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https://www.readbyqxmd.com/read/29778960/rapid-colorimetric-detection-of-p53-protein-function-using-dna-gold-nanoconjugates-with-applications-for-drug-discovery-and-cancer-diagnostics
#1
Enock Assah, Walter Goh, Xin Ting Zheng, Ting Xiang Lim, Jun Li, David Lane, Farid Ghadessy, Yen Nee Tan
The tumor suppressor protein p53 plays a central role in preventing cancer through interaction with DNA response elements (REs) to regulate target gene expression in cells. Due to its significance in cancer biology, relentless efforts have been directed toward understanding p53-DNA interactions for the development of cancer therapeutics and diagnostics. In this paper, we report a rapid, label-free and versatile colorimetric assay to detect wildtype p53 DNA-binding function in complex solutions. The assay design is based on a concept that alters interparticle-distances between RE-AuNPs from a crosslinking effect induced through tetramerization of wildtype p53 protein (p53-WT) upon binding to canonical DNA motifs modified on gold nanoparticles (RE-AuNPs)...
May 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29778626/factors-underlying-risk-taking-in-heroin-dependent-individuals-feedback-processing-and-environmental-contingencies
#2
Daniella M Saleme, Bruno Kluwe-Schiavon, Abdrabo Soliman, Błażej Misiak, Dorota Frydecka, Ahmed A Moustafa
Evidence suggests that factors influencing risk-taking include whether decisions are made based on emotions (affective systems) or cognitions (deliberative systems), the processing of feedback (e.g., deciding to attend a rehabilitation facility for opioid addiction treatment after an intervention held by a family member), and attention to environmental contingencies (e.g., considering the probability of an outcome such as the likelihood of contracting tetanus from a shared needle; or the gains and losses associated with a decision, such as the benefits and costs of taking drugs)...
May 17, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29776749/determinants-of-cost-of-routine-immunization-programme-in-india
#3
Susmita Chatterjee, Arpita Ghosh, Palash Das, Nicolas A Menzies, Ramanan Laxminarayan
The costs of delivering routine immunization services in India vary widely across facilities, districts and states. Understanding the factors influencing this cost variation could help predict future immunization costs and suggest approaches for improving the efficiency of service provision. We examined determinants of facility cost for immunization services based on a nationally representative sample of sub-centres and primary health centres (99 and 89 facilities, respectively) by regressing logged total facility costs, both including and excluding vaccine cost, against several explanatory variables...
May 15, 2018: Vaccine
https://www.readbyqxmd.com/read/29776671/guidelines-on-diabetic-eye-care-the-international-council-of-ophthalmology-recommendations-for-screening-follow-up-referral-and-treatment-based-on-resource-settings
#4
REVIEW
Tien Y Wong, Jennifer Sun, Ryo Kawasaki, Paisan Ruamviboonsuk, Neeru Gupta, Van Charles Lansingh, Mauricio Maia, Wanjiku Mathenge, Sunil Moreker, Maji M K Muqit, Serge Resnikoff, Juan Verdaguer, Peiquan Zhao, Frederick Ferris, Lloyd P Aiello, Hugh R Taylor
Diabetes mellitus (DM) is a global epidemic and affects populations in both developing and developed countries, with differing health care and resource levels. Diabetic retinopathy (DR) is a major complication of DM and a leading cause of vision loss in working middle-aged adults. Vision loss from DR can be prevented with broad-level public health strategies, but these need to be tailored to a country's and population's resource setting. Designing DR screening programs, with appropriate and timely referral to facilities with trained eye care professionals, and using cost-effective treatment for vision-threatening levels of DR can prevent vision loss...
May 15, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29775857/enzyme-free-homogeneous-electrochemical-biosensor-for-dna-assay-using-toehold-triggered-strand-displacement-reaction-coupled-with-host-guest-recognition-of-fe-3-o-4-sio-2-%C3%AE-cd-nanocomposites
#5
Jingjing Jiang, Xinyi Lin, Dong Ding, Guowang Diao
Taking advantages of the toehold-triggered strand displacement reaction (TSDR) and host-guest interaction of β-cyclodextrin (β-CD), a facile enzyme-free and homogeneous electrochemical sensing strategy was designed for the sensitive assay of target DNA using Fe3 O4 @SiO2 @β-CD nanocomposites and ferrocene-labeled hairpin DNA (H-1) as the capture and electrochemical probes, respectively. Upon addition of target molecule, the initiated TSDR process induced the conformational change of H-1, and subsequently stimulated the dynamic assembly of assist probes (A-1 and A-2) to generate H-1:A-1:A-2 duplex along with the release of target sequence...
April 17, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29774346/dft-insight-into-the-effect-of-potassium-on-the-adsorption-activation-and-dissociation-of-co-2-over-fe-based-catalysts
#6
Xiaowa Nie, Linlin Meng, Haozhi Wang, Yonggang Chen, Xinwen Guo, Chunshan Song
Catalytic conversion of CO2 including hydrogenation has attracted great attention as a method for chemical fixation of CO2 in combination with other techniques such as CO2 capture and storage. Potassium is a well-known promotor for many industrial catalytic processes such as in Fischer-Tropsch synthesis. In this work, we performed density functional theory (DFT) calculations to investigate the effect of potassium on the adsorption, activation, and dissociation of CO2 over Fe(100), Fe5C2(510) and Fe3O4(111) surfaces...
May 18, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29774065/catalytic-hairpin-assembly-gel-assay-for-multiple-and-sensitive-microrna-detection
#7
Wenhao Dai, Jing Zhang, Xiangdan Meng, Jie He, Kai Zhang, Yu Cao, Dongdong Wang, Haifeng Dong, Xueji Zhang
As important modulators of gene expression, microRNAs (miRNAs) have been identified as promising biomarkers with powerful predictive value in diagnosis and prognosis for several diseases, especially for cancers. Here we report a facile, multiple and sensitive miRNA detection method that uses conventional gel electrophoresis and catalytic hairpin assembly (CHA) system without any complex nanomaterials or enzymatic amplification. Methods: In this study, three pairs of hairpin probes are rationally designed with thermodynamically and kinetically preferable feasibility for the CHA process...
2018: Theranostics
https://www.readbyqxmd.com/read/29773399/dual-physically-crosslinked-healable-polyacrylamide-cellulose-nanofibers-nanocomposite-hydrogels-with-excellent-mechanical-properties
#8
Jiabao Niu, Jianquan Wang, Xiaofu Dai, Ziqiang Shao, Xiaonan Huang
To develop healable hydrogels with excellent mechanical properties is still a challenge topic. In this study, a novel class of physically crosslinked polyacrylamide based nanocomposite hydrogels reinforced with cellulose nanofibers (CNF) were fabricated using radical polymerization, followed by further strengthening through ferric ions via strong ionic coordination interactions between Fe3+ and carboxyls on CNF surfaces. Then the obtained gels were characterized by FTIR, tensile and compressive measurements as well as healing experiments...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29773355/pain-assessment-and-management-by-nurses-in-a-geriatric-setting-discrepancies-between-guidelines-and-documented-practice
#9
Irit Shahar, Gad Mendelson, Shlomit Gerbi, Merav Ben Natan
Pain is a common subjective symptom among older adults in general and among older adult residents in long-term geriatric facilities in particular. Pain diminishes older adults' quality of life and may impair their ability to recover from various illnesses. Therefore, the Israeli Ministry of Health has issued guidelines on effectively assessing and treating pain in this population. To examine discrepancies between the Ministry of Health's pain assessment guidelines and documented practice by nursing staff at a long-term geriatric care facility and whether these discrepancies correlate to characteristics of the nurses, the wards, and the patients' characteristics...
May 14, 2018: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29772413/self-templating-synthesis-of-hollow-copper-tungstate-spheres-as-adsorbents-for-dye-removal
#10
Jing-Feng Li, Yibo Chen, Zhu Wang, Zhao-Qing Liu
In spite of recent progress in developing hollow micro/nanostructures, the synthesis of three-dimensional adsorbents with high adsorption efficiency and capability on the basis of these structures still remains a great challenge. Herein, we demonstrate a facile hydrothermal strategy to synthesize uniformly dispersed hollow CuWO4 spheres. The as-prepared CuWO4 spheres with unique mesoporous structure show favorable selective adsorption for cationic dyes and good recyclability. The adsorption capacity of hollow CuWO4 towards methylene blue (MB) reaches 59...
May 11, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29772262/an-international-survey-of-cleaning-and-disinfection-practices-in-the-healthcare-environment
#11
Nikki Kenters, Thomas Gottlieb, Joost Hopman, Shaheen Mehtar, Marin L Schweizer, Ermira Tartari, E G W Huijskens, Andreas Voss
BACKGROUND: Antimicrobial resistance has become an urgent global health priority. Basic hygiene practices and cleaning and disinfection of the hospital environment are key in preventing pathogen cross-transmission. AIM: To our knowledge no studies have assessed the worldwide differences in cleaning and disinfection practices in healthcare facilities. The electronic survey described here was developed in order to evaluate differences in healthcare facility cleaning practices around the world...
May 14, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29770570/an-adaptive-environmental-effects-monitoring-framework-for-assessing-the-influences-of-liquid-effluents-on-benthos-water-and-sediments-in-aquatic-receiving-environments
#12
REVIEW
Keith M Somers, Bruce W Kilgour, Kelly R Munkittrick, Tim J Arciszewski
Environmental effects monitoring (EEM) has been traditionally used to evaluate the effects of existing facilities discharging liquid effluents into natural receiving waters in Canada. EEM also has the potential to provide feedback to an ongoing project in an adaptive management context, and can inform the design of future projects. EEM, consequently, can and should also be used to test the predictions of effects related to new projects. Despite EEM's potential for widespread applicability, challenges related to the effective implementation of EEM include the use of appropriate study designs, as well as to the adoption of tiers for increasing or decreasing monitoring intensity...
May 16, 2018: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/29769434/virtual-reality-based-adaptive-dose-assessment-method-for-arbitrary-geometries-in-nuclear-facility-decommissioning
#13
Yong-Kuo Liu, Nan Chao, Hong Xia, Min-Jun Peng, Abiodun Ayodeji
This paper presents an improved and efficient virtual reality-based adaptive dose assessment method (VRBAM) applicable to the cutting and dismantling tasks in nuclear facility decommissioning. The method combines the modeling strength of virtual reality with the flexibility of adaptive technology. The initial geometry is designed with the three-dimensional computer-aided design tools, and a hybrid model composed of cuboids and a point-cloud is generated automatically according to the virtual model of the object...
May 17, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29769379/activation-of-bacterial-histidine-kinases-insights-into-the-kinetics-of-the-cis-autophosphorylation-mechanism
#14
Gaurav D Sankhe, Narendra M Dixit, Deepak K Saini
Two-component signaling systems (TCSs) are central to bacterial adaptation. However, the mechanisms underlying the reactions involving TCS proteins and their reaction rates are largely undetermined. Here, we employed a combined experimental and theoretical approach to elucidate the kinetics of autophosphorylation of three histidine kinases (HKs) of Mycobacterium tuberculosis , viz. , MtrB, PrrB, and PhoR, all known to play a role in regulating its virulence. Using wild-type and mutant proteins, we performed dimerization assays, thermophoretic-affinity measurements, and competition-based phosphorylation assays to establish that for HK, MtrB autophosphorylation occurs in cis , similar to what has been proposed for the PhoR and PrrB HKs...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29768895/response-surface-optimization-on-adsorption-of-methyl-blue-onto-magnetic-1-x-nife%C3%A2-o%C3%A2-x-sio%C3%A2-nanocomposites
#15
Dawei He, Jian Chen, Yimin Lu, Rongzhu Lu, Ruijiang Liu
Methyl blue (MB) was adsorbed from aqueous solution by magnetic (1 - x)NiFe2O4/xSiO2 (x = 0-0.2) nanocomposites prepared via the facile solution combustion process. The effects of pH of MB solutions, silica content in nanocomposites and the calcination temperature for nanocomposites on the adsorption capacity of MB onto nanocomposites were investigated. Response surface methodology (RSM) based on three-level three-factorial Box-behnken design (BBD) was employed to optimize the adsorption technology of MB onto magnetic (1 - x)NiFe2O4/xSiO2 (x = 0-0...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29768005/a-versatile-aunp-synthetic-platform-for-decoupled-control-of-size-and-surface-composition
#16
Ye Yang, Luis Antonio Serrano González, Stefan Guldin
While a plethora of protocols exist for the synthesis of sub-10nm gold nanopar- ticles (AuNPs), the independent control over size and surface composition remains restricted. This poses a particular challenge for systematic studies of AuNP structure- function relationships and optimization of crucial design parameters. To this end, we report on a modular 2-step approach based on the synthesis of AuNPs in oleylamine (OAm) followed by the subsequent functionalization with thiol ligands and mixtures thereof. The synthesis of OAm-capped AuNPs enables fine tuning of the core size in the range of 2-7nm by varying the reaction temperature...
May 16, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29766598/dying-at-home-in-rural-residential-aged-care-a-mixed-methods-study-in-the-snowy-monaro-region-australia
#17
Suzanne Rainsford, Christine B Phillips, Nicholas J Glasgow, Roderick D MacLeod, Robert B Wiles
Residential aged care (RAC) is a significant provider of end-of-life care for people aged 65 years and older. Rural residents perceive themselves as different to their urban counterparts. Most studies describing place of death (PoD) in RAC are quantitative and reflect an urban voice. Using a mixed-methods design, this paper examines the PoD of 80 RAC residents (15 short-stay residents who died in RAC during respite or during an attempted step-down transition from hospital to home, and 65 permanent residents), within the rural Snowy Monaro region, Australia, who died between 1 February 2015 and 31 May 2016...
May 16, 2018: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29765657/facile-fabrication-of-microfluidic-surface-enhanced-raman-scattering-devices-via-lift-up-lithography
#18
Yuanzi Wu, Ye Jiang, Xiaoshan Zheng, Shasha Jia, Zhi Zhu, Bin Ren, Hongwei Ma
We describe a facile and low-cost approach for a flexibly integrated surface-enhanced Raman scattering (SERS) substrate in microfluidic chips. Briefly, a SERS substrate was fabricated by the electrostatic assembling of gold nanoparticles, and shaped into designed patterns by subsequent lift-up soft lithography. The SERS micro-pattern could be further integrated within microfluidic channels conveniently. The resulting microfluidic SERS chip allowed ultrasensitive in situ SERS monitoring from the transparent glass window...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29764294/impact-of-muslim-opinion-leaders-training-of-healthcare-providers-on-the-uptake-of-mnch-services-in-northern-nigeria
#19
Judith-Ann Walker, Yahaya Hashim, Nelson Oranye
Expanding access to maternal, newborn and child health (MNCH) services in traditional societies is a public health challenge, often complicated by cultural and religious beliefs about what is permitted or not permitted within a faith group. This is particularly true in the Muslim majority North of Nigeria, where deep suspicions of Western public health programmes, coupled with failing and underfunded health system, have led to the emergence of a new generation of Muslim Opinion Leaders (MOLs) with counter-narratives against family planning, immunisation and nutrition programmes...
May 15, 2018: Global Public Health
https://www.readbyqxmd.com/read/29762315/effectiveness-of-psychosocial-interventions-on-the-psychological-health-and-emotional-well-being-of-family-carers-of-people-with-dementia-following-residential-care-placement-a-systematic-review
#20
Deborah Brooks, Elaine Fielding, Elizabeth Beattie, Helen Edwards, Sonia Hines
OBJECTIVE: To identify, appraise and synthesize existing evidence regarding the effectiveness of psychosocial interventions on the psychological health and emotional well-being of family carers of people with dementia who have moved into residential care. INTRODUCTION: Many carers experience stress, guilt, grief and depression following placement of a relative with dementia into residential care. Psychosocial interventions to support family carers may help to improve psychological health and emotional well-being; however, evidence for such interventions delivered to family carers following placement has yet to be appraised and synthesized...
May 2018: JBI Database of Systematic Reviews and Implementation Reports
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