular, we performed histomorphometric analyses, and we quantified the expression levels of the osteogenic transcription factor RUNX2 in circulating MSCs...
March 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29240807/diversification-of-the-insulin-like-growth-factor-1-gene-in-mammals
#15
Peter Rotwein
Insulin-like growth factor 1 (IGF1), a small, secreted peptide growth factor, is involved in a variety of physiological and patho-physiological processes, including somatic growth, tissue repair, and metabolism of carbohydrates, proteins, and lipids. IGF1 gene expression appears to be controlled by several different signaling cascades in the few species in which it has been evaluated, with growth hormone playing a major role by activating a pathway involving the Stat5b transcription factor. Here, genes encoding IGF1 have been evaluated in 25 different mammalian species representing 15 different orders and ranging over ~180 million years of evolutionary diversification...
2017: PloS One
https://www.readbyqxmd.com/read/29101331/conventional-and-unconventional-secretory-proteins-expressed-with-silkworm-bombyxin-signal-peptide-display-functional-fidelity
#16
Sungjo Park, D Kent Arrell, Santiago Reyes, Enoch Y Park, Andre Terzic
Growth factors are signaling molecules which orchestrate cell growth, proliferation and differentiation. The majority are secreted proteins, exported through the classical endoplasmic reticulum (ER)/Golgi-dependent pathway, but a few are released by unconventional ER/Golgi-independent means. Human fibroblast growth factor 2 (FGF2) and insulin-like growth factor 1 (IGF1), are canonical prototypes secreted by the unconventional and conventional pathway, respectively. We herein examined whether expression of these two growth factors in the Bombyx mori nucleopolyhedrovirus (BmNPV)-based silkworm expression system with its innate signal peptide, bombyxin, secures structural homogeneity at the signal peptide cleavage site regardless of the native secretory route...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29080043/pi3k-akt-mtor-pathway-involvement-in-regulating-growth-hormone-secretion-in-a-rat-pituitary-adenoma-cell-line
#17
Carmelina Di Pasquale, Erica Gentilin, Simona Falletta, Mariaenrica Bellio, Mattia Buratto, Ettore Degli Uberti, Maria Chiara Zatelli
PURPOSE: Insulin-like growth factor 1 (IGF1) controls growth hormone (GH) secretion via a negative feed-back loop that may disclose novel mechanisms possibly useful to control GH hyper-secretion. Our aim was to understand whether PI3K/Akt/mTOR pathway is involved in IGF1 negative feedback on GH secretion. METHODS: Cell viability, GH secretion, Akt, and Erk 1/2 phosphorylation levels in the rat GH3 cell line were assessed under treatment with IGF1 and/or everolimus, an mTOR inhitior...
May 2018: Endocrine
https://www.readbyqxmd.com/read/29039494/internal-driving-factors-leading-to-extrahepatic-manifestation-of-the-hepatitis%C3%A2-c-virus-infection
#18
Zhou-Yi Wu, Jian-Rui Li, Meng-Hao Huang, Jun-Jun Cheng, Hu Li, Jin-Hua Chen, Xiao-Qin Lv, Zong-Gen Peng, Jian-Dong Jiang
The hepatitis C virus (HCV) infection is associated with various extrahepatic manifestations, which are correlated with poor outcomes, and thus increase the morbidity and mortality of chronic hepatitis C (CHC). Therefore, understanding the internal linkages between systemic manifestations and HCV infection is helpful for treatment of CHC. Yet, the mechanism by which the virus evokes the systemic diseases remains to be elucidated. In the present study, using gene set enrichment analysis (GSEA) and signaling pathway impact analysis (SPIA), a comprehensive analysis of microarray data of mRNAs was conducted in HCV-infected and -uninfected Huh7...
October 5, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29017078/fgf1-and-igf1-conditioned-3d-culture-system-promoted-the-amplification-and-cancer-stemness-of-lung-cancer-cells
#19
Pengpeng Liu, Rui Zhang, Wenwen Yu, Yingnan Ye, Yanan Cheng, Lei Han, Li Dong, Yongzi Chen, Xiyin Wei, Jinpu Yu
Lung cancer stem cells (LCSCs) are considered as the cellular origins of metastasis and relapse of lung cancer. However, routine two-dimensional culture system (2D-culture) hardly mimics the growth and functions of LCSCs in vivo and therefore significantly decreases the stemness activity of LCSCs. In this study, we constructed a special BME-based three-dimensional culture system (3D-culture) to amplify LCSCs in human lung adenocarcinoma cell line A549 cells and found 3D-culture promoted the enrichment and amplification of LCSCs in A549 cells displaying higher proliferation potential and invasion activity, but lower apoptosis...
December 2017: Biomaterials
https://www.readbyqxmd.com/read/28926092/key-genes-regulating-the-liposecretion-process-of-mature-adipocytes
#20
REVIEW
Giulia Maurizi, Tiina Petäistö, Angela Maurizi, Lucio Della Guardia
White mature adipocytes (MAs) are plastic cells able to reversibly transdifferentiate toward fibroblast-like cells maintaining stem cell gene signatures. The main morphologic aspect of this transdifferentiation process, called liposecretion, is the secretion of large lipid droplets and the development of organelles necessary for exocrine secretion. There is a considerable interest in the adipocyte plastic properties involving liposecretion process, but the molecular details are incompletely explored. This review analyzes the gene expression of MAs isolated from human subcutaneous fat tissue with respect to bone marrow (BM)-derived mesenchymal stem cells (MSC) focusing on gene regulatory pathways involved into cellular morphology changes, cellular proliferation and transports of molecules through the membrane, suggesting potential ways to guide liposecretion...
May 2018: Journal of Cellular Physiology
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