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https://www.readbyqxmd.com/read/29353432/post-translational-modifications-in-tumor-biomarkers-the-next-challenge-for-aptamers
#1
Ana Díaz-Fernández, Rebeca Miranda-Castro, Noemí de-Los-Santos-Álvarez, María Jesús Lobo-Castañón
Advances in proteomics have fueled the search for novel cancer biomarkers with higher selectivity. Differential expression of low abundant proteins has been the usual way of finding those biomarkers. The existence of a selective receptor for each biomarker is compulsory for their use in diagnostic/prognostic assays. Antibodies are the receptors of choice in most cases although aptamers are becoming familiar because of their facile and reproducible synthesis, chemical stability as well as comparable affinity and selectivity...
January 20, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29353402/factors-affecting-the-referral-rate-of-the-hoarding-disorder-at-primary-mental-health-care-in-quebec
#2
Yuliya Bodryzlova, Kieron O'Connor
Hoarding disorder (HD) places an important burden on people with HD, on their family members and society. In this paper we evaluate help-seeking in HD at primary mental health, measured in referral rate, together with its individual, environmental and structural correlates. We conducted an aggregate study by combining existing official data with our own survey data at the catchment area level. We found a mean annual referral rate of 1.58 (SD = 1.79) cases of HD in primary mental health facilities per 10,000 of adult population...
January 20, 2018: Community Mental Health Journal
https://www.readbyqxmd.com/read/29353369/mental-health-professionals-attitudes-towards-mental-illness-professional-and-cultural-factors-in-the-inter-nos-study
#3
Francisco Del Olmo-Romero, María González-Blanco, Salvador Sarró, Jaime Grácio, Manuel Martín-Carrasco, Ana C Martinez-Cabezón, Giampaolo Perna, Edith Pomarol-Clotet, Pedro Varandas, Javier Ballesteros-Rodríguez, Carlos Rebolleda-Gil, Giovanna Vanni, Eduardo González-Fraile
BACKGROUND: Research shows that personnel working in mental health facilities may share some of the societal prejudices towards mental illness. This might result in stigmatizing behaviours towards people suffering from mental disorders, undermining the quality of their care. AIMS: To describe and compare attitudes towards mental illness across a sample of professionals working in a wide range of mental health facilities in Spain, Portugal and Italy. METHOD: We administered a survey to personnel including two questionnaires related to stigmatizing attitudes: The Community Attitudes toward the Mentally Ill (CAMI) and the Attribution Questionnaire (AQ-27)...
January 20, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29353246/a-concept-mapping-approach-to-identifying-the-barriers-to-implementing-an-evidence-based-sports-injury-prevention-programme
#4
Alex Donaldson, Aisling Callaghan, Mario Bizzini, Andrew Jowett, Patrick Keyzer, Matthew Nicholson
BACKGROUND AND AIM: Understanding the barriers to programme use is important to facilitate implementation of injury prevention programmes in real-word settings. This study investigated the barriers to coaches of adolescent female soccer teams, in Victoria, Australia, implementing the evidence-based FIFA 11+ injury prevention programme. METHODS: Concept mapping with data collected from 19 soccer coaches and administrators. RESULTS: Brainstorming generated 65 statements as barriers to 11+ implementation...
January 20, 2018: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29353128/adoption-penetration-and-effectiveness-of-a-secondary-risk-screener-for-intimate-partner-violence-evidence-to-inform-screening-practices-in-integrated-care-settings
#5
Katherine M Iverson, Anneliese E Sorrentino, Scarlett L Bellamy, Alessandra R Grillo, Terri N Haywood, Elina Medvedeva, Christopher B Roberts, Melissa E Dichter
OBJECTIVE: Veterans Health Administration (VHA) has implemented screening for past-year intimate partner violence (IPV) in some healthcare facilities along with secondary screening of risk for severe violence among those screening positive in order to facilitate follow-up care for high-risk patients. We evaluated the adoption, penetration, and effectiveness of secondary screening as a tool to facilitate timely follow-up services. METHODS: Retrospective review of medical records (screening and healthcare use) of 774 women screening positive for past-year IPV (IPV+) at 11 facilities nationwide from April 2014-April 2016...
January 10, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29353114/toxic-hazards-of-ammonia-release-and-population-vulnerability-assessment-using-geographical-information-system
#6
N S Anjana, A Amarnath, M V Harindranathan Nair
Today, chemical industries manufacture, store and transport evermore hazardous substances and hence the risk of accidental releases of these chemicals can become more and more catastrophic in the context of increasing population and their requirements. The damage potential is proportional to the population characteristics of the location as well as various meteorological factors and geographical features. For the risk assessment of ammonia toxicity, the storage facility at Eloor industrial area is taken as a sample...
January 15, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29352973/the-senegal-urban-reproductive-health-initiative-a-longitudinal-program-impact-evaluation
#7
Aimee Benson, Lisa Calhoun, Meghan Corroon, Abdou Gueye, David Guilkey, Essete Kebede, Peter Lance, Rick O'Hara, Ilene S Speizer, John Stewart, Jennifer Winston
OBJECTIVES: This paper presents the impact of key components of the Senegal Urban Reproductive Health Initiative, including radio, television, community-based activities, Muslim religious-leader engagement and service quality improvement on modern contraceptive use by all women and the sub-sample of poor women. STUDY DESIGN: This study uses baseline (2011) and endline (2015) longitudinal data from a representative sample of urban women first surveyed in 2011 to examine the impact of the Initiative's demand- and supply-side activities on modern contraceptive use...
January 15, 2018: Contraception
https://www.readbyqxmd.com/read/29352940/pegylated-chitosan-nanoparticles-with-embedded-bismuth-sulfide-for-dual-wavelength-fluorescent-imaging-and-photothermal-therapy
#8
Ke Wang, Jialang Zhuang, Yubing Liu, Maosheng Xu, Jingyuan Zhuang, Zuanguang Chen, Yen Wei, Yuanqing Zhang
It is of great significance to construct multifunctional nanosystems for simultaneous imaging and therapy of cancer cells. Herein, PEGylated chitosan nanoparticles with embedded bismuth sulfide were facilely fabricated via reverse-microemulsion method for fluorescent imaging and photothermal therapy of HepG2 cells. The obtained BSA-Bi2S3-CG-PEG nanospheres revealed dual-wavelength fluorescence, which were spectrally isolated from the bioautofluorescence. Moreover, they demonstrated remarkable photothermal conversion efficiency and stability...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352915/silver-i-dithiocarbamate-on-modified-magnetic-cellulose-synthesis-density-functional-theory-study-and-application
#9
Samaneh Sabaqian, Firouzeh Nemati, Hossein Taherpour Nahzomi, Majid M Heravi
A magnetically retrievable catalytic system involving Ag(I) dithiocarbamate supported on functionalized cellulose was prepared. The structure of this hybrid nano-composite was characterized by various techniques. In addition, to describe the metal-ligand interactions present in the nano-composite, covalent and electrostatic interactions, density functional theory model and quantum theory of atoms in molecule method were employed. The resultant nano-composite exhibits remarkable catalytic efficacy in the synthesis of 2-amino-6-(2-oxo-2H-chromen-3-yl)-4-phenylnicotinonitriles from the reaction of 3-acetylcoumarin, aromatic aldehydes, and malononitrile...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352891/efficient-gene-delivery-by-oligochitosan-conjugated-serum-albumin-facile-synthesis-polyplex-stability-and-transfection
#10
Monika Kumari, Chi-Hsien Liu, Wei-Chi Wu
Chitosan and its derivatives have shown to be potential gene carriers with biocompatiblility and safety. However, their practical delivery is far from being ideal because of the low transfection efficiency. The present work describes the potential of a natural protein, bovine serum albumin (BSA), conjugated with a natural oligosaccharide, oligochitosan (OC), as a considerable promising approach for a safe and efficient non-viral gene delivery vector. The FTIR spectra proved the effective conjugation of BSA with OC through covalent bond...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352824/evaluating-the-effect-of-a-clostridium-difficile-infection-prevention-initiative-in-veterans-health-administration-long-term-care-facilities
#11
Maninder B Singh, Martin E Evans, Loretta A Simbartl, Stephen M Kralovic, Gary A Roselle
We evaluated rates of clinically confirmed long-term-care facility-onset Clostridium difficile infections from April 2014 through December 2016 in 132 Veterans Affairs facilities after the implementation of a prevention initiative. The quarterly pooled rate decreased 36.1% from the baseline (P<.0009 for trend) by the end of the analysis period. Infect Control Hosp Epidemiol 2018;1-3.
January 21, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29352754/providing-ethical-healthcare-in-resource-poor-environments
#12
Kenneth V Iserson
The ethics of providing health care in resource-poor environments is a complex topic. It implies two related questions: What can we do with the resources on hand? Of all the things we can do, which ones should we do? "Resource-poor" (i.e., resource-challenged, resource-constrained) environments are situations in which clinicians, organizations, or healthcare systems have the knowledge and skills, but not the means, to carry out highly effective and beneficial interventions. Determinants of a population's health often rely less on disease and injury management than on recognizing and meeting their basic needs...
January 19, 2018: HEC Forum: An Interdisciplinary Journal on Hospitals' Ethical and Legal Issues
https://www.readbyqxmd.com/read/29352706/environmental-conditions-in-health-care-facilities-in-low-and-middle-income-countries-coverage-and-inequalities
#13
Ryan Cronk, Jamie Bartram
Safe environmental conditions and the availability of standard precaution items are important to prevent and treat infection in health care facilities (HCFs) and to achieve Sustainable Development Goal (SDG) targets for health and water, sanitation, and hygiene. Baseline coverage estimates for HCFs have yet to be formed for the SDGs; and there is little evidence describing inequalities in coverage. To address this, we produced the first coverage estimates of environmental conditions and standard precaution items in HCFs in low- and middle-income countries (LMICs); and explored factors associated with low coverage...
January 11, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29352683/discharge-to-inpatient-rehab-does-not-result-in-improved-functional-outcomes-following-primary-total-knee-arthroplasty
#14
Douglas E Padgett, Alexander B Christ, Amethia D Joseph, You-Yu Lee, Stephen B Haas, Stephen Lyman
BACKGROUND: Monitored rehabilitation has long been considered an essential part of the recovery process in total knee arthroplasty (TKA). However, the optimal setting for rehabilitation remains uncertain. We sought to determine whether inpatient rehabilitation settings result in improved functional and patient-reported outcomes after primary TKA. METHODS: All patients undergoing primary TKA from May 2007 to February 2011 were identified from our institutional total joint registry...
December 28, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29352678/e-bike-related-trauma-in-children-and-adults
#15
Itai Gross, Daniel J Weiss, Elior Eliasi, Miklosh Bala, Saar Hashavya
BACKGROUND: Electric bike (e-bike) usage is growing worldwide, and so is the e-bike-related injury rate. OBJECTIVE: This study was undertaken to characterize e-bike-related injuries. METHODS: Data of all e-bike-related injuries presenting to our level I trauma center between 2014 and 2016 were collected and analyzed. Adult and pediatric (<18 years of age) e-bike-related injuries were then analyzed separately and compared. RESULTS: Forty-eight patients suffering from e-bike-related injuries presented to our trauma center between January 1, 2014 and December 31, 2016...
January 15, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29352640/recent-advancements-in-bioremediation-of-dye-current-status-and-challenges
#16
REVIEW
Kumar Vikrant, Balendu Shekhar Giri, Nadeem Raza, Kangkan Roy, Ki-Hyun Kim, Birendra Nath Rai, Ram Sharan Singh
The rampant industrialization and unchecked growth of modern textile production facilities coupled with the lack of proper treatment facilities have proliferated the discharge of effluents enriched with toxic, baleful, and carcinogenic pollutants including dyes, heavy metals, volatile organic compounds, odorants, and other hazardous materials. Therefore, the development of cost-effective and efficient control measures against such pollution is imperative to safeguard ecosystems and natural resources. In this regard, recent advances in biotechnology and microbiology have propelled bioremediation as a prospective alternative to traditional treatment methods...
January 8, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29352581/facile-gas-chromatography-tandem-mass-spectrometry-stable-isotope-dilution-method-for-the-quantification-of-sesquiterpenes-in-grape
#17
Nina Duhamel, Davide Slaghenaufi, Lisa I Pilkington, Mandy Herbst-Johnstone, Roberto Larcher, David Barker, Bruno Fedrizzi
Sesquiterpenes are a widespread class of compounds of increasing interest found in grapes and wines, amongst many other natural sources. Due to a lack of standards and the complexity of the mass spectra fragmentation, accurate quantification of these low concentration compounds had not previously been accomplished. The current paper presents a new method for the concurrent quantification of several sesquiterpenes. The multivariate method optimisation is presented. Synthesised isotopic standards were utilised in conjunction with solid phase microextraction (SPME) and gas chromatography-tandem mass spectrometry (GC-MS/MS) to perform a standard isotope dilution assay (SIDA)...
January 5, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29352418/effect-of-patient-experience-on-bypassing-a-primary-care-gatekeeper-a-multicenter-prospective-cohort-study-in-japan
#18
Takuya Aoki, Yosuke Yamamoto, Tatsuyoshi Ikenoue, Makoto Kaneko, Morito Kise, Yasuki Fujinuma, Shunichi Fukuhara
BACKGROUND: To discuss how best to implement the gatekeeping functionality of primary care; identifying the factors that cause patients to bypass their primary care gatekeepers when seeking care should be beneficial. OBJECTIVE: To examine the association between patient experience with their primary care physicians and bypassing them to directly obtain care from higher-level healthcare facilities. DESIGN AND METHODS: This prospective cohort study was conducted in 13 primary care clinics in Japan...
January 19, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29352278/factors-associated-with-cervical-precancerous-lesions-among-women-screened-for-cervical-cancer-in-addis-ababa-ethiopia-a-case-control-study
#19
Hirut Teame, Adamu Addissie, Wondimu Ayele, Selamawit Hirpa, Alem Gebremariam, Gdiom Gebreheat, Ahmedin Jemal
BACKGROUND: Cervical cancer is the second most prevalent cancer among women in the developing countries including Ethiopia. Precancerous lesions can be developed and risk to the development of cervical cancer over time. Early identification of the precancerous lesion and its risk factor is paramount in preventing cervical cancer. However, the determinants of cervical precancerous lesions are not well documented in Ethiopia. Therefore, this study is conducted to determine factors associated with cervical precancerous lesion among women screened for cervical cancer...
2018: PloS One
https://www.readbyqxmd.com/read/29352260/effect-of-in-vitro-storage-duration-on-measured-mechanical-properties-of-brain-tissue
#20
Wei Zhang, Li-Fu Liu, Yue-Jiao Xiong, Yi-Fan Liu, Sheng-Bo Yu, Cheng-Wei Wu, Weihong Guo
Accurate characterization of the mechanical properties of brain tissue is essential for understanding the mechanisms of traumatic brain injuries and developing protective gears or facilities. However, how storage conditions might affect the mechanical properties of brain tissue remains unclear. The objective of this study is to investigate the effect of in vitro storage duration on the mechanical performance of brain tissue since measurements are usually carried out in vitro. Differential Scanning Calorimetry (DSC) measurements and uniaxial compression mechanical experiments are carried out...
January 19, 2018: Scientific Reports
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